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Journal articles on the topic 'PGSHT'

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Published: 4 June 2021
Last updated: 10 February 2022

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1

Doyle, Peter R., Mark McGee, Aidan P. Moloney, Alan K. Kelly, and Edward G. O’Riordan. "Effect of Post-Grazing Sward Height, Sire Genotype and Indoor Finishing Diet on Steer Intake, Growth and Production in Grass-Based Suckler Weanling-to-Beef Systems." Animals 11, no. 9 (September 7, 2021): 2623. http://dx.doi.org/10.3390/ani11092623.

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This study evaluated the effects of post-grazing sward height (PGSH, 4 or 6 cm) on herbage production, its nutritive value, dry matter (DM) intake, grazing behaviour and growth of early- (EM) and late-maturing (LM) breed suckler steers (n = 72), and the subsequent effect of indoor finishing diet (grass silage + 3.8 kg concentrate DM/head daily (SC), or grass silage only (SO)) on performance and carcass traits. Animals rotationally grazed pasture for 196 days, followed by indoor finishing for 119 days. At pasture, daily live-weight gain (LWG) was 0.10 kg greater for PGSH-6 than PGSH-4, resulting in a tendency for carcass weight to be 11 kg heavier. Although EM had a 0.10 kg greater daily LWG at pasture than LM, carcass weight did not differ between the genotypes. There was a genotype × PGSH interaction for carcass fat score, whereby there was no difference between EM-4 (8.83, 15-point scale) and EM-6 (8.17), but LM-6 (7.28) was greater than LM-4 (6.33). Although concentrate supplementation during indoor finishing increased carcass weight (+37 kg) and fat score (1.75 units), the majority of steers (83% of EM and 78% of LM) achieved a commercially-acceptable carcass fat score (6.78) at slaughter in the grass-forage-only system.
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2

Fedulova, Natalia, Françoise Raffalli-Mathieu, and Bengt Mannervik. "Porcine glutathione transferase Alpha 2-2 is a human GST A3-3 analogue that catalyses steroid double-bond isomerization." Biochemical Journal 431, no. 1 (September 14, 2010): 159–67. http://dx.doi.org/10.1042/bj20100839.

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A primary role of GSTs (glutathione transferases) is detoxication of electrophilic compounds. In addition to this protective function, hGST (human GST) A3-3, a member of the Alpha class of soluble GSTs, has prominent steroid double-bond isomerase activity. The isomerase reaction is an obligatory step in the biosynthesis of steroid hormones, indicating a special role of hGST A3-3 in steroidogenic tissues. An analogous GST with high steroid isomerase activity has so far not been found in any other biological species. In the present study, we characterized a Sus scrofa (pig) enzyme, pGST A2-2, displaying high steroid isomerase activity. High levels of pGST A2-2 expression were found in ovary, testis and liver. In its functional properties, other than steroid isomerization, pGST A2-2 was most similar to hGST A3-3. The properties of the novel porcine enzyme lend support to the notion that particular GSTs play an important role in steroidogenesis.
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3

Fricker, M., and A. Helbling. "Nichtsteroidale Antirheumatika(NSAR)- oder Prostaglandin-Synthesehemmer (PGSH)-Intoleranz: Beurteilung und Management von Überempfindlichkeitsreaktionen." Allergologie 32, no. 09 (September 1, 2009): 350–57. http://dx.doi.org/10.5414/alp32350.

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4

Buchta, I., E. Kula, and M. Kresťanpolová. "Occurrence variations and spatial distribution patterns of Eriophyes tiliae (Pgst.) (Acari, Eriophyidae) subspecies in the urban environment." Journal of Forest Science 52, No. 12 (January 9, 2012): 547–55. http://dx.doi.org/10.17221/4535-jfs.

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The occurrence of Eriophyes tiliae (Pgst.) subspecies was observed in lime trees in the urban area of Brno. Mites presence was assessed in relation to the lime species, its age and health conditions. Analysis of the occurrence of liosoma, tiliae and nervalis subspecies was carried out on leaves of 3,245 lime trees from the viewpoint of the host preference and spatial distribution of attack in the area of the city and potential effects of air pollution. Subspecies liosoma and tiliae occurred in 13% of lime trees, the subspecies of nervalis was found only in 4 limes. Eudominant subspecies of E. tiliae preferred mature trees and young trees reaching height of mature trees in good health conditions. The distribution of Eriophyes tiliae on lime trees in the area ofBrno depended on the distribution of suitable host trees and was not affected by air pollution.
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5

Dennill, G. B. "An ecological basis for timing control measures against the grape vine bud mite Eriophyes vitis Pgst." Crop Protection 5, no. 1 (February 1986): 12–14. http://dx.doi.org/10.1016/0261-2194(86)90033-5.

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6

Dirr, Heini, Peter Reinemer, and Robert Huber. "Refined Crystal Structure of Porcine Class Pi Glutathione S-Transferase (pGST P1-1) at 2·1 Å Resolution." Journal of Molecular Biology 243, no. 1 (October 1994): 72–92. http://dx.doi.org/10.1006/jmbi.1994.1631.

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7

Donadei, Marta. "El papel de la participación en la transición socio-ecológica de la ciudad." Retos 9, no. 17 (March 28, 2019): 55–70. http://dx.doi.org/10.17163/ret.n17.2019.04.

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Pese a la creciente sensibilización a los efectos del cambio climático, sus cada vez más acusadas consecuencias demuestran el peligro que supone el seguir con el imperativo unilateral del crecimiento económico, caracterizado por una ‘intoxicación consumista’ que nos ha llevado a esta situación de carestía crónica global de recursos (Fernández Durán & González Reyes, 2014; Hessel & Morin, 2012). En este contexto, “el nuevo enfoque no puede reducirse a mero arreglo cosmético de un paradigma en crisis” (Max Neef, Elizalde, & Hopenhayn, 1994, p. 37), sino que requiere también un cambio de paradigma para avanzar hacia la sostenibilidad ambiental y la equidad social. Para ello se quiere incidir en el hecho de que la involucración activa de la población resulta elemento clave para activar un cambio en la forma que la sociedad occidental tiene de entender la naturaleza y para construir alternativas reales al actual modelo de ocupación del territorio, que estén basadas en el paradigma ecológico. Así, el planteamiento de este artículo encuentra sus bases teóricas en la Producción y Gestión Social del Hábitat (en adelante PGSH), entendiendo por Trasformación Social del Hábitat el conjunto de procesos tendientes a la transformación del hábitat existente en los cuales la iniciativa ciudadana tiene un papel activo en la toma de decisiones.
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8

Santiago, J. L., K. Mandl, R. Hack, and F. Regner. "QUANTITATIVE TRAIT LOCI ANALYSIS OF SENSITIVITY TO ERINOSE (ERIOPHYES VITIS PGST.) AND HAIR DENSITY, BASED ON A GENETIC MAP OF 'WELSCHRIESLING' × 'SIRIUS'." Acta Horticulturae, no. 827 (May 2009): 341–46. http://dx.doi.org/10.17660/actahortic.2009.827.58.

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9

Kononenko, Svetlana Vladimirovna, and Evgenia Georgievna Yurchenko. "BIOECOLOGICAL CHARACTERISTIC FEATURES AND HARMFULNESS OF GRAPE FELT MITE (COLOMERUS VITIS PGST.) AND LEAF PHILLOXER (DAKTULOSPHAIRA VITIFOLIAE (GALLICOLAE) FITCH) IN THE WESTERN CISCAUCASIA VINEYARDS (RUSSIA)." Fruit growing and viticulture of South Russia 4, no. 70 (July 20, 2021): 222–39. http://dx.doi.org/10.30679/2219-5335-2021-4-70-222-239.

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10

Ariasa, Gede Wiga Anggara, Luh Putu Sendratari, and I. Gusti Made Arya Sutha Wirawan. "PEMANFAATAN MEDIA SOSIAL PADA SEKAA TRUNA TRUNI PARA GOTRA SENTANA DALEM TARUKAN (STT PGSDT) SEBAGAI MODEL INTERAKSI BERBASIS IT DI BANJAR DINAS MELAKA BULELENG, BALI." Jurnal Pendidikan Sosiologi Undiksha 2, no. 2 (September 23, 2020): 129. http://dx.doi.org/10.23887/jpsu.v2i2.28057.

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AbstrakMedia sosial merupakan media online dengan para penggunanya mudah berinteraksi dalam dunia virtual (dunia maya). Zaman semakin berkembang dengan terciptanya media sosial, yang memudahkan masyarakat berkomunikasi tanpa terhalang jarak dan waktu. Media sosial saat menjadi kebutuhan wajib bagi masyarakat, karena tanpa adanya media sosial, masyarakat tidak bisa mengetahui berita dan informasi yang terbaru. Media sosial memiliki beberapa fungsi yaitu digunakan dalam bisnis, hiburan dan termasuk juga dalam organisasi kepemudaan. Organisasi kepemudaan merupakan lembaga yang menghimpun segenap potensi anak muda yang akan mendidik mereka dengan tujuan menjadi berguna dalam kehidupan bermasyarakat. Organisasi kepemudaan berdiri bersama dengan visi, misi dan beberapa aturan yang mengikat para anggotanya. Organisasi kepemudaan menggunakan media sosial sebagai alat bantu komunikasi dengan tujuan mempermudah komunikasi yang dilakukan oleh para anggota organisasi. Para anggota yang mayoritas sudah mempunyai sosial media akan dengan cepatnya mendapatkan informasi terkait dengan kegiatan di organisasi.Kata Kunci : Media Sosial, Organisasi Kepemudaan, Interaksi Sosial
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11

Jia, Lianghui, Hairong Cheng, Hengwei Wang, Huairong Luo, and Hua Yan. "From shake flasks to bioreactors: survival of E. coli cells harboring pGST–hPTH through auto-induction by controlling initial content of yeast extract." Applied Microbiology and Biotechnology 90, no. 4 (March 10, 2011): 1419–28. http://dx.doi.org/10.1007/s00253-011-3179-5.

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12

Guillou Landreat, Morgane, Isabelle Chereau Boudet, Bastien Perrot, Lucia Romo, Irene Codina, David Magalon, Melina Fatseas, et al. "Problem and non-problem gamblers: a cross-sectional clustering study by gambling characteristics." BMJ Open 10, no. 2 (February 2020): e030424. http://dx.doi.org/10.1136/bmjopen-2019-030424.

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ObjectivesGambling characteristics are factors that could influence problem gambling development. The aim of this study was to identify a typology of gamblers to frame risky behaviour based on gambling characteristics (age of initiation/of problem gambling, type of gambling: pure chance/chance with pseudoskills/chance with elements of skill, gambling online/offline, amount wagered monthly) and to investigate clinical factors associated with these different profiles in a large representative sample of gamblers.Design and settingThe study is a cross-sectional analysis to the baseline data of the french JEU cohort study (study protocol : Challet-Boujuet al, 2014). Recruitment (April 2009 to September 2011) involved clinicians and researchers from seven institutions that offer care for or conduct research on problem gamblers (PG). Participants were recruited in gambling places, and in care centres. Only participants who reported gambling in the previous year between 18 and 65 years old were included.Participants gave their written informed consent, it was approved by the French Research Ethics Committee.ParticipantsThe participants were 628 gamblers : 256 non-problem gamblers (NPG), 169 problem gamblers without treatment (PGWT) and 203 problem gamblers seeking treatment (PGST).ResultsSix clustering models were tested, the one with three clusters displayed a lower classification error rate (7.92%) and was better suited to clinical interpretation : ‘Early Onset and Short Course’ (47.5%), ‘Early Onset and Long Course’ (35%) and ‘Late Onset and Short Course’ (17.5%). Gambling characteristics differed significantly between the three clusters.ConclusionsWe defined clusters through the analysis of gambling variables, easy to identify, by psychiatrists or by physicians in primary care. Simple screening concerning these gambling characteristics could be constructed to prevent and to help PG identification. It is important to consider gambling characteristics : policy measures targeting gambling characteristics may reduce the risk of PG or minimise harm from gambling.Trial registration numberNCT01207674(ClinicalTrials.gov); Results.
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13

Li, Ming, Ting Yang, Michelle Bui, Stephanie Gamez, Tyler Wise, Nikolay P. Kandul, Junru Liu, et al. "Suppressing mosquito populations with precision guided sterile males." Nature Communications 12, no. 1 (September 10, 2021). http://dx.doi.org/10.1038/s41467-021-25421-w.

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AbstractThe mosquito Aedes aegypti is the principal vector for arboviruses including dengue/yellow fever, chikungunya, and Zika virus, infecting hundreds of millions of people annually. Unfortunately, traditional control methodologies are insufficient, so innovative control methods are needed. To complement existing measures, here we develop a molecular genetic control system termed precision-guided sterile insect technique (pgSIT) in Aedes aegypti. PgSIT uses a simple CRISPR-based approach to generate flightless females and sterile males that are deployable at any life stage. Supported by mathematical models, we empirically demonstrate that released pgSIT males can compete, suppress, and even eliminate mosquito populations. This platform technology could be used in the field, and adapted to many vectors, for controlling wild populations to curtail disease in a safe, confinable, and reversible manner.
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14

Shippy, Daniel C., Justin J. Lemke, Aubrey Berry, Kathryn Nelson, Murray E. Hines, and Adel M. Talaat. "Superior Protection from Live-Attenuated Vaccines Directed against Johne's Disease." Clinical and Vaccine Immunology 24, no. 1 (November 2, 2016). http://dx.doi.org/10.1128/cvi.00478-16.

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ABSTRACT Mycobacterium avium subsp. paratuberculosis (M. paratuberculosis) is the etiological agent of Johne's disease in ruminants. Johne's disease is an important enteric infection causing large economic losses associated with infected herds. In an attempt to fight this infection, we created two novel live-attenuated vaccine candidates with mutations in sigH and lipN (pgsH and pgsN, respectively). Earlier reports in mice suggested these vaccines are promising candidates to fight Johne's disease in ruminants. In this study, we tested the performances of the two constructs as vaccine candidates using the goat model of Johne's disease. Both vaccines appeared to provide significant immunity to goats against challenge from wild-type M. paratuberculosis. The pgsH and pgsN constructs showed a significant reduction in histopathological lesions and tissue colonization compared to nonvaccinated goats and those vaccinated with an inactivated vaccine. Unlike the inactivated vaccine, the pgsN construct was able to eliminate fecal shedding from challenged animals, a feature that is highly desirable to control Johne's disease in infected herds. Furthermore, strong initial cell-mediated immune responses were elicited in goats vaccinated with pgsN that were not demonstrated in other vaccine groups. Overall, the results indicate the potential use of live-attenuated vaccines to control intracellular pathogens, including M. paratuberculosis, and warrant further testing in cattle, the main target for Johne's disease control programs.
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15

YANG, YULIN, LIANGDE LI, JINGCHI TANG, and XIAOLI RAO. "The PGST-DBSCAN Algorithm for Mining Clusters from Massive Spatial-temporal Data." DEStech Transactions on Computer Science and Engineering, aiea (October 31, 2017). http://dx.doi.org/10.12783/dtcse/aiea2017/14917.

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16

Guneidy, R. A., A. M. Gad, E. R. Zaki, F. M. Ibrahim, and A. Shokeer. "Antioxidant or pro-oxidant and glutathione transferase P1-1 inhibiting activities for Tamarindus indica seeds and their cytotoxic effect on MCF-7 cancer cell line." Journal of Genetic Engineering and Biotechnology 18, no. 1 (November 19, 2020). http://dx.doi.org/10.1186/s43141-020-00077-z.

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Abstract Background The multidrug resistance (MDR) of cancer cells is a major obstacle to cancer treatment. Glutathione S-transferase Pi (GSTP1-1) catalyzes the conjugation of glutathione with anticancer drugs and therefore reduces their efficacy. Phenolic compounds have the potential to inhibit GST P1-1 activity, which is a promising goal to overcome MDR and increase the efficacy of chemotherapy. Results Three fractions (dichloromethane, ethyl acetate, and n-butanol) were prepared from Tamarindus indica seeds to determine their phenolic and flavonoid properties as well as their antioxidant/pro-oxidant properties. The n-butanol fraction displayed the highest levels of phenol ( 378 ± 11.7 mg gallic acid equivalent/g DW) and flavonoids (83 ± 6.0 mg rutin equivalent/g DW). Inhibiting effects on purified GSTP1-1 activity in human erythrocytes (eGST), placenta (pGST), and hGSTP1-1 have been studied. The n-butanol fraction was the most effective in inhibiting eGST, hGSTP1-1, and pGST with IC50 values of 3.0 ± 0.7, 4.85 ± 0.35, and 6.6 ± 1.2 μg/ml, respectively. Cellular toxicity was investigated for the T. indica n-butanol fraction on various human cancerous cell lines. The only ones affected were MCF-7 cell lines (72%) and HePG2 (52%) indicated cytotoxicity. The value of IC50 is 68.5 μg/ml of T. indica n-butanol fraction was observed compared to 1.7 μg/ml tamoxifen in MCF-7 cell lines. The combination of treatment of T. indica extract with the medicinally approved drug tamoxifen had unexpected effects; complete elimination of the cytotoxic inhibition effect of tamoxifen and the plant extract was observed. Conclusions However T. indica extract has a cytotoxic effect on the MCF-7 cell line; in certain situations, plant products can have an opposite effect to the intended drug, which decreases the impact of the drug.
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17

Valdés, I., and E. Coy-Barrera. "Inhibition of PGSH-1 (COX-1) by flavonoids isolated from a neotropical Lauraceae: A docking study." Planta Medica 78, no. 11 (July 2012). http://dx.doi.org/10.1055/s-0032-1320532.

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18

Tiwari, Vishnu Shankar, and Arti Arya. "Horizontally scalable probabilistic generalized suffix tree (PGST) based route prediction using map data and GPS traces." Journal of Big Data 4, no. 1 (July 19, 2017). http://dx.doi.org/10.1186/s40537-017-0085-4.

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19

Friard, Jonas, Alain Corinus, Marc Cougnon, Michel Tauc, Didier F. Pisani, Christophe Duranton, and Isabelle Rubera. "LRRC8/VRAC channels exhibit a noncanonical permeability to glutathione, which modulates epithelial-to-mesenchymal transition (EMT)." Cell Death & Disease 10, no. 12 (December 2019). http://dx.doi.org/10.1038/s41419-019-2167-z.

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AbstractVolume-regulated anion channels (VRAC) are chloride channels activated in response to osmotic stress to regulate cellular volume and also participate in other cellular processes, including cell division and cell death. Recently, members of the LRRC8 family have been identified as the main contributors of VRAC conductance. LRRC8/VRAC is permeable to chloride ions but also exhibits significant permeability to various substrates that vary strongly in charge and size. In this study, we explored the intriguing ability of LRRC8/VRAC to transport glutathione (GSH), the major cellular reactive oxygen species (ROS) scavenger, and its involvement in epithelial-to-mesenchymal transition (EMT), a cellular process in which cellular oxidative status is a crucial step. First, in HEK293-WT cells, we showed that a hypotonic condition induced LRRC8/VRAC-dependent GSH conductance (PGSH/PCl of ~0.1) and a marked decrease in intracellular GSH content. GSH currents and GSH intracellular decrease were both inhibited by DCPIB, an inhibitor of LRRC8/VRAC, and were not observed in HEK293-LRRC8A KO cells. Then, we induced EMT by exposing renal proximal tubule epithelial cells to the pleiotropic growth factor TGFβ1, and we measured the contribution of LRRC8/VRAC in this process by measuring (i) EMT marker expression (assessed both at the gene and protein levels), (ii) cell morphology and (iii) the increase in migration ability. Interestingly, pharmacologic targeting of LRRC8/VRAC (DCPIB) or RNA interference-mediated inhibition (LRRC8A siRNA) attenuated the TGFβ1-induced EMT response by controlling GSH and ROS levels. Interestingly, TGFβ1 exposure triggered DCPIB-sensitive chloride conductance. These results suggest that LRRC8/VRAC, due to its native permeability to GSH and thus its ability to modulate ROS levels, plays a critical role in EMT and might contribute to other physiological and pathophysiological processes associated with oxidative stress.
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