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Dissertations / Theses on the topic 'Ph+ Acute Lymphoblastic Leukemia'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

LIPKIN, VASQUEZ MARINA. "Unveiling the heterogeneity within chilhood Ph+ acute lymphoblastic leukemia." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2011. http://hdl.handle.net/10281/20633.

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In the past two decades, childhood acute lymphoblastic leukemia (ALL) cure rate has reached over 80% due to treatment advances, but some resistant ALL subtypes, such as those that carry the Philadelphia (Ph+) chromosome, still don’t respond to therapy. The presence of BCR-ABL in ALL children is correlated to a very poor prognosis, nevertheless, several long-scale studies have shown that Ph+ ALL is heterogeneous in terms of clinical parameters and patients respond differently to the therapy, what suggests the presence of additional mechanisms of leukemogenesis. A set of international studies wi

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2

Paganin, Maddalena. ""High Risk" Acute Lymphoblastic Leukemia." Doctoral thesis, Università degli studi di Padova, 2009. http://hdl.handle.net/11577/3427207.

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Acute lymphoblastic leukemia (ALL) is a neoplasia characterized by an abnormal, clonal and self-maintaining proliferation of lymphoid cells. In this three year of phd I tried to add some information to understand the complex molecular mechanisms underlying this disease. I performed my studies in the laboratory of "Oncoematologia Pediatrica, Dipartimento di Pediatria dell'Università degli studi di Padova" and for three months in the laboratory of Prof. A. A. Ferrando, Columbia University, Irving Cancer Center, New York. The recombination, insertion and deletion of immunoglobulin (Ig) and T

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3

Kuchinskaya, Ekaterina. "Genetic studies of acute lymphoblastic leukemia /." Stockholm : Karolinska institutet, 2007. http://diss.kib.ki.se/2007/978-91-7357-337-5/.

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4

Lo, Tony Chung Tung. "Inactivation of SHIP1 in acute lymphoblastic leukemia." Diss., [La Jolla] : University of California, San Diego, 2009. http://wwwlib.umi.com/cr/ucsd/fullcit?p1465620.

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Thesis (M.S.)--University of California, San Diego, 2009.<br>Title from first page of PDF file (viewed July 22, 2009). Available via ProQuest Digital Dissertations. Includes bibliographical references (p. 63-69).

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5

Kanerva, Jukka. "Prognostic factors in childhood acute lymphoblastic leukemia (ALL)." Helsinki : University of Helsinki, 2002. http://ethesis.helsinki.fi/julkaisut/laa/kliin/vk/kanerva/.

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6

Oliveira, Tiago M. "The importance of glycosylation in Acute Lymphoblastic Leukemia." Thesis, Griffith University, 2021. http://hdl.handle.net/10072/410463.

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Acute leukemias, such as acute lymphoblastic leukemia (ALL), are aggressive cancers characterized by the rapid proliferation of malignant hematopoietic cells. Throughout the last 60 years, childhood ALL’s long-term survival rates increased from less than 10% to more than 90%. Despite these improvements, certain subtypes remain hard to manage (e.g. mixed lineage leukemia, MLL-r), and even new therapies frequently fail. Therefore, identifying leukemia-cell restricted antigens in these ALL subtypes remains crucial in the quest to develop novel diagnostic tools and specific treatments. Traditional

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7

卓大治 and Tai-chi Cheuk. "Childhood acute lymphoblastic leukaemia with TEL-AML1 gene fusion." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2000. http://hub.hku.hk/bib/B31969690.

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8

Cheuk, Tai-chi. "Childhood acute lymphoblastic leukaemia with TEL-AML1 gene fusion." Hong Kong : University of Hong Kong, 2000. http://sunzi.lib.hku.hk/hkuto/record.jsp?B22264619.

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9

Akers, Stephen Matthew. "Modeling central nervous system involvement in acute lymphoblastic leukemia." Morgantown, W. Va. : [West Virginia University Libraries], 2010. http://hdl.handle.net/10450/11227.

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Thesis (Ph. D.)--West Virginia University, 2010.<br>Title from document title page. Document formatted into pages; contains x, 102 p. : ill. (some col.). Includes abstract. Includes bibliographical references.

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10

Thörn, Ingrid. "Minimal Residual Disease Assessment in Childhood Acute Lymphoblastic Leukemia." Doctoral thesis, Uppsala universitet, Institutionen för genetik och patologi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-101028.

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Traditionally, response to treatment in hematological malignancies is evaluated by light microscopy of bone marrow (BM) smears, but due to more effective therapies more sensitive methods are needed. Today, detection of minimal residual disease (MRD) using immunological and molecular techniques can be 100 times more sensitive than morphology. The main aim of this thesis was to compare and evaluate three currently available MRD methods in childhood acute lymphoblastic leukemia (ALL): (i) real-time quantitative PCR (RQ-PCR) of rearranged antigen receptor genes, (ii) multicolor flow cytometry (FCM

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11

Nordlund, Jessica. "Gene Expression and DNA Methylation in Acute Lymphoblastic Leukemia." Doctoral thesis, Uppsala universitet, Molekylär medicin, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-179680.

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Pediatric acute lymphoblastic leukemia (ALL) is the most common malignancy in children, which results from the malignant transformation of progenitor cells in the bone marrow into leukemic cells. The precise mechanisms for this transformation are not well defined, however recent studies suggest that aberrant regulation of gene expression or DNA methylation may play an important role. Hence, the aim of this thesis was to use novel methods to investigate genome-wide gene expression and DNA methylation patterns in a large collection of primary ALL cells from pediatric patients. With these studies

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12

Thörn, Ingrid. "Minimal Residual Disease Assessment in Childhood Acute Lymphoblastic Leukemia." Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-101028.

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13

Basnett, Jordan. "Characterisation of Resistance to Everolimus in Acute Lymphoblastic Leukemia." Thesis, The University of Sydney, 2016. http://hdl.handle.net/2123/16332.

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Acute Lymphoblastic Leukemia (ALL) is the most common childhood cancer. Disease relapse following treatment still occurs in a significant minority of children and the majority of adult patients. The inability to further intensify current treatments due to dose limiting toxicities of chemotherapeutic agents demands the development of new agents. One exciting new treatment, is the mTOR inhibitor everolimus. Preclinical studies using everolimus, while promising, revealed that resistance can emerge following prolonged treatment in vivo. This study uses ALL xenografts that have developed resistance

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14

McLellan, Gail. "The role of monoclonal antibodies in the diagnosis of acute leukaemia." Thesis, Cape Technikon, 1990. http://hdl.handle.net/20.500.11838/1498.

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Thesis (Master Diploma(Medical Technology) -- Cape Technikon, Cape Town, 1990<br>Eighty six patients with acute l.eukaemia were studied using morphol.ogical., cytochemical. and immunol.ogical. techniques. The acute l.eukaemias were subdivided using the French-American-British (FAB) cl.assification. The immunophenotyping studies were compared with the morphological classification to assess their contribution to the diagnosis. Acute non-lymphoblastic leukaemia (ANLL) was diagnosed on the basis of morphol.ogy and cytochemical. criteria. In addition this group of patients was studied with

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15

Oram, Sarah Helen. "Cis-regulation of LM02 in T-acute lymphoblastic leukaemia." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609663.

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16

Larery, Angela R. D. McGill Jerry C. "Hierarchical neuropsychological functioning among pediatric survivors of acute lymphoblastic leukemia." [Denton, Tex.] : University of North Texas, 2007. http://digital.library.unt.edu/permalink/meta-dc-3949.

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17

Van, Vlierberghe Pieter. "Moleciular-genetic insights in pediatric T-cell acute lymphoblastic leukemia." [S.l.] : Rotterdam : [The Author] ; Erasmus University [Host], 2008. http://hdl.handle.net/1765/12225.

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18

Lindqvist, Carl Mårten. "Genomic characterization of pediatric acute lymphoblastic leukemia by deep sequencing." Doctoral thesis, Uppsala universitet, Molekylär medicin, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-269760.

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Acute Lymphoblastic Leukemia (ALL) is the most common cancer in children, with close to 200 cases per year in the Nordic countries. Despite recent advances in modern chemotherapies, 20% of the ALL patients experience a relapse. ALL has traditionally been stratified into subtypes with different risk classification and therapy using large genomic aberrations such as translocations and aneuploidies. In recent years technological advances have enabled the detection of smaller genetic variants, such as point mutations and small insertions/deletions. This thesis focuses on the detection of these sma

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19

Borssén, Magnus. "DNA methylation as a prognostic marker i acute lymphoblastic leukemia." Doctoral thesis, Umeå universitet, Patologi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-127225.

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Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy. Most ALL cases originate from immature B-cells (BCP-ALL) and are characterized by reoccurring structural genetic aberrations. These aberrations hold information of the pathogenesis of ALL and are used for risk stratification in treatment. Despite increased knowledge of genetic aberrations in pediatric T-cell ALL (T-ALL), no reliable molecular genetic markers exist for identifying patients with higher risk of relapse. The lack of molecular prognostic markers is also evident in patients with relapsed ALL. During the last

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20

Rocchetti, Francesca. "Study of calcineurin pro-oncogenic role in acute lymphoblastic leukemia." Sorbonne Paris Cité, 2015. http://www.theses.fr/2015USPCC166.

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Malgré les avancés thérapeutiques, le pronostic des leucémies aiguës lymphoblastiques (LAL) reste mauvais. Notre laboratoire a montré que la calcineurine (Cn) est requise pour le maintien à long terme des LAL-T. Sa délétion est associée à la dérégulation de l'expression de plusieurs gènes, dont TRNP1 et NFIB, qui sont nouveaux dans le contexte des LAL-T. Nous avons montré que la suppression de leur expression a un effet délétère sur les cellules leucémiques de LAL-T in vitro et in vivo. Cn est aussi activée dans les LAL-B BCR-ABL+. Des travaux publiés ont proposé que son inhibition par la cycl

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21

Larery, Angela R. D. "Hierarchical neuropsychological functioning in pediatric survivors of acute lymphoblastic leukemia." Thesis, University of North Texas, 2007. https://digital.library.unt.edu/ark:/67531/metadc3949/.

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Acute lymphocytic leukemia (ALL) is one of the most common types of pediatric cancers. Improvements in treatment within the last 20 years have resulted in reduced mortality and a greater focus upon quality of life. Several researchers have documented neuropsychological impairments in children following treatment for ALL; however, there have not been any comparative studies documenting differences in neuropsychological functioning based upon treatment modality despite the documented effects of radiation therapy and combined radiation/chemotherapy upon the developing brain. In addition, past stu

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22

Withycombe, Janice Squires. "Early Weight Gain and Obesity in Childhood Acute Lymphoblastic Leukemia." Diss., The University of Arizona, 2012. http://hdl.handle.net/10150/223340.

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Obesity is a recognized problem for children treated for acute lymphoblastic leukemia (ALL) and is present in roughly one fourth of children by the end of therapy. Obesity may lead to immediate health threats, such as an increased risk for cancer relapse, or may cause future heath issues such as diabetes, metabolic syndrome, hypertension, additional cancers, depression or cardiovascular disease. The purpose of this study was to determine if weight gain during two individual cycles of therapy (Induction or Delayed Intensification Cycle 1) were predictive of obesity (defined as body mass index ≥

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23

Gottardo, Nicholas G. "Oncogenes and prognosis in childhood T-cell acute lymphoblastic leukaemia." University of Western Australia. School of Paediatrics and Child Health, 2008. http://theses.library.uwa.edu.au/adt-WU2009.0039.

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[Truncated abstract] The treatment of childhood acute lymphoblastic leukaemia (ALL) is one of the great success stories of paediatric oncology, transforming a universally fatal disease into one where 75 to 90% of children are now cured. Although in the past survival for children with T-cell ALL (T-ALL) lagged behind that of children with pre-B ALL, the use of contemporary intensified treatment strategies has significantly diminished this difference, with many investigators reporting similar cure rates for both groups of patients. Despite these marked improvements, numerous challenges still fac

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Norén, Nyström Ulrika. "Vascular density and bone marrow fibrosis in childhood acute lymphoblastic leukemia." Doctoral thesis, Umeå universitet, Pediatrik, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1642.

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Background: In childhood acute lymphoblastic leukemia (ALL), the cure rate has now reached 80% in the western world. Even so, 15¬–20% will die from the disease or treatment-related causes, among them children who did not present any known unfavorable features at diagnosis. Treatment of childhood ALL is risk-adapted, meaning that certain factors that are related to the child or the leukemic blasts stratifies to more or less intensive treatment. In this thesis, characteristics of the bone marrow (BM) stroma, reflecting the interaction between the leukemic cells and their microenvironment, were e

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25

Najmi, Laeya Abdoli. "Childhood Acute Lymphoblastic Leukemia : Genetic and Epigenetic Analysis of Archived Samples." Thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for laboratoriemedisin, barne- og kvinnesykdommer, 2012. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-19607.

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Acute lymphoblastic leukemia (ALL) is recognized as a fast-developing cancer originated from blood-progenitor cells. Blasts cells are immature cells which generate white blood cells (leukocytes), and it is the malignancy of the blast cells which lead to leukemias. The bone marrow is gradually filled up with these blasts and as a result, the production of healthy blood cells will be damaged. Malignant cells might also find their way to the blood circulation and have the ability to infiltrate vital organs as the brain and spinal cord. As the number of healthy bone marrow cells decrease, the deve

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26

Fidanza, Mario. "The influence of the immune system on acute lymphoblastic leukemia progression." Thesis, University of British Columbia, 2017. http://hdl.handle.net/2429/62124.

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The full abstract for this thesis is available in the body of the thesis, and will be available when the embargo expires.<br>Medicine, Faculty of<br>Experimental Medicine, Division of<br>Medicine, Department of<br>Graduate

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27

Wan, Haixia, and 万海霞. "Function of SOX7 in normal hematopoiesis and in acute lymphoblastic leukemia." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hdl.handle.net/10722/194606.

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The SOX (Sry-related HMG box) genes belong to a family of transcription factors containing a High-Mobility-Group box domain. In an initial screen, SOX7 was uniquely down-regulated in myeloid malignancies compared with most cases of precursor B-cell acute lymphoblastic leukemia (ALL) and normal bone marrow cell, leading us to examine the expression and function of SOX7 during normal hematopoietic differentiation and in acute lymphoblastic leukemia. By studying human umbilical cord blood (UCB), SOX7 expression in different hematopoietic lineages was evaluated by RT-PCR. SOX7 was preferentially e

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28

CAMPOLUNGO, DANIELE. "Dissecting the oncogenic mechanism of DUX4-IGH in acute lymphoblastic leukemia." Doctoral thesis, Università Vita-Salute San Raffaele, 2022. http://hdl.handle.net/20.500.11768/133060.

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In up to 10% of Acute Lymphoblastic Leukemia (ALL) patients, the disease is caused by translocations of the double homeobox 4 (DUX4) gene into the immunoglobulin heavy chain (IGH) locus, resulting in the overexpression in B-cell precursors of the DUX4-IGH fusion protein with an aberrant C-terminus. DUX4 is a transcription factor normally expressed in the germline and early embryo. Its aberrant reactivation in somatic cells mediates cellular toxicity by activating a pro-apoptotic transcriptional program. In contrast, DUX4-IGH displays transforming abilities and its expression induces leukemia.

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29

Boag, Joanne. "The molecular characterisation of childhood acute lymphoblastic leukaemia : gene expression profiles to elucidate leukaemogenesis /." Connect to this title, 2006. http://theses.library.uwa.edu.au/adt-WU2007.0160.

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30

Drake, Kylie Marie, and n/a. "Characterisation of the nature and timing of early events in childhood acute lymphoblastic leukaemia." University of Otago. Department of Biochemistry, 2007. http://adt.otago.ac.nz./public/adt-NZDU20070719.131918.

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Understanding the nature and timing of leukaemogenic events during the development of childhood acute lymphoblastic leukaemia (ALL) will enable intervention that could prevent ALL in the future. We hypothesised that 9p21 deletion in childhood ALL may unmask predisposing genetic events that would allow us to determine the "nature" of initiating events in childhood ALL; whereas the inclusion, or exclusion, of random �N� nucleotides in normal immunoglobulin gene rearrangements from the developing fetus and the expression of terminal deoxynucleotidyl transferase (TdT) in fetal lymphocytes may allo

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31

Shalapour, Shabnam [Verfasser]. "Leukemia-associated genetic aberrations in mesenchymal stem cells of children with acute lymphoblastic leukemia / Shabnam Shalapour." Berlin : Freie Universität Berlin, 2010. http://d-nb.info/1024054853/34.

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32

Dörrenberg, Mareike [Verfasser]. "Genetic and Epigenetic Landscapes of Pediatric Acute Lymphoblastic Leukemia Subtypes / Mareike Dörrenberg." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2020. http://d-nb.info/1203369808/34.

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33

Besada, Rana Hany. "BiTEs and CAR-Ts : immunotherapy in childhood B-cell acute lymphoblastic leukemia." Thesis, Massachusetts Institute of Technology, 2018. http://hdl.handle.net/1721.1/115699.

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Thesis: S.M., Massachusetts Institute of Technology, Department of Biology, 2018.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 18-21).<br>B-cell acute lymphoblastic leukemia is the most common pediatric cancer, responsible for the most cancer-related deaths in children. Advances in chemotherapy over the past half-century have steadily increased the remission and survival of children with B-cell acute lymphoblastic leukemia to nearly 90%. However, the problems of minimal residual disease and relapsed and refractory disease persist. Personalized, targete

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34

Wilder, Jayme. "The Role of AKT Signaling in T-Cell Acute Lymphoblastic Leukemia Relapse." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:17295893.

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Thousands of children and adults in the United States are diagnosed with T-cell acute lymphoblastic leukemia (T-ALL) annually. Less than 30% of children and 8% of adults will survive relapsed T-ALL. While relapsed tumor is often more aggressive and treatment resistant than primary disease, the genetic and molecular mechanisms underlying relapse are not well understood. In general, leukemias are composed of heterogeneous cells which evolve over time to drive cancer progression, therapy resistance, and ultimately relapse. To elucidate the mechanisms driving relapse in T-ALL, the phenotypic chara

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35

Grotel, Martine van. "Identification of prognostic genetic factors in pediatric T-cell acute lymphoblastic leukemia." [S.l.] : Rotterdam : [The Author] ; Erasmus University [Host], 2008. http://hdl.handle.net/1765/13286.

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36

Järviaho, T. (Tekla). "Germline predisposition to childhood acute lymphoblastic leukemia and bone marrow failure, and mitochondrial DNA variants in leukemia." Doctoral thesis, Oulun yliopisto, 2018. http://urn.fi/urn:isbn:9789526220437.

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Abstract Childhood acute lymphoblastic leukemia (ALL) is the most common cancer in children. The overall survival rate has reached to 90%. However, ALL still presents a significant disease burden and is a major cause for deaths in children. Recently, both inherited germline variants related to ALL susceptibility and somatic genetic variants forming novel subgroups of ALL have been discovered. In this thesis two families with familial ALL were studied. Constitutional heterozygous microdeletion at chromosome 7p12.1p13, including IKZF1, was discovered in the first family with intellectual impairm

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37

Boag, Joanne. "The molecular characterisation of childhood acute lymphoblastic leukaemia : gene expression profiles to elucidate leukaemogenesis." University of Western Australia. School of Paediatrics and Child Health, 2007. http://theses.library.uwa.edu.au/adt-WU2007.0160.

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[Truncated abstract] Acute lymphoblastic leukaemia (ALL) is the most common form of cancer that affects children and the leading cause of child cancer-related death. There have been dramatic improvements in the 5-year event free survival (EFS) for childhood ALL in recent years, with EFS reaching 75-90% for some forms of the disease. Despite this success, treatment for the disease is aggressive with numerous long and short-term side effects. Many cases of ALL are characterised by chromosomal defects including translocations, variations in chromosome number and the deletion of the tumour suppres

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D'Altri, Teresa 1984. "Understanding the molecular mechanisms involved in Notch1 induced T-cell acute lymphoblastic leukemia." Doctoral thesis, Universitat Pompeu Fabra, 2013. http://hdl.handle.net/10803/283475.

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39

Sentís, Carreras Inés 1990. "The Evolution of T-cell acute lymphoblastic leukemia in adult patients under treatment." Doctoral thesis, TDX (Tesis Doctorals en Xarxa), 2021. http://hdl.handle.net/10803/670544.

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Acute lymphoblastic leukemia (ALL) is a blood cancer characterized by a high proliferation and maturation arrest of the lymphoid precursors which can either be from B or T-cell lineage. In adult patients, this type of cancer is considered a rare disease and the outcome is worse than children, especially for those presenting the T-Cell ALL (T-ALL) type. In order to get insights on the evolution of adult T-ALL under therapy, we have whole genome sequenced leukemic samples at diagnosis and relapse of 19 adult patients with T-ALL who relapsed after standard treatment. We report the somatic driver

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Frost, Britt-Marie. "Chemotherapy in Childhood Acute Lymphoblastic Leukemia : In vitro cellular drug resistance and pharmacokinetics." Doctoral thesis, Uppsala University, Department of Women's and Children's Health, 2002. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2664.

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<p>The aims of the studies described in this thesis were to investigate the pharmacokinetics of and cellular resistance to chemotherapy as causes of treatment failure in childhood acute lymphoblastic leukemia (ALL).</p><p>Leukemic cells from 370 children with newly diagnosed ALL were tested by the Fluorometric Microculture Cytotoxicity Assay to measure their resistance to each of ten standard cytotoxic drugs. In the high-risk group, increased in vitro resistance to each of the drugs dexamethasone, etoposide and doxorubicin was associated with a worse clinical outcome. Combining the results for

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Landier, Wendy. "Predictors of Non-Adherence to Oral Chemotherapy in Children with Acute Lymphoblastic Leukemia." Diss., University of Hawaii at Manoa, 2010. http://hdl.handle.net/10125/22058.

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Overall survival for pediatric patients with acute lymphoblastic leukemia (A.L.L.) treated with contemporary therapy now exceeds 85%; however, approximately 20% will experience relapse. Since A.L.L. is the most common malignancy in children, relapsed patients comprise a large proportion of the total number of children with cancer. The prognosis for long-term survival following relapse is generally poor; thus, relapsed A.L.L. is a significant contributor to cancer-related mortality in children. Poor adherence to oral medication is a substantial problem in contemporary health care and may contr

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Naji, Fadhel Mohammed Lafta Alsaid. "Investigation of methylation-based markers for relapse prediction in childhood acute lymphoblastic leukemia." Thesis, University of Newcastle upon Tyne, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.722577.

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Acute lymphocytic leukemia (ALL) is the most common childhood cancer representing more than 80% of diagnosed childhood leukemia cases. More than half of these cases come from the high hyperdiploidy (HeH) and RUNX1-ETV6 (t (12; 21)) cytogenetic subgroups. Although HeH and ETV6-RUNX1 -XYX subgroups are considered to have a good prognosis, a significant number of relapses in these subgroups still occur. If molecular markers could be discovered which identify those at high risk of relapse within these groups, these patients could be treated with protocols used for high risk patients, with the hope

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Liu, Chi-Chao. "Alpha-integrin expression and function modify chemoresistance and immunogenicity of acute lymphoblastic leukemia." Thesis, University of British Columbia, 2017. http://hdl.handle.net/2429/60560.

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The overall survival rate for pediatric Acute Lymphoblastic Leukemia (ALL) is >85%, achieved mainly via multi-agent chemotherapy. However, therapeutic options remain limited for those experiencing relapse, thus understanding the causes for treatment failures remains an important priority. In this thesis, I investigate the underlying mechanisms that allow leukemic cells to escape chemotherapy. Specifically, I evaluate how integrin-mediated cell adhesion promotes tumor cell survival by increased pro-survival signaling, enhanced resistance to chemotherapeutics, and decreased presentation of immun

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44

Buchanan, Gray McKay. "Factors associated with psychosocial late effects in childhood survivors of acute lymphoblastic leukemia /." Full text available from ProQuest UM Digital Dissertations, 2006. http://0-proquest.umi.com.umiss.lib.olemiss.edu/pqdweb?index=0&did=1410676601&SrchMode=1&sid=2&Fmt=2&VInst=PROD&VType=PQD&RQT=309&VName=PQD&TS=1218547988&clientId=22256.

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MACRINI, JOSE LEONARDO RIBEIRO. "RELAPSE RISK ESTIMATION IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA BY USING NEURAL NETWORKS." PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 2004. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=5795@1.

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CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO<br>Esta tese propõe uma metodologia, baseada em procedimentos quantitativos, para estimação do risco de evento adverso (recaída ou morte) em crianças portadoras de Leucemia Linfoblástica Aguda (LLA). A metodologia proposta foi implementada e analisada utilizando dados de grupo de crianças diagnosticadas no Setor de Hematologia do Instituto de Puericultura e Pediatria Martagão Gesteira (IPPMG) da UFRJ e no Serviço de Hematologia Hospital Universitário Pedro Ernesto (HUPE) da UERJ que constituem uma considerável parcela dos caso

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Soto-Feliciano, Yadira M. (Yadira Marie). "PHF6 is a novel regulator of B-cell identity in acute lymphoblastic leukemia." Thesis, Massachusetts Institute of Technology, 2016. http://hdl.handle.net/1721.1/103165.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biology, 2016.<br>This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>Cataloged from student-submitted PDF version of thesis. Vita.<br>Includes bibliographical references.<br>Mutations in the zinc finger gene PHF6 are seen in approximately 20% of adult T-cell acute lymphoblastic leukemias and 3% of adult acute myeloid leukemias. The notable absence of PHF6 mutations in B-cell lineage malignancies has led to the hypothesis that PH

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Dutra, Luana Leticia Alves. "Evaluation of genes aurka and aurkb in pediatric patients with acute lymphoblastic leukemia." Universidade Federal do CearÃ, 2015. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=15477.

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Conselho Nacional de Desenvolvimento CientÃfico e TecnolÃgico<br>Acute lymphoblastic leukemia (ALL) is the most common malignancy of childhood. It is a hematologic malignant neoplasm derived from undifferentiated young lymphoid lineage cells that accumulate and replace the normal population of blood cells. The Aurora kinase genes A, B and C are involved in cell cycle and encode proteins of great importance in the regulation of the mitosis process - separation of sister chromatids during metaphase / anaphase. The aim of this study was to evaluate the AURKA and AURKB genes in pediatric patients

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Billah, Mohammad Ehtasham. "Classifying Microscopic Images for Acute Lymphoblastic Leukemia (ALL) using Bayesian Convolutional Neural Networks." Thesis, Örebro universitet, Handelshögskolan vid Örebro Universitet, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-67990.

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Cahu, Xavier. "Intrinsic and extrinsic factors promoting the growth of T-cell acute lymphoblastic leukemia." Paris 7, 2014. http://www.theses.fr/2014PA077218.

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Les leucémies aiguës lymphoblastiques T (LAL-T) sont des maladies des progéniteurs T qui surviennent chez l'enfant et le jeune adulte. Des facteurs intrinsèques et extrinsèques à la cellule blastique sous-tendent le développement leucémique. Les LAL-T humaines peuvent être étudiées in vivo après injection dans des souris immunodéficientes ou in vitro dans des systèmes de cocultures avec des cellules stromales MS5 surexprimant Delta-likel. Dans la première partie de cette thèse, nous avons étudié l'hétérogénéité de croissance dans ces deux modèles. Nos résultats montrent que la croissance est p

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Liem, Natalia Women's &amp Children's Health Faculty of Medicine UNSW. "The development of an in vivo model to study the biology and treatment of childhood acute lymphoblastic leukaemia (ALL)." Awarded by:University of New South Wales. Women's & Children's Health, 2007. http://handle.unsw.edu.au/1959.4/40537.

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Relapsed ALL remams one of the most common causes of death from disease in children. Broad-range drug resistance is often associated with relapse, although its underlying molecular mechanisms remained poorly understood. The aim of this thesis was to establish an in vivo model using the non-obese diabetic/severe combined immunodeficient (NOD/SCID) mouse strain, to facilitate the engraftment, expansion and characterisation of childhood ALL cells, obtained from patients at diagnosis or relapse. Mice were inoculated with leukaemia cells from patients' biopsies and engraftment was monitored by the

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