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Dissertations / Theses on the topic 'PH Dependent delivery system'

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Published: 7 June 2025

Last updated: 2 August 2025

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1

FERRAZ, Leslie Raphael de Moura. "Desenvolvimento e avaliação da liberação in vitro de drug delivery system pH-dependente à base de benznidazol e ZIF-8 visando a obtenção de uma terapia alternativa para a doença de Chagas." Universidade Federal de Pernambuco, 2017. https://repositorio.ufpe.br/handle/123456789/23771.

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Submitted by Rafael Santana (rafael.silvasantana@ufpe.br) on 2018-02-20T18:35:23Z No. of bitstreams: 2 license_rdf: 811 bytes, checksum: e39d27027a6cc9cb039ad269a5db8e34 (MD5) Dissertacao TIAGO FRANCA BARRETO versao final revisada com ficha.pdf: 1881406 bytes, checksum: 12e01eebda9019e211cef41ad935a421 (MD5)<br>Made available in DSpace on 2018-02-20T18:35:23Z (GMT). No. of bitstreams: 2 license_rdf: 811 bytes, checksum: e39d27027a6cc9cb039ad269a5db8e34 (MD5) Dissertacao TIAGO FRANCA BARRETO versao final revisada com ficha.pdf: 1881406 bytes, checksum: 12e01eebda9019e211cef41ad935a421 (MD5) P

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Song, Lei. "Development of a targeted nanoscale drug delivery system using pH-responsive DNA-nanoparticle conjugate." Thesis, University of Leeds, 2013. http://etheses.whiterose.ac.uk/5270/.

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Cancer is one of the most devastating diseases facing society, accounting for some 8 millions deaths worldwide in 2008 alone, and, more alarmingly, the number is predicted to increase to 13.1 million in 2030. Although conventional cancer treatments, such as radiotherapy and chemotherapy, have provided profound beneficial effects for millions of cancer patients, serious side effects cannot be avoided, mostly due to the lack of specific targeting of these treatments. A long-term goal for the pharmaceutical and healthcare industries is to develop intelligent drug delivery systems that can selecti

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3

Fischel-Ghodsian, F. "Modelling and simulation in the development of a polymeric glucose-dependent insulin delivery system." Thesis, University of Oxford, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.379989.

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4

Al-Mamari, Ahmed. "Biocontainment system for bacterial antigen delivery carriers." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/28793.

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Genetically modified organisms (GMOs) are confined physically in order to contain their spread in nature and to minimise chances of horizontal gene transfer. However, with the potential that GMOs hold as cheap, reliable and efficient micro-machines, their eventual uncontrolled release into the wider space is becoming more likely. Indeed, their application as environmental sensors is largely increasing. Nevertheless, the field of synthetic biology may also afford solutions to the problem. A major potential application of GMOs is the delivery of antigens to human and animal hosts, through the ut

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5

Pöhlmann, Christoph, Manuela Brandt, Dorothea S. Mottok, et al. "Periplasmic Delivery of Biologically Active Human Interleukin-10 in Escherichia coli via a Sec-Dependent Signal Peptide." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-137673.

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Interleukin-10 (IL-10) is a potent anti-inflammatory cytokine, with therapeutic applications in inflammatory bowel disease. For the in situ delivery of IL-10 by Escherichia coli as carrier chassis, a modified transporter was designed with the ability to secrete biologically active IL-10. De novo DNA synthesis comprised a 561-bp fragment encoding the signal sequence of the E. coli outer membrane protein F fused in frame to an E. coli codon-optimized mature human IL-10 gene under control of a T7 promoter. The construct was overexpressed in E. coli laboratory strains, E. coli BL21 (DE3) and E. co

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Pöhlmann, Christoph, Manuela Brandt, Dorothea S. Mottok, et al. "Periplasmic Delivery of Biologically Active Human Interleukin-10 in Escherichia coli via a Sec-Dependent Signal Peptide." Karger, 2012. https://tud.qucosa.de/id/qucosa%3A27748.

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Interleukin-10 (IL-10) is a potent anti-inflammatory cytokine, with therapeutic applications in inflammatory bowel disease. For the in situ delivery of IL-10 by Escherichia coli as carrier chassis, a modified transporter was designed with the ability to secrete biologically active IL-10. De novo DNA synthesis comprised a 561-bp fragment encoding the signal sequence of the E. coli outer membrane protein F fused in frame to an E. coli codon-optimized mature human IL-10 gene under control of a T7 promoter. The construct was overexpressed in E. coli laboratory strains, E. coli BL21 (DE3) and E. co

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7

Giret, Simon. "Nanoparticules de silice hybride à empreinte moléculaire comme transporteur pH-sensible de principes actifs." Thesis, Montpellier, Ecole nationale supérieure de chimie, 2014. http://www.theses.fr/2014ENCM0006.

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Ce travail de thèse s'inscrit dans le cadre de la recherche contre le cancer, l'un des enjeux majeurs de notre société. L'objectif est d'optimiser l'action des principes actifs notamment en réduisant leurs effets secondaires chez le patient. Pour cela nous souhaitons développer des nanotransporteurs siliciques pH-sensibles capables de s'accumuler spécifiquement dans les tumeurs solides grâce à l'effet EPR.Les travaux présentés dans ce manuscrit décrivent donc la synthèse de nouveaux dérivés actifs du 5-Fluorouracile capables de former un complexe via liaisons H avec un précurseur de silice hyb

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Fonseca, Filipa Ribeiro da. "Establishment of bioengineered glucose-responsive nanoparticles for type 2 diabetes mellitus therapy." Master's thesis, Universidade Nova de Lisboa. Instituto de Tecnologia Química e Biológica António Xavier, 2019. http://hdl.handle.net/10362/130074.

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Dissertation presented to obtain the Master degree in Biochemistry for Health<br>"Type 2 diabetes mellitus (T2DM) is one of the biggest health problems in the world. Glucagon like peptide-1, an endogenous gastrointestinal incretin hormone that stimulates insulin secretion, is considered an attractive therapeutic agent for T2DM treatment. Nevertheless, its short half-life has led to the development of longer half-life GLP-1 analogues, as exenatide. Still, current dosage forms for exenatide delivery are not exempt of shortcomings. Nanotechnology-based systems may offer several advantages over co

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9

Bastos, Mônica Danielle Ribeiro. "Monitoramento do pH e dos níveis de inserção óssea antes e após tratamento com sistemas bioadesivos poliméricos para a liberação modificada de metronidazol intrabolsa periodontal." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/58/58131/tde-23022016-150459/.

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O objetivo deste estudo foi avaliar clinicamente em humanos sistemas semissólidos (géis) e filmes contendo sal de metronidazol e conjugado de benzoato de metronidazol associados à raspagem e alisamento radicular (RAR), para o tratamento de periodontite. Foram avaliados o pH do fluido crevicular, os níveis clínicos de inserção óssea de suporte aos dentes envolvidos no tratamento periodontal, antes e após os tratamentos, além do perfil de liberação dos fármacos por meio de cromatografia líquida de alta eficiência (CLAE). Participaram do estudo 45 pacientes da Faculdade de Odontologia de Ribeirão

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10

Bergström, David, and Jacob Heyle. "Förhindra förseningar i distributionscentraler : Med syfte att öka leveransprecision." Thesis, Tekniska Högskolan, Högskolan i Jönköping, JTH, Industriell organisation och produktion, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-37813.

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Abstract Purpose – The purpose of the study is to investigate how distribution centers can prevent delays to achieve higher on-time delivery. To fulfill the purpose of the study three study questions have been conducted: • What factors causes delays in distribution centers? • Why do delays occur in distribution centers? • How can distribution centers prevent delays to achieve higher on-time delivery? Method – A qualitative approach has been used throughout the study to enable fulfilment of the study´s purpose. The study has implemented a case study at a distribution center to investigate

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Liu, Juan. "Nouveaux systèmes nanométriques et ph dépendant pour le transport de médicaments contre les phénomènes de résistances." Thesis, Aix-Marseille, 2016. http://www.theses.fr/2016AIXM4072.

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La résistance aux médicaments constitue un obstacle majeur pour le traitement du cancer. Les systèmes nanoparticulaires de délivrance de médicaments (nanoparticule drug delivery system, NDDS) sont pressentis pour apporter un nouvel espoir dans le traitement du cancer afin de surmonter la résistance aux médicaments en délivrant spécifiquement l’agent anticancéreux dans la lésion tumorale par effet EPR. Cela aura pour effet d’augmenter la concentration locale en médicaments et par conséquent d’améliorer l'efficacité thérapeutique tout en épargnant les tissus sains afin d'éviter les effets second

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12

Liu, Juan. "Nouveaux systèmes nanométriques et ph dépendant pour le transport de médicaments contre les phénomènes de résistances." Electronic Thesis or Diss., Aix-Marseille, 2016. http://www.theses.fr/2016AIXM4072.

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La résistance aux médicaments constitue un obstacle majeur pour le traitement du cancer. Les systèmes nanoparticulaires de délivrance de médicaments (nanoparticule drug delivery system, NDDS) sont pressentis pour apporter un nouvel espoir dans le traitement du cancer afin de surmonter la résistance aux médicaments en délivrant spécifiquement l’agent anticancéreux dans la lésion tumorale par effet EPR. Cela aura pour effet d’augmenter la concentration locale en médicaments et par conséquent d’améliorer l'efficacité thérapeutique tout en épargnant les tissus sains afin d'éviter les effets second

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13

Achuo, George. "Partner satisfaction and renewal likelihood in consumer supported agriculture (CSA) : a case study of The Equiterre CSA network." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=19555.

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14

Dias, Tiago André Malacho. "Effect of plasticisers on the pH-dependency of an eudragit based drug delivery system." Master's thesis, 2014. http://hdl.handle.net/10451/38741.

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Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2014<br>With the advent of new drug delivery systems, various drug molecules have been revived of their therapeutic and commercial benefits. Polymers have played an indispensable role in this advancement, facilitating the development of systems which deliver the drug at desired site of action in optimum therapeutic concentration. Eudragit polymers, for example, have received special attention. Methacrylic acid Eudragit polymers have been the focus of numerous studies due to their pHdep

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15

Chen, Hung Hao, and 陳宏豪. "pH-Triggered Micellar Drug Delivery System for Application in Cancer Therapy." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/60612014209494187643.

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碩士<br>國立交通大學<br>應用化學系所<br>95<br>A novel mixed micelle comprised of poly(D,L-lactide)-g-poly(N-vinylimidazole-co-N-vinyl-2-pyrrolidone) (PLA-g-P(NVI-co-NVP)) graft copolymer with methoxy poly(ethylene glycol)-b-poly(D,L-lactide) (mPEG-PLA) diblock copolymer was successfully developed for application in cancer therapy. The mixed micelle had an biocompatibility, biodegradab, pH-triggered inner core of P(NVI-co-NVP)-g-PLA to enable intracellular drug delivery and an extended hydrophilic outer shell of mPEG to hide the inner core. PNVI in backbone of graft copolymer exhibited pH-triggered property,

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Fujiwara, Mitsuko. "Characterization of pH-dependent poly(acrylic acid)-vesicle interaction and its application in cellular drug delivery." Thesis, 1993. https://thesis.library.caltech.edu/7284/1/Fujiwara_m_1993.pdf.

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<p>Polymers can be used to control drug targeting and drug release from phospholipid vesicles through changes in pH. Understanding the effect of polymers on vesicle properties is important in obtaining a better control over drug delivery using phospholipid vesicles. The pH-dependent interaction of poly(acrylic acid) (PAA) with phosphatidylcholine (PC) vesicles (bilayers) and monolayers was investigated to elucidate the mechanism of P AA-induced vesicle destabilization. PAA induced aggregation of vesicles below pH 4.6 and lipid intermixing of vesicles below pH 4.1. Mixing of aqueous contents wa

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Huang, Yu-Hsin, and 黃于馨. "Development of pH-sensitive polymeric mixed micelles for anticancer drug delivery system." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/hqb92j.

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18

Hu, Pei-Yu, and 胡培瑜. "Investigation of pH-sensitive liposomal formulation of Mitomycin C for drug delivery system." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/v3vq32.

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碩士<br>高雄醫學大學<br>藥學系碩士班<br>103<br>Mitomycin C is a potent anticancer drug. But the severe side effect like cumulative myelosuppression and nephrotoxicity limit its therapeutic efficacy. Moreover, the clinical use of Mitomycin C is significantly hindered due to the rapid elimination from the body. The half-life of Mitomycin C is about 23~78 minutes. The purpose of this study was to formulate the pH-sensitive liposomes for cancer therapy. DOPE, CHEMS and DSPE-PEG2000-folate were used as materials to prepare pH-sensitive liposomes. The physicochemical characteristics of pH-sensitive liposomes : pa

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19

Zeng, Yi-Fang, and 曾意芳. "Switchable gene or virus delivery system using pH-sensitive polymeric carrier for biomedical application." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/89528602819538462926.

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博士<br>國立臺灣大學<br>生物科技研究所<br>101<br>Controlled gene delivery is a highly activated approach using viral or nonviral carriers. We used different strategies of gene transfer based on polymeric matrix or carrier for improved their efficiency. In the section of Chapter 2, we designed a biodegradable and pH sensitive polymeric matrix for localized delivery of recombinant adeno-associated virus serotype 2 (rAAV2). The rAAV2 containing the green fluorescent protein gene (rAAV2-GFP) were loaded into poly(ethylene glycol) (PEG) hydrogels, with and without incorporation of poly-L-histidine (polyHis). The

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20

Hung, Huei-Ling, and 洪惠苓. "The Effect of Global Budget System on Integrated Delivery Services for Ventilator-Dependent Patients." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/86308896799069792707.

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碩士<br>高雄醫學大學<br>醫務管理學研究所碩士在職專班<br>98<br>Purpose According to 2007 National Health Insurance (NHI) statistics, up to 66,080 ventilator-dependent patients (who used ventilators for consecutive 21 days and above) met hospitalization criteria, with NHI-covered admission charges amounting to as high as NT$13.7 billion. This study explores the effect of implementation of integrated delivery services (IDS) including 1 to 2 years following the IDS implementation (i.e. 1 to 2 years prior to implementation of the Global Budget System), and 1 to 2 and 3 to 4 years following the implementation of Global

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Oliveira, Catarina Martins Bento. "Preparation and characterization of a time-dependent drug delivery system by tablet press-coating." Master's thesis, 2019. http://hdl.handle.net/10451/43440.

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Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2019<br>Os sistemas de libertação tempo-dependente são desenhados para oferecer uma rápida libertação ou uma libertação prolongada do fármaco após um tempo programado, denominado de lag time. Estes sistemas apresentam diversas aplicações, por exemplo, como formulações cronoterapêuticas ou para obtenção de libertação de um fármaco no cólon. Este trabalho teve como objetivo o desenvolvimento de comprimidos revestidos por compressão com libertação dependente do tempo, contendo prednisona n

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Wu, Chao Ling, and 吳昭玲. "The Impact of the Integrated Delivery System on Health Utilization for Ventilator Dependent Patients." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/b38ava.

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碩士<br>長庚大學<br>商管專業學院碩士學位學程在職專班醫務管理組<br>105<br>To improve the healthcare and medical utilization of patients requiring prolonged mechanical ventilation, the Bureau of National Health Insurance has implemented “National Health Insurance Managed Care Demonstration Program for Ventilator Dependent Patients, or Integrated Delivery System (IDS), since July 1st, 2000. The data sources of the present study were from the National Health Insurance Research Database (NHIRD), including the registry of catastrophic illnesses patients, claims data from details of inpatient orders (DO), and inpatient expen

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Lee, Kuan-Yi, та 李冠儀. "Development of α-Tocopheryl Succinate (α-TOS)-containing pH sensitive drug delivery system for cancer therapy". Thesis, 2015. http://ndltd.ncl.edu.tw/handle/xpst4c.

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博士<br>國立陽明大學<br>生物醫學工程學系<br>104<br>α-Tocopheryl Succinate (a-TOS) has been widely studied because of their anti-tumor properties. It has been demonstrated that a-TOS molecules could selectively kill cells with a malignant or transformed phenotype. Additionally, a-TOS and Dox could exhibit cooperated eﬀect to increase the anti-cancer eﬃcacy via enhancing cellular uptake level of Dox.In this study, three different micelle drug delivery systems were developed. a-TOS containing polymers were applied to self-assemble into micelles and deeply evaluated the anti-tumor therapeutic efficacy. The first

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胡宜禎. "Beads with a Thermo-sensitive Porous-shell and a pH-sensitive Core as a Dual-switched Drug Delivery System." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/72516211526629504593.

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Hsu, Ning-Yu, and 徐寧妤. "Investigation of pH-Sensitive Vitamin E-contained Polymeric Micelles to Induce Apoptosis for Cancer Cells in Drug Delivery System." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/17753549876747735261.

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碩士<br>國立陽明大學<br>醫學工程研究所<br>102<br>α-Tocopheryl succinate (α-TOS), an analogue of vitamin E, can induce apoptosis in cancer cells, while exhibiting low toxicity in normal cells. In this study, the block copolymer, methoxy poly(ethylene glycol)-block-poly (hydroxypropyl methacrylate) (mPEG-b-PHPMA) was designed as the hydrophilic main chain. The hydrophobic α-TOS and pH-sensitive histidine were grafted onto the block copolymer by coupling reaction, forming comb-like copolymer, mPEG-b-P(HPMA-g-α-TOS-g- His). The copolymers were self-assembled into polymeric micelles which loaded with both antica

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Mayet, Naeema. "Inflammatory dependent bioresponsive smart transdermal delivery system incorporating susppended nanofibrous mats as a platform for wound healing." Thesis, 2016. http://hdl.handle.net/10539/21260.

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A thesis submitted to the Faculty of Health Sciences, University of the Witwatersrand, in fulfilment of the requirements for the degree of Doctor of Philosophy Department of Pharmacy and Pharmacology, Faculty of Health Sciences, University of the Witwatersrand, South Africa Johannesburg 2016<br>The perception of wound healing within the current decade goes beyond the straightforward assertion of the three phases assembling the wound healing cascade. Healing of wounds is a complex process that involves a dynamic series of interactions and reactions and requires a collaboration of the many cell

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Lin, Yi-Jou, and 林儀柔. "A Two-Step Controlled Release System Based on The Microneedle array filled with pH-sensitive PLGA hollow microspheres (HMS) for transdermal drug delivery." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/28118117724661515154.

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碩士<br>國立清華大學<br>奈米工程與微系統研究所<br>99<br>Transdermal delivery is an attractive alternative of drug delivery. Comparing to the conventional drug delivery techniques using pills or injections, this approach avoids degradation in the gastrointestinal tract and the pain of injections. But it is limited by the low permeability of skin because the stratum corneum (SC) in the upper skin (10-20 μm) is the main barrier. Hence, we used the Bio-MEMS technique to make microneedle array patch to inset into skin. This microneelde array patch could easily cross the SC but not so long that reach the deeper tissue

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Simoes, Monica Patricia Gaspar. "Desenvolvimento e caracterização de sistemas inteligentes para de libertação controlada: complexos 1polímero-lipossoma (CPL)." Master's thesis, 2015. http://hdl.handle.net/10316/40248.

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Dissertação de Mestrado Integrado em Engenharia Química apresentada à Faculdade de Ciências e Tecnologia da Universidade de Coimbra<br>Este trabalho teve como objetivo o desenvolvimento e caracterização de sistemas inteligentes para libertação controlada, baseados em complexos polímero-lipossoma (CPLs). O polímero hidrófilo selecionado foi o poli(ácido acrílico) (PAA) e a sua incorporação nos lipossomas foi obtida por modificação do mesmo com colesterol (CHO), que possui uma grande afinidade com as bicamadas lipídicas presentes. A síntese de CHO-PAA foi realizada por hidrólise do poli(acr

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Lin, Yen-Tang, and 林燕堂. "Outcome Evaluation of the Respiratory Care Ward under Integrated Delivery System (IDS) for Long-term Ventilator-dependent Patients in Taiwan- Experiences from Seven Regional Hospitals in Central-Taiwan." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/s5v5y6.

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碩士<br>長榮大學<br>醫務管理學研究所<br>96<br>Background Since 1998 when the Bureau of National Health Insurance (NHI) launched the Integrated Delivery System (IDS) for ventilator-dependent patients, respiratory care services have been paid by capitation and respiratory care wards have increased from 1,046 beds in 2001 to 3,256 beds in October 2003, and then to 4,511 beds in November 2005. The number of holders of IC Card for Severe Illness (Long-term Ventilator Dependence) increased from 6,111 in January 1998 to 25,805 in August 2003, or 3.2 times growth. Hence, NHI adopted co-payment and capitation, and i

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LO, PEI-YING, та 羅珮瑛. "PH-induced Controlled Release of Condensed Polypeptide Drug Balls Split from Drug Delivery System as a New Efficient Strategy for Cancer Inhibition(首字為專有名詞不適合大寫)". Thesis, 2019. http://ndltd.ncl.edu.tw/handle/2jc95w.

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碩士<br>國立臺北教育大學<br>自然科學教育學系<br>107<br>Nanotechnology gets more and more popular in many biomedical applications. Peptide self-assembled nanodrug is one of the most promising applications among them because its enhanced permeability and retention effect (EPR). Peptide-originated structures have tremendous advantages including its intrinsic low toxicity, high translation values, excellent biocompability and biodegradability, high tissue permeability, nonimmunogenicity,tunable bioactivity and stimuli responsive at tumor areas. Herein, we report the development of a high drug loading, polypeptide a

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