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Journal articles on the topic 'PH Dependent delivery system'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Ambekar, Sakshi, Shrikant Gadhe, Aniket Shinde, Rushikesh Sonawane, Amit Kakad, and M. R. N. Shaikh. "Overview: Review on colon drug delivery system." Journal of Pharmaceutical and Biological Sciences 12, no. 2 (2025): 79–83. https://doi.org/10.18231/j.jpbs.2024.013.

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The goal of this review is to comprehend existing methods for colon-targeting dosage forms that use microbially triggered (such as prodrugs and polysaccharide-based systems), pressure-dependent, pH-sensitive, osmotically controlled, and timed release systems. Over the past 20 years, colonic-focused drug transfer has become more and more significant due to the capacity to transfer therapeutic peptides and proteins as well as medications for the treatment of various colon disorders. With varying degrees of effectiveness, a sort of traditional approach that takes into account prodrugs, pH, time-d

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Pawłowski, Łukasz. "pH-dependent composite coatings for controlled drug delivery system - Review." INŻYNIERIA MATERIAŁOWA 1, no. 3 (2019): 4–9. http://dx.doi.org/10.15199/28.2019.3.1.

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3

Yang, Mingshi, Fude Cui, Bengang You, et al. "A novel pH-dependent gradient-release delivery system for nitrendipine." Journal of Controlled Release 98, no. 2 (2004): 219–29. http://dx.doi.org/10.1016/j.jconrel.2004.04.022.

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4

Yang, Mingshi, Fude Cui, Bengang You, Liang Wang, Peng Yue, and Yoshiaki Kawashima. "A novel pH-dependent gradient-release delivery system for nitrendipine." International Journal of Pharmaceutics 286, no. 1-2 (2004): 99–109. http://dx.doi.org/10.1016/j.ijpharm.2004.08.007.

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5

Bi, Yu Shui, Xiao Xiao Zhang, Xiao Qun Cao, and Xian Feng Meng. "Research and Application of Oral Colon Targeted Drug Delivery System." Advanced Materials Research 1053 (October 2014): 456–60. http://dx.doi.org/10.4028/www.scientific.net/amr.1053.456.

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Oral colon targeted drug delivery system can be divided into pH dependent, time-dependent, enzymatic degradation etc. according to the ways of drug delivery. Mechanism of drug delivery, preparation method and application of oral colon targeted drug delivery system were introduced. In addition, it previewed the research direction of colon targeted drug delivery in the future, to provide a reference for the targeted new dosage form.

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Qi, Meiling, Peng Wang, and Dezheng Wu. "A Novel pH- and Time-Dependent System for Colonic Drug Delivery." Drug Development and Industrial Pharmacy 29, no. 6 (2003): 661–67. http://dx.doi.org/10.1081/ddc-120021315.

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7

Gvozdeva, Yana, and Radiana Staynova. "pH-Dependent Drug Delivery Systems for Ulcerative Colitis Treatment." Pharmaceutics 17, no. 2 (2025): 226. https://doi.org/10.3390/pharmaceutics17020226.

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Inflammatory bowel diseases (IBDs), such as ulcerative colitis (UC) or Crohn’s disease, are becoming a growing global problem due to the limitations of current treatments, which fail to address the needs of patients effectively. UC is characterized by the widespread inflammation of the mucosal lining, affecting both the rectum and the entire length of the colon. Over the past forty years, traditional treatments for IBDs have primarily relied on anti-inflammatory drugs and immunosuppressive medications. Treatment could be more effective if drugs could be specifically targeted to act directly on

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Gao, Ruijuan, Rajendra Narayan Mitra, Min Zheng, Kai Wang, Jesse Christine Dahringer, and Zongchao Han. "Developing Nanoceria-Based pH-Dependent Cancer-Directed Drug Delivery System for Retinoblastoma." Advanced Functional Materials 28, no. 52 (2018): 1806248. http://dx.doi.org/10.1002/adfm.201806248.

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9

Shelke Amruta P, Wagh Priti A, Nikam Sakshi M, and Bhosale Jaydeep J. "Pulsatile drug delivery system: A review." World Journal of Biology Pharmacy and Health Sciences 21, no. 2 (2025): 457–66. https://doi.org/10.30574/wjbphs.2025.21.2.0187.

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Pulsatile Drug Delivery Systems (PDDS) are increasingly recognized for their ability to deliver drugs at specific times, tailored to the pathophysiological needs of a disease. This approach enhances therapeutic efficacy and patient compliance. The core concept of PDDS involves a defined lag-time before a rapid drug release, which can be particularly beneficial for treatments requiring synchronization with the body’s natural circadian rhythms. By aligning peak plasma concentrations with these biological cycles, PDDS can improve both the safety and effectiveness of drugs over a 24-hour period. T

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10

Rabišková, Miloslava, Jiří Třináctý, Tomáš Sýkora, and Petr Doležal. "Post-ruminal delivery systems." Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis 52, no. 2 (2004): 143–48. http://dx.doi.org/10.11118/actaun200452020143.

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Livestock industry and organization for animal wellfare underlie the need for drug and nutrient delivery systems for ruminants that protect active ingredients from ruminal fermentation. To deliver drugs or nutrients directly to the small intestine for absorption, therapeutical systems must meet the safety and cost criteria. An effective post-ruminal delivery system is a prerequisite to implement some significant advances in animal nutrition and health in ruminants. Comparing with the products developed for human use, cost constraints have impeded the development of effective post-ruminal deliv

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Quan, Ji Shan, Hu Lin Jiang, Yun Jaie Choi, Mi Kyong Yoo, and Chong Su Cho. "Thiolated Eudragit-Coated Chitosan Microspheres as an Oral Drug Delivery System." Key Engineering Materials 342-343 (July 2007): 445–48. http://dx.doi.org/10.4028/www.scientific.net/kem.342-343.445.

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The aim of this study is to prepare mucoadhesive chitosan microspheres for protein drug to deliver to intestine through oral administration. The thiolated Eudragit was synthesized by reaction between L-cysteine hydrochloride and Eudragit® L-100. About 8 mol-% of cysteine was introduced to the Eudragit-cysteine conjugate. The conjugate was used to coat bovine serum albumin (BSA)-loaded chitosan microspheres. The average particle sizes of BSA-loaded thiolated Eudragit-coated chitsoan microspheres (TECMs) were 4.06±0.74 .m and the uniform sizedistribution was shown. The in vitro release of BSA fr

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12

Lanz-Landázuri, Alberto, Antxon Martínez de Ilarduya, Montserrat García-Alvarez та Sebastián Muñoz-Guerra. "Poly(β,L-malic acid)/Doxorubicin ionic complex: A pH-dependent delivery system". Reactive and Functional Polymers 81 (серпень 2014): 45–53. http://dx.doi.org/10.1016/j.reactfunctpolym.2014.04.005.

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13

Khan, M. Zahirul I., Željko Prebeg, and Nevenka Kurjaković. "A pH-dependent colon targeted oral drug delivery system using methacrylic acid copolymers." Journal of Controlled Release 58, no. 2 (1999): 215–22. http://dx.doi.org/10.1016/s0168-3659(98)00151-5.

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14

Soni, Murari Lal, Kamta Prasad Namdeo, Sunil Kumar Jain, et al. "pH-Enzyme Di-dependent Chronotherapeutic Drug Delivery System of Theophylline for Nocturnal Asthma." CHEMICAL & PHARMACEUTICAL BULLETIN 59, no. 2 (2011): 191–95. http://dx.doi.org/10.1248/cpb.59.191.

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15

Harris, T. L., C. J. Wenthur, A. Diego-Taboada, G. Mackenzie, T. S. Corbitt, and K. D. Janda. "Lycopodium clavatum exine microcapsules enable safe oral delivery of 3,4-diaminopyridine for treatment of botulinum neurotoxin A intoxication." Chemical Communications 52, no. 22 (2016): 4187–90. http://dx.doi.org/10.1039/c6cc00615a.

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16

Sharma, Pooja, Anuj Chawla, and Pravin Pawar. "Design, Development, and Optimization of Polymeric Based-Colonic Drug Delivery System of Naproxen." Scientific World Journal 2013 (2013): 1–12. http://dx.doi.org/10.1155/2013/654829.

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The aim of present investigation deals with the development of time-dependent and pH sensitive press-coated tablets for colon specific drug delivery of naproxen. The core tablets were prepared by wet granulation method then press coated with hydroxypropyl cellulose (HPC) or Eudragit RSPO : RLPO mixture and further coated with Eudragit S-100 by dip immerse method. Thein vitrodrug release study was conducted in different dissolution media such as pH 1.2, 6.8, and 7.4 with or without rat caecal content to simulate GIT conditions. Surface morphology and cross-sectional view of the tablets were vis

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17

Li, Dalong, Yilin Chen, Zhongyang Zhang, and Menglin Chen. "Mesoporous Nanofibers Mediated Targeted Anti-cancer Drug Delivery." MRS Advances 3, no. 50 (2018): 2991–3002. http://dx.doi.org/10.1557/adv.2018.425.

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ABSTRACTTumor tissue has different acidity compared to normal tissue. Localized drug delivery that release chemotherapeutic medications upon stimulation via pH changes is a promising strategy in cancer therapy for adjuvant therapies after surgical resection to reduce the risk of local recurrence. In this study, a mesoporous nanofibrous system with acidic pH-triggered “caps” has been for the first time developed for localized on-demand drug release to target tumor cells, without biological damage to normal cells while maintaining their structural integrity to support future tissue regeneration.

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18

Chen, Jun, Xiaojian Li, Liqian Gao, Yi Hu, Wen Zhong, and Malcolm MQ Xing. "A Facile Strategy for In Situ Controlled Delivery of Doxorubicin with a pH-Sensitive Injectable Hydrogel." Nano LIFE 04, no. 03 (2014): 1441001. http://dx.doi.org/10.1142/s1793984414410013.

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In light of the challenges along with the traditional intravenous administration of chemotherapeutics, injectable hydrogel-drug system emerges as a powerful tool for noninvasive and in situ controlled-release of drugs. Herein, we report a novel strategy of drug delivery system with pH responsive injectable hydrogels by taking advantages of two biomaterials. The first one is a pH sensitive polymer-drug (prodrug) conjugate, poly (ethylene glycol)–doxorubicin (MPEG–DOX) with hydrazone linkage. This prodrug interacted with a second biomaterial, α-cyclodextrin (α-CD) under mild conditions and subse

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19

Youm, Ibrahima, Malika Lahiani-Skiba, Frederic Bounoure, and Mohamed Skiba. "Combination of Time-Dependent and pH-Dependent System for Intestinal Delivery of 4-Aminosalicylic Acid Based Pellets." Letters in Drug Design & Discovery 6, no. 4 (2009): 278–85. http://dx.doi.org/10.2174/157018009788452555.

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20

Xiao, Qinle, Changjun Wan, Zhe Zhang, et al. "A pH-Responsive Ti-Based Local Drug Delivery System for Osteosarcoma Therapy." Journal of Functional Biomaterials 15, no. 10 (2024): 312. http://dx.doi.org/10.3390/jfb15100312.

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Osteosarcoma is one of the major bone cancers, especially for youngsters. The current treatment usually requires systemic chemotherapy and the removal of bone tumors. Titanium (Ti)-based implants can be modified as local drug delivery (LDD) systems for controllable and localized chemotherapeutic drug release. In this work, a pH-responsive Ti-based LDD prototype was designed by introducing polydopamine (PDA) to release doxorubicin (DOX) around osteosarcoma cells with low pH. Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and a contact angle meter were applie

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21

K. S., Meena, Sonia K, and Alamelu Bai S. "Doxorubicin Loaded Nanoparticle Consisting of Chitosan and Mannose Modified Graphene Oxide for Intracellular Drug Delivery and Anti-tumor Activity." International Journal of Pharmaceutical Sciences and Nanotechnology 13, no. 5 (2020): 5155–64. http://dx.doi.org/10.37285/ijpsn.2020.13.5.13.

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In order to develop the efficiency and the specificity of anticancer drug delivery, we have designed an innovative nanocarrier. The nanocarrier system comprises of a multifunctional graphene oxide nanoparticle-based drug delivery system (GO-CS-M-DOX) as a novel platform for intracellular drug delivery of doxorubicin (DOX). Firstly, graphene oxide (GO) was synthesized by hummer’s method whose surface was functionalized by chitosan (CS) in order to obtain a more precise drug delivery, the system was then decorated with mannose (M). Further conjugation of an anti-cancer drug doxorubicin to the na

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22

Ghosh, Soumyadip, Subhabrota Majumdar, and Debgopal Ganguly. "A brief review on colon-specific drug delivery system for targeting to colonic region." Journal of Applied Pharmaceutical Research 9, no. 4 (2021): 9–15. http://dx.doi.org/10.18231/j.joapr.2021.9.15.

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Drug delivery to the colonic region refers to the drug that should have to released in the colonic environment instead of released in the upper gastrointestinal tract. To reach the site-specificity of the local treatment of the colon such as amoebiasis, colorectal cancer, and inflammatory bowel disease the target-specific drug delivery played an important role. To the establishment of the target-specific drug delivery to the colon, the various approach that has been explored include pH-dependent polymer, time-dependent, and bacteria-dependent drug delivery approach. Nanotechnology has been gai

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23

García-Couce, Jomarien, Nancy Bada-Rivero, Orestes D. López Hernández, et al. "Dexamethasone-Loaded Chitosan Beads Coated with a pH-Dependent Interpolymer Complex for Colon-Specific Drug Delivery." International Journal of Polymer Science 2019 (March 18, 2019): 1–9. http://dx.doi.org/10.1155/2019/4204375.

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Chitosan (CS) microparticles loaded with dexamethasone were prepared by spray drying, followed by coating with a pH-dependent interpolymer complex based on poly(acrylic acid)/poly(vinyl pyrrolidone) using an water-in-oil emulsion technique. The aim of this research was to evaluate the influence of PAA/PVP coating on the release of dexamethasone from loaded chitosan microparticles, in simulated gastric fluid (SGF, pH=1.2) and simulated intestinal fluid (SIF, pH=6.8). The release of dexamethasone from uncoated loaded CS microparticles was similar in both fluids, and almost complete release of th

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24

Ch, Ramesh, Ramu B, and Rajkamal B. "Formulation of Colon Specific Didanosine Enteric Coated Matrix Tablets Using pH Sensitive Polymer." Pharmaceutical and Chemical Journal 3, no. 2 (2016): 207–20. https://doi.org/10.5281/zenodo.13754051.

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The objective of present study is to develop the colon specific Didanosine enteric coated matrix tablets using release retardant polymer and pH sensitive polymer Eudragit L100 that retard the liberation of drug in upper gastro intestinal system and also show progressive release in colon. The influence of core tablet compositions, polymer combination ratios and coating levels on the in vitro release rate of Didanosine from coated tablets was investigated. The results showed that less than 10% drug was released in 0.1 N HCl within 2 hr, and about 90% of the drug was released in the pH 7.4 phosph

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Pawar, Pravin, and Gharge Varsha. "Formulation and Evaluation of Mesalamine Loaded pH Dependent Colon Specific Pulsatile Drug Delivery System." Current Research in Pharmaceutical Sciences 8, no. 3 (2018): 244–53. http://dx.doi.org/10.24092/crps.2018.080301.

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26

Gorakshanath, Ghugarkar Prasad. "FORMULATION, DEVELOPMENT AND OPTIMISATION OF PH. DEPENDENT DRUG DELIVERY SYSTEM CONTAINING PROTON PUMP INHIBITOR." Journal of Medical pharmaceutical and allied sciences 10, no. 6 (2021): 3878–82. http://dx.doi.org/10.22270/jmpas.v10i6.1632.

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The present study was involving the targeting the Rabeprazole formulation at site specificity. Peptic ulcer mostly occurs in the lower part of the gastrointestinal tract. Proton pump inhibitors category drugs mainly used to cure peptic ulcer. As most of proton pump inhibitors degrades in acidic condition in stomach, the present study mainly focus on targeting site specificity without degradation of drug in stomach. Rabeprazole and selected excipients was tested for reformulation study as well as for analytical techniques like Ultra Violet Visible Spectroscopy, Fourier Transform Infrared Spectr

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27

Khan, Javed, Aatif Khan, Aman Khan, Danish Khan, Abdul Hayee Shaikh, and Mirza Salman Baig. "In situ Gel: A Promising Ocular Drug Delivery System." International Journal of Advancement in Life Sciences Research 07, no. 03 (2024): 65–77. http://dx.doi.org/10.31632/ijalsr.2024.v07i03.006.

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The eye is a vital organ, faces challenges in drug delivery with traditional ophthalmic formulations due to the rapid loss of medications before reaching the cornea. This review explores novel drug delivery systems for ocular administration, emphasizing innovative dosage forms, i.e., in situ gels. This system aims to prolong drug contact time in the eyes, overcoming bioavailability issues associated with conventional delivery methods. The article further delves into in situ gelation approaches, highlighting pH-triggered, temperature-dependent, and ion-activated systems. It explores the use of

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Lazar, Geza, Fran Nekvapil, Branko Glamuzina, et al. "pH-Dependent Behavior of Novel 5-FU Delivery System in Environmental Conditions Comparable to the Gastro-Intestinal Tract." Pharmaceutics 15, no. 3 (2023): 1011. http://dx.doi.org/10.3390/pharmaceutics15031011.

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A biogenic carrier for 5-fluorouracil (5-FU) loading and subsequent tableting as a new drug formulation for slow release has been proposed using the biomineral from blue crab carapace. Due to its highly ordered 3D porous nanoarchitecture, the biogenic carbonate carrier could achieve increased effectiveness in colorectal cancer cure provided that the formulation would successfully pass through the gastric acid conditions. Following the recently proven viability of the concept by demonstrating the slow release of the drug from the carrier using the highly sensitive SERS technique, here we invest

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An, Jinxia, Xiaomei Dai, Yu Zhao, et al. "A biodegradable and fluorescent nanovehicle with enhanced selective uptake by tumor cells." Polymer Chemistry 6, no. 36 (2015): 6529–42. http://dx.doi.org/10.1039/c5py00795j.

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The tumor-targeted drug delivery system, DOX@LA-pDAGEA/pPEGA-b-p(DMDEA-co-BADS), with reduction- and pH-dependent degradation and fluorescence imaging function displayed an enhanced anticancer effect.

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Sun, Shuguo, Beiping Li, Tao Yang, et al. "Preparation and Evaluation of Smart Nanocarrier Systems for Drug Delivery Using Magnetic Nanoparticle and Avidin-Iminobiotin System." Journal of Nanomaterials 2018 (August 28, 2018): 1–11. http://dx.doi.org/10.1155/2018/1627879.

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Therapeutic efficacy and the regulation of drug release can be improved by using selective targeting drug delivery systems. In this paper, we have demonstrated avidin-immobilized magnetic nanoparticles (AMNPs) as a novel targeted drug delivery system to deliver iminobiotinylated daunomycin (IDAU). TEM, XRD, VSM, and FTIR were employed for the physicochemical characterization of the drug-loaded MNPs. The binding of IDAU had little effect on sizes of AMNPs (~35 nm), but the stability and dispersibility of the nanoparticles were improved. The study also found that the loading capacity and efficie

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Zhang, Hai-jun, and Bao-An Chen. "Daunorubicin -TiO2 Nanocomposites As ‘smart' pH-Responsive Drug Delivery System,." Blood 118, no. 21 (2011): 3479. http://dx.doi.org/10.1182/blood.v118.21.3479.3479.

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Abstract Abstract 3479 Daunorubicin (DNR) with a broad spectrum of anti-tumor activity is limited due to the serious side-effects in the clinical application. The aim of this study was to explore the novel pH-responsive drug delivery system (DDS) based on titanium dioxide (TiO2) nanoparticles (Nps) for its potential roles to enable more intelligently controlled release, enhance chemotherapeutic efficiency, and reduce the side-effects of DNR. DNR was loaded onto the TiO2 Nps by forming (six-membered chelate) complexes with transition metal Ti to contract DNR-TiO2 nanocomposites as DDS. The enca

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González-Alvarez, Isabel, Verónica Vivancos, Carmen Coll, et al. "pH-Dependent Molecular Gate Mesoporous Microparticles for Biological Control of Giardia intestinalis." Pharmaceutics 13, no. 1 (2021): 94. http://dx.doi.org/10.3390/pharmaceutics13010094.

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Giardiasis is a parasitism produced by the protozoa Giardia intestinalis that lives as trophozoite in the small intestine (mainly in the duodenum) attached to the intestinal villus by means of billed discs. The first line treatment is metronidazole, a drug with high bioavailability, which is why to obtain therapeutic concentrations in duodenum, it is necessary to administer high doses of drug to patients with the consequent occurrence of side effects. It is necessary to developed new therapeutical approaches to achieve a local delivery of the drug. In this sense, we have developed gated mesopo

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Kim, Hyoung-Mi, Jae Hong Park, You Jin Choi, Jae-Min Oh, and Junghun Park. "Hyaluronic acid-coated gold nanoparticles as a controlled drug delivery system for poorly water-soluble drugs." RSC Advances 13, no. 8 (2023): 5529–37. http://dx.doi.org/10.1039/d2ra07276a.

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One-pot synthesis of gold nanoparticles coated with electron beam-irradiated hyaluronic acid was developed to achieve a pH-dependent sulfasalazine release system with high drug encapsulation efficiency.

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Alekya, Thota, Dudhipala Narendar, Donthi Mahipal, Narala Arjun, and Banala Nagaraj. "Design and Evaluation of Chronomodulated Drug Delivery of Tramadol Hydrochloride." Drug Research 68, no. 03 (2017): 174–80. http://dx.doi.org/10.1055/s-0043-119072.

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AbstractRheumatoid arthritis is an auto immune disease which requires chronotherapy as it occurs during early morning. Tramadol hydrochloride (TH) is an analgesic drug, used to treat rheumatoid arthritis. The aim of the present investigation was to develop chronomodulated drug delivery system of tramadol hydrochloride such that it releases the drug early in the morning, during which the symptoms of rheumatoid arthritis worsen. To develop chronomodulated drug delivery system of TH, initially core tablets of TH were prepared using three different supradisintegrants followed by coating with pH de

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Amatya, Shirisha, Jesse Green, Chi-Shuen Chu, et al. "Enabling Potent T Cell Delivery and Mitigating Key Off-Target Concerns of In Vivo CAR T Lentiviral Vectors with the Targeted Paramyxovirus Fusogen System." Blood 144, Supplement 1 (2024): 2047. https://doi.org/10.1182/blood-2024-211267.

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The promise of in vivo CAR T is to achieve or exceed the efficacy of ex vivo CAR Ts with a systemically delivered vector, enabling off-the-shelf CAR T therapy without lymphodepletion. Ex vivo approaches generally incorporate cell enrichment or selection steps so that only T cells are modified and delivered to the patient. Accordingly the burden for in vivo approaches will be to limit off-target (non-T cell) delivery and mitigate any consequent risk of CAR delivery to non-T cells. Different approaches have been used to engineer vectors that can mediate cell-specific delivery, including lentivir

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Abdeen, Rehab, and Nehal Salahuddin. "Modified Chitosan-Clay Nanocomposite as a Drug Delivery System Intercalation andIn VitroRelease of Ibuprofen." Journal of Chemistry 2013 (2013): 1–9. http://dx.doi.org/10.1155/2013/576370.

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The present paper focused on the intercalation of ibuprofen into sodium montmorillonite, chitosan, and chitosan montmorillonite nanocomposites as a sustained release drug carrier. The compounds were characterized by X-ray diffraction (XRD), infrared spectroscopy (IR), thermogravimetric analysis (TGA), and transmission electron microscopy (TEM). The basal spacing of montmorillonite increased from 9.6 Å to 19.6 Å indicating the intercalation of modified chitosan and ibuprofen between lamellar layers. UV spectroscopy was employed to monitor thein vitrodrug release processes in both pH 5.4 and 7.8

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Dubashynskaya, Natallia V., Valentina A. Petrova, Dmitry P. Romanov, and Yury A. Skorik. "pH-Sensitive Drug Delivery System Based on Chitin Nanowhiskers–Sodium Alginate Polyelectrolyte Complex." Materials 15, no. 17 (2022): 5860. http://dx.doi.org/10.3390/ma15175860.

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Polyelectrolyte complexes (PECs), based on partially deacetylated chitin nanowhiskers (CNWs) and anionic polysaccharides, are characterized by their variability of properties (particle size, ζ-potential, and pH-sensitivity) depending on the preparation conditions, thereby allowing the development of polymeric nanoplatforms with a sustained release profile for active pharmaceutical substances. This study is focused on the development of hydrogels based on PECs of CNWs and sodium alginate (ALG) for potential vaginal administration that provide controlled pH-dependent antibiotic release in an aci

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Marzouk, Maha AM, Amal AE Ammar, Zeinab AM Zalat, and Reem Ali Selim. "Impact of pH and Time-Dependent Polymers on Colon-Targeted Mebeverine Hydrochloride Drug Delivery System." Azhar International Journal of Pharmaceutical and Medical Sciences 5, no. 1 (2025): 297–310. https://doi.org/10.21608/aijpms.2024.247754.1239.

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39

Žid, Lukáš, Vladimír Zeleňák, Miroslav Almáši, et al. "Mesoporous Silica as a Drug Delivery System for Naproxen: Influence of Surface Functionalization." Molecules 25, no. 20 (2020): 4722. http://dx.doi.org/10.3390/molecules25204722.

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In this work we describe the relationship between surface modification of hexagonally ordered mesoporous silica SBA-15 and loading/release characteristics of nonsteroidal anti-inflammatory drug (NSAID) naproxen. Mesoporous silica (MPS) was modified with 3-aminopropyl, phenyl and cyclohexyl groups by grafting method. Naproxen was adsorbed into pores of the prepared MPS from ethanol solution using a solvent evaporation method. The release of the drug was performed in buffer medium at pH 2 and physiological solution at pH 7.4. Parent MPSs as well as naproxen loaded MPSs were characterized using p

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Khan, Muhammad Junaid, Wen-Can Huang, Muhammad Akhlaq, et al. "Design, Preparation, and Evaluation of Enteric Coating Formulation of HPMC and Eudragit L100 on Carboxylated Agarose Hydrogel by Using Drug Tartrazine." BioMed Research International 2022 (January 28, 2022): 1–6. http://dx.doi.org/10.1155/2022/1042253.

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Enteric-coated application on drug is used to prevent the drug from inactivation which are degraded by gastric enzyme. The present study is aimed at achieving controlled drug delivery in acidic medium of gastrointestinal tract (GIT) by enteric coating of hydroxy propyl methylcellulose (HPMC) and Eudragit L100 on carboxylated agarose hydrogel, creating a pH-dependent delivery system. Fourier-transformed infrared spectroscopy (FTIR) was for the detection of carboxylic group on agarose hydrogel, and scanning electron microscope (SEM) was used for the determination surface of prepared formulation.

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Kumar, Ritesh, Amrish Chandra, and Pawan Kumar Gautam. "Modified Approaches for Colon Specific Drug Delivery System: A Review." Indian Journal of Pharmaceutical and Biological Research 1, no. 03 (2013): 67–79. http://dx.doi.org/10.30750/ijpbr.1.3.12.

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The colon is a site where both local and systemic delivery of drugs can take place. Local delivery allows topical treatment of inflammatory bowel disease. However, treatment can be made effective if the drugs can be targeted directly into the colon, thereby reducing the systemic side effects. This review mainly describes the primary approaches for CDDS (Colon Specific Drug Delivery) namely prodrugs, pH and time dependent systems, and microbially triggered systems, which achieved limited success and had limitations as compared with newer CDDS namely pressure controlled colonic delivery capsules

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Gavade, Akshata S., Dheeraj S. Randive, Mangesh A. Bhutkar, Somnath D. Bhinge, Asha M. Jagtap, and Ganesh B. Vambhurkar. "PREPARATION AND EVALUATION OF CHITOSAN CAPSULE FOR COLON SPECIFIC DELIVERY OF CAPECITABINE." Indian Drugs 59, no. 05 (2022): 71–74. http://dx.doi.org/10.53879/id.59.05.12520.

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The prime objective of the present study was to develop enteric coated chitosan capsule containing capecitabine for targeting colorectal cancer cells. The study describes a new colonic drug delivery system utilizing capsule shells prepared from chitosan. Coating of drug filled chitosan capsule with pH dependent enteric polymer like HPMC K4M / Cellulose acetate phthalate provides it a special feature of releasing drug at colonic pH. The complex formation between HPMC K4M, cellulose acetate phthalate and chitosan capsule gives extended release of drug over longer period. The disintegration time

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Sandal, Nidhi, Gaurav Mittal, Aseem Bhatnagar, Dharam Pal Pathak, and Ajay Kumar Singh. "Preparation, Characterization, and In Vivo Pharmacoscintigraphy Evaluation of an Intestinal Release Delivery System of Prussian Blue for Decorporation of Cesium and Thallium." Journal of Drug Delivery 2017 (November 29, 2017): 1–9. http://dx.doi.org/10.1155/2017/4875784.

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Background. Prussian blue (PB, ferric hexacyanoferrate) is approved by US-FDA for internal decorporation of Cesium-137 (137Cs) and Thallium-201 (201Tl). Aim. Since PB is a costly drug, pH-dependent oral delivery system of PB was developed using calcium alginate matrix system. Methods. Alginate (Alg) beads containing PB were optimized by gelation of sodium alginate with calcium ions and effect of varying polymer concentration on encapsulation efficiency and release profile was investigated. Scanning electron microscopy (SEM) was carried out to study surface morphology. Adsorption efficacy of Al

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Al Hablawi, Moamin Fattah, and Iman Sabah Jaffar. "Formulation Variables Influencing the Development of Ketoconazole Gastroretentive Drug Delivery System." Al-Rafidain Journal of Medical Sciences ( ISSN 2789-3219 ) 7, no. 1(Special) (2024): S15–23. http://dx.doi.org/10.54133/ajms.v7i1(special).867.

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Background: Ketoconazole (KZ) is categorized as class II according to the Biopharmaceutics Classification System (BSC) classification, which shows a strong pH-dependent solubility where its solubility is enhanced under an acidic medium (pH below 3). This strong pH dependence results in unpredictable absorption and a wide range of bioavailabilities. Objective: To prolong the gastric residence time of KZ’s tablet to enhance KZ’s solubility and hence its bioavailability for better therapeutic activity. Methods: To prepare mucoadhesive tablets, we use both direct and wet granulation methods. We em

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Su, Hongying, Wen Zhang, Yayun Wu, et al. "Schiff base-containing dextran nanogel as pH-sensitive drug delivery system of doxorubicin: Synthesis and characterization." Journal of Biomaterials Applications 33, no. 2 (2018): 170–81. http://dx.doi.org/10.1177/0885328218783969.

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Stimuli-responsive hydrogels have been widely researched as carrier systems, due to their excellent biocompatibility and responsiveness to external physiologic environment factors. In this study, dextran-based nanogel with covalently conjugated doxorubicin (DOX) was developed via Schiff base formation using the inverse microemulsion technique. Since the Schiff base linkages are acid-sensitive, drug release profile of the DOX-loaded nanogel would be pH-dependent. In vitro drug release studies confirmed that DOX was released much faster under acidic condition (pH 2.0, 5.0) than that at pH 7.4. A

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Modasiya, Mohmadmoin K., A. K. Patel, V. M. Patel, and G. C. Patel. "In vitro and In vivo Characterization of Pectin Based In situ Gelling System of Famotidine." International Journal of Pharmaceutical Sciences and Nanotechnology 5, no. 4 (2013): 1885–94. http://dx.doi.org/10.37285/ijpsn.2012.5.4.9.

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In this study famotidine was used as a model drug to formulate and evaluate pH-induced in situ gelling system for oral sustained release drug delivery in stomach which has shorter biological half-life. To study the effect of independent variables 32 full factorial design was employed, concentration of pectin as pH dependant polymer and concentration of calcium chloride on dependent variables like viscosity, drug content, 50% and 80% drug release and similarity factor. It was found that both the concentration of pectin and concentration of calcium chloride had significant effect on viscosity, d

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A., Anil Kumar, Gopala Krishna Murthy T.E., and Prameela Rani A. "Influence of Kollidon SR on Ondansetron HCl pH Independent Drug Release from Hydroxypropyl Methyl Cellulose Matrix Tablets." Recent Trends in Pharmaceutical Sciences and Research 1, no. 2 (2019): 17–29. https://doi.org/10.5281/zenodo.3187545.

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<em>The Polymers are tools used in novel drug delivery system to modify the drug release of pharmaceutical dosage form. Ondansetron HCl is a weakly basic drug belongs to BCS class-II; it is showing distinct pH dependent solubility. The major intention of the current study was to develop a pH independent controlled released system for pH dependent poorly soluble Ondansetron HCl. The effect of combination of polymers on parameters like release pattern, release mechanism of the drug were studied. A 3<sup>2 </sup>full factorial design was used to study the effect of Kollidon SR on Ondansetron HCl

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Zhang, Jun, Yun Zeng, Min Su, et al. "Multifunctional Ferritin Nanoparticles as Theranostics for Imaging-Guided Tumor Phototherapy." Journal of Biomedical Nanotechnology 15, no. 7 (2019): 1546–55. http://dx.doi.org/10.1166/jbn.2019.2788.

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The pH-response reassemble ability of the ferritin nanocage (Fn) presents the unique and facile Fn-based drug delivery systems, which enable the drug loaded into the cage of TFn. In this study, we constructed a targeting CGKRK peptides modified Fn (TFn) by genetic engineering. The TFn possessed the targeting effect of the peptide CGKRK, and could efficiently target to the tumor angiogenic blood vessels and tumor cells. In addition, the TFn could be applied in drug delivery system due to its pH-dependent depolymerization and self-assembly properties. A new type metalla-aromatics complex of NIR-

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Navarro-Ruíz, Eva, Covadonga Álvarez-Álvarez, M. Ángeles Peña, Carlos Torrado-Salmerón, Zaid Dahma, and Paloma Marina de la Torre-Iglesias. "Multiparticulate Systems of Meloxicam for Colonic Administration in Cancer or Autoimmune Diseases." Pharmaceutics 14, no. 7 (2022): 1504. http://dx.doi.org/10.3390/pharmaceutics14071504.

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The aim of this research is the development of new colonic release systems of meloxicam (MLX) a non-steroidal anti-inflammatory drug (NSAIDs) with pH and time-dependent vehicles for cancer or autoimmune diseases. The colon has a higher pH than the rest of the gastrointestinal tract (GIT) and this can be used as a modified release strategy. Eudragit® polymers are the most widely used synthetic products in the design of colonic release formulations because they might offer mucoadhesiveness and pH-dependent release. Colonic delivery systems produced with pH-dependent and permeable polymers (FS-30

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S.Yousif, Hala, and Yehia I. Khalil. "In Situ Gelling Formulation of Naproxen for Oral Sustained Delivery System." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512) 18, no. 1 (2017): 13–20. http://dx.doi.org/10.31351/vol18iss1pp13-20.

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Naproxen is non-steroidal anti-inflammatory drug, which has antipyretic and anti-inflammatory effect. It is extensively bound to plasma albumin, and exhibits gastric toxicity, so it may be more efficient to deliver the drug in its sustained release dosage form and adequate blood level is achieved. Three liquid formulations with in situ gelling properties have been assessed for their potential for the oral sustained delivery of naproxen . The formulations were dilute solutions of: (a) pectin; (b) gellan gum and; (c) sodium alginate, all containing complexed calcium ion that form gels when these

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