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Journal articles on the topic 'PHA 543613'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Foucault-Fruchard, Laura, Aurélie Doméné, Guylene Page, et al. "Neuroprotective effect of the alpha 7 nicotinic receptor agonist PHA 543613 in an in vivo excitotoxic adult rat model." Neuroscience 356 (May 18, 2017): 52–63. https://doi.org/10.1016/j.neuroscience.2017.05.019.

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Abstract Neuroinflammation is a key component of the pathophysiology of neurodegenerative diseases. The link between nicotine intake and positive outcome has been established, suggesting a role played by nicotinic receptors (nAChRs), especially α7nAChRs. The objective of this study was to evaluate the potential dose effects of PHA 543613 on neuron survival and striatal microglial activation in a rat model of brain excitotoxicity. A preliminary study was performed in vitro to confirm PHA 543613 agonist properties on α7nAChRs. Rats were lesioned in the right striatum with quinolinic

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2

Zhou, Yudi, Cheng Hu, Chenlu Mao, Sha Li, Yaomei Cui та Yanning Qian. "Electroacupuncture Ameliorates Tibial Fracture-Induced Cognitive Dysfunction by Elevating α7nAChR Expression and Suppressing Mast Cell Degranulation in the Hippocampus of Rats". Evidence-Based Complementary and Alternative Medicine 2022 (12 квітня 2022): 1–11. http://dx.doi.org/10.1155/2022/3182220.

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Intracerebral neuroinflammation, closely related to brain mast cell (MC) activation, performs an integral function in the pathogenic process of postoperative cognitive dysfunction (POCD). In addition to regulating cognitive activities, the alpha-7-nicotinic acetylcholine receptor (α7nAChR) engages in the progression of cognitive deficiency. In this research, we aimed to investigate how electroacupuncture (EA) affects the cognitive function in rats after tibial fracture surgery to determine whether the underlying mechanism involves the inhibition of hippocampal MC degranulation via α7nAChR. A r

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3

Foucault-Fruchard, Laura, Claire Tronel, Sylvie Bodard, et al. "Alpha-7 nicotinic acetylcholine receptor agonist treatment in a rat model of Huntington's disease and involvement of heme oxygenase-1." Neural Regen Res. 13, no. 4 (2018): 737–41. https://doi.org/10.4103/1673-5374.230301.

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<strong>Abstract</strong> Neuroinflammation is a common element involved in the pathophysiology of neurodegenerative diseases. We recently reported that repeated alpha-7 nicotinic acetylcholine receptor (α7nAChR) activations by a potent agonist such as PHA 543613 in quinolinic acid-injured rats exhibited protective effects on neurons. To further investigate the underlying mechanism, we established rat models of early-stage Huntington's disease by injection of quinolinic acid into the right striatum and then intraperitoneally injected 12 mg/kg PHA 543613 or sterile water, twice a day

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4

Sérrière, Sophie, Aurélie Doméné, Johnny Vercouillie та ін. "Assessment of the protection of dopaminergic neurons by an α7 nicotinic receptor agonist, PHA 543613 using [18F]LBT-999 in a Parkinson's disease rat model." Frontiers in Medicine 2 (17 серпня 2015): 61. https://doi.org/10.3389/fmed.2015.00061.

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The inverse association between nicotine intake and Parkinson’s Disease (PD) is well established and suggests that this molecule could be neuroprotective through anti-inflammatory action mediated by nicotinic receptors, including the α7-subtype (α7R). The objective of this study was to evaluate the effects of an agonist of α7R, PHA 543613, on striatal dopaminergic neurodegeneration and neuroinflammation in a rat model of PD induced by 6-hydroxydopamine (6-OHDA) lesion. Adult male Wistar rats were lesioned in the right striatum and assigned to either the PHA group (n=7)

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5

Krafft, Paul R., Devin McBride, William B. Rolland, Tim Lekic, Jerry J. Flores та John H. Zhang. "α7 Nicotinic Acetylcholine Receptor Stimulation Attenuates Neuroinflammation through JAK2-STAT3 Activation in Murine Models of Intracerebral Hemorrhage". BioMed Research International 2017 (2017): 1–13. http://dx.doi.org/10.1155/2017/8134653.

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Accounting for high mortality and morbidity rates, intracerebral hemorrhage (ICH) remains one of the most detrimental stroke subtypes lacking a specific therapy. Neuroinflammation contributes to ICH-induced brain injury and is associated with unfavorable outcomes. This study aimed to evaluate whetherα7 nicotinic acetylcholine receptor (α7nAChR) stimulation ameliorates neuroinflammation after ICH. Male CD-1 mice and Sprague-Dawley were subjected to intracerebral injection of autologous blood or bacterial collagenase. ICH animals received eitherα7nAChR agonist PHA-543613 alone or combined withα7

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6

Krafft, Paul R., Basak Caner, Damon Klebe, William B. Rolland, Jiping Tang, and John H. Zhang. "PHA-543613 Preserves Blood–Brain Barrier Integrity After Intracerebral Hemorrhage in Mice." Stroke 44, no. 6 (2013): 1743–47. http://dx.doi.org/10.1161/strokeaha.111.000427.

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7

Han, Qiao-Qiao, Meng-Yan Deng, Hao Liu, Usman Ali, Xin-Yan Li та Yong-Xiang Wang. "Cynandione A and PHA-543613 inhibit inflammation and stimulate macrophageal IL-10 expression following α7 nAChR activation". Biochemical Pharmacology 190 (серпень 2021): 114600. http://dx.doi.org/10.1016/j.bcp.2021.114600.

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8

Sadigh-Eteghad, S., M. Talebi, J. Mahmoudi, S. Babri та D. Shanehbandi. "Selective activation of α7 nicotinic acetylcholine receptor by PHA-543613 improves Aβ25–35-mediated cognitive deficits in mice". Neuroscience 298 (липень 2015): 81–93. http://dx.doi.org/10.1016/j.neuroscience.2015.04.017.

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9

Foucault-Fruchard, Laura, Aurélie Doméné, Guylène Page, et al. "Neuroprotective effect of the alpha 7 nicotinic receptor agonist PHA 543613 in an in vivo excitotoxic adult rat model." Neuroscience 356 (July 2017): 52–63. http://dx.doi.org/10.1016/j.neuroscience.2017.05.019.

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10

Macpherson, Alexandrea, Noha Zoheir, Raja Azman Awang, et al. "The alpha 7 nicotinic receptor agonist PHA-543613 hydrochloride inhibits Porphyromonas gingivalis-induced expression of interleukin-8 by oral keratinocytes." Inflammation Research 63, no. 7 (2014): 557–68. http://dx.doi.org/10.1007/s00011-014-0725-5.

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11

Lv, Junyan, Yanhong Duan, Xinhe Wang, et al. "Alpha7 nicotinic acetylcholine receptor agonist PHA-543613 improves memory deficits in presenilin 1 and presenilin 2 conditional double knockout mice." Experimental Neurology 359 (January 2023): 114271. http://dx.doi.org/10.1016/j.expneurol.2022.114271.

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12

Bali, Zsolt K., Judit Inkeller, Roland Csurgyók, Nóra Bruszt, Hajnalka Horváth та István Hernádi. "Differential effects of α7 nicotinic receptor agonist PHA-543613 on spatial memory performance of rats in two distinct pharmacological dementia models". Behavioural Brain Research 278 (лютий 2015): 404–10. http://dx.doi.org/10.1016/j.bbr.2014.10.030.

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13

Ning, Houxu, Dong Cao, Haidong Wang, Bing Kang, Shiping Xie, and Yujing Meng. "Effects of haloperidol, olanzapine, ziprasidone, and PHA-543613 on spatial learning and memory in the Morris water maze test in naïve and MK-801-treated mice." Brain and Behavior 7, no. 8 (2017): e00764. http://dx.doi.org/10.1002/brb3.764.

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14

AlSharari, Shakir D., Deniz Bagdas, Hamid I. Akbarali та ін. "Sex Differences and Drug Dose Influence the Role of the α7 Nicotinic Acetylcholine Receptor in the Mouse Dextran Sodium Sulfate-Induced Colitis Model". Nicotine & Tobacco Research 19, № 4 (2016): 460–68. http://dx.doi.org/10.1093/ntr/ntw245.

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Abstract Introduction: α7 nicotinic acetylcholine receptors (nAChRs) play an important role in vagus nerve-based cholinergic anti-inflammatory effects. This study was designed to assess the role of α7 nAChRs in dextran sodium sulfate (DSS)-induced colitis in male and female mouse. We first compared disease activity and pathogenesis of colitis in α7 knockout and wild-type mice. We then evaluated the effect of several α7 direct and indirect agonists on the severity of disease in the DSS-induced colitis. Methods: Male and female adult mice were administered 2.5% DSS solution freely in the drinkin

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15

Athanasiadis, Vassilis, Theodoros Chatzimitakos, Eleni Bozinou, Konstantina Kotsou, Dimitrios Palaiogiannis, and Stavros I. Lalas. "Optimization of Extraction Parameters for Enhanced Recovery of Bioactive Compounds from Quince Peels Using Response Surface Methodology." Foods 12, no. 11 (2023): 2099. http://dx.doi.org/10.3390/foods12112099.

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Quinces are well known for their multiple health benefits, including antioxidant, hypoglycemic, antimicrobial, anti-inflammatory, anticarcinogenic, etc., properties. Despite the widespread utilization of various plant parts, the peel has been largely ignored in the industry. In this study, we explored the effects of different extraction parameters, such as temperature, time, and composition of the extraction solvent, and techniques such as ultrasound (US) and a pulsed electric field (PEF), either alone or in combination, and optimized these parameters using a response surface methodology (RSM)

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16

Bruszt, Nóra, Zsolt Kristóf Bali, Lili Veronika Nagy, Kornélia Bodó, Péter Engelmann, and István Hernádi. "Synergistic effects of memantine and alpha7 nicotinic acetylcholine receptor agonist PHA-543613 to improve memory of aged rats." International Journal of Neuropsychopharmacology, February 22, 2025. https://doi.org/10.1093/ijnp/pyaf014.

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Abstract Background Combination treatments based on pharmacological interactions at α7 nicotinic acetylcholine receptors (nAChR) are promising therapeutic approaches for neurocognitive disorders. Methods Here, we tested the cognitive efficacy of combinations of memantine with an α7 nAChR-selective agonist (PHA-543613) in naturally aged rats. Age-related changes in the expression of some key genes and proteins were also measured using quantitative PCR and ELISA. Results Aged rats showed marked cognitive decline in the novel object recognition test, and they also exhibited cholinergic changes su

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17

Bruszt, Nóra, Zsolt Kristóf Bali, Sai Ambika Tadepalli, Lili Veronika Nagy, and István Hernádi. "Potentiation of cognitive enhancer effects of Alzheimer’s disease medication memantine by alpha7 nicotinic acetylcholine receptor agonist PHA-543613 in the Morris water maze task." Psychopharmacology, August 13, 2021. http://dx.doi.org/10.1007/s00213-021-05942-4.

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Abstract Rationale There are controversial pieces of evidence whether combination therapies using memantine and cholinesterase inhibitors are beneficial over their monotreatments. However, results of preclinical studies are promising when memantine is combined with agonists and allosteric modulators of the alpha7 nicotinic acetylcholine receptor (nAChR). Objectives Here, we tested the hypothesis that cognitive enhancer effects of memantine can be potentiated through modulating alpha7 nAChRs in a scopolamine-induced amnesia model. Methods Monotreatments, as well as co-administrations of selecti

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18

Bali, Zsolt Kristóf, Lili Veronika Nagy, Nóra Bruszt, et al. "Increased brain cytokine level associated impairment of vigilance and memory in aged rats can be alleviated by alpha7 nicotinic acetylcholine receptor agonist treatment." GeroScience, November 23, 2023. http://dx.doi.org/10.1007/s11357-023-01019-6.

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AbstractAge-related neurocognitive disorders are common problems in developed societies. Aging not only affects memory processes, but may also disturb attention, vigilance, and other executive functions. In the present study, we aimed to investigate age-related cognitive deficits in rats and associated molecular alterations in the brain. We also aimed to test the effects of the alpha7 nicotinic acetylcholine receptor (nAChR) agonist PHA-543613 on memory as well as on the sustained attention and vigilance of aged rats. Short- and long-term spatial memories of the rats were tested using the Morr

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19

Sallam, Marwa Y., Sahar M. El‐Gowilly, Hanan M. El‐Gowelli та Mahmoud M. El‐Mas. "The α7/α4β2 nAChRs Alleviate The Hypotension And Altered Cardiac Sympathovagal Balance Evoked By Endotoxemia In Male Rats". FASEB Journal 31, S1 (2017). http://dx.doi.org/10.1096/fasebj.31.1_supplement.848.3.

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Nicotine favorably influences inflammatory conditions such as endotoxemia and ulcerative colitis through the activation of the cholinergic antiinflammatory pathway. In this communication, we hypothesized that α7 and/or α4β2 nicotinic acetylcholine receptors (nAChRs) protect against the cardiovascular and autonomic imbalances caused by endotoxemia. Experiments were performed in conscious male rats to assess the dose‐effect relationships for i.v. nicotine (25, 50, or 100 μg/kg), PHA‐543613 (selective α7 nAChR agonist; 0.2 or 2.0 mg/kg), or 5‐iodo‐A‐85380 (5IA, selective α4β2 nAChRs agonist; 0.01

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20

Stegemann, Agatha, Verena Raker, Adriana del Rey, Kerstin Steinbrink та Markus Böhm. "Expression of the α7 Nicotinic Acetylcholine Receptor is Critically Required for the Antifibrotic Effect of PHA-543613 on Skin Fibrosis". Neuroendocrinology, 11 червня 2021. http://dx.doi.org/10.1159/000517772.

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21

Abburi, Chandrika, Iboro C. Umana, Claire A. Daniele, et al. "Analgesic Effects Mediated by Alpha 7 Nicotinic Acetylcholine Receptors: A Potential Non‐Opioid Treatment for Pain." FASEB Journal 31, S1 (2017). http://dx.doi.org/10.1096/fasebj.31.1_supplement.lb578.

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Nicotinic acetylcholine receptors (nAChRs) are expressed abundantly throughout the nervous system. A wide variety of neurobehavioral processes involve nAChRs, including analgesic effects in chronic pain models. However, nAChR subunit composition and cellular mechanisms underlying nAChR mediated analgesia are not well understood. Ventrolateral periaqueductal gray (vlPAG) is an important target for analgesic drugs in the descending pain modulatory pathway. Thus, we investigated the nAChRs in vlPAG and tested their antinociceptive effects in an animal model of pain.Adult male Sprague Dawley rats

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22

Sérrière, Sophie, Aurélie Doméné, Johnny Vercouillie та ін. "Assessment of the Protection of Dopaminergic Neurons by an α7 Nicotinic Receptor Agonist, PHA 543613 Using [18F]LBT-999 in a Parkinson’s Disease Rat Model". Frontiers in Medicine 2 (2 вересня 2015). http://dx.doi.org/10.3389/fmed.2015.00061.

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23

Malla, Subas, Kevin M. Crosby, and Edgar Correa. "Optimizing seedling screening method for anthracnose resistance in watermelon." Plant Health Progress, July 16, 2021. http://dx.doi.org/10.1094/php-04-21-0077-rs.

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Among three races of Colletotrichum orbiculare, causes of anthracnose of cucurbits, screening for race 2 resistance was studied under greenhouse conditions at various inoculum concentrations and rated plants on different days post inoculation (DPI). The objectives of this study were optimizing inoculum concentration and phenotyping DPI for seedling resistance. Five inoculum concentrations were compared (2.5 x 104, 5 x 104, 1 x 105, 2.5 x 105, and 5 x 105 conidial spore ml-1). Four watermelon genotypes, ‘Black Diamond’, ‘Charleston Gray 133’, PI 543210, PI 189225, and two cucumber genotypes, ‘M

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