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Dissertations / Theses on the topic 'Phae display'

Author: Grafiati
Published: 4 June 2021
Last updated: 2 February 2022

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1

De, Leon Ellen Jane Biotechnology &amp Biomolecular Sciences Faculty of Science UNSW. "Engineering antibodies against complex platelet antigens using phage display technology." Awarded by:University of New South Wales, 2007. http://handle.unsw.edu.au/1959.4/37009.

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Platelets are small anucleate cell fragments found in blood whose physiological role is important in maintaining haemostasis. In vivo, platelet surface glycoproteins mediate the mechanistic roles of platelets, and polymorphic changes to these glycoproteins have been observed to have significant effects on the platelet cellular function and such changes may include over-expression, under-expression and antigenicity of the protein. Human platelet antigens (HPA) are a result of polymorphic differences in platelet surface glycoproteins which have been found to be variably expressed in the populati
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2

Nangola, Sawitree. "The interference of human immunodeficiency virus assembly and maturation by ankyrin repeat proteins." Thesis, Paris 11, 2011. http://www.theses.fr/2011PA112044.

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Le but de ce travail est de découvrir des nouvelles protéines suceptibles d'interférer avec le cycle vital du virus HIV. De par leur repliement, les protéines à motifs ankyrines peuvent constituer une ossature protéique trés bien adaptée à cet objectif. Plusieurs interacteurs spécifiques de la protéine MA-CA du HIV ont été sélectionnées par exposition sur phage à partir d'une bibliothèque de variants d'ankyrines. Trois protéines isolées ont été produites à partir de clones ayant une forte activité de liaison. Le meilleur interacteur protéique (1D4) interagit avec un épitope situié sur le domai
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3

Rosander, Anna. "Novel applications of shotgun phage display /." Uppsala : Dept. of Microbiology, Swedish Univ. of Agricultural Sciences, 2004. http://epsilon.slu.se/a450.pdf.

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4

Holmes, David Ian Roderick. "Phage display of chymotrypsin inhibitor II." Thesis, Imperial College London, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.283414.

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5

Smith, Mathew Wayne. "Phage display and experimental brain therapeutics." Thesis, Cardiff University, 2009. http://orca.cf.ac.uk/55853/.

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Phage display, a powerful polypeptide display technology, affords the rapid identification of peptides and proteins that interact with a target of interest The aims of the project were the phage display identification of peptides that interact with a druggable target in a brain disorder (glioblastoma multiforme) and the identification of peptides that serve as targeting vectors for brain delivery. Validation studies were undertaken to qualify the use of a cyclic 7-mer peptide phage library against targets including streptavidin and paracetamol chosen as examples of a large complex and small si
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Drever, Matthew. "Generating microcystin antibodies by phage display." Thesis, University of Aberdeen, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.445137.

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A naïve human antibody fragment phage display library was screened against conjugated microcystin-LR (MCLR).  Phage antibodies were eluted with free MCLR to promote the isolation of free antigen binders.  Isolated antibody fragments were cloned into a soluble expression vector and single-chain antibody (scAb) expressed in a bacterial host.  All scAbs bound free antigen in an indirect competition ELISA and levels of sensitivity were determined.  The most responsive clone 3A8 had an 800-fold increase in sensitivity to MCLR than previously documented scAbs and was able to detect levels below guid
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7

Meyer, Scott C. "Non-Covalent Selection Methodologies Utilizing Phage Display." Diss., The University of Arizona, 2007. http://hdl.handle.net/10150/194059.

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In nature, non-covalent interactions are as important and dynamic as they are elusive. As such, the study of non-covalent interactions both in vivo and in vitro has proven to be challenging. Given the potential benefits of elucidating protein-protein, ligand-receptor, and other biologically relevant interactions, the development of methodologies for the study of non-covalent interactions is an attractive goal.Biologically encoded protein and peptide libraries that connect the genotypic information with the expressed phenotype have emerged in recent years as powerful methods for studying non
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8

Bonnert, Timothy Peter. "Strategies for making antibodies by phage display." Thesis, University of Cambridge, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294402.

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9

Ching, Ana Tung Ching. "Identificação de adesinas bacterianas por phage display." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/87/87131/tde-05022013-084410/.

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A leptospirose é uma zoonose de importância mundial causada por bactérias do gênero Leptospira. No Brasil, a maioria dos casos é causada por L. interrogans sorovar Copenhageni. O objetivo destre trabalho foi identificar adesinas de leptospira pela técnica de Phage display. Bibliotecas com fragmentos genômicos resultaram na idendificação de ligantes de leptospira com afinidade por tecidos de hamster. Uma varredura dessas bibliotecas contra heparan sulfato proteoglicano (HSPG) identificou como ligantes as proteínas LigA e LigB. Proteínas recombinantes foram produzidas e submetidas à ligação às c
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10

Gomes, Margarida. "Développement de bibliothèques de protéines artificielles permettant la création d’outils de reconnaissance moléculaire innovants." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS030.

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Le travail de thèse présente une approche innovante pour la construction d’une bibliothèque de protéines basées sur l’ossature protéique. L’objectif est de générer une source de biodiversité artificielle permettant la création de nouvelles capacités d’interaction avec des cibles d’intérêts. Une banque, basée sur une ossature protéique bactérienne avait déjà été construite dans l’équipe, mais elle nécessitait d’être optimisée. L’étape initiale a été d’explorer les raisons de l’instabilité des protéines de la banque de première génération, ceci par des approches d’étude de la structure in silico
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11

Wright, Michael John. "Anti-tumour chelating recombinant antibodies by phage display." Thesis, Imperial College London, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.405798.

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12

Madeja, Benjamin [Verfasser]. "Phage Display Screening for Cement Systems / Benjamin Madeja." Konstanz : KOPS Universität Konstanz, 2018. http://d-nb.info/1202440800/34.

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13

Dueñas, Marta. "Phage display and bacterial expression of antibody fragments." Lund : Dept. of Immunotechnology, Lund University, 1995. http://catalog.hathitrust.org/api/volumes/oclc/38164515.html.

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14

Gomes, Carlos Henrique Rodrigues. "Construção de uma bibilioteca de anticorpos ScFv dirigidos contra o fator de crescimento vascular (VEGF)." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-09082013-093807/.

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Angiogênese é a formação de novos vasos sanguíneos a partir de vasos já existentes e é importante em processos fisiológicos, que em adultos é restrita ao reparo tecidual e ao ciclo reprodutivo feminino. Entretanto, doenças, como câncer ou retinopatias, induzem a formação da angiogênese patológica, necessária para a progressão destas patologias. Anticorpos monoclonais constituem uma das classes de biofármacos que mais cresce e com impacto importante nas doenças dependentes de angiogênese. Entre as diversas metodologias para a identificação de anticorpos monoclonais contra alvos terapêuticos, es
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15

Mathonet, Pascale. "Création d'un site allostérique dans la beta-lactamase TEM-1 par évolution dirigée." Université catholique de Louvain, 2004. http://edoc.bib.ucl.ac.be:81/ETD-db/collection/available/BelnUcetd-04282004-121335/.

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L'objectif de ce travail est d'introduire, par ingénierie génétique, un site allostérique dans une enzyme pour moduler son activité catalytique par la liaison d'un ligand choisi. Ces enzymes pourraient servir de senseurs moléculaires pour la détection, voire le dosage du ligand. Nous avons décidé de créer ces sites allostériques dans la beta-lactamase TEM-1 d'E. coli, une enzyme dégradant les antibiotiques de type pénicilline, en réalisant l'ingénierie de trois boucles de l'enzyme. Celles-ci sont proches l'une de l'autre dans l'espace et pourraient servir d'épitope discontinu pour la reconnais
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Murarasu, Thomas. "The Shiga Toxin B-Subunit : a Promising Scaffold for the Targeting of Tumor Specific Glycosphingolipids." Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS512.

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Le cancer représente la second cause de décès au monde. Le développement de traitements innovants contre le cancer repose aujourd’hui sur l’identification de biomarqueurs des tumeurs et le développement de produits thérapeutiques capables de reconnaitre ces marqueurs de façon spécifique. Ces produits thérapeutiques de nouvelles générations ont le potentiel d’éliminer spécifiquement les cellules tumorales et donc de réduire les effets secondaires des traitements ainsi que les risques de rechute. Malheureusement, un certain nombre de patients ne peuvent bénéficier de ces traitements, du fait de
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17

Wilson, Daniel Ross. "Multivalent pIII phage display libraries, selected issues and applications." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq25187.pdf.

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18

Yeoh, Tsin Inn Louisa. "Single-chain antibody engineering against mecoprop using phage display." Thesis, Imperial College London, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.429362.

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Bell, Matthew John. "Phage display of a cDNA library from Arabidopsis thaliana." Thesis, Coventry University, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.393652.

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20

Chen, Kuan Ming. "Submillisecond-response blue phase liquid crystals for display applications." Doctoral diss., University of Central Florida, 2012. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/5158.

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With exploding growth of information exchanges between people, display has become indispensable in our daily lives. After decades of intensive research and development in materials and devices, and massive investment in manufacturing technologies, liquid crystal display (LCD) has overcome various obstacles and achieved the performance we need, such as wide viewing angle, high contrast ratio, and high resolution, etc. These excellent performances make LCD prevailed in every perspective. Recently, with the demands of energy conservation, a greener LCD with lower power consumption is desired. In
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21

Kelly, Michael A. "Developing Peptide Probes for Membrane Lipids via Phage Display:." Thesis, Boston College, 2020. http://hdl.handle.net/2345/bc-ir:108919.

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Thesis advisor: Jianmin Gao<br>Lipid reporters are key signaling molecules in a number of biological processes ranging from apoptosis in mammalian cells to novel resistance mechanisms in pathogenic bacteria. Developing probes to target these lipids is a worthy endeavor, especially when better reporters could mean lives saved. This is particularly true considering new antibiotic resistant pathogens emerge every year with evolving lipid compositions. To combat these pathogens and prevent a potential global pandemic, it is imperative to continue the development of novel and innovative probes/drug
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22

Filipovic, Nedim. "Phage display to identify functional resistance mutations to Rigosertib." Scholarship @ Claremont, 2017. http://scholarship.claremont.edu/cmc_theses/1475.

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In vitro protein selection has had major impacts in the field of protein engineering. Traditional screens assay individual proteins for specific function. Selection, however, analyzes a pool of mutants and yields the best variants. Phage display, a successful selection technique, also provides a reliable link between variant phenotype and genotype. It can also be coupled with high throughput sequencing to map protein mutations; potentially highlighting vital mutations in variants. We propose to apply this technique to cancer therapy. RAF, a serine/threonine kinase, is critical for cell regulat
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23

Johansson, Louise. "Proteomic peptide phage display of syntenin-1 and scribble." Thesis, Uppsala universitet, Institutionen för kemi - BMC, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-255887.

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24

Scott, Nathan. "Anti-tetanus toxin chelating recombinant antibodies by phage display." Thesis, Imperial College London, 2008. http://hdl.handle.net/10044/1/4638.

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Chelating Recombinant Antibodies (CRAbs) are a form of high affinity tandem single chain antibody (scFv) with two component scFvs which target non‐overlapping epitopes on the same antigen molecule. The optimised inter‐scFv linker allows simultaneous engagement of the scFvs resulting in a synergistic improvement in affinity. High affinity is a desirable characteristic in therapeutic antibodies since it strongly correlates with improved potency. Building upon previous work, this thesis describes the development of a phage‐display based approach toward isolating CRAbs with both the optimal scFv p
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25

Tomini, Khaled. "The isolation of novel leptin variants using phage display." Thesis, University of Sheffield, 2015. http://etheses.whiterose.ac.uk/12363/.

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Leptin is a polypeptide hormone with important roles in a number of physiological pathways. Most significantly leptin acts a major regulator of energy metabolism and defects in hormone signalling form the basis of a number of human conditions, including morbid obesity, cardiovascular disease, and diabetes. Leptin is also an important immunomodulatory hormone and may contribute to a range of inflammatory diseases. For these reasons there is significant interest in the development of novel forms of leptin as possible therapeutic agents. Research into therapeutic applications of leptin has focuse
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Magalhães, Leila da Silva. "Importância do domínio extracelular do receptor tirosina quinase Tie1 na angiogênese." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-11042017-081713/.

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Tie1 é um receptor tirosina quinase expresso em células endoteliais importante em angiogênese, formação de vasos sanguíneos a partir de vasos pré-existentes. Este receptor pertence a uma família pequena composta por apenas dois membros (Tie1 e Tie2) para os quais angiopoietinas foram identificadas como ligantes de Tie2. No entanto, Tie1 continua a ser um receptor órfão, sem ligantes identificados até o momento. Sendo assim, é difícil compreender completamente as propriedades biológicas de Tie1 e seus mecanismos moleculares em angiogênese sem um ligante identificado. Entretanto, como sugerido a
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27

Lima, Swiany Silveira. "Identificação de adesinas de Leptospira interrogans por shotgun phage display." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-02052013-095417/.

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Em Leptospira interrogans algumas proteínas com capacidade de ligação aos componentes de matriz extracelular foram identificadas e, em sua maioria, são fatores de virulência. Phage display é considerada uma técnica poderosa na identificação de novos ligantes, inclusive de moléculas adesinas, importantes no primeiro estágio de infecção do hospedeiro. A técnica de shotgun phage display foi utilizada visando à obtenção de ligantes à células de mamíferos. Quatro bibliotecas, por inserção de fragmentos aleatórios obtidos por sonicação do DNA de L. interrogans nos fagomídeos pG8SAET (BBT1 e BBT2) e
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28

Kioshima, Érika Seki [UNIFESP]. "Caracterização de marcadores de virulência em Paracoccidioides brasiliensis." Universidade Federal de São Paulo (UNIFESP), 2009. http://repositorio.unifesp.br/handle/11600/9171.

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Made available in DSpace on 2015-07-22T20:49:41Z (GMT). No. of bitstreams: 0 Previous issue date: 2009-06-24<br>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>A paracoccidioidomicose (PCM) é uma doença sistêmica de caráter granulomatoso, prevalente na América do Sul, causada pelo fungo termodimórfico Paracoccidioides brasiliensis. O fungo apresenta estrutura complexa de proteínas e glicoproteínas e dentre esses componentes, alguns estão envolvidos na patogenicidade da doença. A recuperação da virulência
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29

Minter, Ralph. "Development of antibody technology to identify natural killer cell surface antigens in Xenopus laevis." Thesis, Durham University, 1999. http://etheses.dur.ac.uk/4598/.

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Natural killer (NK)-like lymphocytes have recently been identified in thymectomised (Tx) Xenopus which are capable of spontaneous cytotoxicity towards the MHC- deficient, allogeneic thymus tumour cell line B(_3)B(_7). This Thesis describes attempts to raise antibodies to Xenopus NK cell surface antigens by phage display and hybridoma technology. The phage display technique was optimised for raising antibodies to novel, cellular antigens in a trial run using the Xenopus thymus tumour cell line B(_3)B(_7). Having isolated a phage antibody which was shown by flow cytometry to bind B(_3)B(_7) cell
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Kwiatkowski, Eric. "Towards a novel group B meningococcal vaccine : peptide mimicry of capsular polysaccharide epitopes." Thesis, University of Nottingham, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.324533.

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31

Li, Yan. "High-efficiency Blue Phase Liquid Crystal Displays." Doctoral diss., University of Central Florida, 2012. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/5399.

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Blue phase liquid crystals (BPLCs) have a delicate lattice structure existing between chiral nematic and isotropic phases, with a stable temperature range of about 2 K. But due to short coherent length, these self-assembled nano-structured BPLCs have a fast response time. In the past three decades, the application of BPLC has been rather limited because of its narrow temperature range. In 2002, Kikuchi et al. developed a polymer stabilization method to extend the blue-phase temperature range to more than 60 K. This opens a new gateway for display and photonic applications. In this dissertatio
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Rao, Linghui. "Low Voltage Blue Phase Liquid Crystal Displays." Doctoral diss., University of Central Florida, 2012. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/5448.

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From cell phones, laptops, desktops, TVs, to projectors, high reliability LCDs have become indispensable in our daily life. Tremendous progress in liquid crystal displays (LCDs) has been made after decades of extensive research and development in materials, device configurations and manufacturing technology. Nowadays, the most critical issue on viewing angle has been solved using multidomain structures and optical film compensation. Slow response time has been improved to 2-5 ms with low viscosity LC material, overdrive and undershoot voltage, and thin cell gap approach. Moving image blur ha
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Abidi-Azzouz, Naïma. "Élaboration d'Intrabodies ciblant l'organisation conformationnelle du complexe de reverse transcription de VIH-1." Thesis, Montpellier 2, 2013. http://www.theses.fr/2013MON20050/document.

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Les traitements actuels dirigés contre le VIH ne sont que partiellement efficaces en raison de l'apparition de mutations qui confèrent au virus une grande capacité de résistance aux antirétroviraux existants. Un moyen d'améliorer la lutte contre le virus consiste par conséquent à trouver de nouvelles stratégies d'inhibition. Le complexe de reverse transcription est une des principales cibles pour le développement de traitement anti-SIDA, il catalyse une étape obligatoire du cycle de réplication du virus. Cependant, l'ensemble des inhibiteurs de la transcriptase inverse sont limités par l'appar
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Gadzekpo, Isaac Kwabena. "Selection of Phage Displaying Peptides Specific for Staphylococcus Aureus." Youngstown State University / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ysu1619516455248529.

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Glökler, Jörn Felix. "Identifikation und Charakterisierung von Metallchelat-bindenden Peptiden mittels Phage-Display." [S.l. : s.n.], 2000. http://deposit.ddb.de/cgi-bin/dokserv?idn=958911894.

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Zwick, Michael Bruce. "Applications and characterization of peptides derived from phage-display libraries." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0028/NQ51943.pdf.

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Starzomski, Mark Stephen. "Characterization and applications of the phase-modulating liquid crystal display." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape8/PQDD_0016/MQ48289.pdf.

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Weber, Patric. "Display of trypanosomal antigens on the surface of filamentous phage /." [S.l.] : [s.n.], 1994. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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Draghici, Alex-Bogdan. "Sind Antikörper gegen fusionsrelevante HIV-Fragmente mittels Phage Display generierbar?" Göttingen Sierke, 2008. http://d-nb.info/992286891/04.

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Sang, Sheila J. "The Use of Phage Display to Identify Specific Peptide Ligands." Youngstown State University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ysu1409923241.

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Joulie, Michaël. "Recherche de nouvelles protéines humaines se liant à l'ADN méthylé." Thesis, Paris 11, 2011. http://www.theses.fr/2011PA112157/document.

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L'épigénétique est un composant essentiel du fonctionnement des génomes eucaryotes. Les divers phénomènes épigénétiques modifient l’état chromatinien et participent à la plasticité du génome, mais aussi au maintien de son identité fonctionnelle à travers les générations cellulaires. Parmi ces processus, la méthylation de l’ADN joue un rôle fondamental dans la régulation de l’expression des gènes.Chez les mammifères, la méthylation de l'ADN est associée à la répression transcriptionnelle, et elle remplit au moins trois fonctions essentielles. Premièrement, elle permet de réprimer les séquences
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Even, Klervi. "Développement d' outils innovants pour le diagnostic et la découverte de cibles dans le cancer du sein." Thesis, Aix-Marseille, 2012. http://www.theses.fr/2012AIXM4019/document.

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Au cours de sa vie, 1 femme sur 9 sera atteinte du cancer du sein, 1 sur 27 sera emportée par cette maladie et 10 à 15 % des patientes développeront des métastases dans les trois années suivant le diagnostic. Le diagnostic précis et personnalisé du cancer du sein ainsi que l'évaluation de son potentiel métastatique est donc un enjeu majeur. Une analyse plus précise des caractéristiques moléculaires d'une tumeur primaire devrait conduire à une médecine personnalisée, un traitement et un suivi plus efficace. La détection de biomarqueurs sériques serait un moyen de diagnostiquer un cancer métasta
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Ferreira, Fabiana Lauretti. "Identificação e avaliação de novas adesinas em Leptospira interrogans por shotgun phage display." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-15122015-091903/.

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Leptospirose é uma doença infecciosa emergente cujos agentes etiológicos são espécies patogênicas do gênero Leptospira. Leptospiras patogênicas possuem inúmeros genes específicos codificando proteínas com funções desconhecidas, sugerindo que as leptospiras apresentam fatores de virulência únicos. Adesinas bacterianas são importantes fatores de virulência e, assim, a identificação de adesinas conservadas em espécies patogênicas de Leptospira pela construção de bibliotecas genômicas expostas na superfície de bacteriófagos (shotgun phage display), seguida por seleção em células e/ou componentes d
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Revilliod, Claude. "Photo-thermochimie : mécanisme et cinétique d'une réaction de méthanation en phase gaz-solide /." [S.l.] : [s.n.], 1991. http://library.epfl.ch/theses/?display=detail&nr=956.

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Stoiber, Johannes. "Hysteresis effects during martensitic phase transformations in Cu-Zn-Al shape memory alloys /." [S.l.] : [s.n.], 1993. http://library.epfl.ch/theses/?display=detail&nr=1115.

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Hald, Rikke. "Generation and characterisation of a naive human antibody phage display library : a resource for clinically relevant reagents /." Cph. : Department of Pharmacology, The Danish University of Pharmaceutical Sciences, 2004. http://www.dfh.dk/phd/defences/rikkehald.htm.

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Moutel, Sandrine. "Sélection et amélioration d'anticorps recombinants, applications à la recherche fondamentale et à l'immunothérapie." Paris 6, 2009. http://www.theses.fr/2009PA066520.

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Les anticorps (Ac) monoclonaux sont maintenant des outils couramment utilisés aussi bien pour le diagnostic que pour la recherche fondamentale dans l’étude ou la purification des protéines. Avec le développement de l’ingénierie génétique des Ac, il a été possible de cloner des régions variables d’anticorps humains et d’obtenir des banques de grande diversité. Au laboratoire, un investissement particulier a été fait ces dernières années pour adapter les méthodes de sélection d'anticorps recombinants (rAc) aux questions de la biologie cellulaire. La technique du phage display que nous utilisons
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48

Coulon, Stéphane. "Amélioration de la Spécificité et de l'Affinité de Fragments d'Anticorps Anti-stéroïde par Mutagenèse et Phage-display." Paris 7, 2001. http://www.theses.fr/2001PA077130.

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49

Castel, Guillaume. "Recherche de peptides à activités antivirales ciblant le complexe de réplication/transcription des Mononegavirales." Paris 6, 2009. http://www.theses.fr/2009PA066021.

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Le complexe RNP assure la transcription/réplication du génome des Mononegavirales. Afin d’identifier des peptides inhibiteurs ce complexe a été ciblé par 2 approches « cognitive » ou « aléatoire». Approche « cognitive » : L’extrémité Nt de la protéine P est capitale dans ce complexe interagissant avec les protéines N et L. Le potentiel antiviral de 3 peptides (P42, P57, P60) couvrant les 42, 57 et 60 aa Nt de P a été évalué. P42 et P60 interagissent avec L et N et la transfection de leur ADNc permet d’inhiber fortement un miniréplicon ou une infection rabiques. Ils ont été synthétisé et leur e
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50

Chahboun, Siham. "Comparaison des régions variables des anticorps de macaques (Macaca fascicularis) et de l' Homme et leurs utilisation pour la neutralisation des toxines botuliques A et B." Thesis, Grenoble, 2013. http://www.theses.fr/2013GRENV022.

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Notre laboratoire a développé une stratégie d'isolement de fragments d'anticorps recombinants à partir de primates non humains (Macaca fascicularis) immunisés, en utilisant la technologie des phages. Dans le cadre de cette thèse, une comparaison des séquences d'anticorps de macaques (Macaca Mulatta) et d'anticorps humains a toutefois montré que les anticorps des deux espèces présentent des différences qui rendent souhaitable une étape d'humanisation des anticorps de macaques. Cette stratégie a été utilisée dans le cadre du projet Européen AntiBotABE (www.antibotabe.com) et l'étape de criblage
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