Relevant bibliographies by topics / Pharmaceutical Adsorption

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Pharmaceutical Adsorption'

Author: Grafiati
Published: 4 June 2021
Last updated: 16 February 2022

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Journal articles on the topic "Pharmaceutical Adsorption"

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Kryuchkova, Marina, Svetlana Batasheva, Farida Akhatova, Vasily Babaev, Daina Buzyurova, Anna Vikulina, Dmitry Volodkin, Rawil Fakhrullin, and Elvira Rozhina. "Pharmaceuticals Removal by Adsorption with Montmorillonite Nanoclay." International Journal of Molecular Sciences 22, no. 18 (September 7, 2021): 9670. http://dx.doi.org/10.3390/ijms22189670.

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The problem of purifying domestic and hospital wastewater from pharmaceutical compounds is becoming more and more urgent every year, because of the continuous accumulation of chemical pollutants in the environment and the limited availability of freshwater resources. Clay adsorbents have been repeatedly proposed as adsorbents for treatment purposes, but natural clays are hydrophilic and can be inefficient for catching hydrophobic pharmaceuticals. In this paper, a comparison of adsorption properties of pristine montmorillonite (MMT) and montmorillonite modified with stearyl trimethyl ammonium (hydrophobic MMT-STA) towards carbamazepine, ibuprofen, and paracetamol pharmaceuticals was performed. The efficiency of adsorption was investigated under varying solution pH, temperature, contact time, initial concentration of pharmaceuticals, and adsorbate/adsorbent mass ratio. MMT-STA was better than pristine MMT at removing all the pharmaceuticals studied. The adsorption capacity of hydrophobic montmorillonite to pharmaceuticals decreased in the following order: carbamazepine (97%) > ibuprofen (95%) > paracetamol (63–67%). Adsorption isotherms were best described by Freundlich model. Within the pharmaceutical concentration range of 10–50 µg/mL, the most optimal mass ratio of adsorbates to adsorbents was 1:300, pH 6, and a temperature of 25 °C. Thus, MMT-STA could be used as an efficient adsorbent for deconta×ating water of carbamazepine, ibuprofen, and paracetamol.
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de Ridder, D. J., A. R. D. Verliefde, S. G. J. Heijman, J. Q. J. C. Verberk, L. C. Rietveld, L. T. J. van der Aa, G. L. Amy, and J. C. van Dijk. "Influence of natural organic matter on equilibrium adsorption of neutral and charged pharmaceuticals onto activated carbon." Water Science and Technology 63, no. 3 (February 1, 2011): 416–23. http://dx.doi.org/10.2166/wst.2011.237.

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Natural organic matter (NOM) can influence pharmaceutical adsorption onto granular activated carbon (GAC) by direct adsorption competition and pore blocking. However, in the literature there is limited information on which of these mechanisms is more important and how this is related to NOM and pharmaceutical properties. Adsorption batch experiments were carried out in ultrapure, waste- and surface water and fresh and NOM preloaded GAC was used. Twenty-one pharmaceuticals were selected with varying hydrophobicity and with neutral, negative or positive charge. The influence of NOM competition and pore blocking could not be separated. However, while reduction in surface area was similar for both preloaded GACs, up to 50% lower pharmaceutical removal was observed on wastewater preloaded GAC. This was attributed to higher hydrophobicity of wastewater NOM, indicating that NOM competition may influence pharmaceutical removal more than pore blocking. Preloaded GAC was negatively charged, which influenced removal of charged pharmaceuticals significantly. At a GAC dose of 6.7 mg/L, negatively charged pharmaceuticals were removed for 0–58%, while removal of positively charged pharmaceuticals was between 32–98%. Charge effects were more pronounced in ultrapure water, as it contained no ions to shield the surface charge. Solutes with higher log D could compete better with NOM, resulting in higher removal.
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Mansouri, Fatma, Khawla Chouchene, Nicolas Roche, and Mohamed Ksibi. "Removal of Pharmaceuticals from Water by Adsorption and Advanced Oxidation Processes: State of the Art and Trends." Applied Sciences 11, no. 14 (July 20, 2021): 6659. http://dx.doi.org/10.3390/app11146659.

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Pharmaceutical products have become a necessary part of life. Several studies have demonstrated that indirect exposure of humans to pharmaceuticals through the water could cause negative effects. Raw sewage and wastewater effluents are the major sources of pharmaceuticals found in surface waters and drinking water. Therefore, it is important to consider and characterize the efficiency of pharmaceutical removal during wastewater and drinking-water treatment processes. Various treatment options have been investigated for the removal/reduction of drugs (e.g., antibiotics, NSAIDs, analgesics) using conventional or biological treatments, such as activated sludge processes or bio-filtration, respectively. The efficiency of these processes ranges from 20–90%. Comparatively, advanced wastewater treatment processes, such as reverse osmosis, ozonation and advanced oxidation technologies, can achieve higher removal rates for drugs. Pharmaceuticals and their metabolites undergo natural attenuation by adsorption and solar oxidation. Therefore, pharmaceuticals in water sources even at trace concentrations would have undergone removal through biological processes and, if applicable, combined adsorption and photocatalytic degradation wastewater treatment processes. This review provides an overview of the conventional and advanced technologies for the removal of pharmaceutical compounds from water sources. It also sheds light on the key points behind adsorption and photocatalysis.
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Ferchichi, Maroua, and Hatem Dhaouadi. "Sorption of paracetamol onto biomaterials." Water Science and Technology 74, no. 1 (April 29, 2016): 287–94. http://dx.doi.org/10.2166/wst.2016.218.

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Pharmaceutical residues released into the environment are posing more and more public health problems. It is worthwhile to study the retention of pharmaceuticals residues by adsorption on solid supports. Batch sorption experiments are intended to identify the adsorption isotherms of the pharmaceutically active ingredient on the biomaterials. The results obtained in this study have shown that the retention possibilities of these compounds by bio-adsorbents (clay and sand) are not significant. The negligible sorption for these media is explained by the low hydrophobicity of paracetamol (Log Kow = 0.46). The retention of paracetamol on the dehydrated sewage sludge and on Posidonia oceanica showed a relatively significant adsorption with a maximal quantity of 0.956 mg g−1 and 1.638 mg g−1 for the dehydrate sludge and P. oceanica, respectively. On the other hand, the study of paracetamol retention on the powdered activated carbon showed a high adsorption capacity of about 515.27 mg g−1. Isotherm data show a good fit with Langmuir's model. An infrared analysis is carried out. It shows identical bands before and after adsorption, with some modifications.
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Meler, Jan, Bożena Grimling, Maria Szcześniak, Janusz Pluta, and Paweł Biernat. "THE ADSORPTION OF SIMVASTATIN ON CHITOSANS IN AN IN VITRO PHARMACEUTICAL MODEL." Progress on Chemistry and Application of Chitin and its Derivatives XXII (September 30, 2017): 151–58. http://dx.doi.org/10.15259/pcacd.22.15.

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Rosli, Fatin Ahza, Haslina Ahmad, Khairulazhar Jumbri, Abdul Halim Abdullah, Sazlinda Kamaruzaman, and Nor Ain Fathihah Abdullah. "Efficient removal of pharmaceuticals from water using graphene nanoplatelets as adsorbent." Royal Society Open Science 8, no. 1 (January 2021): 201076. http://dx.doi.org/10.1098/rsos.201076.

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Recently, pharmaceutical pollutants in water have emerged as a global concern as they give threat to human health and the environment. In this study, graphene nanoplatelets (GNPs) were used to efficiently remove antibiotics sulfamethoxazole (SMX) and analgesic acetaminophen (ACM) as pharmaceutical pollutants from water by an adsorption process. GNPs; C750, C300, M15 and M5 were characterized by high-resolution transmission electron microscopy, Raman spectroscopy, X-ray diffraction and Brunauer–Emmett–Teller. The effects of several parameters viz. solution pH, adsorbent amount, initial concentration and contact time were studied. The parameters were optimized by a batch adsorption process and the maximum removal efficiency for both pharmaceuticals was 99%. The adsorption kinetics and isotherms models were employed, and the experimental data were best analysed with pseudo-second kinetic and Langmuir isotherm with maximum adsorption capacity (Q m ) of 210.08 mg g −1 for SMX and 56.21 mg g −1 for ACM. A regeneration study was applied using different eluents; 5% ethanol-deionized water 0.005 M NaOH and HCl. GNP C300 was able to remove most of both pollutants from environmental water samples. Molecular docking was used to simulate the adsorption mechanism of GNP C300 towards SMX and ACM with a free binding energy of −7.54 kcal mol −1 and −5.29 kcal mol −1 , respectively, which revealed adsorption occurred spontaneously.
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Al-Nimry, Suhair S., Shereen M. Assaf, Ibrahim M. Jalal, and Naji M. Najib. "Adsorption of ketotifen onto some pharmaceutical excipients." International Journal of Pharmaceutics 149, no. 1 (April 1997): 115–21. http://dx.doi.org/10.1016/s0378-5173(96)04857-0.

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Singh, G. N., and R. P. Gupta. "Adsorption Characteristics of Norfloxacin to Pharmaceutical Additives." Drug Development and Industrial Pharmacy 14, no. 13 (January 1988): 1845–54. http://dx.doi.org/10.3109/03639048809151991.

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Al-Khateeb, Lateefa A., Sitah Almotiry, and Mohamad Abdel Salam. "Adsorption of pharmaceutical pollutants onto graphene nanoplatelets." Chemical Engineering Journal 248 (July 2014): 191–99. http://dx.doi.org/10.1016/j.cej.2014.03.023.

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Feng, Zhaoxuan, Karin Odelius, Gunaratna Kuttuva Rajarao, and Minna Hakkarainen. "Microwave carbonized cellulose for trace pharmaceutical adsorption." Chemical Engineering Journal 346 (August 2018): 557–66. http://dx.doi.org/10.1016/j.cej.2018.04.014.

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Dissertations / Theses on the topic "Pharmaceutical Adsorption"

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Huang, Tongtong. "Protein adsorption and denaturation in injectable devices for pharmaceutical applications." Thesis, Mulhouse, 2016. http://www.theses.fr/2016MULH8373.

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Protéines sont largement utilisés dans la formulation dans le domaine pharmaceutique et de jouer un rôle important dans les fonctions biologiques. Il est bien connu que l'adsorption de protéines sur la surface solide est toujours observé pour un stockage à long terme, ce qui entraînera une réduction de la dose de substance active ou une perte de l'activité biologique. Dans certains cas, une courte période de contact avec la surface est suffisante pour modifier fortement la conformation des protéines : par exemple, l'insuline pertes 52% de son activité biologique après 5 minutes de contact avec la surface de verre, ainsi qu'une perte de 30% d’activité biologique du cétrorélix est observé après 2 heures de contact. Parmi tous les paramètres, la dénaturation des protéines est fortement liée à sa stabilité des propriétés de surface. La compréhension de l'adsorption de protéines est devenue une question cruciale dans l'industrie pharmaceutique.Pour mieux comprendre le comportement des protéines à la surface, la quantification des protéines adsorbées et sa conformation devrait être étudiée. L'objectif de notre recherche sera de comprendre les comportements des protéines sur différents surfaces de seringue pré - remplie classique.Le principal objectif de ce projet est de comprendre le comportement de plusieurs modèles de protéines comme la sérum d’albumine bovine (BSA), le lysozyme (LSZ) et la myoglobine (MGB) en contact avec des surfaces de seringues pré-remplie comme le verre et l’élastomère. Nous proposons d'utiliser la chromatographie liquide à haute performance (HPLC) pour la quantification de protéine adsorbée sur une surface plane en déterminant la déplétion des protéines en solution. La réflexion totale atténuée infrarouge à transformée de fourier (FTIR-ATR) spectroscopie est utilisée de suivre les changements structurels des protéines adsorbées sur des surfaces solides. [...]
Proteins are widely used in formulation in the pharmaceutical field and play a major role in biological functions. It is well known that protein adsorption on solid surface is always observed for a long-term storage, which will result in a reduced dose of active compound or a loss of biological activity. In some cases, only short time of contact are sufficient to drastically modify the protein conformation: for instance, insulin losses 52% of its biological activity after 5 minutes contacting with glass surface, as well as a loss of 30% of cetrorelix is observed after 2 hours. Among all parameters, the time frame of the denaturation process is strongly related to the protein stability and surface properties. The understanding of protein adsorption has therefore become a crucial issue in the pharmaceutical industry.To gain a better understanding of proteins’ behavior on the surface, adsorbed protein quantification and its conformation should be studied. The objective of our research in a first will be to understand proteins’ behaviors on various surfaces which composed a classical prefilled syringe.The main goal of this PhD project is to understand the behaviors of several model proteins like bovine serum albumin (BSA), lysozyme (LSZ) and myoglobin (MGB) in contact with the surfaces of prefilled syringes such as glass and elastomer. We propose to use the high performance liquid chromatography (HPLC) to quantify the amount of protein adsorbed on a flat surface by determining the depletion of the proteins in solution. Fourier transform infrared-attenuated total reflection (FTIR-ATR) spectroscopy was as well as employed to follow the structural changes of adsorbed BSA on solid surface. [...]
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Carthew, David Leonard. "Physico-chemical properties of poloxamer surfactants related to adsorption." Thesis, University College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.243418.

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Armstrong, Trevor Ian. "Protein adsorption onto polymeric nanoparticles : its relevance to drug targeting." Thesis, University of Nottingham, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.284047.

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Vutukuru, Naresh Kumar Reddy. "Apparent dissolution rate enhancement of poorly-water soluble drugs by adsorption technique." Scholarly Commons, 2015. https://scholarlycommons.pacific.edu/uop_etds/269.

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Nearly 70% of the new chemical entities (NCE’s) discovered are poorly-water soluble drugs and the number of poorly-water soluble drugs are increasing rapidly in the drug discovery. Most of the NCE’s are lipophilic and have dissolution rate issues. Low dissolution rate of the drugs result in poor bioavailability. To overcome poor bioavailability, an adsorption technique is developed to enhance the apparent dissolution rate of poorly-water soluble drugs. In this study, two poor-water soluble model drugs, ibuprofen and carvedilol were used. Methanol, DMF, DMSO and PEG400 were used as solvents and microcrystalline cellulose was used as an adsorbent. Pure model drugs, physical mixtures and prepared composites were characterized by using FTIR, DSC, XRD and dissolution testing. Results showed that the composites prepared with solvents DMF, DMSO and PEG400 showed enhancement in dissolution rates of two model drugs. Characterization of the composites prepared by using non-volatile solvents showed successful conversion of crystalline model drugs into solution state. Whereas, composites prepared by using volatile solvent showed similar results like physical mixtures and pure drug. Ibuprofen composites containing DMF, DMSO and PEG400 showed 9.4, 7.4 and 1.8 folds of increase in apparent dissolution rate, respectively. Whereas carvedilol composites containing DMF and DMSO showed 11.52 and 3.4 folds of increase in apparent dissolution rate. Four months of stability study were conducted on prepared composites at both 40°C and room temperature. It was observed that prepared composites were stable after 4 months and exhibited similar dissolution rate. In conclusion, the use of non-volatile solvents disrupted the crystal structure but also retained the drug in solution state which in turn enhanced the apparent dissolution rate of model drugs used. From the observed results we conclude that this method has a potential to replace existing techniques to enhance the apparent dissolution rate of the drug and stability of the composites.
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Machado, Ana Isabel de Oliveira. "Removal of pharmaceutical active compounds by constructed wetland systems - a sustainable phytoremediation technique?" Doctoral thesis, ISA, 2020. http://hdl.handle.net/10400.5/21195.

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Doutoramento em Restauro e Gestão Fluviais - Instituto Superior de Agronomia. Universidade de Lisboa
Emergent pollutants such as pharmaceutical active compounds (PhACs) have gained attention in the recent years since they can pose a threat to both river ecosystems and human health. The wide variety of pollutants in the market nowadays has overburdened the current wastewater treatment plants (WWTPs). Moreover, due to the increasingly growing society ecological awareness, environment friendly technologies have been more recently explored for wastewater treatment. Constructed wetlands (CWs) systems are an attractive example since they mimic natural processes such as pollutants filtration, phytoremediation and biodegradation but in a controlled form. The present thesis explore the potential of using locally available industry by products and native riparian wetland plants for enhancing the performance and implementation of CWs, for the removal of the highly consumed diuretic drug Furosemide. The state of art on the thesis subject was elaborated taking into account the situation in Portugal and in Brazil. Afterwards the validation of an analytical Furosemide quantification method through high performance liquid chromatography (HPLC-UV) in aqueous solution was performed taking in consideration the thesis projected experiments design. Light expanded clay aggregates and cork granulates were tested in terms of Furosemide adsorption capacity, showing both good removal values although with different adsorption ratio behaviours. A plant uptake experiment was performed with Iris pseudacorus to develop an analytical quantification method through HPLC-MS/MS for Furosemide in plant tissues. The PhAC was detected in the plants at residual concentrations hence limiting plant uptake capacity conclusions. Additionally, an experiment with both Iris pseudacorus and Typha domingensis was performed to study their uptake capacity, having both promoted similar removals of the PhAC. In overall, the tested components showed potential for CWs application and enhancement
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Ali, Shazia. "The adsorption characteristics of the poloxamer surfactants on model hydrophic drugs in suspension systems." Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.272211.

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Åsberg, Dennis. "Fundamental and Regulatory Aspects of UHPLC in Pharmaceutical Analysis." Doctoral thesis, Karlstads universitet, Institutionen för ingenjörs- och kemivetenskaper, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-47852.

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Ultra-high performance liquid chromatography (UHPLC) provides a considerable increase in throughput compared to HPLC and a reduced solvent consumption. The implementation of UHPLC in pharmaceutical analysis, e.g. quality control, has accelerated in recent years and there is currently a mix of HPLC and UHPLC instrumentation within pharmaceutical companies. There are, however, technical and regulatory challenges converting a HPLC method to UHPLC making it difficult to take full advantage of UHPLC in regulatory-focused applications like quality control in pharmaceutical production. Using chromatographic modelling and fundamental theory, this thesis investigated method conversion between HPLC and UHPLC. It reports on the influence of temperature gradients due to viscous heating, pressure effects and stationary phase properties on the separation performance. It also presents a regulatory concept for less regulatory interaction for minor changes to approved methods to support efficient life cycle management. The higher pressure in UHPLC gave a retention increase of up to 40% as compared to conventional HPLC while viscous heating, instead, reduced retention and the net result was very solute dependent. Selectivity shifts were observed even between solutes with similar structure when switching between HPLC and UHPLC and an experimental method to predict such selectivity shifts was therefore developed. The peak shape was negatively affected by the increase in pressure for some solutes since secondary interactions between the solute and the stationary phase increased with pressure. With the upcoming ICH Q12 guideline, it will be possible for the industry to convert existing methods to UHPLC in a more flexible way using the deeper understanding and the regulatory concept presented here as a case example.
Ultra-high performance liquid chromatography (UHPLC) provides a considerable increase in throughput compared to conventional HPLC and a reduced solvent consumption. The implementation of UHPLC in pharmaceutical analysis has accelerated in recent years and currently both instruments are used. There are, however, technical and regulatory challenges converting a HPLC method to UHPLC making it difficult to take full advantage of UHPLC in regulatory-focused applications like quality control in pharmaceutical production. In UHPLC, the column is packed with smaller particles than in HPLC resulting in higher pressure and viscous heating. Both the higher pressure and the higher temperature may cause changes in retention and selectivity making method conversion unpredictable. Using chromatographic modelling and fundamental theory, this thesis investigates method conversion between HPLC and UHPLC. It reports on the influence of temperature gradients due to viscous heating, pressure effects and stationary phase properties on the separation performance. It also presents a regulatory concept for less regulatory interaction for minor changes to approved quality control methods and how predicable method conversion is achieved by improved understanding.
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Gupta, Patel Salin. "MECHANISMS AND THERMODYNAMICS OF THE INFLUENCE OF SOLUTION-STATE INTERACTIONS BETWEEN HPMC AND SURFACTANTS ON MIXED ADSORPTION ONTO MODEL NANOPARTICLES." UKnowledge, 2019. https://uknowledge.uky.edu/pharmacy_etds/103.

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Nanoparticulate drug delivery systems (NDDS) such as nanocrystals, nanosuspensions, solid-lipid nanoparticles often formulated for the bioavailability enhancement of poorly soluble drug candidates are stabilized by a mixture of excipients including surfactants and polymers. Most literature studies have focused on the interaction of excipients with the NDDS surfaces while ignoring the interaction of excipients in solution and the extent to which the solution-state interactions influence the affinity and capacity of adsorption. Mechanisms by which excipients stabilize NDDS and how this information can be utilized by formulators a priori to make a rational selection of excipients is not known. The goals of this dissertation work were (a) to determine the energetics of interactions between HPMC and model surfactants and the extent to which these solution-state interactions modulate the adsorption of these excipients onto solid surfaces, (b) to determine and characterize the structures of various aggregate species formed by the interaction between hydroxypropyl methylcellulose (HPMC) and model surfactants (nonionic and ionic) in solution-state, and (c) to extend these quantitative relationships to interpret probable mechanisms of mixed adsorption of excipients onto the model NDDS surface. A unique approach utilizing fluorescence, solution calorimetry and adsorption isotherms was applied to tease apart the effect of solution state interactions of polymer and surfactant on the extent of simultaneous adsorption of the two excipients on a model surface. The onset of aggregation and changes in aggregate structures were quantified by a fluorescence probe approach with successive addition of surfactant. In the presence of HPMC, the structures of the aggregates formed were much smaller with an aggregation number (Nagg) of 34 as compared to micelles (Nagg ~ 68) formed in the absence of HPMC. The strength of polymer-surfactant interactions was determined to be a function of ionic strength and hydrophobicity of surfactant. The nature of these structures was characterized using their solubilization power for a hydrophobic probe molecule. This was determined to be approximately 35% higher in the polymer-surfactant aggregates as compared to micelles alone and was attributed to a significant increase in the number of aggregates formed and the increased hydrophobic microenvironment within these aggregates at a given concentration of surfactant. The energetics of the adsorption of SDS, HPMC, and SDS-HPMC aggregate onto nanosuspensions of silica, which is the model solid surface were quantified. A strong adsorption enthalpy of 1.25 kJ/mol was determined for SDS adsorption onto silica in the presence of HPMC as compared to the negligible adsorption enthalpy of 0.1 kJ/mol for SDS alone on the silica surface. The solution depletion and HPMC/ELSD methods showed a marked increase in the adsorption of SDS onto silica in the presence of HPMC. However, at high SDS concentrations, a significant decrease in the adsorbed amount of HPMC onto silica was determined. This was further corroborated by the adsorption enthalpy that showed that the silica-HPMC-SDS aggregation process became less endothermic upon addition of SDS. This suggested that the decrease in adsorption of HPMC onto silica at high SDS concentrations was due to competitive adsorption of SDS-HPMC aggregates wherein SDS is displaced/desorbed from silica in the presence of HPMC. At low SDS concentrations, an increase in adsorption of SDS was due to cooperative adsorption wherein SDS is preferentially adsorbed onto silica in the presence of HPMC. This adsorption behavior confirmed the hypothesis that the solution-state interactions between pharmaceutical excipients such as polymers and surfactants would significantly impact the affinity and capacity of adsorption of these excipients on NDDS surfaces.
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Wiser, Lauren Sample. "Mechanisms of polymer adsorption in nanoparticle stabilization for poorly water soluble compounds." Scholarly Commons, 2011. https://scholarlycommons.pacific.edu/uop_etds/159.

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In this dissertation, the mechanisms of nanosuspension stabilization via polymer adsorption on nanoparticle surface were investigated. As the electrokinetic behavior and colloidal stability depend on the surface characteristics, altering the surface adsorbed polymers affords the different surface properties of nanoparticles and leads to the insight on the mechanism of nanoparticle stabilization. Drug nanosuspensions were prepared by wet milling of drug with water as medium and polymers as stabilizers. Block copolymers were evaluated based on varying the hydrophobic and hydrophilic amounts, polymer concentration, and polymer affinity differences onto the nanoparticle surface. Specifically, block copolymers of ethylene oxide (EO) and propylene oxide (PO) with different EO chain lengths were used to modify the nanoparticle surface and investigate the mechanisms of stabilization by varying the ratio of hydrophobic (PO) and hydrophilic (EO) units. It was hypothesized that the PO chain of block copolymers adsorb at the solid-solution interface and the EO chain provides steric hindrance preventing aggregation. Block copolymer adsorption layer thicknesses were experimentally determined with adsorption layer thicknesses increasing from 4.7 to 9.5 nm as the number of EO increase from 26 to 133 monomer units. Nanoparticle aggregation occurred with insufficient polymer monolayer coverage and electrokinetic zeta potential greater than -20 mV. The amount of block copolymers on the surface of nanoparticles was quantified and the affinity of polymer adsorption increased as the copolymer hydrophobic units increased. The amount adsorbed and affinity provides a qualitative ranking of the affinities between a specific polymer and nanoparticle substrate to provide a method in determining the mechanism of stabilization, where specific functional groups for adsorption could be selected for maximum nanoparticle stability. A molecular modeling was conducted to visualize and support the mathematical model and the proposed mechanism of block copolymer adsorption onto a nanoparticle surface. The time lapse molecular modeling of a block copolymer in an aqueous media showed the hydrophobic units adsorbing onto the nanoparticle surface with the hydrophilic units projecting into the aqueous media. For the first time in pharmaceutical research, a systematic series of studies were conducted to elucidate the mechanisms of adsorption with both surface charge and polymer affinity analyses. A series of studies evaluating the adsorption properties polymer stabilizers provided useful information on how a block copolymer comprised of both hydrophilic and hydrophobic domains adsorbs onto an active pharmaceutical ingredient. A systematic set of experimental techniques were presented with novel analysis tools and predictors to construct stable nanoparticle formulations.
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Buyuktimkin, Tuba. "The influence of the adsorption of metoclopramide and related benzamides on the ionization of the silica surface." Diss., University of Iowa, 2011. https://ir.uiowa.edu/etd/2676.

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The drug metoclopramide was found to adsorb to the unionized and ionized silica surface. The primary objective of this research was to use potentiometric titration in order to study the specificity of the interactions of benzamide analogs with the hydroxyl groups, silanols, on the Aeroperl® silica surface. Mass titration studies showed that the acidity of surface silanols increases with dissolved metoclopramide and similar compounds. The nature of the interaction was concluded to involve a physical adsorption process. A different potentiometric titration method was devised to determine the ionization of silanols in the presence of a dissolved compound with solubility limitations. This method was found to give similar results as that described in the literature. The presence of dissolved metoclopramide was found to cause a large increase in the density of the negatively charged silanols on the silica surface. The ionization of silica was dependent on the concentration of dissolved metoclopramide at low pH but was found to be constant over a wide concentration range at pH 7.0 or higher. Adsorption studies with unionized silica indicated that specific interactions with the surface silanols occur as well as non-specific interactions driven by hydrophobic bonding with the surface siloxane groups. There was an increase in the adsorption of metoclopramide with increasing ionization of the silica surface which suggested that the negatively charged silanols constituted an additional adsorption site. The mechanism of the interaction was elucidated by potentiometric titration with various probe compounds. The titration data with lidocaine suggested that the ionization of the surface silanols is influenced by specific interactions with the adsorbed compound rather than concentration effects. The ionized site density of silica was found to be related to the relative magnitude of the aromatic π-electron density of the adsorbed benzamides. A comparison of these titration data with that of triethylamine indicated that ionic interactions between the positively charged amine groups and the negatively charged silanols are likely to be occurring. Based on the difference in chemical structure, the titration data with dissolved ephedrine indicated that the other site of interaction is likely to be between the carbonyl oxygen of the adsorbed benzamides and the unionized silanols. The pH dependence of the ionization of silanols for both adsorption sites suggested that silanols interact simultaneously with several functional groups on a single adsorbed molecule.
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Books on the topic "Pharmaceutical Adsorption"

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Gurramkonda, Neha Mallika, and Dr Bala Narsaiah Tumma. Pharmaceutical wastewater treatment using TIO2 &N-TIO2 nanoparticles: Integration of adsorption and photocatalysis. LAP LAMBERT Academic Publishing, 2019.

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Walters, Kenneth A. Dermatological and Transdermal Formulations (Drugs and the Pharmaceutical Sciences). Informa Healthcare, 2002.

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Walters, Kenneth A. Dermatological And Transdermal Formulations (Drugs and the Pharmaceutical Sciences). Marcel Dekker Inc, 2002.

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1954-, Grassi Mario, ed. Understanding drug release and absorption mechanisms: A physical and mathematical approach. Boca Raton: CRC Press, 2007.

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Understanding drug release and absorption mechanisms: A physical and mathematical approach. Boca Raton, FL: CRC/Taylor & Francis, 2007.

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Olkkola, Klaus T., Hugo E. M. Vereecke, and Martin Luginbühl. Drug interactions in anaesthetic practice. Edited by Michel M. R. F. Struys. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199642045.003.0021.

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When two or more drugs are administered simultaneously, the pharmacological response may be greater or less than the sum of the effects of the individual drugs. One drug may antagonize or potentiate the effects of the other and there may be also qualitative differences in response. Although some drug interactions increase the toxicity or result in loss of therapeutic effect, others are beneficial. Indeed, modern anaesthetic techniques depend on beneficial drug interactions. A sound combination of drugs helps clinicians to increase both the efficacy and safety of drug treatment. Drugs may interact on a pharmaceutical, pharmacodynamic, or pharmacokinetic basis. Many pharmacodynamic interactions are predictable and can be avoided by the use of common sense. However, it is much more difficult to predict the likelihood of pharmacokinetic and pharmaceutical interactions despite good prior knowledge of pharmacokinetics and chemical properties of individual drugs. Pharmaceutical drug interactions usually occur before the drug is given to the patient and they are caused by chemical (such as acid–base, salt formation, oxidation–reduction, hydrolysis, or epimerization) or physical (such as adsorption/absorption or emulsion breaking) reactions. When drugs have a pharmacokinetic interaction, one drug alters the absorption, distribution, or the elimination of the other drug. Many pharmacokinetic drug interactions are due to inhibition or induction of cytochrome P450 enzymes. Pharmacodynamic drug interactions are caused by drugs having an effect on the same receptors or the same physiological system. This chapter gives anaesthetists an overview of clinically relevant perioperative drug interactions.
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Malmsten, Martin. Surfactants and Polymers in Drug Delivery (Drugs and the Pharmaceutical Science, 122). Informa Healthcare, 2002.

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Understanding Drug Release and Absorption Mechanisms: A Physical and Mathematical Approach. CRC, 2006.

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Shubietah, Raqi Mohammad Hasan. Adsorptive stripping voltammetry as a method of analysis of some pharmaceutical and other purine derivatives. 1995.

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Book chapters on the topic "Pharmaceutical Adsorption"

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Sharma, Atul, and Saif Ali Chaudhry. "Adsorption of Pharmaceutical Pollutants Using Lignocellulosic Materials." In Green Materials for Wastewater Treatment, 277–89. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-17724-9_12.

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Bishop, J. F., T. H. Mourey, and J. Texter. "Adsorption of Triblock Copolymers on Nanoparticulate Pharmaceutical Imaging Agents." In ACS Symposium Series, 205–16. Washington, DC: American Chemical Society, 1996. http://dx.doi.org/10.1021/bk-1995-0615.ch013.

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Li, Ping, Pedro Ferreira Gomes, José M. Loureiro, and Alirio E. Rodrigues. "Proteins Separation and Purification by Expanded Bed Adsorption and Simulated Moving Bed Technology." In Continuous Processing in Pharmaceutical Manufacturing, 1–34. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2014. http://dx.doi.org/10.1002/9783527673681.ch01.

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Cherif, S., M. R. Boudraa, A. Moussa, R. Maachi, N. Nasrallah, and N. Guendouz. "Degradation of a Pharmaceutical Pollutant by Coupling Photo-Fenton and Adsorption Processes." In Proceedings of the Third International Symposium on Materials and Sustainable Development, 580–92. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-89707-3_62.

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Mdlalose, L., V. Chauke, N. Nomadolo, P. Msomi, K. Setshedi, L. Chimuka, and A. Chetty. "Metal Oxide Nanocomposites for Adsorption and Photoelectrochemical Degradation of Pharmaceutical Pollutants in Aqueous Solution." In Nanostructured Metal-Oxide Electrode Materials for Water Purification, 167–89. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-43346-8_10.

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Ahmad Ganai, Sajad, and Amjad Mumtaz Khan. "Water Treatment: Applications of Adsorption and Ion Exchange Chromatography in the Chemical, Pharmaceutical, and Food Industries." In Applied Food Science and Engineering with Industrial Applications, 233–46. Toronto; New Jersey: Apple Academic Press, 2019.: Apple Academic Press, 2019. http://dx.doi.org/10.1201/9781351048644-12.

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Khadir, Ali, Afsaneh Mollahosseini, Ramin M. A. Tehrani, and Mehrdad Negarestani. "A Review on Pharmaceutical Removal from Aquatic Media by Adsorption: Understanding the Influential Parameters and Novel Adsorbents." In Nanotechnology in the Life Sciences, 207–65. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-42284-4_8.

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Arya, V., and Ligy Philip. "Removal of Pharmaceuticals from Water Using Adsorption." In Trends in Asian Water Environmental Science and Technology, 105–14. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-39259-2_9.

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Vire, J. C., G. J. Patriarche, H. Zhang, B. Gallo, and R. Alonso. "Adsorptive Stripping Square wave Voltammetry of Pharmaceutical Quinonic Derivatives." In Contemporary Electroanalytical Chemistry, 379–86. Boston, MA: Springer US, 1990. http://dx.doi.org/10.1007/978-1-4899-3704-9_44.

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Zaman, Dina, Manoj Kumar Tiwari, and Swati Mishra. "Low-Cost Adsorptive Removal Techniques for Pharmaceuticals and Personal Care Products." In Energy, Environment, and Sustainability, 397–421. Singapore: Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-15-0540-9_19.

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Conference papers on the topic "Pharmaceutical Adsorption"

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Lember, Erki, Karin Pachel, and Enn Loigu. "Adsorption of Diclofenac, Sulfamethoxazole and Levofloxacin with Powdered Activated Carbon." In Environmental Engineering. VGTU Technika, 2017. http://dx.doi.org/10.3846/enviro.2017.082.

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The presence of pharmaceutical residues in the receiving waterbodies of wastewater treatment plants (WWTP) and in the environment has become a global concern. We can now say for certain that, having metabolised in our bodies, partially modified or unmodified pharmaceuticals will reach WWTP. However, WWTP are not designed for the removal of such com-pounds. Only a small fraction of pharmaceuticals decompose during biological treatment or are adsorbed in sediment. There-fore, it is essential to find a treatment process that is capable of removing pharmaceutical residues. The aim of the present study was to research the removal of three pharmaceuticals found in the environment, namely diclofenac (DCF), sulfamethoxazole (SMX) and levofloxacin (LFX), through the use of powdered activated carbon (PAC). To this end, adsorption tests were con-ducted where the adsorption capacity was estimated according to the adsorbent dose and the residence time of the process. LFX had the highest adsorption rate: the removal effectiveness was 77% in a residence time of 5 minutes and in 60 minutes a stable indicator was achieved whereby 94% of LFX had become adsorbed. The worst adsorption property was observed for SMX, as 68% of SMX was adsorbed in a residence time of 60 minutes. According to the conducted tests, the Freundlich adsorption isotherms and constants characterising the adsorption were found where the DCF K was 23.8, the SMX K was 34.3 and the LFX K was 106.1. This test demonstrated that the pharmaceuticals selected for the experiment could easily be subjected to adsorption processes and could be removed by means of PAC.
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Guzman, Paulina, Natalie Medlicott, Thomas Rades, Lene Jorgensen, and Stefania Baldursdottir. "Studying the adsorption of protein at the oil-water interface." In The 2nd Electronic Conference on Pharmaceutical Sciences. Basel, Switzerland: MDPI, 2012. http://dx.doi.org/10.3390/ecps2012-00813.

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Liu, Feng-hua, Yong-hui Song, Ping Zeng, Jian-feng Peng, Shu-hu Xiao, Liang Duan, Guang-lei Qiu, Jie Ye, and Cun-yi Song. "Adsorption Characteristics of Cu2+ onto Zeolite from Pharmaceutical Industrial Wastewater." In 2011 International Conference on Computer Distributed Control and Intelligent Environmental Monitoring (CDCIEM). IEEE, 2011. http://dx.doi.org/10.1109/cdciem.2011.17.

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Baldursdottir, Stefania, Lene Jorgense, Maria Støier Fullerton, and Signe Hougaard Nielsen. "Comparison of Two Methods Detecting Lysozyme Adsorption to Oil-water Interface in the Presence of Surfactants." In The 1st Electronic Conference on Pharmaceutical Sciences. Basel, Switzerland: MDPI, 2011. http://dx.doi.org/10.3390/ecps2011-00508.

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Ribeiro, A., C. Vilarinho, J. Araújo, and J. Carvalho. "Development of an Integrated Process for Eggshell Valorization." In ASME 2014 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/imece2014-38836.

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The current global trend towards more stringent environmental standards, technical applicability and cost-effectiveness, became key factors in the selection of adsorbents. After demonstrating the performance of eggshell-derived adsorbent under a range of lab operating conditions, this work focused the adsorption efficiency of calcined eggshell powder (CEP), in the treatment of wastewaters from different industrial units. In order to do it, the removal of organic material, expressed as chemically oxygen demand (COD), was monitored in leachate wastewaters from sanitary landfill (LLWW) and in municipal residual wastewaters (MWW). Furthermore, the efficiency of alkaline metals removal, specifically from effluents of industrial unites from superficial treatments, was also assessed. A detailed study of the eggshell characteristics, before and after the adsorption process, was carried out, aiming at investigate the adsorption mechanism underlying the removal of different pollutants. Results demonstrate that adsorption of organic material and metals in the CEP, go around 84% of organic material removal in MWW and 81% in LLWW. Finally, a removal of 95% of aluminium (Al) from MWW, deriving from anodizing industrial plant, and a removal of 88% copper (Cu), 95% chromium (Cr) and 30% nickel (Ni) from effluents of superficial treatments produced in Ni/Cr plating plants, were also determined This suggests that CEP adsorbent is appropriated to wastewaters treatment with high contents of organic matter and heavy metals, from different aqueous systems or different industries. The application of this adsorbent in this methodology showed good cost-benefits ratio, proving that it can be an effective alternative to activated carbon. However, aiming the progress and sustainability of the whole eggshell valorisation, we are further optimizing, testing and developing new techniques and products to recover the organic fraction of the eggshell through the reclamation of several bioactive peptides derived from hydrolysis of different proteins that constitute these residues. These products are intended to be introduced in the food, cosmetic and pharmaceutical markets.
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