Relevant bibliographies by topics / Pharmaceutical chemistry – Research

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Pharmaceutical chemistry – Research'

Author: Grafiati
Published: 4 June 2021
Last updated: 11 February 2022

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Journal articles on the topic "Pharmaceutical chemistry – Research"

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Dai, Qi Chang, Cui Ting Chen, Miao Yu, and Yu Bin Ji. "New Research on the Pharmaceutical Chemistry of Plant Polysaccharides." Applied Mechanics and Materials 411-414 (September 2013): 3237–41. http://dx.doi.org/10.4028/www.scientific.net/amm.411-414.3237.

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The researches on plant polysaccharides develop rapidly in recent years. In this paper, the studies of pharmaceutical chemistry of polysaccharides from plants are reviewed. We introduce researches’ new progresses and results of the extraction, separation and purification in the field of pharmaceutical chemistry and expound the advantages and disadvantages of the applications of physical techniques, chemical technology and biotechnology. The applications of statistic principles in the field of medicinal chemistry are also discussed in this article.
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Saxena, Sanjai, Manmohan Chhibber, and Inder Pal Singh. "Fungal Bioactive Compounds in Pharmaceutical Research and Development." Current Bioactive Compounds 15, no. 2 (March 12, 2019): 211–31. http://dx.doi.org/10.2174/1573407214666180622104720.

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Background:Exploration of antibiotics from microorganisms became widespread in the academia and the industry with the serendipitous discovery of Penicillin from Penicillium notatum by Sir Alexander Fleming. This embarked the golden era of antibiotics which lasted for over 60 years. However, the traditional phenotypic screening was replaced with more rational and smarter methods of exploration of bioactive compounds from fungi and microorganisms. Fungi have been responsible for providing a variety of bioactive compounds with diverse activities which have been developed into blockbuster drugs such as Cyclosporine, Caspofungin, Lovastatin and Fingolimod etc. It has been reported that ca. 40% of the 1453 New Chemical Entities (NCE’s) approved by USFDA are natural products, natural product inspired or mimics many of which have their origins from fungi. Hence fungal compounds are playing a very important role in drug discovery and development in the pharmaceutical industry.Methods:We undertook structured searches of bibliographic databases of peer-reviewed research literature which pertained to natural products, medicinal chemistry of natural products and drug discovery from fungi. With the strategic improvement in screening and identification methods, fungi are still a potential resource for novel chemistries. Thus the searches also comprised of bioactive agents from fungi isolated or derived from special ecological groups and lineages. To find different molecules derived or isolated from fungi under clinical studies, clinical trial data from the NIH as well as from pharmaceutical companies were also explored. This comprised of data wherein the pharmaceutical industries have acquired or licensed a fungal bioactive compound for clinical study or a trial.Results:Natural product chemistry and medicinal chemistry continue to play an important role in converting a bioactive compound into therapeutic moieties or pharmacophores for new drug development.Conclusion:Thus one can say fungal bioactive compounds are alive and well for development into new drugs as novel ecological groups of fungi as well as novel chemistries are being uncovered. This review further emphasizes the collaboration of fungal biologists with chemists, pharmacologists and biochemists towards the development of newer drugs for taking them into the drug development pipeline.
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Bajorath, Jürgen. "Computational chemistry in pharmaceutical research: at the crossroads." Journal of Computer-Aided Molecular Design 26, no. 1 (November 15, 2011): 11–12. http://dx.doi.org/10.1007/s10822-011-9488-z.

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Pawson, Beverly A. "Medicinal Chemistry: The Role of Organic Chemistry in Drug Research." Journal of Pharmaceutical Sciences 75, no. 8 (August 1986): 828. http://dx.doi.org/10.1002/jps.2600750837.

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Bryan, Marian C., Peter J. Dunn, David Entwistle, Fabrice Gallou, Stefan G. Koenig, John D. Hayler, Matthew R. Hickey, et al. "Key Green Chemistry research areas from a pharmaceutical manufacturers’ perspective revisited." Green Chemistry 20, no. 22 (2018): 5082–103. http://dx.doi.org/10.1039/c8gc01276h.

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The ACS Green Chemistry Institute® Pharmaceutical Roundtable has assembled an updated list of key research areas to highlight transformations and reaction media where more sustainable technologies would be most impactful.
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Swaan, Peter W. "Pharmaceutical Research—Looking Ahead." Pharmaceutical Research 26, no. 3 (January 22, 2009): 491. http://dx.doi.org/10.1007/s11095-009-9836-z.

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Nisiwaki, Masanori. "Green Chemistry in Process Research and Development in Pharmaceutical Industry." Journal of Synthetic Organic Chemistry, Japan 61, no. 5 (2003): 464–71. http://dx.doi.org/10.5059/yukigoseikyokaishi.61.464.

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Campeau, Louis-Charles, and Deryn E. Fogg. "The Roles of Organometallic Chemistry in Pharmaceutical Research and Development." Organometallics 38, no. 1 (January 14, 2019): 1–2. http://dx.doi.org/10.1021/acs.organomet.8b00918.

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Constable, David J. C., Peter J. Dunn, John D. Hayler, Guy R. Humphrey, Johnnie L. Leazer, Jr., Russell J. Linderman, Kurt Lorenz, et al. "Key green chemistry research areas—a perspective from pharmaceutical manufacturers." Green Chem. 9, no. 5 (2007): 411–20. http://dx.doi.org/10.1039/b703488c.

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Lupascu, Naliana, Emin Cadar, Melat Cherim, Cristina Luiza Erimia, and Rodica Sîrbu. "Research Concerning the Efficiency of Aronia Melanocarpa for Pharmaceutical Purpos." European Journal of Interdisciplinary Studies 2, no. 1 (April 30, 2016): 115. http://dx.doi.org/10.26417/ejis.v2i1.p115-121.

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The major impact of many types of disease on the human body have generated medical research orientation toward biotechnology identification and extraction of active principles from natural resources. The social problem to improve the health of the population, to maintain social balance of a healthy society oriented medical-pharmaceutical research for the use of other sources of pharmaceuticals from natural sources and not synthetic chemistry. On this line of work is also included the research wich orientates pharmaceutical medical studies by using new sources of bioactive compounds such as: anthocyanes, flavonoids, phenolic acids, chlorogenic acid, tannins, vitamin P,C, B2, B6 from the shrub Aronia Melanocarpa. Besides these compounds are also found in the fruits different cyanidin glycosides: 3-galactoside, 3-glucoside, 3-arabinoside and 3-xyloside. The rich content in bioactive forms makes possible the use in treating certain diseases by using internal use in household. For internal use are used by diabetics having hypoglycemic effect, astringent properties and very strong diuretics, they are cardiac tonic, regulates blood pressure and blood glucose, treatment of varicose veins and hemorrhoids, it has a good hepatoprotective effect due to its high iodine content , are effective in hyperthyroidism and can be consumed by sufferers of Alzheimer's disease and relieving symptoms slowig the aging processes.
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Dissertations / Theses on the topic "Pharmaceutical chemistry – Research"

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Faulkner, W. "Linkage between industrial and academic research : The case of biotechnological research in the pharmaceutical industry." Thesis, University of Sussex, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.373169.

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This thesis is a study of research linkage between industry and academia. It concentrates on the industrial side of these interactions and, in particular, the impact of information flows from academia industrial innovation. Specifically, the study explores the proposition that linkage varies - in extent and nature according to the stage of development of the research field involved. A review of the literature suggested that linkage should be particularly strong in a nascent technology, such as that unfolding currently in biotechnology. The field study involved face-to-face interviews with industrial researchers from UK pharmaceutical companies and from new start-up companies. It was designed in order to ascertain the relative strength of linkages in the new biotechnology; to characterize these linkages; and to explore how they might change as the technology develops. It is ~emonstrated that linkage is indeed strong here, involving lntensive 'search' activities and often substantial formal collaboration with academia. The background material collected - concerning the role of linkage in innovation and in corporate strategies for biotechnology confirm that companies are obliged to 'plug in' to academic research precisely because 'of the dynamism and uncertainty which characterizes a new technological field. It is argued that those pharmaceutical companies which are interacting most with academic research are also those which are most likely to succeed commercially with the new techniques. The start-up companies in biotechnology are shown to have extremely close links with both academia and the large established companies active in the field. It is argued that the very presence of such companies is itself symptomatic of the proximity of academic science and industrial technology in this new field. In conclusion, it is suggested that the pattern of linkage found in biotechnology may well ~ertain in other new science-based fields; some policy lmplications are discussed.
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Randall, Elizabeth Claire. "Development and integration of chemical imaging methods for applications in biomedical and pharmaceutical research." Thesis, University of Birmingham, 2017. http://etheses.bham.ac.uk//id/eprint/7602/.

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Imaging of biomolecules in biological substrates by mass spectrometry or spectroscopic imaging techniques plays a major role in biomedical, clinical, and pharmaceutical research. The work presented in this thesis investigates the capabilities of three imaging techniques, liquid extraction surface analysis (LESA) mass spectrometry imaging (MSI), matrix assisted laser desorption ionisation (MALDI) MSI and stimulated Raman scattering (SRS) microscopy. A method for combined LESA and MALDI analysis was developed and results provided high resolution imaging of multiple analyte classes (proteins, lipids and small molecule drugs) in thin tissue sections. SRS microscopy was used for the quantitative imaging of MALDI sampling effects and sample preparation, providing insight into fundamental processes of MALDI MS. Multimodal SRS, LESA and MALDI imaging was executed on a single tissue sample revealing the complementarity between the three approaches. Specific challenges for LESA were further explored, namely quantification, improved spatial resolution and alternative biological substrates. A quantitative LESA method based on the production of mimetic tissue models containing stable isotope-labelled proteins was developed. An alternative platform, the Flow-Probe™, with the potential to achieve higher spatial resolution was assessed. Finally, a LESA method for the direct analysis of proteins from live bacterial colonies was developed.
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Batlokwa, Bareki Shima. "Development of molecularly imprinted polymer based solid phase extraction sorbents for the selective cleanup of food and pharmaceutical residue samples." Thesis, Rhodes University, 2012. http://hdl.handle.net/10962/d1004967.

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This thesis presents the development of chlorophyll, cholic acid, aflatoxin B1 molecularly imprinted polymer (MIP) particles and cholic acid MIP nanofibers for application as selective solid phase extraction (SPE) sorbents. The particles were prepared by bulk polymerization and the nanofibers by a novel approach combining molecular imprinting and electrospinning technology. The AFB1 MIP particles were compared with an aflatoxin specific immunoextraction sorbent in cleaning-up and pre-concentrating aflatoxins from nut extracts. They both recorded high extraction efficiencies (EEs) of > 97 % in selectively extracting the aflatoxins (AFB1, AFB2, AFG1 and AFG2). High reproducibility marked by the low %RSDs of < 1% and low LODs of ≤ 0.02 ng/g were calculated in all cases. The LODs were within the monitoring requirements of the European Commission. The results were validated with a peanut butter certified reference material. The chlorophyll MIP on the other hand selectively removed chlorophyll that would otherwise interfere during pesticide residue analysis (PRA) from > 0.6 to <0.09 Au in green plants extracts. The extracted chlorophyll was removed to far below the level of ≥ 0.399 Au that is usually associated with interference during PRA. Furthermore, the MIP demonstrated better selectivity by removing only chlorophyll (> 99%) in the presence of planar pesticides than the currently employed graphitized carbon black (GCB) that removed both the chlorophyll (> 88%) and planar pesticides (> 89%). For the interfering cholic acid during drug residue analysis, cholic acid MIP electrospun nanofibers demonstrated to be more sensitive and possessing higher loading capacity than the MIP particles. 100% cholic acid was removed by the nanofibers from standard solutions relative to 80% by the particles. This showed that the nanofibers have better performance than the micro particles and as such have potential to replace the particle based SPE sorbents that are currently in use. All the templates were optimally removed from the prepared MIPs by employing a novel pressurized hot water extraction template removal method that was used for the first time in this thesis. The method employed only water, an environmentally friendly solvent to remove templates to ≥ 99.6% with template residual bleeding of ≤ 0.02%.
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Vernon, John A. "The economics of pharmaceutical research development : investment models, capital market imperfections and policy considerations." Thesis, City University London, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367264.

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Desai, Suketu Dipakbhai. "Formulation of controlled release ocular delivery systems of pilocarpine." Diss., The University of Arizona, 1992. http://hdl.handle.net/10150/185894.

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The main objective of this work was to develop Poloxamer 407 (Pluronic F127)-based formulations for controlled ocular delivery of pilocarpine as a model drug. Various additives such as polyethylene glycol, polyvinyl alcohol, polyvinylpyrrolidone, methylcellulose (MC) and hydroxypropyl methylcellulose (HPMC), were incorporated into formulations containing 25% PF127, 1% pilocarpine hydrochloride (PHCL) alone or containing one of the additives. The release of PHCL from the PF127 formulations and the dissolution profile of the formulations are obtained simultaneously at RT and 34°C. The formulations with 25% PF127, 1% PHCL and either 5% MC or 3% HPMC showed the slowest dissolution and also released the drug the slowest of the formulations evaluated in vitro. The PHCL release from the two formulations exhibited a zero-order release and the mechanism of PHCL release seem to be dissolution controlled. Therefore the MC- and HPMC-containing PF127 formulations of PHCL were selected for further in-vivo studies. The miotic response to equal administered volumes of an isotonic solution of 1% PHCL and the MC-containing PF127 formulation of PHCL was measured. The PF127 formulation showed a statistically significant increase in the duration of miosis and the intensity of the miotic response (i.e., higher ocular bioavailability) compared to the same instilled volume of the Isotonic PHCL solution. In the next phase of this work pilocarpine-incorporated polyisobutylcyanoacrylate nanocapsules (PIBCA-NC) were prepared, characterized in vitro and evaluated in vivo in albino rabbit eyes. Here the PIBCA-NC of PHCL containing 1% pilocarpine, of which about 13.5% was incorporated into the nanocapsules, were administered alone or using the aforementioned MC-containing PF127 formulation with 25% PF127 and 5% MC as a vehicle. The in vivo results indicated that the PIBCA-NC dispersion of 1% pilocarpine, when administered using the MC-containing PF127 gel vehicle, significantly improved the duration and the intensity of the miotic response compared to the administration of the same volume of the PIBCA-NC dispersion of 1% pilocarpine alone. Therefore, the PF127 formulations of pilocarpine developed and evaluated thus far, offer considerable promise in terms of their potential to be used for the controlled release ocular delivery of pilocarpine.
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Chichetu, Karen. "Characterization, DNA Binding and Cleavage Activities of New Prodigiosin and Tambjamine Analogues and Their Cu²⁺ and Zn²⁺ Complexes." PDXScholar, 2015. http://pdxscholar.library.pdx.edu/open_access_etds/2467.

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Prodigiosins and tambjamines are natural compounds from bacterial and marine sources belonging to a family containing a common 4-methoxy-2,2'-bipyrrole core. These compounds have received a lot of interest due to their promising biological activities. Studies have suggested DNA as a potential therapeutic target for the natural prodigiosin and tambjamine due to their ability to facilitate oxidative DNA cleavage in the presence of Cu2+. Based on this we sought to study the metal binding activity of new prodigiosin and tambjamine analogues. A new prodigiosin analogue was synthesized and complexed with Cu2+. This revealed 1:1 complex formation between the tripyrrole and Cu2+ that was confirmed by mass spectra and NMR spectra analysis. In addition in situ studies also revealed that our new analogues of prodigiosin cannot bind Zn2+ when the methoxy group on ring B is replaced by an alkyl group or when one of the ring nitrogens is methylated. Our UV-Vis experiments with calf thymus DNA showed that prodigiosins and tambjamines bind DNA mainly through an external mode, suggesting that hydrogen bonding between the pyrrole ring nitrogens and the bases of DNA takes precedence over stacking interactions. For the new Cu2+ complex synthesized however, we observed spectral changes that suggest intercalation into DNA. DNA cleavage experiments revealed that the prodigiosin-Cu complex is able to convert supercoiled DNA into its linear form. The data from the gel shift assays fit well to a first-order consecutive reaction model. In addition to preformed metal complexes, we showed DNA cleavage by in situ complexation of the ligands in the presence of Cu2+. However, although we showed Zn2+ complex formation with prodigiosin analogues, in situ studies did not show induction of DNA cleavage by Zn2+ complexes under our experimental conditions.
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Mandimika, Nyaradzo. "Evaluation of the pharmaceutical availability of erythromycin from topical formulations." Thesis, Rhodes University, 2008. http://eprints.ru.ac.za/1176/.

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Dagnolo, Bianca. "The development of an orodispersible sildenafil citrate tablet intended for paediatric use." Thesis, Rhodes University, 2012. http://hdl.handle.net/10962/d1003229.

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Sildenafil citrate (SC) is a phosphodiesterase-5 inhibitor that is used to treat pulmonary hypertension (PH) in paediatric patients. The purpose of these studies was to develop a formulation and manufacture an orodispersible tablet (ODT) that can be easily administered to neonates and children with PH. The advantages of ODT dosage forms include ease of administration, rapid dissolution of the API, SC. Furthermore the dosage form can be taken without water which is beneficial to patients without immediate access to potable fluids. A simple, rapid, accurate, precise and selective reversed-phase HPLC method was developed and validated in accordance with International Conference on Harmonization (ICH) guidelines and was successfully used for the analysis of SC as raw material and in SC containing pharmaceutical dosage forms. Preformulation studies were performed on SC, alone and in combination with potential excipients that could be used to make tablets. Investigations into potential interactions between SC and the excipients were performed using Differential Scanning Calorimetry (DSC) and Infrared Spectroscopy (IR). DSC results revealed that SC was compatible with all potential excipients except mannitol and magnesium stearate. However these interactions were not observed with IR and therefore it was concluded that the interactions were induced by the high temperatures that DSC operates at. Particle size and shape was also established by use of Scanning Electron Microscopy (SEM) and flow properties were monitored by calculating Carr’s Index (CI) and the Hausner Ratio (HR). Direct compression was used as the method of manufacture for SC tablets as this approach is simple and the most economic production approach. The powder blends were assessed for bulk and tapped density and the CI and HR were used to determine the flowability of the blends. The quality attributes of the resultant tablets that were monitored included uniformity of weight, friability, crushing strength, tensile strength, disintegration, wetting and in vitro dispersion times. Design of Experiments is an efficient statistical approach that has become a popular tool used in the pharmaceutical industry to optimize formulation compositions, as it allows for the investigation of several input factors at the same time whilst not using the tedious and traditional “ modification of one variable at a time” approach. A Central composite experimental design was chosen as the most appropriate means to optimize the formulation as it produces more accurate results as opposed to other experimental designs approaches as input factors are investigated at five different levels. Through the use of mathematical modelling, optimum concentrations of disintegrant(s) and an appropriate blending time were established. Analysis of the data from the experimental design and mathematical modelling studies reveal that no changes in disintegrant concentration or blending time altered the disintegration time of the formulation to any significant extent. This result is most likely due to the fact that the critical disintegrant concentration has been reached and increasing the disintegrant concentration further has no effect on disintegration time. It was also established that a change in the concentration of CMS and CRP altered the wetting time of the tablet significantly. Finally it was noted that there was a linear relationship between blending time and the uniformity of content of the tablets produced in these studies. The optimized product was a white tablet with a diameter of 7.31 mm with a thickness of 2.80mm.The dosage form had no visible cracks or evidence of picking or sticking. The tablet exhibits suitable friability and tensile strength while exhibiting a disintegration time of only 8s. Therefore an orodispersible tablet containing SC intended for paediatric use has been successfully developed, manufactured and optimized through the use of preformulation studies, appropriate quality control monitoring and mathematical modelling. These formulations require further optimization in respect of addition of flavours and or additional sweetening agents.
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Liao, Yueh Ying. "The Reaction of a Water Soluble Platinum Compound with Methionine and Derivatives." TopSCHOLAR®, 2010. http://digitalcommons.wku.edu/theses/153.

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Water soluble platinum complexes are a recent area of emphasis of cisplatin chemistry. The water soluble complexes could have a reduced toxicity compared with cisplatin. Oxaliplatin, which has an oxalate leaving group, has previously been shown to have less nephro-toxicity and higher water solubility than cisplatin. [Pt(en)(oxalate)] (en = ethylenediamine) has been prepared from Pt(en)Cl2 and silver oxalate. This complex has been reacted with methionine and N-acetylmethionine at different molar ratios. At high Pt: methionine ratios, chelates with the sulfur and nitrogen atoms of the methionine are dominant; at lower Pt: methionine ratios, a bis-methionine product is formed. The en ligand is displaced by methionine but not N-acetylmethionine.
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Wahl, Troy Andrew. "Developing Thyronamine Analog Pharmaceuticals Targeting TAAR1 to Treat Methamphetamine Addiction." PDXScholar, 2013. https://pdxscholar.library.pdx.edu/open_access_etds/1109.

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As a part of the overall program in the Grandy laboratory at Oregon Health & Science University (OHSU), studying the underlying chemical biology of methamphetamine (Meth) addiction, this dissertation reports on the development of six new thyronamine analogs which were synthesized and assayed against trace amine associated receptor 1 (TAAR1), giving preliminary results consistent with the analogs being inverse agonists. Due to highly variable TAAR1 expression levels in the assays, based on inter-assay response to control Meth stimulation as well as other possible factors, kinetic models were developed to qualitatively explain the assay results. The models set approximate limits on the analogs' binding and disassociation rates relative to those of Meth. Analysis of the assays also provides more evidence of TAAR1's basal activity. Based on the models, the conversion rate of ligand-free inactive TAAR1 to ligand-free active TAAR1 is less than 6% of the binding rate of Meth to TAAR1. The models also suggest that the inverse agonists bind to the inactive ligand-free form of TAAR1 between 10 and 100 times faster than Meth binds to the inactive ligand-free form of TAAR1. Three of the new analogs, G5-110s8, G5-112s5, and G5-114s5, bind to the ligand-free active form of TAAR1 faster than they bind to the inactive ligand-free form of TAAR1. The models do not suggest an upper limit on the binding rate of those 3 analogs to the ligand-free active form of TAAR1. A control assay lacking TAAR1 revealed an electrophysiological off-target effect caused by G5-109s8. Also, a novel synthetic route was developed for ET-92, the lead compound for this project, which reduced the number of synthetic steps from 14 to 5 and improved the overall yield from 15.3% to 18.3% (77.4 mg) with the hope that further improvements in yield are possible.
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Books on the topic "Pharmaceutical chemistry – Research"

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Colombo, Giulia P. Medicinal chemistry research progress. New York: Nova Science Publishers, 2008.

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Singh, Harkishan. Medicinal chemistry research in India. Lucknow: National Information Centre for Drugs and Pharmaceuticals, Central Drug Research Institute, 1985.

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Harkishan, Singh, Chawla A. S, Kapoor V. K, and National Information Centre for Drugs and Pharmaceuticals., eds. Medicinal chemistry research in India. Lucknow: National Information Centre for Drugs and Pharmaceuticals, 1985.

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Reitz, Allen B., Atta-ur Rahman, and M. Iqbal Choudhary. Frontiers in medicinal chemistry. Edited by ebrary Inc. Saif Zone, Sharjah, United Arab Emirates]: Bentham Science Publishers Ltd., 2010.

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M, Dembitsky Valery, and Abu Ali Hijazi, eds. Contemporary aspects of boron chemistry. Boston: Elsevier, 2005.

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Chemometrics applications and research: QSAR in medicinal chemistry. Toronto: Apple Academic Press, 2015.

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Ali, Hijazi Abu. Contemporary aspects of boron: Chemistry and biological applications. Amsterdam: Elsevier, 2005.

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Lipophilicity Symposium (2nd 2000 University of Lausanne). Pharmacokinetic optimization in drug research: Biological, physicochemical, and computational strategies. Zürich: Verlag Helvetica Chimica Acta, 2001.

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Schwartz, Harry. Breakthrough: The discovery of modern medicines at Janssen. Morris Plains, N.J: Skyline Pub. Group, 1989.

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Repič, Oljan. Principles of process research and chemical development in the pharmaceutical industry. New York: Wiley, 1998.

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Book chapters on the topic "Pharmaceutical chemistry – Research"

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Kawakubo, Hiromu. "Process Research with Explosive Reactions." In Pharmaceutical Process Chemistry, 363–80. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2010. http://dx.doi.org/10.1002/9783527633678.ch18.

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Karpf, Martin. "From Milligrams to Tons: The Importance of Synthesis and Process Research in the Development of New Drugs." In Pharmaceutical Process Chemistry, 1–37. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2010. http://dx.doi.org/10.1002/9783527633678.ch1.

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Patil, Sachinkumar, Shitalkumar Patil, Sudha Kharade, and Dipali Kamble. "Pharmaceutical Interactions in Drug Practices." In Handbook of Research on Medicinal Chemistry, 459–596. Toronto ; New Jersey : Apple Academic Press, 2017.: Apple Academic Press, 2017. http://dx.doi.org/10.1201/9781315207414-12.

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Sahu, Ram Kumar, and Amit Roy. "Pharmaceutical Importance of Natural Aphrodisiac Drugs." In Handbook of Research on Medicinal Chemistry, 163–97. Toronto ; New Jersey : Apple Academic Press, 2017.: Apple Academic Press, 2017. http://dx.doi.org/10.1201/9781315207414-5.

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Müller, Klaus. "Molecular Modelling and Structural Databases in Pharmaceutical Research." In Bioorganic Chemistry in Healthcare and Technology, 39–52. Boston, MA: Springer US, 1991. http://dx.doi.org/10.1007/978-1-4684-1354-0_4.

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Parasar, Parveen, and Vivek Singh. "Islet Transplantation in Type 1 Diabetes: Stem Cell Research and Therapy." In Medicinal Chemistry with Pharmaceutical Product Development, 33–57. Toronto ; New Jersey : Apple Academic Press, 2019. | Series: AAP research notes on chemistry: Apple Academic Press, 2019. http://dx.doi.org/10.1201/9780429487842-2.

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Heffron, Timothy P., Andrew McClory, and Andreas Stumpf. "The Discovery and Process Chemistry Development of GDC-0084, a Brain Penetrating Inhibitor of PI3K and mTOR." In Comprehensive Accounts of Pharmaceutical Research and Development: From Discovery to Late-Stage Process Development Volume 1, 147–73. Washington, DC: American Chemical Society, 2016. http://dx.doi.org/10.1021/bk-2016-1239.ch006.

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Zheng, Weifan, and Michael Jones. "Computers, Cheminformatics, and the Medicinal Chemist." In Computer Applications in Pharmaceutical Research and Development, 301–19. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2006. http://dx.doi.org/10.1002/0470037237.ch13.

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Duca, Gheorghe, and Veaceslav Boldescu. "Pharmaceuticals and Personal Care Products in the Environment." In The Role of Ecological Chemistry in Pollution Research and Sustainable Development, 27–35. Dordrecht: Springer Netherlands, 2009. http://dx.doi.org/10.1007/978-90-481-2903-4_3.

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Welch, John T. "Applications of Pentafluorosulfanyl Substitution in Life Sciences Research." In Fluorine in Pharmaceutical and Medicinal Chemistry, 175–207. IMPERIAL COLLEGE PRESS, 2012. http://dx.doi.org/10.1142/9781848166363_0006.

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Conference papers on the topic "Pharmaceutical chemistry – Research"

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Zhou, Jianbo, Xiaoying Cui, Chao Xu, Ming Zeng, and Wen Chen. "Preliminary Study Application on qParticipatoryq Teaching Mode in Pharmaceutical Organic Chemistry Experiment." In 2016 5th International Conference on Social Science, Education and Humanities Research. Paris, France: Atlantis Press, 2016. http://dx.doi.org/10.2991/ssehr-16.2016.175.

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Vázquez Álvarez, Ana María, and Gabriela Fernández Saavedra. "THE USE OF SIMULATORS IN THE TEACHING OF PHARMACOLOGY. STUDENTS' OPINION OF THE BACHELOR’S DEGREE IN CHEMISTRY PHARMACEUTICAL-BIOLOGIST." In 12th annual International Conference of Education, Research and Innovation. IATED, 2019. http://dx.doi.org/10.21125/iceri.2019.0421.

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Burlakovs, Juris, Jovita Pilecka, Inga Grinfelde, and Ruta Ozola-Davidane. "Clay minerals and humic substances as landfill closure covering material constituents: first studies." In Research for Rural Development 2020. Latvia University of Life Sciences and Technologies, 2020. http://dx.doi.org/10.22616/rrd.26.2020.032.

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Abstract:
Soil and groundwater as the leachate may contaminate surrounding watersheds, thus different pollutants from closed dumps and landfills pose significant risks to human health and ecology. Pollution may lead to soil and water degradation however it might be diminished through sustainable dump site closure projects and processual management. Several decades of clays and clay minerals studies lead to modified clay composites concept that is one of the potential promising solutions for building the landfill covering material and serve as capping biocover layer at the same time. As humic substances are constituents of soil organic matter, pollutants can be sorbed on the surfaces of complex molecules. This kind of humic acid-clay mineral composite materials thus might become as low cost building material component - covering material. Construction of such layer are to be performed as a combination of clay-humic composites and landfill mined fine fraction of waste with small amendment of natural soil. Several hypotheses that are already proven has to be mentioned: a) Clay minerals produce composites with humic substances; 2) Clay-humic complexes reduce through sorption both organic and inorganic pollutants; 3) Low risk of toxic byproducts from landfill mined waste fine fraction can be the problem; 4) Such composites mostly would trap toxic contaminants (e.g., pharmaceuticals) found in reworked fine fraction of waste. The aim of the work is to provide alternative solution for landfill closure by giving theoretical considerations from multidisciplinary knowledge of environmental engineering, chemistry and waste management.
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