Log in

Relevant bibliographies by topics / Pharmaceutical chemistry – Research / Journal articles

To see the other types of publications on this topic, follow the link: Pharmaceutical chemistry – Research.

Journal articles on the topic 'Pharmaceutical chemistry – Research'

Author: Grafiati

Published: 4 June 2021

Last updated: 11 February 2022

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Pharmaceutical chemistry – Research.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Dai, Qi Chang, Cui Ting Chen, Miao Yu, and Yu Bin Ji. "New Research on the Pharmaceutical Chemistry of Plant Polysaccharides." Applied Mechanics and Materials 411-414 (September 2013): 3237–41. http://dx.doi.org/10.4028/www.scientific.net/amm.411-414.3237.

Full text

Abstract:

The researches on plant polysaccharides develop rapidly in recent years. In this paper, the studies of pharmaceutical chemistry of polysaccharides from plants are reviewed. We introduce researches’ new progresses and results of the extraction, separation and purification in the field of pharmaceutical chemistry and expound the advantages and disadvantages of the applications of physical techniques, chemical technology and biotechnology. The applications of statistic principles in the field of medicinal chemistry are also discussed in this article.

APA, Harvard, Vancouver, ISO, and other styles

2

Saxena, Sanjai, Manmohan Chhibber, and Inder Pal Singh. "Fungal Bioactive Compounds in Pharmaceutical Research and Development." Current Bioactive Compounds 15, no. 2 (March 12, 2019): 211–31. http://dx.doi.org/10.2174/1573407214666180622104720.

Full text

Abstract:

Background:Exploration of antibiotics from microorganisms became widespread in the academia and the industry with the serendipitous discovery of Penicillin from Penicillium notatum by Sir Alexander Fleming. This embarked the golden era of antibiotics which lasted for over 60 years. However, the traditional phenotypic screening was replaced with more rational and smarter methods of exploration of bioactive compounds from fungi and microorganisms. Fungi have been responsible for providing a variety of bioactive compounds with diverse activities which have been developed into blockbuster drugs such as Cyclosporine, Caspofungin, Lovastatin and Fingolimod etc. It has been reported that ca. 40% of the 1453 New Chemical Entities (NCE’s) approved by USFDA are natural products, natural product inspired or mimics many of which have their origins from fungi. Hence fungal compounds are playing a very important role in drug discovery and development in the pharmaceutical industry.Methods:We undertook structured searches of bibliographic databases of peer-reviewed research literature which pertained to natural products, medicinal chemistry of natural products and drug discovery from fungi. With the strategic improvement in screening and identification methods, fungi are still a potential resource for novel chemistries. Thus the searches also comprised of bioactive agents from fungi isolated or derived from special ecological groups and lineages. To find different molecules derived or isolated from fungi under clinical studies, clinical trial data from the NIH as well as from pharmaceutical companies were also explored. This comprised of data wherein the pharmaceutical industries have acquired or licensed a fungal bioactive compound for clinical study or a trial.Results:Natural product chemistry and medicinal chemistry continue to play an important role in converting a bioactive compound into therapeutic moieties or pharmacophores for new drug development.Conclusion:Thus one can say fungal bioactive compounds are alive and well for development into new drugs as novel ecological groups of fungi as well as novel chemistries are being uncovered. This review further emphasizes the collaboration of fungal biologists with chemists, pharmacologists and biochemists towards the development of newer drugs for taking them into the drug development pipeline.

APA, Harvard, Vancouver, ISO, and other styles

3

Bajorath, Jürgen. "Computational chemistry in pharmaceutical research: at the crossroads." Journal of Computer-Aided Molecular Design 26, no. 1 (November 15, 2011): 11–12. http://dx.doi.org/10.1007/s10822-011-9488-z.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Pawson, Beverly A. "Medicinal Chemistry: The Role of Organic Chemistry in Drug Research." Journal of Pharmaceutical Sciences 75, no. 8 (August 1986): 828. http://dx.doi.org/10.1002/jps.2600750837.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Bryan, Marian C., Peter J. Dunn, David Entwistle, Fabrice Gallou, Stefan G. Koenig, John D. Hayler, Matthew R. Hickey, et al. "Key Green Chemistry research areas from a pharmaceutical manufacturers’ perspective revisited." Green Chemistry 20, no. 22 (2018): 5082–103. http://dx.doi.org/10.1039/c8gc01276h.

Full text

Abstract:

The ACS Green Chemistry Institute® Pharmaceutical Roundtable has assembled an updated list of key research areas to highlight transformations and reaction media where more sustainable technologies would be most impactful.

APA, Harvard, Vancouver, ISO, and other styles

6

Swaan, Peter W. "Pharmaceutical Research—Looking Ahead." Pharmaceutical Research 26, no. 3 (January 22, 2009): 491. http://dx.doi.org/10.1007/s11095-009-9836-z.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Nisiwaki, Masanori. "Green Chemistry in Process Research and Development in Pharmaceutical Industry." Journal of Synthetic Organic Chemistry, Japan 61, no. 5 (2003): 464–71. http://dx.doi.org/10.5059/yukigoseikyokaishi.61.464.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Campeau, Louis-Charles, and Deryn E. Fogg. "The Roles of Organometallic Chemistry in Pharmaceutical Research and Development." Organometallics 38, no. 1 (January 14, 2019): 1–2. http://dx.doi.org/10.1021/acs.organomet.8b00918.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Constable, David J. C., Peter J. Dunn, John D. Hayler, Guy R. Humphrey, Johnnie L. Leazer, Jr., Russell J. Linderman, Kurt Lorenz, et al. "Key green chemistry research areas—a perspective from pharmaceutical manufacturers." Green Chem. 9, no. 5 (2007): 411–20. http://dx.doi.org/10.1039/b703488c.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Lupascu, Naliana, Emin Cadar, Melat Cherim, Cristina Luiza Erimia, and Rodica Sîrbu. "Research Concerning the Efficiency of Aronia Melanocarpa for Pharmaceutical Purpos." European Journal of Interdisciplinary Studies 2, no. 1 (April 30, 2016): 115. http://dx.doi.org/10.26417/ejis.v2i1.p115-121.

Full text

Abstract:

The major impact of many types of disease on the human body have generated medical research orientation toward biotechnology identification and extraction of active principles from natural resources. The social problem to improve the health of the population, to maintain social balance of a healthy society oriented medical-pharmaceutical research for the use of other sources of pharmaceuticals from natural sources and not synthetic chemistry. On this line of work is also included the research wich orientates pharmaceutical medical studies by using new sources of bioactive compounds such as: anthocyanes, flavonoids, phenolic acids, chlorogenic acid, tannins, vitamin P,C, B2, B6 from the shrub Aronia Melanocarpa. Besides these compounds are also found in the fruits different cyanidin glycosides: 3-galactoside, 3-glucoside, 3-arabinoside and 3-xyloside. The rich content in bioactive forms makes possible the use in treating certain diseases by using internal use in household. For internal use are used by diabetics having hypoglycemic effect, astringent properties and very strong diuretics, they are cardiac tonic, regulates blood pressure and blood glucose, treatment of varicose veins and hemorrhoids, it has a good hepatoprotective effect due to its high iodine content , are effective in hyperthyroidism and can be consumed by sufferers of Alzheimer's disease and relieving symptoms slowig the aging processes.

APA, Harvard, Vancouver, ISO, and other styles

11

Lupascu, Naliana, Emin Cadar, Melat Cherim, Cristina Luiza Erimia, and Rodica Sîrbu. "Research Concerning the Efficiency of Aronia Melanocarpa for Pharmaceutical Purpos." European Journal of Interdisciplinary Studies 4, no. 1 (April 30, 2016): 115. http://dx.doi.org/10.26417/ejis.v4i1.p115-121.

Full text

Abstract:

The major impact of many types of disease on the human body have generated medical research orientation toward biotechnology identification and extraction of active principles from natural resources. The social problem to improve the health of the population, to maintain social balance of a healthy society oriented medical-pharmaceutical research for the use of other sources of pharmaceuticals from natural sources and not synthetic chemistry. On this line of work is also included the research wich orientates pharmaceutical medical studies by using new sources of bioactive compounds such as: anthocyanes, flavonoids, phenolic acids, chlorogenic acid, tannins, vitamin P,C, B2, B6 from the shrub Aronia Melanocarpa. Besides these compounds are also found in the fruits different cyanidin glycosides: 3-galactoside, 3-glucoside, 3-arabinoside and 3-xyloside. The rich content in bioactive forms makes possible the use in treating certain diseases by using internal use in household. For internal use are used by diabetics having hypoglycemic effect, astringent properties and very strong diuretics, they are cardiac tonic, regulates blood pressure and blood glucose, treatment of varicose veins and hemorrhoids, it has a good hepatoprotective effect due to its high iodine content , are effective in hyperthyroidism and can be consumed by sufferers of Alzheimer's disease and relieving symptoms slowig the aging processes.

APA, Harvard, Vancouver, ISO, and other styles

12

Braña, Miguel F., and Ana Sánchez-Migallón. "Anticancer drug discovery and pharmaceutical chemistry: a history." Clinical and Translational Oncology 8, no. 10 (October 2006): 717–28. http://dx.doi.org/10.1007/s12094-006-0118-5.

Full text

APA, Harvard, Vancouver, ISO, and other styles

13

Rajput, Dr Gurinder Singh. "Editorial." Asian Journal of Chemistry and Pharmaceutical Sciences 2, no. 1 (April 17, 2017): i. http://dx.doi.org/10.18311/ajcps/2017/15908.

Full text

Abstract:

I am pleased to present the Volume 2 Issue 1 of Asian Journal of Chemistry and Pharmaceutical Sciences. AJCPS is a quarterly peer-reviewed journal committed to publish the high quality articles in all area of chemistry and pharmaceutical science. Chemistry and Pharmaceutical science are closely related disciplines and their convergence is very frequent. In spite of excessive ongoing research in these disciplines very few journals, especially from Asian region are available those cover both the subjects. I hope that AJCPS will encourage the researchers, students and academicians involved in Chemistry and Pharmaceutical research.

APA, Harvard, Vancouver, ISO, and other styles

14

Berger, Gilles. "Pharmaceutical patent landscape for cancer immunotherapy: an interview with Gilles Berger." Pharmaceutical Patent Analyst 8, no. 5 (September 2019): 163–64. http://dx.doi.org/10.4155/ppa-2019-0021.

Full text

Abstract:

Dr Gilles Berger is a chemist and pharmacist with broad interest in organic and theoretical chemistry, drug discovery and design, biomedical sciences and oncology. He has worked as a Research Fellow in Brussels, Paris, Montreal and at MIT in Boston, where he has gathered hands-on experience at the interface of drug design, nanotechnologies, biology and human disease. He has been involved in project management and mentoring and has in depth experience in collaborative and multi-disciplinary projects, with a proven track record of publications in various fields, in collaboration with research groups from all around Europe, Canada and the US. In recent years, he has developed as a translational scientist, allowing the use of his complementary multi-disciplinary skills toward the advancement of fundamental projects, such as organocatalysis, theoretical chemistry or halogen bonding; as well as in applications like drug discovery, as evidenced by his numerous publications aimed at developing novel anticancer medicines and other agents. He is currently a Research Fellow of the Harvard Medical School, a Research Associate at MIT and a Fellow of the Belgian Science Foundation.

APA, Harvard, Vancouver, ISO, and other styles

15

Debue-Barazer, Christine. "Les implications scientifiques et industrielles du succès de la Stovaïne®. Ernest Fourneau (1872–1949) et la chimie des médicaments en France." Gesnerus 64, no. 1-2 (November 11, 2007): 24–53. http://dx.doi.org/10.1163/22977953-0640102002.

Full text

Abstract:

The synthetic local anaesthetic Stovaïne® was commercialised in France in 1904. Its inventor, Ernest Fourneau, began his career as a pharmaceutical chemist in organic chemistry laboratories in Germany, where from 1899 to 1901 he discovered how basic research could benefit from the modern chemistry theories which had developed in Germany starting in the 1860s. Using the complex structure of cocaine, he invented an original molecule, with comparable activity, but less toxic. The knowledge and the know-how which he acquired in Germany nourished his reflection in the field of the chemistry of the relationships between structure and activity, and led him to the development of Stovaïne®. Emile Roux, Director of the Pasteur Institute in Paris,was interested in his work and invited him to head the first French therapeutic chemistry laboratory, in which research on medicinal chemistry was organised scientifically. The industrial development of new medicines resulting from the Pasteur Institute’s therapeutic chemistry laboratory was supported by the Etablissements Poulenc frères, France thus gaining international reputation in the domain of pharmaceutical chemistry.

APA, Harvard, Vancouver, ISO, and other styles

16

Hann, Mike M., and Tudor I. Oprea. "Pursuing the leadlikeness concept in pharmaceutical research." Current Opinion in Chemical Biology 8, no. 3 (June 2004): 255–63. http://dx.doi.org/10.1016/j.cbpa.2004.04.003.

Full text

APA, Harvard, Vancouver, ISO, and other styles

17

Werz, Daniel B., and Peter H. Seeberger. "Carbohydrates as the Next Frontier in Pharmaceutical Research." Chemistry - A European Journal 11, no. 11 (May 20, 2005): 3194–206. http://dx.doi.org/10.1002/chem.200500025.

Full text

APA, Harvard, Vancouver, ISO, and other styles

18

Sutariya, Vijaykumar, Anastasia Groshev, Prabodh Sadana, Deepak Bhatia, and Yashwant Pathak. "Artificial Neural Network in Drug Delivery and Pharmaceutical Research." Open Bioinformatics Journal 7, no. 1 (December 13, 2013): 49–62. http://dx.doi.org/10.2174/1875036201307010049.

Full text

Abstract:

Artificial neural networks (ANNs) technology models the pattern recognition capabilities of the neural networks of the brain. Similarly to a single neuron in the brain, artificial neuron unit receives inputs from many external sources, processes them, and makes decisions. Interestingly, ANN simulates the biological nervous system and draws on analogues of adaptive biological neurons. ANNs do not require rigidly structured experimental designs and can map functions using historical or incomplete data, which makes them a powerful tool for simulation of various non-linear systems.ANNs have many applications in various fields, including engineering, psychology, medicinal chemistry and pharmaceutical research. Because of their capacity for making predictions, pattern recognition, and modeling, ANNs have been very useful in many aspects of pharmaceutical research including modeling of the brain neural network, analytical data analysis, drug modeling, protein structure and function, dosage optimization and manufacturing, pharmacokinetics and pharmacodynamics modeling, and in vitro in vivo correlations. This review discusses the applications of ANNs in drug delivery and pharmacological research.

APA, Harvard, Vancouver, ISO, and other styles

19

Rodríguez Cabrera, Hortensia M. "Emerging and inter/trans-disciplinary research areas related to Chemistry." Bionatura 5, no. 1 (February 15, 2020): 1021–22. http://dx.doi.org/10.21931/rb/2020.05.01.1.

Full text

Abstract:

Undoubtedly, Chemistry is a central science because it serves as a support and contributes to the development of many other disciplines, such as biology, geology, physics, paleontology, etc. Just by observing the environment that surrounds us, we can conclude that the world is composed of an infinite number of inert or living components, and all of them are composed of chemical substances of a broad range of complexity. On the other hand, Chemistry has a direct relationship with the economic development of a country, due to most industries are based on chemical processes or materials. The impact of chemistry in different activities is high, in construction, ceramics, and steel, in the food, Energy or Petrochemical industry, in textile design, in Cosmetics and fragrances, in Agrochemicals and fertilizers, Pharmaceutical products, Water treatment, in Companies specialized in Environmental Chemistry, Manufacture of plastics and rubbers, quality and safety processes, in the mining industry, and so forth.

APA, Harvard, Vancouver, ISO, and other styles

20

Singh, Pramod, Jitendra Singh, Geeta J. Pant, and Mohan S. M. Rawat. "2-Pyrazolines as Biologically Active and Fluorescent Agents, An Overview." Anti-Cancer Agents in Medicinal Chemistry 18, no. 10 (January 23, 2019): 1366–85. http://dx.doi.org/10.2174/1871520618666180313153407.

Full text

Abstract:

Nitrogen-containing five-membered heterocyclics play a vital role in pharmaceuticals as well as medicinal chemistry. Pyrazolines play a significant role among other heterocycles because of their therapeutic and pharmacological properties. 2-Pyrazolines displayed a wide variety of biological activities such as anticancer, antiepileptic, anti-aids, antimalarial, insecticidal, antitubercular, etc. and they are used as pesticides, herbicides, fungicides and also used in agrochemical research and analytical chemistry. 2-Pyrazolines are well-known brightening agents used in chemosensor. They have excellent fluorescent properties and are widely used in synthetic fibers, dyes, photography and hole transporting materials. A number of preparation methods of pyrazolines have also been investigated by several research groups. In this review, most of the synthesized and reported nitrogen-containing five-membered heterocycles including 2-pyrazolines, their pharmaceutical evaluation and structure-reactivity are discussed.

APA, Harvard, Vancouver, ISO, and other styles

21

Koudoro, Alain Y., Christian Tetede Rodrigue Konfo, Philippe Sessou, and Dominique C. K. Sohounhloue. "Status of research results in chemistry of biologically active substances in Benin." International Journal of Phytomedicine 10, no. 3 (November 19, 2018): 125. http://dx.doi.org/10.5138/09750185.2251.

Full text

Abstract:

Research on biologically active chemicals extracted from medicinal plants and essential oils from aromatic plants in the West African subregion is booming. Recognition of the clinical, pharmaceutical and economic value of herbal medicines continues to grow despite the growth of the pharmaceutical industry and the continued development of new, more effective synthetic and biological medical products. On the other hand, despite the improvement in food preservation technics, food preservatives nature remains one of the most important issues for public health. Indeed, several synthetic preservatives have been banned in some countries because of their long-term adverse toxicological effects. The current trend of consumers to seek for a more natural diet has prompted the research, development and application of new natural products with antimicrobial and antioxidant activities in order to use them as alternatives to synthetic preservatives. This review aims to do an inventory of the results of research in chemistry of biologically active substances in Benin.

APA, Harvard, Vancouver, ISO, and other styles

22

Hughes, H. A., and C. J. Mackson. "Centre for food and pharmaceutical packaging research." Packaging Technology and Science 1, no. 1 (January 1988): 44. http://dx.doi.org/10.1002/pts.2770010110.

Full text

APA, Harvard, Vancouver, ISO, and other styles

23

Pedro, Sónia N., Carmen S. R. Freire, Armando J. D. Silvestre, and Mara G. Freire. "The Role of Ionic Liquids in the Pharmaceutical Field: An Overview of Relevant Applications." International Journal of Molecular Sciences 21, no. 21 (November 5, 2020): 8298. http://dx.doi.org/10.3390/ijms21218298.

Full text

Abstract:

Solubility, bioavailability, permeation, polymorphism, and stability concerns associated to solid-state pharmaceuticals demand for effective solutions. To overcome some of these drawbacks, ionic liquids (ILs) have been investigated as solvents, reagents, and anti-solvents in the synthesis and crystallization of active pharmaceutical ingredients (APIs), as solvents, co-solvents and emulsifiers in drug formulations, as pharmaceuticals (API-ILs) aiming liquid therapeutics, and in the development and/or improvement of drug-delivery-based systems. The present review focuses on the use of ILs in the pharmaceutical field, covering their multiple applications from pharmaceutical synthesis to drug delivery. The most relevant research conducted up to date is presented and discussed, together with a critical analysis of the most significant IL-based strategies in order to improve the performance of therapeutics and drug delivery systems.

APA, Harvard, Vancouver, ISO, and other styles

24

Javoor, Manjunath, Pradip Mondal, and Deepak Chopra. "Cocrystals: A Review of Recent Trends in Pharmaceutical and Material Science Applications." Material Science Research India 14, no. 1 (June 17, 2017): 09–18. http://dx.doi.org/10.13005/msri/140103.

Full text

Abstract:

Over the last two decades, the design of multicomponent molecular crystals or cocrystals has grown out to be an interesting and promising area of research in pharmaceuticals and material science. Cocrystallization is at the interface of crystal engineering and supramolecular chemistry and allows us to vary the physicochemical properties of solids according to the need, through manipulation of various intermolecular interactions. In this short review, we focus on some recent reports on pharmaceutical cocrystals and emerging subclasses of cocrystals, namely: Charge transfer cocrystals, Energetic cocrystals, and Ternary cocrystals and discuss about their methods of characterization and applications of importance in the industry.

APA, Harvard, Vancouver, ISO, and other styles

25

Leuenberger, Hans. "Pharmaceutical Technology: Drug Delivery, Formulation, and Process Research." CHIMIA International Journal for Chemistry 60, no. 1 (February 23, 2006): 40–45. http://dx.doi.org/10.2533/000942906777675092.

Full text

APA, Harvard, Vancouver, ISO, and other styles

26

Gama, M. R., C. H. Collins, and C. B. G. Bottoli. "Nano-Liquid Chromatography in Pharmaceutical and Biomedical Research." Journal of Chromatographic Science 51, no. 7 (April 12, 2013): 694–703. http://dx.doi.org/10.1093/chromsci/bmt023.

Full text

APA, Harvard, Vancouver, ISO, and other styles

27

Sunkara, Manjula, and Martha J. M. Wells. "Phase II pharmaceutical metabolites acetaminophen glucuronide and acetaminophen sulfate in wastewater." Environmental Chemistry 7, no. 1 (2010): 111. http://dx.doi.org/10.1071/en09098.

Full text

Abstract:

Environmental context. Excretion of pharmaceuticals and their metabolites by humans and animals, flushing unused pharmaceuticals and inadequate water treatment result in the occurrence of these chemicals as pollutants in wastewater, surface water and drinking water. In this research, the pharmaceutical agent acetaminophen (paracetamol, Tylenol) and its glucuronide and sulfate metabolites were examined as a model system for monitoring wastewater influent and effluent. The true risk to ecosystems and humans from the occurrence of pharmaceuticals in our water supply can only be estimated if accurate concentrations of parent pharmaceutical chemicals as well as their metabolites are measured. Abstract. An analytical method was developed to separately determine acetaminophen and its Phase II metabolites, acetaminophen glucuronide and acetaminophen sulfate, from wastewater in a single extract. The method developed will serve as a model for screening for the presence of other non-steroidal pharmaceutical compounds and their Phase II metabolites in wastewater. Acetaminophen glucuronide was not present in the wastewater influent tested to verify the analytical protocol, whereas concentrations of acetaminophen and acetaminophen sulfate in the influent were reproducible over time. A Phase I metabolite, p-aminophenol, was also determined to occur in the wastewater influent. Concentrations of the analytes-of-interest, detected in effluent samples collected after secondary treatment, but before UV treatment, were highly variable and were undetectable after UV treatment before release to surface water.

APA, Harvard, Vancouver, ISO, and other styles

28

Corá, Luciana A., Madileine F. Américo, Ricardo B. Oliveira, Cristina H. R. Serra, Oswaldo Baffa, Raul C. Evangelista, Giselle F. Oliveira, and José Ricardo Aruda Miranda. "Biomagnetic Methods: Technologies Applied to Pharmaceutical Research." Pharmaceutical Research 28, no. 3 (October 15, 2010): 438–55. http://dx.doi.org/10.1007/s11095-010-0285-5.

Full text

APA, Harvard, Vancouver, ISO, and other styles

29

Yokota, Hiroyuki. "Applications of proteomics in pharmaceutical research and development." Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1867, no. 1 (January 2019): 17–21. http://dx.doi.org/10.1016/j.bbapap.2018.05.008.

Full text

APA, Harvard, Vancouver, ISO, and other styles

30

Berendt, Robert T., Diana M. Sperger, Eric J. Munson, and Paul K. Isbester. "Solid-state NMR spectroscopy in pharmaceutical research and analysis." TrAC Trends in Analytical Chemistry 25, no. 10 (November 2006): 977–84. http://dx.doi.org/10.1016/j.trac.2006.07.006.

Full text

APA, Harvard, Vancouver, ISO, and other styles

31

Veale, Clinton G. L., Rui W. M. Krause, and Joyce D. Sewry. "Blending problem-based learning and peer-led team learning, in an open ended ‘home-grown’ pharmaceutical chemistry case study." Chemistry Education Research and Practice 19, no. 1 (2018): 68–79. http://dx.doi.org/10.1039/c7rp00180k.

Full text

Abstract:

Pharmaceutical chemistry, medicinal chemistry and the drug discovery process require experienced practitioners to employ reasoned speculation in generating creative ideas, which can be used to evolve promising molecules into drugs. The ever-evolving world of pharmaceutical chemistry requires university curricula that prepare graduates for their role as designers with the capability of applying complex concepts in pharmaceutical chemistry, thereby improving the decision-making process. Common methods of teaching drug discovery, including the linear nature of the traditional case study model, do not provide a realistic picture of the underlying complexity of the process, nor do they equip students with the appropriate tools for personal sense making and abstraction. In this work, we discuss the creation of an open-ended, nonlinear case study for 3rd year pharmaceutical chemistry students, developed from drug discovery research conducted at Rhodes University. Furthermore, we discuss blending problem based learning (PBL) with peer-led team learning (PLTL) in the context of curriculum transformation, underpinned by the theory of semantic waves, to assist students in the early attainment of abstract concepts and answer questions of contextualisation, personal sense making, relatability, relevance and ultimately the skills for lifelong learning.

APA, Harvard, Vancouver, ISO, and other styles

32

Welch, Christopher J. "Microscale chiral HPLC in support of pharmaceutical process research." Chirality 21, no. 1 (January 2009): 114–18. http://dx.doi.org/10.1002/chir.20625.

Full text

APA, Harvard, Vancouver, ISO, and other styles

33

Duchstein, Hans-Juergen, Sabine Riederer, and Christin Erbach. "ChemInform Abstract: Active Nitrogen Species: A Novel Field of Research for the Pharmaceutical Chemistry." ChemInform 30, no. 41 (June 13, 2010): no. http://dx.doi.org/10.1002/chin.199941304.

Full text

APA, Harvard, Vancouver, ISO, and other styles

34

Awad, Laila Fathy, and Mohammed Salah Ayoup. "Fluorinated phenylalanines: synthesis and pharmaceutical applications." Beilstein Journal of Organic Chemistry 16 (May 15, 2020): 1022–50. http://dx.doi.org/10.3762/bjoc.16.91.

Full text

Abstract:

Recent advances in the chemistry of peptides containing fluorinated phenylalanines (Phe) represents a hot topic in drug research over the last few decades. ᴅ- or ʟ-fluorinated phenylalanines have had considerable industrial and pharmaceutical applications and they have been expanded also to play an important role as potential enzyme inhibitors as well as therapeutic agents and topography imaging of tumor ecosystems using PET. Incorporation of fluorinated aromatic amino acids into proteins increases their catabolic stability especially in therapeutic proteins and peptide-based vaccines. This review seeks to summarize the different synthetic approaches in the literature to prepare ᴅ- or ʟ-fluorinated phenylalanines and their pharmaceutical applications with a focus on published synthetic methods that introduce fluorine into the phenyl, the β-carbon or the α-carbon of ᴅ-or ʟ-phenylalanines.

APA, Harvard, Vancouver, ISO, and other styles

35

Funasaki, Noriaki, Seiji Ishikawa, and Saburo Neya. "Advances in physical chemistry and pharmaceutical applications of cyclodextrins." Pure and Applied Chemistry 80, no. 7 (January 1, 2008): 1511–24. http://dx.doi.org/10.1351/pac200880071511.

Full text

Abstract:

Cyclodextrins (CDs) attract much attention for industrial applications and academic research. A few experimental methods for determination of the binding constant between CD and a guest molecule were reviewed critically. A hydrophile–hydrophobe matching model for host–guest docking was proposed for estimation of the binding constant and the solution structure of the complex. Rather detailed solution structures of CD complexes were determined by proton NMR spectroscopy, aided by calculations of molecular mechanics and surface areas, and were used to analyze the binding constants. The binding constants of CDs with multi-site guests were analyzed on the basis of their solution structures. The working mechanisms and physicochemical predictions in a few pharmaceutical applications of CDs were proposed on the basis of detailed solution structures and accurate binding constants.

APA, Harvard, Vancouver, ISO, and other styles

36

Jansson, Sven Olof, and J�rgen Vessman. "Trends in product analysis for research in the pharmaceutical industry." Mikrochimica Acta 104, no. 1-6 (January 1991): 103–12. http://dx.doi.org/10.1007/bf01245501.

Full text

APA, Harvard, Vancouver, ISO, and other styles

37

Welch, Christopher J., Jennifer Albaneze-Walker, William R. Leonard, Mirlinda Biba, Jimmy DaSilva, Derek Henderson, Brian Laing, et al. "Adsorbent Screening for Metal Impurity Removal in Pharmaceutical Process Research." Organic Process Research & Development 9, no. 2 (March 2005): 198–205. http://dx.doi.org/10.1021/op049764f.

Full text

APA, Harvard, Vancouver, ISO, and other styles

38

Niculet, Elena, Gina Vica Neculia, Alin Laurentiu Tatu, and Olimpia Dumitriu Buzia. "Curcumin- Extraction, Physical and Chemical Analysis, Formulas and Control. Basic Methods for Further Research." Materiale Plastice 55, no. 4 (December 30, 2018): 672–75. http://dx.doi.org/10.37358/mp.18.4.5110.

Full text

Abstract:

Turmeric, with its active component curcumin has been regarded lately as an important potential therapeutic agent due to its properties and many uses. Further research needs to be done both on animals and humans in order for it to be used at a large scale. As curcumin gets absorbed better through topical and not oral administration, curcumin-based pharmaceuticals with skin passage must be devised. In order for this to be done, the need for a standardized, verified and simple extraction method and one for ointment preparation with stability in time rises. We propose in this study a method for curcumin extraction, one that ensures an adequate stability in time and a method for pharmaceutical control.

APA, Harvard, Vancouver, ISO, and other styles

39

Ekins, Sean, and Antony J. Williams. "Reaching Out to Collaborators: Crowdsourcing for Pharmaceutical Research." Pharmaceutical Research 27, no. 3 (January 27, 2010): 393–95. http://dx.doi.org/10.1007/s11095-010-0059-0.

Full text

APA, Harvard, Vancouver, ISO, and other styles

40

Ekins, Sean. "The Next Era: Deep Learning in Pharmaceutical Research." Pharmaceutical Research 33, no. 11 (September 6, 2016): 2594–603. http://dx.doi.org/10.1007/s11095-016-2029-7.

Full text

APA, Harvard, Vancouver, ISO, and other styles

41

Soudijn, W. "Research in the division of medicinal chemistry." Pharmaceutisch Weekblad Scientific Edition 7, no. 2 (April 1985): 71–74. http://dx.doi.org/10.1007/bf02106131.

Full text

APA, Harvard, Vancouver, ISO, and other styles

42

Tjaden, U. R. "Research in the division of analytical chemistry." Pharmaceutisch Weekblad Scientific Edition 7, no. 2 (April 1985): 75–78. http://dx.doi.org/10.1007/bf02106132.

Full text

APA, Harvard, Vancouver, ISO, and other styles

43

Koymans, Luc M. H. "Computational chemistry in biotransformational and toxicological research." Pharmacy World & Science 15, no. 2 (March 1993): 86–88. http://dx.doi.org/10.1007/bf01874089.

Full text

APA, Harvard, Vancouver, ISO, and other styles

44

Lee, Jang Yun, and John F. DeBernardis. "A perspective on pharmaceutical industrial research on antihypertensive drugs." Archives of Pharmacal Research 10, no. 4 (December 1987): 245–49. http://dx.doi.org/10.1007/bf02857748.

Full text

APA, Harvard, Vancouver, ISO, and other styles

45

Paradkar, Anant. "Crystal engineering for career opportunities in pharmaceutical research innovation." Acta Crystallographica Section A Foundations and Advances 73, a2 (December 1, 2017): C1110. http://dx.doi.org/10.1107/s2053273317084649.

Full text

APA, Harvard, Vancouver, ISO, and other styles

46

Jack, David, and Tom Walker. "Benjamin Arthur Hems. 29 June 1912—2 July 1995." Biographical Memoirs of Fellows of the Royal Society 43 (January 1997): 217–33. http://dx.doi.org/10.1098/rsbm.1997.0012.

Full text

Abstract:

Arthur Hems was best known as the Director of Chemistry and Research in the Glaxo Group who created the exceptional team of chemists who produced, inter alia, the first commercial synthetic thyroxine, numerous glucocorticoid steroids for systemic and topical use, and important cephalosporin antibiotics. Their expertise was a very significant part of the scientific base which enabled Glaxo Laboratories Limited, a relatively small British pharmaceutical company when he joined them in 1937, to grow into the truly international Glaxo-Wellcome pic of today.

APA, Harvard, Vancouver, ISO, and other styles

47

Testa, Bernard. "Pharmaceutical Sciences, Scientist, and Journals?A Tribute to Pharmaceutical Research for Its Coming of Age." Pharmaceutical Research 22, no. 2 (February 2005): 173–74. http://dx.doi.org/10.1007/s11095-004-1182-6.

Full text

APA, Harvard, Vancouver, ISO, and other styles

48

Bruni, Renato, Davide Barreca, Michele Protti, Virginia Brighenti, Laura Righetti, Lisa Anceschi, Laura Mercolini, Stefania Benvenuti, Giuseppe Gattuso, and Federica Pellati. "Botanical Sources, Chemistry, Analysis, and Biological Activity of Furanocoumarins of Pharmaceutical Interest." Molecules 24, no. 11 (June 8, 2019): 2163. http://dx.doi.org/10.3390/molecules24112163.

Full text

Abstract:

The aim of this work is to provide a critical review of plant furanocoumarins from different points of view, including their chemistry and biosynthetic pathways to their extraction, analysis, and synthesis, to the main biological activities found for these active compounds, in order to highlight their potential within pharmaceutical science. The limits and the possible improvements needed for research involving these molecules are also highlighted and discussed.

APA, Harvard, Vancouver, ISO, and other styles

49

Veleva, Vesela, and Berkeley W. Cue Jr. "Benchmarking green chemistry adoption by “big pharma” and generics manufacturers." Benchmarking: An International Journal 24, no. 5 (July 3, 2017): 1414–36. http://dx.doi.org/10.1108/bij-01-2016-0003.

Full text

Abstract:

Purpose The purpose of this paper is to benchmark current adoption of green chemistry (GC) practices by the innovative and generic pharmaceutical companies and examine the drivers, barriers and future opportunities. Design/methodology/approach The authors examined publicly available data for the top 10 “big pharma” and top ten generic drug manufacturers. Using the IQ Green Chemistry working group framework for effective GC programs, they scored each of the 20 companies in seven key areas. Findings The study finds that generic drug companies have not embraced GC at the level of the innovative pharmaceutical companies (average GC score of 2 vs 11 for “big pharma”). Top two barriers for them include: lack of pressure and incentives, and the burdensome regulatory process for making changes in the manufacturing process. Research limitations/implications The research is based on publicly disclosed information. It is possible that some generic drug manufacturers have begun to work internally on GC but have not disclosed externally yet. Future research should include a survey or interviews of generic drug manufacturers. Practical implications The company-level analysis, benchmarking framework and results are of value for researchers and practitioners interested in advancing greater adoption of GC by the pharmaceutical industry. Originality/value This study provides the first company-level benchmarking of GC adoption by the largest innovative and generics drug manufacturers. It contributes to the literature on the barriers and drivers for greater adoption of GC.

APA, Harvard, Vancouver, ISO, and other styles

50

Kahlert, Jan, Christopher J. D. Austin, Michael Kassiou, and Louis M. Rendina. "The Fifth Element in Drug Design: Boron in Medicinal Chemistry." Australian Journal of Chemistry 66, no. 10 (2013): 1118. http://dx.doi.org/10.1071/ch13256.

Full text

Abstract:

The unique chemistry of boron allows for the utilisation of novel building-blocks which are not traditionally found in medicinal chemistry. The pharmaceutical industry has begun to exploit boronic acid derivatives as new drugs and several research groups are also exploring 1,2-azaborines and icosahedral boranes known as carboranes as boron-based structural motifs, with great promise for innovative drug design. Recent advances in the medicinal chemistry of these three important boron moieties are highlighted and illustrated with selected examples.

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!