Relevant bibliographies by topics / Pharmaceutical cocrystals

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  1. Dissertations / Theses

Academic literature on the topic 'Pharmaceutical cocrystals'

Author: Grafiati
Published: 4 June 2021
Last updated: 10 March 2023

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Dissertations / Theses on the topic "Pharmaceutical cocrystals"

1

Mukherjee, Sreya. "Crystal Engineering of Pharmaceutical Cocrystals." Scholar Commons, 2011. http://scholarcommons.usf.edu/etd/3258.

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Pharmaceutical cocrystals use principles of crystal engineering for the design of crystalline forms of drugs and can improve their solubility, bioavailability, stability and other important properties without changing the efficacy of the drug. Herein reported are pharmaceutical cocrystals of two API's, caffeine and Pentoxifylline. Research has indicated that caffeine has the ability to reverse AB; plaque deposition in the brain (believed to be the primary cause of Alzheimer's pathogenesis) and thus revert memory and improve cognitive impairment. But owing to the fast absorption rate and short
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2

Karki, Shyam. "Pharmaceutical cocrystals : preparation and properties." Thesis, University of Cambridge, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.611636.

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3

Zu, Hui. "Mass transport of pharmaceutical cocrystals." Diss., University of Iowa, 2017. https://ir.uiowa.edu/etd/6023.

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Cocrystals have two or more neutral components (drug and cocrystal former) in the same crystal lattice which are held together via non-covalent bonds. Since the presence of the cocrystal former alters the energy of the drug molecules and their physicochemical properties, the drug dissolution characteristics can be manipulated by cocrystallization. A diffusion-convection-reaction (DCR) model has been developed to predict cocrystal intrinsic dissolution rates from the rotating disk system. In this work, the DCR model was used to further analyze the dissolution characteristics of 1:1 and 2:1 cocr
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4

CVETKOVSKI, Aleksandar. "Molecular cocrystals of pharmaceutical interest." Doctoral thesis, Università degli studi di Ferrara, 2015. http://hdl.handle.net/11392/2389116.

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Crystal form (cocrystals, polymorphs, salts, hydrates and solvates) assortment remains a scientific challenge that implicates practical issues in the pharmaceutical industry at the late stage of drug development of pharmaceutical formulations and in early stage of synthesis and isolation of an API in favorable defined crystalline form. Indeed, the selection of the optimal crystal form of an API that indisputably impacts the drug development program is directly related to the API’s aqueous solubility. Since the aqueous solubility of an API is the benchmark for its drug delivery and absorption
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5

Dabros, Marta. "Pharmaceutical Polymorphs, Cocrystals and Solid Solutions." Digital WPI, 2009. https://digitalcommons.wpi.edu/etd-dissertations/30.

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6

Trask, Andrew Vincent. "Pharmaceutical cocrystals : design, synthesis and analysis." Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.613783.

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7

Lange, Linda [Verfasser]. "Phase Behavior of Pharmaceutical Cocrystals / Linda Lange." München : Verlag Dr. Hut, 2017. http://d-nb.info/1126296147/34.

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8

Issa, N. "Towards more efficient screening of pharmaceutical cocrystals." Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1333228/.

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Pharmaceutical cocrystals are formed between active pharmaceutical ingredients (APIs) and coformers that are biologically safe. Cocrystals are of considerable relevance to the pharmaceutical industry as they offer the ability of optimizing the physical properties of an API whilst retaining its biological function. However, producing cocrystals is experimentally challenging and often results in undesired forms. The objective of work presented herein is to investigate a more effective screening approach. Assuming that the formation of cocrystals is thermodynamically driven, we tested whether a c
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9

Patel, Bhavnita. "Pharmaceutical co-amorphous materials and cocrystals : preparation and analysis." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648098.

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10

Tomaszewska, Irena. "In vitro and physiologically based pharmacokinetic models for pharmaceutical cocrystals." Thesis, University of Bath, 2013. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.607145.

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About 30% of commercial and developmental drugs exhibit poor solubility and thus poor bioavailability. Strategies that enhance solubility of such compounds have become more popular. Cocrystallisation is one of these strategies, so characterisation of in vitro performance of cocrystals is essential. Conventional dissolution systems (USP apparatus 1 and USP apparatus 2) are often not suitable for testing poorly soluble drugs due to failure in providing sink conditions and inability to change the media during the experiment. This project involves designing appropriate dissolution methods that wil
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