Academic literature on the topic 'Pharmaceutical excipient'

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Journal articles on the topic "Pharmaceutical excipient"

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Hamid, Junaid Ul, and Sunil Gupta. "Prediction of excipient-excipient incompatibility: A latent threat to pharmaceutical product development." Pharmaspire 14, no. 02 (2022): 65–75. http://dx.doi.org/10.56933/pharmaspire.2022.14208.

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The importance of pharmaceutical excipients in the creation of any dosage form is critical. These excipients are occasionally to blame for product underperformance and dosage form deterioration. Product deterioration and underperformance could be attributed to incompatibilities between drug and excipient or sometimes excipient and excipient either due to the presence of reactive impurities in the excipients or a reaction between the functional groups present on the excipients. Although the drug and excipient incompatibilities are monitored and reported, excipient-excipient incompatibilities ar
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Zhang, Haosheng. "Integration and Challenges of Excipients with Pharmacological Efficacy." Highlights in Science, Engineering and Technology 66 (September 20, 2023): 258–66. http://dx.doi.org/10.54097/hset.v66i.11712.

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Excipients are extra compounds that are included with the primary active ingredients in medicinal products. They are essential in enhancing the stability and accessibility of medications. Although excipients are a common component of daily life, incorporating them with pharmaceuticals still offers some difficulties. Although there are many different kinds of excipients, not all of them can completely match a medicine. Excipients will be used in diverse ways as carriers as a result of the various pharmaceutical production methods, which will modify the excipients that are chosen. Excipients oft
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Turek, Marika, Ewa Różycka-Sokołowska, Marek Koprowski, Bernard Marciniak, and Piotr Bałczewski. "Can Pharmaceutical Excipients Threaten the Aquatic Environment? A Risk Assessment Based on the Microtox® Biotest." Molecules 28, no. 18 (2023): 6590. http://dx.doi.org/10.3390/molecules28186590.

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The ecotoxicological impact of pharmaceuticals has received considerable attention, primarily focusing on active pharmaceutical ingredients (APIs) while largely neglecting the potential hazards posed by pharmaceutical excipients. Therefore, we analyzed the ecotoxicity of 16 commonly used pharmaceutical excipients, as well as 26 API–excipient and excipient–excipient mixtures utilizing the Microtox® test. In this way, we assessed the potential risks that pharmaceutical excipients, generally considered safe, might pose to the aquatic environment. We investigated both their individual ecotoxicity
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Bin, Liew Kai, Anand Gaurav, and Uttam Kumar Mandal. "A REVIEW ON CO-PROCESSED EXCIPIENTS: CURRENT AND FUTURE TREND OF EXCIPIENT TECHNOLOGY." International Journal of Pharmacy and Pharmaceutical Sciences 11, no. 1 (2019): 1. http://dx.doi.org/10.22159/ijpps.2019v11i1.29265.

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There is no single-component excipient fulfills all the requisite performance to allow an active pharmaceutical ingredient to be formulated into a specific dosage form. Co-processed excipient has received much more attention in the formulation development of various dosage forms, specially for tablet preparation by direct compression method. The objective of this review is to discuss the emergence of co-processed excipients as a current and future trend of excipient technology in pharmaceutical manufacturing. Co-processing is a novel concept of combining two or more excipients that possess spe
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Hamid, Junaid Ul, and Sunil Gupta. "Development and validation of a system for the prediction of excipient-excipient incompatibility using machine learning tools." Pharmaspire 14, no. 01 (2022): 18–27. http://dx.doi.org/10.56933/pharmaspire.2022.14103.

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The importance of pharmaceutical excipients in the creation of any dosage form is critical. These excipients are occasionally to blame for product underperformance and dosage form deterioration. Product deterioration and underperformance could be attributed to incompatibilities between drug and excipient or sometimes excipient and excipient either due to the presence of reactive impurities in the excipients or a reaction between the functional groups present on the excipients. Although, the drug and excipient incompatibilities are monitored and reported, excipient-excipient incompatibilities a
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Pragati, Kaloge* Tanuja Kad Romil Kale Rupali Kaloge Yashpal More. "Recent Advancements in Co-Processed Excipients." International Journal of Pharmaceutical Sciences 3, no. 1 (2025): 1489–97. https://doi.org/10.5281/zenodo.14688740.

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The primary objective of this review article aims to offer a thorough analysis among the most current advancements in excipient technology and its formulation techniques. It's impossible for one excipient to meet every performance requirement required to transform a drug's active component into a particular pharmaceutical formulation. The development of different dosage forms, particularly in the direct compression method of tablet production, has generated a lot of interest in Concurrently processed excipients. The purpose of this research is to investigate how co-processed excipients have be
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Prashant, Ghayal* Hanumant Gutte Adarsh Mane Bhushan Kolekar Prashant Bhoir. "The Impact of Excipients on Pharmaceutical Product Quality: Review the role of excipients in pharmaceutical product quality." International Journal of Pharmaceutical Sciences 3, no. 2 (2025): 1084–99. https://doi.org/10.5281/zenodo.14871326.

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However, it's important to mention that excipients play an important role in deciding the quality, safety, and efficacy of pharmaceutical products with their inactive inclusion as part of the formulation. Though inactive, excipients affect the stability, bioavailability, and patient acceptance of pharmaceuticals for use. In general, the present review article will provide insight into qualities introduced by excipients in pharmaceutical products, incorporating aspects on stability, bioavailability, and patient safety.The selection of excipients can have influence on the physical and chemical s
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Rajveer, Bhaskar Monika Ola Diksha Pingale* Rahul Patil Shailesh Chalikwar. "ROLE OF EXCIPIENT IN NANO-SUSPENSION." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES o6, no. 03 (2019): 6645–58. https://doi.org/10.5281/zenodo.2605501.

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<em>Excipients play an important role in formulate a dosage form. These are the ingredients which along with Active Pharmaceutical ingredients build up the dosage forms. Excipients act as suspending agents, stabilizing agents and can also be used to improve bioavailability of drugs in some instances, the following review discuss the different types and sources of excipients along with their uses, role and these can be used for different activities. Specific excipients are best suitable for a exacting dosage form; the selection criterion for excipients and various interactions that an excipient
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T V, Gaganashree, Balamuralidhara V, and Nikitha V. "A Global Comprehensive Review on Pharmaceutical Excipients." International Journal of Pharmaceutical Sciences and Nanotechnology(IJPSN) 18, no. 1 (2025): 7871–78. https://doi.org/10.37285/ijpsn.2025.18.1.14.

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An excipient is a substance intentionally added to a medication for purposes other than its therapeutic or diagnostic effects at the prescribed dosage. Excipients are essential for ensuring proper consistency, controlling the solubility and bioavailability of active ingredients, and enhancing the stability of active components in the final dosage form. In many developed countries, excipients are regulated similarly to active pharmaceutical ingredients, and in Europe, innovative excipients are evaluated as new chemical entities. Excipients are evaluated and approved for use as part of new pharm
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Mohammed, Boma B., Adamu B. Isah, Teryilla S. Allagh, and Philip F. Builders. "Effects of a co-processed novel multifunctional excipient on the tablet properties of metronidazole." Journal of Science and Practice of Pharmacy 6, no. 1 (2019): 316–23. http://dx.doi.org/10.47227/jsppharm.v6i1.6.

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Purpose: The objective of this work was to formulate and determine the effects of a co-processed novel, multifunctional pharmaceutical excipient on tablet parameters of metronidazole tablets produced by direct compression. Methods: The excipient was prepared by co-processing lactose, mucin and gelatin in a ratio of 90:1:9, dried and pulverized into powder using the co-fusion method. The excipient formulated was characterized using Differential scanning calorimetry (DSC) and Fourier transform infra-red spectroscopy (FTIR). The excipient was used to prepare metronidazole tablets and compared wit
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Dissertations / Theses on the topic "Pharmaceutical excipient"

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Nep, E. I. "Grewia polysaccharide gum as a pharmaceutical excipient." Thesis, Aston University, 2010. http://publications.aston.ac.uk/10310/.

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Grewia gum is obtained from the inner stem bark of the edible plant Grewia mollis Juss (Fam. Tiliaceae) which grows widely in the middle belt region of Nigeria, and is also cultivated. The dried and pulverised inner stem bark is used as a thickening agent in some food delicacies in that region of the country. This ability of the material to increase solution viscosity has generated a lot of interest and is the catalysing momentum for this research. Such materials have been used as stabilizers or suspending agents in cosmetics, foods and liquid medications, and as mucoadhesives and controlled r
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Mackin, L. A. "The effects of moisture on triboelectrification of selected pharmaceutical excipient powders." Thesis, University of Sunderland, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.245985.

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The literature contains conflicting reports on the effect of moisture on triboelectrification, indeed experiments have shown moisture to increase, decrease or have no effect at all on the charging of solids. The research programme investigated the role of moisture in the triboelectrification of a range of pharmaceutical excipients. Selection of excipients was made on the basis of a) moisture sorption capacity (the starch group) and b) potential use in dry powder inhaler formulations (the sugar and sorbitol group). The following excipients were selected for preliminary investigations:- a-lactos
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Camargo, Jhon Jairo Rojas. "Assessment of co-processing of cellulose II and silicon dioxide as a platform to enhance excipient functionality." Diss., University of Iowa, 2011. https://ir.uiowa.edu/etd/2763.

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This thesis project studied microcrystalline cellulose II (CII), a polymorphic form of cellulose, which has lower mechanical properties, less plastic deformation, higher elastic recovery and faster disintegration properties than microcrystalline cellulose I (CI). Also, the effects of processing and silicification on CII materials were investigated. Particle modification through spray drying, wet granulation and spheronization was employed to improve CII performance. Spray-drying (SDCII) and wet granulation (WGCII) produced materials with no difference in mechanical or disintegration properties
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Tant, Martin Ray. "Biopharmaceutic and Pharmacokinetic Studies of Sucrose Acetate Isobutyrate as an Excipient for Oral Drug Delivery." Digital Commons @ East Tennessee State University, 2011. https://dc.etsu.edu/etd/1345.

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Sucrose acetate isobutyrate (SAIB), a randomly substituted sucrose approximating sucrose diacetate hexaisobutyrate, is produced by Eastman Chemical Company for a variety of applications. SAIB is widely used in the food industry as a weighting agent to disperse flavoring oils in primarily citrus-based soft drink beverages. Additionally, SAIB is currently being marketed by another company as a parenteral drug delivery system. The studies reported here focused on investigating SAIB as an excipient, or delivery vehicle, for use in oral delivery of several drugs, including ibuprofen, saquinavir, an
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Tinmanee, Radaduen. "The role of pharmaceutical excipients in the solid-state degradation of Gabapentin." Diss., University of Iowa, 2015. https://ir.uiowa.edu/etd/1919.

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Drug instability in solid dosage forms includes chemical or physical processes involving covalent or polymorphic transformations wherein different polymorphs possess crystal structure differences. Gabapentin chemically degrades by intramolecular cyclization to gabapentin-lactam (lactam) in the solid-state. Additionally, gabapentin undergoes polymorphic solid-state transformations. A kinetic model was developed to describe the environmental and excipient effects on chemical and physical instability associated with milling induced stress and subsequent storage under controlled temperature and hu
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Gupta, Patel Salin. "MECHANISMS AND THERMODYNAMICS OF THE INFLUENCE OF SOLUTION-STATE INTERACTIONS BETWEEN HPMC AND SURFACTANTS ON MIXED ADSORPTION ONTO MODEL NANOPARTICLES." UKnowledge, 2019. https://uknowledge.uky.edu/pharmacy_etds/103.

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Nanoparticulate drug delivery systems (NDDS) such as nanocrystals, nanosuspensions, solid-lipid nanoparticles often formulated for the bioavailability enhancement of poorly soluble drug candidates are stabilized by a mixture of excipients including surfactants and polymers. Most literature studies have focused on the interaction of excipients with the NDDS surfaces while ignoring the interaction of excipients in solution and the extent to which the solution-state interactions influence the affinity and capacity of adsorption. Mechanisms by which excipients stabilize NDDS and how this informati
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El, Sanadi Caroline Elizabeth. "THE VALUE OF A FUNCTIONAL EXCIPIENT ADDITIVE TO HUMAN INSULIN THERAPIES: FROM MANUFACTURE TO HUMAN CLINICAL TRIAL." Case Western Reserve University School of Graduate Studies / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=case1450286879.

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Elgaied-Lamouchi, Dhouha. "Découverte de nouveaux excipients pharmaceutiques à base d'amidons modifiés pour une libération prolongée d'une substance active." Thesis, Lille, 2020. https://pepite-depot.univ-lille.fr/.

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Les comprimés matriciels hydrophiles sont fréquemment utilisés pour contrôler la libération d’actif dans les formes galéniques à usage oral. Les amidons représentent un choix intéressant pour cette application. En effet, ce sont des matériaux biocompatibles, biodégradables et disponibles à partir de différentes sources végétales. En plus des amidons natifs, les amidons modifiés (AM) ont été beaucoup étudiés pour la formulation des comprimés matriciels à libération prolongée. Les modifications physico-chimiques peuvent être ajustées de manière à correspondre aux propriétés souhaitées pour une a
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Velásquez, Armijo Cristián Jesús. "Aplicação de métodos termo-analíticos e espectroscóspicos na avaliação do comportamento do fármaco isoniazida frente a adjuvantes tecnológicos." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2003. http://hdl.handle.net/10183/144233.

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Os métodos termo-analíticos são ferramentas úteis na avaliação da compatibilidade entre fármacos e adjuvantes, com destaque à calorimetria exploratória diferencial. Neste trabalho foram avaliados a compatibilidade e o comportamento térmico entre a isoniazida e adjuvantes tecnológicos primários usualmente empregados em formas farmacêuticas sólidas. A compatibilidade foi examinada por meio da preparação de misturas físicas binárias do tipo fármaco/adjuvante. Foi investigada também a influência da granulação por via úmida e do processo de compactação para as misturas de isoniazida e adjuvantes co
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Mansa, Rola. "Preparation and Characterization of Novel Montmorillonite Nanocomposites." Thèse, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/20207.

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Clay minerals have historically played a consequential role in human health. While the beginnings were rooted in geophagy, a primitive act of consuming earth, the health-related uses of clay minerals have evolved and diversified over time. As excipients in pharmaceutical formulations, clay minerals can attribute novel properties onto intercalated compounds. Intercalating oxybenzone, a UV filter, within the interlamellar space of montmorillonite is desirable in order to minimize direct contact with skin. Intercalating resveratrol, a compound known for attributing beneficial effects onto hum
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Books on the topic "Pharmaceutical excipient"

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Koo, Otilia M. Y., ed. Pharmaceutical Excipients. John Wiley & Sons, Inc., 2016. http://dx.doi.org/10.1002/9781118992432.

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C, Rowe Raymond, Sheskey Paul J, Owen Siân C, and American Pharmacists Association, eds. Handbook of pharmaceutical excipients. 5th ed. Pharmaceutical Press, 2006.

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Sciences, Academy of Pharmaceutical, and Pharmaceutical Society of Great Britain., eds. Handbook of pharmaceutical excipients. American Pharmaceutical Association, 1986.

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Ainley, Wade, Weller Paul J, Academy of Pharmaceutical Sciences, and Pharmaceutical Society of Great Britain., eds. Handbook of pharmaceutical excipients. 2nd ed. American Pharmaceutical Association, 1994.

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Michael, Ash, and Ash Irene, eds. Handbook of pharmaceutical additives. 2nd ed. Synapse Information Resources, 2002.

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Formulate '94 Symposium (1994 Manchester, England). Excipients and delivery systems for pharmaceutical formulations. The Royal Society of Chemistry, 1995.

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Bugay, David E. Pharmaceutical excipients: Characterization by IR, Raman, and NMR spectroscopy. M. Dekker, 1999.

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Survey of active pharmaceutical ingredients-excipient incompatibility. LAP LAMBERT Academic Publishing AG & Co. KG, Dudweiler Landstr. 99, 66123 Saarbrücken, Germany, 2010.

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Survey of active pharmaceutical ingredients-excipient incompatibility. LAP LAMBERT Academic Publishing AG & Co. KG, Dudweiler Landstr. 99, 66123 Saarbrücken, Germany, 2010.

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Weiner/KotKosKi. Excipient Toxicity and Safety (Drugs and the Pharmaceutical Sciences). Informa Healthcare, 1999.

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Book chapters on the topic "Pharmaceutical excipient"

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Good, David, and Yongmei Wu. "Excipient Characterization." In Pharmaceutical Excipients. John Wiley & Sons, Inc., 2016. http://dx.doi.org/10.1002/9781118992432.ch1.

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Nahler, Gerhard. "excipient." In Dictionary of Pharmaceutical Medicine. Springer Vienna, 2009. http://dx.doi.org/10.1007/978-3-211-89836-9_522.

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Moreton, R. C. "Excipient Standards and Harmonization." In Pharmaceutical Excipients. John Wiley & Sons, Inc., 2016. http://dx.doi.org/10.1002/9781118992432.ch5.

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Mittal, Vishnu, Anjali Sharma, and Devkant Sharma. "Inulin as a Pharmaceutical Excipient." In Inulin for Pharmaceutical Applications. Springer Nature Singapore, 2025. https://doi.org/10.1007/978-981-97-9056-2_8.

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Vashisth, Priya, Harmeet Singh, Parul A. Pruthi, and Vikas Pruthi. "Gellan as Novel Pharmaceutical Excipient." In Handbook of Polymers for Pharmaceutical Technologies. John Wiley & Sons, Inc., 2015. http://dx.doi.org/10.1002/9781119041375.ch1.

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Silverstein, Irwin. "Pharmaceutical Excipient Good Manufacturing Practices." In Good Manufacturing Practices for Pharmaceuticals. CRC Press, 2019. http://dx.doi.org/10.1201/9781315120669-16.

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Lee, Carlos. "Addressing Drug–Excipient Interactions." In Sample Preparation of Pharmaceutical Dosage Forms. Springer US, 2011. http://dx.doi.org/10.1007/978-1-4419-9631-2_6.

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Desai, Parind M., Lai Wah Chan, and Paul Wan Sia Heng. "Drug Substance and Excipient Characterization." In Handbook of Pharmaceutical Granulation Technology, 4th ed. CRC Press, 2021. http://dx.doi.org/10.1201/9780429320057-3-4.

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Schalau, Gerald K., and Hyder A. Aliyar. "Silicone Excipients in Pharmaceutical Drug Delivery Applications." In Excipient Applications in Formulation Design and Drug Delivery. Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-20206-8_14.

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Gogos, Costas G. "Excipient or API Melt Processing via Injection Molding." In AAPS Advances in the Pharmaceutical Sciences Series. Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-8432-5_11.

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Conference papers on the topic "Pharmaceutical excipient"

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Korde, Shrivatsa, Aishwarya Menon, Gintaras V. Reklaitis, and Zoltan K. Nagy. "Active Pharmaceutical Ingredients from Unused Solid Drugs." In The 35th European Symposium on Computer Aided Process Engineering. PSE Press, 2025. https://doi.org/10.69997/sct.174860.

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The increased use of pharmaceuticals globally over the past two decades has contributed to an increase in unused pharmaceuticals and a corresponding surge in pharmaceutical waste. Thus, there is an impetus for the development of processes for the recovery of the active pharmaceutical ingredients (APIs) from these unused drugs. This study introduces a decision framework for solvent selection to enable the recovery of APIs using a general separation train where cooling crystallization is the final step. The framework is designed to base solvent selection not just on the solubilities of the formu
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Brands, Ren�, Vikas Kumar Mishra, Jens Bartsch, Mohammad Al Khatib, Markus Thommes, and Naim Bajcinca. "From Experiment Design to Data-Driven Modeling of Powder Compaction Process." In The 35th European Symposium on Computer Aided Process Engineering. PSE Press, 2025. https://doi.org/10.69997/sct.101076.

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Tableting is a dry granulation process for compacting powder blends into tablets. In this process, a blend of active pharmaceutical ingredients (APIs) and excipients are fed into the hopper of a rotary tablet press via feeders. Inside the tablet press, rotating feed frame paddle wheels fill powder into dies, with tablet mass adjusted by the lower punch position during the die filling process. Pre-compression rolls press air out of the die, while main compression rolls apply the force necessary for compacting the powder into tablets. In this paper, process variables such as feeder screw speeds,
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Wei, Yuxiao, Isaac J. Pence, and Conor L. Evans. "Quantitative analysis of drug tablet aging by fast hyperspectral stimulated Raman scattering microscopy." In Novel Techniques in Microscopy. Optica Publishing Group, 2023. http://dx.doi.org/10.1364/ntm.2023.ntu2c.5.

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Pharmaceutical development of solid-state formulations requires testing for uniformity and active pharmaceutical ingredient stability. We demonstrate fast chemical imaging by epi-detected sparse spectral sampling stimulated Raman scattering to quantify API and excipient degradation and distribution.
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Jesus, Kathleen Cristine Andrade de, Ziane Maria Ferreira Menezes, and Luciana Macedo Brito. "Analysis of excipients used in capsules prepared in magistral pharmacies of the Baixada Fluminense-RJ." In III SEVEN INTERNATIONAL MULTIDISCIPLINARY CONGRESS. Seven Congress, 2023. http://dx.doi.org/10.56238/seveniiimulti2023-244.

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Magistral pharmacies currently represent an important segment in the Brazilian drug market. It is known that in magistral preparations, drugs are associated with excipients, which are substances that have different characteristics and functions, helping in pharmaceutical formulations. The inappropriate use of these adjuvants can cause interactions with the drug and thus compromise its bioavailability and therapeutic efficacy. Based on this fact, the objective of this work was to evaluate the excipients used in magistral preparations, in the pharmaceutical form of capsules, in magistral pharmac
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Benkő, Ernő Máté, Tamás Sovány, and Ildikó Csóka. "API – excipient interactions in non-biodegradable solid matrix systems." In I. Symposium of Young Researchers on Pharmaceutical Technology,Biotechnology and Regulatory Science. Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Faculty of Pharmacy, 2019. http://dx.doi.org/10.14232/syrptbrs.2019.op9.

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Benkő, Ernő Máté, Tamás Sovány, and Ildikó Csóka. "API – excipient interactions in non-biodegradable solid matrix systems." In II. Symposium of Young Researchers on Pharmaceutical Technology,Biotechnology and Regulatory Science. Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Faculty of Pharmacy, 2020. http://dx.doi.org/10.14232/syrptbrs.2020.op28.

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Markopoulos, Evangelos, and Chrystalla Protopapa. "Machine Reading Comprehension and Expert System technologies for social innovation in the drug excipient selection process." In 14th International Conference on Applied Human Factors and Ergonomics (AHFE 2023). AHFE International, 2023. http://dx.doi.org/10.54941/ahfe1003273.

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The growth of the global population together with several unpredicted crises such as political, health, and financial, create an environment of uncertainty in which social innovations can be developed to offer stability in people’s lives and create new business development opportunities for the benefit of the economy and the society. One of the undoubted rights of every human being is access to affordable medical treatment. However, the costs and time needed for research and development on new or specialized drugs are not often covered by governmental budgets and initiatives that could make su
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Bruguera Teixidor, M., R. Aguilar Salmerón, E. Martínez Díaz, et al. "5PSQ-124 Exceeding safe excipient limits in neonatology unit medications: a call for safer pharmaceutical alternatives." In 29th EAHP Congress, Copenhagen, Denmark, 12-13-14 March 2025, Person centred pharmacy — Navigating digital health. British Medical Journal Publishing Group, 2025. https://doi.org/10.1136/ejhpharm-2025-eahp.419.

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Baumgartner, Ana, and Odon Planinšek. "Development and optimisation of a novel free-flowing and compressible co-processed excipient containing mesoporous silica and isomalt for the production of solid dispersions." In IV. Symposium of Young Researchers on Pharmaceutical Technology,Biotechnology and Regulatory Science. Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Faculty of Pharmacy, 2022. http://dx.doi.org/10.14232/syrptbrs.2022.15.

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Löbmann, Korbinian. "Amorphous stabilisation using proteins as excipients." In The 1st International Electronic Conference on Pharmaceutics. MDPI, 2020. http://dx.doi.org/10.3390/iecp2020-08783.

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