Relevant bibliographies by topics / Pharmaceutical excipient / Dissertations / Theses
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Dissertations / Theses on the topic 'Pharmaceutical excipient'

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Published: 14 July 2021
Last updated: 25 July 2025

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1

Nep, E. I. "Grewia polysaccharide gum as a pharmaceutical excipient." Thesis, Aston University, 2010. http://publications.aston.ac.uk/10310/.

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Grewia gum is obtained from the inner stem bark of the edible plant Grewia mollis Juss (Fam. Tiliaceae) which grows widely in the middle belt region of Nigeria, and is also cultivated. The dried and pulverised inner stem bark is used as a thickening agent in some food delicacies in that region of the country. This ability of the material to increase solution viscosity has generated a lot of interest and is the catalysing momentum for this research. Such materials have been used as stabilizers or suspending agents in cosmetics, foods and liquid medications, and as mucoadhesives and controlled r
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2

Mackin, L. A. "The effects of moisture on triboelectrification of selected pharmaceutical excipient powders." Thesis, University of Sunderland, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.245985.

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The literature contains conflicting reports on the effect of moisture on triboelectrification, indeed experiments have shown moisture to increase, decrease or have no effect at all on the charging of solids. The research programme investigated the role of moisture in the triboelectrification of a range of pharmaceutical excipients. Selection of excipients was made on the basis of a) moisture sorption capacity (the starch group) and b) potential use in dry powder inhaler formulations (the sugar and sorbitol group). The following excipients were selected for preliminary investigations:- a-lactos
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3

Camargo, Jhon Jairo Rojas. "Assessment of co-processing of cellulose II and silicon dioxide as a platform to enhance excipient functionality." Diss., University of Iowa, 2011. https://ir.uiowa.edu/etd/2763.

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This thesis project studied microcrystalline cellulose II (CII), a polymorphic form of cellulose, which has lower mechanical properties, less plastic deformation, higher elastic recovery and faster disintegration properties than microcrystalline cellulose I (CI). Also, the effects of processing and silicification on CII materials were investigated. Particle modification through spray drying, wet granulation and spheronization was employed to improve CII performance. Spray-drying (SDCII) and wet granulation (WGCII) produced materials with no difference in mechanical or disintegration properties
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4

Tant, Martin Ray. "Biopharmaceutic and Pharmacokinetic Studies of Sucrose Acetate Isobutyrate as an Excipient for Oral Drug Delivery." Digital Commons @ East Tennessee State University, 2011. https://dc.etsu.edu/etd/1345.

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Sucrose acetate isobutyrate (SAIB), a randomly substituted sucrose approximating sucrose diacetate hexaisobutyrate, is produced by Eastman Chemical Company for a variety of applications. SAIB is widely used in the food industry as a weighting agent to disperse flavoring oils in primarily citrus-based soft drink beverages. Additionally, SAIB is currently being marketed by another company as a parenteral drug delivery system. The studies reported here focused on investigating SAIB as an excipient, or delivery vehicle, for use in oral delivery of several drugs, including ibuprofen, saquinavir, an
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5

Tinmanee, Radaduen. "The role of pharmaceutical excipients in the solid-state degradation of Gabapentin." Diss., University of Iowa, 2015. https://ir.uiowa.edu/etd/1919.

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Drug instability in solid dosage forms includes chemical or physical processes involving covalent or polymorphic transformations wherein different polymorphs possess crystal structure differences. Gabapentin chemically degrades by intramolecular cyclization to gabapentin-lactam (lactam) in the solid-state. Additionally, gabapentin undergoes polymorphic solid-state transformations. A kinetic model was developed to describe the environmental and excipient effects on chemical and physical instability associated with milling induced stress and subsequent storage under controlled temperature and hu
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6

Gupta, Patel Salin. "MECHANISMS AND THERMODYNAMICS OF THE INFLUENCE OF SOLUTION-STATE INTERACTIONS BETWEEN HPMC AND SURFACTANTS ON MIXED ADSORPTION ONTO MODEL NANOPARTICLES." UKnowledge, 2019. https://uknowledge.uky.edu/pharmacy_etds/103.

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Nanoparticulate drug delivery systems (NDDS) such as nanocrystals, nanosuspensions, solid-lipid nanoparticles often formulated for the bioavailability enhancement of poorly soluble drug candidates are stabilized by a mixture of excipients including surfactants and polymers. Most literature studies have focused on the interaction of excipients with the NDDS surfaces while ignoring the interaction of excipients in solution and the extent to which the solution-state interactions influence the affinity and capacity of adsorption. Mechanisms by which excipients stabilize NDDS and how this informati
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7

El, Sanadi Caroline Elizabeth. "THE VALUE OF A FUNCTIONAL EXCIPIENT ADDITIVE TO HUMAN INSULIN THERAPIES: FROM MANUFACTURE TO HUMAN CLINICAL TRIAL." Case Western Reserve University School of Graduate Studies / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=case1450286879.

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8

Elgaied-Lamouchi, Dhouha. "Découverte de nouveaux excipients pharmaceutiques à base d'amidons modifiés pour une libération prolongée d'une substance active." Thesis, Lille, 2020. https://pepite-depot.univ-lille.fr/.

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Les comprimés matriciels hydrophiles sont fréquemment utilisés pour contrôler la libération d’actif dans les formes galéniques à usage oral. Les amidons représentent un choix intéressant pour cette application. En effet, ce sont des matériaux biocompatibles, biodégradables et disponibles à partir de différentes sources végétales. En plus des amidons natifs, les amidons modifiés (AM) ont été beaucoup étudiés pour la formulation des comprimés matriciels à libération prolongée. Les modifications physico-chimiques peuvent être ajustées de manière à correspondre aux propriétés souhaitées pour une a
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9

Velásquez, Armijo Cristián Jesús. "Aplicação de métodos termo-analíticos e espectroscóspicos na avaliação do comportamento do fármaco isoniazida frente a adjuvantes tecnológicos." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2003. http://hdl.handle.net/10183/144233.

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Os métodos termo-analíticos são ferramentas úteis na avaliação da compatibilidade entre fármacos e adjuvantes, com destaque à calorimetria exploratória diferencial. Neste trabalho foram avaliados a compatibilidade e o comportamento térmico entre a isoniazida e adjuvantes tecnológicos primários usualmente empregados em formas farmacêuticas sólidas. A compatibilidade foi examinada por meio da preparação de misturas físicas binárias do tipo fármaco/adjuvante. Foi investigada também a influência da granulação por via úmida e do processo de compactação para as misturas de isoniazida e adjuvantes co
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10

Mansa, Rola. "Preparation and Characterization of Novel Montmorillonite Nanocomposites." Thèse, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/20207.

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Clay minerals have historically played a consequential role in human health. While the beginnings were rooted in geophagy, a primitive act of consuming earth, the health-related uses of clay minerals have evolved and diversified over time. As excipients in pharmaceutical formulations, clay minerals can attribute novel properties onto intercalated compounds. Intercalating oxybenzone, a UV filter, within the interlamellar space of montmorillonite is desirable in order to minimize direct contact with skin. Intercalating resveratrol, a compound known for attributing beneficial effects onto hum
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11

Yu, Shen. "Roll compaction of pharmaceutical excipients." Thesis, University of Birmingham, 2013. http://etheses.bham.ac.uk//id/eprint/4137/.

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Roll compaction is commonly used as a dry granulation technique in the pharmaceutical industry to produce tablets for formulations sensitive to heat and moisture. This thesis reports systematic studies on the behavior of pharmaceutical excipients in associated unit operations (i.e. roll compaction, milling, tabletting), as well as their correlations. Roll compaction experiments were carried out using an instrumented roll compactor with a gravity feeding system. The influence of the process parameters, material properties and powder conditioning were investigated Ribbons produced in roll compac
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12

Ashiru, Diane A. I. "Modulating Intestinal Absorption Using Pharmaceutical Excipients." Thesis, University College London (University of London), 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.509950.

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13

Buggins, Talia Rae. "Effects of pharmaceutical excipients on drug disposition." Thesis, Cardiff University, 2007. http://orca.cf.ac.uk/55658/.

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This thesis investigates the potential of some commonly used pharmaceutical excipients to alter drug pharmacokinetics. In breath test studies, 3.2ml/kg DMSO prolonged the half-life of 14C-aminopyrine, -erythromycin and -NDMA, indicating in vivo inhibition of metabolism by CYP3A (erythromycin), CYP2E1 (NDMA) and the variety of enzymes that metabolise aminopyrine (CYP 2C11, 2C12, 2B1 and 2B2). However, no effects were apparent at doses typically used in pre-clinical formulations. Aminopyrine and erythromycin breath tests were not affected by propylene glycol (PG) or Solutol HS15, however PG did
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14

Dogbe, Selasi Cudjoe. "Predictive milling of active pharmaceutical ingredients and excipients." Thesis, University of Leeds, 2016. http://etheses.whiterose.ac.uk/17937/.

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Spiral jet milling is a size reduction process used in various industries, ranging from paints to food and pharmaceuticals. It has great benefit in the pharmaceutical industry due to its ability to reduce particulate solids to micron sizes and narrow size distributions. Despite its heavy usage, the underlying size reduction mechanism of the mill is not well understood. However it is generally known that the milling behaviour is dependent on the grinding conditions of the mill, as well as the materials physical and mechanical properties. The system is also very energy inefficient. In this work
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15

Doherty, C. "Microenvironmental role of pharmaceutical excipients in drug dissolution control." Thesis, University of Bradford, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.374915.

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16

Mai, Yang. "Sex-specific modulation of drug bioavailability with pharmaceutical excipients." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10044027/.

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The biopharmaceutics classification system (BCS) is a framework for classifying drug substances based on their aqueous solubility and permeability across a biological membrane. It is possible for individuals to request a waiver of in vivo bioequivalence (BE) studies for immediate-release solid oral dosage forms. Nowadays, the Food and Drug Administration allows the biowaiver for BCS Class I and Class III drugs. However, the findings in this thesis call attention to the unearthed loopholes in this regulation, given that formerly considered “inert” pharmaceutical excipients have shown unexpected
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17

Gaisford, Simon. "Kinetic and thermodynamic investigation of a series of pharmaceutical excipients." Thesis, University of Kent, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.242881.

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18

Mansa, Rachel Fran. "Roll compaction of pharmaceutical excipients and prediction using intelligent software." Thesis, University of Birmingham, 2007. http://etheses.bham.ac.uk//id/eprint/5406/.

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Roll compaction is a dry granulation method. In the pharmaceutical industry it assists in binding tablet ingredients together to form a larger mass. This is conducted to ease subsequent processing, decrease dust, improve flowability, improve material distribution, more suitable for moisture and heat sensitive materials than wet granulation methods, minimises operating space and suited for a continuous manufacturing set-up. In pharmaceutical roll compaction various types of powder material mixtures are compacted into ribbon that are subsequently milled and tableted. The aim of this research is
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19

Garr, Joseph Sunday Mola. "Compaction characteristics of direct compression tableting excipients." Thesis, Liverpool John Moores University, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.261399.

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20

Lucero, Borja Diego Sebastián. "Solubility and Dissolution Rate of Active Pharmaceutical Ingredients: Dissolution Media and Effect of Enhancers." Doctoral thesis, Universitat de Barcelona, 2021. http://hdl.handle.net/10803/671762.

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The present doctoral thesis is focused on the effect of pH, enhancers and biorelevant media in the Solubility and the Dissolution Rates of some selected acidic active pharmaceutical ingredients (API). Because of the effect of these physicochemical parameters in the bioavailability of drugs and their pharmacological action, deepen the knowledge on the factors affecting the dissolution properties is of paramount importance in the drug development process. Solubility and dissolution rates are examined in different aqueous solutions and buffering systems, accounting for the pH values of main inte
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21

Cote, Marie. "Solubility and phase behaviour of selected pharmaceutical excipients in 2h, 3h-perfluoropentane." Thesis, Cardiff University, 2008. http://orca.cf.ac.uk/54770/.

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The behaviour of pharmaceutical excipients was studied in 2H, 3H-perfluoropentane (HPFP), a partially fluorinated liquid considered as a highly suitable model propellant for medicinal pressurized metered-dose inhalers (pMDIs) used in drug delivery to the lungs. The additives chosen belonged to three main categories: ethylene oxide oligomers and derivatives, chosen for their wide range of applications in pharmaceutical formulations, their harmlessness and low cost a hydrophobically modified cyclodextrin that shows potential for controlled release via host-guest interactions and some interesting
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22

Schulze, Julia. "The in vivo effects of pharmaceutical excipients on gastrointestinal transit and drug absorption." Thesis, University College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406724.

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23

Donnelly, Conor Michael. "Rationalising the selection of pharmaceutical excipients for the formulation of amorphous solid dispersions." Thesis, Queen's University Belfast, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.680168.

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24

Lerdkanchanaporn, Supaporn. "Application of thermal analysis to ibuprofen and associated formulation excipients." Thesis, University of Hertfordshire, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.302281.

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25

Ananieva, V. V., S. О. Petrov, and D. S. Goloborodko. "Search of new excipients in technology of farmaceutical drugs." Thesis, Національний технічний університет "Харківський політехнічний інститут", 2018. http://repository.kpi.kharkov.ua/handle/KhPI-Press/45931.

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26

Yang, Xue. "Evaluation of Cucurbit[7]uril and its derivative for their use as pharmaceutical excipients." Thesis, University of Macau, 2017. http://umaclib3.umac.mo/record=b3690845.

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27

Mohlala, Mangaabane Gorden. "The effect of pharmaceutical excipients on rifampicin release from chitosan beads / Mangaabane Gorden Mohlala." Thesis, North-West University, 2004. http://hdl.handle.net/10394/484.

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Controlled release systems aim at achieving a predictable and reproducible drug release over a desired time period. These systems allow reduced dosing frequency, constant drug levels in the blood, increased patient compliance and decreased adverse effects. In a recent study, Chitosan beads, containing N-trimethyl Chitosan chloride, have shown a potential in the delivery of rifampicin. However, because of inadequate amounts of rifampicin released over 24 hours, incorporation of other pharmaceutical excipients to increase the swelling behaviour of the beads to improve drug release, was considere
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28

Van, Rensburg Andries Gideon. "The effect of pharmaceutical excipients on isoniazid release from chitosan beads / Deon van Rensburg." Thesis, North-West University, 2007. http://hdl.handle.net/10394/1248.

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In controlled release applications a drug is molecularly dispersed in a polymer phase. In the presence of a thermodynamically compatible solvent, swelling occurs and the polymer releases its content to the surrounding medium. The rate of the drug release can be controlled by interfering with the swelling rate of the beads or by influencing diffusion through the viscosity of the polymer. Beads that contain chitosan were prepared through the ionotropic gelation method where tripolyphosphate (TPP) was used as the crosslinking agent. Beads that consisted of 3% w/v isoniazid (lNH) and 5% w/v chitos
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29

Darkwah, Joseph. "Protein stability : impact of formulation excipients and manufacturing processes in protein-based pharmaceuticals." Thesis, De Montfort University, 2017. http://hdl.handle.net/2086/16284.

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Presently, over 300 proteins or peptide based therapeutic medicines have been approved by the FDA owing to advances in protein engineering and technology. However, majority of these protein-based medications are unstable or have limited shelf life when in aqueous form. During pre-formulation and manufacturing, various technological processes including mixing, dissolving, filling (through pipes) can produce strong mechanical stresses on proteins. These stresses may cause the protein molecule to unfold, denature or aggregate. To improve stability upon formulation, they may be manufactured as fre
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30

Havinga, Riana. "The effect of pharmaceutical excipients on the release of indomethacin from chitosan beads / Riana Havinga." Thesis, North-West University, 2006. http://hdl.handle.net/10394/4.

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Contents: Chitosan -- Controlled drug delivery -- Indomethacin -- Inotropic gelation -- Tripolyphosphate (TPP) -- Explotab® -- Ac-Di-Sol® -- Vitamin C<br>Thesis (M.Sc. (Pharmaceutics))--North-West University, Potchefstroom Campus, 2007.
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31

Bisharat, Lorina Milad Nae’m. "An investigation into the use of zein proteins as pharmaceutical excipients for modified drug release applications." Thesis, University of East Anglia, 2012. https://ueaeprints.uea.ac.uk/39448/.

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32

Mi, Yanli. "Protection Mechanisms of Excipients on Lactate Dehydrogenase during Freeze-Thawing and Lyophilization." View the abstract Download the full-text PDF version, 2002. http://etd.utmem.edu/WORLDACCESS/ymi/default.htm.

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33

Ali, H. R. H. "Vibrational spectroscopic techniques (Raman, FT-IR and FT-NIR spectroscopy) as a means for the solid-state structural analysis of pharmaceuticals." Thesis, University of Bradford, 2009. http://hdl.handle.net/10454/3343.

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The aim of this work was to assess the suitability of vibrational spectroscopic techniques (Raman, FT-IR and FT-NIR spectroscopy) as a means for the solid-state structural analysis of pharmaceuticals. Budesonide, fluticasone propionate, salbutamol hemisulfate, terbutaline hemisulfate, ipratropium bromide, polymorphic forms of salmeterol xinafoate and two polymorphic forms of sulfathiazole were selected since they are used in the management of certain respiratory disorders and from different chemical and pharmacological entities along with some pharmaceutical excipients. Conventional visual exa
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34

Setiawan, Nico. "UNDERSTANDING THE THERMODYNAMICS AND ORAL ABSORPTION POTENTIAL OF PHARMACEUTICAL AMORPHOUS SOLID DISPERSIONS." UKnowledge, 2018. https://uknowledge.uky.edu/pharmacy_etds/85.

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Supersaturating drug delivery systems, such as amorphous solid dispersions (ASDs), have been used extensively to elevate the apparent solubility and oral bioavailability of poorly water-soluble drugs. However, despite the numerous examples of success in increasing solubility and oral bioavailability using ASDs, physical stability challenges remain as formulators seek to employ high drug loading for cost reduction and improved patient compliance. Therefore, stability in both the solid and solution state must be considered for ASDs to be successful. In the solid state, the drug must remain amorp
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35

Hillgren, Anna. "Investigation of the Freeze-Thawing Process for Pharmaceutical Formulations of a Model Protein." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2002. http://publications.uu.se/theses/91-554-5304-X/.

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36

Xia, Xin. "Dissolving the Rocks : Solubility Enhancement of Active Pharmaceutical Ingredients using Mesoporous Silica." Doctoral thesis, Stockholms universitet, Institutionen för material- och miljökemi (MMK), 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-103190.

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Poor aqueous solubility is one of the greatest barriers for new drug candidates to enter toxicology studies, let alone clinical trials. This thesis focuses on contributing to solving this problem, evaluating the oral toxicity of mesoporous silica particles, and enhancing the apparent solubility and bioavailability of active pharmaceutical ingredients in vitro and in vivo using mesoporous silica particles. Toxicological studies in rats showed that two types of mesoporous silica particles given by oral administration were well tolerated without showing clinical signs of toxicity. Solubility enha
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37

Ilko, David [Verfasser], Ulrike [Gutachter] Holzgrabe, and Petra [Gutachter] Högger. "The use of charged aerosol detection for the analysis of excipients and active pharmaceutical ingredients / David Ilko. Gutachter: Ulrike Holzgrabe ; Petra Högger." Würzburg : Universität Würzburg, 2015. http://d-nb.info/1112943218/34.

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38

Nyman, Olof. "Är generiska bröstcancerläkemedel likvärdiga ur alla kliniskt betydelsefulla aspekter?" Thesis, Linnéuniversitetet, Institutionen för kemi och biomedicin (KOB), 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-34144.

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Bröstcancer är den vanligaste cancerformen hos kvinnor. I ca 80 % av fallen är cancern hormonpositiv. Förutom operation och cytostatika används läkemedel som antingen förhindrar att östrogen kan binda till sina receptorer eller minskar bildningen av östrogen. Denna typ av behandling är förknippad med en rad biverkningar. Vissa biverkningar kan kopplas till östrogenets minskade effekter i kroppen. Andra biverkningar är mer svårförklarliga. Det är dessutom inte helt ovanligt att patienter upplever starkare biverkningar av vissa generiska preparat, trots att de anses likvärdiga. För att läkemedel
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39

Lagercrantz, Forss Louise. "Adhesive mixtures for dry powder inhalation." Thesis, Uppsala universitet, Institutionen för farmaceutisk biovetenskap, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-447786.

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When it comes to dry powder inhalation (DPI), adhesive mixtures are the most widely used formulation type. Various techniques have been developed to generate inhaled drug particles and improve the delivery efficiency of DPI formulations. For dry powder inhaler formulations (DPIs), micronized drug powders are usually mixed with lactose carriers to improve powder handling during manufacturing and powder aerosol delivery during patient use. The performance of DPI systems is strongly dependent on several formulation factors, the construction of the delivery device and the inhalation technique. The
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40

Urlaub, Jonas [Verfasser], Ulrike [Gutachter] Holzgrabe, and Ann-Christin [Gutachter] Pöppler. "Development of analytical methods for the quality assessment of mineral oil based excipients and mechanochemically stressed active pharmaceutical ingredients / Jonas Urlaub ; Gutachter: Ulrike Holzgrabe, Ann-Christin Pöppler." Würzburg : Universität Würzburg, 2021. http://d-nb.info/1240148011/34.

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41

Junior, Alcidesio Sales de Souza. "Estudo retrospectivo sobre o uso de medicamentos em neonatos internados em uma Unidade de Terapia Intensiva Neonatal em BrasÃlia-DF." Universidade Federal do CearÃ, 2014. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=13058.

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nÃo hÃ<br>Neonatos internados em unidade de terapia intensiva neonatal (UTIN) sÃo expostos a uma grande variedade de medicamentos, a maioria sem dados de seguranÃa e eficÃcia. Descrever o perfil de uso de medicamentos em neonatos em UTIN de um hospital pÃblico no Brasil de acordo com dados de registro do medicamento e potencial nocivo destes, foi o objetivo do trabalho. Trata-se de um estudo descritivo retrospectivo sobre uso de medicamentos em UTIN, envolvendo neonatos internados por mais de 24 horas e dados de prescriÃÃo coletados em prontuÃrio eletrÃnico durante o perÃodo de janeiro a junho
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42

Boc, Susan. "Aerosolized Surfactants: Formulation Development and Evaluation of Aerosol Drug Delivery to the Lungs of Infants." VCU Scholars Compass, 2018. https://scholarscompass.vcu.edu/etd/5577.

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The overall aim of this research project was to develop surfactant dry powder formulations and devices for efficient delivery of aerosol formulations to infants using the excipient enhanced growth (EEG) approach. Use of novel formulations and inline delivery devices would allow for more efficient treatment of infants suffering from neonatal respiratory distress syndrome and bronchiolitis. A dry powder aerosol formulation has been developed using the commercial product, Survanta ® (beractant) and EEG technology to produce micrometer-sized hygroscopic particles. Spray drying and formulation para
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43

Busignies, Virginie. "Recherche de lois de mélange sur des propriétés mécaniques de systèmes granulaires compactés." Phd thesis, Université Paris Sud - Paris XI, 2005. http://tel.archives-ouvertes.fr/tel-00012167.

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Les matériaux granulaires sont utilisés dans de nombreux domaines tels que la pharmacie, la chimie, la métallurgie, l'agroalimentaire. Ils font l'objet de nombreuses recherches théoriques et expérimentales. La compression en matrice fermée est un procédé économique et facile à automatiser, ce qui explique qu'elle soit très répandue dans les industries qui utilisent des milieux granulaires. Dans le domaine pharmaceutique, le comprimé reste la forme la plus présente sur le marché. Bien que simple en apparence, la compression est un processus dynamique irréversible d'une grande complexité. Dans l
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44

Navarro, Marco Vin?cius Monteiro. "Emprego de redes neurais artificiais supervisionadas e n?o supervisionadas no estudo de par?metros reol?gicos de excipientes farmac?uticos s?lidos." Universidade Federal do Rio Grande do Norte, 2014. http://repositorio.ufrn.br:8080/jspui/handle/123456789/13866.

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Made available in DSpace on 2014-12-17T14:25:22Z (GMT). No. of bitstreams: 1 MarcoVMN_TESE.pdf: 3982733 bytes, checksum: 381ae79721c75a30e3373fe4487512c7 (MD5) Previous issue date: 2014-02-05<br>In this paper artificial neural network (ANN) based on supervised and unsupervised algorithms were investigated for use in the study of rheological parameters of solid pharmaceutical excipients, in order to develop computational tools for manufacturing solid dosage forms. Among four supervised neural networks investigated, the best learning performance was achieved by a feedfoward multilayer perceptr
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45

Chitu, Toma-Mihai. "Granulation humide des poudres cohésives : rhéologie, mécanismes de croissance et tenue mécanique des granules." Thesis, Toulouse, INPT, 2009. http://www.theses.fr/2009INPT040G/document.

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Cette étude est dédiée à la compréhension du processus de granulation humide en mélangeurs à haut taux de cisaillement. Une étude systémique et méthodologique a été menée permettant l'investigation de l'influence des paramètres opératoires, de la technologie employée et des propriétés physico-chimiques des matières premières. Cette investigation est réalisé a travers des techniques de caractérisation morphologiques, rhéologiques et mécaniques. En reliant les courbes de couple enregistrés lors de la granulation humide à la cinétique de croissance des granules, aux caractérisations microscopique
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46

Bai, Shujun. "Understanding physicochemical stability of proteins in solution and development of new analytical methods for freeze-dried protein formulations /." Connect to full text via ProQuest. Limited to UCD Anschutz Medical Campus, 2008.

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Thesis (Ph.D. in Pharmaceutical Sciences) -- University of Colorado Denver, 2008.<br>Typescript. Includes bibliographical references (leaves 134-146). Free to UCD Anschutz Medical Campus. Online version available via ProQuest Digital Dissertations;
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47

Danielsson, Linnea. "XRF för kvalitetskontroll av farmaceutiska råvaror : - metodutveckling och utbildning av användare." Thesis, KTH, Skolan för teknikvetenskap (SCI), 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-93444.

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Detta examensarbete dokumenterar arbetet med utveckling, införande och dokumentation av en nymetod för identitetsbestämning av farmaceutiska råvaror med röntgenfluorescens. Metoden ärutvecklad för att användas på laboratorier för kvalitetskontroll på AstraZeneca i Södertälje. Syftetmed arbetet var att utveckla en robust och effektiv metod samt att utbilda användarna i dethanteringssätt som krävs för att utföra snabba och korrekta analyser. Rapporten presenterarteknologin bakom röntgenfluorescensinstrument och vilka felkällor som kan påverka resultaten samtde pedagogiska teorier som använts för
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48

Santos, Ana Isabel Caldeira Freitas dos. ""Dendrimers as Pharmaceutical Excipients"." Master's thesis, 2019. http://hdl.handle.net/10316/88283.

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Relatório de Estágio do Mestrado Integrado em Ciências Farmacêuticas apresentado à Faculdade de Farmácia<br>O estágio curricular é um momento crucial de aplicação de todos os conhecimentos adquiridos, sendo também um período de grande aprendizagem. Com base nesta evidência,decidi repartir o meu estágio curricular por duas áreas diferentes (Indústria Farmacêutica e Farmácia Comunitária), de modo a contactar com várias realidades e ganhar uma nova visão sobre o mercado farmacêutico.O estágio nos Laboratórios Basi possibilitou a perceção do papel do farmacêutico no funcionamento de uma indústria
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49

Cardoso, Sara Sofia Dias. "Generic drug product development of a modified-release oral dosage form." Master's thesis, 2018. http://hdl.handle.net/10316/84678.

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Dissertação de Mestrado em Tecnologias do Medicamento apresentada à Faculdade de Farmácia<br>O presente projeto visa o desenvolvimento de um medicamento genérico de libertação prolongada para administração oral, sob a forma farmacêutica de comprimidos não revestidos. O projeto foi desenvolvido na Bluepharma Indústria Farmacêutica, S.A. e foi referido como Blue055, de acordo com a política de confidencialidade da empresa.Os principais objetivos do projeto foram desenvolver uma formulação, um processo de fabrico e produzir protótipos capazes de mimetizar o comportamento in vitro do produto de re
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50

Marques, Ana Margarida Almeida. "Investigação de Cocristais Farmacêuticos e Estudos de Compatibilidade cocristal-excipiente. Dois Casos de Estudo: diflunisal-isoniazida e lamotrigina-etossuximida." Master's thesis, 2021. http://hdl.handle.net/10316/97965.

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Dissertação de Mestrado em Química apresentada à Faculdade de Ciências e Tecnologia<br>Esta dissertação teve como objetivo o estudo de cocristais com potencial para utilização em terapia dual, tendo-se, para isso, investigado os sistemas binários constituídos por diflunisal, um anti-inflamatório não esteróide, e isoniazida, um tuberculostático; diflunisal e etossuximida, um anticonculsivante; assim como o sistema que junta dois anticonvulsivantes com mecanismos de ação distintos, a lamotrigina e a etossuximida. O trabalho teve, ainda, como objetivo contribuir para o conhecimento da estabilidad
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