Log in

Relevant bibliographies by topics / Pharmaceutical ingredients / Journal articles

To see the other types of publications on this topic, follow the link: Pharmaceutical ingredients.

Journal articles on the topic 'Pharmaceutical ingredients'

Author: Grafiati

Published: 4 June 2021

Last updated: 28 January 2023

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Pharmaceutical ingredients.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Eremenko, Z., V. Pashynska, K. Kuznetsova, O. Shubnyi, N. Sklyar, and A. Martynov. "Microwave dielectrometer application to antibiotic concentration control in water solution." RADIOFIZIKA I ELEKTRONIKA 26, no. 3 (2021): 30–37. http://dx.doi.org/10.15407/rej2021.03.030.

Full text

Abstract:

Subject and Purpose. This study focuses on the original waveguide-differential dielectrometer designed for complex permittivity measurements of high-loss liquids in the microwave range towards the determination of pharmaceutical ingredient concentrations in water solutions at room temperature. The suitability of the device and effectiveness of the dielectrometry method are tested on such pharmaceutical ingredients as lincomycin and levofloxacin over a wide range of concentrations. Methods and Methodology. The main idea of the method consists in that the complex propagation coefficients of the HE11 wave are obtained from the amplitude and phase shift differences acquired by the wave after it has passed through the two measuring cells of the waveguide-differential dielectrometer. Results. We have shown that the proposed dielectometry method allows a real-time determination of pharmaceutical ingredient concentrations in water solution by measuring the wave attenuation and phase shift differences. We have found that unless concentrations of pharmaceutical ingredients are low, few free water molecules in water solution are bound to the pharmaceutical ingredients. The number of free water molecules in solution decreases as the concentration of pharmaceutical ingredients rises. Conclusion. The current study confirms that the dielectometry method and the device developed provide effective determination of pharmaceutical ingredient concentrations in water solutions.

APA, Harvard, Vancouver, ISO, and other styles

2

Karpinski, P. H. "Polymorphism of Active Pharmaceutical Ingredients." Chemical Engineering & Technology 29, no. 2 (February 2006): 233–37. http://dx.doi.org/10.1002/ceat.200500397.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Selivanova, I. A. "Fractal Analysis of Lyophilized Active Pharmaceutical Ingredients." Biotekhnologiya 36, no. 5 (2020): 98–103. http://dx.doi.org/10.21519/0234-2758-2020-36-5-98-103.

Full text

Abstract:

The development of effective drug quality control methods based on intelligent technologies is an urgent task for pharmaceutical analysis in the context of production robotization. This is particularly topical for biotechnology-derived pharmaceutical ingredients due to the peculiarities of the analysis of these compounds and limited number of quality control methods for drugs. Fractal geometry can be a mathematical background for the creation of such method. In this work we studied the possibility of fractal geometry using for the development of rapid tests for bifidumbacterin lyophilisates. A correlation was established between the fractal dimension of the structure of the Bifidobacterium bifidum dry mixture solids with sucrose-gelatin-milk medium and the specified pharmaceutical ingredient parameters, such as drug reconstitution time (R2=0,97) and pH (R2=0,95). This work demonstrated that fractal analysis is a promising tool for automated rapid tests of lyophilized biotechnology-derived active pharmaceutical ingredients without losing the analyzed sample. fractal analysis, pharmaceutical analysis, quality control, lyophilisates, bifidumbacterin. This work was supported by the Russian Academic Excellence Project 5-100

APA, Harvard, Vancouver, ISO, and other styles

4

Horáková, Pavlína, and Kamila Kočí. "Continuous-Flow Chemistry and Photochemistry for Manufacturing of Active Pharmaceutical Ingredients." Molecules 27, no. 23 (December 4, 2022): 8536. http://dx.doi.org/10.3390/molecules27238536.

Full text

Abstract:

An active pharmaceutical ingredient (API) is any substance in a pharmaceutical product that is biologically active. That means the specific molecular entity is capable of achieving a defined biological effect on the target. These ingredients need to meet very strict limits; chemical and optical purity are considered to be the most important ones. A continuous-flow synthetic methodology which utilizes a continuously flowing stream of reactive fluids can be easily combined with photochemistry, which works with the chemical effects of light. These methods can be useful tools to meet these strict limits. Both of these methods are unique and powerful tools for the preparation of natural products or active pharmaceutical ingredients and their precursors with high structural complexity under mild conditions. This review shows some main directions in the field of active pharmaceutical ingredients’ preparation using continuous-flow chemistry and photochemistry with numerous examples of industry and laboratory-scale applications.

APA, Harvard, Vancouver, ISO, and other styles

5

Gazi, Ayesha Siddiqua, Amena Begum, and Sumayeh Begum. "AN OVERVIEW ON PHARMACEUTICAL EXCIPIENTS- THEIR ROLES AND APPLICATIONS." International Journal of Pharmaceutical Sciences and Medicine 7, no. 12 (December 30, 2022): 84–96. http://dx.doi.org/10.47760/ijpsm.2022.v07i12.005.

Full text

Abstract:

Excipients play an important role in formulating a dosage form. These are the ingredients which along with Active Pharmaceutical Ingredients make up the dosage forms. Excipients act as protective agents, bulking agents and can also be used to improve bioavailability of drugs in some instances; the following review discusses the various types of excipients along with their uses. The objective of this paper is to indicate the ingredients that possess health effect that can be found in cosmetics and personal care products. The related paper was reviewed in terms of the chemicals that commonly identified in the cosmetic and personal care product. This paper also highlighted the health risk possesses by such ingredients in the products. As we know that dosage form is a combination of active pharmaceutical ingredient (API) and excipients therefore it is clear that any pharmaceutical dosage forms cannot be formulated without the use of excipients. Excipients are the major part of formulation. They do not show any adverse effect but promotes the therapeutic activity of pharmaceutical product. Synthetic excipients have some toxic properties so the uses of natural excipients are coming in the picture. This review shows the uses of natural excipients in modern time and in medicinal sciences.

APA, Harvard, Vancouver, ISO, and other styles

6

Terekhov, Roman Petrovich, Denis Igorevich Pankov, Ekaterina Aleksandrovna Anfinogenova, and Irina Anatolievna Selivanova. "Polymorphism control of active pharmaceutical ingredients." Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology), no. 6 (September 15, 2021): 37–54. http://dx.doi.org/10.33920/med-13-2112-03.

Full text

Abstract:

Рolymorphism is receiving increasing attention due to its influence on the physicochemical and pharmacological properties of the active pharmaceutical ingredients (API) while maintaining the molecular structure. This review is devoted to the problem of APIs phase state control both at the development stage and during the circulation of the drug. The term «polymorphism» has different definitions depending on the branch of science. There is no unambiguous solution to this issue in the regulatory documentation of pharmaceutical industry either. Based on the analysis of literary sources, the article presents a comparison of pharmacopeia methods, recommended in Russian and foreign regulatory documents for the analysis of polymorphism of medicinal substances, including state pharmacopeias of Russia, Belarus, Kazakhstan, the USA, and Japan, as well as international pharmacopeias of the European Economic Union and the Eurasian Economic Union. The trend on using a complex of high-tech equipment is revealed. A systematic approach to analysis based on X-ray diffraction, thermal, spectral, microscopic, biological, and physical methods for determining constants makes it possible not only to identify the polymorphic modification of API, but also to characterize its structure, morphology, physicochemical properties and pharmacological activity. In the Russian Federation, the phenomenon of polymorphism is being studied especially intensively, and some control methods, such as biological methods, are validated only in Russian pharmacopeia. A promising direction for further research is the improvement and harmonization of regulatory documentation within the framework of this chemical and technological field of pharmacy. A global approach will help to reduce not only the probability of poor-quality products entering the market, but also the costs of establishing the authenticity of the active pharmaceutical ingredient produced.

APA, Harvard, Vancouver, ISO, and other styles

7

Zompra, Aikaterini A., Athanassios S. Galanis, Oleg Werbitzky, and Fernando Albericio. "Manufacturing peptides as active pharmaceutical ingredients." Future Medicinal Chemistry 1, no. 2 (May 2009): 361–77. http://dx.doi.org/10.4155/fmc.09.23.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Farina, Vittorio, Jonathan T. Reeves, Chris H. Senanayake, and Jinhua J. Song. "Asymmetric Synthesis of Active Pharmaceutical Ingredients." Chemical Reviews 106, no. 7 (July 2006): 2734–93. http://dx.doi.org/10.1021/cr040700c.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Brinkmann, Joscha, Fabian Huxoll, Christian Luebbert, and Gabriele Sadowski. "Solubility of pharmaceutical ingredients in triglycerides." European Journal of Pharmaceutics and Biopharmaceutics 145 (December 2019): 113–20. http://dx.doi.org/10.1016/j.ejpb.2019.10.012.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Ferraz, Ricardo, Luís C. Branco, Cristina Prudêncio, João Paulo Noronha, and Željko Petrovski. "Ionic Liquids as Active Pharmaceutical Ingredients." ChemMedChem 6, no. 6 (May 9, 2011): 975–85. http://dx.doi.org/10.1002/cmdc.201100082.

Full text

APA, Harvard, Vancouver, ISO, and other styles

11

Singh, Shefali, and Harvinder Popli. "Indian Active Pharmaceutical Ingredient (API) Industry- An overview on Challenges, Opportunities & Regulatory prerequisites." International Journal of Drug Regulatory Affairs 9, no. 2 (June 17, 2021): 66–76. http://dx.doi.org/10.22270/ijdra.v9i2.471.

Full text

Abstract:

Active pharmaceutical ingredient is a chemical compound which is most important raw material to formulate a finished pharmaceutical medicine and has a pharmacological effect. India has a long history of being heavily dependent for these raw materials on China due to one major reason i.e. Low manufacturing cost. But overdependence of APIs imports from China brought various liabilities to India including supply chain disruption and price hikes during pandemic, leading to shortage of various important APIs/KSMs. This COVID 19 widespread has solidly put the center of our country on being “Atma Nirbhar”. And this activity had brought out the strengths, market patterns and opportunities in five divisions counting Healthcare, which are basic from country’s point of view. In view of changing geo-political situation and recalibrated trade arrangement, it is crucial that India become self-reliant within the generation of APIs and KSMs, which is why decreasing the Import reliance for Active pharmaceutical ingredients (APIs) & Key starting materials (KSMs) particularly from china has been focused upon with the assistance of productive linked incentive scheme (PLIS) passed by Department of pharmaceuticals, Government of India to thrive Indian API industry. Hence, this review highlights the current state of Indian API industry, evaluates challenges, opportunities give suggestions for moving forward for self-sufficiency of APIs as well as centers on current regulatory prerequisites for Active pharmaceutical Ingredients.

APA, Harvard, Vancouver, ISO, and other styles

12

Pylypenko, D. М. "INFLUENCE OF THE LIPID COMPOSITION ON THE PROPERTIES, TECHNOLOGY AND QUALITY INDICATORS OF LIPOSOMAL DRUGS." Biotechnologia Acta 15, no. 5 (October 2022): 24–30. http://dx.doi.org/10.15407/biotech15.05.024.

Full text

Abstract:

Liposomal drug delivery system is an example of the use of nanodrugs in medical practice. Encapsulation of active pharmaceutical ingredients in liposomal nanoparticles allows increasing their bioavailability and efficacy. Aim. The article is devoted to the analysis of the lipid composition of liposomal drugs developed in Ukraine, its influence on the choice of technology and control parameters. Results. The lipid compositions of liposomal drugs developed in Ukraine in recent years were reviewed. The advantages and disadvantages of natural phosphatidylcholine as the main membrane-forming lipid were analyzed. Data on the influence of anionic phospholipids and cholesterol in the liposomal membrane composition on the stability of liposomal nanoparticles and the level of active pharmaceutical ingredient encapsulation were given. The main technological stages of obtaining liposomes with hydrophilic and hydrophobic active pharmaceutical ingredients were considered. The main groups of quality indicators of liposomal dosage forms have been determined. Conclusions. The lipid composition determines the structure and physicochemical properties of the lipid membrane, the mechanism and level of active pharmaceutical ingredient encapsulation, which significantly influences the pharmacological efficacy of liposomal drug delivery systems.

APA, Harvard, Vancouver, ISO, and other styles

13

Lebedev, Igor, Anastasia Uvarova, Maria Mochalova, and Natalia Menshutina. "Active Pharmaceutical Ingredients Transportation and Release from Aerogel Particles Processes Modeling." Computation 10, no. 8 (August 12, 2022): 139. http://dx.doi.org/10.3390/computation10080139.

Full text

Abstract:

In this work, active pharmaceutical ingredients release from aerogel particles and active pharmaceutical ingredients transportation processes were investigated. Experimental studies were carried out on the release of various types of active pharmaceutical ingredients from various types of aerogel particles. Release curves were obtained. A hybrid model using the lattice Boltzmann method and a cellular automata approach to simulate the release of active pharmaceutical ingredients from aerogel particles and active pharmaceutical ingredients transport processes is proposed. The proposed model can be used in new drug development, which allows partially replacing full-scale experiments with computational ones, therefore reducing the experimental studies cost.

APA, Harvard, Vancouver, ISO, and other styles

14

Vlasenko, I. O., and L. L. Davtian. "Active pharmaceutical ingredients in dermatological medicines of Ukrainian pharmaceutical market." Farmatsevtychnyi zhurnal, no. 1 (March 18, 2019): 9–19. http://dx.doi.org/10.32352/0367-3057.1.19.01.

Full text

Abstract:

The problem of the diabetic foot is one of the most serious complications of diabetes mellitus. There is still an active search for medicines (drugs) that could be used in the complex treatment of trophic lesions in diabetic foot. The period before the development and launch of the drug into the pharmaceutical market need to make marketing research aimed at ensuring that the future drug is competitive. The purpose of the work was to analyze the market of dermatological drugs for the treatment of trophic ulcers in order to determine the marketing opportunities for domestic producers. The research objects were active pharmaceutical ingredients (APIs), which are part of the dermatological registered drugs in Ukraine. Materials for research were official sources of information about drugs registered in Ukraine. Marketing analytical methods were used. To determine the level of tension between manufacturers and the same product, the coefficient of tension. Number of D preparations registered in Ukraine ‒ 452 trade names (January 2018) was established. Medicines wich prodused by Ukraine are slightly higher (55.3%). In groups D01, D03, D06, D07 and D08 the highest number of APIs is determined, which is 25, 36, 33, 29 and 30, respectively. Part API is contained in the drug in combination with other API. In the D01 group, only a small amount of API ‒ 7 is present in combination with other substances, and in group D02 ‒ 6, certain APIs are part of the combined drug. In preparations of D03 4 API are in combination. In group D06, 12 APIs are contained in combination drugs. Most of the established API groups D07 (13) are found in the drug in combination. In the D08 group, part of the API (8) is part of a combined drug. There is a combination of APIs antiseptic or antimicrobial activity, anti-inflammatory effect, local anesthetic and wound healing effect. According to the results of the calculation of the tension indices between the manufacturers of analogues of drugs in group D, the highest competition (Kvi ≥ 0.800) was observed in the groups D01 and D03 (for 4 drugs with Kvi ≥ 0.800), D06 (3 drugs), D07 (8 drugs), D08 (7 drugs). An analysis of the competitiveness of analogue manufacturers has shown that Ukrainian manufacturers are not sufficiently competing in the production of modern analogues of dermatological drugs.

APA, Harvard, Vancouver, ISO, and other styles

15

Korcok, Davor, Olivera Colic, Nada Trsic-Milanovic, and Bogdan Mitic. "Low moisture starch for improved viability and stability of new Probiotic L. plantarum 299v preparation." Chemical Industry 72, no. 2 (2018): 107–13. http://dx.doi.org/10.2298/hemind170913003k.

Full text

Abstract:

Probiotic pharmaceutical preparations are more and more popular because of the increasing level of evidence of their beneficial effect on human health. The goal of this study was to determine and develop the encapsulated probiotic formulation with the optimal filling amount of active ingredient - Lactobacillus plantarum that would, in combination with other active ingredients: iron, vitamin C and excipient starch, fulfil requirements for therapeutic action while maintaining process parameters? requirements of manufacturing as well. The optimal formulation of a multicomponent probiotic-based formulation that fulfils requirements for sustaining all active ingredients while respecting technological process requirements, will enable a routine pharmaceutical manufacturing that could yield both efficient and safe dietary products.

APA, Harvard, Vancouver, ISO, and other styles

16

Pagels, Fernando, Cíntia Almeida, Vitor Vasconcelos, and A. Catarina Guedes. "Cosmetic Potential of Pigments Extracts from the Marine Cyanobacterium Cyanobium sp." Marine Drugs 20, no. 8 (July 27, 2022): 481. http://dx.doi.org/10.3390/md20080481.

Full text

Abstract:

The current mindset in the cosmetics market about sustainable ingredients had increased the search for new sources of natural active ingredients. Cyanobacteria are a great source of functional ingredients for cosmetics, as a producer of pigments with described bioactive potential (carotenoids and phycobiliproteins). This work aimed to evaluate the cosmetic potential of marine cyanobacterium Cyanobium sp. pigment-targeted extracts (carotenoids and phycobiliproteins), evaluating their in vitro safety through cytotoxicity assays, cosmetic-related enzyme inhibition, ingredient stability, and putative product (serum formulation). Results showed no cytotoxicity from the extracts in skin-related cell lines. Carotenoid extract showed anti-hyaluronidase capacity (IC50 = 108.74 ± 5.74 mg mL−1) and phycobiliprotein extract showed anti-hyaluronidase and anti-collagenase capacity (IC50 = 67.25 ± 1.18 and 582.82 ± 56.99 mg mL−1, respectively). Regarding ingredient and serum stability, both ingredients showed higher stability at low-temperature conditions, and it was possible to maintain the pigment content and bioactive capacity stable during the tested period, although in higher temperatures the product was degraded in a week. As a major conclusion, both extracts can be potential natural and sustainable ingredients for cosmetic uses, with relatively simple formulation and storage, and can be promising natural anti-aging ingredients due to their bioactive capacity.

APA, Harvard, Vancouver, ISO, and other styles

17

Motoyama, Keiichi. "Potential of Cyclodextrin as Active Pharmaceutical Ingredients." Drug Delivery System 32, no. 5 (2017): 430–31. http://dx.doi.org/10.2745/dds.32.430.

Full text

APA, Harvard, Vancouver, ISO, and other styles

18

Štejfa, Vojtěch, Václav Pokorný, Alex Mathers, Květoslav Růžička, and Michal Fulem. "Heat capacities of selected active pharmaceutical ingredients." Journal of Chemical Thermodynamics 163 (December 2021): 106585. http://dx.doi.org/10.1016/j.jct.2021.106585.

Full text

APA, Harvard, Vancouver, ISO, and other styles

19

Miller, Andrew D. "Precision active pharmaceutical ingredients are the goal." Future Medicinal Chemistry 8, no. 11 (July 2016): 1209–38. http://dx.doi.org/10.4155/fmc-2016-0046.

Full text

APA, Harvard, Vancouver, ISO, and other styles

20

Ferlin, Francesco, Daniela Lanari, and Luigi Vaccaro. "Sustainable flow approaches to active pharmaceutical ingredients." Green Chemistry 22, no. 18 (2020): 5937–55. http://dx.doi.org/10.1039/d0gc02404j.

Full text

Abstract:

This review summarizes the adoption of flow technology for the synthesis of a variety of APIs in the period 2015–2020. A major attention has been dedicated to compare batch and flow procedures by also comparing their sustainability.

APA, Harvard, Vancouver, ISO, and other styles

21

Jasper, J. P., B. J. Westenberger, J. A. Spencer, L. F. Buhse, and M. Nasr. "Stable isotopic characterization of active pharmaceutical ingredients." Journal of Pharmaceutical and Biomedical Analysis 35, no. 1 (April 2004): 21–30. http://dx.doi.org/10.1016/s0731-7085(03)00581-8.

Full text

APA, Harvard, Vancouver, ISO, and other styles

22

Arenas-García, Jenniffer I., Dea Herrera-Ruiz, Karina Mondragón-Vásquez, Hugo Morales-Rojas, and Herbert Höpfl. "Co-Crystals of Active Pharmaceutical Ingredients - Acetazolamide." Crystal Growth & Design 10, no. 8 (August 4, 2010): 3732–42. http://dx.doi.org/10.1021/cg1005693.

Full text

APA, Harvard, Vancouver, ISO, and other styles

23

Bitterlich, André, Christina Laabs, Eike Busmann, Arnaud Grandeury, Michael Juhnke, Heike Bunjes, and Arno Kwade. "Challenges in Nanogrinding of Active Pharmaceutical Ingredients." Chemical Engineering & Technology 37, no. 5 (April 3, 2014): 840–46. http://dx.doi.org/10.1002/ceat.201300697.

Full text

APA, Harvard, Vancouver, ISO, and other styles

24

Brettmann, Blair Kathryn, Kamyu Cheng, Allan S. Myerson, and Bernhardt L. Trout. "Electrospun Formulations Containing Crystalline Active Pharmaceutical Ingredients." Pharmaceutical Research 30, no. 1 (August 25, 2012): 238–46. http://dx.doi.org/10.1007/s11095-012-0868-4.

Full text

APA, Harvard, Vancouver, ISO, and other styles

25

Dogan, Berna, Julian Schneider, and Karsten Reuter. "In silico dissolution rates of pharmaceutical ingredients." Chemical Physics Letters 662 (October 2016): 52–55. http://dx.doi.org/10.1016/j.cplett.2016.09.020.

Full text

APA, Harvard, Vancouver, ISO, and other styles

26

Herrmann, Michael, Ulrich Förter-Barth, Hartmut Kröber, Paul Bernd Kempa, Maria del Mar Juez-Lorenzo, and Stephen Doyle. "Co-Crystallization and Characterization of Pharmaceutical Ingredients." Particle & Particle Systems Characterization 26, no. 3 (September 2009): 151–56. http://dx.doi.org/10.1002/ppsc.200800046.

Full text

APA, Harvard, Vancouver, ISO, and other styles

27

Salahshour, Babak, Sajjad Sadeghi, Hajar Nazari, and Kambiz Soltaninejad. "Determining Undeclared Synthetic Pharmaceuticals as Adulterants in Weight Loss Herbal Medicines." International Journal of Medical Toxicology and Forensic Medicine 10, no. 1 (March 19, 2020): 26253. http://dx.doi.org/10.32598/ijmtfm.v10i1.26253.

Full text

Abstract:

Background: The popularity and use of herbal medicines and supplements are growing worldwide. Herbal anti-obesity products have been considered as suitable alternatives to synthetic pharmaceuticals as they are introduced as harmless natural products. However, some manufacturers often add undeclared synthetic pharmaceuticals to the anti-obesity herbal medicine products to improve their efficacy and potency. The present study aimed to analyze herbal weight loss products collected from the drug market in Bojnurd City, Iran.Methods: Ninety-six herbal drug samples, as weight loss products, were obtained from herb shops and pharmacies in Bojnurd City, Iran. All samples were analyzed to detect undeclared active pharmaceutical ingredients using High-Performance Liquid Chromatography with Diode Array Detector (HPLC-DAD) and Gas Chromatography-Mass Spectrometry (GC-MS) techniques.Results: Caffeine, trimethoxyamphetamine, and vitamin E were identified in herbal weight loss products. Caffeine was detected in 21.8% of the obtained samples, as the most common undeclared active pharmaceutical adulterant. Conclusion: Undeclared active pharmaceutical ingredients in herbal weight loss products could threaten patients’ health. Thus, it is necessary to create awareness through health authorities in this regard.

APA, Harvard, Vancouver, ISO, and other styles

28

Desai, Meghana, Anuli Njoku, and Lillian Nimo-Sefah. "Comparing Environmental Policies to Reduce Pharmaceutical Pollution and Address Disparities." International Journal of Environmental Research and Public Health 19, no. 14 (July 7, 2022): 8292. http://dx.doi.org/10.3390/ijerph19148292.

Full text

Abstract:

Pharmaceutical products, including active pharmaceutical ingredients and inactive ingredients such as packaging materials, have raised significant concerns due to their persistent input and potential threats to human and environmental health. Discourse on reducing pharmaceutical waste and subsequent pollution is often limited, as information about the toxicity of pharmaceuticals in humans is yet to be fully established. Nevertheless, there is growing awareness about ecotoxicity, and efforts to curb pharmaceutical pollution in the European Union (EU), United States (US), and Canada have emerged along with waste disposal and treatment procedures, as well as growing concerns about impacts on human and animal health, such as through antimicrobial resistance. Yet, the outcomes of such endeavors are often disparate and involve multiple agencies, organizations, and departments with little evidence of cooperation, collaboration, or oversight. Environmental health disparities occur when communities exposed to a combination of poor environmental quality and social inequities experience more sickness and disease than wealthier, less polluted communities. In this paper, we discuss pharmaceutical environmental pollution in the context of health disparities and examine policies across the US, EU, and Canada in minimizing environmental pollution.

APA, Harvard, Vancouver, ISO, and other styles

29

Abbas, Ahmed Jasim, Ahmed Issa, Dhamia Abas, Nagham Jasim, Luma Mohammed, and Ban Abdul-latif. "Preparation of Pharmaceutical Formula of Rafoxanide and Levamisole 6% Suspension as Pilot Production." Iraqi Journal of Industrial Research 8, no. 1 (June 14, 2021): 73–77. http://dx.doi.org/10.53523/ijoirvol8i1id42.

Full text

Abstract:

A 100 litter of pharmaceutical formula of veterinary drug Rafoxanide and Levamisole with 6% suspension as pilot production was prepared. The formula contains two active ingredients with a broad spectrum anthelmintic activity. Rafoxanide belong belongs to salicylanilide group used for treatment and control of mature and immature liver flukes in cattle, sheep and goats. Levamisole belongs to Bezimidazole compounds and is active against gastrointestinal worms and against lung worms in cattle, sheep and goats. The drug formula is a white color suspension prepared according to scientific literature. Information was collected for all substances in the formulation for active ingredient ingredients and additives. The chemical assay was carried out on the active ingredients and the final formula and the results showed that they conform to the constitutional specifications. The results of the chemical assay of Rafoxanide (102.7%) and levamisole (101%) were found to be within the approved constitutional limits (90-110%) with the adoption of the results of stability study at temperatures (40, 50, 60 °C). The stability of the pharmaceutical formula was observed within the permissible constitutional limits.

APA, Harvard, Vancouver, ISO, and other styles

30

Rafael, Bence, Nóra Kuruczleki, and József Gál. "The way of the pharmaceutical ingredients to the finished pharmaceutical form." Analecta Technica Szegedinensia 12, no. 2 (December 5, 2018): 24–31. http://dx.doi.org/10.14232/analecta.2018.2.24-31.

Full text

Abstract:

The modern pharmaceutical industry is a strictly controlled area. Both national and international rules apply, but none of these deals with logistical issues arising from the manufacture of the product. Following the path of a drug, it is possible to get acquainted with the problems that arise and their solution. The drug is much more than a common product. The drug is a product of confidence, which is provided with information. It defines its quality as well, to comply with the relevant directives and standards in the manufacture of, and that the enclosed information is sent to the user. This requires the manufacturer, the distributor and the user to comply with it. There is no production without material handling, but GMP (Good Manufacturing Practice) does not yet have a chapter on logistics. References to handling raw materials and finished products can be found in the corresponding GMP chapters, the responsibility of the correct execution are borne by the manufacturer. In this case, the effect of the common sense prevails exponentially, keep the medicine in mind and it has to be done, that no loss, no quality deterioration is not caused by the transport, handling of such loads, storage. It is typical that the raw material and the finished product are going through the entire site during the pharmaceutical manufacture. Starting from the warehouse, it runs through the manufacturing facilities, on the packaging, and some units go to the lab, so that eventually, in medicine form returns to the warehouse, from where it goes further in the supply chain through the pharmacies to the patients. In our study we examine the logistics activity and problems of a small pharmaceutical company and tasks to be solved presented in the light of the theory.

APA, Harvard, Vancouver, ISO, and other styles

31

Atwood, Jerry L. "Separation of Active Pharmaceutical Ingredients (APIs) from Excipients in Pharmaceutical Formulations." Crystal Growth & Design 15, no. 6 (April 28, 2015): 2874–77. http://dx.doi.org/10.1021/acs.cgd.5b00317.

Full text

APA, Harvard, Vancouver, ISO, and other styles

32

Vishweshwar, Peddy, Jennifer A. McMahon, Matthew L. Peterson, Magali B. Hickey, Tanise R. Shattock, and Michael J. Zaworotko. "Crystal engineering of pharmaceutical co-crystals from polymorphic active pharmaceutical ingredients." Chemical Communications, no. 36 (2005): 4601. http://dx.doi.org/10.1039/b501304f.

Full text

APA, Harvard, Vancouver, ISO, and other styles

33

Siahaan, Evi Amelia, Agusman, Ratih Pangestuti, Kyung-Hoon Shin, and Se-Kwon Kim. "Potential Cosmetic Active Ingredients Derived from Marine By-Products." Marine Drugs 20, no. 12 (November 24, 2022): 734. http://dx.doi.org/10.3390/md20120734.

Full text

Abstract:

The market demand for marine-based cosmetics has shown a tremendous growth rate in the last decade. Marine resources represent a promising source of novel bioactive compounds for new cosmetic ingredient development. However, concern about sustainability also becomes an issue that should be considered in developing cosmetic ingredients. The fisheries industry (e.g., fishing, farming, and processing) generates large amounts of leftovers containing valuable substances, which are potent sources of cosmeceutical ingredients. Several bioactive substances could be extracted from the marine by-product that can be utilized as a potent ingredient to develop cosmetics products. Those bioactive substances (e.g., collagen from fish waste and chitin from crustacean waste) could be utilized as anti-photoaging, anti-wrinkle, skin barrier, and hair care products. From this perspective, this review aims to approach the potential active ingredients derived from marine by-products for cosmetics and discuss the possible activity of those active ingredients in promoting human beauty. In addition, this review also covers the prospect and challenge of using marine by-products toward the emerging concept of sustainable blue cosmetics.

APA, Harvard, Vancouver, ISO, and other styles

34

Wathoni, Nasrul, Wuri Ariestika Sari, Khaled M. Elamin, Ahmed Fouad Abdelwahab Mohammed, and Ine Suharyani. "A Review of Coformer Utilization in Multicomponent Crystal Formation." Molecules 27, no. 24 (December 8, 2022): 8693. http://dx.doi.org/10.3390/molecules27248693.

Full text

Abstract:

Most recently discovered active pharmaceutical molecules and market-approved medicines are poorly soluble in water, resulting in limited drug bioavailability and therapeutic effectiveness. The application of coformers in a multicomponent crystal method is one possible strategy to modulate a drug’s solubility. A multicomponent crystal is a solid phase formed when several molecules of different substances crystallize in a crystal lattice with a certain stoichiometric ratio. The goal of this review paper is to comprehensively describe the application of coformers in the formation of multicomponent crystals as solutions for pharmaceutically active ingredients with limited solubility. Owing to their benefits including improved physicochemical profile of pharmaceutically active ingredients, multicomponent crystal methods are predicted to become increasingly prevalent in the development of active drug ingredients in the future

APA, Harvard, Vancouver, ISO, and other styles

35

Grigorov, Plamen I., Benjamin J. Glasser, and Fernando J. Muzzio. "Improving dissolution kinetics of pharmaceuticals by fluidized bed impregnation of active pharmaceutical ingredients." AIChE Journal 62, no. 12 (June 8, 2016): 4201–14. http://dx.doi.org/10.1002/aic.15312.

Full text

APA, Harvard, Vancouver, ISO, and other styles

36

Thakur, Rajan, and Anjana Devi. "Sensor Applications in Analysis of Drugs and Formulations." INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH 6, no. 04 (October 1, 2021): 57–62. http://dx.doi.org/10.21477/ijapsr.6.4.03.

Full text

Abstract:

Biosensors are currently widely used in biomedical diagnostics, as well as point-of-care assessment of therapy and disease advancement, environmental sensing, food safety, drug development, forensics, and biomedical research. Biosensors may be developed using several different approaches. Due to the growing requirement for efficient and low-cost analytical methods, biosensors have gained increasing attention for application in the quality analysis of pharmaceuticals and other pharmaceutically relevant analytes. Biosensors enable the analysis of active ingredients in pharmaceutical formulations as well as the determination of degraded products and intermediates in biological matrices. The current study discusses several types of biosensors and their applications in drug analysis and formulations.

APA, Harvard, Vancouver, ISO, and other styles

37

Paczkowska, Magdalena, and Judyta Cielecka-Piontek. "Cyclodextrins as multifunctional excipients." Postępy Polskiej Medycyny i Farmacji 6 (May 8, 2019): 67–76. http://dx.doi.org/10.5604/01.3001.0013.2319.

Full text

Abstract:

Cyclodextrins are pharmaceutical excipients which can form inclusion complexes. They are mainly used to increase the solubility of active pharmaceutical ingredients, which causes increased bioavailability. In addition, they can mask the taste and smell, affect the modification of biological properties and increase its chemical stability. The aim of the studies was to determine the possibility of using cyclodextrins as substances modifying chemical stability of model labile active pharmaceutical ingredients for which the susceptibility to degradation in acid-base hydrolysis (meropenem), thermolysis (meropenem), oxidation (cetirizine) or photolysis (rutin) has been previously proven. The extension of the research was a parallel assessment of the effect of cyclodextrin on selected physicochemical and biological properties important due to the possibility of modifying the pharmaceutical properties of selected model labile active pharmaceutical ingredients. In the first stage, preparations of labile systems of active pharmaceutical ingredients with β-cyclodextrin were carried out using kneading and dry mixing methods. Next, the identity of the obtained systems was confirmed using spectral (UV, FT-IR, Raman, XRPD), thermal (DSC) and microscopic (SEM) methods. The analytical methods (UV method for meropenem, HILIC for cetirizine and UHPLC-DAD for rutin) have been developed and validated to assess the changes in the concentration of model labile active pharmaceutical ingredients during stability, solubility and permeability studies through artificial biological membranes. The conducted research confirms the possibility of modifying the chemical stability of labile active pharmaceutical ingredients under acid- -base hydrolysis conditions, thermolysis, oxidation and photolysis. They also confirm the beneficial effect of the presence of inclusion systems based on cyclodextrin systems on parameters for other pharmaceutical properties of active substances, especially such as dissolution dynamics, dissolution rate, permeability and eventually bioavailability.

APA, Harvard, Vancouver, ISO, and other styles

38

Wang, Na, Chuang Xie, Haijiao Lu, Nannan Guo, Yajing Lou, Weiyi Su, and Hongxun Hao. "Cocrystal and its Application in the Field of Active Pharmaceutical Ingredients and Food Ingredients." Current Pharmaceutical Design 24, no. 21 (October 15, 2018): 2339–48. http://dx.doi.org/10.2174/1381612824666180522102732.

Full text

Abstract:

Background: The development of solid drug dosage form and food ingredients is constrained by their low solubility, low dissolution, low bioavailability and poor physicochemical properties. Formation of cocrystal is a novel and promising method to enhance and improve the properties of materials without breaking the covalent bonds. Methods: The goal of this review is to summarize the cocrystals and their applications in the field of Active Pharmaceutical Ingredients (APIs) and food ingredients (AFIs), mainly on the effective improvements of APIs’ and AFIs’ pharmacokinetic, physicochemical and mechanical properties by the formation of cocrystals. Results: After years of research and development on cocrystals in the area of pharmaceutical and food industries, significant progress has been made. Formation of cocrystal is an efficient method for improving the solubility, dissolution rate, permeability and in vivo bioavailability of APIs and AFIs, as well as for enhancing stability and mechanical properties. Conclusion: Cocrystals exhibit complex structures which can conspicuously affect the physical and chemical properties of original substance, with good clinical performance and outstanding stability during processing and storage.

APA, Harvard, Vancouver, ISO, and other styles

39

Miedinger, David. "Handling of highly active pharmaceutical ingredients and intermediates in the pharmaceutical industry." Safety and Health at Work 13 (January 2022): S39. http://dx.doi.org/10.1016/j.shaw.2021.12.841.

Full text

APA, Harvard, Vancouver, ISO, and other styles

40

Bharate, Sonali S., Sandip B. Bharate, and Amrita N. Bajaj. "ChemInform Abstract: Interactions and Incompatibilities of Pharmaceutical Excipients with Active Pharmaceutical Ingredients." ChemInform 42, no. 47 (October 27, 2011): no. http://dx.doi.org/10.1002/chin.201147271.

Full text

APA, Harvard, Vancouver, ISO, and other styles

41

Šimek, Michal, Jan Vyňuchal, and Lea Tomášová. "Salt-kneading: alternative sizing of active pharmaceutical ingredients?" Pharmaceutical Development and Technology 21, no. 8 (September 12, 2015): 972–79. http://dx.doi.org/10.3109/10837450.2015.1086371.

Full text

APA, Harvard, Vancouver, ISO, and other styles

42

Lu, Jie, and Sohrab Rohani. "Polymorphism and Crystallization of Active Pharmaceutical Ingredients (APIs)." Current Medicinal Chemistry 16, no. 7 (March 1, 2009): 884–905. http://dx.doi.org/10.2174/092986709787549299.

Full text

APA, Harvard, Vancouver, ISO, and other styles

43

Sharma, Rahul, and Gautam Setia. "Enhancing flowability of fine cohesive active pharmaceutical ingredients." Drug Development and Industrial Pharmacy 47, no. 7 (July 3, 2021): 1140–52. http://dx.doi.org/10.1080/03639045.2021.1988093.

Full text

APA, Harvard, Vancouver, ISO, and other styles

44

Babić, Sandra, Alka J. M. Horvat, Dragana Mutavdžić Pavlović, and Marija Kaštelan-Macan. "Determination of pKa values of active pharmaceutical ingredients." TrAC Trends in Analytical Chemistry 26, no. 11 (December 2007): 1043–61. http://dx.doi.org/10.1016/j.trac.2007.09.004.

Full text

APA, Harvard, Vancouver, ISO, and other styles

45

Kątny, M., and M. Frankowski. "Impurities in Drug Products and Active Pharmaceutical Ingredients." Critical Reviews in Analytical Chemistry 47, no. 3 (November 1, 2016): 187–93. http://dx.doi.org/10.1080/10408347.2016.1242401.

Full text

APA, Harvard, Vancouver, ISO, and other styles

46

Brinkmann, Joscha, Frauke Rest, Christian Luebbert, and Gabriele Sadowski. "Solubility of Pharmaceutical Ingredients in Natural Edible Oils." Molecular Pharmaceutics 17, no. 7 (May 5, 2020): 2499–507. http://dx.doi.org/10.1021/acs.molpharmaceut.0c00215.

Full text

APA, Harvard, Vancouver, ISO, and other styles

47

Šupuk, Enes, Afsheen Zarrebini, Jay P. Reddy, Helen Hughes, Michael M. Leane, Mike J. Tobyn, Peter Timmins, and Mojtaba Ghadiri. "Tribo-electrification of active pharmaceutical ingredients and excipients." Powder Technology 217 (February 2012): 427–34. http://dx.doi.org/10.1016/j.powtec.2011.10.059.

Full text

APA, Harvard, Vancouver, ISO, and other styles

48

Soto, Jessica, Alexander Keeley, Alison V. Keating, Abeer H. A. Mohamed-Ahmed, Yucheng Sheng, Gesine Winzenburg, Roy Turner, Sabine Desset-Brèthes, Mine Orlu, and Catherine Tuleu. "Rats can predict aversiveness of Active Pharmaceutical Ingredients." European Journal of Pharmaceutics and Biopharmaceutics 133 (December 2018): 77–84. http://dx.doi.org/10.1016/j.ejpb.2018.09.027.

Full text

APA, Harvard, Vancouver, ISO, and other styles

49

Pallotta, Arnaud, Ariane Boudier, Benjamin Creusot, Emilie Brun, Cécile Sicard-Roselli, Rana Bazzi, Stéphane Roux, and Igor Clarot. "Quality control of gold nanoparticles as pharmaceutical ingredients." International Journal of Pharmaceutics 569 (October 2019): 118583. http://dx.doi.org/10.1016/j.ijpharm.2019.118583.

Full text

APA, Harvard, Vancouver, ISO, and other styles

50

Fabian, Arthur C. "Principles for Effective Regulatory Active Pharmaceutical Ingredients Policy." Drug Information Journal 33, no. 3 (July 1999): 747–53. http://dx.doi.org/10.1177/009286159903300313.

Full text

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!