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Relevant bibliographies by topics / Pharmaceutical microbiology

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Dissertations / Theses

Academic literature on the topic 'Pharmaceutical microbiology'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 January 2023

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Dissertations / Theses on the topic "Pharmaceutical microbiology"

1

Macdonald, Niall Patrick. "Microsystems manufacturing technologies for pharmaceutical toxicity testing." Thesis, University of Glasgow, 2013. http://theses.gla.ac.uk/5070/.

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To meet the demands of political, ethical and scientific pressures on animal testing, research into possible alternatives is required. Data obtained with animal models often cannot be related to humans. Testing with current cell-based assays, microdosing and pharmacokinetic models contribute to reducing animal testing and improving the drug development process. Micro-fabrication and rapid prototyping techniques offer potential solutions to reduce the need for animal toxicity testing. The aim of this research was to develop biological platforms for in vitro toxicity testing to provide physiolog

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2

Saiz, Balbastre Sandra. "Development and application of analytical techniques for quality control of biologics and sterile pharmaceutical products." Doctoral thesis, Universitat Autònoma de Barcelona, 2019. http://hdl.handle.net/10803/666802.

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El control microbiològic és essencial en la indústria farmacèutica ja que es tracta d’un indicador de la seguretat dels productes. Els mètodes microbiològics utilitzats a les companyies farmacèutiques per analitzar l’ambient del procés de fabricació així com els productes finals estan basats en mètodes de cultiu tradicional. La tecnologia d’aquests mètodes manca de precisió comparada amb les tecnologies més modernes de detecció i identificació microbiològica. Cada vegada, els requeriments dels controls microbiològics de productes i processos són més estrictes, el que fa que es necessiten mèto

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3

Pretorius, Erina. "Determination of the permeability of biological membranes to various chemical markers, including anti-HIV drugs." Thesis, Stellenbosch : University of Stellenbosch, 2009. http://hdl.handle.net/10019.1/1289.

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Thesis (PhD (Pathology. Medical Microbiology))--University of Stellenbosch, 2009.<br>ENGLISH ABSTRACT: Due to modern high-throughput technologies, large numbers of compounds are produced by parallel synthesis and combinatorial chemistry. The pharmaceutical industry therefore requires rapid and accurate methods to screen new drugs leads for membrane permeability potential in the early stages of drug discovery. Around 50 % of all investigational new drugs fail in pre-clinical and clinical phases of development due to inadequate absorption/permeation, distribution, metabolism, excretion and/

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4

Simon, Remil B. S., Darshan M. D. Shah, Peter B. S. Blosser, Demetrio M. D. Macariola, and Jeffrey M. D. Carlsen. "Treatment of CMV Vitritis in a Preterm Newborn." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/asrf/2018/schedule/165.

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Title: Treatment of CMV Vitritis in a Preterm Newborn Author’s Section: Remil Simon1, Darshan Shah1, Peter Blosser1, Demetrio Macariola1, Jeffrey Carlsen2 1.Department of Pediatrics, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 2.Johnson City Eye Clinic, Johnson City, TN Body: Cytomegalovirus (CMV) infection in the neonate is an infrequent occurrence in the developing world, and observing the symptoms of ocular CMV infection such as vitritis is rare. Treating CMV infection promptly is necessary to prevent mortality and potential neurological deficits including

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5

Gavva, Shravan. "Single Step Synthesis of Antibiotic Kanamycin Embedded Gold Nanoparticles for Efficient Antibacterial Activity." TopSCHOLAR®, 2013. http://digitalcommons.wku.edu/theses/1282.

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Nanotechnology has become the most advanced type of drug delivery system within the last decade. This advancement shifted the focus on small carriers to increase the efficiency of the drugs. Among these, gold nanoparticles (GNPs) were found to have profound biomedical applications. In current research, kanamycin embedded GNPs were prepared in a single step, single phase, and bio-friendly (green synthesis) procedure. The synthesized Kanamycin-GNPs (Kan-GNPs) were spherical in shape and had a size range of 15 ± 3 nm. The chosen kanamycin is an aminoglycosidic antibiotic that is isolated from Str

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6

Zarins-Tutt, Joseph Scott. "Gene mining of biosynthesis genes and biosynthetic manipulation of marine bacteria for the production of new antibiotic candidates." Thesis, University of St Andrews, 2015. http://hdl.handle.net/10023/7690.

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Natural product drug discovery has traditionally been the corner stone of medicine having provided cures to many of today's most common diseases. In particular, antibiotics have revolutionised healthcare and extended human lifespan. However, since their introduction into the clinic, resistance to these drugs has arisen. With the number of new antibiotics being discovered in recent years declining, and fewer drugs making it past clinical trials, we have reached the point where antibiotic resistant infections have become common place and a serious threat to health and society. There is now an ur

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7

Holbrook, Selina Y. L. "DISCOVERY OF NEW ANTIMICROBIAL OPTIONS AND EVALUATION OF AMINOGLYCOSIDE RESISTANCE ENZYME-ASSOCIATED RESISTANCE EPIDEMIC." UKnowledge, 2018. https://uknowledge.uky.edu/pharmacy_etds/89.

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The extensive and sometimes incorrect and noncompliant use of various types of antimicrobial agents has accelerated the development of antimicrobial resistance (AMR). In fact, AMR has become one of the greatest global threat to human health in this era. The broad-spectrum antibiotics aminoglycosides (AGs) display excellent potency against most Gram-negative bacteria, mycobacteria, and some Gram-positive bacteria, such as Staphylococcus aureus. The AG antibiotics amikacin, gentamicin, kanamycin, and tobramycin are still commonly prescribed in the U.S.A. for the treatment of serious infections.

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8

Garcia, Subirats Maria. "Disseny, síntesi i avaluació biològica i biofísica d’anàlegs de polimixina." Doctoral thesis, Universitat de Barcelona, 2015. http://hdl.handle.net/10803/379552.

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El problema de la resistència bacteriana ha esdevingut un problema de salut pública global. Cada cop apareixen més soques bacterianes resistents a dos o més fàrmacs i és especialment preocupant la manca d'antibiòtics en el mercat per a combatre les infeccions que aquests provoquen. És per això que un dels grans objectius del descobriment de nous fàrmacs antibiòtics és la recerca de nous compostos capaços de combatre aquests microorganismes. Els pèptids antimicrobians són una classe d'antibiòtics que en el darrers anys han despertat interès degut al seu particular mecanisme d'acció: actuen prin

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9

Serviant-Fine, Thibaut. "Une approche rationnelle de la chimiothérapie : histoire des antimétabolites (1935-1955)." Thesis, Lyon, 2016. http://www.theses.fr/2016LYSE1271/document.

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En 1940, le biochimiste anglais Donald Woods propose une explication du mode d'action des nouveaux sulfamides antibactériens : l'inhibition compétitive. Son collègue Paul Fildes fonde sur cette base une nouvelle approche de la chimiothérapie, revendiquée comme rationnelle, un programme pour la recherche de nouveaux médicaments. Cette thèse explore l'impact de la théorie des antimétabolites, comme elle sera appelée, dans la recherche biochimique et pharmaceutique. La première partie retrace son élaboration dans le contexte de l'école de biochimie anglaise, puis sa reprise aux États-Unis à la su

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10

Harris, Michelle J. "Characterization of Drug Resistance in Mycobacterium Tuberculosis via Saturating Mutagenesis of Drug Targets: A Master’s Thesis." eScholarship@UMMS, 2012. https://escholarship.umassmed.edu/gsbs_diss/605.

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Mycobacterium tuberculosis isolates from multiple drug resistant or extensively drug resistant patients show a particular set of mutations in drug targets conferring resistance. However, the selection of drug-resistant strains in vitro yields an alternative set of mutations, thought to result from the cost-benefit associated with drug resistance. Mutations allowing for survival under antibiotic may not be beneficial when presented with the host environment or with a drug-free environment. These fitness effects drive the natural evolution of this bacterium. Using recombineering a large cohor

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