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Relevant bibliographies by topics / Pharmaceutical microbiology / Dissertations / Theses

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Dissertations / Theses on the topic 'Pharmaceutical microbiology'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 January 2023

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1

Macdonald, Niall Patrick. "Microsystems manufacturing technologies for pharmaceutical toxicity testing." Thesis, University of Glasgow, 2013. http://theses.gla.ac.uk/5070/.

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To meet the demands of political, ethical and scientific pressures on animal testing, research into possible alternatives is required. Data obtained with animal models often cannot be related to humans. Testing with current cell-based assays, microdosing and pharmacokinetic models contribute to reducing animal testing and improving the drug development process. Micro-fabrication and rapid prototyping techniques offer potential solutions to reduce the need for animal toxicity testing. The aim of this research was to develop biological platforms for in vitro toxicity testing to provide physiolog

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2

Saiz, Balbastre Sandra. "Development and application of analytical techniques for quality control of biologics and sterile pharmaceutical products." Doctoral thesis, Universitat Autònoma de Barcelona, 2019. http://hdl.handle.net/10803/666802.

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El control microbiològic és essencial en la indústria farmacèutica ja que es tracta d’un indicador de la seguretat dels productes. Els mètodes microbiològics utilitzats a les companyies farmacèutiques per analitzar l’ambient del procés de fabricació així com els productes finals estan basats en mètodes de cultiu tradicional. La tecnologia d’aquests mètodes manca de precisió comparada amb les tecnologies més modernes de detecció i identificació microbiològica. Cada vegada, els requeriments dels controls microbiològics de productes i processos són més estrictes, el que fa que es necessiten mèto

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3

Pretorius, Erina. "Determination of the permeability of biological membranes to various chemical markers, including anti-HIV drugs." Thesis, Stellenbosch : University of Stellenbosch, 2009. http://hdl.handle.net/10019.1/1289.

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Thesis (PhD (Pathology. Medical Microbiology))--University of Stellenbosch, 2009.<br>ENGLISH ABSTRACT: Due to modern high-throughput technologies, large numbers of compounds are produced by parallel synthesis and combinatorial chemistry. The pharmaceutical industry therefore requires rapid and accurate methods to screen new drugs leads for membrane permeability potential in the early stages of drug discovery. Around 50 % of all investigational new drugs fail in pre-clinical and clinical phases of development due to inadequate absorption/permeation, distribution, metabolism, excretion and/

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4

Simon, Remil B. S., Darshan M. D. Shah, Peter B. S. Blosser, Demetrio M. D. Macariola, and Jeffrey M. D. Carlsen. "Treatment of CMV Vitritis in a Preterm Newborn." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/asrf/2018/schedule/165.

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Title: Treatment of CMV Vitritis in a Preterm Newborn Author’s Section: Remil Simon1, Darshan Shah1, Peter Blosser1, Demetrio Macariola1, Jeffrey Carlsen2 1.Department of Pediatrics, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 2.Johnson City Eye Clinic, Johnson City, TN Body: Cytomegalovirus (CMV) infection in the neonate is an infrequent occurrence in the developing world, and observing the symptoms of ocular CMV infection such as vitritis is rare. Treating CMV infection promptly is necessary to prevent mortality and potential neurological deficits including

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5

Gavva, Shravan. "Single Step Synthesis of Antibiotic Kanamycin Embedded Gold Nanoparticles for Efficient Antibacterial Activity." TopSCHOLAR®, 2013. http://digitalcommons.wku.edu/theses/1282.

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Nanotechnology has become the most advanced type of drug delivery system within the last decade. This advancement shifted the focus on small carriers to increase the efficiency of the drugs. Among these, gold nanoparticles (GNPs) were found to have profound biomedical applications. In current research, kanamycin embedded GNPs were prepared in a single step, single phase, and bio-friendly (green synthesis) procedure. The synthesized Kanamycin-GNPs (Kan-GNPs) were spherical in shape and had a size range of 15 ± 3 nm. The chosen kanamycin is an aminoglycosidic antibiotic that is isolated from Str

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6

Zarins-Tutt, Joseph Scott. "Gene mining of biosynthesis genes and biosynthetic manipulation of marine bacteria for the production of new antibiotic candidates." Thesis, University of St Andrews, 2015. http://hdl.handle.net/10023/7690.

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Natural product drug discovery has traditionally been the corner stone of medicine having provided cures to many of today's most common diseases. In particular, antibiotics have revolutionised healthcare and extended human lifespan. However, since their introduction into the clinic, resistance to these drugs has arisen. With the number of new antibiotics being discovered in recent years declining, and fewer drugs making it past clinical trials, we have reached the point where antibiotic resistant infections have become common place and a serious threat to health and society. There is now an ur

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7

Holbrook, Selina Y. L. "DISCOVERY OF NEW ANTIMICROBIAL OPTIONS AND EVALUATION OF AMINOGLYCOSIDE RESISTANCE ENZYME-ASSOCIATED RESISTANCE EPIDEMIC." UKnowledge, 2018. https://uknowledge.uky.edu/pharmacy_etds/89.

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The extensive and sometimes incorrect and noncompliant use of various types of antimicrobial agents has accelerated the development of antimicrobial resistance (AMR). In fact, AMR has become one of the greatest global threat to human health in this era. The broad-spectrum antibiotics aminoglycosides (AGs) display excellent potency against most Gram-negative bacteria, mycobacteria, and some Gram-positive bacteria, such as Staphylococcus aureus. The AG antibiotics amikacin, gentamicin, kanamycin, and tobramycin are still commonly prescribed in the U.S.A. for the treatment of serious infections.

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8

Garcia, Subirats Maria. "Disseny, síntesi i avaluació biològica i biofísica d’anàlegs de polimixina." Doctoral thesis, Universitat de Barcelona, 2015. http://hdl.handle.net/10803/379552.

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El problema de la resistència bacteriana ha esdevingut un problema de salut pública global. Cada cop apareixen més soques bacterianes resistents a dos o més fàrmacs i és especialment preocupant la manca d'antibiòtics en el mercat per a combatre les infeccions que aquests provoquen. És per això que un dels grans objectius del descobriment de nous fàrmacs antibiòtics és la recerca de nous compostos capaços de combatre aquests microorganismes. Els pèptids antimicrobians són una classe d'antibiòtics que en el darrers anys han despertat interès degut al seu particular mecanisme d'acció: actuen prin

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9

Serviant-Fine, Thibaut. "Une approche rationnelle de la chimiothérapie : histoire des antimétabolites (1935-1955)." Thesis, Lyon, 2016. http://www.theses.fr/2016LYSE1271/document.

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En 1940, le biochimiste anglais Donald Woods propose une explication du mode d'action des nouveaux sulfamides antibactériens : l'inhibition compétitive. Son collègue Paul Fildes fonde sur cette base une nouvelle approche de la chimiothérapie, revendiquée comme rationnelle, un programme pour la recherche de nouveaux médicaments. Cette thèse explore l'impact de la théorie des antimétabolites, comme elle sera appelée, dans la recherche biochimique et pharmaceutique. La première partie retrace son élaboration dans le contexte de l'école de biochimie anglaise, puis sa reprise aux États-Unis à la su

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10

Harris, Michelle J. "Characterization of Drug Resistance in Mycobacterium Tuberculosis via Saturating Mutagenesis of Drug Targets: A Master’s Thesis." eScholarship@UMMS, 2012. https://escholarship.umassmed.edu/gsbs_diss/605.

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Mycobacterium tuberculosis isolates from multiple drug resistant or extensively drug resistant patients show a particular set of mutations in drug targets conferring resistance. However, the selection of drug-resistant strains in vitro yields an alternative set of mutations, thought to result from the cost-benefit associated with drug resistance. Mutations allowing for survival under antibiotic may not be beneficial when presented with the host environment or with a drug-free environment. These fitness effects drive the natural evolution of this bacterium. Using recombineering a large cohor

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11

Decker, Daniel. "UDP-sugar metabolizing pyrophosphorylases in plants : formation of precursors for essential glycosylation-reactions." Doctoral thesis, Umeå universitet, Institutionen för fysiologisk botanik, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-134087.

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UDP-sugar metabolizing pyrophosphorylases provide the primary mechanism for de novo synthesis of UDP-sugars, which can then be used for myriads of glycosyltranferase reactions, producing cell wall carbohydrates, sucrose, glycoproteins and glycolipids, as well as many other glycosylated compounds. The pyrophosphorylases can be divided into three families: UDP-Glc pyrophosphorylase (UGPase), UDP-sugar pyrophosphorylase (USPase) and UDP-N-acety lglucosamine pyrophosphorylase (UAGPase), which can be discriminated both by differences in accepted substrate range and amino acid sequences. This thesis

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12

Barnard, Sandra H. "Amalgamation of Nucleosides and Amino Acids in Antibiotic Biosynthesis." UKnowledge, 2013. http://uknowledge.uky.edu/pharmacy_etds/20.

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The rapid increase in antibiotic resistance demands the identification of novel antibiotics with novel targets. One potential antibacterial target is the biosynthesis of peptidoglycan cell wall, which is both ubiquitous and necessary for bacterial survival. Both the caprazamycin-related compounds A-90289 and muraminomicin, as well as the capuramycin-related compounds A-503083 and A-102395 are potent inhibitors of the translocase I enzyme, one of the key enzymes required for cell wall biosynthesis. The caprazamycin-related compounds contain a core nonproteinogen b-hydroxy-a-amino acid referred

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13

Houghton, Stephen Richard. "Improving access to biologically and pharmaceutically relevant molecules by understanding mechanisms of biosynthesis and improving chemical synthesis." Related electronic resource: Current Research at SU : database of SU dissertations, recent titles available full text, 2008. http://wwwlib.umi.com/cr/syr/main.

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14

O'Hara, Connor P. "Inhibition of Cancer Stem Cells by Glycosaminoglycan Mimetics." VCU Scholars Compass, 2019. https://scholarscompass.vcu.edu/etd/5989.

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Connor O’Hara July 29, 2019 Inhibition of Cancer Stem Cells by Glycosaminoglycan Mimetics In the United States cancer is the second leading cause of death, with colorectal cancer (CRC) being the third deadliest cancer and expected to cause over 51,000 fatalities in 2019 alone.1 The current standard of care for CRC depends largely on the staging, location, and presence of metastasis.2 As the tumor grows and invades nearby lymph tissue and blood vessels, CRC has the opport

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15

Lopes, da Rosa-Spiegler Jessica. "Targeting the Histone Acetyl-Transferase, RTT109, for Novel Anti-Fungal Drug Development: A Dissertation." eScholarship@UMMS, 2012. https://escholarship.umassmed.edu/gsbs_diss/624.

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Discovery of new antifungal chemo-therapeutics for humans is limited by the large degree of conservation among eukaryotic organisms. In recent years, the histone acetyl-transferase Rtt109 was identified as the sole enzyme responsible for an abundant and important histone modification, histone H3 lysine 56 (H3K56) acetylation. In the absence of Rtt109, the lack of acetylated H3K56 renders yeast cells extremely sensitive to genotoxic agents. Consequently, the ability to sustain genotoxic stress from the host immune system is crucial for pathogens to perpetuate an infection. Because Rtt109 is con

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16

Bunch, Aubrey R. "Abundance of nonprescription pharmaceuticals in central Indiana streams and effects on sediment microbial activity." Muncie, IN : Ball State University, 2009. http://cardinalscholar.bsu.edu/640.

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17

Hill, David Richard. "THE ROLE OF HYALURONAN IN INNATE INTESTINAL DEFENSE." Case Western Reserve University School of Graduate Studies / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=case1364999901.

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18

Kholikov, Khomidkhodzha. "Enhanced Singlet Oxygen Generation and Antimicrobial Activity of Methylene Blue Coupled with Graphene Quantum Dots as an Effective Photodynamic Therapy Agent." TopSCHOLAR®, 2018. https://digitalcommons.wku.edu/theses/3059.

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Growing resistance of bacteria towards antibiotics resulted in extensive research effort for development and application of new materials and techniques. Due to their unique properties, graphene quantum dots (GQDs) have attracted much attention and are a promising material with potential applications in many fields. One use of GQDs is as a photodynamic therapy agent that generates singlet oxygen. In this work, GQDs synthesized by focusing nanosecond laser pulses into a mixture of benzene and nickel(II) oxide were combined with methylene blue (MB) to eradicate Gram-negative Escherichia coli and

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19

Costa, Luciana Veloso da. "Avaliação da diversidade microbiana presente em sistema gerador de água purificada dedicado à produção de penicilínicos em Farmanguinhos - Fiocruz." reponame:Repositório Institucional da FIOCRUZ, 2014. https://www.arca.fiocruz.br/handle/icict/13012.

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Made available in DSpace on 2016-03-04T13:55:12Z (GMT). No. of bitstreams: 2 7.pdf: 2671790 bytes, checksum: 3ea789720d5aa831716c6bfe2ca4f9b6 (MD5) license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5) Previous issue date: 2014<br>Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos/Farmanguinhos. Rio de Janeiro, RJ, Brasil.<br>O Instituto de Tecnologia em Fármacos (Farmanguinhos), unidade técnico-científica da Fundação Oswaldo Cruz, representa o maior laboratório farmacêutico oficial vinculado ao Ministério da Saúde brasileiro responsável pela produção de mais de u

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20

Morris, Daniel L. "NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY IN THE STUDY OF PROTEIN-LIGAND INTERACTIONS." University of Akron / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=akron1524681449524557.

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21

Senkowski, Wojciech. "High-throughput screening using multicellular tumor spheroids to reveal and exploit tumor-specific vulnerabilities." Doctoral thesis, Uppsala universitet, Cancerfarmakologi och beräkningsmedicin, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-320598.

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High-throughput drug screening (HTS) in live cells is often a vital part of the preclinical anticancer drug discovery process. So far, two-dimensional (2D) monolayer cell cultures have been the most prevalent model in HTS endeavors. However, 2D cell cultures often fail to recapitulate the complex microenvironments of in vivo tumors. Monolayer cultures are highly proliferative and generally do not contain quiescent cells, thought to be one of the main reasons for the anticancer therapy failure in clinic. Thus, there is a need for in vitro cellular models that would increase predictive value of

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22

Blanpain, Baptiste. "Vers un calcul en temps réel de la dose dans un fantôme segmenté en mailles homogènes." Phd thesis, Université Paul Sabatier - Toulouse III, 2009. http://tel.archives-ouvertes.fr/tel-00452891.

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La planification automatique des traitements de radiothérapie n´ecessite un calcul très rapide de la dose délivrée au patient. Nous proposons de réaliser ce calcul en segmentant le fantôme du patient en mailles homogènes, et en associant aux mailles des projections vers des distributions précalculées en milieux homogènes, ainsi que des pondérations gérant les hétérogénéités. Le calcul de dose se fait en deux étapes. La première étape concerne les mailles : les projections et pondérations y sont paramétrées en fonction de critères physiques et géométriques. La seconde étape concerne les voxels

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23

Osama, Mohammad. "Function of Vascular Endothelial Cells in Aging and Hypothermia: Clinical Implications." Ohio University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1534939514503588.

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24

Mocktar, Chunderika. "Antimicrobial and chemical analyses of selected bulbine species." Thesis, 2000. http://hdl.handle.net/10413/4585.

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The use of plant materials for the treatment of various diseases is very common in African countries. As traditional medicine used by the rural people does not always have a proper scientific basis, research programmes have to be undertaken to evaluate their therapeutic efficacy and safety. In traditional African medicine various Bulbine species are used to treat a number of conditions including sexually transmitted diseases, wound infections, dysentery and urinary tract infections. The Bulbine species belong to the family Asphodelaceae. There are over fifty South African Bulbine species and t

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25

"External differential representation and its application to Spectinomycin fermentation." Tulane University, 1993.

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Important variables such as the cell mass and the product concentrations cannot be measured on-line in bioprocesses because of the limitations in sensor technology. In this dissertation crucial relationships which tie the measured variables to the unmeasured ones thereby overcoming these problems, are developed from a Systems Theory perspective. A successful application is demonstrated with an actinomycete fermentation to produce Spectinomycin A mathematical technique called the External Differential Representation demonstrates how a process can be reconstructed from only a part of the data. T

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26

Brodhagen, Marion L. "Pyoluteorin as a signaling molecule regulating secondary metabolite production and transport genes in Pseudomonas fluorescens Pf-5." Thesis, 2003. http://hdl.handle.net/1957/29900.

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A major factor in the ability of Pseudomonas fluorescens Pf-5 to act as a biological control agent is its production of antibiotics, including pyoluteorin (PLT), 2,4-diacetylphloroglucinol (2,4-DAPG) and pyrrolnitrin (PRN). The data provided in this thesis demonstrate that the presence of any of these antibiotics in the extracellular milieu affects production of that same antibiotic, as well as others, by Pf-5. Amending the growth medium with antibiotics had multiple effects on secondary metabolism in Pf-5. i) PLT positively regulated its own production, ii) 2,4-DAPG positively regulated its o

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27

Wang, Shuyi. "Microbial Impacts of Selected Pharmaceutically Active Compounds Found in Domestic Wastewater Treatment Plants." Diss., 2009. http://hdl.handle.net/10161/1235.

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<p>Large amounts of human pharmaceutical products are consumed worldwide. Many drugs and their metabolites, referred to as pharmaceutically active compounds (PhACs), are not fully metabolized prior to household discharge resulting in their common occurrence in wastewater treatment plants (WWTPs). In most instances, WWTPs present the first treatment opportunity for removing PhACs and preventing significant environmental exposure. Because most municipal WWTPs rely on the microbial component of the activated sludge process, there is a need to estimate the influence of PhACs in wastewater influen

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28

Gielen, G. J. H. P. "The fate and effects of sewage-derived pharmaceuticals in soil : a thesis submitted in partial fulfilment of the requirements for the degree of Doctor of Philosophy at the University of Canterbury /." 2007. http://library.canterbury.ac.nz/etd/adt-NZCU20071009.112712.

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29

Veach, Allison M. "Temporal variation of pharmaceuticals in Indiana streams and degradation potential by sediment microbial communities." 2011. http://liblink.bsu.edu/uhtbin/catkey/1644453.

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This study examined temporal variation of pharmaceutical concentrations in two streams with differing land uses: 1) a suburban stream with combined sewer overflow point sources; and, 2) a rural stream influenced by septic systems and agricultural runoff. Sites were sampled monthly for pharmaceutical concentrations and stream physiochemical parameters. Pharmaceuticals were frequently detected in both the urban and agricultural stream with the highest concentrations measured during winter. Across sites, water column dissolved oxygen concentrations positively correlated with several pharmaceutica

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