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Dissertations / Theses on the topic 'Pharmaceutical Potential'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Cheung, Wai-Han. "Novel steroidal metal complexes with potential pharmaceutical applications." Thesis, Loughborough University, 1992. https://dspace.lboro.ac.uk/2134/27879.

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A study to develop novel lipophilic metal ion complexes based on dihydrocholesterol was undertaken. Steroid ligands functionalised at the 2- and 3- positions were synthesized as possible bidentate ligands for complexation of metal ions. Condensation of 5α-cholestan-3-one with ethyl formate in the presence of base gave 2-hydroxymethylene-5α-cholestan-3-one, and 2- acetyl-5α-cholestan-3-one was obtained by the reaction between 3- trimethylsilyloxy-5α-cholest-2-ene and acetyl chloride. Attempts to synthesize 2,3-dioximino-5α-cholestane from 5α-cholestan-3-one and 2α-hydroxy-5α-cholestan-3-one wer

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2

Umemura, Maki. "Unrealised potential : Japan's post-war pharmaceutical industry, 1945-2005." Thesis, London School of Economics and Political Science (University of London), 2008. http://etheses.lse.ac.uk/2172/.

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Japan's existing pharmaceutical industry was devastated in the Second World War. But the industry recovered quickly, and in 1963, Japan had become the second largest producer of pharmaceuticals after the United States. Unlike its automobile or electronics industries, however, Japan's pharmaceutical industry did not become a global leader. Japan remains a net importer of pharmaceuticals and few Japanese drugs are found outside of Japan. The global pharmaceutical industry is led by firms from the United States, the United Kingdom and Switzerland, rather than those from Japan. This thesis traces

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3

Woolley, Ley Hwee. "Synthesis of potential anthelminthic drugs." Thesis, University of Salford, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.258257.

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4

Hardman, Mark Alan. "Design of potential antiprotozoal daunorubicin derivatives." Thesis, De Montfort University, 1985. http://hdl.handle.net/2086/10737.

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Daunorubicin is an antitumour antibiotic which is highly active against the sleeping sickness parasite Trypanosoma rhodesiense in vitro, but which lacks in vivo activity. The object of this work was to modify daunorubicin so as to promote in vivo activity, and to study the mechanism by which daunorubicin is trypanocidal. A series of daunorubicin analogues, and derivatives in which daunorubicin was linked to a macromolecular carrier (known as daunorubicin conjugates) were prepared, and tested against trypanosome infected mice. Only daunorubicin conjugates in which drug was linked to the carrier

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5

Setiawan, Nico. "UNDERSTANDING THE THERMODYNAMICS AND ORAL ABSORPTION POTENTIAL OF PHARMACEUTICAL AMORPHOUS SOLID DISPERSIONS." UKnowledge, 2018. https://uknowledge.uky.edu/pharmacy_etds/85.

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Supersaturating drug delivery systems, such as amorphous solid dispersions (ASDs), have been used extensively to elevate the apparent solubility and oral bioavailability of poorly water-soluble drugs. However, despite the numerous examples of success in increasing solubility and oral bioavailability using ASDs, physical stability challenges remain as formulators seek to employ high drug loading for cost reduction and improved patient compliance. Therefore, stability in both the solid and solution state must be considered for ASDs to be successful. In the solid state, the drug must remain amorp

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6

Patel, Sanjay S. "Potential short-acting chemodegradable neuromuscular blocking agents." Thesis, University of Bath, 1989. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.234653.

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7

Dentali, Steven John. "Potential antiinfective agents from Eriodictyon angustifolium Nutt. and Salvia apiana Jeps." Diss., The University of Arizona, 1991. http://hdl.handle.net/10150/185511.

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The dichloromethane extracts of twelve US Southwestern herbal remedies were tested against Staphylococcus aureus (9-29 UA), Bacillus subtilis (2-27 UA), Klebsiella pneumoniae (3-9 UA), and Candida brassicae (IFO 1664) in an agar dilution-streak bioassay at 1000 μg/ml. All twelve plants inhibited the growth of B. subtilis. Anemopsis californica, Berberis fendleri, Cacalia decomposita, and Eriodictyon angustifolium inhibited the growth of at least two organisms. Salvia apiana was the only plant in this study to completely inhibit the growth of all four test organisms. After a literature search l

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8

Manson, Andrew John. "The production and potential of antibodies to morphine." Thesis, University of Sunderland, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.303249.

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9

Gordge, Philip Charles. "Potential agonists and inhibitors of protein kinase C." Thesis, University College London (University of London), 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.285430.

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10

Kennedy, Joakim. "Pharmaceutical engineering of microneedle-mediated intradermal nanoparticle delivery device : potential for lymphatic targeting." Thesis, Queen's University Belfast, 2016. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.706993.

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Microneedles (MNs) are minimally invasive drug delivery devices that can be used for transdermal drug delivery (TDD). They have the potential to enhance drug delivery for therapeutic agents which are currently difficult to deliver, costly, or cause a wide range of side effects. The therapeutic agent must normally overcome the highly hydrophobic barrier of the skin’s outermost layer, the stratum corneum (s.c.), in order to be delivered transdermally. MNs have a height of 50 m to 1500 m and overcome the barrier by penetrating the s.c. and creating aqueous pores. They can be fabricated from diffe

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11

Yorke, Matthew. "Photochemistry of amido xanthonate photocages: Potential candidates for polymer-tethered photorelease of drugs." Thesis, University of Ottawa (Canada), 2010. http://hdl.handle.net/10393/28762.

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Recently, photocages capable of releasing biologically relevant molecules have been reported, which utilize the rapid and efficient photodecarboxylation of 2-xanthone acetic acid (XAA) with UVA irradiation. This thesis focuses on the development of functionalized xanthonate photocages to be used for surface-tethering applications. Firstly, the preparation of amine and acetamide functionalized xanthonate (and thioxanthonate) photocage precursors will be described. Investigation into the photochemistry of the prepared derivatives led to the discovery of a solvent composition dependence on the ph

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12

Rees, Jennifer Nicole. "Protein reactivity of 3,4-dihydroxyphenylacetaldehyde, an endogenous, potential neurotoxin relevant to Parkinson's disease." Diss., University of Iowa, 2009. https://ir.uiowa.edu/etd/315.

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Parkinson's disease (PD) is a neurodegenerative disorder characterized by two pathological hallmarks, selective loss of dopaminergic neurons and intraneuronal protein aggregation. The presence of an endogenous neurotoxin has been implicated in the pathogenesis of the disease, to explain the observed neurodegeneration. Dopamine (DA) has been indicated to be an endogenous neurotoxin as DA readily undergoes auto-oxidation to an o-quinone capable of protein modification. However, DA is metabolized by monoamine oxidase to form the intermediate 3,4-dihydroxyphenylacetaldehyde (DOPAL) and several stu

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13

Caston, Antony James. "The potential of fimbriae for bioadhesive drug delivery systems." Thesis, University of Nottingham, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.315131.

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14

Pourgholami, M. H. "Pharmacological studies with potential anticancer agents related to aminoglutethimide." Thesis, Cardiff University, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.377873.

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15

Greene, Ilana. "Kaempferol and Esculetin as Potential Therapeutic Agents in Chronic Renal Allograft Injury." Thesis, Icahn School of Medicine at Mount Sinai, 2015. http://pqdtopen.proquest.com/#viewpdf?dispub=1595299.

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<p> Although chronic allograft damage (CAD) remains a primary barrier to long-term renal allograft survival, limited progress has been made in the discovery of potential therapeutics. In order to identify potential drug therapies, we used two meta-analytical methods to evaluate six post-renal transplant blood and biopsy gene expression data sets (N=275). This resulted in a list of 85 differentially expressed genes that were examined using the Connectivity Map Database (cMAP) in order to identify drugs with the capacity to interrupt the differential gene expression associated with CAD. Among th

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16

Williams, Brett H. "Design and synthesis of 3-[N-(cyclopropylmethyl) amino]-7-(methoxy or hydroxy)-2, 2-dimethyl-1-tetralone analogs as potential opioid receptor antagonists." Scholarly Commons, 2004. https://scholarlycommons.pacific.edu/uop_etds/591.

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A series of 3-aminotetralins were synthesized as potential opioid antagonists. Each proposed target compound was based on a 3-(mono- or dialkylamino )-7 -(hydroxy or methoxy)-2, 2-dimethyl-1-tetralone parent structure. Three synthetic schemes were developed utilizing the common intermediate, ethyl3-benzylamino-2, 2-dimethyl-4-(4- methoxyphenyl)butyrate 3. In Scheme I, compound 3 was modified through a series of six steps to obtain 3-(N-methyl-N-cyclopropanecarboxamido )-7 -methoxy-2, 2-dimethyl- 1-hydroxy-1-phenyltetralin (9). To carry out further synthetic steps on the intermediate 9 required

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17

Kerr, G. "The synthesis of pyrazole C-nucleosides as potential antitumour agents." Thesis, Heriot-Watt University, 1992. http://hdl.handle.net/10399/1454.

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18

McClelland, Alan R. "Event-related brain potential correlates of nicotine and smoking behaviour." Thesis, Queen's University Belfast, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.317560.

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19

Cox, B. "The synthesis of #Beta#-amino ketones as potential antifungal agents." Thesis, University of Manchester, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.375078.

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20

Di, Pretoro Anna M. A. "The synthesis of morphine-6-glucuronide analogues as potential analgesics." Thesis, Loughborough University, 1996. https://dspace.lboro.ac.uk/2134/32407.

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It is known that morphine-6-glucuronide is more potent than morphine, but it is difficult and expensive to produce. Our aim was to synthesise an analogue(s) of morphine-6-glucuronide which would have similar or enhanced properties, but that could be obtained via a simple synthetic route. It is hoped that such a compound could be used to treat terminally ill cancer patients. Due to the enhanced potency a smaller dose of the drug would be required to effect the same analgesic effect as morphine, and this may help to reduce the effect of morphine tolerance.

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21

Pendleton, Morgan, Stacy D. Brown, Christan M. Thomas, and Brian Odle. "Potential Toxicity of Caffeine when Used as a Dietary Supplement for Weight Loss." Digital Commons @ East Tennessee State University, 2013. https://dc.etsu.edu/etsu-works/5321.

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Background: Caffeine is added to dietary supplements to increase energy and suppress appetite. Many people take dietary supplements for weight loss. Patients may be unaware that supplements can contain caffeine, even if caffeine is not listed as an ingredient. Commonly used herbal dietary supplement ingredients, such as guarana, are natural sources of caffeine. Objective: To describe a case of possible caffeine-induced seizure in a patient taking an over-the-counter weight loss supplement. Case Report: A previously healthy 38-year-old female experienced blurring of vision and a new onset grand

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22

Sepcic, Kelly Hall. "Sythesis of mazindol derivatives as potential irreversible antagonists of cocaine and other stimulants." Thesis, Georgia Institute of Technology, 1992. http://hdl.handle.net/1853/26819.

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23

Winker, Martina. "Pharmaceutical residues in urine and potential risks related to usage as fertiliser in agriculture." Hamburg [TuTech Innovation], 2009. http://d-nb.info/994334494/34.

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24

Morel, Chantal. "Pharmaceutical prices 1999-2008 : an exploration into global variation, comparative measures, and potential determinants." Thesis, London School of Economics and Political Science (University of London), 2015. http://etheses.lse.ac.uk/3405/.

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Despite globalization, major differences in access and affordability of pharmaceuticals remain across the countries of the world. This dissertation aims at quantifying the differences in the price of pharmaceuticals amongst countries, identifying the factors responsible for these differences, and examining the policy consequences. Paper 1 compares prices in a large set of middle-income countries to some high- and lowincome countries. It finds that prices of pharmaceuticals are inconsistently related to income, with many middle-income countries paying more than some high-income countries and so

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25

Broadbent, Andrew. "The potential application of supercritical fluids to the production of coatings for pharmaceutical products." Thesis, University of Bath, 1999. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.323594.

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26

Wedge, Stephen Robert. "Mechanism of action of polymer-anthracyclines : potential to overcome multidrug resistance." Thesis, Keele University, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.293794.

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27

Coe, Diane Mary. "Synthesis of carbocyclic nucleoside and nucleotide analogues as potential antiviral agents." Thesis, University of Exeter, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294036.

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28

Davies, Jayne Louise. "Electrorheological fluids as smart medicines with potential in controllable drug delivery." Thesis, University of Bath, 1999. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301535.

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29

Cittern, P. "On the synthesis and characterisation of some novel potential narcotic analgesics." Thesis, University of Bath, 1989. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.329285.

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30

Cusack, Michael. "Development of a Focused Library of C2 and C5 Modified 4-Chromanone Derivatives as Potential Antimicrobials." Thesis, Southern Illinois University at Edwardsville, 2018. http://pqdtopen.proquest.com/#viewpdf?dispub=10808318.

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31

Hayes, Michael Patrick. "Chemical inhibitors of protein-protein interactions involved in G protein-mediated signaling events as potential therapeutics." Diss., University of Iowa, 2017. https://ir.uiowa.edu/etd/5945.

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G protein-coupled receptors (GPCRs) play a central role in numerous biological processes, from olfaction to vision to neurotransmission and more, leading to their classification as important drug targets. Signaling through GPCRs is carried out by a number of intracellular effector proteins, such as the α subunits of heterotrimeric G proteins and Adenylyl Cyclases (AC). In this work, inhibition of protein-protein interactions to reduce GPCR-mediated cAMP formation is explored to identify compounds with potential therapeutic value. Regulators of G Protein Signaling (RGS) inhibit Gαi/o signaling,

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32

Furbacher, Todd Raymond. "Bioassay-guided isolation of potential antineoplastic natural products from Southwestern plants." Diss., The University of Arizona, 2001. http://hdl.handle.net/10150/279927.

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This dissertation details the investigation of numerous plants for potential antineoplastic compounds. 144 plants (391 extracts) were prescreened with an assortment of assays. The pre-screens included an Agrobacterium tumefaciens/potato disk gall tumor inhibition assay, a Saccharomyces cerevisiae mutant topoisomerase assay, and an Escherichia coli plasmid scission assay. Bioassay-guided fractionation was conducted on three plants, Phoradendron juniperinum, Psorothamnus thompsoniae , and Acourtia thurberi, using a different assay for each. Phoradendron juniperinum (Viscaceae) was screened with

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33

Maahs, Michael Keith. "Medical Academia Conflict of Interest Policy and Potential Impact on Research Funding." ScholarWorks, 2015. http://scholarworks.waldenu.edu/dissertations/1317.

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Medical Academia Conflict of Interest Policy and Potential Impact on Research Funding by Michael K. Maahs MPA, Troy University, 1993 BA, Ripon College, 1990 Dissertation Submitted in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy Public Policy and Administration Walden University July 2015 The partnership between medical academia and the pharmaceutical industry has been scrutinized for issues associated with research bias. As a result of this scrutiny, the Institute of Medicine (IOM) issued policy recommendations in 2009 directing academia to adopt comprehensive

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34

Alley, Genevieve. "α2-ADRENOCEPTOR AND 5-HT3 SEROTONIN RECEPTOR LIGANDS AS POTENTIAL ANALGESIC ADJUVANTS". VCU Scholars Compass, 2012. http://scholarscompass.vcu.edu/etd/2867.

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There continues to be a need for more effective analgesics. The α2-adrenoceptor (AR) agonist clonidine is an analgesic whose use is severely limited by undesirable side effects. meta-Chlorophenylguanidine (MD-354), an agent developed in our laboratory, selectively potentiates the antinociceptive effects of clonidine in a biphasic manner. Mechanistic studies suggest that both 5-HT3 receptor and α2-AR mechanisms are involved. To further evaluate mechanisms underlying the analgesia-potentiating effect of clonidine by MD-354, pharmacological studies using more established 5-HT3 receptor agonists

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35

Pongsaanutin, Tarinee. "Fabrication and characterisation of calcium phosphate and liposome composites for potential drug delivery devices." Thesis, University of Oxford, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249572.

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36

Yaseen, Mohammed. "Gap junctional intercellular communication : methodologies for measurement and application to potential inhibitors of communication." Thesis, University College London (University of London), 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.261718.

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37

Peron, Jean-Marie. "Quantitative structure activity relationship analysis of anti-oxidants with central nervous system therapeutic potential." Thesis, King's College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271327.

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38

Pang, Yu. "Human Anti-Histone 3.3 Antibodies as Potential Biotherapeutics for Chronic Obstructive Pulmonary Disease (COPD)." Master's thesis, Temple University Libraries, 2016. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/378762.

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Pharmaceutical Sciences<br>M.S.<br>Chronic Obstructive Pulmonary Disease (COPD), which is characterized by limitation of pulmonary air flow, is now the third major cause of death worldwide. Barrero et al. have reported that the elevation of extracellular hyperacetylated histone H3.3 in the lungs of COPD patients is associated with cytotoxicity and disease progression. They found that extracellular hyperacetylated H3.3 was cytotoxic to lung structural cells and resistant to proteasomal degradation, and that mouse antibodies to either the C- or N- termini of H3.3 could partially reverse H3.3 tox

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39

Barnes, A. R. "Detection and assay of hydroxyl radicals by chemical means of potential application to pharmaceutical stability studies." Thesis, De Montfort University, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.373417.

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40

Essel, Augustine. "Synthesis of a Water Soluble Resveratrol Derivative as a Potential Anti-Cancer Drug." Digital Commons @ East Tennessee State University, 2010. https://dc.etsu.edu/etd/1738.

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Research on development of water soluble anti-cancer drugs is one of the great challenges of modern medicinal chemistry. Resveratrol (Res) is one of the many phytoalexins producing stilbenoids present in several medicinal plants, grape skin, peanuts, and red wine. It has been found to exhibit anti-cancer, anti-inflammatory, and anti-oxidant properties. Water solubility and bioavailability are some of the setbacks of this interesting compound. In view of this, effort has been made to synthesize amino acid derivative of resveratrol to improve its bioavailability and solubility in water. Methyl 4

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41

Winker, Martina [Verfasser]. "Pharmaceutical residues in urine and potential risks related to usage as fertiliser in agriculture / Martina Winker." Hamburg : [TuTech Innovation], 2009. http://d-nb.info/994334494/34.

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42

Bossaer, John B. "Addressing Potential Interactions Between Antineoplastics and Dietary Supplements." Digital Commons @ East Tennessee State University, 2015. https://doi.org/10.2146/ajhp140295.

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43

Leathley, Michael John. "An assessment of the dependence potential novel anxiolytic drugs and their effects on benzodiazepine withdrawal." Thesis, University of Liverpool, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.240267.

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44

Rawden, Helen Clare. "An investigation of potential chemotherapeutic drug combinations with albendazole for the treatment of Echinococcus infection." Thesis, University of Liverpool, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366355.

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45

Meredith, Emma Louise. "The chemistry of thiocarbamides in relation to their potential use as false precursors of melanin." Thesis, University of Strathclyde, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366841.

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46

Robson, Rachel L. "Regulation of chemokines and IL-6 production in human mesangial cells : potential role in glomerulonephritis." Thesis, University of Bath, 1996. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.320436.

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47

McQuay, H. J. "Morphine : evidence of extra-hepatic metabolism in man and the potential of spinal routes of administration." Thesis, University of Oxford, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.355782.

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48

Maianti, Juan Pablo. "Therapeutic potential and physiological roles of Insulin-Degrading Enzyme illuminated by a DNA-templated macrocyclic inhibitor." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:17467523.

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Insulin-Degrading Enzyme (IDE) is a zinc-metalloprotease responsible for the clearance of insulin in peripheral tissues. Despite decades of speculation that inhibiting endogenous insulin degradation might treat Type-2 Diabetes, the functional relationship between IDE and glucose homeostasis remains unclear. IDE inhibitors that are active in vivo are therefore needed to elucidate IDE’s physiological roles and to determine its potential to serve as a target for the treatment of diabetes. In this thesis I describe the development of the first highly specific IDE in vivo probe, identified from

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49

Jaffar, M. "On the synthesis and stereochemistry of novel phenindamine and histryl analogues as potential H₁-histamine antagonists." Thesis, University of Bath, 1993. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.332338.

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50

Slaughter, Kimari. "Synthesis and Development of Potential CB1 Receptor Neutral Antagonists." ScholarWorks@UNO, 2012. http://scholarworks.uno.edu/td/1483.

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Cannabis and its derivatives have been used for both medicinal and recreational purposes. The study of this plant led to the discovery of over 60 cannabinoids, found exclusively in cannabis, that contribute to the behavioral effects of cannabis use, the most common is delta-9-tetrahydrocannabinol. Cannabinoid receptors function to increase activity in the mesolimbic dopamine reward system. Dopamine is a neurotransmitter that plays a major role in addition and its regulation plays a crucial role in mental and physical well-being. There is evidence that CB1 receptors are important to the reinfor

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