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Dissertations / Theses on the topic 'Pharmaceutical safety of the state'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

McKellar, Scott Campbell. "Crystal engineering approaches to solid-state pharmaceutical systems." Thesis, University of Strathclyde, 2012. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=18024.

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Control of a solid drug's physical form is an important stage of drug development, in order to best optimise the physicochemical properties of the drug. It is also important for intellectual property and regulatory considerations. Commonly, optimisation of a solid drug form moves beyond controlling the solid-state and actively manipulating it, via salt formation, co-crystal synthesis or inclusion complexation, for example. Presented in this work are three distinct approaches to the control and development of solid-state form of organic molecules and pharmaceuticals. The first of these approach

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2

Eren, Ipek. "The transnationalisation of the Turkish pharmaceutical industry." Thesis, University of Sussex, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249110.

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3

Pal, Arindom. "Development of a new class of ligand-targeted chemotherapeutics with enhanced safety and efficacy profile." Scholarly Commons, 2019. https://scholarlycommons.pacific.edu/uop_etds/3642.

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The hydrophobicity of many chemotherapeutic agents usually results in their nonselective passive distribution into healthy cells and organs causing collateral toxicity. Ligand-targeted drugs (LTDs) are a promising class of targeted anticancer agents. The hydrophilicity of the targeting ligands in LTDs limits its nonselective passive tissue distribution and toxicity to healthy cells. In addition, the small size of LTDs allows for better tumor penetration, especially in the case of solid tumors. However, the short circulation half-life of LTDs, due to their hydrophilicity and small size, rem

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4

Gustafsson, Christina. "Solid state characterisation and compaction behaviour of pharmaceutical materials." Doctoral thesis, Uppsala University, Department of Pharmacy, 2000. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-509.

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<p>In this thesis, factors important in tableting operations and for tablet properties have been studied and characterised by different spectroscopic techniques as well as by some more conventionally used particle characterisation techniques. The spectroscopic techniques solid-state NMR, FT-IR and NIR spectroscopy, proved to be valuable tools in the estimation of particle and tablet properties, offering both specificity and sensitivity in the measurements. Because of the large amount of information obtained in a spectrum, multivariate data analysis was in some cases used in the processing of t

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5

Hunt, John Anthony. "The development of pharmaceutical services in the British welfare state." Thesis, University of Portsmouth, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266923.

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6

Hellrup, Joel. "Pharmaceutical Nanocomposites : Structure–Mobility–Functionality Relationships in the Amorphous State." Doctoral thesis, Uppsala universitet, Institutionen för farmaci, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-300159.

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Amorphous materials are found in pharmaceutical formulations both as excipients and active ingredients. Indeed, these formulations are becoming an essential strategy for incorporating drugs into well-performing solid dosage forms. However, there is an unmet need of better understanding of the microstructure and component interactions in amorphous formulations to be able to design materials with improved functionalities. The aim of this thesis is to give deepened knowledge about structure-mobility-functionality relationships in amorphous for-mulations by studying composites produced from sugars

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7

Brisson, Julie. "Civil aviation safety in Russia: the state of compliance." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=104674.

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Considering that civil aviation safety is one of the most important elements in all aviation-related activities, this thesis presents the state of compliance of aviation safety in the Russian Federation. In the former Soviet Union, the authorities made sure that the rest of the world knew that its territory was impenetrable. In the 1980s, their attack on the civilian flight KE 007 of the Korean Airlines, which lead to the crash of the aircraft and the death of innocent civilian passengers, demonstrated that when it came to guarding their territory, they showed little concern for the lives of i

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8

Li, Stephen Yiu Kwong. "Port state control and its implication on ship safety." Thesis, University of Plymouth, 2002. http://hdl.handle.net/10026.1/2154.

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Over the past twenty years a growth in sub-standard shipping has been observed. The thesis identifies the causes of this growth. It then identifies Port State Control (PSC) as a measure evolved by some states, with the purpose of removing sub-standard shipping from their waters, and thereby improving maritime safety and the protection of the environment. The purposeo f this programmeo f researchi s to assessth e effectivenesso f PSC in achieving its purpose. An eclectic research methodology has been adopted which first considers, in depth, the global and regional context in which PSC functions

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9

Guilbaud, Jean-Baptiste A. M. "Solid-state NMR studies of polymer-drug interactions in pharmaceutical formulations." Thesis, University of Liverpool, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.486441.

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The development of pharmaceuticals (both drugs and their formulations) requires the characterisation of the materials in their dispensed form. Solid-state NMR is particularly appropriate for studies of such system as it does not require any pre-treatment which might affect the material properties. This methodology also provides a molecular level understanding of intra- and intermolecular bonding as well as the dynamics in pharmaceutical formulations crucial for directing their physical properties, stability, bioavailability and release kinetics of a drug in a composite. Solid-state NMR spectro

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10

Campbell, Susan Christina. "Pharmaceutical polymorphism : an investigation using solid-state nuclear magnetic resonance spectroscopy." Thesis, Durham University, 1998. http://etheses.dur.ac.uk/5021/.

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The study of two pharmaceutically active systems that each display polymorphism has provided a platform upon which to develop and apply solid-state NMR techniques in order to increase the understanding of the solid-state structure of small organic molecules. The multidisciplinary approach adopted has highlighted the advantages of solid-state NMR as a non-invasive probe of molecular conformation and crystallographic packing.Carbon-13 CP/MAS spectra of the two polymorphs of BRL55834 - a fluorinated benzopyran derivative - immediately suggest the presence of one and three molecules in the asymmet

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11

Beyer, Andreas [Verfasser], and Claudia [Akademischer Betreuer] Leopold. "Solid state transformations during pharmaceutical processes / Andreas Beyer ; Betreuer: Claudia Leopold." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2020. http://d-nb.info/120967601X/34.

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12

Al-Zayani, Salman Rashid. "Road safety budget optimisation model for the state of Bahrain." Thesis, University of Leicester, 1992. http://hdl.handle.net/2381/31803.

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The aim of this study is to develop a procedure that can be used for the optimal allocation of funds available for road safety remedial measures in the State of Bahrain. The study reviews the nature of the road accidents problem in Bahrain in sufficient detail to highlight the relative magnitude ·and seriousness of the problem. Factors comprising the total (comprehensive) cost of road safety remedial measures with special application to Bahrain (including the capital and maintenance costs of the remedial measures and accident component of road user costs) are identified and analysed. A methodo

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13

Lingerfelt, Wes, and Dan Dawson. "A Small State-of-the Art Range Safety Telemetry System." International Foundation for Telemetering, 1993. http://hdl.handle.net/10150/611839.

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International Telemetering Conference Proceedings / October 25-28, 1993 / Riviera Hotel and Convention Center, Las Vegas, Nevada<br>The US Air Force is required to protect the lives of individuals and property in areas potentially hazardous as a result of launch vehicle failures occurring from Vandenberg AFB, California. This paper describes the application of modern telemetry processing equipment to the Range Safety function.

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14

Wright, Elaine Ann. "Solid state crystallisation of oligosaccharide ester derivatives." Thesis, University of Strathclyde, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249016.

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15

Echeverri, Ana Lucia Hincapie. "Relationship between Perceived Healthcare Quality and Patient Safety." Diss., The University of Arizona, 2013. http://hdl.handle.net/10150/283602.

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The objectives of this study were to examine the association between patient perceived healthcare quality and self-reported medical, medication, and laboratory errors using cross-sectional and cross-national questionnaire data from eleven countries. In this research, quality of care was measured by a multi-faceted construct, which adopted the patient's perspectives. Five separated quality of care scales were assessed: Access to Care, Continuity of care, Communication of Care, Care Coordination, and Provider's Respect for Patients' Preferences. The findings from this investigation support a nu

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16

Lofgren, Hans. "Globalisation of the pharmaceutical industry and the Australian state : the transformation of a policy network /." Connect to thesis, 1997. http://eprints.unimelb.edu.au/archive/00000300.

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17

Mauldin, Jo A. Seaman John Weldon. "Bayesian approaches to problems in drug safety and adaptive clinical trial designs." Waco, Tex. : Baylor University, 2008. http://hdl.handle.net/2104/5177.

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18

White, Becky A. "The perceptions and beliefs of nurses using Knowledge Based Medication Administration (KBMA) bar code scanning processes in regards to patient safety." Thesis, Blessing-Rieman College of Nursing, 2015. http://pqdtopen.proquest.com/#viewpdf?dispub=1598248.

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<p>Accurate and safe medication administration is an important aspect in the everyday care of the hospitalized patient. Patients put their trust and safety into the hands of those providing care and expect that care is provided in a safe and efficient manner. Nurses strive to provide high quality error free, patient care. With adult patients, medication administration accounts for 26% to 32% of hospital medication errors (Koppel, Wetterneck, Telles, & Karsh, 2008). Only 2% of administration errors are corrected before reaching the patient (Dwibedi, et al., 2011). Literature supports that k

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19

Vella-Bonnici, Joseph. "Superior economic performance in a small state : the pharmaceutical industry in Malta." Thesis, Loughborough University, 2015. https://dspace.lboro.ac.uk/2134/22176.

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Various academic disciplines have attempted to explain the factors underpinning superior economic performance. Generally they neglect the realities of small states. The literature fails to clearly define a small state . Mainstream theories associate smallness with sub-optimality . Small states studies tend to be conditioned by a vulnerability complex. Yet, a good number of small states have an economic track record which is the envy of much larger states. This thesis adopts an interdisciplinary approach to investigate the theoretical explanations of superior economic performance, at both the s

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20

Majumder, Mridul. "Exploring the role of the amorphous state in pharmaceutical co-crystal production." Thesis, University of Reading, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610963.

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Pharmaceutical co-crystals are multicomponent crystalline materials with defined stoichiometry, often stabilized by hydrogen bonding. Numerous studies into co-crystals have been carried out over the last decade or so with the primary aim being to improve the bioavailability of poorly soluble drugs by this crystal engineering technique. However, knowledge gaps remain in understanding the mechanisms by which co-crystals are formed in the solid-state, screening strategies and scale up processes leading to formulation development that are key to success using this approach. The research presented

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21

Greenwood, J. R. "The market and the state : The pharmaceutical representative and general medical practice." Thesis, University of Nottingham, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.380978.

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22

Singh, Mahender Pal 1965. "The pharmaceutical supply chain : a diagnosis of the state-of-the-art." Thesis, Massachusetts Institute of Technology, 2005. http://hdl.handle.net/1721.1/33354.

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Thesis (M. Eng. in Logistics)--Massachusetts Institute of Technology, Engineering Systems Division, 2005.<br>Includes bibliographical references (leaves 148-150).<br>This study explores the current supply chain trends in the pharmaceutical industry. The main objective of the study is to characterize the pharmaceutical industry and identify excellent supply chain practices. Indeed, the pharmaceutical industry is not renowned for its supply chain management capabilities, unlike many other highly publicized industries that have profitably exploited their supply chains. It is, thus, an interesting

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23

Tatton, Andrew S. "Development of solid-state NMR techniques for the characterisation of pharmaceutical compounds." Thesis, University of Warwick, 2012. http://wrap.warwick.ac.uk/51660/.

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Structural characterisation in the solid state is an important step in understanding the physical and chemical properties of a material. In pharmaceuticals, an active pharmaceutical ingredient (API) may be medicinally favourable, but have undesirable physical properties, such as poor solubility, that potentially limit further development. Solid delivery forms, such as pharmaceutical salts, cocrystals and solid amorphous dispersions, potentially offer improvements in physical properties, whilst maintaining favourable medicinal characteristics. Solid-state NMR is an extremely sensitive probe of

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24

Beyer, Andreas [Verfasser], and Claudia S. [Akademischer Betreuer] Leopold. "Solid state transformations during pharmaceutical processes / Andreas Beyer ; Betreuer: Claudia S. Leopold." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2019. http://d-nb.info/1194165087/34.

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25

Tinmanee, Radaduen. "The role of pharmaceutical excipients in the solid-state degradation of Gabapentin." Diss., University of Iowa, 2015. https://ir.uiowa.edu/etd/1919.

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Drug instability in solid dosage forms includes chemical or physical processes involving covalent or polymorphic transformations wherein different polymorphs possess crystal structure differences. Gabapentin chemically degrades by intramolecular cyclization to gabapentin-lactam (lactam) in the solid-state. Additionally, gabapentin undergoes polymorphic solid-state transformations. A kinetic model was developed to describe the environmental and excipient effects on chemical and physical instability associated with milling induced stress and subsequent storage under controlled temperature and hu

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26

Bah-Traore, Ndjamawe [Verfasser]. "Quality assurance and safety issue of pharmaceutical products marketed in developing countries / Ndjamawe Bah-Traore." Bonn : Universitäts- und Landesbibliothek Bonn, 2012. http://d-nb.info/1044082860/34.

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27

Alenazi, Mounifah. "Toward Improved Traceability of Safety Requirements and State-Based Design Models." University of Cincinnati / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1623168093414723.

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28

Khawam, Ammar. "Application of solid-state kinetics to desolvation reactions." Diss., University of Iowa, 2007. http://ir.uiowa.edu/etd/170.

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29

Ackerman, Kathryn R. "A Critical Review of the Procedure to Develop the State Highway Safety Plan." University of Akron / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=akron1613961199444157.

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30

Sawangchan, Phawanan. "The effect of aggregation state on the degradation kinetics of Amphotericin B in aqueous solution." Diss., University of Iowa, 2017. https://ir.uiowa.edu/etd/5992.

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Amphotericin B (AmB) is an amphiphile antifungal agent composed of lipophilic and hydrophilic structures and is known to aggregate in aqueous solution. The effect of substrate aggregation on the degradation kinetics of aqueous AmB was studied. Aggregation state of AmB (0.0108 mM) in 10.0%v/v methanol aqueous solutions were pH dependent. The dissociation equilibrium constant (Kd) values suggested that monomeric form was predominant in acidic and alkaline condition and aggregated form appeared predominantly in neutral condition. At methanol concentration above 35.0%v/v, 0.0108 mM AmB in reaction

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31

Oburn, Shalisa M. "Applications in supramolecular chemistry and solid-state reactivity: template-mediated solid-state reactions, dynamic covalent chemistry, mechanochemistry, and pharmaceutical co-crystals." Diss., University of Iowa, 2019. https://ir.uiowa.edu/etd/7004.

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Supramolecular chemistry and crystal engineering seek to control molecular packing in the solid state to influence the physical and chemical properties of crystalline solid materials. A goal of supramolecular chemistry that seeks to control molecular packing in the solid state focuses on exploiting non-covalent interactions to assemble molecules into desirable arrangements. Strategies implemented to control molecular packing rely on strong, directional interactions such as hydrogen bonding, halogen bonding, and metal coordination to direct localized arrangement of molecules in solids. In this

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32

Lassé, Moritz. "Does the Protein Aggregation State Affect the Digestibility and Safety of Foods?" Thesis, University of Canterbury. School of Biological Sciences, 2013. http://hdl.handle.net/10092/8403.

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This thesis explores the complex relationship between food protein structure and digestibility. Food proteins are important nutrients that play a central role in controlling the textural properties of many foods. Processing of food proteins may alter the protein aggregate structure and digestibility. The degree of protein aggregation during food processing depends on the denaturing conditions and the presence of other food components. Sugars and lipids may contribute to protein glycation and protein cross-linking via the Maillard reaction. Furthermore, amino acid residues of food proteins may

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33

Mahmud, Nidhal. "Dynamic model-based safety analysis : from state machines to temporal fault trees." Thesis, University of Hull, 2012. http://hydra.hull.ac.uk/resources/hull:6757.

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Finite state transition models such as State Machines (SMs) have become a prevalent paradigm for the description of dynamic systems. Such models are well-suited to modelling the behaviour of complex systems, including in conditions of failure, and where the order in which failures and fault events occur can affect the overall outcome (e.g. total failure of the system). For the safety assessment though, the SM failure behavioural models need to be converted to analysis models like Generalised Stochastic Petri Nets (GSPNs), Markov Chains (MCs) or Fault Trees (FTs). This is particularly important

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34

Hassan, Aymane. "Handling river floating debris for dam safety – the state of the practice." Thesis, KTH, Betongbyggnad, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-289387.

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This study reviews the current knowledge and state of the practice for handling floating debris for dam safety. This report is a guidance to improve the understanding of risks of floating debris for dam safety and of countermeasures for risk reduction. The strengths and limitations of current approaches related to dam vulnerability assessment and handling strategies are discussed and recommendations are provided. Several countries experienced issues with floating debris which often led to severe damages to dam spillways. High and extreme flood events could be responsible for similar incidents

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35

Greene, K. H. "The sharing of safety information between hospitals in the state of Victoria." Thesis, Federation University Australia, 1989. http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/165032.

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"This study uses two examples of occupational health and safety problems encountered in nine major hospitals to illustrate that hospitals fail to identify, evaluate and share information adequately. The two safety examples used are 1. Needle-stick incidents 2. The potential for injuries associated with floor cleaning methods."<br>Masters Degree in Applied Science, Occupational Health and Safety

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36

Dinge, Aditya. "EUTECTIC MIXTURES OF DRUGS WITH POOR AQUEOUS SOLUBILITY - SOLID STATE CHARACTERIZATION AND DISSOLUTION STUDIES." Diss., Temple University Libraries, 2012. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/196371.

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Pharmaceutical Sciences<br>Ph.D.<br>It is a well reported fact that large number of drugs coming of the drug discovery pipeline show poor aqueous solubility. Eutectic mixture formation of poorly soluble drugs with hydrophilic carriers has been used to enhance the dissolution rate of such poorly soluble drugs. Eutectic mixtures are solid dispersions where the drug and the carrier are both in crystalline form. The eutectic mixture has a lower melting point than either component. Eutectic mixtures are thermodynamically stable systems. The feasibility of developing a dosage form from an eutectic m

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37

Worthington, Matthew Stanley. "Nifedipine-cyclodextrin binary systems : solid-state photostability and dissolution behaviour." Thesis, Rhodes University, 1998. http://hdl.handle.net/10962/d1007233.

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Nifedipine is a photolabile calcium channel antagonist which undergoes rapid photodegradation in solution and in solid-state with an accompanying loss of pharmacological potency and clinical efficacy. Nifedipine photostabilization which has received considerable attention has principally been achieved by physical obscuration and through the use of colourants or ultraviolet light absorbers incorporated into liquid preparations, translucent packaging materials, gelatin capsules and/or their fillings and tablet coatings or cores. This study was initiated by a South African pharmaceutical manufact

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38

Rhodes, Stephanie Marie. "The Environmental Design Barrier:Gendered Perceptions of Safety on The Ohio State University Campus." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1555323315548223.

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39

Katayama, Derrick S. "Towards a mechanistic understanding of pharmaceutical protein stabilization in solution and the solid state /." Connect to full text via ProQuest. Limited to UCD Anschutz Medical Campus, 2006.

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Thesis (Ph.D. in Pharmaceutical Sciences) -- University of Colorado at Denver and Health Sciences Center, 2006.<br>Typescript. Includes bibliographical references (leaves 159-173). Free to UCDHSC affiliates. Online version available via ProQuest Digital Dissertations;

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40

Robbins, Andrew James. "Sensitivity and resolution in 19F and 15N solid-state NMR : applications to pharmaceutical systems." Thesis, Durham University, 2009. http://etheses.dur.ac.uk/94/.

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This thesis describes a study into the improvement of solid-state NMR methods for the detection and characterisation of pharmaceutical compound. Chapter 1 reviews the literature that are relevant to the techniques discussed within this thesis Chapter 2 outlines the key experimental techniques employed within this work. Chapter 3 investigates the usefulness of indirect detection as a method to detect and possibly quantify the ratio of 15N present for multiple 15N containing systems. The work highlights how for CP performed at fast MAS, there is a much greater sensitivity to the RF inhomogeneity

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41

Yam, Noymi. "Molecular interactions of biologically active derivatives of sulfamide with pharmaceutical polymers in solid state." Scholarly Commons, 2009. https://scholarlycommons.pacific.edu/uop_etds/2398.

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Molecular interactions of small molecules with polymers in solid state have numerous applications in pharmaceutical research. This dissertation examines the mechanism of the solid state interactions of the biologically active sulfamide derivatives with polyethylene glycol (PEG) and structurally related polymers. It is shown that in addition to the formation of the eutectic systems, PEG and related polymers cause polymorphic transitions of sulfamide derivatives. A new polymorphic form of a model sulfamate, topiramate, has been discovered and characterized using multiple analytical techniques. T

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42

Hagemeier, Nicholas E. "Naloxone: The State of Co-Prescribing and Co-Dispensing." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/etsu-works/5425.

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43

Hamrén, Bengt. "Safety and Efficacy Modelling in Anti-Diabetic Drug Development." Doctoral thesis, Uppsala University, Division of Pharmacokinetics and Drug Therapy, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8648.

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<p>A central aim in drug development is to ensure that the new drug is efficacious and safe in the intended patient population.</p><p>Mathematical models describing the pharmacokinetic-pharmacodynamic (PK-PD) properties of a drug are valuable to increase the knowledge about drug effects and disease and can be used to inform decisions. The aim of this thesis was to develop mechanism-based PK-PD-disease models for important safety and efficacy biomarkers used in anti-diabetic drug development. </p><p>Population PK, PK-PD and disease models were developed, based on data from clinical studies in s

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44

LeDew, Christopher. "SAFETY EFFECTS OF TRAFFIC SIGNAL INSTALLATIONS ON STATE ROAD INTERSECTIONS IN NORTHEAST FLORIDA." Master's thesis, University of Central Florida, 2006. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/3446.

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The purpose of this thesis is to explore how the installations of traffic signals affect crash experience at intersections, to identify those factors which help predict crashes after a signal is installed, and to develop a crash prediction model. It is the intent of this thesis to supplement the Manual on Uniform Traffic Control Devices Signal Warrant procedure and aid the traffic engineer in the signal installation decision making process. Crash data, as well as operational and geometric factors were examined for 32 state road intersections in the northeast Florida area before and after signa

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45

Young, Hunter T. "A Safety Analysis of Fatigue and Drowsy Driving in the State of Utah." BYU ScholarsArchive, 2007. https://scholarsarchive.byu.edu/etd/1161.

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Fatigue and drowsy driving in the state of Utah has been a causal factor in thousands of crashes over the years and poses a serious threat to public safety. Consequently, the purpose of this research was to evaluate the impact of drowsy driving in the state, to identify locations where fatigue and drowsy driving may be contributing factors to current crashes, and to identify methods to help mitigate these crashes. A 3-year drowsy driving crash rate spanning the years 2002 – 2004 was used to determine which segments of Utah highway are most prone to drowsy driving crashes. Drowsy driving corrid

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46

Mortimer, Anthony D. "Priorities for School Safety: The Alignment between Federal and State School Safety Legislation and Safety Needs as Perceived by Education Stakeholders in Florida Private Schools for Exceptional Students." UNF Digital Commons, 2018. https://digitalcommons.unf.edu/etd/807.

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This study investigates the apparent threat assessment priorities of potential risks to safety in the school environment in the United States and whether stakeholders in Florida private schools that serve exceptional students agree with the priority given to specific identified potential threats. Faculty and staff, high school students, and the students’ parents and guardians at four Florida private schools for exceptional students rated their perceptions of the severity and likelihood of occurrence of nine potential threats identified in a review of federal and Florida state school safety law

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47

Parker, A. W. "Excited state studies of pyrimidine bases and radiosensitizing drugs by laser flash photolysis." Thesis, University of Warwick, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.377105.

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48

HAUSMAN-MANNING, DEBRA SUE. "APPLICATION OF PROCESS ANALYTICAL TECHNOLOGY TO PHARMACEUTICAL PROCESSES." University of Cincinnati / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1108838053.

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49

Noonan, Terence James. "Preformulation solid-state supramolecular beneficiation of selected active pharmaceutical ingredients and a novel drug candidate." Doctoral thesis, University of Cape Town, 2018. http://hdl.handle.net/11427/29279.

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The aim from the outset of the project on which this thesis is based was to make use of contemporary methods in the field of supramolecular chemistry to improve the suboptimal physicochemical properties of selected compounds for use in the formulation of pharmaceutical products. The compounds selected were: Clevudine, an established drug that is currently in use for the treatment of chronic hepatitis B infections, 6-(3- (Methylsulfonyl)phenyl)-3-(4-(methylsulfonyl)phenyl)-imidazo[1,2-b]pyridazine (MMV652103), a novel antimalarial drug candidate that displayed good in vitro potency against mult

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50

Fitzgerald, Sharon. "The regulation of medicinal products : an analysis of the impact on pharmaceutical innovation, consumer safety and legal redress." Thesis, University of Strathclyde, 1998. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=23780.

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The adverse consequences of the use of thalidomide in the 1950s and 1960s by pregnant women, instigated law reform in the United Kingdom and Europe, in relation to product liability and the regulation of medicinal products. In this Thesis, it is suggested that a legislative framework should balance three elements: consumer safety, legal redress and pharmaceutical innovation. Chapter Three examines the development of the legislative framework in the United Kingdom following thalidomide and considers the impact of the Medicines Act 1968, the Medicines for Human Use (Marketing Authorisations Etc.

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