Relevant bibliographies by topics / Pharmacokinetics

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Pharmacokinetics'

Author: Grafiati
Published: 4 June 2021
Last updated: 25 July 2025

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Journal articles on the topic "Pharmacokinetics"

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Iorio, Alfonso. "Using pharmacokinetics to individualize hemophilia therapy." Hematology 2017, no. 1 (2017): 595–604. http://dx.doi.org/10.1182/asheducation-2017.1.595.

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Abstract Prevention and treatment of bleeding in hemophilia requires that plasma clotting factor activity of the replaced factor exceeds a defined target level. Most clinical decisions in hemophilia are based on implicit or explicit application of pharmacokinetic measures. The large interindividual variability in pharmacokinetics of factor concentrates suggests that relying on the average pharmacokinetic characteristics of factor concentrates would not allow optimizing the treatment of individual patients; for example, adjusting the frequency of infusions and targeting a specific clotting fact
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Ashwaq, Abdulhamid Alahmadi* Maram Meshal Alsulami Khulud Khalid Alnami Mayssa Ahmed Assiri Ali Hussain Alnahwi. "PHARMACODYNAMICS AND PHARMACOKINETICS OF DIURETIC AGENTS." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 12 (2018): 14266–70. https://doi.org/10.5281/zenodo.1974245.

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<em>Diuretic agents are commonly prescribed medications in various diseases such as hypertension, congestive heart disease, and several causes of oedema.</em> Different types of diuretics are currently available and, though their somehow closely similar mechanisms of action, their final effect depends primarily on their pharmacokinetic and pharmacodynamic properties. <em>Pharmacokinetics describe delivering the drug to the site of action in certain concentrations and at a certain time, whilst pharmacodynamics implies the final response of the diuretic agent at the active site of response. Unde
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Kamp, Jasper, Erik Olofsen, Thomas K. Henthorn, Monique van Velzen, Marieke Niesters, and Albert Dahan. "Ketamine Pharmacokinetics." Anesthesiology 133, no. 6 (2020): 1192–213. http://dx.doi.org/10.1097/aln.0000000000003577.

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Background Several models describing the pharmacokinetics of ketamine are published with differences in model structure and complexity. A systematic review of the literature was performed, as well as a meta-analysis of pharmacokinetic data and construction of a pharmacokinetic model from raw data sets to qualitatively and quantitatively evaluate existing ketamine pharmacokinetic models and construct a general ketamine pharmacokinetic model. Methods Extracted pharmacokinetic parameters from the literature (volume of distribution and clearance) were standardized to allow comparison among studies
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Jeong, Seung-Hyun, Ji-Hun Jang, and Yong-Bok Lee. "Pharmacokinetic Comparison between Methotrexate-Loaded Nanoparticles and Nanoemulsions as Hard- and Soft-Type Nanoformulations: A Population Pharmacokinetic Modeling Approach." Pharmaceutics 13, no. 7 (2021): 1050. http://dx.doi.org/10.3390/pharmaceutics13071050.

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The purpose of this study was to identify and explore the differences in pharmacokinetics between different nanoformulations. This was done by comparing the pharmacokinetics of methotrexate-loaded nanoparticles [poly(lactic-co-glycolic acid); size of 163.70 ± 10.25 nm] and nanoemulsions (olive oil and Labrasol; size of 173.77 ± 5.76 nm), which represent hard- and soft-type nanoformulations, respectively. In addition, the population pharmacokinetic modeling approach as a useful tool for the comparison of pharmacokinetics between nanoformulations was newly proposed through this study. Significan
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Grzegorzewski, Jan, Janosch Brandhorst, Kathleen Green, et al. "PK-DB: pharmacokinetics database for individualized and stratified computational modeling." Nucleic Acids Research 49, no. D1 (2020): D1358—D1364. http://dx.doi.org/10.1093/nar/gkaa990.

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Abstract A multitude of pharmacokinetics studies have been published. However, due to the lack of an open database, pharmacokinetics data, as well as the corresponding meta-information, have been difficult to access. We present PK-DB (https://pk-db.com), an open database for pharmacokinetics information from clinical trials. PK-DB provides curated information on (i) characteristics of studied patient cohorts and subjects (e.g. age, bodyweight, smoking status, genetic variants); (ii) applied interventions (e.g. dosing, substance, route of application); (iii) pharmacokinetic parameters (e.g. cle
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Tang, Bo-Hao, Yue-E. Wu, Chen Kou, et al. "Population Pharmacokinetics and Dosing Optimization of Amoxicillin in Neonates and Young Infants." Antimicrobial Agents and Chemotherapy 63, no. 2 (2018): e02336-18. http://dx.doi.org/10.1128/aac.02336-18.

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ABSTRACT Amoxicillin is widely used to treat bacterial infections in neonates. However, considerable intercenter variability in dosage regimens of antibiotics exists in clinical practice. The pharmacokinetics of amoxicillin has been described in only a few preterm neonates. Thus, we aimed to evaluate the population pharmacokinetics of amoxicillin through a large sample size covering the entire age range of neonates and young infants and to establish evidence-based dosage regimens based on developmental pharmacokinetics-pharmacodynamics. This is a prospective, multicenter, pharmacokinetic study
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Li, Qiao, Yan Yang, Ting Zhou, et al. "A Compositive Strategy to Study the Pharmacokinetics of TCMs: Taking Coptidis Rhizoma, and Coptidis Rhizoma-Glycyrrhizae Radix et Rhizoma as Examples." Molecules 23, no. 8 (2018): 2042. http://dx.doi.org/10.3390/molecules23082042.

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Pharmacokinetic studies are crucial for elucidating the effective constituents and formula compatibility of traditional Chinese medicines (TCMs). However, studies have usually been limited to single dosages and detection of systemic blood concentrations. To obtain comprehensive pharmacokinetic information, here we propose a multi-dosage and multi-sampling (blood from portal vein or systemic circulation, and liver) strategy to comparatively study the pharmacokinetics of multi-form TCMs, i.e., pure constituents, TCMs, or TCM formula extracts. Based on this strategy, we studied the pharmacokineti
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Toja-Camba, Francisco José, Nerea Gesto-Antelo, Olalla Maroñas, et al. "Review of Pharmacokinetics and Pharmacogenetics in Atypical Long-Acting Injectable Antipsychotics." Pharmaceutics 13, no. 7 (2021): 935. http://dx.doi.org/10.3390/pharmaceutics13070935.

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Over the last two decades, pharmacogenetics and pharmacokinetics have been increasingly used in clinical practice in Psychiatry due to the high variability regarding response and side effects of antipsychotic drugs. Specifically, long-acting injectable (LAI) antipsychotics have different pharmacokinetic profile than oral formulations due to their sustained release characteristics. In addition, most of these drugs are metabolized by CYP2D6, whose interindividual genetic variability results in different metabolizer status and, consequently, into different plasma concentrations of the drugs. In t
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Jacobson, J. M., M. Davidian, P. M. Rainey, R. Hafner, R. H. Raasch, and B. J. Luft. "Pyrimethamine pharmacokinetics in human immunodeficiency virus-positive patients seropositive for Toxoplasma gondii." Antimicrobial Agents and Chemotherapy 40, no. 6 (1996): 1360–65. http://dx.doi.org/10.1128/aac.40.6.1360.

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Pyrimethamine pharmacokinetics were studied in 11 human immunodeficiency virus (HIV)-positive patients who were seropositive for exposure to Toxoplasma gondii and were taking zidovudine (AIDS Clinical Trials Group Protocol 102). Pyrimethamine was administered at 50 mg daily for 3 weeks to achieve steady state, and pharmacokinetic profiles were determined after administration of the last dose. Noncompartmental and compartmental analyses were performed. Population pharmacokinetic analysis assuming a one-compartment model yielded the following estimates: area under the 24-h concentration-time cur
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Albitar, Orwa, Sabariah Noor Harun, Hadzliana Zainal, Baharudin Ibrahim, and Siti Maisharah Sheikh Ghadzi. "Population Pharmacokinetics of Clozapine: A Systematic Review." BioMed Research International 2020 (January 8, 2020): 1–10. http://dx.doi.org/10.1155/2020/9872936.

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Background and Objective. Clozapine is a second-generation antipsychotic drug that is considered the most effective treatment for refractory schizophrenia. Several clozapine population pharmacokinetic models have been introduced in the last decades. Thus, a systematic review was performed (i) to compare published pharmacokinetics models and (ii) to summarize and explore identified covariates influencing the clozapine pharmacokinetics models. Methods. A search of publications for population pharmacokinetic analyses of clozapine either in healthy volunteers or patients from inception to April 20
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Dissertations / Theses on the topic "Pharmacokinetics"

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Chigutsa, Emmanuel. "Population pharmacokinetics and pharmacokinetic-pharmacodyamic modeling of antitubercular drugs." Doctoral thesis, University of Cape Town, 2013. http://hdl.handle.net/11427/3275.

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Includes abstract.<br>Includes bibliographical references.<br>The pharmacokinetics of rifampicin, isoniazid, pyrazinamide and ethambutol in 78 patients with tuberculosis were described using non-linear mixed effects modeling. Pharmacodynamic data was comprised of weekly sputum liquid culture (using mycobacterial growth indicator tubes) time to detection results from 144 patients during the first 2 months of treatment. The effect of drug exposure on patient outcomes was investigated. To determine the adequacy of ofloxacin drug exposure, the probability of attaining the required area-under-the-c
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Ulrich-Oppliger, Brigitte Madeleine. "Pharmacokinetics /." Bern, 1992. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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Charter, Mark Keith. "Maximum entropy pharmacokinetics." Thesis, University of Cambridge, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.316691.

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Smith, Jennifer Lisa. "Pharmacokinetics of methylamines." Thesis, Massachusetts Institute of Technology, 1992. http://hdl.handle.net/1721.1/12906.

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Khosravan, Reza. "Nonlinear pharmacokinetics of diltiazem." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0030/NQ46865.pdf.

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Al-Mustafa, Z. H. "Methotrexate pharmacokinetics and toxicity." Thesis, University of Newcastle Upon Tyne, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.383988.

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Woodhouse, Jennifer Ann. "Plutonium pharmacokinetics and blood biochemistry." Thesis, University of Central Lancashire, 1997. http://clok.uclan.ac.uk/20148/.

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Since its discovery in the early 1940s the element plutonium has been seen by mankind as both an opportunity and a threat. As a radioactive nuclide plutonium presents health hazards in its handling and if mankind is to make the most of this element's potential benefits it is essential that these hazards be understood. Both overestimation and underestimation of these hazards are damaging to its proper utilisation. Many studies have been carried out to determine the effects of plutonium exposure and a broad picture of the biological behaviour of plutonium has been built up. Radiological protecti
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Smith, Adam John. "Modulating the Pharmacokinetics of Bioflavonoids." Scholar Commons, 2012. http://scholarcommons.usf.edu/etd/4226.

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One of the largest obstacles in drug development is to overcome solubility and bioavailability problems. Preformulation strategies such as nanoparticle formation are often employed but sometimes create new issues and are limited in their effectiveness and applications. Since the majority of drugs are marketed and sold as solid forms, drug delivery systems are not always desirable. This is where solid-state chemistry becomes important. Traditional solid-state chemistry approaches are often successful but are sometimes too restrictive and cannot be applied to certain compounds. Cocrystals h
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Harper, Kenneth W. "Pharmacokinetics of methohexitone and midazolam." Thesis, Queen's University Belfast, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.254195.

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Evans, Gary Lee. "Pharmacokinetics and metabolism of lacidipine." Thesis, University of Hertfordshire, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.387196.

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Books on the topic "Pharmacokinetics"

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Pecile, A., and A. Rescigno, eds. Pharmacokinetics. Springer US, 1988. http://dx.doi.org/10.1007/978-1-4684-5463-5.

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Riviere, Jim E. Comparative pharmacokinetics. Wiley-Blackwell, 2011.

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Krishna, Devarakonda Rama, and Ulrich Klotz. Clinical Pharmacokinetics. Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-642-75623-8.

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Riviere, Jim E. Comparative Pharmacokinetics. Wiley-Blackwell, 2011. http://dx.doi.org/10.1002/9780470959916.

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Davies, Neal M., and Jaime A. Yáñez, eds. FLAVONOID PHARMACOKINETICS. John Wiley & Sons, Inc., 2012. http://dx.doi.org/10.1002/9781118468524.

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Wu, Baojian, Danyi Lu, and Dong Dong, eds. Circadian Pharmacokinetics. Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-8807-5.

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J, Breen Philip, ed. Basic pharmacokinetics. Pharmaceutical Press, 2009.

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1943-, Shroot B., Schaefer H. 1935-, and Centre international de recherches dermatologiques., eds. Skin pharmacokinetics. Karger, 1987.

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Källén, Anders. Computational pharmacokinetics. Chapman & Hall/CRC, 2008.

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Källén, Anders. Computational pharmacokinetics. Taylor & Francis, 2007.

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Book chapters on the topic "Pharmacokinetics"

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Gladtke, Erich. "History of Pharmacokinetics." In Pharmacokinetics. Springer US, 1988. http://dx.doi.org/10.1007/978-1-4684-5463-5_1.

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Metzler, Carl M. "Equivalence of Bioavailability and Efficacy in Drug Testing." In Pharmacokinetics. Springer US, 1988. http://dx.doi.org/10.1007/978-1-4684-5463-5_10.

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Thakur, Ajit K. "Modeling and Risk Assessment of Carcinogenic Dose-Response." In Pharmacokinetics. Springer US, 1988. http://dx.doi.org/10.1007/978-1-4684-5463-5_11.

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Bass, Ludvik, and Susan M. Pond. "The Puzzle of Rates of Cellular Uptake of Protein-Bound Ligands." In Pharmacokinetics. Springer US, 1988. http://dx.doi.org/10.1007/978-1-4684-5463-5_12.

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Mordenti, Joyce. "A Pharmacokinetic Equation Guide for Clinicians." In Pharmacokinetics. Springer US, 1988. http://dx.doi.org/10.1007/978-1-4684-5463-5_13.

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Wagner, John G. "Pharmacokinetic Studies in Man." In Pharmacokinetics. Springer US, 1988. http://dx.doi.org/10.1007/978-1-4684-5463-5_14.

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Breuer, Francesco. "Metabolic Models in Radiation Protection." In Pharmacokinetics. Springer US, 1988. http://dx.doi.org/10.1007/978-1-4684-5463-5_15.

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Beck, James S. "Conceptual Foundations and Uses of Models in Pharmacokinetics." In Pharmacokinetics. Springer US, 1988. http://dx.doi.org/10.1007/978-1-4684-5463-5_2.

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Rescigno, Aldo, and Ajit K. Thakur. "Development of Compartmental Concepts." In Pharmacokinetics. Springer US, 1988. http://dx.doi.org/10.1007/978-1-4684-5463-5_3.

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Thakur, Ajit K. "Modeling of Pharmacokinetic Data." In Pharmacokinetics. Springer US, 1988. http://dx.doi.org/10.1007/978-1-4684-5463-5_4.

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Conference papers on the topic "Pharmacokinetics"

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Li, Ying, Xiao Deng, Jingsong Lv, Hongyang Chen, and Yao Yang. "LEMTL: Enhancing the pharmacokinetic predictions of multitask learning with existing pharmacokinetics." In 2024 IEEE International Conference on Bioinformatics and Biomedicine (BIBM). IEEE, 2024. https://doi.org/10.1109/bibm62325.2024.10822596.

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Lin, Ke, Xiangfeng Wen, Zhisong Qin, and Wenying Chen. "Pharmacokinetics-guided breast tumor segmentation method." In 2025 5th International Symposium on Computer Technology and Information Science (ISCTIS). IEEE, 2025. https://doi.org/10.1109/isctis65944.2025.11065954.

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Evans, Conor L. "Quantifying human cutaneous pharmacokinetics." In Advanced Chemical Microscopy for Life Science and Translational Medicine 2021, edited by Garth J. Simpson, Ji-Xin Cheng, and Wei Min. SPIE, 2021. http://dx.doi.org/10.1117/12.2577713.

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Dol, F., G. Houin, D. Dupouy, et al. "THE PHARMACOKINETICS OF 125-I DERMATAN SULFATE IN THE RABBIT." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643243.

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We have determined the main pharmacokinetic parameters of dermatan sulfate (DS), a catalyst of IIa-heparin cofactor II (HC II) interaction which presents antithrombotic properties in the rabbit. DS (Pharmuka, France) was conjugated with SHPP and iodinated using the chloramine T method. The labelled derivative had the same MW distribution and biological activities than.the native one. Rabbits were injected by 5 ucies of 125I-DS (0.6 ug) and increasing doses of unlabelled DS. Serial blood samples were collected to measure cpm disappearance and, in some cases, residual biological activity was det
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Johansson, Ann, Jenny Svensson, Stefan Andersson-Engels, et al. "mTHPC pharmacokinetics following topical administration." In Biomedical Optics 2006, edited by Gerard L. Coté and Alexander V. Priezzhev. SPIE, 2006. http://dx.doi.org/10.1117/12.647602.

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Kasyanova, V. V., and I. N. Bazhukova. "Modeling of cerium oxide nanoparticles pharmacokinetics." In THE 2ND INTERNATIONAL CONFERENCE ON PHYSICAL INSTRUMENTATION AND ADVANCED MATERIALS 2019. AIP Publishing, 2020. http://dx.doi.org/10.1063/5.0032208.

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Lee, Seok-Yong, Chang-Keun Cho, Pureum Kang, Eunvin Ko, and Chou Yen Mu. "Physiologically Based Pharmacokinetic (PBPK) Modeling to Predict the Pharmacokinetics of Irbesartan in DifferentCYP2C9Genotypes." In ASPET 2023 Annual Meeting Abstracts. American Society for Pharmacology and Experimental Therapeutics, 2023. http://dx.doi.org/10.1124/jpet.122.508580.

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Ahmed, Nusrat, Yashpal S. Chhonker, Valentina Shakhnovich, Veronica Williams, and Daryl J. Murry. "Development of a Physiologically Based Pharmacokinetic Model for Predicting Midazolam Pharmacokinetics in a Pediatric Population with Obesity." In ASPET 2024 Annual Meeting Abstract. American Society for Pharmacology and Experimental Therapeutics, 2024. http://dx.doi.org/10.1124/jpet.404.938920.

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Keith, Godfrey,. "Modelling the Double Peak Phenomenon in Pharmacokinetics." In Modeling and Control in Biomedical Systems, edited by Rees, Stephen, chair Andreassen, Steen and Andreassen, Steen. Elsevier, 2009. http://dx.doi.org/10.3182/20090812-3-dk-2006.00022.

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Feizpour, Amin, Louise Bastholm, Troels T. Marstrand, and Conor L. Evans. "Label-free Quantification of Pharmacokinetics in Skin." In Bio-Optics: Design and Application. OSA, 2019. http://dx.doi.org/10.1364/boda.2019.jw3c.1.

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Reports on the topic "Pharmacokinetics"

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Hawkins, David R. Determination of Drug Pharmacokinetics and Metabolic Profile. Volume 2. Defense Technical Information Center, 1988. http://dx.doi.org/10.21236/ada192428.

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Heinen, Jessica. Process of Modeling Pharmacokinetics Using Nonlinear Mixed-Effect Models. Iowa State University, 2020. http://dx.doi.org/10.31274/cc-20240624-1156.

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Gurley, L. R., K. O. Umbarger, J. M. Kim, E. M. Bradbury, and B. E. Lehnert. Staurosporine analysis and its pharmacokinetics in the blood of rats. Office of Scientific and Technical Information (OSTI), 1994. http://dx.doi.org/10.2172/10160825.

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Cheung, Nai-Kong V., Shakeel Modak, Yukang Lin, et al. Pharmacokinetics of Genetically Engineered Antibody Forms Using Positron Emission Tomography. Office of Scientific and Technical Information (OSTI), 2004. http://dx.doi.org/10.2172/828873.

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Karna, Shravya, and Alex Konstantatos. Methadone and Buprenorphine for Management of Acute Postoperative Pain. World Federation of Societies of Anaesthesiologists, 2022. http://dx.doi.org/10.28923/atotw.472.

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Methadone and buprenorphine have shown to decrease total opioid requirements and attenuate side effects post operatively. Methadone’s pharmacokinetics properties make it a potent analgesic whilst sublingual and transdermal buprenorphine is an excellent step-down to parenteral analgesia.
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Kamimori, Gary H. Effect of Time of Menstrual Cycle on Drug Pharmacokinetics and Pharmacodynamics. Defense Technical Information Center, 2001. http://dx.doi.org/10.21236/ada409105.

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Kornhauser, David M., Brent G. Petty, and Paul S. Lietman. Pharmacokinetics and Pharmacodynamics of Sustained Low-Dose Intravenous Infusions of Pyridostigmine. Defense Technical Information Center, 1993. http://dx.doi.org/10.21236/ada530411.

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Carpenter, Hillary M., and Lawrence R. Curtis. Pharmacokinetics of Lipophilic Agents Following Preexposure: Non-Cytochrome P-450 Mediated Mechanisms. Defense Technical Information Center, 1990. http://dx.doi.org/10.21236/ada225356.

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Gorden, Patrick J., Michael D. Kleinhenz, Larry W. Wulf, et al. Altered Plasma Pharmacokinetics of Ceftiofur Hydrochloride in Cows Affected with Severe Clinical Mastitis. Iowa State University, 2016. http://dx.doi.org/10.31274/ans_air-180814-216.

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Puthanakit, Thanyawee, Kiat Ruxrungtham, Chitsanu Pancharoen, Jintanat Ananworanich, Torsak Burunupradah, and Arunee Klinklom. Pharmacokinetics of low-dose lopinavir/ritonavir tablet formulation in HIV-1 infected children. Chulalongkorn University, 2010. https://doi.org/10.58837/chula.res.2010.14.

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Methods: This was an open-label, cross-over study of 24 HIV-infected children with HIV RNA &lt; 50 copies/ml comparing PK parameter of standard dose LPV/r and low dose of LPV/r for 4 weeks. LPV dosage was prescribed by body weight band; 25~35 kg: LPV/r 300/75 vs. 200/50 mg, &gt; 35 kg 400/100 vs. 300/75 mg. Glood samples were drawn at 0 (pre-dose), 2,4,6,8, 10 and 12 hours. Plasma concentrations of LPV and RTV were measured by HPLC method. The acceptable C12h is &gt; 1 mg/L. The HIV RNA was measured at week 12 after switch back to standard dose for 4 weeks. Results: Twenty four children were i
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