Log in

Relevant bibliographies by topics / Pharmacokinetics Drugs Drugs / Dissertations / Theses

To see the other types of publications on this topic, follow the link: Pharmacokinetics Drugs Drugs.

Dissertations / Theses on the topic 'Pharmacokinetics Drugs Drugs'

Author: Grafiati

Published: 4 June 2021

Last updated: 4 February 2022

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 dissertations / theses for your research on the topic 'Pharmacokinetics Drugs Drugs.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.

1

Chigutsa, Emmanuel. "Population pharmacokinetics and pharmacokinetic-pharmacodyamic modeling of antitubercular drugs." Doctoral thesis, University of Cape Town, 2013. http://hdl.handle.net/11427/3275.

Full text

Abstract:

Includes abstract.<br>Includes bibliographical references.<br>The pharmacokinetics of rifampicin, isoniazid, pyrazinamide and ethambutol in 78 patients with tuberculosis were described using non-linear mixed effects modeling. Pharmacodynamic data was comprised of weekly sputum liquid culture (using mycobacterial growth indicator tubes) time to detection results from 144 patients during the first 2 months of treatment. The effect of drug exposure on patient outcomes was investigated. To determine the adequacy of ofloxacin drug exposure, the probability of attaining the required area-under-the-c

APA, Harvard, Vancouver, ISO, and other styles

2

Olsén, Lena. "Drugs in horses : pharmacokinetics and pharmacodynamics /." Uppsala : Dept. of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, 2007. http://epsilon.slu.se/200737.pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Song, Di. "Bladder tissue pharmacokinetics of anticancer drugs /." The Ohio State University, 1996. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487940308433249.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Wang, Shining. "DRUG DEVELOPMENT OF TARGETED ANTICANCER DRUGS BASED ON PK/PD INVESTIGATIONS." Diss., Temple University Libraries, 2008. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/2535.

Full text

Abstract:

Pharmaceutics<br>Ph.D.<br>EGFR inhibitors, such as gefitinib, are examples of targeted anticancer drugs whose drug sensitivity is related to gene mutations that adds a pharmacogenetic [PG] dimension to any pharmacokinetic [PK] and pharmacodynamic [PD] analysis. The goal of this project was to characterize the PK/PD properties of gefitinib in tumors and then apply these results to design rational drug design regimens, and provide a foundation for future studies with EGFR inhibitors. Progressions of in vitro and in vivo studies were completed to understand the PK and PD behavior of gefitinib. In

APA, Harvard, Vancouver, ISO, and other styles

5

James, Devona Gwen. "The degradation of drugs in formaldehyde." Morgantown, W. Va. : [West Virginia University Libraries], 1999. http://etd.wvu.edu/templates/showETD.cfm?recnum=1149.

Full text

Abstract:

Thesis (M.S.)--West Virginia University, 1999.<br>Title from document title page. Document formatted into pages; contains xvi, 100 p. : ill. Vita. Includes abstract. Includes bibliographical references (p. 98-99).

APA, Harvard, Vancouver, ISO, and other styles

6

Yeh, Teng-Kuang. "Pharmacokinetics of anti-aids and anti-cancer drugs : implications on drug delivery and drug interaction /." The Ohio State University, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=osu148654688938101.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Mashile, Tumelo Rameleko. "Enantioanalysis of pharmaceutical compounds." Pretoria : [s.n.], 2005. http://upetd.up.ac.za/thesis/available/etd-02222007-195248.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Reis, Margareta. "Pharmacokinetics of antidepressant drugs : naturalistic and clinical trials /." Linköping : Univ, 2003. http://www.bibl.liu.se/liupubl/disp/disp2003/med783s.pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Hammann, Felix. "Prediction of transport, pharmacokinetics, and effect of drugs /." Basel : [s.n.], 2009. http://edoc.unibas.ch/diss/DissB_8905.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Zhang, Yuan. "The role of drug disposition genes for variability in the pharmacokinetics of antiretroviral drugs." Thesis, University of Liverpool, 2013. http://livrepository.liverpool.ac.uk/9075/.

Full text

Abstract:

The failure of highly active antiretroviral therapy may be due to pharmacological factors such as drug transporters and metabolism enzymes. Drug transporters and metabolism enzymes played complementary roles in drug absorption, distribution, metabolism and excretion by biotransformation and counter-transport, particularly in the intestine while nuclear receptors as transcription factors regulate the expression of drug transporters and metabolism enzymes. In this thesis, a positive correlation between nuclear receptors expression and the expression of ABC transporters and OATP transporters in i

APA, Harvard, Vancouver, ISO, and other styles

11

Kloprogge, Frank Lodewijk. "Pharmacokinetics and pharmacodynamics of antimalarial drugs in pregnant women." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:79ce1a37-3ba2-45e4-9f80-0692a66837f1.

Full text

Abstract:

Malaria is the most important parasitic disease in man and it kills approximately 2,000 people each day. Pregnant women are especially vulnerable to malaria with increased incidence and mortality rates. There are indications that pregnancy alters the pharmacokinetic properties of many antimalarial drugs. This is worrisome as lower drug exposures might result in lowered efficacy and lower drug exposures can also accelerate the development and spread of resistant parasites. The aim of this research was to study the pharmacokinetics and pharmacodynamics of the most commonly used drugs for the tre

APA, Harvard, Vancouver, ISO, and other styles

12

Zhang, Jing Lu. "Big data analysis of solid dispersion researches from 1980 to 2015." Thesis, University of Macau, 2018. http://umaclib3.umac.mo/record=b3952169.

Full text

APA, Harvard, Vancouver, ISO, and other styles

13

Wattanatorn, Wiboon. "Pharmacokinetics of 5-fluorouracil in cancer patients." Thesis, Robert Gordon University, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.389482.

Full text

APA, Harvard, Vancouver, ISO, and other styles

14

Patel, Fathima. "The development and assessment of a generic carbamazepine sustained release dosage form." Thesis, Rhodes University, 2006. http://eprints.ru.ac.za/1339/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

15

Winkler, Julia. "Pharmacokinetics and pharmacodynamics of corticosteroid prodrugs and soft drugs." [Gainesville, Fla.] : University of Florida, 2004. http://purl.fcla.edu/fcla/etd/UFE0006942.

Full text

Abstract:

Thesis (Ph.D.)--University of Florida, 2004.<br>Typescript. Title from title page of source document. Document formatted into pages; contains 157 pages. Includes Vita. Includes bibliographical references.

APA, Harvard, Vancouver, ISO, and other styles

16

Skeith, Kenneth J. "The clinical pharmacokinetics of 2-arylpropionic nonsteroidal antiinflammatory drugs." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0017/NQ46920.pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

17

Priston, Melanie Jane. "Studies on the pharmacokinetics and metabolism of mitozantrone." Thesis, University of Exeter, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.303766.

Full text

APA, Harvard, Vancouver, ISO, and other styles

18

Demirbas, Ucpinar Sibel. "Oligonucleotides and protease inhibitors transport across CaCo-2 cell monolayers-permeability effects of dimethylsulfoxide and citicholine /." Full text (PDF) from UMI/Dissertation Abstracts International, 2000. http://wwwlib.umi.com/cr/utexas/fullcit?p3004252.

Full text

APA, Harvard, Vancouver, ISO, and other styles

19

Eriksson, Tommy. "Pharmacokinetics of the enantionmers of thalidomide." Malmö : Lund : Malmö University Hospital ; Lund University, 1997. http://catalog.hathitrust.org/api/volumes/oclc/68945032.html.

Full text

APA, Harvard, Vancouver, ISO, and other styles

20

Elliott, Christopher T. "Detection, pharmacokinetics and molecular mimicry of beta agonists." Thesis, Queen's University Belfast, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.247342.

Full text

APA, Harvard, Vancouver, ISO, and other styles

21

McCallion, Orla N. M. "The pharmacokinetics and pharmacodynamics of drugs used to treat asthma." Thesis, Queen's University Belfast, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.333800.

Full text

APA, Harvard, Vancouver, ISO, and other styles

22

Benchaoui, Hafid Abdelaali. "Factors affecting the pharmacokinetics, metabolism and efficacy of anthelmintic drugs." Thesis, University of Glasgow, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.284569.

Full text

APA, Harvard, Vancouver, ISO, and other styles

23

Carmichael, Samantha Jane. "Optimisation of study design in the pharmacokinetics of anticancer drugs." Thesis, University of Edinburgh, 2001. http://hdl.handle.net/1842/23290.

Full text

Abstract:

"Optimal sampling strategies" are based upon the concept of 'information-rich' times within a concentration-time profile. In this thesis, the selection of optimal sampling times was based on sensitivity analysis and applied to the one and two-compartment PK models. Simulation studies were used to show that parameter estimates obtained using an optimal design method with a reduced number of samples were as good as, if not better than, those obtained from PK studies in which the sampling times were selected empirically. In addition, the effect of adding sampling windows around the "optimal" time

APA, Harvard, Vancouver, ISO, and other styles

24

Hu, Leijun. "Suramin pharmacokinetics after regional or systemic administration." Connect to resource, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1114449390.

Full text

APA, Harvard, Vancouver, ISO, and other styles

25

Abd, Ghani Ramli. "The relationship between the pharmacokinetics of carboplatin and its toxicity." Thesis, University of Brighton, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.282926.

Full text

APA, Harvard, Vancouver, ISO, and other styles

26

Sood, Pooja. "Assessment of pharmacokinetics and pharmacodynamics of psychoactive drugs using brain microdialysis." Thesis, University of Leicester, 2010. http://hdl.handle.net/2381/8820.

Full text

Abstract:

In order to assess pharmacokinetics and pharmacodynamics (PK/PD) accurately, it is necessary to obtain measurements of the absolute concentrations of compounds in the brain. A major shortcoming of using microdialysis to measure PK/PD is that microdialysis measurements do not give us absolute concentrations of solutes in the brain, since the relationship between dialysate concentrations and true extracellular fluid (ecf) concentrations surrounding the probe is unknown. Several methods have been devised to circumvent this problem. The present study employed a novel method, MetaQuant (MQ) microdi

APA, Harvard, Vancouver, ISO, and other styles

27

Walton, Michael Ian. "The effects of hyperthermia on the pharmacokinetics of selected anticancer drugs." Thesis, University of Cambridge, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.254220.

Full text

APA, Harvard, Vancouver, ISO, and other styles

28

Schmitt, Veronika. "Sampling and pharmacokinetics of skin interstitial fluid for therapeutically monitored drugs." Thesis, University of British Columbia, 2015. http://hdl.handle.net/2429/56176.

Full text

Abstract:

To guide therapeutic decision making, the pharmacokinetics (PK) of certain toxic drugs are typically studied in blood. A drug’s blood concentration is thus acting as a surrogate for its target site concentration. However, a drug’s target is often extravascular and measuring tissue concentrations would be more meaningful. Furthermore, blood sampling is painful and can be challenging for some patients such as children, seriously ill, and old patients; it is, however, currently the standard method for drug testing. Current research suggests that a tissue fluid called interstitial fluid (ISF) can

APA, Harvard, Vancouver, ISO, and other styles

29

Patel, Chirag G. "The pharmacokinetics and pharmacodynamics of mycophenolic acid in kidney transplant recipients /." View online ; access limited to URI, 2006. http://0-wwwlib.umi.com.helin.uri.edu/dissertations/fullcit/3239911.

Full text

APA, Harvard, Vancouver, ISO, and other styles

30

Segrave, Alicia Maree. "An investigation of the pharmacokinetics and lymphatic transport of recombinant human leukaemia inhibitory factor." Monash University, Dept. of Pharmaceutics, 2004. http://arrow.monash.edu.au/hdl/1959.1/9389.

Full text

APA, Harvard, Vancouver, ISO, and other styles

31

Wang, Jie Stamey James D. "Sample size determination for Emax model, equivalence / non-inferiority test and drug combination in fixed dose trials." Waco, Tex. : Baylor University, 2008. http://hdl.handle.net/2104/5182.

Full text

APA, Harvard, Vancouver, ISO, and other styles

32

Mogoa, Eddy Geoffrey Mosoti. "Effects of environmental temperature on pharmacokinetics of, and clinical response to xylazine in goats." Pretoria : [s.n.], 2009. http://upetd.up.ac.za/thesis/available/etd-01052007-110131/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

33

Siebert, Gerhard A. "Disposition pharmacokinetics and effects of solutes and drugs in perfused organ systems /." [St. Lucia, Qld.], 2004. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe18644.pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

34

Dunagan, Fiona M. "Non-steroidal anti-inflammatory drugs : pharmacokinetics and clinical response in rheumatoid arthritis." Thesis, University of Glasgow, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.236497.

Full text

APA, Harvard, Vancouver, ISO, and other styles

35

Lilja, Jari. "Effects of grapefruit juice on the pharmacokinetics of selected CYP3A4 substrate drugs." Helsinki : University of Helsinki, 2001. http://ethesis.helsinki.fi/julkaisut/laa/kliin/vk/lilja/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

36

McKellar, Quintin Archibald. "Pharmacokinetics and pharmacodynamics of anti-infective and anti-inflammatory drugs in animals." Thesis, University of Glasgow, 2001. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.395088.

Full text

APA, Harvard, Vancouver, ISO, and other styles

37

Krishnamoorthy, Mahesh Kumaar. "Effect of Retinal Permeability Variation on Pharmacokinetics of Drugs in the Eye." University of Cincinnati / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1163578450.

Full text

APA, Harvard, Vancouver, ISO, and other styles

38

Zhang, Peng. "Mesoporous magnesium carbonate as a drug delivery vehicle for stabilising amorphous drugs and regulating their release rate." Doctoral thesis, Uppsala universitet, Nanoteknologi och funktionella material, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-303832.

Full text

Abstract:

In today’s drug discovery, the number of candidate drugs based on new molecular entities with poor aqueous solubility is increasing. Since poor aqueous solubility of an active pharmaceutical ingredients (APIs) is associated with low bioavailability and thus limite their therapeutic effect, this is often a great challenge in the development of new drugs when oral administration is the preferred route of administration. A number of different strategies have been developed to circumvent this problem where salt formulations of an API is the most widely employed method. However, new strategies are

APA, Harvard, Vancouver, ISO, and other styles

39

Thörn, Helena Anna. "First-pass Intestinal Metabolism of Drugs : Experiences from in vitro, in vivo and simulation studies." Doctoral thesis, Uppsala universitet, Institutionen för farmaci, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-165514.

Full text

Abstract:

The bioavailability of a drug can be described as the fraction of an orally administered dose that reaches the systemic circulation and is often limited by first-pass metabolism in the gut and the liver. It is important to have knowledge about these processes since the systemic blood drug concentration is tightly connected to the effect of the drug. The general aim of this project was to quantitatively examine the role of the intestine in relation to the liver in first-pass metabolism of orally administered drugs. The first-pass metabolism of verapamil and raloxifene was investigated in detail

APA, Harvard, Vancouver, ISO, and other styles

40

Onthank, David C. "Prediction of "First Dose in Human" for radiopharmaceuticals/imaging agents based on allometric scaling of pharmacokinetics in pre-clinical animal models." Link to electronic dissertation, 2005. http://www.wpi.edu/Pubs/ETD/Available/etd-011006-132234/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

41

Li, Nan, and 李楠. "The influence of partial hepatectomy on desmethyldiazepam formation and elimination after diazepam infusion in Chinese." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B31245687.

Full text

APA, Harvard, Vancouver, ISO, and other styles

42

Calvete, Joanne Amanda. "Pre-clinical studies with the novel colorectal cancer targeted immunotoxin, ICI D0490." Thesis, University of Newcastle Upon Tyne, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.336268.

Full text

APA, Harvard, Vancouver, ISO, and other styles

43

Webb, Hayley Margaret. "Investigation of pharmacokinetics and thioether metabolites to assess bioactivation and toxicity of drugs." Thesis, University of Liverpool, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.569256.

Full text

Abstract:

ADRs are a major complication of drug therapy and are one of the main causes of attrition in drug development. Bioactivation of drugs to CRMs is believed to be a crucial step in the development of many direct and immune-mediated ADRs. FS, a furan containing diuretic drug, has been shown to produce massive hepatic necrosis in mice through bioactivation of the furan ring to a reactive epoxide intermediate. A thiophene analogue of FS (TP A) has been synthesized in order to compare the heterocyclic moieties in the same biological environment. NVP, used for the treatment of HIV -1 infection, can ca

APA, Harvard, Vancouver, ISO, and other styles

44

Potter, Timothy. "Pharmacokinetics and pharmacodynamics of antimicrobial drugs used in the treatment of calf pneumonia." Thesis, Royal Veterinary College (University of London), 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.559067.

Full text

APA, Harvard, Vancouver, ISO, and other styles

45

Tong, Xin. "The pharmacokinetics and neuropharmacological action of the new antiepileptic drugs vigabatrin and levetiracetam." Thesis, University College London (University of London), 2007. http://discovery.ucl.ac.uk/1445126/.

Full text

Abstract:

Epilepsy affects approximately 1% of the world population and is the most serious neurological conditions. In the UK, 30-35,000 new cases of epilepsy are diagnosed each year, resulting in a prevalence of 300,000 nationwide. There is significant need for new drug treatments. Yet we have a poor understanding of how many of these drugs mediate their antiepileptic effect, and how and where they are distributed within the brain. This thesis sought to investigate the pharmacokinetic and neuropharmacokinetic inter-relationship and the neuropharmacology of two new antiepileptic drugs, vigabatrin and l

APA, Harvard, Vancouver, ISO, and other styles

46

Sandall, Joanne Margaret. "A study of factors affecting the pharmacokinetics of drugs in the paediatric population." Thesis, Queen's University Belfast, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.479329.

Full text

APA, Harvard, Vancouver, ISO, and other styles

47

Landoni, Maria Fabiana. "Pharmacokinetics and pharmacodynamics of non steroidal anti-inflammatory drugs in horses and calves." Thesis, Royal Veterinary College (University of London), 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.281664.

Full text

APA, Harvard, Vancouver, ISO, and other styles

48

Huang, Yi Fei. "Myocardial pharmacokinetics and pharmacodynamics in the sheep /." Title page, contents and abstract only, 1991. http://web4.library.adelaide.edu.au/theses/09PH/09phh8742.pdf.

Full text

Abstract:

Thesis (Ph. D.)--University of Adelaide, Dept. of Anaesthesia and Intensive Care, 1992.<br>Accompanying diskette contains data of Chapters 3, 4, 5, 7, 8 and 9 (ASCII). Includes bibliographical references (leaves 177-207).

APA, Harvard, Vancouver, ISO, and other styles

49

Friberg, Lena E. "Pharmacokinetic-Pharmacodynamic Modelling of Anticancer Drugs : Haematological Toxicity and Tumour Response in Hollow Fibres." Doctoral thesis, Uppsala University, Division of Pharmacokinetics and Drug Therapy, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3370.

Full text

Abstract:

<p>Established quantitative relationships between dose, plasma concentrations and response [pharmacokinetic-pharmacodynamic (PKPD) models] have a high potential in improving therapeutic indices of anticancer drug therapy and in increasing drug development efficiency. PKPD modelling is a helpful tool for characterising and understanding schedule dependence. The aim of this thesis was to develop PKPD models of anticancer drugs for tumour effects and haematological toxicity, which is the most frequent dose-limiting toxicity.</p><p>PK and haematological toxicity after several schedules were studie

APA, Harvard, Vancouver, ISO, and other styles

50

Mollel, Happiness. "Development and assessment of azithromycin paediatric suppository formulations." Thesis, Rhodes University, 2006. http://eprints.ru.ac.za/1345/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!