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Books on the topic 'Pharmacological Investigation'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Rauf, Abdur, Hafiz Ansar Rasul Suleria, and Syed Muhammad Mukarram Shah. Phytochemical and Pharmacological Investigation of the Family Rutaceae. Apple Academic Press, 2024. http://dx.doi.org/10.1201/9781003401469.

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2

Nichols, Eve K. Expanding access to investigational therapies for HIV infection and AIDS: March 12-13, 1990, conference summary. National Academy Press, 1991.

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3

Feng, Wang, ed. Biomarker methods in drug discovery and development. Humana Press, 2008.

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4

Psycho-Pharmacological Investigation of Herbal Extracts Using Animal Models. Independently Published, 2020.

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5

Pereira, Jennifer A. Are brand-name and generic warfarin interchangeable?: A pharmacological and behavioural investigation. 2003.

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6

Bairagi, Shriram, Jayshri Bairagi, and Manohar Patil. Investigation on Wood of Sesbania Sesban merr, Fabaceae: Pharmacognostic, Phytochemical and Pharmacological Investigation on Wood of Sesbania Sesban merr, Fabaceae. VDM Verlag Dr. Müller, 2011.

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7

Brenner, Lynne Anne. Pharmacological investigation of cholecystokinin (CCK) receptors involved in suppression of food intake by intestinal nutrients. 1995.

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8

Mikaili, Peyman, and Ali Asghar Hemmati. New Pharmacological Trends in Therapy of Pulmonary Fibrosis: Investigation of the involving phenomena in the process of bleomycin-induced fibrosis. LAP Lambert Academic Publishing, 2012.

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9

Dash, Pritesh Ranjan. Phytochemical Screening and Pharmacological Investigations on Hedychium Coronarium. Anchor Academic Publishing. ein Imprint der Diplomica Verlag GmbH, 2016.

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10

Steinbrecher, Henrik. Urinary incontinence and bladder dysfunction. Edited by David F. M. Thomas. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199659579.003.0119.

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Urinary incontinence is one of the commonest problems encountered in paediatric practice. Recent advances in our understanding of the causes, coupled with the introduction of newer pharmacological agents have expanded the treatment options. This chapter summarizes the terminology and classification of urinary incontinence and describes the development of normal bladder control and the causes of urinary incontinence and bladder dysfunction in children. Although most children experience a favourable long-term outcome, a small minority will require urological intervention for intractable incontin

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11

Stewart, S. Evelyn, and Clare Bleakley. Treatment of Pediatric OCD. Edited by Christopher Pittenger. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190228163.003.0042.

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Appropriate OCD treatment has the potential to reverse negative impacts on the developmental trajectory of youth with this disease. First-line treatments for pediatric OCD have been well established, including cognitive behavior therapy (CBT), serotonin reuptake inhibitors (SRI), and the combination thereof. However, a significant proportion of OCD-affected youth do not achieve response or remission following initial treatment, and access to OCD-focused CBT treatment is often limited. Knowledge of CBT and SRI response predictors, mechanisms of action, and augmentation strategies for pediatric

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12

Olson, Kate, ed. Oxford Handbook of Cardiac Nursing. Oxford University Press, 2014. http://dx.doi.org/10.1093/med/9780199651344.001.0001.

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This new edition of the Oxford Handbook of Cardiac Nursing includes expanded information on prevention of cardiovascular disease and heart disease in pregnancy, as well as the latest resuscitation guidelines, protocols, and clinical information. It covers assessment, investigation, treatment, rehabilitation, and pharmacological interventions, and new illustrations and diagrams have been added throughout to aid clarity of information. Although a large part of it focuses on caring for patients with coronary heart disease, many other cardiovascular problems, such as valvular heart disease, congen

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13

Coleman, William L., and R. Michael Burger. Extracellular Single-Unit Recording and Neuropharmacological Methods. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199939800.003.0003.

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Small biogenic changes in voltage such as action potentials in neurons can be monitored using extracellular single unit recording techniques. This technique allows for investigation of neuronal electrical activity in a manner that is not disruptive to the cell membrane, and individual neurons can be recorded from for extended periods of time. This chapter discusses the basic requirements for an extracellular recording setup, including different types of electrodes, apparatus for controlling electrode position and placement, recording equipment, signal output, data analysis, and the histologica

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14

Dittrich, Kurt F. Headache. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190217518.003.0022.

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Having a solid grasp of headaches is essential for the pain provider. This required knowledge should include understanding the anatomy and physiology of headaches; knowing how to classify headaches using the second edition of the International Classification of Headache Disorders; recognizing the physical, psychological, and social factors that may contribute to headaches; and understanding the role of counseling and nonpharmacological treatment options. It is essential to understand the pharmacological aspects of headache management as well as some of the nuances of the specific medications m

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15

Kass, Erica, Jonathan E. Posner, and Laurence L. Greenhill. Pharmacological Treatments for Attention-Deficit/Hyperactivity Disorder and Disruptive Behavior Disorders. Oxford University Press, 2015. http://dx.doi.org/10.1093/med:psych/9780199342211.003.0004.

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More than 225 placebo-controlled type 1 investigations demonstrate that psychostimulants are highly effective in reducing core symptoms of attention-deficit/hyperactivity disorder (ADHD) in children and adults. In contrast, there are limited type I studies demonstrating that psychopharmacological management with U.S. Food & Drug Administration-approved agents for ADHD (stimulants and nonstimulants), atypical antipsychotics, and mood stabilizers decrease the defiant and aggressive behavior characteristic of disruptive behavior disorders. Stimulant treatment evidence has been supplemented by

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16

Chowdhury, Aszadur Rahman, K. M. Shams-Ud-Doha, and Kh Tanvir Ahmed. Phytochemical and Biological Investigations of Thunbergia grandiflora: Characterization of phytochemical compounds and pharmacological activities of Thunbergia grandiflora. LAP LAMBERT Academic Publishing, 2012.

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17

Shirali, Anushree, and Mark A. Perazella. Drug-induced nephropathies. Edited by William G. Bennett. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0362.

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Pharmacological therapy with prescription medications and other drugs is the mainstay of modern medical practice. In addition, an increasing number of people use over-the-counter and complementary treatments for management of acute and chronic disease. The kidney faces constant exposure to some of these medications and drugs since it receives significant blood flow from the systemic circulation and importantly participates in excretion of many of these substances. Some of these agents have the innate potential for nephrotoxicity, which is modified by patient- as well as drug-related factors. A

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18

Reffelmann, Thorsten, and Robert Kloner. Adjunctive Reperfusion Therapy Post-AMI. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780199544769.003.0009.

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• Reperfusion of the occluded coronary artery in an ST-segment-elevation myocardial infarction is the most effective approach for reducing infarct size, preserving left ventricular ejection fraction, lowering the incidence and severity of congestive heart failure and improving prognosis• Hence, several pharmacologic agents intended to improve target vessel patency as an adjunct to thrombolysis or primary percutaneous coronary intervention have been shown to be beneficial in patients with reperfusion therapy for acute myocardial infarction, namely antiplatelet and anticoagulation agents• Animal

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19

Yennurajalingam, Sriram, and Eduardo Bruera. Fatigue and asthenia. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199656097.003.0081.

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Fatigue is the most frequent, complex, multidimensional, and debilitating symptom in patients with advanced medical conditions. In the majority of palliative care patients, the aetiology of fatigue is multifactorial and the most common factors associated with fatigue include anorexia/cachexia, anxiety, depression, shortness of breath, sleep disturbances, anaemia, and inflammation. Routine screening for fatigue is essential for optimal assessment of fatigue and history and investigations should always be individualized. Management should initially aim towards identification and treatment of the

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20

Medforth, Janet, Linda Ball, Angela Walker, Sue Battersby, and Sarah Stables. Medical conditions during pregnancy. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198754787.003.0010.

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This chapter comprises a review of common medical conditions, including asthma, thyroid conditions, cardiac conditions, and renal diseases. There is a small section on renal transplant and care of the woman during pregnancy. Insulin-dependent diabetes, non-insulin-dependent diabetes, gestational diabetes, and their impact on pregnancy are discussed. The effect of pregnancy on the conditions themselves is reviewed, along with recognition and management of pregnancy changes due to the condition. Pregnancy management options, including altered physiology and pharmacological treatment, are discuss

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21

Kittel-Schneider, Sarah. The treatment of bipolar mixed states. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198748625.003.0005.

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Definition of mixed episodes has changed in the Diagnostic and Statistical Manual of Mental Disorders (5th edition) (DSM-5). A mixed feature specifier can be added not only to major depressive episodes and manic episodes in bipolar patients but also to hypomanic episodes in bipolar II patients and major depressive episode in major depressive disorder. Atypical antipsychotics seem to be effective in acute treatment as well as valproate and carbamazepine. Regarding prophylaxis of mixed states, monotherapy with valproate, olanzapine and quetiapine seems to prevent mixed episodes. Adjunctive thera

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22

Segraves, R. Taylor. Pharmacotherapy and Psychotherapy for Sexual Dysfunctions. Oxford University Press, 2015. http://dx.doi.org/10.1093/med:psych/9780199342211.003.0022.

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Well-controlled, double-blind, multisite investigations have demonstrated the efficacy of phosphodiesterase type 5 inhibitors for the treatment of erectile problems of mixed etiologies. A large number of studies affirm that serotonergic antidepressants delay ejaculation in men with premature ejaculation. Similarly, studies have demonstrated the efficacy of transdermal testosterone therapy in restoring sexual function in women after oophorectomy. There is suggestive evidence of the efficacy of cognitive-behavioral therapy in the treatment of sexual dysfunction in both sexes. However, the number

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23

Welch, Killian A. Alcohol Abuse. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199937837.003.0185.

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Unqualified, “alcohol” refers to ethyl alcohol (C2H5OH), the favored drug of much of the world’s population. It was probably discovered following experimental fermentation, and archaeological investigations suggest that beer was being habitually consumed earlier than 6000 BCE. Although often considered a “moral failing,” the neurobiological changes that underpin addiction to alcohol are increasingly understood. This has been accompanied by development of an increasing variety of interventions for alcoholism with demonstrated efficacy, these spanning the social, psychological, and pharmacologic

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24

Poroikov, Vladimir, and Roman Efremov, eds. PROCEEDINGS BOOK OF THE XXVIII SYMPOSIUM "BIOINFORMATICS AND COMPUTER-AIDED DRUG DISCOVERY", MOSCOW, 2022. Institute of Biomedical Chemistry, Moscow, Russia, 2022. http://dx.doi.org/10.18097/bcadd2022.

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The materials of the XXVIII Symposium "Bioinformatics and Computer-Aided Drug Discovery" are presented. This Symposium is dedicated to the emerging challenges and opportunities for in silico drug discovery.The Symposium's main topics: development and practical application of computational methods for finding and validation of new pharmacological targets, in silico design of potent and safe pharmaceutical agents, optimization of the structure and properties of drug-like compounds, rational approaches to the utilization of pharmacotherapeutic remedies in medical practice. This information will b

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25

Hammond, Alexis S., and Eric C. Strain. Current Approved Pharmacotherapies for Substance Use Disorders. Edited by Dennis S. Charney, Eric J. Nestler, Pamela Sklar, and Joseph D. Buxbaum. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190681425.003.0049.

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About 3%–6% of the US population (an estimated 17 million people) were diagnosed with a substance use disorder (SUD) in 2014. This significant problem requires continued development of appropriate and effective therapies. Current treatments often include a combination of both pharmacologic and psychosocial modalities, tailored to an individual’s needs. This chapter provides a general overview of the pharmacotherapies that are currently approved by the US Food and Drug Administration for particular SUD indications. Those SUDs for which there are approved treatments include opioids, nicotine, an

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26

Anthony, James, David A. Barondess, Mirjana Radovanovic, and Catalina Lopez-Quintero. Polydrug Use. Edited by Kenneth J. Sher. Oxford University Press, 2014. http://dx.doi.org/10.1093/oxfordhb/9780199381708.013.006.

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This chapter reviews selected research topics and issues in relation to research on polydrug use. It includes a review of the history of the concept of polydrug use and often-referenced terminological confusion in this area of public health research. A pharmacoepidemiological perspective on responses to drug compounds taken in combination is presented, with coverage of sometimes misunderstood concepts such as interaction, antagonism, and synergy. The distinction is made between a description of subgroup variation in responses to a drug and drug–drug interactions for which there is an underlyin

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27

Wong, Stacy N., and Line G. Jacques. Neuropathic Groin Pain. Edited by Meghan E. Lark, Nasa Fujihara, and Kevin C. Chung. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190617127.003.0017.

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Chronic neuropathic groin pain may be iatrogenic or posttraumatic and can be disabling or even crippling in some individuals. Patients may have significant sleep disturbances and may experience psychosocial effects along with significant physical limitations. A combination of pharmacologic treatments with physical therapy and local infiltrations may be useful. Neurostimulation techniques, including spinal cord stimulation, peripheral nerve stimulation, and dorsal root ganglion stimulation, have shown promising results in the treatment of chronic neuropathic pain. In certain cases, surgical app

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28

Poroikov, V. P., and R. G. Efremov, eds. PROCEEDINGS BOOK OF THE XXIX SYMPOSIUM “BIOINFORMATICS AND COMPUTER-AIDED DRUG DISCOVERY”. Institute of Biomedical Chemistry, Moscow, Russia, 2023. http://dx.doi.org/10.18097/bcadd2023.

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The materials of the XXIX International Symposium “Bioinformatics and Computer-Aided Drug Discovery” (Virtual, 18-20 September 2023) are presented. This Symposium is dedicated to the emerging challenges and opportunities for in silicodrug discovery. Contemporary fields of biomedical science devoted to the analysis of normal and pathological states of the organism and revealing the pathological processes at the cellular and molecular levels are discussed. The main topics include: development and practical application of computational methods for finding and validation of new pharmacological tar

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29

Glannon, Walter. Psychiatric Neuroethics I. Edited by John Z. Sadler, K. W. M. Fulford, and Werdie (C W. ). van Staden. Oxford University Press, 2014. http://dx.doi.org/10.1093/oxfordhb/9780198732372.013.30.

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Severe psychiatric disorders may be resistant to conventional pharmacological and psychotherapeutic treatments. Invasive interventions such as deep-brain stimulation (DBS) and neurosurgical ablation (lesioning) can modulate dysfunctional neural circuits implicated in these disorders. Yet these two forms of psychiatric neurosurgery are still experimental and investigational and thus their safety and efficacy have yet to be established. This chapter is an examination and discussion of the main ethical issues surrounding the experimental use of DBS and lesioning for treatment-refractory psychiatr

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30

Friedman, Deborah I., Shamin Masrour, and Susan Hutchinson. Headache. Edited by Emma Ciafaloni, Cheryl Bushnell, and Loralei L. Thornburg. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190667351.003.0012.

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In most cases, women with headache disorders have normal pregnancy and delivery outcomes and should not be discouraged from becoming pregnant. Pre-pregnancy planning includes weaning of contraindicated medications. Most women with migraine without aura improve during pregnancy. Although there are limitations, various acute and preventive treatments may be employed, including non-pharmacologic options. Anti-epileptic medications should be avoided. For pseudotumor cerebri, the mainstay of treatment includes diuretics and therapeutic lumbar punctures, avoiding topiramate. Surgical treatment may b

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31

Voeten, Teun. Devil's Drug. Rowman & Littlefield Publishers, 2025. https://doi.org/10.5040/9798881847463.

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With a combination of thorough investigative journalism, daring fieldwork, and colorful atmospheric sketches, Teun Voeten draws a very detailed and disturbing picture of a drug that is on a rapid international rise. Methamphetamine, commonly referred to as crystal meth, is one of the most addictive drugs in the world. Heavy users can destroy themselves in just a few months. Originally given by the Nazis to their troops to fight the blitzkrieg, it has now conquered the whole world and is used at sex parties in Amsterdam and Antwerp, by former hippies in Prague, by the underclass in the slums of

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32

Hoff, Scott, and Nancy A. Collop. Sleep Disorders and Recovery from Critical Illness. Oxford University Press, 2014. http://dx.doi.org/10.1093/med/9780199653461.003.0022.

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Many factors contribute to sleep disruption in critically ill patients. Sleep is a complex process, with broad effects on diverse physiologic systems. Environmental factors, such as light exposure, noise from diverse sources, and sleep interruptions related to patient care, have all received considerable investigational attention. Critical illness can affect elements involved in sleep initiation and maintenance. The various modes of mechanical ventilation may have different effects on sleep fragmentation and on the propensity to cause central apnoeas, thereby potentially prolonging the time on

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33

Medicine, Institute of, and Roundtable for the Development of Drugs and Vaccines Against AIDS. Expanding Access to Investigational Therapies for HIV Infection and AIDS. National Academies Press, 1991.

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34

Expanding Access to Investigational Therapies for HIV Infection and AIDS. National Academies Press, 1991.

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35

Analgesia Methods And Protocols. Humana Press, 2010.

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36

Analysis of quantal response data. Chapman & Hall, 1992.

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37

Biologically-Responsive Hybrid Biomaterials: A Reference for Material Scientists and Bioengineers. World Scientific Publishing Co Pte Ltd, 2010.

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38

Chemical Toxicity Prediction: Category Formation and Read-Across. Royal Society of Chemistry, The, 2013.

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39

Chemical Toxicity Prediction: Category Formation and Read-Across. Royal Society of Chemistry, The, 2013.

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40

Biologically-responsive hybrid biomaterials: A reference for material scientists and bioengineers. World Scientific, 2010.

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41

Queer science: The use and abuse of research into homosexuality. MIT Press, 1996.

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