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Relevant bibliographies by topics / Pharmacological Investigation / Dissertations / Theses

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Dissertations / Theses on the topic 'Pharmacological Investigation'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Habtemariam, Solomon. "Phytochemical and pharmacological investigation of some medicinal plants." Thesis, University of Strathclyde, 1992. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=21299.

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This thesis describes phytochemical and biological/pharmacological studies on six medicinal plants. Plant materials were extracted by ethanol, tested for their biological activity and then subjected to "bioassay-guided fractionation" to yield active and inactive compounds. The compounds were identified by standard physico-chemical techniques including UV, IR, NMR and ElMS. The crude ethanol extract of the leaves of Premna shcimperi was found to be antibacterial against gram positive bacteria (Staphylococcus aureus and Bacillus subtilis). An antibacterial bioassay-guided fractionation of the ex

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2

Hu, Fuliang. "An investigation into the pharmacological properties of propolis." Thesis, Rhodes University, 2005. http://hdl.handle.net/10962/d1007955.

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Propolis is a traditional value-added product from beekeeping, and has been widely used in medicine and the chemical industry because of its extensive biological activities. In this dissertation some pharmacological properties of propolis extracted by ethanol (EEP) and water (WSP) were studied by means of modem pharmacological methods. The results of the experiments show the following: 1. Both EEP and WSD led to decreased levels of fasting blood glucose (FBG), glycosylated haemoglobin (HBA1c), Fructosamine (FRU), blood urea nitrogen (BUN), uric acid (UA), malonaldehyde (MDA), nitric oxide (NO)

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3

Guité, Pierre. "Pharmacological investigation on the composite nature of the electroretinogram." Thesis, McGill University, 1991. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=59947.

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This research project deals with the electroretinogram (ERG) and the role played by the oscillatory potentials (OPs) in its generation. Investigators are still debating over the cellular origin of these fast components but the current view is that the OPs are produced by structures different from those involved in the genesis of the b-wave (positive wave of the ERG). Another claim would be that the OPs should be considered the primary electrical events produced by the retina and their summation would yield the b-wave. A pharmacological approach was chosen to investigate the OP-b-wave relations

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4

Mao, Kangyi. "Microstructural investigation of tablet compaction and tablet pharmacological properties." Thesis, Massachusetts Institute of Technology, 2010. http://hdl.handle.net/1721.1/62108.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 2010.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>In current tablet manufacturing processes, there is a knowledge gap concerning material transformation and the subsequent impact on tablet properties; this gap presents a barrier to rational formulation / process design. In this study, it was hypothesized that the understanding of tablet microstructure is pivotal in bridging our knowledge about the materials, the manufacturing process, and the tablet properties. A serie

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5

Nyamwaro, Helenne M. "Pharmacological investigation of porcine bladder function and sensory activity." Thesis, Sheffield Hallam University, 2012. http://shura.shu.ac.uk/20130/.

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Overactive bladder (OAB) is a common condition of the lower urinary tract (LUT) that is characterised by urinary urgency, with or without incontinence, accompanied by frequency and nocturia as a result of involuntary urinary bladder contractions. OAB affects millions of people worldwide and has a significant impact on quality of life. A significant amount of research has been undertaken, and is still on-going, investigating the underlying mechanisms of bladder dysfunction and the development of new therapeutic agents for the treatment of LUT conditions. It is now clear that the simplistic ideo

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6

Matera, C. "DESIGN, SYNTHESIS AND PHARMACOLOGICAL INVESTIGATION OF NOVEL BIFUNCTIONAL COMPOUNDS." Doctoral thesis, Università degli Studi di Milano, 2010. http://hdl.handle.net/2434/150203.

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Background - An increasing number of receptor interactions depends on their physical association, and receptor hetero(di)mers usually show pharmacological and functional properties different from those of their constituent partners, thus behaving as new receptor entities. In particular, striatal dopaminergic transmission appears to be under the control of receptor heteromers containing D2 autoreceptors and non-alpha7 nicotinic acetylcholine receptors (nAChRs). This evidence encouraged an in-depth investigation of the biochemical and functional interactions between dopaminergic autoreceptors an

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7

Frazer, Carol-Anne. "An investigation of the pharmacological and non-pharmacological management of postoperative nausea and vomiting induced by patient controlled analgesia." Thesis, University of Ulster, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.314034.

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8

Banjar, W. M. A. "An investigation of the pharmacological responsiveness of human eccrine sweat glands." Thesis, University of Manchester, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.378016.

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9

Hassanali, Azra. "Investigation of nitrergic relaxation in human gastrointestinal muscle using pharmacological methods." Thesis, King's College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298279.

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10

Kholghi, Abeer Othman A. "Pharmacological investigation of clinically achievable concentrations of resveratrol in colorectal cancer." Thesis, University of Leicester, 2014. http://hdl.handle.net/2381/29247.

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Resveratrol, a polyphenol present in red wine and peanuts exerts an array of beneficial effects, including anticancer activity and calorie restriction (CR) mimicry. Work from our laboratory has shown for the first time that low doses of resveratrol, comparable to amounts contained in a glass of red wine significantly reduced adenoma development in ApcMin/+ mice when given with a high fat diet. The protective effect was more pronounced than that caused by higher amounts, equivalent to doses used in clinical trials. The CR activity of resveratrol is mediated via the energy regulator AMP-activate

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11

Hou, Ruihua. "Pharmacological investigation of the regulation of autonomic functions and arousal in humans." Thesis, University of Nottingham, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.438275.

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12

Porter, Richard Hugh Phillip. "An investigation of NMDA and metabotropic glutamate receptors and their pharmacological regulation." Thesis, University of Southampton, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.387118.

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13

McFerren, Marcus Anthony. "Traditional plant-based fishing in the Americas an ethnobotanical, phytochemical, and pharmacological investigation /." online access from Digital Dissertation Consortium access full-text, 2000. http://libweb.cityu.edu.hk/cgi-bin/er/db/ddcdiss.pl?9978142.

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14

Hiroi, Noboru 1961. "A pharmacological and neuroanatomical investigation of the conditioned place preference produced by amphetamine /." Thesis, McGill University, 1991. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=74669.

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The present study investigated the neural mechanisms by which environmental stimuli guide conditioned behaviors in the amphetamine conditioned place preference (CPP) paradigm. Systemically injected D1 and D2 dopamine antagonists blocked both acquisition and expression of the CPP: the selective D1 antagonist more effectively blocked expression than the D2 antagonists. The site of action of the antagonists on expression was the nucleus accumbens. Systemically injected reserpine, but not intra-accumbens a-MPT microinjections, also blocked the expression of the amphetamine CPP. Pre-conditioning an

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15

Brain, John George. "Investigation of injury and pharmacological modulation of biliary epithelial cells in ductopenic disease." Thesis, University of Newcastle upon Tyne, 2014. http://hdl.handle.net/10443/2437.

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Senescence and its associated secretory phenotype have been investigated in several vanishing bile duct syndromes. The current study evaluated the presence of senescent biliary epithelial cells (BEC) in acute cellular rejection of human liver allografts to ascertain whether senescent cells contribute to human disease progression in liver transplantation. There was a significant correlation between senescent BEC and grade of rejection. Furthermore there was a significant correlation between grade of rejection and BEC undergoing epithelial to mesenchymal transition (EMT). There was never any ove

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16

Sekar, Sakthivel. "Investigation of Neuronal Effects of Anxiogenic and Antidepressant Medications using Pharmacological Magnetic Resonance Imaging." Thesis, University of Newcastle Upon Tyne, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.519474.

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17

Stanley, Christopher Peter. "An investigation into the pharmacological effects of phytocannabinoids and endocannabinoids in human mesenteric arteries." Thesis, University of Nottingham, 2013. http://eprints.nottingham.ac.uk/28848/.

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Cannabinoids cause both acute and time-dependent vasodilation/vasorelaxation in a range of vascular beds. The vascular effect of cannabinoids is dependent on the cannabinoid ligand, the species studied and the vascular bed used. To date, there have been four studies that have characterised the effects of cannabinoids in humans. Therefore, the aim of this thesis was to characterise the pharmacological effects of cannabinoids in the human mesenteric artery. Written Informed consent was granted for the use of mesenteric arteries collected from patients at the Royal Derby Hospital. Arteries were d

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18

Bitsios, Panagiotis. "A psychophysiological and pharmacological investigation of the autonomic regulation of the pupil in man." Thesis, University of Nottingham, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.337277.

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19

Mutter, F. E. M. "Investigation of Nrf2 activity measures for assessing the toxicological and pharmacological effects of drugs." Thesis, University of Liverpool, 2018. http://livrepository.liverpool.ac.uk/3022492/.

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20

Chandrasekar, Akila [Verfasser]. "Inhibition shapes vulnerability to traumatic brain Injury : pharmacological, toxicological and chemogenetic investigation / Akila Chandrasekar." Ulm : Universität Ulm, 2020. http://d-nb.info/1212115260/34.

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21

Yamamoto, Noriyuki. "Development of a selective inhibitor for Syk tyrosine kinase and investigation of its pharmacological activities." 京都大学 (Kyoto University), 2003. http://hdl.handle.net/2433/148369.

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22

Cross, Helen Fiona. "A molecular and pharmacological investigation of the action of ivermectin against Onchocerca ochengi of cattle." Thesis, University of Liverpool, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266171.

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23

MacPherson, Tom. "Genetic and pharmacological investigation of α4-containing GABAA receptors in conditioned behaviours influenced by cocaine". Thesis, University of Sussex, 2014. http://sro.sussex.ac.uk/id/eprint/47585/.

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α4-subunit containing GABAA receptors (α4-GABAARs) are often found co-assembled with δ-subunits in extrasynaptic locations on nucleus accumbens (NAc) medium spiny neurons (MSNs), were they mediate a tonic form of inhibition thought to control the excitability of the neuron. This thesis combines genetic and pharmacological techniques to explore the role of α4-GABAARs in locomotor and reward-conditioned behaviours. Activation of α4-GABAARs by systemic or intra-accumbal administration of THIP, a GABAAR agonist with a preference for δ-subunits, was able to reduce cocainepotentiated locomotor activ

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24

Slade, Rozanna Louise. "Investigation of positron emission tomography for pharmacological assessment of epidermal growth factor receptor-directed therapies." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/18660.

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The epidermal growth factor receptor (EGFR) is overexpressed in many cancers including lung, breast, head and neck and brain. Furthermore, mutations of this receptor have been shown to play crucial roles in response to EGFR-targeted therapies in non small cell lung carcinoma (NSCLC) patients. Imaging EGFR or its function using positron emission tomography (PET) could aid in selection and monitoring patient’s therapeutic response to small molecule tyrosine kinase inhibitors (TKIs) including gefitinib. The aims of this project are first to further investigate the use of a series of cyanoquinolin

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25

Le, Page Lydia Marie. "Investigation of pharmacological and physiological regulation of pyruvate dehydrogenase in diabetes using hyperpolarised magnetic resonance spectroscopy." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:268112cc-0188-4224-99b4-b69904352b41.

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In type II diabetes, systemic metabolism is perturbed and on a cellular level the balance of fuel use is upset. More specifically, increased fatty acid use is seen alongside decreased glucose metabolism. This altered fuel use is mediated by changes in the activity and expression of multiple enzymes. One such enzyme within the glucose breakdown pathway is pyruvate dehydrogenase, whose activity is known to be reduced in the diabetic state. The field of real-time metabolic investigation has rapidly expanded over the past few years due to the invention of technology that has enabled the production

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26

van, Waes Linda T. A., and University of Lethbridge Faculty of Arts and Science. "Does one plus one make two? Investigation of pharmacological effects and cortical injury on the developing brain." Thesis, Lethbridge, Alta. : University of Lethbridge, Deptartment of Neuroscience, 2008, 2009. http://hdl.handle.net/10133/782.

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This thesis examined how pharmacological treatment and cortical injury during development affects brain plasticity. Rats were given either a low dose of perinatal fluoxetine or a mild postnatal day 7 Hypoxic‐Ischemic (HI) injury, both, or neither. The functional outcome was assessed using a series of behavioral tasks and anatomical measures. To assess how HI affects the development of motor maps, forelimb motor maps were evoked at P19. The findings indicate that fluoxetine treatment or HI injury mostly negatively affected functional outcome. The combined treatment with fluoxetine and HI injury

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27

Guest, Marcus. "An investigation into the mode of action of the anthelmintic emodepside : a molecular, pharmacological and electrophysiological characterisation." Thesis, University of Southampton, 2008. https://eprints.soton.ac.uk/66714/.

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Resistance to anthelmintics is increasingly becoming a problem for the agricultural industry. Emodepside is a novel anthelmintic that is effective against a variety of parasitic nematodes in which resistance to other anthelmintics has developed (Harder and Samson-Himmelstjerna, 2002). This suggests that emodepside has a novel mode of action. The aim of this study was to further investigate the mechanism of action of emodepside using the model organism Caenorhabditis elegans. The latrophilin receptors have previously been implicated in the mechanism of action of emodepside. The natural compound

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28

Velia, M. І. "Investigation of the pharmacological action of Tanacetum parthenium in order to develop a drug based on it." Thesis, БДМУ, 2020. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/18253.

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29

Lockwood, S. M. "An investigation of the pharmacological modulation of diffuse noxious inhibitory controls in a monoiodoacetate model of osteoarthritis." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10050016/.

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Osteoarthritis (OA) is a disabling disease of the synovial joints. Structurally, OA involves the degenerative breakdown of articular cartilage, inflammation of the synovium and sclerosis of the subchondral bone, which ultimately results in a loss of function and integrity of the synovial joints. Clinically, it is the chronic pain associated with OA that causes patients to seek medical attention. Traditional analgesics used to relieve the chronic pain associated with OA aim to alleviate peripheral nociception at the level of the diseased joint. However, OA patients often develop referred pain a

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30

Lau, Clara Bik-San. "A phytochemical and pharmacological investigation of Momordica charantia Linn. fruit with respect to its reputed anti-diabetic properties." Thesis, King's College London (University of London), 1998. https://kclpure.kcl.ac.uk/portal/en/theses/a-phytochemical-and-pharmacological-investigation-of-momordica-charantia-linn-fruit-with-respect-to-its-reputed-antidiabetic-properties(629171e9-f30c-44d4-8c53-101eba0b8fe0).html.

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Plants have been used traditionally for the treatment of diabetes mellitus all over the world. One such example is the bitter-tasting unripe fruit of Momordica charantia Linn. (Cucurbitaceae), commonly known as karela. Numerous studies in humans, animals and in vitro models have demonstrated a potential beneficial effect of karela juice or extracts in diabetes. However, the mode of action and active components of karela have not been satisfactorily explained. The present study aimed to use a systematic, relevant approach (bioassay-guided fractionation) to isolate and identify orally active ant

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31

Pétursson, Pétur. "Why Non-Pharmacological Prescribing of Antibiotics? : A Phenomenological Investigation into the Rationale behind it from the GP’s perspective." Thesis, Nordic School of Public Health NHV, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:norden:org:diva-3275.

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BACKGROUND: Concern has increased worldwide with regard to the over-prescribing of antibiotics, as well as the fact that more bacteria strains are developing resistance to antibiotics. According to research, a great deal of this use is for what has been called “non-pharmacological” reasons. The reduction of unnecessary antibiotic use and exploration of the reasons for ”irrational prescribing” has become a public health priority. OBJECTIVE: To study the reasons cited by Icelandic general practitioners for their “non-pharmacological” prescribing of antibiotics. DESIGN: A qualitative interview-st

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32

Kariyawasam, Sandhya Himani. "An investigation into the biochemical changes in Tourette syndrome and associated conditions with a potential for pharmacological manipulation." Thesis, Aston University, 1999. http://publications.aston.ac.uk/10977/.

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Kynurenine (KYN) is the first stable metabolite of the kynurenine pathway, which accounts for over 95% of tryptophan metabolism. Two previous studies by this research group reported elevated plasma KYN in Tourette syndrome (TS) patients when compared with age and sex matched controls and another study showed that KYN potentiated 5-HT2A-mediated head-shakes (HS) in rodents. These movements have been suggested to model tics in TS. This raised the questions how KYN acts in eliciting this response and whether it is an action of its own or of a further metabolite along the kynurenine pathway. In th

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33

Schmidt, Karl F. "Development of Pharmacological Magnetic Resonance Imaging Methods and their Application to the Investigation of Antipsychotic Drugs: a Dissertation." eScholarship@UMMS, 2006. https://escholarship.umassmed.edu/gsbs_diss/114.

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Pharmacological magnetic resonance imaging (phMRI) is the use of functional MRI techniques to elucidate the effects that psychotropic drugs have on neural activity within the brain; it is an emerging field of research that holds great potential for the investigation of drugs that act on the central nervous system by revealing the changes in neural activity that mediate observable changes in behavior, cognition, and perception. However, the realization of this potential is hampered by several unanswered questions: Are the MRI measurements reliable surrogates of changing neural activity in the p

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34

Haythorne, Elizabeth. "Investigation of KATP channel function in response to metabolic and pharmacological manipulation, in the hypothalamic GT1-7 cell line." Thesis, University of Dundee, 2014. https://discovery.dundee.ac.uk/en/studentTheses/419b0b9f-3596-4724-a4b4-01254bfcc44c.

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Animal and human studies have consistently demonstrated that recurrent hypoglycaemia (RH) blunts both hormonal and behavioral counter regulatory responses (CRR) to further episodes of hypoglycaemia. It is now well established that the brain is involved in regulating whole-body glucose homeostasis, including the CRR to hypoglycaemia. The aim of the current study was to investigate if adaptations occur, following RH, which are intrinsic to glucose-sensing neurons in the absence of synaptic/glial inputs or signals from the periphery. Utilising the GT1-7 hypothalamic mouse cell line as an in vitro

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35

Hicks, Blánaid. "Modifiable risk factors and cancer survival : an investigation of pharmacological exposures, smoking and survival among breast and colorectal cancer patients." Thesis, Queen's University Belfast, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.695367.

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The aim of this thesis was to examine modifiable risk factors that may influence cancer survival in colorectal and breast cancer patients, focusing on investigations of pharmacological exposures as well as smoking. While there is extensive evidence of the effects of smoking on cancer incidence, less is known of the effects of continued smoking after a cancer diagnosis on survival. A systematic review and meta-analysis conducted as part of this thesis, identified 20 studies that assessed the impact of smoking on colorectal cancer survival. Overall, this study found that smoking after a colorect

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36

Hill, Michael R. H. "New research tools for in vitro voltage sensitive dye imaging and their application in a pharmacological investigation of the barrel cortex." Thesis, University of Oxford, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.526516.

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37

Wolmarans, Petrus De Wet. "Stereotypical behaviour in the deer mouse (Peromyscus Maniculatus bairdii) : a pharmacological investigation of the frontal–cortico–striatal serotonergic system / Wolmarans D." Thesis, North-West University, 2011. http://hdl.handle.net/10394/7585.

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Obsessive–compulsive disorder (OCD) is a psychiatric condition that is characterized by two main symptom cohorts, namely recurrent inappropriate thoughts (obsessions) and seemingly purposeless repetitive motor actions (compulsions). In 70% of cases, the condition only re–sponds to chronic, but not sub–chronic, high dose treatment with the selective serotonin reup–take inhibitors (SSRIs), such as fluoxetine and escitalopram. This indicates a role for hyposero–tonergic functioning in the primary brain areas involved in OCD, namely the components of the cortico–striatal–thalamic–cortical (CSTC) c

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38

Douthwaite, Julie Ann. "Endothelin and chronic renal failure : a biochemical and pharmacological investigation of a blood pressure-independent role of endothelin-1 in renal fibrosis." Thesis, University of Sheffield, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312808.

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39

MOLLA, DAVID. "INVESTIGATION ON PHARMACOLOGICAL AND AGE-INDUCED MODULATIONS OF CARDIAC PEACEMAKING AND ELECTROPHYSIOLOGICAL CHARACTERIZATION OF A COMPOUND MUTATION IN THE CARDIAC SODIUM CHANNEL." Doctoral thesis, Università degli Studi di Milano, 2021. http://hdl.handle.net/2434/816791.

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Abstract: During my Ph.D. internship at the ‘PaceLab’, I have been involved in several scientific projects that, although involving different experimental models and with different aims, share the common background of cardiac pacemaker modulation and ion channels activity. In this sec-tion are briefly described the three main research lines in which I took part; a more complete discussion of the data will be presented later in this thesis. Notably, by the time I am writing this proposition, two of these studies have been submitted to scientific journals. - Identification of the bradyc

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Duran, M. Ortega. "Investigation of mechanisms of drug resistance in colorectal cancer : a proteomic and pharmacological study using newly developed drug-resistant human cell line subclones." Thesis, University of Bradford, 2017. http://hdl.handle.net/10454/15064.

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Despite therapeutic advances, colorectal cancer still has a 45% mortality rate, and one of the most crucial problems is the development of acquired resistance to treatment with anticancer drugs. Thus the aims of this project are to develop drug-resistant colon cancer cell lines in order to identify mechanisms of resistance for the most commonly drugs used in colorectal cancer: 5-fluorouracil, oxaliplatin, and irinotecan. Following evaluation of drug sensitivity to these agents in an initial panel of eight colorectal cancer cell lines, 3 lines (DLD-1, KM-12 and HT-29) were selected for the deve

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41

Zraikat, Manar Saleh Ali. "Development of in vitro models of invasion for the pharmacological investigation of small molecule inhibitors of tumour progression : development and validation of a 3-dimensional tumour spheroid invasion model to evaluate the pharmacological effects of novel small molecule β3 integrin antagonists". Thesis, University of Bradford, 2015. http://hdl.handle.net/10454/7511.

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Tumour dissemination is a major reason for failure of therapy for many tumour types therefore there is a requirement for novel targets & therapies. The αIIbβ3 and αvβ3 integrins have been demonstrated to have significant involvement at many stages of the tumour dissemination process including, tumour cell adhesion, migration, metastasis and angiogenesis, and thus the β3 integrins are a potential target for therapeutic antagonism with small molecules. Because of the clear interaction between the different integrin types, targeting integrins as a therapeutic strategy requires targeting more than

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42

Thomas, Lea Maria [Verfasser], Oliver [Gutachter] Werz, Gerhard K. E. [Gutachter] Scriba, and Eugen [Gutachter] Proschak. "Molecular pharmacological investigation of archazolid for the intervention with inflammation and cancer / Lea Maria Thomas ; Gutachter: Oliver Werz, Gerhard K. E. Scriba, Eugen Proschak." Jena : Friedrich-Schiller-Universität Jena, 2017. http://d-nb.info/1177600269/34.

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Botha, Jan. "The development of a device for the investigation of dorsiflexion range of the ankle with a capacity to measure pathology, recovery and pharmacological benefit." Thesis, Stellenbosch : University of Stellenbosch, 2005. http://hdl.handle.net/10019.1/2086.

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Thesis (MScEng (Mechanical and Mechatronic Engineering))--University of Stellenbosch, 2005.<br>Various ways exist whereby balance abilities of the individual can be assessed. However, most of these are subjective methods. This thesis strives to demonstrate the effectiveness of a new device, the Dorsiflexometer that can be used to objectively assess one’s balance abilities. The Dorsiflexometer was constructed and mathematically modelled using appropriate simplifying assumptions. After its construction, the Dorsiflexometer was tested using two experimental set-ups to obtain raw data. Both

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44

Spinrath, Andreas [Verfasser]. "Development of pharmacological modulators for the orphan G protein-coupled receptor GPR17 and their application for the investigation of molecular signal transduction pathways / Andreas Spinrath." Bonn : Universitäts- und Landesbibliothek Bonn, 2011. http://d-nb.info/1044971738/34.

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George, Sophie A. "A pharmacological investigation of associative learning : the effect of ''anxiolytic'' -like drugs that modulate GABAa, NMDA and Group I mGIuRs on the expression of conditioned behaviours." Thesis, University of Sussex, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.444022.

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46

Hayn, Linda [Verfasser], Michael [Akademischer Betreuer] Koch, and Ursula [Akademischer Betreuer] Dicke. "Investigation of the "foreign body response" and its pharmacological regulation in chronic intracerebral cannula implantation in rats / Linda Hayn. Betreuer: Michael Koch. Gutachter: Michael Koch ; Ursula Dicke." Bremen : Staats- und Universitätsbibliothek Bremen, 2015. http://d-nb.info/1081765976/34.

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Pamplin, P. J. "Physiological and pharmacological investigations into trigeminal pain." Thesis, University of Bristol, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.381413.

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48

Delany, Caroline. "An investigation into the role of mGlu5 receptors in depotentiation in area CA1 of adult rat and mouse hippocampus and the kainate GluR5 receptor antagonist, LY382884 : pharmacological profile and use as a tool to study the functional role of kainate rece." Thesis, University of Bristol, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271848.

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49

Sand, Carsten. "Pharmacological investigations on reactive oxygen species in the cardiovascular system." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2002. http://dare.uva.nl/document/64883.

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Robertson, Stuart. "The bovine perfused eye as a model for pharmacological investigations." Thesis, University of Glasgow, 1999. http://theses.gla.ac.uk/39027/.

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Abstract:

The isolated perfused eye of many species has become a frequently used model in the study of ocular pharmacology. Due to its availability, cheapness and comfortable size for experimental use the bovine eye provides an attractive model for conducting perfusion experiments. Although initially rejected by Kishida et al. (1985), the bovine perfused eye has been proved to be a valid model for studying aqueous humour dynamics and the pharmacology of various antiglaucoma drugs, including the β-adrenoceptor antagonist, timolol, and the carbonic anhydrase inhibitor, MK-927 (Wilson et al., 1993). A gene

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