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Dissertations / Theses on the topic 'Pharmacological Investigations'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Pamplin, P. J. "Physiological and pharmacological investigations into trigeminal pain." Thesis, University of Bristol, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.381413.

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2

Sand, Carsten. "Pharmacological investigations on reactive oxygen species in the cardiovascular system." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2002. http://dare.uva.nl/document/64883.

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3

Robertson, Stuart. "The bovine perfused eye as a model for pharmacological investigations." Thesis, University of Glasgow, 1999. http://theses.gla.ac.uk/39027/.

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The isolated perfused eye of many species has become a frequently used model in the study of ocular pharmacology. Due to its availability, cheapness and comfortable size for experimental use the bovine eye provides an attractive model for conducting perfusion experiments. Although initially rejected by Kishida et al. (1985), the bovine perfused eye has been proved to be a valid model for studying aqueous humour dynamics and the pharmacology of various antiglaucoma drugs, including the β-adrenoceptor antagonist, timolol, and the carbonic anhydrase inhibitor, MK-927 (Wilson et al., 1993). A gene

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4

Youssef, Ahmed Mohamed Mohamed. "Pharmacological investigations into matrix metalloproteinase-activated anti-tumour prodrugs : in vitro metabolic and pharmacological investigations into a series of colchicine-based peptide prodrugs activated by tumour-expressed matrix metalloproteinases." Thesis, University of Bradford, 2014. http://hdl.handle.net/10454/13982.

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Matrix metalloproteinases (MMPs) play a significant role in degrading the extracellular matrix in cancer development and metastasis. Overexpression of matrix metalloproteinases in tumour tissues relative to normal tissues has been exploited as a target for peptide-based therapeutics, to improve therapeutic index of currently used agents. The stability of MMP-activated prodrugs in normal tissue or organs is a significant challenge for their success in the clinic. In an in vitro study, the stability of twenty six prodrugs was studied in mouse liver, kidney, lung and tumour homogenates using HPLC

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5

Youssef, Ahmed M. M. "Pharmacological investigations into matrix metalloproteinase-activated anti-tumour prodrugs. In vitro metabolic and pharmacological investigations into a series of colchicine-based peptide prodrugs activated by tumour-expressed matrix metalloproteinases." Thesis, University of Bradford, 2014. http://hdl.handle.net/10454/13982.

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6

Carmen, Kimberly A. del. "Pharmacological and molecular investigations of mechanisms of metamorphosis in the marine gastropod Phestilla sibogae." Thesis, University of Hawaii at Manoa, 2003. http://hdl.handle.net/10125/3052.

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Metamorphosis is the critical link between the larval and adult forms in the biphasic life cycle of many diverse metazoans. Metamorphosis in the marine gastropod Phestilla sibogae is rapid (taking less than 24 hours) and results in a change in habitat and feeding mode from larval facultative planktotrophs to benthic, carnivorous adults feeding on the coral P. compressa. During metamorphosis larvae of P. sibogae lose several structures such as the larval shell and operculum, the velum, larval kidney cells, larval retractor muscles, nephrocysts, and foot glands. In addition, morphogenic changes

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7

Sawant, Meera. "In Vitro Investigations of Antibiotic Influences on Nerve Cell Network Responses to Pharmacological Agents." Thesis, University of North Texas, 2014. https://digital.library.unt.edu/ark:/67531/metadc699991/.

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Neuronal networks, derived from mouse embryonic frontal cortex (FC) tissue grown on microelectrode arrays, were used to investigate effects of gentamicin pretreatment on pharmacological response to the L-type calcium channel blocker, verapamil. Gentamicin is a broad spectrum antibiotic used to control bacterial contamination in cell culture. The addition of gentamicin directly to medium affects the pharmacological and morphological properties of the cells in culture. A reproducible dose response curve to verapamil from untreated cultures was established and the mean EC50 was calculated to be 1

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8

Hald, Andreas. "Pharmacological testing and investigations of spinal astrogliosis in a murine bone cancer pain model /." Cph. : Copenhagen University, Faculty of Pharmaceutical Sciences, Department of Pharmacology and Pharmacotherapy, 2007. http://www.farma.ku.dk/index.php/Andreas-Hald/4975/0/.

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9

Chan, Susan L. F. "Biochemical and pharmacological investigations into the role of α2-adrenoceptors in rat islets of Langerhans". Thesis, Keele University, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.292754.

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10

Kellermann, Tracy. "A Pharmacological investigations of South Africa Lichens, Dessication-tolerant Plants and Medicinal Tree, Warburgia Salutaris." Doctoral thesis, University of Cape Town, 2010. http://hdl.handle.net/11427/3284.

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11

Elbakay, Jamal Ali Mohamed. "Synthesis and pharmacological evaluation of novel anti-tumour prodrugs : synthesis and pharmacological investigations into novel MMP-activated peptide-based prodrugs of methotrexate as potential cancer therapeutics." Thesis, University of Bradford, 2017. http://hdl.handle.net/10454/15102.

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Methotrexate (MTX) is an antimetabolite anticancer agent that is used in treatment of multiple cancers, such as acute lymphoblastic leukaemia and osteosarcoma. A lack of selective tumour toxicity is one of the major problems associated with MTX chemotherapy, especially when given at high doses, as in high dose MTX (HDMTX) therapy. MTX causes various toxicity problems including life-threatening nephrotoxicity, haematological toxicity and neurotoxicity. Overcoming this toxicity is of great importance and has been attempted in various ways, not least via the design of prodrugs. The concept of tum

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12

Elbakay, Jamal A. M. "Synthesis and pharmacological evaluation of novel anti-tumour prodrugs. Synthesis and pharmacological investigations into novel MMP-activated peptide-based prodrugs of methotrexate as potential cancer therapeutics." Thesis, University of Bradford, 2017. http://hdl.handle.net/10454/15102.

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13

Qinna, Nidal Adel. "Preclinical and pharmacological investigations of ordonafil, a novel phosphodiesterase-5 inhibitor for the treatment of erectile dysfunction." Thesis, King's College London (University of London), 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.420646.

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14

Morgan, Hannah Louise. "The construction and maintenance of a sense of ownership over one's body : behavioural, pharmacological and psychiatric investigations." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.607711.

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15

Fotoohi, Alan Kambiz. "Pharmacological and molecular investigations on the mechanisms underlying resistance of human leukaemia cells to the antimetabolites methotrexate, 6-mercaptopurine and 6-thioguanine /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-087-9/.

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16

Czeche, Sittah. "Pharmacological investigations on muscarinic and P2 receptor subtypes pharmacological charakterisation of the stereoisomers of glycopyrronium bromide and their tertiary analogues and evaluation of the isolated guinea pig and rat ileal longitudinal smooth muscle as novel P2 receptor subtype models /." [S.l.] : [s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=96439457X.

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17

Alresly, Zeyad [Verfasser], Ulrike [Akademischer Betreuer] Lindequist, Ulrike [Gutachter] Lindequist, and Ludger A. [Gutachter] Wessjohann. "Chemical and Pharmacological Investigations of Fomitopsis betulina (formerly: Piptoporus betulinus) and Calvatia gigantea / Zeyad Alresly ; Gutachter: Ulrike Lindequist, Ludger A. Wessjohann ; Betreuer: Ulrike Lindequist." Greifswald : Universität Greifswald, 2020. http://d-nb.info/1203299850/34.

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18

Alresly, Zeyad [Verfasser], Ulrike [Akademischer Betreuer] Lindequist, Ulrike Gutachter] Lindequist, and Ludger [Gutachter] [Wessjohann. "Chemical and Pharmacological Investigations of Fomitopsis betulina (formerly: Piptoporus betulinus) and Calvatia gigantea / Zeyad Alresly ; Gutachter: Ulrike Lindequist, Ludger A. Wessjohann ; Betreuer: Ulrike Lindequist." Greifswald : Universität Greifswald, 2020. http://nbn-resolving.de/urn:nbn:de:gbv:9-opus-34776.

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19

Gelzer, Anna Regina Maria. "Physiological and pharmacological investigations in the conscious beagle dog by telemetry (haemodynamic and electrocardiographic measurements) with supporting mechanistic studies (pressure-volume analysis) in the anaesthetised mini-pig /." [S.l.] : [s.n.], 1994. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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20

El-Muradi, E. M. A. "Mechanisms of relaxation in vascular smooth muscle : Comparative pharmacological investigations on vasodilation in the intact cardiovascular system and in isolated blood vessels of the rat using dilator agents with diverse mechanisms." Thesis, University of Bradford, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.234691.

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21

Seewald, Maria Sabine [Verfasser], Jens [Gutachter] Wippermann, and Gábor [Gutachter] Szabó. "Investigations of pharmacological pre- and posttreatments with Omegaven and ATP in a four-chamber isolated working swine heart model : implications for cardiac interventions, cardiac transplantation and ex vivo perfusion systems / Maria Sabine Seewald ; Gutachter: Jens Wippermann, Gábor Szabó." Magdeburg : Universitätsbibliothek Otto-von-Guericke-Universität, 2020. http://d-nb.info/1228071594/34.

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22

Habtemariam, Solomon. "Phytochemical and pharmacological investigation of some medicinal plants." Thesis, University of Strathclyde, 1992. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=21299.

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This thesis describes phytochemical and biological/pharmacological studies on six medicinal plants. Plant materials were extracted by ethanol, tested for their biological activity and then subjected to "bioassay-guided fractionation" to yield active and inactive compounds. The compounds were identified by standard physico-chemical techniques including UV, IR, NMR and ElMS. The crude ethanol extract of the leaves of Premna shcimperi was found to be antibacterial against gram positive bacteria (Staphylococcus aureus and Bacillus subtilis). An antibacterial bioassay-guided fractionation of the ex

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23

Hu, Fuliang. "An investigation into the pharmacological properties of propolis." Thesis, Rhodes University, 2005. http://hdl.handle.net/10962/d1007955.

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Propolis is a traditional value-added product from beekeeping, and has been widely used in medicine and the chemical industry because of its extensive biological activities. In this dissertation some pharmacological properties of propolis extracted by ethanol (EEP) and water (WSP) were studied by means of modem pharmacological methods. The results of the experiments show the following: 1. Both EEP and WSD led to decreased levels of fasting blood glucose (FBG), glycosylated haemoglobin (HBA1c), Fructosamine (FRU), blood urea nitrogen (BUN), uric acid (UA), malonaldehyde (MDA), nitric oxide (NO)

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24

Guité, Pierre. "Pharmacological investigation on the composite nature of the electroretinogram." Thesis, McGill University, 1991. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=59947.

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This research project deals with the electroretinogram (ERG) and the role played by the oscillatory potentials (OPs) in its generation. Investigators are still debating over the cellular origin of these fast components but the current view is that the OPs are produced by structures different from those involved in the genesis of the b-wave (positive wave of the ERG). Another claim would be that the OPs should be considered the primary electrical events produced by the retina and their summation would yield the b-wave. A pharmacological approach was chosen to investigate the OP-b-wave relations

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25

Mao, Kangyi. "Microstructural investigation of tablet compaction and tablet pharmacological properties." Thesis, Massachusetts Institute of Technology, 2010. http://hdl.handle.net/1721.1/62108.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 2010.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>In current tablet manufacturing processes, there is a knowledge gap concerning material transformation and the subsequent impact on tablet properties; this gap presents a barrier to rational formulation / process design. In this study, it was hypothesized that the understanding of tablet microstructure is pivotal in bridging our knowledge about the materials, the manufacturing process, and the tablet properties. A serie

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26

Nyamwaro, Helenne M. "Pharmacological investigation of porcine bladder function and sensory activity." Thesis, Sheffield Hallam University, 2012. http://shura.shu.ac.uk/20130/.

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Overactive bladder (OAB) is a common condition of the lower urinary tract (LUT) that is characterised by urinary urgency, with or without incontinence, accompanied by frequency and nocturia as a result of involuntary urinary bladder contractions. OAB affects millions of people worldwide and has a significant impact on quality of life. A significant amount of research has been undertaken, and is still on-going, investigating the underlying mechanisms of bladder dysfunction and the development of new therapeutic agents for the treatment of LUT conditions. It is now clear that the simplistic ideo

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27

Matera, C. "DESIGN, SYNTHESIS AND PHARMACOLOGICAL INVESTIGATION OF NOVEL BIFUNCTIONAL COMPOUNDS." Doctoral thesis, Università degli Studi di Milano, 2010. http://hdl.handle.net/2434/150203.

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Background - An increasing number of receptor interactions depends on their physical association, and receptor hetero(di)mers usually show pharmacological and functional properties different from those of their constituent partners, thus behaving as new receptor entities. In particular, striatal dopaminergic transmission appears to be under the control of receptor heteromers containing D2 autoreceptors and non-alpha7 nicotinic acetylcholine receptors (nAChRs). This evidence encouraged an in-depth investigation of the biochemical and functional interactions between dopaminergic autoreceptors an

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28

Frazer, Carol-Anne. "An investigation of the pharmacological and non-pharmacological management of postoperative nausea and vomiting induced by patient controlled analgesia." Thesis, University of Ulster, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.314034.

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29

Banjar, W. M. A. "An investigation of the pharmacological responsiveness of human eccrine sweat glands." Thesis, University of Manchester, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.378016.

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30

Hassanali, Azra. "Investigation of nitrergic relaxation in human gastrointestinal muscle using pharmacological methods." Thesis, King's College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298279.

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31

Kholghi, Abeer Othman A. "Pharmacological investigation of clinically achievable concentrations of resveratrol in colorectal cancer." Thesis, University of Leicester, 2014. http://hdl.handle.net/2381/29247.

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Resveratrol, a polyphenol present in red wine and peanuts exerts an array of beneficial effects, including anticancer activity and calorie restriction (CR) mimicry. Work from our laboratory has shown for the first time that low doses of resveratrol, comparable to amounts contained in a glass of red wine significantly reduced adenoma development in ApcMin/+ mice when given with a high fat diet. The protective effect was more pronounced than that caused by higher amounts, equivalent to doses used in clinical trials. The CR activity of resveratrol is mediated via the energy regulator AMP-activate

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32

Hou, Ruihua. "Pharmacological investigation of the regulation of autonomic functions and arousal in humans." Thesis, University of Nottingham, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.438275.

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33

Porter, Richard Hugh Phillip. "An investigation of NMDA and metabotropic glutamate receptors and their pharmacological regulation." Thesis, University of Southampton, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.387118.

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34

Scane, Timothy M. N. "An investigation of the pharmacologically-active principles in amniotic fluid." Thesis, Imperial College London, 1986. http://hdl.handle.net/10044/1/38154.

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35

McFerren, Marcus Anthony. "Traditional plant-based fishing in the Americas an ethnobotanical, phytochemical, and pharmacological investigation /." online access from Digital Dissertation Consortium access full-text, 2000. http://libweb.cityu.edu.hk/cgi-bin/er/db/ddcdiss.pl?9978142.

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36

Hiroi, Noboru 1961. "A pharmacological and neuroanatomical investigation of the conditioned place preference produced by amphetamine /." Thesis, McGill University, 1991. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=74669.

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The present study investigated the neural mechanisms by which environmental stimuli guide conditioned behaviors in the amphetamine conditioned place preference (CPP) paradigm. Systemically injected D1 and D2 dopamine antagonists blocked both acquisition and expression of the CPP: the selective D1 antagonist more effectively blocked expression than the D2 antagonists. The site of action of the antagonists on expression was the nucleus accumbens. Systemically injected reserpine, but not intra-accumbens a-MPT microinjections, also blocked the expression of the amphetamine CPP. Pre-conditioning an

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37

Brain, John George. "Investigation of injury and pharmacological modulation of biliary epithelial cells in ductopenic disease." Thesis, University of Newcastle upon Tyne, 2014. http://hdl.handle.net/10443/2437.

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Senescence and its associated secretory phenotype have been investigated in several vanishing bile duct syndromes. The current study evaluated the presence of senescent biliary epithelial cells (BEC) in acute cellular rejection of human liver allografts to ascertain whether senescent cells contribute to human disease progression in liver transplantation. There was a significant correlation between senescent BEC and grade of rejection. Furthermore there was a significant correlation between grade of rejection and BEC undergoing epithelial to mesenchymal transition (EMT). There was never any ove

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38

Agarwal, Neera. "In vitro and in vivo models investigating pharmacological modulators of the metabolic syndrome." Thesis, Cardiff University, 2010. http://orca.cf.ac.uk/54393/.

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BACKGROUND: Owing to the long-term health risks associated with increased adiposity and the limited efficacy of existing anti-obesity agents, there is an urgent need for further development of alternative therapeutic options to serve as an adjunct to lifestyle measures to address global cardiometabolic risk and thus reduce the risk of developing obesity-related illnesses such as type II diabetes and cardiovascular disease. AIMS & METHODS: The studies presented in this thesis aimed to investigate the effects of novel (CBi antagonist) and existing (metformin) pharmacological agents on compon

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39

Sekar, Sakthivel. "Investigation of Neuronal Effects of Anxiogenic and Antidepressant Medications using Pharmacological Magnetic Resonance Imaging." Thesis, University of Newcastle Upon Tyne, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.519474.

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40

Stanley, Christopher Peter. "An investigation into the pharmacological effects of phytocannabinoids and endocannabinoids in human mesenteric arteries." Thesis, University of Nottingham, 2013. http://eprints.nottingham.ac.uk/28848/.

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Cannabinoids cause both acute and time-dependent vasodilation/vasorelaxation in a range of vascular beds. The vascular effect of cannabinoids is dependent on the cannabinoid ligand, the species studied and the vascular bed used. To date, there have been four studies that have characterised the effects of cannabinoids in humans. Therefore, the aim of this thesis was to characterise the pharmacological effects of cannabinoids in the human mesenteric artery. Written Informed consent was granted for the use of mesenteric arteries collected from patients at the Royal Derby Hospital. Arteries were d

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41

Bitsios, Panagiotis. "A psychophysiological and pharmacological investigation of the autonomic regulation of the pupil in man." Thesis, University of Nottingham, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.337277.

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42

Mutter, F. E. M. "Investigation of Nrf2 activity measures for assessing the toxicological and pharmacological effects of drugs." Thesis, University of Liverpool, 2018. http://livrepository.liverpool.ac.uk/3022492/.

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43

Chandrasekar, Akila [Verfasser]. "Inhibition shapes vulnerability to traumatic brain Injury : pharmacological, toxicological and chemogenetic investigation / Akila Chandrasekar." Ulm : Universität Ulm, 2020. http://d-nb.info/1212115260/34.

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44

Dong, Shuai. "Pharmacologic and Genetic Investigation of PI3K p110delta in Chronic Lymphocytic Leukemia." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1503066319794882.

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45

Yamamoto, Noriyuki. "Development of a selective inhibitor for Syk tyrosine kinase and investigation of its pharmacological activities." 京都大学 (Kyoto University), 2003. http://hdl.handle.net/2433/148369.

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46

Cross, Helen Fiona. "A molecular and pharmacological investigation of the action of ivermectin against Onchocerca ochengi of cattle." Thesis, University of Liverpool, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266171.

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47

MacPherson, Tom. "Genetic and pharmacological investigation of α4-containing GABAA receptors in conditioned behaviours influenced by cocaine". Thesis, University of Sussex, 2014. http://sro.sussex.ac.uk/id/eprint/47585/.

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α4-subunit containing GABAA receptors (α4-GABAARs) are often found co-assembled with δ-subunits in extrasynaptic locations on nucleus accumbens (NAc) medium spiny neurons (MSNs), were they mediate a tonic form of inhibition thought to control the excitability of the neuron. This thesis combines genetic and pharmacological techniques to explore the role of α4-GABAARs in locomotor and reward-conditioned behaviours. Activation of α4-GABAARs by systemic or intra-accumbal administration of THIP, a GABAAR agonist with a preference for δ-subunits, was able to reduce cocainepotentiated locomotor activ

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48

Slade, Rozanna Louise. "Investigation of positron emission tomography for pharmacological assessment of epidermal growth factor receptor-directed therapies." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/18660.

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The epidermal growth factor receptor (EGFR) is overexpressed in many cancers including lung, breast, head and neck and brain. Furthermore, mutations of this receptor have been shown to play crucial roles in response to EGFR-targeted therapies in non small cell lung carcinoma (NSCLC) patients. Imaging EGFR or its function using positron emission tomography (PET) could aid in selection and monitoring patient’s therapeutic response to small molecule tyrosine kinase inhibitors (TKIs) including gefitinib. The aims of this project are first to further investigate the use of a series of cyanoquinolin

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49

Tanczos, Anna Carroll. "Investigations of two distinct pharmacologically relevant proteins using docking studies and molecular dynamics." Thesis, University of Surrey, 2004. http://epubs.surrey.ac.uk/844408/.

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Docking of a flexible ligand to a rigid protein, followed by molecular dynamics (MD) studies to allow movement of the protein is shown to be a useful method for investigating pharmacologically relevant interactions. Studies of MMB lectins (beta-sheet proteins with shallow binding sites) reveal the importance of dimerisation to the activation of all of the carbohydrate binding sites of these lectins, finalising site III into a shape that can accommodate mannose. Aloe lectin was shown to have the overall fold of a MMB lectin and to be capable of forming a dimeric unit, shown to be stable using M

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50

Myung, Chang-Seon. "Pharmacologic investigation of the mechanism of vascular action of polyamines and acetylpolyamines." Scholarly Commons, 1996. https://scholarlycommons.pacific.edu/uop_etds/2673.

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To investigate the mechanism of polyamine- and acetylpolyamine-induced vasodilation, aortic rings from anesthetized New Zealand white rabbits (2.0-2.5 kg) were incubated in modified Krebs-Henseleit buffer, precontracted with phenylephrine (PE), and isometric tension measured. Concentration-response curves were constructed for polyamines (putrescine, spermidine, and spermine) and acetylpolyamines ($N\sp1$-acetylputrescine, $N\sp1$-acetylspermidine, $N\sp8$-acetylspermidine, and $N\sp1$-acetylspermine) in both endothelium-intact and -denuded rings. In both types of rings, all polyamines and acet

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