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Relevant bibliographies by topics / Pharmacology / Dissertations / Theses

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Dissertations / Theses on the topic 'Pharmacology'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Riba, Serrano Jordi. "Human pharmacology of ayahuasca." Doctoral thesis, Universitat Autònoma de Barcelona, 2003. http://hdl.handle.net/10803/5378.

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La ayahuasca es una bebida psicotrópica obtenida de las plantas Banisteriopsis caapi y Psychotria viridis, que ha sido utilizada desde hace siglos en las cuencas de los ríos Amazonas y Orinoco con finalidades mágico-religiosas y en la medicina tradicional de estas áreas geográficas. La bebida contiene alcaloides que muestran actividad inhibidora del enzima monoamino oxidasa o MAO (harmina, harmalina y tetrahidroharmina) y un compuesto alucinógeno (la N,N-dimetiltriptamina o DMT) que es inactivo por vía oral en ausencia de los anteriores. El consumo de ayahuasca se ha ido popularizando lentamen

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2

Cumming, Paul Kenneth. "Pharmacology of cerebral histamine." Thesis, University of British Columbia, 1990. http://hdl.handle.net/2429/30687.

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Four aspects of the function of histaminergic systems were studied in the rat brain: toxicology, catabolism, release in vivo, and high affinity binding of histamine. Preparations of histamine-N-methyltransferase (HNMT) derived from kidney and brain were employed in the radioenzymatic quantification of histamine in biological samples. Tritiated S-adenosyl-L-methionine ([³H]-SAM) served as the co-substrate. A toxicological study was conducted to determine the sensitivity of the HA innervation to prenatal treatment with methylazoxymethanol (MAM), an inhibitor of mitosis. In adult rats, the MAM t

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3

Karbwang, J. "Clinical pharmacology of mefloquine." Thesis, University of Liverpool, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.234865.

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4

Ordway, Gregory A. "Molecular Pharmacology of Antidepressants." Digital Commons @ East Tennessee State University, 2006. https://dc.etsu.edu/etsu-works/8657.

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5

Langford, Nigel James. "Beta-receptor pharmacology and therapeutics." Thesis, University of Birmingham, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.404060.

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6

Hahn, Robert G. "Clinical pharmacology of infusion fluids." Linköpings universitet, Anestesiologi med intensivvård, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-91319.

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Fluids are used for intravenous infusion during practically all surgeries, but several different compositions are available on the market. Crystalloid fluids comprise lactated or acetated Ringer solutions, normal saline, Plasma-Lyte, hypertonic saline, and glucose. They lack allergic properties but are prone to cause peripheral tissue oedema. Their turn over is governed by physiological factors such as dehydration and drug effects. Colloid fluids include hydroxyethyl starch, albumin, dextran, and gelatin. These fluids have various degrees of allergic properties and do not promote peripheral o

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7

Farquhar, Michelle Jane. "Molecular pharmacology of chimeric peptides." Thesis, University of Wolverhampton, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.247780.

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8

Pasanisi, F. "Clinical pharmacology of calcium antagonists." Thesis, University of Glasgow, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.381477.

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9

Al-Malki, Waleed Hassan. "Pharmacology of aqueous humour formation." Thesis, University of Glasgow, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.443403.

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10

Ward, S. A. "The biochemical pharmacology of primaquine." Thesis, University of Liverpool, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.354530.

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11

Moss, Nicholas K. "TRPC channel activation and pharmacology." Thesis, University of Leeds, 2015. http://etheses.whiterose.ac.uk/9713/.

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Ion channel permeability and calcium ion (Ca2+) signalling are essential in regulating cellular responses to external and internal stimuli. Changes in the Ca2+ signalling machinery during pathologies of the cardiovascular system are a common occurrence, with an underlying deregulation of Ca2+ signalling a driving force for many pathological processes. This study particularly focusses on the change in Ca2+ regulatory mechanisms under conditions of adversity that are often attributed to pathological environments. An elevation of inflammatory mediators and an acidic extracellular environment can

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12

Appleby, Hollie Leanne. "Orai channel physiology and pharmacology." Thesis, University of Leeds, 2016. http://etheses.whiterose.ac.uk/15950/.

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Background: Cardiovascular disease is often characterised by functional and structural changes in the blood vessel wall, usually associated with endothelial dysfunction. Therefore, interest in targeting the dysfunctional endothelial cell has heightened. Ca2+ signalling is crucial to endothelial cell physiology as it drives a number of intracellular signalling pathways. Store-operated Ca2+ entry (SOCE) mediated by Orai1 channels is of particular interest as it provides a major Ca2+ influx pathway in endothelial cells, driving cell migration and proliferation, ultimately contributing to endothel

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13

Keiser, Michael James. "Relating protein pharmacology by ligand chemistry." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2009. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3378494.

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14

Sherwin, Catherine M. T., and n/a. "Clinical pharmacology of aminoglycosides in neonates." University of Otago. Dunedin School of Medicine, 2009. http://adt.otago.ac.nz./public/adt-NZDU20090821.160736.

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The aims of this Thesis were to investigate early markers of neonatal sepsis and patient-factors affecting the pharmacokinetics and pharmacodynamics (PKPD) of aminoglycosides in the treatment of neonatal sepsis. A prospective cohort study of neonates commenced on gentamicin for suspected sepsis was performed between 1 July 2002 and 28 February 2007. Receiver operator characteristics (ROC) plots were used to assess potential markers of sepsis against culture positive sepsis. When sepsis was first suspected, the most promising tests were interleukin (IL) IL-12(p70) with an area under the curve (

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15

Jonsson, Kent-Olov. "Pharmacology of Palmitoylethanolamide and Related Compounds." Doctoral thesis, Umeå : Dept. of pharmacology and clinical neuroscience, Univ, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-445.

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16

Wells, Christine. "Hippopcampal function : theta, pharmacology and novelty." Thesis, University of Leeds, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.540763.

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17

Beckett, P. A. "Pharmacology of airway remodelling in asthma." Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.596514.

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18

Ho, M. T. B. "Pharmacology of the orphan opioid receptor." Thesis, University of Cambridge, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.604104.

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The neuropeptide nociceptin/orphanin FQ (OFQ) was recently identified as the endogenous agonist of the orphan opioid receptor ORL<SUB>1</SUB>. In this thesis pharmacological studies on the ORL<SUB>1</SUB> receptor were advanced by the comparison of the potencies and efficacies of several ligands at the rat ORL<SUB>1</SUB> receptor stably transfected into chinese hamster ovary (CHO) cells, with those at the native receptor in the central (frontal cortex) and peripheral (anococcygeus muscle) nervous systems. Most notably, the work involved a close examination of the pharmacology of the first sel

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19

Baker, Jillian G. "Molecular pharmacology of Î²-adrenoceptor ligands." Thesis, University of Nottingham, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.401579.

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20

Little, Margaret. "The cellular pharmacology of thiopurine drugs." Thesis, University of Newcastle Upon Tyne, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.405347.

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21

Bangchang, Kesara Na. "Clinical and biochemical pharmacology of mefloquine." Thesis, University of Liverpool, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.317200.

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22

Riviere, Judith Helen. "Biochemical and clinical pharmacology of Mefloquine." Thesis, University of Liverpool, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.328152.

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23

Bailey, A. C. "Biochemistry and pharmacology of beta-bungarotoxin." Thesis, University of Essex, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.372585.

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24

Al-Zamil, Zeid Muhammed Zeid. "Pharmacology of isolated mammalian spinal cord." Thesis, University of Southampton, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.280402.

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25

Barkan, Kerry. "An investigation into glucagon receptor pharmacology." Thesis, University of Warwick, 2017. http://wrap.warwick.ac.uk/98781/.

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The glucagon receptor (GCGR), a family B G protein-coupled receptor (GPCR), plays an important role in regulating blood glucose levels through its ability to bind the 29 amino acid peptide hormone, glucagon (GCG). Antagonising GCG action is a potential therapeutic option for reducing hepatic glucose production. However, GCG-based therapy is currently limited to acute emergency treatment of hypoglycemia in patients with type 1 diabetes (T1D) (Habegger et al., 2010). Further insight into GCGR-mediated signalling pathways and mechanism of activation may provide the basis for therapeutic developme

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26

Lewis, Clive Jonathan. "Pharmacology of the 'putative' Beta4-adrenoceptor." Thesis, University of Cambridge, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.615696.

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27

Martin, Richard John. "Veterinary pharmacology, ion-channels and anthelmintics." Thesis, University of Edinburgh, 1997. http://hdl.handle.net/1842/30450.

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In this collection of papers modes of action of anthelmintic and anaesthetic drugs used in Veterinary Practice are investigated using electrophysiological techniques. New preparations and analytical techniques for investigation are described along with properties of ion-channel target sites. The pharmacology of piperazine, levamisole, pyrantel, morantel, oxtantel, avermectins, cyclic depsipeptides, ketamine, metomidate, alphaxalone and xylazine are studied. This information is reviewed in formats suitable for graduate and undergraduate study. Two-micropipette current-clamp and voltage-clamp te

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28

Ahtyamova, D. V. "Anti-aging pharmacology: promises and pitfalls." Thesis, Київський національний університет технологій та дизайну, 2018. https://er.knutd.edu.ua/handle/123456789/10636.

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29

Novozhilova, Ekaterina B. "Physiology and pharmacology of flatworm muscle." [Ames, Iowa : Iowa State University], 2008.

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30

Spratt, James Christopher Samuel. "Endothelin : cardiovascular pharmacology, physiology & pathophysiology." Thesis, University of Edinburgh, 2003. http://hdl.handle.net/1842/23202.

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31

Winstanley, Peter Andrew. "The pharmacology and toxicology of amodiaquine." Thesis, University of Liverpool, 1988. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.237571.

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32

Nielsen, Carsten K. "Studies on the preclinical pharmacology of oxycodone /." St. Lucia, Qld, 2003. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe17560.pdf.

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33

Yubero, Lahoz Samanta 1985. "MDMA pharmacology in humans and serotonergic effects." Doctoral thesis, Universitat Pompeu Fabra, 2013. http://hdl.handle.net/10803/145481.

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3,4-methylenedioxymethamphetamine (MDMA, ecstasy) is one of the most abused recreational drugs in the world. It has been extensively reported that this drug inhibits its own metabolism by inhibiting a polymorphic liver enzyme, CYP2D6, which is responsible for the clearance of one quarter of drugs used in therapeutics. This phenomenon has important clinical implications, since MDMA users display a higher prevalence of psychopathology, particularly of mood disorders, compared to control population. Importantly, these psychiatric diseases are treated with drugs most of them substrate of thi

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34

McGonigle, Ian Vincent. "Molecular pharmacology of an insect GABA receptor." Thesis, University of Cambridge, 2010. https://www.repository.cam.ac.uk/handle/1810/226857.

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Cys-loop receptors are ligand-gated ion channels that are involved in fast synaptic neurotransmission in the central and peripheral nervous system. The Cys-loop receptor RDL ('resistant to dieldrin') is a GABA-gated chloride channel from Drosophila melanogaster and is a major target site for insecticides. The aim of this dissertation was to characterise RDL receptors with particular focus on the agonist binding site. To assess the potency of a range of GABA analogues on RDL receptors, I expressed receptors in Xenopus oocytes and used voltage-clamp electrophysiology to detect receptor responses

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35

Bolton, John Francis. "Urinary tract smooth muscle physiology and pharmacology." Thesis, University of Bristol, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.432685.

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36

Hand, C. W. "Studies on the human pharmacology of opiates." Thesis, University of Oxford, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.379946.

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37

Mallon, Andrew Peter. "An investigation of NMDA receptor subunit pharmacology." Thesis, University of Glasgow, 2004. http://theses.gla.ac.uk/3127/.

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N-Methyl-D-aspartate (NMDA) receptors are critically involved in synaptic transmission, neural development and various forms of neuronal plasticity including long-term potentiation (LTP) and long-term depression (LTD). They are also involved in the production of neuronal damage following excessive activation by glutamate released as a result of hypoxia or ischaemia. Each heteromeric receptor includes one or two NRl subunits, at least two of the four NR2A-D subunits and less usually the NR3AJB subunits. This study demonstrates that the putative NR2B subunit-containing NMDA receptor antagonist R

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38

Whittaker, Steven Robert. "The molecular pharmacology of purine CDK inhibitors." Thesis, Institute of Cancer Research (University Of London), 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.404908.

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39

Croughton, Karen. "Novel pharmacology of the lipophilic antifolate methylbenzoprim." Thesis, University of Nottingham, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368236.

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40

Roberts, Claire. "5-HT terminal autoreceptor : pharmacology and function." Thesis, University of Nottingham, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.263094.

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41

Brown, Andrew M. G. "Biochemistry, tissue culture and pharmacology of Tanacetum." Thesis, University of Nottingham, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.363563.

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42

Kasorn, Anongnard. "The molecular pharmacology of lysophosphatidic acid receptors." Thesis, University of Nottingham, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.441003.

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43

Alyami, A. M. "Pharmacology of benzodiazepines and GABA in intestine." Thesis, University of Bradford, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.384251.

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44

Barnes, Matthew Joseph. "The cellular pharmacology of antifolates in leukaemia." Thesis, University of Newcastle Upon Tyne, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.244470.

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45

Yule, S. M. "The clinical pharmacology of cyclophosphamide in children." Thesis, University of Newcastle Upon Tyne, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.309831.

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46

Pearson, Hugh Anthony. "Physiology and pharmacology of insect calcium channels." Thesis, University College London (University of London), 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.308295.

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47

Milton, Kevin Ashley. "The clinical and biochemical pharmacology of halofantrine." Thesis, University of Liverpool, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.291722.

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48

Choonara, I. A. "Clinical pharmacology of warfarin and vitamin K." Thesis, University of Liverpool, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.383440.

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49

Clark, Kenneth Lyle. "Pharmacology of renal dopamine and angiotensin receptors." Thesis, Open University, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.293275.

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Dopamine and angiotensin II (Ang II) are naturally occurring molecules with profound but contrasting effects in the kidney. This study aimed to increase knowledge of the pharmacology and physiology of renal dopamine and angiotensin receptors. Little evidence was found to the presence of dopamine DA1 receptors, mediating dilatation, or angiotensin receptors, mediating constriction, in canine isolated main branch, interlobar, or arcuate renal artery rings. However, in anaesthetised dogs, renal vascular angiotensin and dopamine receptors were clearly demonstrated, suggesting that they are located

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50

Ridley, John Malcolm. "Pharmacology of the HERG Kâº channel." Thesis, University of Bristol, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.411068.

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