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Journal articles on the topic 'Pharmacotherapy safety'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

O'Malley, Kieran D. "Safety of Combined Pharmacotherapy." Journal of the American Academy of Child & Adolescent Psychiatry 36, no. 11 (1997): 1489–90. http://dx.doi.org/10.1097/00004583-199711000-00005.

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2

O'Malley, Kieran D. "SAFETY OF COMBINED PHARMACOTHERAPY." Journal of the American Academy of Child & Adolescent Psychiatry 36, no. 11 (1997): 1489–90. http://dx.doi.org/10.1016/s0890-8567(09)66552-7.

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3

Roehrs, Timothy, and Thomas Roth. "Safety of Insomnia Pharmacotherapy." Sleep Medicine Clinics 1, no. 3 (2006): 399–407. http://dx.doi.org/10.1016/j.jsmc.2006.06.010.

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4

Pasechnik, I. N., V. Yu Rybintsev, and P. A. Talyzin. "Safety of pharmacotherapy: what's new?" Anesteziologiya i Reanimatologiya, no. 5 (2019): 47. http://dx.doi.org/10.17116/anaesthesiology201905147.

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5

Sychev, D. A. "Pharmacotherapy Safety 360°: NOLI NOCERE!" Pharmacogenetics and Pharmacogenomics, no. 1 (July 19, 2023): 3–5. http://dx.doi.org/10.37489/2588-0527-2023-1-3-5.

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The Russian Congress «Pharmacotherapy Safety 360°: NOLI NOCERE!» was successfully held at the Russian Ministry of Health in May 2023, providing a high-level, expert platform to discuss current and topical issues of pharmacovigilance and pharmacotherapy safety for different patient groups, including pediatrics, gerontology and geriatrics, pregnant women, patients with orphan and oncological diseases. Extensive scientific topics covered the most significant aspects of the pharmacotherapy safety in various fields, including cardiology, gastroenterology, pulmonology and allergology, endocrinology,

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6

Tezel, Tongalp H. "Intraocular pharmacotherapy: specificity and safety issues." Expert Review of Ophthalmology 2, no. 5 (2007): 671–75. http://dx.doi.org/10.1586/17469899.2.5.671.

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7

Lukina, Yu V., N. P. Kutishenko, S. Yu Martsevich, and O. M. Drapkina. "Issues of concern and development of classifications of the main parameters of therapy quality and compliance. Part III: quality of pharmacotherapy." Cardiovascular Therapy and Prevention 23, no. 12 (2024): 4268. https://doi.org/10.15829/17288800-2024-4268.

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This article is the third work in a series of publications on consideration of the main parameters of therapy quality and compliance and the development of their classifications. The aim is to determine, based on scientific literature data, the main parameters reflecting the quality of therapy and to develop their classification.According to the World Health Organization, more than half of all drugs are prescribed and sold improperly, and half of all patients take their medications inadequately. To date, there is no generally accepted terminology and classification regarding the quality of the

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8

Wigal, Sharon B. "Safety and Efficacy Limitations of ADHD Pharmacotherapy." Journal of Pediatrics 154, no. 5 (2009): I—S43. http://dx.doi.org/10.1016/j.jpeds.2009.01.017.

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9

Masand, Prakash S., Farhan S. Fazal, and Ashwin A. Patkar. "Safety Considerations in Pharmacotherapy of Bipolar Disorder." CNS Spectrums 9, S12 (2004): 16–26. http://dx.doi.org/10.1017/s1092852900028856.

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AbstractBipolar disorder is a chronic, frequently relapsing illness with a prevalence of 1.2% to 3.4% in the general population. It is associated with high disability, higher comorbidity due to medical illnesses, and significant social and economical consequences for patients, their families, and society. The episodic nature of this disease warrants rational use of medications and proper monitoring for adverse events. Various drug classes, such as mood stabilizers, antipsychotics, benzodiazepines, and antidepressants, are used for the acute and maintenance treatment of bipolar disorder. Each g

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10

Johannessen Landmark, Cecilie, and Svein I Johannessen. "Pharmacotherapy in epilepsy – does gender affect safety?" Expert Opinion on Drug Safety 15, no. 1 (2015): 1–4. http://dx.doi.org/10.1517/14740338.2016.1117606.

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11

Zamaleeva, R. S., N. A. Cherepanova, S. V. Bukatina, and N. E. Domracheva. "Pharmacotherapy during pregnancy." Voprosy ginekologii, akušerstva i perinatologii 20, no. 3 (2021): 146–54. http://dx.doi.org/10.20953/1726-1678-2021-3-146-154.

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Prescription of any medications during pregnancy deserves careful selection due to their possible effect on the fetus, as well as altered metabolism against gestation. Indications for prescribing medications during pregnancy may be chronic somatic pathology, acute diseases, pregnancy complications and the need for their prevention, as well as taking medications recommended additionally during pregnancy – multivitamin supplements, specific vitamin and microelement preparations. The article provides an analysis of essential prenatal medications, taking into account their safety and effectiveness

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12

Witczak, Izabela, Łukasz Rypicz, Mária Šupínová, et al. "Patient Safety in the Process of Pharmacotherapy Carried Out by Nurses—A Polish–Slovak Prospective Observational Study." International Journal of Environmental Research and Public Health 18, no. 19 (2021): 10066. http://dx.doi.org/10.3390/ijerph181910066.

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Pharmacotherapy, i.e., the use of medicines for combating a disease or its symptoms, is one of the crucial elements of patient care. Nursing workloads in the pharmacotherapy process prove that nurses spend 40% of their work on the management of medications. This study was aimed at the determination and comparison of safety levels at the nurse-managed stage of the pharmacotherapy process in Poland and Slovakia by identifying the key risk factors which directly affect patient safety. The study involved a group of 1774 nurses, of whom 1412 were from Poland and 362 were from Slovakia. The original

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13

Burchinsky, Sergiy. "Problem of interrelations of effi cacy and safety during pharmaco therapy in angioneurology: focus on ginkgo preparations." Ukrains'kyi Visnyk Psykhonevrolohii 27, no. 2 (99) (2019): 73–77. http://dx.doi.org/10.36927/2079-0325-v27-is2-2019-16.

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In the present article a modern criteria defi ned the terms "effi cacy" and "safety" during pharmacotherapy in cerebrovascular pathology have been looked. A main risks and possible adverse eff ects of widely used nootropic and vasotropic drugs in angioneurologic practice have been analyzed. Advantages of use the neurotropic phytodrugs and especially preparations of Ginkgo biloba have been looked in details. Use as an optimal instrument of pharmacotherapy in cerebrovascular pathology the drug Bilobil-Intens has been grounded based on the point of view of its complex clinical-pharmacological eff

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14

Sychev, D. A. "Clinical and pharmacological technologies of personalized medicine: what now and what will happen?" V.M. BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY, no. 4-1 (December 9, 2019): 24–25. http://dx.doi.org/10.31363/2313-7053-2019-4-1-24-25.

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«Omic» biomarkers are promising tools for personalizing pharmacotherapy, including and mental illness because allow predicting an individual profile of the effectiveness and safety of psychotropic drugs. «Omics» biomarkers include pharmacogenomic, pharmacoproteomic, pharmacotranscriptome, pharmacometabolic biomarkers. A methodology for the development of «omcs» biomarkers of personalization of pharmacotherapy is presented: from assessing the problems of pharmacotherapy to the system of implanting biomarkers into real clinical practice.

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15

Mubarakshina, O. A., M. N. Somova, and G. A. Batishcheva. "Modern combination antihypertensive pharmacotherapy." Systemic Hypertension 15, no. 4 (2018): 30–33. http://dx.doi.org/10.26442/2075082x.2018.4.180149.

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Achievement of target blood pressure levels is one of the main issues in antihypertensive pharmacotherapy. The article presents updated 2018 European Guidelines recommendations on target blood pressure levels in antihypertensive therapy and combined antihypertensive pharmacotherapy advantages. Modern fixed combinations including those with three active agents are discussed. A review of studies that show effectiveness and safety of long acting dihydropyridine calcium channel blocker amlodipine, thiazid-like diuretic indapamide, and angiotensin-converting enzyme inhibitor perindopril arginine fi

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16

Haen, E. "Therapeutic Drug Monitoring in Pharmacovigilance and Pharmacotherapy Safety." Pharmacopsychiatry 44, no. 06 (2011): 254–58. http://dx.doi.org/10.1055/s-0031-1286285.

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17

Bender, Stefan, Thomas Linka, Jörg Wolstein, et al. "Safety and efficacy of combined clozapine–lithium pharmacotherapy." International Journal of Neuropsychopharmacology 7, no. 1 (2004): 59–63. http://dx.doi.org/10.1017/s1461145703003870.

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18

Reffelmann, Thorsten, and Robert A. Kloner. "Pharmacotherapy of erectile dysfunction: focus on cardiovascular safety." Expert Opinion on Drug Safety 4, no. 3 (2005): 531–40. http://dx.doi.org/10.1517/14740338.4.3.531.

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19

Lebedev, P. A., A. A. Garanin, and N. L. Novichkova. "Pharmacotherapy of gout – modern approaches and prospects." Modern Rheumatology Journal 15, no. 4 (2021): 107–12. http://dx.doi.org/10.14412/1996-7012-2021-4-107-112.

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The article discusses modern approaches to the gout treatment, presented in foreign and domestic clinical guidelines. While the use of urate-lowering therapy for gout is a necessary and highly effective strategy, in the case of asymptomatic hyperuricemia, the benefits of this approach are not clear. The safety and efficacy of colchicine, as well as its cardioprotective properties, were noted in comorbid patients suffering from gout and cardiovascular diseases. Comparative data on safety and efficacy of the main urate-lowering drugs, allopurinol and febuxostat, are presented. It has been shown

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20

Ochakovskaya, I. N., V. M. Durleshter, O. G. Ni, and N. E. Shabanova. "THE RESULTS OF A SURVEY OF SURGEONS ON THE SAFETY OF PHARMACOTHERAPY." Kuban Scientific Medical Bulletin 25, no. 6 (2018): 127–34. http://dx.doi.org/10.25207/1608-6228-2018-25-6-127-134.

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Aim. The study was conducted to assess the level of awareness of surgeons about the principles of safe perioperative pharmacotherapy.Materials and methods. The survey of surgeons was conducted in 2018 on the basis of a questionnaire made by the authors, consisting of 60 questions and tasks, divided into 6 thematic blocks. The respondents had to demonstrate their knowledge both in the field of general principles of safe pharmacotherapy and private issues of using analgesics, anticoagulants, antibiotics in the perioperative period. The results of the survey were assessed as a percentage (proport

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21

Gouni-Berthold, Ioanna, and Heiner K. Berthold. "Current Options for the Pharmacotherapy of Obesity." Current Pharmaceutical Design 25, no. 18 (2019): 2019–32. http://dx.doi.org/10.2174/1381612825666190708192630.

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650 millions of adults are obese worldwide - in the US alone, forty percent of the adults are obese. Although the obesity pandemic is constantly expanding at very high costs for health care systems, the currently available options of pharmacotherapy for obesity are rather limited. Despite intensive research efforts, the vast majority of the anti-obesity drugs developed up to now have a rather limited efficacy and/or safety profile. In the last fifty years, various drugs reached advanced states of clinical development but were either never marketed or were initially approved but withdrawn later

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22

Trukhan, Dmitry I. "Rational pharmacotherapy in real clinical practice through the prism of multimorbidity and drug safety." Clinical review for general practice 1, no. 2 (2020): 29–39. http://dx.doi.org/10.47407/kr2020.1.2.00015.

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Currently, multimorbidity/comorbidity and drug safety are important components of rational pharmacotherapy in real clinical practice. Cardiovascular diseases occupy a leading place in the structure of non-infectious pathology of the adult population, being the main cause of early disability and premature death. In a review article, using clinical examples, the issues of rational pharmacotherapy in patients with cardiovascular diseases and concomitant comorbid/multimorbid pathology are considered.

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23

Fedorowicz, Olga, Łukasz Rypicz, Anna Wiela-Hojeńska, Ewa Jaźwińska-Tarnawska, and Izabela Witczak. "Application of Novel Pharmacists’ Risk in Pharmacotherapy (PHARIPH) Scale for Identification of Factors Affecting the Safety of Hospital Pharmacotherapy—An Observational Pilot Study." International Journal of Environmental Research and Public Health 19, no. 3 (2022): 1337. http://dx.doi.org/10.3390/ijerph19031337.

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Background: The widespread occurrence of medication errors (MEs) has become a global problem because it poses a serious threat to the health and lives of patients, can prevent the achievement of treatment goals, undermines patient trust in the health care system, and increases treatment costs. The purpose of this study was to develop an appropriate tool to identify key risk factors that hospital pharmacists believe threaten pharmacotherapy safety in the hospital. Methods: A diagnostic survey method using the authors’ PHARIPH (Pharmacists’ Risk in Pharmacotherapy) scale and authorial questions

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24

Lepakhin, V. K., and A. V. Astakhova. "“Implementing the pharmacovigilance system and publishing this journal, we were helping healthcare providers cultivate the sense of professional and civic responsibility”." Safety and Risk of Pharmacotherapy 12, no. 1 (2024): 7–13. http://dx.doi.org/10.30895/2312-7821-2024-12-1-7-13.

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The origins of the journal Safety and Risk of Pharmacotherapy date back to 1994. The journal was published as Safety of Medicinal Products, Safety of Medicines, and Safety of Medicinal Products and Pharmacovigilance. In Russia, this journal has always been the only specialised scientific publication covering exclusively the safety of pharmacotherapy. Alla V. Astakhova, Candidate of Medical Sciences, headed the journal from 1994 to 2015.The history of the journal is closely intertwined with the history of the pharmacovigilance system in Russia. Vladimir K. Lepakhin, Doctor of Medical Sciences,

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25

Verveda, A. B., V. B. Vasilyuk, G. I. Syraeva, M. V. Faraponova, and A. V. Popov. "Implementation of quantitative integral analysis in assessing events associated with safety issues during clinical trials: focusing on trastuzumab." Kachestvennaya Klinicheskaya Praktika = Good Clinical Practice, no. 4 (January 17, 2025): 21–34. https://doi.org/10.37489/2588-0519-2024-4-21-34.

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The authors developed a methodology for an in-depth study of the safety of pharmacotherapy based on a quantitative integrated analysis of adverse events in the context of clinical trials. The methodology was tested using data obtained during a bioequivalence study of trastuzumab.Objective. Practical implementation of the approaches developed by the authors for the individualized assessment of safety of pharmacotherapy based on quantitative integral analysis of adverse events.Materials and methods. This five-step algorithm modifies information regarding registered adverse events during clinical

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26

Feoktistova, Yu N., E. E. Eliseyeva, E. A. Poddubny, S. V. Voronin, and B. I. Geltster. "Safety issues of pharmacotherapy of respiratory infections in pregnancy." Russian Pulmonology, no. 2 (January 1, 2012): 30–33. http://dx.doi.org/10.18093/0869-0189-2012-0-2-30-33.

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27

Burdziński, Igor, Łukasz Ledziński, and Grzegorz Grześk. "Safety of hypertension pharmacotherapy in recreational scuba diving patients." Farmacja Polska 77, no. 5 (2021): 324–28. http://dx.doi.org/10.32383/farmpol/138767.

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28

Burchinskiy, S. G., A. Yu Gonchar, and K. V. Raychenko. "The problem of nootropic pharmacotherapy safety in neurological practice." INTERNATIONAL NEUROLOGICAL JOURNAL, no. 7.93 (December 19, 2017): 56–60. http://dx.doi.org/10.22141/2224-0713.7.93.2017.116549.

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29

Bolieva, Bolieva L. Z., and Archegova E. G. Archegova. "Pharmacotherapy of asthma in pregnant women: issues of safety." Therapy 2_2020 (May 6, 2020): 62–68. http://dx.doi.org/10.18565/therapy.2020.2.62-68.

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30

Chukhareva, Chukhareva N. A., Kartseva V. S. Kartseva, Esayan R. M. Esayan, et al. "Pharmacotherapy for heartburn during pregnancy: Safety of reserve drugs." Akusherstvo i ginekologiia 6_2016 (June 27, 2016): 67–72. http://dx.doi.org/10.18565/aig.2016.6.67-72.

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31

Reid, Ian R. "Pharmacotherapy of osteoporosis in postmenopausal women: focus on safety." Expert Opinion on Drug Safety 1, no. 1 (2002): 93–107. http://dx.doi.org/10.1517/14740338.1.1.93.

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32

Karateyev, A. E. "Treating osteoarthrosis in terms of the safety of pharmacotherapy." Modern Rheumatology Journal, no. 1 (March 25, 2009): 51. http://dx.doi.org/10.14412/1996-7012-2009-524.

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33

Shikh, Shikh E. V., Makhova A. A. Makhova, and Krasnoperova E. V. Krasnoperova. "Modern strategies for safety of iron deficiency pharmacotherapy improving." Therapy 5_2023 (July 18, 2023): 156–64. http://dx.doi.org/10.18565/therapy.2023.5.156-164.

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34

BS, Aymun Razzak, Dena Kamel BS, Nada Alhaj BS, Mohammed Omar Almosa BS, Ismail Eter BS, and Omar Abdelaziz MD. "A Systematic Review on Pharmacological Interventions in Borderline Personality Disorder: Efficacy, Safety, and Management Challenges." International Neuropsychiatric Disease Journal 22, no. 1 (2025): 19–27. https://doi.org/10.9734/indj/2025/v22i1465.

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Background: Borderline Personality Disorder (BPD) is a complex psychiatric condition characterized by emotional instability, impulsivity, and interpersonal difficulties. Pharmacotherapy is commonly used in addition to psychotherapy to manage specific symptom domains of BPD. This systematic review aims to evaluate the safety and efficacy of pharmacological interventions in BPD. Methods: A systematic literature search was conducted using Ovid Medline. The initial search identified 1,689 papers, which were screened based on relevance to the topic, resulting in 12 studies that met the inclusion cr

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35

Babich, A. E., E. V. Luchinina, O. G. Kompaniets, and N. A. Zubareva. "Rebamipid in real clinical practice: quality of life and safety of use." Medical alphabet, no. 35 (December 18, 2021): 7–11. http://dx.doi.org/10.33667/2078-5631-2021-35-7-11.

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The aim of the study was to assess the tolerability and impact on the quality of life of pharmacotherapy for gastric ulcer, erosive gastritis using regimens including rebamipide. The quality of life of patients was assessed using the SF-36 questionnaire. Pharmacotherapy of gastric ulcer with the inclusion of rebamipide as part of the conventional treatment regimen provides data comparable to the healthy group on the scales of physical functioning, role functioning due to physical condition, pain intensity, general health, and vital activity. The results of our own research and data from litera

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36

Mohammed, Baba Sulemana, and Matthew Aidoo. "Drug Treatment of Patients with Liver Cirrhosis in a Tertiary Hospital in Northern Ghana: Does It Comply with Recommended Guidelines?" International Journal of Hepatology 2020 (May 29, 2020): 1–7. http://dx.doi.org/10.1155/2020/9750194.

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The diverse influence of liver function on drug disposition can lead health-care practitioners to inappropriate drug selection, inappropriate drug dosing, or some level of therapeutic negativism. The aim of this study was to assess how drug prescribing in patients with liver cirrhosis at the Tamale Teaching Hospital comply with recommendations of pharmacotherapy and safety guidelines. A prospective cross-sectional study was conducted from February to July, 2019, at the medical ward of the Tamale Teaching Hospital. A total of 152 liver cirrhotic patients were included in this study. Common etio

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37

Egorova, E. A., A. M. Beitullaev, A. V. Matveev, and K. N. Koryanova. "Review of publications on drug-related problems investigations in osteoporosis patients." Pharmacy & Pharmacology 11, no. 5 (2024): 412–21. http://dx.doi.org/10.19163/2307-9266-2023-11-5-412-421.

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A chronic form of osteoporosis (OP) substantiates a long-term pharmacotherapy of patients, which increases the risk of adverse drug reactions (ADRs) during the therapy. The enhancement of requirements to the quality of safety monitoring carried out in the context of pharmacovigilance and the newly identified safety problems require an improvement of the system of quality control of medicinal products (MPs).The aim of the work was to review the application of a new promising method for monitoring the drug safety – the system of Drug-Related Problems (DRP) in the osteoporosis pharmacotherapy.Mat

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38

Litvinenko, T. S., A. V. Safronenko, E. V. Gantsgorn, M. A. Shishov, and T. A. Polinskaya. "Pharmacotherapy’s safety audit at the outpatient clinic level." South Russian Journal of Therapeutic Practice 6, no. 1 (2025): 73–80. https://doi.org/10.21886/2712-8156-2025-6-1-73-80.

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Objective: to analyze the structure of drug prescriptions and adverse drug reactions (ADRs) in the conditions of application of the developed risk-based approach to the audit of pharmacotherapy in patients of outpatient clinics. Materials and methods: the basis for the study was an outpatient clinic in Rostov-on-Don. The sample consisted of 680 patients observed by a general practitioner. Based on the results of a retrospective analysis of spontaneous reports of ADRs registered in the Rostov region for 2019-2021, a risk-based questionnaire was developed. 50 % (n = 340) of the observed patients

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39

Batishcheva, Galina Alexandrovna, Sofia Alekseevna Korchagina, Tatyana Evgenievna Kotelnikova, and Natalya Yurievna Goncharova Natalya Yurievna. "REAL CLINICAL PRACTICE OF TREATMENT OF CARDIAC ARRHYTHMIAS IN LOCOMOTIVE CREW WORKERS." Medical Scientific Bulletin of Central Chernozemye (Naučno-medicinskij vestnik Centralʹnogo Černozemʹâ) 1, no. 91 (2023): 33–42. http://dx.doi.org/10.18499/1990-472x-2023-1-91-33-42.

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Cardiac arrhythmias create prerequisites for the occurrence of sudden cardiac death in the workplace, which poses a threat to the safety of train traffic. A targeted examination of locomotive crew workers (LCW) includes the diagnosis of cardiac arrhythmias for effective and safe pharmacotherapy. A retrospective analysis of 100 medical histories of machinists and assistant machinists hospitalized in the cardiology department of the Private healthcare institution "Clinical Hospital "Russian Railways-medicine" Voronezh", who have the following types of cardiac arrhythmias: supraventricular extras

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40

Kadyseva, E. R., V. N. Khaziakhmetova, L. Yu Kulagina, and V. A. Kurylev. "Ensuring medication safety on the case of a multidisciplinary hospital." Glavvrač (Chief Medical Officer), no. 10 (October 12, 2024): 24–30. http://dx.doi.org/10.33920/med-03-2410-02.

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The article discusses the process of management and control in matters of ensuring medication safety at the Republican Clinical Hospital of the Ministry of Health of the Republic of Tatarstan. Registration of adverse drug reactions is a mandatory measure for monitoring the safety of pharmacotherapy.

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41

Tadtaeva, Z. G., A. N. Galustyan, V. V. Rusanovsky, et al. "Pharmacotherapy of insomnia in childhood." FARMAKOEKONOMIKA. Modern Pharmacoeconomics and Pharmacoepidemiology 15, no. 2 (2022): 284–93. http://dx.doi.org/10.17749/2070-4909/farmakoekonomika.2022.127.

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Insomnia is the most common form of sleep disturbance in childhood. Sleep disorders and a decrease in its duration and quality lead to the development of cognitive disorders, change emotional and behavioral functions of the developing organism, and negatively affect medical and psychological aspects that require medical correction. The article provides an overview of current literature data on pharmacological approaches to insomnia therapy in childhood. The general principles of treatment and the use of various pharmacological groups of drugs are discussed. It is shown that pharmacotherapy of

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42

Kurowska, Patrycja, and Wojciech Giermaziak. "Safety of Metamizole Therapy." Biuletyn Głównej Biblioteki Lekarskiej 56, no. 380 (2023): 55–70. https://doi.org/10.2478/bgbl-2023-0003.

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Summary Metamizole (dipyrone) is a popular non-opioid analgesic and antipyretic drug. In many countries, it has been banned because of a possible association with several adverse drug reactions; in some countries it is available as a prescribed drug. In Poland, dipyrone is sold as an over-the-counter (OTC) drug. The aim of the paper is to determine the types, frequency and the severity of the adverse events caused by dipyrone; based on the latest literature research. Due to the possibility of these events, it is necessary to raise awareness of the principles of safe pharmacotherapy and to draw

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43

Hwang, Hun-Gyu, and Yang-Ki Kim. "Pharmacotherapy for pulmonary embolism: new anticoagulants." Journal of the Korean Medical Association 65, no. 7 (2022): 442–48. http://dx.doi.org/10.5124/jkma.2022.65.7.442.

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Background: Pulmonary embolism is associated with reduced survival and considerable economic burden worldwide. In Korea, the incidence of pulmonary embolism has been gradually increasing. Older individuals are at an increased risk for pulmonary embolism and anticoagulation-related bleeding events. Typically, heparin and vitamin K antagonists are employed to treat pulmonary embolism; however, these agents present numerous limitations. Hence, novel anticoagulants with improved safety and efficacy profiles are urgently needed.Current Concepts: Direct oral anticoagulants (DOACs), including direct

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44

Merćep, Iveta, Nikolina Friščić, Dominik Strikić, and Željko Reiner. "Advantages and Disadvantages of Inclisiran: A Small Interfering Ribonucleic Acid Molecule Targeting PCSK9—A Narrative Review." Cardiovascular Therapeutics 2022 (February 10, 2022): 1–6. http://dx.doi.org/10.1155/2022/8129513.

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As dyslipidemias remain one of the main risk factors for developing cardiovascular disease, the question of maintaining optimal lipid levels with pharmacotherapy remains a subject of interest worldwide. In contrast to conventional pharmacotherapy, human monoclonal antibodies directed against proprotein convertase subtilisin/kexin type 9 (PSCK9) and small interfering RNA- (siRNA-) based drug targeting PCSK9 represent a new strategy for managing lipid disorders and reducing cardiovascular risk. Inclisiran is a long-acting, synthetic siRNA that targets hepatic production of PCSK9 and consequently

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45

Cerulli, Jennifer, Ben M. Lomaestro, and Margaret Malone. "Update on the Pharmacotherapy of Obesity." Annals of Pharmacotherapy 41, no. 9 (2007): 1505–17. http://dx.doi.org/10.1345/aph.140066.

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Objective: To review recent developments in the pharmacotherapy of obesity, including the agents currently approved for use in the management of obesity and those under development. Data Sources: A MEDLINE search from January 1990 to July 1997 was conducted to identify English literature available on the pharmacotherapy of obesity. The search was supplemented by a review of the bibliographies of identified literature. Study Selection: All controlled and uncontrolled trials were reviewed. When available, double-blind, placebo-controlled trials were used preferentially. Data Extraction: Agents w

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Kumar, Pradeep, and Snehashish Banik. "Pharmacotherapy Options in Rheumatoid Arthritis." Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders 6 (January 2013): CMAMD.S5558. http://dx.doi.org/10.4137/cmamd.s5558.

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Drugs form the mainstay of therapy in rheumatoid arthritis (RA). Five main classes of drugs are currently used: analgesics, non-steroidal anti-inflammatories (NSAIDs), glucocorticoids, nonbiologic and biologic disease-modifying antirheumatic drugs. Current clinical practice guidelines recommend that clinicians start biologic agents if patients have suboptimal response or intolerant to one or two traditional disease modifying agents (DMARDs). Methotrexate, sulfasalazine, leflunomide and hydroxychloroquine are the commonly used DMARDs. Currently, anti-TNF is the commonly used first line biologic

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Kirilochev, O. O., A. R. Umerova, I. P. Dorfman, and S. E. Bataeva. "Safety of pharmacotherapy in the elderly patients with psychiatric diseases." Clinical pharmacology and therapy 29, no. 1 (2020): 80–84. http://dx.doi.org/10.32756/0869-5490-2020-1-80-84.

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Pandi-Perumal, Seithikurippu R., D. Warren Spence, Joris C. Verster, et al. "Pharmacotherapy of Insomnia with Ramelteon: Safety, Efficacy and Clinical Applications." Journal of Central Nervous System Disease 3 (January 2011): JCNSD.S1611. http://dx.doi.org/10.4137/jcnsd.s1611.

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Ramelteon is a tricyclic synthetic analog of melatonin that acts specifically on MT1 and MT2 melatonin receptors. Ramelteon is the first melatonin receptor agonist approved by the Food and Drug Administration (FDA) for the treatment of insomnia characterized by sleep onset difficulties. Ramelteon is both a chronobiotic and a hypnotic that has been shown to promote sleep initiation and maintenance in various preclinical and in clinical trials. The efficacy and safety of ramelteon in patients with chronic insomnia was initially confirmed in short-term placebo-controlled trials. These showed litt

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Bakulin, Igor G., Maria I. Skalinskaya, Igor V. Maev, et al. "Pharmacotherapy of inflammatory bowel diseases: efficacy performance and safety management." Terapevticheskii arkhiv 93, no. 8 (2021): 841–52. http://dx.doi.org/10.26442/00403660.2021.08.200982.

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Treatment of inflammatory bowel diseases IBD (Crohns disease, ulcerative colitis) is aimed at achieving clinical, endoscopic and histological remission, minimizing surgical complications, and ensuring a normal quality of life. However, the use of medical treatment is potentially associated with various adverse events, among which infectious complications, malignant neoplasms, as well as myelotoxicity, hepatotoxicity, skin lesions and others. The risk of side effects depends on the type of drug therapy (5-aminosalicylates, thiopurines, biologicals, etc.), the duration of treatment, the presence

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Нуріманов, К. Р. "Efficacy and Safety of Basic Pharmacotherapy of Chronic Abacterial Prostatitis." Health of Man, no. 1 (April 18, 2019): 40–45. http://dx.doi.org/10.30841/2307-5090.1.2019.172788.

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