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Dissertations / Theses on the topic 'PHAST Library'

Author: Grafiati

Published: 14 March 2023

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1

Peccerillo, Biagio. "PHAST Library - A Productive Solution to Program Heterogeneity." Doctoral thesis, Università di Siena, 2020. http://hdl.handle.net/11365/1107894.

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Oggigiorno, le architetture parallele sono ovunque: computer desktop, dispositivi mobile, workstation ad alte prestazioni e server sono solo alcuni esempi. Oltre ai classici multi-core, anche GPU, FPGA, TPU e altri dispositivi vengono utilizzati in un ampio spettro di applicazioni. In questa era post-PC, i programmatori devono necessariamente sfruttare l'eterogeneità per utilizzare pienamente l'hardware e raggiungere prestazioni senza precedenti. Scrivere codice eterogeneo può essere difficile: ogni dispositivo può avere i suoi linguaggi, i suoi framework e i suoi stili di programmazione. Per

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2

Harris, Jasmine K. "Bioconjugation of aminated DNA as a method of rapid polymer library generation for Corona Phase Molecular Recognition." Thesis, Massachusetts Institute of Technology, 2018. http://hdl.handle.net/1721.1/119063.

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Thesis: S.B., Massachusetts Institute of Technology, Department of Materials Science and Engineering, 2018.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (page 39).<br>An experimental study was performed to determine the effects on Corona Phase Molecular Recognition (CoMoRe) of bioconjugating a host of small molecules to DNA wrapped single-walled carbon nanotubes. In addition, the study observed the effects of the DNA sequence length on the subsequent effectiveness of the small molecules to alter the corona phase. The conjugation of small molecules was shown t

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3

Hwang, Sung Hee. "I. Combinatorial solid-phase synthesis of isoxasolinopyrroles. II. OBOC small molecule combinatorial library encoded by halogenated mass-tags /." For electronic version search Digital dissertations database. Restricted to UC campuses. Access is free to UC campus dissertations, 2004. http://uclibs.org/PID/11984.

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4

Yamakawa, Tatsuya. "Screening of human cDNA library reveals two differentiation-related genes, HHEX and HLX, as promoters of early phase reprogramming toward pluripotency." Kyoto University, 2016. http://hdl.handle.net/2433/217142.

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5

Ruda, Marcus. "Design and synthesis of steroid mimetic libraries using solid phase techniques /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-049-4/.

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6

Bandmann, Nina. "Rational and combinatorial genetic engineering approaches for improved recombinant protein production and purification." Doctoral thesis, Stockholm : Bioteknologi, Kungliga Tekniska högskolan, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-4318.

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7

Huang, Adela Ya-Ting. "Advancing dendrimer synthesis : solid-phase and self-assembly approach." Thesis, Aix-Marseille, 2017. http://www.theses.fr/2017AIXM0146.

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Les dendrimères sont très prometteurs du fait de leur structure unique et de leur multivalence. Cependant, leur synthèse souffre de problèmes de défauts de structure et de présence de produits secondaires très similaires. Des approches synthétiques alternatives sont donc fortement désirées. L'objectif de ma thèse consiste à explorer la synthèse sur support solide et l’approche d'autoassemblage pour la préparation de dendrimères.La première partie de ma thèse se concentre sur la synthèse de dendrimères en phase solide. Nous avons tout d'abord développé une méthode de synthèse pour les dendrimèr

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8

Chen, Xingguo Ronald. "Pin1 Catalytic and WW Domain Ligands." Diss., Virginia Tech, 2011. http://hdl.handle.net/10919/37824.

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Pin1 is a peptidyl prolyl isomerase (PPIase) enzyme with two domains, the catalytic domain and the WW domain. Both domains specifically bind pSer/pThrâ Pro motifs. Pin1 plays an important role in regulating the cell cycle, and it is involved in many diseases, such as cancer, HIV-1, Alzheimerâ s disease, asthma, hepatitis B, and rheumatoid arthritis. Pin1 is a very promising target for new drug development. Three stereoisomers: (R,S)-, (S,R)- and (S,S)-Acâ pSerâ Î¨[(Z)CH=C]â Pipâ 2-(2-naphthyl)ethylamine were synthesized as inhibitors binding to the Pin1 catalytic domain. The (R,S)- and

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9

Nilsson, Jonas. "Design, Synthesis and Characterization of Small Molecule Inhibitors and Small Molecule : Peptide Conjugates as Protein Actors." Doctoral thesis, Linköpings universitet, Organisk Kemi, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-3943.

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This thesis describes different aspects of protein interactions. Initially the function of peptides and their conjugates with small molecule inhibitors on the surface of Human Carbonic Anhydrase isoenzyme II (HCAII) is evaluated. The affinities for HCAII of the flexible, synthetic helix-loop-helix motif conjugated with a series of spacered inhibitors were measured by fluorescence spectroscopy and found in the best cases to be in the low nM range. Dissociation constants show considerable dependence on linker length and vary from 3000 nM for the shortest spacer to 40 nM for the longest with a mi

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10

Subramaniam, Raja. "Simplified Routines for Sample Preparation and Analysis of Chemical Warfare Agent Degradation Products." Doctoral thesis, Umeå universitet, Kemiska institutionen, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-54639.

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The thesis describes the development of new and improved methods for analyzing degradation markers from organophosphorus Chemical Warfare Agents (CWAs). Paper I and II describes an innovative and significantly improved method for the enrichment, derivatization (trimethysilylation) and GC-MS analysis of a broad range of organophosphorus CWAs degradation markers, namely the alkylphosphonic acids and a zwitterionic compound. That was achieved using solid phase disc extraction in combination with solid phase derivatization. The new method overcomes most limitations observed with existing technique

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11

Aftab, Obaid. "Towards High-Throughput Phenotypic and Systemic Profiling of in vitro Growing Cell Populations using Label-Free Microscopy and Spectroscopy : Applications in Cancer Pharmacology." Doctoral thesis, Uppsala universitet, Cancerfarmakologi och beräkningsmedicin, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-234565.

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Modern techniques like automated microscopy and spectroscopy now make it possible to study quantitatively, across multiple phenotypic and molecular parameters, how cell populations are affected by different treatments and/or environmental disturbances. As the technology development at the instrument level often is ahead of the data analytical tools and the scientific questions, there is a large and growing need for computational algorithms enabling desired data analysis. These algorithms must have capacity to extract and process quantitative dynamic information about how the cell population is

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12

Leslie, Susan Elder. "An examination of the information behaviour of new entrepreneurs in the start-up phase of a business submitted to the School of Information Management, Victoria University of Wellington in partial fulfilment of the requirements for the degree of Master of Library and Information Studies /." ResearchArchive@Victoria e-Thesis, 2009. http://hdl.handle.net/10063/1271.

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13

Joo, Sang Hoon. "Synthesis and screening of support-bound combinatorial cyclic peptide and free C-terminal peptide libraries." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1195561420.

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14

Cheng-yi, Wu, та 吳正一. "Liquid-Phase Combinatorial Synthesis of Guanidine; Benzimidazole; β—Carbolines and Diketopiperazine Heterocyclic Library". Thesis, 2002. http://ndltd.ncl.edu.tw/handle/72297976192956003789.

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碩士<br>國立東華大學<br>化學系<br>90<br>Abstract Combinatorial chemistry has become an important part of the discovery and optimization process for novel drugs, affinity ligands, and catalysts. The technology has been applied in both academic and industrial institutions to provide a number of unique approaches to satisfy the ever-growing need for new chemical entities with proven utility. This thesis use Liquid Phase Combinatorial Chemistry for synthesis of four kinds Heterocyclic Libraries. 1.Guanidine Heterocyclic Library 2.Benzimidazole Heterocyclic Library 3.1,2,3,4-Tetrahydro-β —Ca

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15

陳志豪. "Studies of the Sulfone Linker in Solid-Phase Organic Synthesis and Compound Library." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/48340940668922775732.

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碩士<br>國立交通大學<br>應用化學系所<br>92<br>Abstract Using sulfinate functionalized resin as a solid support, we have developed a new cleavage reagent, Al(CH3)3, and successfully synthesized a small library of compounds with structures like compound Ⅰ and Ⅱ. First of all, benzene sulfinic acid sodium salt was used as starting material in liquid phase experiment. Through six reaction steps, we obtained compound 7 in about 15% total yield, which demonstrated that compounds similar to Ⅰ and Ⅱ can be synthesized. Then, we successfully prepared resin 8 which has sulfone linker. Using resin 8 as solid support

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16

Pang, Cheng-Tse, and 潘承澤. "Synthesis of aminosaccharides as a core compound for constructing a solution-phase derived library." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/63633126174632025710.

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碩士<br>國立清華大學<br>生醫工程與環境科學系<br>97<br>The aim of this research is to generate the monosaccharide, disaccharide, trisaccharide and tetrasaccharide of galactose bearing amine groups which would be used for coupling with numerous carboxylic acids. The coupled products in the mixture was directly submitted to a screen assay for their cytotoxicities against the cancer cell lines. Monosaccharide Gal-O-(CH2)3CH2N3, disaccharide Gal(1→6)Gal, trisaccharide and tetrasaccharide have been successfully prepared. Glycosylation of the 2-(azidomethyl)-6- ((trichloromethylamino)methoxy)tetrahydro-2H-pyra

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17

林淑芬. "（（Ⅰ）Microwave-Assisted Liquid Phase Parallel Synthesis of Bis(benzimidazoles) Library which Has Anticancer Activity Analogue to UK-1（Ⅱ）Microwave-Assisted Liquid Phase Syntehsie of Quinoxalinone Library via Ugi Four-Component Condensation（Ⅲ）Solut." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/12025886230606867834.

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18

Wu, Songping. "Phase noise effects on OFDM analysis and mitigation /." Thesis, 2004. http://library1.njit.edu/etd/fromwebvoyage.cfm?id=njit-etd2004-102.

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19

Liao, Kuo-Yen, and 廖國延. "Synthesis of amino glycosphingosine analog as a core compound for constructing a solution-phase derived library." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/52751453733138895897.

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20

Chang, Kai-Hsiang, and 張凱翔. "Synthesis of amino sphingosine analogue as a core compound for contructing a solution-phase derived library." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/05661486095692930879.

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碩士<br>國立清華大學<br>生醫工程與環境科學系<br>97<br>本論文之研究目的為合成神經醯胺醇之類似物，作為核心化合物與各種類之酸耦合形成醯胺鍵後，以之建立分子庫篩選實驗。以絲胺酸作為起始物，經五步合成獲得Garner’s aldehyde，而後以Wittig reaction、Sharpless dihydroxylation。再將裸露之雙醇基以Benzyl基保護，接著除去Boc及acetonide保護基，形成神經醯胺醇之結構((2S,3S,4R)-2-amino-3,4-bis(benzyloxy)heptadecan-1-ol)。以TfN3將胺基轉換成azido基後，欲將官能基轉換(1°OH→NH2)時，以triflate作為離去基，卻無法得到目標物，反而形成五員環之Jaspin B類似物。而後改用tosylate作為離去基時，以吡啶及二氯甲烷(體積比為一比一)作為溶劑下成功地將醇基轉換為tosylate。再以疊氮化鋰將tosylate取代為azido基，最後嘗試一系列之氫化條件，欲將兩個azido基及benzyl基一併去除，但無法達成，benzyl基無法完全還原。故改用以三氯化硼的條件，欲先除去兩個benzyl基，在此條件下，不僅成功地還原了兩benzyl基，另外亦還原其一azido基，總計十三步合成，產率4%。未來此化合物將與各式羧酸經由活化條件來進行耦合

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21

Tong, Xiaomei. "Detection of vapor phase mercury species by laser fluorescence methods." Thesis, 2001. http://library1.njit.edu/etd/fromwebvoyage.cfm?id=njit-etd2001-105.

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22

Mandelbaum, Idan. "Phase tunability in a conductor backed coplanar waveguide patch antenna." Thesis, 2000. http://library1.njit.edu/etd/fromwebvoyage.cfm?id=njit-etd2000-005.

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23

Shen, Zheng. "Phase transfer in a collision between a droplet and solid spheres." Thesis, 2008. http://library1.njit.edu/etd/fromwebvoyage.cfm?id=njit-etd2008-024.

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24

Gundel, Adnan. "Low jitter phase-locked loop clock synthesis with wide locking range." Thesis, 2007. http://library1.njit.edu/etd/fromwebvoyage.cfm?id=njit-etd2007-046.

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25

Rafique, Qureshi Muhammad Mushahid. "Flow characteristics and phase interactions of evaporating sprays in gas-solid suspensions." Thesis, 2007. http://library1.njit.edu/etd/fromwebvoyage.cfm?id=njit-etd2007-027.

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26

Zhang, Jing. "Phase transitions of poly (l-lactic acid) in bulk and in solution." Thesis, 2006. http://library1.njit.edu/etd/fromwebvoyage.cfm?id=njit-etd2006-045.

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27

Arturo, Steven G. "Fluid-phase thermodynamics from molecular-level properties and interactions based in quantum theory." Thesis, 2005. http://library1.njit.edu/etd/fromwebvoyage.cfm?id=njit-etd2005-062.

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28

Jiang, Lijun. "A micromachined thermo-optical light modulator based on semiconductor-to-metal phase transition." Thesis, 2004. http://library1.njit.edu/etd/fromwebvoyage.cfm?id=njit-etd2004-025.

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Thesis (Ph.D) -- New Jersey Institute of Technology, Committee for the Interdisciplinary Program in Materials Science and Engineering, 2004.<br>Includes bibliographical references. Also available via the World Wide Web.

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29

Abbassi, Younes. "Determination of phase composition of sputtered tantalum on steel substrates by resistivity measurements." Thesis, 2002. http://library1.njit.edu/etd/fromwebvoyage.cfm?id=njit-etd2002-026.

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30

Zimu, Acquinatta Nomusa. "Assessment of information literacy skills of first-year students at Mangosuthu Technikon at a pre-library orientation and instruction phase." Thesis, 2005. http://hdl.handle.net/10413/1972.

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This study assessed the information literacy (IL) skills of first-year students at Mangosuthu Technikon (MANTEC) at a pre-library orientation and instruction phase. What is evident is that students do, to a greater or lesser degree, display inadequate levels of IL skills. What is not so evident is the extent and nature of these inadequacies. The purpose of the study was to establish the level of these inadequacies. Background information concerning the MANTEC library orientation and instruction programme and the Eastern Seaboard Association of Libraries (esAL) User Education Pilot Project stud

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31

Ermoline, Alexandre. "Experimental technique for studying high-temperature phase equilibria in reactive molten metal based systems." Thesis, 2005. http://library1.njit.edu/etd/fromwebvoyage.cfm?id=njit-etd2005-023.

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32

Trunov, Mikhaylo Aleksiyovych. "Effect of polymorphic phase transformations within an alumina layer on the ignition of aluminum particles." Thesis, 2006. http://library1.njit.edu/etd/fromwebvoyage.cfm?id=njit-etd2006-086.

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33

Gautam, Shalini. "Optimization of sequential purification of beta-glucosidase from tricoderma reesei in aqueous two-phase system." Thesis, 2005. http://library1.njit.edu/etd/fromwebvoyage.cfm?id=njit-etd2005-066.

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34

Lee, Sok-kyu. "Phase-locked loop, delay-locked loop, and linear decorrelating detector for asynchronous multirate DS-CDMA system." Thesis, 2001. http://library1.njit.edu/etd/fromwebvoyage.cfm?id=njit-etd2001-043.

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35

Chen, Chia-Jung, and 陳珈融. "Construction of the solution-phase derived nucleoside library and screening of its cytotoxicity against HSV1-tk transfected murine fibrosarcoma cells." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/08706433629818907754.

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36

Lai, Jin-Ji, and 賴俊吉. "(Ⅰ) Liquid Phase Combinatorial Prallel Synthesis of Bis(benzimidazole)、beta-Carboline、Benzodiazepine and Quinoxalinone Library (Ⅱ) Synthesis of Andrographolide Analogues." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/47945831159749339186.

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37

Shin, Sanghoon. "Theory and design of mixed lumped-distributed cross-coupled filters with applications to linear phase shifter and tunable filters." Thesis, 2002. http://library1.njit.edu/etd/fromwebvoyage.cfm?id=njit-etd2002-053.

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38

Santos, David Jorge Pires dos. "Identification of metabolites by liquid chromatography quadrupole time-of-flight mass spectrometric technique." Master's thesis, 2016. http://hdl.handle.net/10451/34605.

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Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2016<br>Analytical methods based on mass spectrometry and coupled to a chromatographic separation technique such as HPLC or GC, are crucial for investigating human metabolome, UPLC coupled with ESI-MS is a recent methodology representing an effective tool to separate and analyze molecules. The mains focus of this experimental work was to elucidate the influence of HILIC and Reversed-Phase chromatography on the analysis of compounds through ESI-MS. One additional aim was also to collec

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39

Tsai, Cheng-Hsun, and 蔡政勳. "(Ⅰ) Microwave-Assisted Fluoros-Phase One-Pot Synthesis of Benzimidazole Library (Ⅱ) Polymer Support Synthesis of Imidazoquinoxalinone Derivatives (Ⅲ) Application of Intramolecular Diels-Alder Reaction in the Synthesis of [6,5,6,5,6] Ring Indole Alkaloid." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/24188342254872145226.

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40

Dufour-Gallant, Julien. "Synthèse en phase solide de pyrrolo[3,2-e][1,4]diazépin-2-ones modulateurs du système urotensinergétique." Thèse, 2016. http://hdl.handle.net/1866/18417.

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Les pyrrolodiazépinones ont des activités biologiques intéressantes sur différents récepteurs biologiques, ce qui en font une cible de choix pour développer de nouvelles petites molécules biologiquement actives. Une méthodologie en solution a été développée pour synthétiser des pyrrolo[3,2-e][1,4]diazépin-2-ones, qui utilise la réaction de Pictet-Spengler pour former le cycle diazépinone, comme réaction clé. Il a été démontré que le pyrrolo[3,2-e][1,4]diazépin-2-one mime un tour-γ inverse par l’analyse de cristaux par rayon X. Cette méthodologie a été transposée sur trois types de support, soi

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