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Journal articles on the topic 'PHD-2'

Author: Grafiati

Published: 24 April 2022

Last updated: 30 July 2025

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1

Li, Ningjun, Fan Yi, Christina M. Sundy, et al. "Expression and actions of HIF prolyl-4-hydroxylase in the rat kidneys." American Journal of Physiology-Renal Physiology 292, no. 1 (2007): F207—F216. http://dx.doi.org/10.1152/ajprenal.00457.2005.

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Hypoxia inducible factor (HIF) prolyl-4-hydroxylase domain-containing proteins (PHDs) promote the degradation of HIF-1α. Because HIF-1α is highly expressed in the renal medulla and HIF-1α-targeted genes such as nitric oxide synthase, cyclooxygenase, and heme oxygenase are important in the regulation of renal medullary function, we hypothesized that PHD regulates HIF-1α levels in the renal medulla and, thereby, participates in the control of renal Na+ excretion. Using real-time RT-PCR, Western blot, and immunohistochemical analyses, we have demonstrated that all three isoforms of PHD, PHD1, PHD

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Saito, Atsushi, Tokuro Iwabuchi, and Shigeaki Harayama. "A Novel Phenanthrene Dioxygenase fromNocardioides sp. Strain KP7: Expression inEscherichia coli." Journal of Bacteriology 182, no. 8 (2000): 2134–41. http://dx.doi.org/10.1128/jb.182.8.2134-2141.2000.

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ABSTRACT Nocardioides sp. strain KP7 grows on phenanthrene but not on naphthalene. This organism degrades phenanthrene via 1-hydroxy-2-naphthoate, o-phthalate, and protocatechuate. The genes responsible for the degradation of phenanthrene too-phthalate (phd) were found by Southern hybridization to reside on the chromosome. A 10.6-kb DNA fragment containing eight phd genes was cloned and sequenced. ThephdA, phdB, phdC, andphdD genes, which encode the α and β subunits of the oxygenase component, a ferredoxin, and a ferredoxin reductase, respectively, of phenanthrene dioxygenase were identified.

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Miyata, Toshio, Shunya Takizawa, and Charles van Ypersele de Strihou. "Hypoxia. 1. Intracellular sensors for oxygen and oxidative stress: novel therapeutic targets." American Journal of Physiology-Cell Physiology 300, no. 2 (2011): C226—C231. http://dx.doi.org/10.1152/ajpcell.00430.2010.

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A variety of human disorders, e.g., ischemic heart disease, stroke, kidney disease, eventually share the deleterious consequences of a common, hypoxic and oxidative stress pathway. In this review, we utilize recent information on the cellular defense mechanisms against hypoxia and oxidative stress with the hope to propose new therapeutic tools. The hypoxia-inducible factor (HIF) is a key player as it activates a broad range of genes protecting cells against hypoxia. Its level is determined by its degradation rate by intracellular oxygen sensors prolyl hydroxylases (PHDs). There are three diffe

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Ornelas, Alfredo, Jacob Countess, Nichole Welch, Ian Cartwright, and Sean Colgan. "PROTEOLYSIS TARGETING CHIMERAS (PROTACS) AS ATTRACTIVE THERAPEUTICS IN IBD THROUGH THE REGULATION OF HYPOXIA-INDUCIBLE FACTORS." Inflammatory Bowel Diseases 30, Supplement_1 (2024): S61. http://dx.doi.org/10.1093/ibd/izae020.127.

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Abstract Inflammatory bowel disease (IBD) represents a group of chronic mucosal inflammatory disorders, including Crohn’s disease (CD) and ulcerative colitis (UC). Many IBD patients have limited therapeutic options. Accumulating literature has implicated a prominent role for O2 metabolism and hypoxia in innate immunity of healthy intestinal tissue (“physiologic hypoxia”) and shifts associated with active inflammation (“inflammatory hypoxia”). Reduction of oxygen levels triggers the temporal stabilization of the transcription factors hypoxia-inducible factors HIF1a and HIF2a, which are essentia

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Xing, Weirong, Destiney Larkin, Sheila Pourteymoor, et al. "Lack of Skeletal Effects in Mice with Targeted Disruptionof Prolyl Hydroxylase Domain 1 (Phd1) Gene Expressed in Chondrocytes." Life 13, no. 1 (2022): 106. http://dx.doi.org/10.3390/life13010106.

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The critical importance of hypoxia-inducible factor (HIF)s in the regulation of endochondral bone formation is now well established. HIF protein levels are closely regulated by the prolyl hydroxylase domain-containing protein (PHD) mediated ubiquitin-proteasomal degradation pathway. Of the three PHD family members expressed in bone, we previously showed that mice with conditional disruption of the Phd2 gene in chondrocytes led to a massive increase in the trabecular bone mass of the long bones. By contrast, loss of Phd3 expression in chondrocytes had no skeletal effects. To investigate the rol

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Boulahbel, Houda, Raúl V. Durán, and Eyal Gottlieb. "Prolyl hydroxylases as regulators of cell metabolism." Biochemical Society Transactions 37, no. 1 (2009): 291–94. http://dx.doi.org/10.1042/bst0370291.

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Cellular response to oxygen depletion is mediated by HIF (hypoxia-inducible factor). HIF is a heterodimer consisting of a constitutively expressed subunit (HIFβ) and an oxygen-regulated subunit (HIFα). HIFα stability is regulated by prolyl hydroxylation by PHD (prolyl hydroxylase domain-containing protein) family members. PHD activity depends on the availability of molecular oxygen, making PHDs the oxygen-sensing system in animal cells. However, PHDs have recently been shown to respond to stimuli other than oxygen, such as 2-oxoglutarate (α-ketoglutarate), succinate or fumarate, as illustrated

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Fleetwood, Janet. "Opinion #2: Janet Fleetwood, PhD." Pain Medicine 3, no. 1 (2002): 74–76. http://dx.doi.org/10.1046/j.1526-4637.2002.02006_3.x.

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8

Teijlingen, Edwin van, Bibha Simkhada, Pramod Regmi, Padam Simkhada, Vanora Hundley, and Krishna C. Poudel. "Reflections on Variations in PhD Viva Regulations: “And the Options Are …”." Journal of Education and Research 12, no. 2 (2022): 61–74. http://dx.doi.org/10.51474/jer.v12i2.624.

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Getting a PhD is the highest possible education qualification which only a small proportion of all students achieve. As a consequence, examining PhD research in the form of a doctoral thesis is specialist work. This paper highlights the different options that are available for PhD examiners. There are four general options: (1) pass, (2) rewrite and resubmit; (3) lower degree, with or without resubmission; and (4) fail the PhD. However, from our experience, of both being examined for our own PhDs and examining others at a range of different universities, we have noted a considerable variety in

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9

Berg, Richard E. "Resource Letter PhD-2: Physics Demonstrations." American Journal of Physics 80, no. 3 (2012): 181–91. http://dx.doi.org/10.1119/1.3660659.

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10

Naughton, Felix. "Stage 2: The ‘PhD route’ experience." Health Psychology Update 20, no. 3 (2011): 16–19. http://dx.doi.org/10.53841/bpshpu.2011.20.3.16.

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Chen, Jianji, John Horton, Cari Sagum, Jujun Zhou, Xiaodong Cheng, and Mark T. Bedford. "Histone H3 N-terminal mimicry drives a novel network of methyl-effector interactions." Biochemical Journal 478, no. 10 (2021): 1943–58. http://dx.doi.org/10.1042/bcj20210203.

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The reader ability of PHD fingers is largely limited to the recognition of the histone H3 N-terminal tail. Distinct subsets of PHDs bind either H3K4me3 (a transcriptional activator mark) or H3K4me0 (a transcriptional repressor state). Structural studies have identified common features among the different H3K4me3 effector PHDs, including (1) removal of the initiator methionine residue of H3 to prevent steric interference, (2) a groove where arginine-2 binds, and (3) an aromatic cage that engages methylated lysine-4. We hypothesize that some PHDs might have the ability to engage with non-histone

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Poloznikov, Andrey A., Sergey V. Nikulin, Dmitry M. Hushpulian, et al. "Structure–Activity Relationships and Transcriptomic Analysis of Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors." Antioxidants 11, no. 2 (2022): 220. http://dx.doi.org/10.3390/antiox11020220.

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To evaluate the differences in action of commercially available 2-oxoglutarate mimetics and “branched-tail” oxyquinoline inhibitors of hypoxia-inducible factor prolyl hydroxylase (HIF PHD), the inhibitors’ IC50 values in the activation of HIF1 ODD-luciferase reporter were selected for comparative transcriptomics. Structure–activity relationship and computer modeling for the oxyquinoline series of inhibitors led to the identification of novel inhibitors, which were an order of magnitude more active in the reporter assay than roxadustat and vadadustat. Unexpectedly, 2-methyl-substitution in the

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Шамшиев, Ж.А, З.З Джамалов та Н.Х. Садуллаева. "ИСТИҚБОЛЛИ ТЕХНОЛОГИЯЛАР АСОСИДА УЗУМ ХОМ-АШЁСИНИ САҚЛАШ УСУЛЛАРИ". Role of agriculture and medicine in science va O'zbekiston Agrar fani xabarnomasi Maxsus son, № 1/1(19) 2025 (2025): 232–36. https://doi.org/10.5281/zenodo.15000476.

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<strong>УДК 634.86</strong><strong> </strong> <strong>ИСТИҚБОЛЛИ ТЕХНОЛОГИЯЛАР АСОСИДА УЗУМ ХОМ-АШЁСИНИ САҚЛАШ УСУЛЛАРИ</strong> <strong>Шамшиев Ж.А.<sup>1</sup>, Джамалов З.З.<sup>2</sup>, Садуллаева Н.Х.<sup>3</sup></strong> <sup>1</sup>Жиззах политехника институти, қ.х.ф.ф.д. (PhD) <sup>2</sup>Жиззах политехника институти, т.ф.ф.д. (PhD) <sup>3</sup>Жиззах политехника институти, магистр z.djamalov@mail.ru   <strong>СПОСОБЫ ХРАНЕНИЯ ВИНОГРАДНОГО СЫРЬЯ ПО </strong><strong> </strong><strong>ПЕРСПЕКТИВНЫМ ТЕХНОЛОГИЯМ</strong> <strong>Шамшиев Дж.А.<sup>1</sup>, Джамалов З.З.<sup>2</sup

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14

Rich, Ben A. "Opinion #2: Ben A. Rich, JD, PhD." Pain Medicine 5, no. 2 (2004): 207–9. http://dx.doi.org/10.1111/j.1526-4637.2004.4030_2.x.

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Dalai, Sudeb C., Jennifer N. Dines, Thomas M. Snyder, et al. "144. Clinical Validation and Performance of a T-cell Immunosequencing Assay to Identify Past SARS-CoV-2 Infection." Open Forum Infectious Diseases 8, Supplement_1 (2021): S87. http://dx.doi.org/10.1093/ofid/ofab466.144.

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Abstract Background Our understanding of the SARS-CoV-2 immune response has critical gaps that are inadequately addressed with available tools. We report the clinical performance of T-Detect COVID, the first T-cell assay to identify prior SARS-CoV-2 infection using T-cell receptor (TCR) sequencing and repertoire profiling from whole blood samples. Methods The T-Detect COVID assay combines high-throughput immunosequencing of the TCRß gene from blood samples with a statistical classifier demonstrating 99.8% specificity for identifying prior SARS-CoV-2 infection. The assay was employed in several

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Caddick, Nick, and Hamish Cox. "Managing transitions Part 2: From MSc to PhD student." Sport & Exercise Psychology Review 8, no. 2 (2012): 75–79. http://dx.doi.org/10.53841/bpssepr.2012.8.2.75.

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In this article, we provide two contrasting personal reflections on the transition from the same MSc course to a self-funded and a grant-funded PhD. We begin with Nick’s reflexive account of the transition to a self-funded PhD where we outline the challenges involved in becoming a researcher. We then detail Hamish’s experience of securing a funded PhD and discuss the skills needed to be successful in research, alongside the value of self-reflection. Making the transition from MSc to PhD can be a challenging and uncertain time. We hope this article will provide a useful resource for students co

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Snyder, Thomas M., Rachel M. Gittelman, Mark Klinger, et al. "126. Magnitude and Dynamics of the T-Cell Response to SARS-CoV-2 Infection and Vaccination." Open Forum Infectious Diseases 8, Supplement_1 (2021): S77. http://dx.doi.org/10.1093/ofid/ofab466.126.

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Abstract Background T cells are central to the early identification and clearance of viral infections and support antibody generation by B cells, making them desirable for assessing the immune response to SARS-CoV-2 infection and vaccines. We combined 2 high-throughput immune profiling methods to create a quantitative picture of the SARS-CoV-2 T-cell response that is highly sensitive, durable, diagnostic, and discriminatory between natural infection and vaccination. Methods We deeply characterized 116 convalescent COVID-19 subjects by experimentally mapping CD8 and CD4 T-cell responses via ant

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May, Meiling R., John T. Bettridge, and Stephen Desiderio. "Binding and allosteric transmission of histone H3 Lys-4 trimethylation to the recombinase RAG-1 are separable functions of the RAG-2 plant homeodomain finger." Journal of Biological Chemistry 295, no. 27 (2020): 9052–60. http://dx.doi.org/10.1074/jbc.ra120.014382.

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V(D)J recombination is initiated by the recombination-activating gene protein (RAG) recombinase, consisting of RAG-1 and RAG-2 subunits. The susceptibility of gene segments to cleavage by RAG is associated with gene transcription and with epigenetic marks characteristic of active chromatin, including histone H3 trimethylated at lysine 4 (H3K4me3). Binding of H3K4me3 by a plant homeodomain (PHD) in RAG-2 induces conformational changes in RAG-1, allosterically stimulating substrate binding and catalysis. To better understand the path of allostery from the RAG-2 PHD finger to RAG-1, here we emplo

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Andrade, Viviane M., Aaron Christensen-Quick, Joseph Agnes, et al. "578. INO-4800 DNA Vaccine Induces Neutralizing Antibodies and T cell Activity Against Global SARS-CoV-2 Variants." Open Forum Infectious Diseases 8, Supplement_1 (2021): S390—S391. http://dx.doi.org/10.1093/ofid/ofab466.776.

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Abstract Background Global surveillance has identified emerging SARS-CoV-2 variants of concern (VOC) associated with increased transmissibility, disease severity, and resistance to neutralization by current vaccines under emergency use authorization (EUA). Here we assessed cross-immune responses of INO-4800 vaccinated subjects against SARS-CoV-2 VOCs. Methods We used a SARS-CoV-2 IgG ELISA and a pseudo neutralization assay to assess humoral responses, and an IFNγ ELISpot to measure cellular responses against SARS-CoV-2 VOC in subjects immunized with the DNA vaccine, INO-4800. Results IgG bindi

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Jerger, James, and Frank Musiek. "Report of the Consensus Conference on the Diagnosis of Auditory Processing Disorders in School-Aged Children." Journal of the American Academy of Audiology 11, no. 09 (2000): 467–74. http://dx.doi.org/10.1055/s-0042-1748136.

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BACKGROUNDA group of 14 senior scientists and clinicians met at the Callier Center in Dallas over the 2–day period, April 27–28, 2000, in an attempt to reach a consensus on the problem of diagnosing auditory processing disorders in school-aged children. The conference was organized by James Jerger and Frank Musiek. The following individuals participated:Sharon Abel, PhD, University of Toronto, Toronto, ONJane Baran, PhD, University of Massachusetts, Amherst, MAAnthony Cacace, PhD, Albany Medical College, Albany, NYGail Chermak, PhD ‡, Washington State University, Pullman, WASusan Dalebout, PhD

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Tebas, Pablo, Joseph Agnes, Mary Giffear, et al. "571. Safety and Immunogenicity of INO-4800, a COVID-19 DNA Vaccine as a Primary Series and Booster." Open Forum Infectious Diseases 8, Supplement_1 (2021): S387—S388. http://dx.doi.org/10.1093/ofid/ofab466.769.

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Abstract Background DNA vaccines are safe, tolerable, elicit humoral and cellular responses, allow for repeated dosing over time, are thermostable at room temperature, and are easy to manufacture. We present a compilation of Phase 1 and Phase 2 data of Inovio’s US COVID-19 DNA Vaccine (INO-4800) targeting the full-length Spike antigen of SARS-CoV-2. A South Korean Phase 2 study is ongoing. Methods Participants in the open-label Phase 1 trial received 0.5 mg, 1.0 mg or 2.0 mg intradermally (ID) followed by electroporation (EP) at Days 0 and 28. An optional booster dose was administered &gt;

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Bahall, Mandreker U., and George Legall. "Pre-hospital care in stable patients with acute coronary syndrome: Factors and predictors of pre-hospital delays in a tertiary public health institute." International Journal Of Community Medicine And Public Health 5, no. 1 (2017): 12. http://dx.doi.org/10.18203/2394-6040.ijcmph20175515.

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Background: Incidences of pre-hospital delays (PHDs) remain high and affect the outcomes in acute coronary syndrome (ACS) patients. This study explored the factors associated with, and the predictors of PHD in ACS patients. Methods: Data were collected through interviews and the examination of the hospital records of 299 ACS patients admitted to a hospital between 1 December 2014 and 28 February 2015. Results: The patients were primarily female, and their mean age was 60.9±12.09 years. The mean PHD was 7.5±6.6 hours; this comprised mean delay from symptoms onset to departure, mean travel time

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Navarro, Gabriella Y., Elizabeth Ashley Stinson, Ryan Sullivan, and Krista Lisdahl. "23 The Impact of Parental History of Substance Use on Preadolescent Rewarding Processing in the ABCD Study." Journal of the International Neuropsychological Society 29, s1 (2023): 813–14. http://dx.doi.org/10.1017/s1355617723010093.

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Objective:Parental history (PH) of problematic substance use has been identified as a risk factor for adolescent substance use, which can lead to increased use in adulthood. Researchers hypothesize that individuals with PH exhibit premorbid differences in their reward processing, increasing their likelihood of engaging in reward-driven behavior. Studies have shown that preadolescents with PH have greater activation in their putamen and nucleus accumbens (NA); however, most research has only investigated PH of alcohol use (PHA), not PH of drug use (PHD). Additionally, limited research has asses

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Grabber, John H., José Luiz C. S. Dias, and Mark J. Renz. "Establishment of Alfalfa Intercropped under Corn in Response to Varying Rates of Prohexadione with or without Fungicide Plus Insecticide." Agronomy 13, no. 11 (2023): 2823. http://dx.doi.org/10.3390/agronomy13112823.

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Establishment of interseeded alfalfa (Medicago sativa L.) under corn (Zea mays L.) silage is enhanced with foliar applications of prohexadione (PHD) followed by fungicide plus insecticide (FI), but the lowest effective rates must be determined. We evaluated stand characteristics of alfalfa interseeded into corn at Arlington, Wisconsin, USA in response to PHD applied at 0 to 0.423 kg a.e. ha−1 followed two weeks later with FI (none vs. 0.147 kg a.i. ha−1 fluxapyroxad-pyraclostrobin plus 0.018 kg a.i. ha−1 lambda-cyhalothrin). Application of PHD reduced etiolation, while FI treatment increased p

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Couvelard, Anne, Lydia Deschamps, Vinciane Rebours, et al. "Overexpression of the Oxygen Sensors PHD-1, PHD-2, PHD-3, and FIH Is Associated with Tumor Aggressiveness in Pancreatic Endocrine Tumors." Clinical Cancer Research 14, no. 20 (2008): 6634–39. http://dx.doi.org/10.1158/1078-0432.ccr-07-5258.

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Ross, Timothy, Julie Mah, Jeff Biggar, Austin Zwick, and Ewa Modlinska. "Student Needs, Employment Realities, and PhD Program Design in Canada: The Case of Planning PhD Programs." Canadian Journal of Higher Education 48, no. 3 (2018): 82–97. http://dx.doi.org/10.47678/cjhe.v48i3.188161.

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PhD graduates in Canada routinely find themselves considering employment outside academia. This paper explores PhD program design in relation to PhD students’ employment realities through a case study of Canadian planning PhD programs. Two questions guided the study: (1) How could planning PhD programs be redesigned to prepare students for a wider variety of career options post-graduation? And (2) What are some of the institutional challenges hindering PhD program reform? To engage these questions, we surveyed planning PhD students and program directors, gathered email input from planning prac

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Ross, Timothy, Julie Mah, Jeff Biggar, Austin Zwick, and Ewa Modlinska. "Student Needs, Employment Realities, and PhD Program Design in Canada: The Case of Planning PhD Programs." Articles 48, no. 3 (2019): 82–97. http://dx.doi.org/10.7202/1057130ar.

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PhD graduates in Canada routinely find themselves considering employment outside academia. This paper explores PhD program design in relation to PhD students’ employment realities through a case study of Canadian planning PhD programs. Two questions guided the study: (1) How could planning PhD programs be redesigned to prepare students for a wider variety of career options post-graduation? And (2) What are some of the institutional challenges hindering PhD program reform? To engage these questions, we surveyed planning PhD students and program directors, gathered email input from planning prac

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Metzen, Eric. "Enzyme substrate recognition in oxygen sensing: how the HIF trap snaps." Biochemical Journal 408, no. 2 (2007): e5-e6. http://dx.doi.org/10.1042/bj20071306.

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The transcriptional activator HIF (hypoxia-inducible factor) is a focal point of biomedical research because many situations in physiology and in pathology coincide with hypoxia. The effects of HIF activation may be a facet of normal growth, as in embryonic development, they may counterbalance a disease, as seen in the stimulation of erythropoiesis in anaemia, and they may be part of the pathological processes, as exemplified by tumour angiogenesis. The oxygen-sensitive α-subunits of HIF are primarily regulated by the enzymatic hydroxylation that induces rapid proteasomal degradation. The HIFα

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May, Meiling, Stephen Desiderio, and John Thomas Bettridge. "An Allosteric Mechanism for Epigenetic Activation of the V(D)J Recombinase." Blood 132, Supplement 1 (2018): 512. http://dx.doi.org/10.1182/blood-2018-99-116675.

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Abstract V(D)J recombination, the process by which antigen receptor genes are assembled from discrete DNA segments during lymphoid development, is responsible for the generation of the primary immune repertoire. Errors in V(D)J recombination have been implicated in the pathogenesis of lymphoid malignancies, including follicular lymphoma, MALT lymphoma and mantle cell lymphoma. V(D)J recombination is initiated by a specialized transposase, RAG, consisting of RAG-1 and RAG-2 subunits. RAG mobilizes participating gene segments in a site-specific fashion by cleaving DNA at conserved recombination

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Эркинова, Маржона, Алишер Қаршиев та Дурдона Улугбековна Жанакова. "ЎРИКНИНГ РИВОЖЛАНИШИ ВА ҲОСИЛДОРЛИГИГА ТАШҚИ МУҲИТ ОМИЛЛАРИНИНГ ТАЪСИРИ". Role of agriculture and medicine in science va O'zbekiston Agrar fani xabarnomasi Maxsus son, № 1/1(19) 2025 (2025): 111–15. https://doi.org/10.5281/zenodo.14995944.

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<strong>634.21:71</strong> <strong>ЎРИКНИНГ РИВОЖЛАНИШИ ВА ҲОСИЛДОРЛИГИГА </strong><strong>ТАШҚИ МУҲИТ ОМИЛЛАРИНИНГ ТАЪСИРИ</strong> ТошДАУ, 2-босқич талабаси <strong>Эркинова Маржона</strong> erkinovam122@gmail.com ТошДАУ, “Мевачилик ва узумчилик” кафедраси (PhD), <strong>Қаршиев Алишер</strong> ТошДАУ, Мевачилик ва узумчилик кафедраси доценти (PhD), <strong>Жанакова Дурдона Улугбековна</strong> <strong> </strong> <strong>ВЛИЯНИЕ ВНЕШНИХ ФАКТОРОВ НА РАЗВИТИЕ И УРОЖАЙНОСТЬ АБРИКОСА</strong> ТашГАУ, студентка 2-го курса <strong>Эркинова Маржона</strong> ТашГАУ, кафедра «П

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Ulenikov, O. N., H. Bürger, W. Jerzembeck, G. A. Onopenko, E. S. Bekhtereva, and O. L. Petrunina. "The ground vibrational states of PH 2 D and PHD 2." Journal of Molecular Structure 599, no. 1-3 (2001): 225–37. http://dx.doi.org/10.1016/s0022-2860(01)00826-2.

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Schultz, Kelly, Vanishree Murthy, Jeffrey B. Tatro та Debbie Beasley. "Prolyl hydroxylase 2 deficiency limits proliferation of vascular smooth muscle cells by hypoxia-inducible factor-1α-dependent mechanisms". American Journal of Physiology-Lung Cellular and Molecular Physiology 296, № 6 (2009): L921—L927. http://dx.doi.org/10.1152/ajplung.90393.2008.

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Arterial O2 levels are thought to modulate vascular smooth muscle cell (VSMC) proliferation and vascular remodeling, but the mechanisms involved are poorly understood. Here, we tested the hypothesis that PHD2, a prolyl hydroxylase domain (PHD)-containing O2 sensor, modulates growth factor-induced proliferative responses of human pulmonary artery SMC (HPASMC). We found that both PHD1 and PHD2 were robustly expressed by HPASMC, and inhibiting prolyl hydroxylase activity pharmacologically by using the nonselective dioxygenase inhibitor dimethyloxalylglycine (DMOG) inhibited proliferation and cycl

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McCracken, Sharon A., Sean K. M. Seeho, Tamara Carrodus, et al. "Dysregulation of Oxygen Sensing/Response Pathways in Pregnancies Complicated by Idiopathic Intrauterine Growth Restriction and Early-Onset Preeclampsia." International Journal of Molecular Sciences 23, no. 5 (2022): 2772. http://dx.doi.org/10.3390/ijms23052772.

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Preeclampsia (PE) and intrauterine growth restriction (IUGR) are the leading causes of maternal and fetal morbidity/mortality. The central deficit in both conditions is impaired placentation due to poor trophoblast invasion, resulting in a hypoxic milieu in which oxidative stress contributes to the pathology. We examine the factors driving the hypoxic response in severely preterm PE (n = 19) and IUGR (n = 16) placentae compared to the spontaneous preterm (SPT) controls (n = 13) using immunoblotting, RT-PCR, immunohistochemistry, proximity ligation assays, and Co-IP. Both hypoxia-inducible fact

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Cagas, Steven, Stephen McCune, Pedro Rodriguez, et al. "416. Comparative Analytical Assessment of PCR Mastermixes for Detection of SARS-CoV-2 using the CDC Diagnostic Test and the LightMix Modular Test on the cobas® z 480 Analyzer." Open Forum Infectious Diseases 7, Supplement_1 (2020): S276. http://dx.doi.org/10.1093/ofid/ofaa439.610.

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Abstract Background The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a betacoronavirus responsible for the ongoing global pandemic and associated respiratory disease. Rapid development and implementation of molecular diagnostic testing solutions has been imperative to meet the enormous and urgent public health needs, and remains a key component of the US emergency response. Nucleic acid amplification tests (NAATs), with emergency use authorization (EUA) by the FDA, have been subject to significant supply chain shortages. This study aims to comparatively assess several

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van Tienoven, Theun Pieter, Anaïs Glorieux, Joeri Minnen, Petrus te Braak, and Bram Spruyt. "Graduate students locked down? PhD students’ satisfaction with supervision during the first and second COVID-19 lockdown in Belgium." PLOS ONE 17, no. 5 (2022): e0268923. http://dx.doi.org/10.1371/journal.pone.0268923.

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Background Supervisor support is crucial for the successful and timely completion of the PhD and the largest contributor to PhD students’ overall job satisfaction. The COVID-19 pandemic affected PhD students’ life substantially through delayed experiments, missed timelines, running out of funding, change to online team- and supervisor meetings, mandatory working from home, and social confinement. Aim This contribution considers PhD students’ satisfaction scores to reflect the extent to which PhD students felt supported by their supervisor during the COVID-19 pandemic so far and aims to investi

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Schultheis, Katherine, Charles C. Reed, Viviane M. Andrade, et al. "579. Design and Immunogenicity of a Pan-SARS-CoV-2 Synthetic DNA Vaccine." Open Forum Infectious Diseases 8, Supplement_1 (2021): S391—S392. http://dx.doi.org/10.1093/ofid/ofab466.777.

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Abstract Background First-generation COVID-19 vaccines are matched to spike protein of the Wuhan-H1 (WT) strain. Convalescent and vaccinee samples show reduced neutralization of SARS-CoV-2 variants of concern (VOC). Next generation DNA vaccines could be matched to single variants or synthetically designed for broader coverage of multiple VOCs. Methods The synthetic consensus (SynCon®) sequence for INO-4802 SARS-CoV-2 spike with focused RBD changes and dual proline mutations was codon-optimized (Figure 1). Sequences for wild-type (pWT) and B.1.351 (pB.1.351) were similarly optimized. Immunogeni

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Bøgelund, Pia, and Anette Kolmos. "Ph.d.-vejledning i et akademisk, markedsdrevet og samfundsforandrende perspektiv." Dansk Universitetspædagogisk Tidsskrift 8, no. 15 (2013): 99–111. http://dx.doi.org/10.7146/dut.v8i15.7145.

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Denne artikel identificerer og analyserer 3 idealtypiske ph.d.–vejledningsperspektiver, der korresponderer med forskellige forståelser af videnskabssyn og akademiske værdisæt. De 3 vejledningsperspektiver bygger på en interviewundersøgelse blandt 12 erfarne vejledere ved Det Teknisk-Naturvidenskabelige Fakultet på Aalborg Universitet. De identificeres på baggrund af vidensskabssyn og empirisk analyse, og udgør 1) et klassisk akademisk perspektiv; 2) et nyt management perspektiv, der i højere grad vægter projektledelse og produktivitet samt 3) et samfundsforandrende perspektiv baseret på

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Jia, Jing, and Nelson C. Y. Yeung. "“My Cross-Border PhD Journey”: A Qualitative Study on the Educational and Life Challenges of Mainland Chinese PhD Students in Hong Kong." International Journal of Environmental Research and Public Health 20, no. 12 (2023): 6078. http://dx.doi.org/10.3390/ijerph20126078.

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PhD students’ poor mental health has been increasingly concerning. However, challenges among PhD students studying aboard are understudied. The Educational and Life Transitions (ELT) model postulates that international PhD students are subject to both academic and acculturative stressors; however, relevant research is limited in the Chinese context. We examined mainland Chinese PhD students’ study and living experiences in Hong Kong using a qualitative approach. Through purposive sampling, 37 mainland Chinese PhD students in different disciplines from public-funded universities in Hong Kong we

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Choi, Bryan D., Michael R. DeLong, David M. DeLong, Allan H. Friedman, and John H. Sampson. "Impact of PhD training on scholarship in a neurosurgical career." Journal of Neurosurgery 120, no. 3 (2014): 730–35. http://dx.doi.org/10.3171/2013.11.jns122370.

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Object The purpose of this study was to report the prevalence of neurosurgeons with both medical degrees (MDs) and doctorates (PhDs) at top-ranked US academic institutions and to assess whether the additional doctorate education is associated with substantive career involvement in academia as well as greater success in procuring National Institutes of Health (NIH) research funding compared with an MD-only degree. Methods The authors reviewed the training of neurosurgeons across the top 10 neurosurgery departments chosen according to academic impact (h index) to examine whether MD-PhD training

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Wadams, Heather D., Nidhi Gupta, Paul Novotny, and Peter J. Tebben. "Onset of pituitary hormone deficiencies in optic nerve hypoplasia: a temporal trend analysis of 32 children at Mayo Clinic." Journal of Pediatric Endocrinology and Metabolism 33, no. 1 (2020): 139–45. http://dx.doi.org/10.1515/jpem-2019-0269.

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AbstractBackgroundThe objective of this study was to evaluate the age at onset and frequency of individual pituitary hormone deficiencies (PHDs) in optic nerve hypoplasia (ONH).MethodsWe performed a retrospective chart review of patients ≤21 years of age evaluated between 1996 and 2014. Patients were included if they had: (1) ONH diagnosed by an ophthalmologist and/or magnetic resonance imaging (MRI), (2) documentation of pituitary hormone function on at least two separate occasions and (3) at least one PHD documented or a midline abnormality of the brain on MRI.ResultsThirty-two patients (18

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Bettridge, John, Chan Hyun Na, Akhilesh Pandey, and Stephen Desiderio. "H3K4me3 induces allosteric conformational changes in the DNA-binding and catalytic regions of the V(D)J recombinase." Proceedings of the National Academy of Sciences 114, no. 8 (2017): 1904–9. http://dx.doi.org/10.1073/pnas.1615727114.

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V(D)J recombination is initiated by the recombination-activating gene (RAG) recombinase, consisting of RAG-1 and RAG-2 subunits. The susceptibility of gene segments to cleavage by RAG is associated with histone modifications characteristic of active chromatin, including trimethylation of histone H3 at lysine 4 (H3K4me3). Binding of H3K4me3 by a plant homeodomain (PHD) in RAG-2 stimulates substrate binding and catalysis, which are functions of RAG-1. This has suggested an allosteric mechanism in which information regarding occupancy of the RAG-2 PHD is transmitted to RAG-1. To determine whether

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Littzen, Chloé, Jennifer May, Jessica Rainbow, Helena Morrison, and Lois Loescher. "Pursuing Success in a Hybrid PhD Nursing Program." Journal of Nursing Education 63, no. 5 (2024): 328–31. http://dx.doi.org/10.3928/01484834-20240305-08.

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Background: Little is known about hybrid PhD nursing students' experiences. Method: The purpose of this study was to describe and analyze the experiences of PhD nursing students in a hybrid program using a convergent mixed methods design. Recent nursing PhD alumni ( n = 18), and current PhD students ( n = 4) were recruited at a research-intensive university in the southwestern United States. Results: Four metainferences were identified: (1) the facilitator of faculty as both advisors and mentors; (2) the facilitator of peers as support, motivation, and a source of advice that preceded advisors

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Grobler, Jay, Julie Strizki, Nicholas Murgolo, et al. "543. Molnupiravir Maintains Antiviral Activity Against SARS-CoV-2 Variants In Vitro and in Early Clinical Studies." Open Forum Infectious Diseases 8, Supplement_1 (2021): S373. http://dx.doi.org/10.1093/ofid/ofab466.742.

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Abstract Background Molnupiravir (MOV, MK-4482, EIDD-2801) is an orally administered prodrug of N-hydroxycytidine (NHC, EIDD-1931), a nucleoside with broad antiviral activity against a range of RNA viruses. MOV acts by driving viral error catastrophe following its incorporation by the viral RdRp into the viral genome. Given its mechanism of action, MOV activity should not be affected by substitutions in the spike protein present in SARS-CoV-2 variants of concern which impact efficacy of therapeutic neutralizing antibodies and vaccine induced immunity. We characterized MOV activity against vari

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Aparicio, Miriam. "Leadership as Social Competence in PhDs in Relation to Professional Achievement: Three Empirical Investigations." Athens Journal of Education 12, no. 2 (2025): 223–52. https://doi.org/10.30958/aje.12-2-3.

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Leadership assessment is analysed in 3 investigations: a) a quantitative study carried out with scientists (R&D), where a distinction between chief/leaders (units’ director or chief) and subordinate members in academic units of research was made; b) 2 qualitative studies also carried out at the third-level: the first one with PhDs from 4 National University of Cuyo Schools and the second one with PhDs/ PhD students from Argentina and other countries who participated in internationalization programmes in France. The latter is based on the hypothesis that the highest level of education achie

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Levin, Myron J., Andrew Ustianowski, Stéphane De Wit, et al. "LB5. PROVENT: Phase 3 Study of Efficacy and Safety of AZD7442 (Tixagevimab/Cilgavimab) for Pre-exposure Prophylaxis of COVID-19 in Adults." Open Forum Infectious Diseases 8, Supplement_1 (2021): S810. http://dx.doi.org/10.1093/ofid/ofab466.1646.

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Abstract Background Vaccines effectively prevent COVID-19, but some individuals have medical comorbidities or receive therapies that impair their immune response to vaccination, or are ineligible for vaccination. For such individuals who remain at risk of COVID-19, monoclonal antibodies may provide additional rapid protection. AZD7442 comprises 2 fully human extended half-life SARS-CoV-2–neutralizing antibodies that bind distinct epitopes of the viral spike protein receptor binding domain. AZD7442 is in development for the prevention and treatment of COVID-19. Here, we report primary Phase 3 s

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Lee, Kyungmee. "A Phenomenological Exploration of the Student Experience of Online PhD Studies." International Journal of Doctoral Studies 15 (2020): 575–93. http://dx.doi.org/10.28945/4645.

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Aim/Purpose: This article investigates thirteen students’ lived experiences on an online PhD programme, aiming to develop a better understanding of the nature of doing a PhD online. Background: A large number of adult students with full-time professional roles and other social responsibilities have returned to universities to pursue their doctoral degree in order to advance their personal and professional lives. Online PhD programmes are now one of the viable choices for those who wish to combine their PhD study with other professional and personal roles. However, little has been known about s

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Strizki, Julie, Jay Grobler, Ying Zhang, et al. "511. Treatment with Molnupiravir in the MOVe-In and MOVe-Out Clinical Trials Results in an Increase in Transition Mutations Across the SARS-CoV-2 Genome." Open Forum Infectious Diseases 8, Supplement_1 (2021): S357—S358. http://dx.doi.org/10.1093/ofid/ofab466.710.

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Abstract Background Molnupiravir (MOV), (MK-4482, EIDD-2801) is being clinically developed for the treatment of COVID-19 disease caused by SARS-CoV-2. MOV is the orally administered 5′-isobutyrate prodrug of the active, antiviral ribonucleoside analogue, N-hydroxycytidine (NHC, EIDD-1931) which inhibits viral replication by induction of mutations in the viral genome, leading to viral error catastrophe. In 2 clinical studies, hospitalized (MOVe-In) and non-hospitalized (MOVe-Out) participants were treated for 5 days with MOV and followed up to Day 29. Viral RNA isolated from nasal swab samples

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Vares, Yan, Olexandr Tymofieiev, Serhii Maksymcha, et al. "Academic Degrees of Candidate of Sciences and Doctor of Philosophy Obtained by Oral and Maxillofacial Surgeons in Ukraine: Comparison of Print Diplomas and Their Digital Analogs in Diia (Action) Application: A Narrative Review." Journal of Diagnostics and Treatment of Oral and Maxillofacial Pathology 9, no. 2 (2025): 1–22. https://doi.org/10.23999/j.dtomp.2025.2.100302.

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The purpose of this narrative review is to analyze the transition of the Candidate of Sciences (CSc) to the Doctor of Philosophy (PhD) academic degree among doctors who defended their theses in modern Ukraine and who specialize in Surgical Dentistry (i.e., Oral Surgery) and Maxillofacial Surgery. The following were highlighted: (1) regulatory documents regarding obtaining a CSc/PhD degree, (2) institutions that issued and issue diplomas and diploma supplements of CSc/PhD, (3) eight CSc and PhD diplomas awarded to citizens of Ukraine and foreigners since 2002, as well as supplements to diplomas

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Grabber, John H., Damon L. Smith, William R. Osterholz, and Mark J. Renz. "Establishment and First Year Yield of Interseeded Alfalfa as Influenced by Corn Plant Density and Treatment with Prohexadione, Fungicide and Insecticide." Agronomy 11, no. 11 (2021): 2343. http://dx.doi.org/10.3390/agronomy11112343.

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Interseeding alfalfa (Medicago sativa L.) into a silage corn (Zea mays L.) companion crop can increase the yield and profitability of forage production and reduce the risk of nutrient and soil loss from cropland, but unreliable establishment of alfalfa hampers the adoption of this practice on dairy farms. This study evaluated plant survival, foliar health, and dry matter yields of two alfalfa varieties when established in corn sown at populations ranging from about 47,500 to 100,000 plants per ha−1 and when treated with prohexadione (PHD), PHD followed by fungicide and insecticide (PHD-FI), or

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Atanassova, Penka, Maria Tokmakova, Albena Djurkova, Vulcho Naydenov, Nedka Chalakova, and Borislav Dimitrov. "Abnormal ECG patterns during the acute phase of subarachnoid hemorrhage in patients without previous heart disease." Open Medicine 1, no. 2 (2006): 148–57. http://dx.doi.org/10.2478/s11536-006-0018-7.

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AbstractSubarachnoid hemorrhage (SAH) occurs primarily during early to mid-adulthood; approximately 30% of individuals with SAH die within 2 weeks, and mortality is 30% to 45%. SAH happens suddenly, without patients being aware of previous heart abnormalities. Here, we performed a pilot single cohort (historical) study to examine the hypothesis that early abnormal electrocardiographic (ECG) changes may reveal unknown but “silent” heart pathologies in SAH patients without previous heart disease (PHD). Data were collected retrospectively on 56 consecutive patients during the acute phase of SAH (

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