Relevant bibliographies by topics / PhD domain

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'PhD domain'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "PhD domain"

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Takeda, Kotaro, Hector L. Aguila, Nehal S. Parikh, et al. "Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins." Blood 111, no. 6 (2008): 3229–35. http://dx.doi.org/10.1182/blood-2007-09-114561.

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Abstract Polycythemia is often associated with erythropoietin (EPO) overexpression and defective oxygen sensing. In normal cells, intracellular oxygen concentrations are directly sensed by prolyl hydroxylase domain (PHD)–containing proteins, which tag hypoxia-inducible factor (HIF) α subunits for polyubiquitination and proteasomal degradation by oxygen-dependent prolyl hydroxylation. Here we show that different PHD isoforms differentially regulate HIF-α stability in the adult liver and kidney and suppress Epo expression and erythropoiesis through distinct mechanisms. Although Phd1−/− or Phd3−/− mice had no apparent defects, double knockout of Phd1 and Phd3 led to moderate erythrocytosis. HIF-2α, which is known to activate Epo expression, accumulated in the liver. In adult mice deficient for PHD2, the prototypic Epo transcriptional activator HIF-1α accumulated in both the kidney and liver. Elevated HIF-1α levels were associated with dramatically increased concentrations of both Epo mRNA in the kidney and Epo protein in the serum, which led to severe erythrocytosis. In contrast, heterozygous mutation of Phd2 had no detectable effects on blood homeostasis. These findings suggest that PHD1/3 double deficiency leads to erythrocytosis partly by activating the hepatic HIF-2α/Epo pathway, whereas PHD2 deficiency leads to erythrocytosis by activating the renal Epo pathway.
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Takeda, Kotaro, Vivienne C. Ho, Hiromi Takeda, Li-Juan Duan, Andras Nagy та Guo-Hua Fong. "Placental but Not Heart Defects Are Associated with Elevated Hypoxia-Inducible Factor α Levels in Mice Lacking Prolyl Hydroxylase Domain Protein 2". Molecular and Cellular Biology 26, № 22 (2006): 8336–46. http://dx.doi.org/10.1128/mcb.00425-06.

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ABSTRACT PHD1, PHD2, and PHD3 are prolyl hydroxylase domain proteins that regulate the stability of hypoxia-inducible factor α subunits (HIF-α). To determine the roles of individual PHDs during mouse development, we disrupted all three Phd genes and found that Phd2 − / − embryos died between embryonic days 12.5 and 14.5 whereas Phd1 −/− or Phd3 −/− mice were apparently normal. In Phd2 − / − mice, severe placental and heart defects preceded embryonic death. Placental defects included significantly reduced labyrinthine branching morphogenesis, widespread penetration of the labyrinth by spongiotrophoblasts, and abnormal distribution of trophoblast giant cells. The expression of several trophoblast markers was also altered, including an increase in the spongiotrophoblast marker Mash2 and decreases in the labyrinthine markers Tfeb and Gcm1. In the heart, trabeculae were poorly developed, the myocardium was remarkably thinner, and interventricular septum was incompletely formed. Surprisingly, while there were significant global increases in HIF-α protein levels in the placenta and the embryo proper, there was no specific HIF-α increase in the heart. Taken together, these data indicate that among all three PHD proteins, PHD2 is uniquely essential during mouse embryogenesis.
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Pappalardi, Melissa B., Dean E. McNulty, John D. Martin, et al. "Biochemical characterization of human HIF hydroxylases using HIF protein substrates that contain all three hydroxylation sites." Biochemical Journal 436, no. 2 (2011): 363–69. http://dx.doi.org/10.1042/bj20101201.

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The HIF (hypoxia-inducible factor) plays a central regulatory role in oxygen homoeostasis. HIF proteins are regulated by three Fe(II)- and α-KG (α-ketoglutarate)-dependent prolyl hydroxylase enzymes [PHD (prolyl hydroxylase domain) isoenzymes 1–3 or PHD1, PHD2 and PHD3] and one asparaginyl hydroxylase [FIH (factor inhibiting HIF)]. The prolyl hydroxylases control the abundance of HIF through oxygen-dependent hydroxylation of specific proline residues in HIF proteins, triggering subsequent ubiquitination and proteasomal degradation. FIH inhibits the HIF transcription activation through asparagine hydroxylation. Understanding the precise roles and regulation of these four Fe(II)- and α-KG-dependent hydroxylases is of great importance. In the present paper, we report the biochemical characterization of the first HIF protein substrates that contain the CODDD (C-terminal oxygen-dependent degradation domain), the NODDD (N-terminal oxygen-dependent degradation domain) and the CAD (C-terminal transactivation domain). Using LC-MS/MS (liquid chromatography–tandem MS) detection, we show that all three PHD isoenzymes have a strong preference for hydroxylation of the CODDD proline residue over the NODDD proline residue and the preference is observed for both HIF1α and HIF2α protein substrates. In addition, steady-state kinetic analyses show differential substrate selectivity for HIF and α-KG in reference to the three PHD isoforms and FIH.
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Barth, Sandra, Jutta Nesper, Philippe A. Hasgall, et al. "The Peptidyl Prolyl cis/trans Isomerase FKBP38 Determines Hypoxia-Inducible Transcription Factor Prolyl-4-Hydroxylase PHD2 Protein Stability." Molecular and Cellular Biology 27, no. 10 (2007): 3758–68. http://dx.doi.org/10.1128/mcb.01324-06.

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ABSTRACT The heterodimeric hypoxia-inducible transcription factors (HIFs) are central regulators of the response to low oxygenation. HIF-α subunits are constitutively expressed but rapidly degraded under normoxic conditions. Oxygen-dependent hydroxylation of two conserved prolyl residues by prolyl-4-hydroxylase domain-containing enzymes (PHDs) targets HIF-α for proteasomal destruction. We identified the peptidyl prolyl cis/trans isomerase FK506-binding protein 38 (FKBP38) as a novel interactor of PHD2. Yeast two-hybrid, glutathione S-transferase pull-down, coimmunoprecipitation, colocalization, and mammalian two-hybrid studies confirmed specific FKBP38 interaction with PHD2, but not with PHD1 or PHD3. PHD2 and FKBP38 associated with their N-terminal regions, which contain no known interaction motifs. Neither FKBP38 mRNA nor protein levels were regulated under hypoxic conditions or after PHD inhibition, suggesting that FKBP38 is not a HIF/PHD target. Stable RNA interference-mediated depletion of FKBP38 resulted in increased PHD hydroxylation activity and decreased HIF protein levels and transcriptional activity. Reconstitution of FKBP38 expression abolished these effects, which were independent of the peptidyl prolyl cis/trans isomerase activity. Downregulation of FKBP38 did not affect PHD2 mRNA levels but prolonged PHD2 protein stability, suggesting that FKBP38 is involved in PHD2 protein regulation.
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Wu, Qi, and Chuan Tang Wang. "Genome Wide Analysis of PHD Finger Family in Soybean (Glycine max)." Advanced Materials Research 864-867 (December 2013): 2503–8. http://dx.doi.org/10.4028/www.scientific.net/amr.864-867.2503.

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The PHD finger is a highly conserved structural domain in roles with regulating transcription and modification of chromatin structure. Forty-five PHD finger genes encoding PHD finger protein were identified from soybean (Glycine max) database. And sixty - four unique typical PHD finger domains were retrieved. NJ phylogenetic tree of all 64 PHD finger domains consisted of ten main clades (A-J). Subcellular localization analysis shows that Glyma06g33590.1, Glyma10g05080.1 and Glyma11g11720.1 may localize in Golgi body, chloroplast thylakoid membrane and mitochondrial inner membrane, respectively. The function of domain is loyal to the cause of protein situated in particular site of cell. Eight unique domains have been found concomitant with PHD domain in a certain protein. The cooperative relationship between diverse domains may important for particular biological event.
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Kampantais, Spyridon, Ilias Kounatidis, Vasiliki Kotoula, Ioannis Vakalopoulos, Konstantinos Gkagkalidis, and Georgios Dimitriadis. "Decreased prolyl hydroxylase 3 mRNA expression in oncocytomas compared with clear cell renal cell carcinoma." International Journal of Biological Markers 35, no. 4 (2020): 80–86. http://dx.doi.org/10.1177/1724600820960478.

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Introduction: Hypoxia inducible factors (HIF) and prolyl hydroxylase domain (PHD) enzymes play a central role in tumor progression in clear cell renal cell carcinoma (ccRCC). However, there are currently no data regarding the behavior of this pathway (HIF/PHD) in a large number of benign renal tumors, the oncocytomas. The aim of the present study was to compare the expression levels of these factors between ccRCC and oncocytoma tumors. Material and methods: A total of 56 fresh frozen specimens from patients with ccRCC and 14 oncocytoma specimens were analyzed via reverse transcription-quantitative polymerase chain reaction in order to assess the expression levels of HIF-1α, HIF-2α, PHD1, PHD2, and PHD3. The analysis involved both fresh frozen tumor samples as well as adjacent normal kidney tissues. Results: In ccRCC, HIF-1α and HIF-2α levels were upregulated in 65.5% and 71.4% of cases, respectively. PHD3 was downregulated only in 15.4% of the ccRCC cases, in contrast with oncocytoma cases, which exhibited low expression levels in the majority. The upregulation of PHD3 messenger RNA (mRNA) levels in ccRCC when compared with oncocytoma was statistically significant ( P<0.001). No other comparisons (HIF-1α, HIF-2α, PHD1, and PHD2) were significantly different. HIF-2α and PHD3 mRNA expression levels were negatively correlated with Fuhrman Grade ( P=0.029 and P=0.026, respectively) in ccRCC. Conclusion: To the best of our knowledge, this is the first time that the HIF/PHD pathway was compared between ccRCC and a common benign tumor, identifying the upregulation of PHD3 as the possible underlying factor guiding the difference in the behavior of ccRCC.
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Köditz, Jens, Jutta Nesper, Marieke Wottawa, et al. "Oxygen-dependent ATF-4 stability is mediated by the PHD3 oxygen sensor." Blood 110, no. 10 (2007): 3610–17. http://dx.doi.org/10.1182/blood-2007-06-094441.

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Abstract The activating transcription factor-4 (ATF-4) is translationally induced under anoxic conditions, mediates part of the unfolded protein response following endoplasmic reticulum (ER) stress, and is a critical regulator of cell fate. Here, we identified the zipper II domain of ATF-4 to interact with the oxygen sensor prolyl-4-hydroxylase domain 3 (PHD3). The PHD inhibitors dimethyloxalylglycine (DMOG) and hypoxia, or proteasomal inhibition, all induced ATF-4 protein levels. Hypoxic induction of ATF-4 was due to increased protein stability, but was independent of the ubiquitin ligase von Hippel–Lindau protein (pVHL). A novel oxygen-dependent degradation (ODD) domain was identified adjacent to the zipper II domain. Mutations of 5 prolyl residues within this ODD domain or siRNA-mediated down-regulation of PHD3, but not of PHD2, was sufficient to stabilize ATF-4 under normoxic conditions. These data demonstrate that PHD-dependent oxygen-sensing recruits both the hypoxia-inducible factor (HIF) and ATF-4 systems, and hence not only confers adaptive responses but also cell fate decisions.
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Machado, Luciana E. F., Yulia Pustovalova, Andrew C. Kile, et al. "PHD domain from human SHPRH." Journal of Biomolecular NMR 56, no. 4 (2013): 393–99. http://dx.doi.org/10.1007/s10858-013-9758-2.

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Zheng, Shuangping, Yucong Bi, Haining Chen, Bo Gong, Shunji Jia, and Haitao Li. "Molecular basis for bipartite recognition of histone H3 by the PZP domain of PHF14." Nucleic Acids Research 49, no. 15 (2021): 8961–73. http://dx.doi.org/10.1093/nar/gkab670.

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Abstract Histone recognition constitutes a key epigenetic mechanism in gene regulation and cell fate decision. PHF14 is a conserved multi-PHD finger protein that has been implicated in organ development, tissue homeostasis, and tumorigenesis. Here we show that PHF14 reads unmodified histone H3(1–34) through an integrated PHD1-ZnK-PHD2 cassette (PHF14PZP). Our binding, structural and HDX-MS analyses revealed a feature of bipartite recognition, in which PHF14PZP utilizes two distinct surfaces for concurrent yet separable engagement of segments H3-Nter (e.g. 1–15) and H3-middle (e.g. 14–34) of H3(1–34). Structural studies revealed a novel histone H3 binding mode by PHD1 of PHF14PZP, in which a PHF14-unique insertion loop but not the core β-strands of a PHD finger dominates H3K4 readout. Binding studies showed that H3-PHF14PZP engagement is sensitive to modifications occurring to H3 R2, T3, K4, R8 and K23 but not K9 and K27, suggesting multiple layers of modification switch. Collectively, our work calls attention to PHF14 as a ‘ground’ state (unmodified) H3(1–34) reader that can be negatively regulated by active marks, thus providing molecular insights into a repressive function of PHF14 and its derepression.
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Li, Ningjun, Fan Yi, Christina M. Sundy, et al. "Expression and actions of HIF prolyl-4-hydroxylase in the rat kidneys." American Journal of Physiology-Renal Physiology 292, no. 1 (2007): F207—F216. http://dx.doi.org/10.1152/ajprenal.00457.2005.

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Hypoxia inducible factor (HIF) prolyl-4-hydroxylase domain-containing proteins (PHDs) promote the degradation of HIF-1α. Because HIF-1α is highly expressed in the renal medulla and HIF-1α-targeted genes such as nitric oxide synthase, cyclooxygenase, and heme oxygenase are important in the regulation of renal medullary function, we hypothesized that PHD regulates HIF-1α levels in the renal medulla and, thereby, participates in the control of renal Na+ excretion. Using real-time RT-PCR, Western blot, and immunohistochemical analyses, we have demonstrated that all three isoforms of PHD, PHD1, PHD2, and PHD3, are expressed in the kidneys and that PHD2 is the most abundant isoform. Regionally, all PHDs exhibited much higher levels in renal medulla than cortex. A furosemide-induced increase in renal medullary tissue Po2 significantly decreased PHD levels in renal medulla, whereas hypoxia significantly increased mRNA levels of PHDs in cultured renal medullary interstitial cells, indicating that O2 regulates PHDs. Functionally, the PHD inhibitor l-mimosine (l-Mim, 50 mg·kg−1·day−1 ip for 2 wk) substantially upregulated HIF-1α expression in the kidneys, especially in the renal medulla, and remarkably enhanced (by >80%) the natriuretic response to renal perfusion pressure in Sprague-Dawley rats. Inhibition of HIF transcriptional activity by renal medullary transfection of HIF-1α decoy oligodeoxynucleotides attenuated l-Mim-induced enhancement of pressure natriuresis, which confirmed that HIF-1α mediated the effect of l-Mim. These results indicate that highly expressed PHDs in the renal medulla make an important contribution to the control of renal Na+ excretion through regulation of HIF-1α and its targeted genes.
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Dissertations / Theses on the topic "PhD domain"

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Deeves, Sian Elizabeth. "Novel functions of the MOZ double PHD finger domain." Thesis, University of Nottingham, 2012. http://eprints.nottingham.ac.uk/12503/.

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Monocytic leukaemia zinc-finger protein (MOZ) is a histone acetyltransferase (HAT) implicated in haematopoiesis and acute myeloid leukaemia, as well as embryonic and postnatal development. MOZ contains multiple domains, including a MYST HAT domain and a double PHD finger domain (DPF) suggesting it interacts with histones. This work has established for the first time that the MOZ DPF exhibits dual functionality in establishing and sensing post-translational modifications (PTMs) of histones. Firstly, our data detected the direct interaction of MOZ with the N-terminal tails of histones H3 and H4 and shows that the MOZ DPF domain mediates such binding. Both PHD fingers are required and functionally cooperate to establish the DPF histone binding preference in terms of PTMs. We demonstrate that H3K4me3 prevents MOZ DPF association with H3, although H3K4me2 is tolerated. Similarly, H4Kac acts as a dominant exit signal that excludes MOZ from chromatin. This ability to sense H3K4 PTM status was confirmed in a collaborative effort establishing the crystal structure of MOZ DPF in complex with an unmodified H3 peptide. The H3 peptide adopted an α-helical conformation in the complex, which has not previously been observed. Secondly, we present novel data showing that the MOZ DPF domain exhibits a mild histone H3-specific acetyltransferase activity. This provides the first report of a possible enzymatic role in chromatin modification attributed to a PHD finger. Furthermore, the combined DPF and MYST domains were found to influence the reaction rate and substrate specificity of MOZ-induced histone acetylation. Our studies revealed that the MOZ DPF could associate with heterochromatic PTMs, namely H3K9me3. We report here that both the H3K9-specific methyltransferase SUV39H1 and heterochromatin protein 1 (HP1) form interactions with MOZ, implicating its function in both corepressor and coactivator complexes. Thus, our data suggest that like several other chromatin-associated proteins, MOZ is a multi-functional regulator of chromatin modification and gene expression.
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Delvecchio, Manuela. "Mécanisme de régulation de l'acétyltransférase p300/CBP." Phd thesis, Université de Grenoble, 2011. http://tel.archives-ouvertes.fr/tel-00631344.

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Le p300/CBP acétyltransférase est un co-activateur transcriptionnel très important qui est impliqué dans la régulation d'un grand nombre de processus biologiques, comme la transcription d'ADN, le développement et l'immunité innée. Jusqu'à présent, le rôle de p300/CBP dans la régulation de l'expression des gènes a été largement étudiée, mais les mécanismes qui régulent son activité enzymatique sont encore peu connus. Des études ont montré que le dysfonctionnement de p300/CBP est associé à plusieurs formes de cancer et de maladies neurodégénératives. Dés lors, chaque progrès concernant les mécanismes de régulation de p300/CBP est devenu primordial pour le développement de nouvelles thérapies. Le 'noyau' de p300/CBP contient deux domaines pour la reconnaissance des modifications post-traductionnelles (MPTs), un bromodomaine et un PHD finger (le module BP), adjacent à un domaine HAT (ou domaine histone acétyltransférase). Plusieurs enzymes, modifiant la chromatine, contiennent des domaines de reconnaissance des MPTs. Fréquemment des groupements particuliers de ces domaines sont très conservés et liés, au sein de la même protéine ou du même complexe protéique, suggérant qu'ils réalisent des fonctions coordonnées. Ces domaines adjacents peuvent agir en concertation dans la reconnaissance simultanée de différents MPTs ou peuvent exercer des fonctions différentes de celles qui sont effectuées par ces deux domaines particuliers, tels que les fonctions de régulation enzymatique. Plusieurs études suggèrent que les cycles acétylation/désacétylation dans la boucle d'auto-inhibition, à l'intérieur du domaine HAT, jouent un rôle important dans la régulation de l'activité enzymatique de p300/CBP. La proximité du module BP et du domaine HAT suggère que la spécificité de liaison, appartenant au module BP, peut être intrinsèquement liée à la régulation de l'activité du domaine HAT. L'objectif de ma thèse est de déterminer le rôle du module BP dans la régulation de l'activité du domaine HAT. Je propose que le module BP soit impliqué dans la régulation de p300/CBP de deux façons. La première consiste à établir un lien avec le domaine HAT qui stabilise la conformation auto-inhibée de l'enzyme. La deuxième exige que le module BP joue un rôle dans le choix des substrats de p300/CBP. J'ai été en mesure de montrer que BP peut se lier au domaine HAT et à la chromatine modifiée et qu'il peut reconnaître les modifications effectuées par p300/CBP lui-même. Les données obtenues indiquent que le module BP peut être impliqué dans la régulation de l'activité de p300/CBP et dans son ciblage à la chromatine.
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Wijeyekoon, Jananath Bhathiya. "Tissue expression and functional insights into HIF prolyl hydroxylase domain enzymes." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:6330e4d5-0802-427b-a7b3-8895d94e02f2.

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This research programme investigated the expression of prolyl hydroxylase (PHD) proteins in rodent tissues. The importance of PHD enzymes lies in their ability to render oxygen sensitivity to Hypoxia inducible factor (HIF), the principal mediator of intracellular oxygen homeostasis. The first part of this study focused on developing and validating anti-sera capable of detecting PHD proteins in rodent tissues. With these reagents, it was possible to assess the relative expression of each PHD protein in a number of different rat tissues. PHD2 was the most abundant isoform in all tissues studied. In contrast, an abundance of PHD1 was observed only in testis and skeletal muscle. A number of different tissue species of PHD3 were identified and their abundance was found to vary between different tissues. These observations provide further evidence of the principal role of PHD2 in regulating HIF in vivo, but also point towards additional roles for PHD1 and PHD3 in selected tissues. They highlight the potential for there being a complex interplay between different PHD enzymes which could, in the future, prove potential targets for therapeutic manipulation. This study also provides additional insights into the mechanisms underlying the phenotypes observed in PHD deletional mouse models which appear, in many cases, to be directly related to the abundance of a given PHD isoform. The emerging role of PHD3 as a promoter of sympathetic lineage apoptosis prompted further study of PHD3 expression in rat neuronal tissues. An abundance of PHD3 was demonstrated throughout the rat sympathetic nervous system, a finding which appeared at odds with its known role as a promoter of neuronal apoptosis and resulted in a series of collaborative studies which demonstrated a sympatho-adrenal phenotype in wild type compared to PHD3-/- mice. Further collaborative studies utilising wild type mice and those deleted of specific PHD isoforms, were carried out to assess the significance of the abundance of PHD3 and PHD1 noted here in rat hippocampus and testis respectively. While neither study demonstrated statistically significant phenotypes, these observations remain of interest and areas for future research.
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Jiang, Yugang. "Large scale semantic concept detection, fusion, and selection for domain adaptive video search /." access full-text access abstract and table of contents, 2009. http://libweb.cityu.edu.hk/cgi-bin/ezdb/thesis.pl?phd-cs-b23749957f.pdf.

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Thesis (Ph.D.)--City University of Hong Kong, 2009.<br>"Submitted to Department of Computer Science in partial fulfillment of the requirements for the degree of Doctor of Philosophy." Includes bibliographical references (leaves 145-161)
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Mitra, Sayantan. "Arabidopsis Cohesin proteins: WAPL, CTF7 and PHD finger proteins: MMDL1, MMDL2 are essential for proper meiosis, gamete development and plant growth." Miami University / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=miami1517605898967702.

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Dhamodharan, Neelamegan. "Characterisation of PhdB, a pleckstrin homology domain containing protein in Dictyostelium discoideum." [S.l. : s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=972300252.

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Wang, Suqin. "Magnetization dynamics of single domain nanomagnets /." Diss., Digital Dissertations Database. Restricted to UC campuses, 2007. http://uclibs.org/PID/11984.

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Hansen, Marc D. "An analysis of the diagrammatic visual data querying domain /." Diss., Digital Dissertations Database. Restricted to UC campuses, 2005. http://uclibs.org/PID/11984.

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Holt-Martyn, James. "Novel and selective small molecule inhibitors and activators for the prolyl hydroxylase domain enzyme." Thesis, University of Oxford, 2018. http://ora.ox.ac.uk/objects/uuid:4b3613c5-5ff3-43b0-a07e-cf3116a37c1b.

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Hypoxia Inducible Factors (HIF) functions are master regulators of oxygen homeostasis and have a key role in the physiological responses to hypoxia including angiogenesis and erythropoiesis. Under hypoxia, levels of HIF-α subunits increase, they hetereodimerise with HIF-1β sub unit and promote the initiation of transcription of target genes. Under normoxia, oxygen dependent HIF-α degradation is promoted by hydroxylation of either of two proline residues (Pro402 and Pro564). The interaction of prolylhydroxylated HIF-α with the Von Hippel-Lindau protein (pVHL) promotes hydrolytic degradation of HIFα through an E3 ubiquitin ligase proteasomal pathway. HIF prolyl hydroxylation is catalysed by three 2-oxoglutarate (2OG)-dependent oxygenases known as prolyl hydroxylase domain (PHD 1-3) proteins, through an Fe(II) mediated catalytic process using 2OG, and oxygen. The PHDs are part of the family of Fe(II) bound 2OG dependent oxygenases. There are approximately 70 human 2OG oxygenases many of which have biologically important roles. Small-molecule inhibitors have reached advanced clinical trials; however, many clinical candidates inhibit other structurally similar 2OG oxygenases (OGFOD1 and vCPH) potentially altering the therapeutic effect. This thesis describes the design and synthesis of potent and 2OG oxygenase selective inhibitors for the PHDs. The 1,3,8-triazaspiro[4.5]decane-2,4-dione and 4-hydroxy-2-(pyrazole)pyrimidine-5-amide series were chosen as initial 'hits' (reported in the patent literature). The main analogues of the series were characterised in vitro and in cells as potent and selective PHD inhibitors over structurally similar 2OG oxygenases (Chapter 2). Broad structure activity relationship (SAR) of both initial series demonstrated the sensitivity for PHD2 inhibition (Chapter 3). Combination of SAR work described in Chapters 2 and 3 lead to the development of the novel 4-hydroxy pyridine series. In-depth SAR resulted in optimised analogues including 1 (IC50 69 nM) and highly selective over structurally similar 2OG oxygenases including OGFOD1. The completed SAR work led to the development of two novel pharmacophores 2 and 3. Both pharmacophores displayed potent PHD inhibition and selectivity over OGFOD1. Analogues including 1 and 3 displayed on target cellular activity stabilising HIF-1α at 20 μM (Chapter 4). The 4-dimethylamine pyridine analogue displayed an increase in substrate hydroxylation on PHD2 in contrast to the DMSO control (Chapter 3). SAR and cellular characterisation indicated that the effect observed was not an assay artifact (Chapter 5). Fenofibrate was used as a starting point for the development of novel inhibitors of the oxygen consumption rate (OCR) via mitochondrial inhibition (Chapter 6). Analogues were synthesised in order to conduct broad SAR and on-target cellular activity was observed in a Seahorse XF assay (50% reduction in the OCR at 1 μM). A selection of amino and amide analogues warrant further investigation.
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Słowiński, Witold. "Autonomous learning of domain models from probability distribution clusters." Thesis, University of Aberdeen, 2014. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=211059.

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Nontrivial domains can be difficult to understand and the task of encoding a model of such a domain can be difficult for a human expert, which is one of the fundamental problems of knowledge acquisition. Model learning provides a way to address this problem by allowing a predictive model of the domain's dynamics to be learnt algorithmically, without human supervision. Such models can provide insight about the domain to a human or aid in automated planning or reinforcement learning. This dissertation addresses the problem of how to learn a model of a continuous, dynamic domain, from sensory observations, through the discretisation of its continuous state space. The learning process is unsupervised in that there are no predefined goals, and it assumes no prior knowledge of the environment. Its outcome is a model consisting of a set of predictive cause-and-effect rules which describe changes in related variables over brief periods of time. We present a novel method for learning such a model, which is centred around the idea of discretising the state space by identifying clusters of uniform density in the probability density function of variables, which correspond to meaningful features of the state space. We show that using this method it is possible to learn models exhibiting predictive power. Secondly, we show that applying this discretisation process to two-dimensional vector variables in addition to scalar variables yields a better model than only applying it to scalar variables and we describe novel algorithms and data structures for discretising one- and two-dimensional spaces from observations. Finally, we demonstrate that this method can be useful for planning or decision making in some domains where the state space exhibits stable regions of high probability and transitional regions of lesser probability. We provide evidence for these claims by evaluating the model learning algorithm in two dynamic, continuous domains involving simulated physics: the OpenArena computer game and a two-dimensional simulation of a bouncing ball falling onto uneven terrain.
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Books on the topic "PhD domain"

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1968-, Arvesú Jorge, and Lopez Lagomasino Guillermo 1948-, eds. Recent advances in orthogonal polynomials, special functions, and their applications: 11th International Symposium on Orthogonal Polynomials, Special Functions, and Their Applications, August 29-September 2, 2011, Universidad Carlos III de Madrid, Leganes, Spain. American Mathematical Society, 2012.

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Sahay, Sundeep, T. Sundararaman, and Jørn Braa. Public Health Informatics. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198758778.003.0001.

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This chapter situates public health informatics (PHI) within an informatics perspective and the two broad trends relevant to its understanding; the first concerns medical and health informatics, which focuses on the application of information and communications technologies for the better understanding of the human body. This includes clinical, nursing, radiology, drug-related informatics, among others. This domain has been driven largely by clinicians, and informed by the disciplines of medicine, informatics, and cognitive and behavioural psychology. This field of study and practice has largely been focused on in North America and Europe, while low and middle-income countries (LMICs) have broadly been excluded. The second trend is of PHI systems, which have focused on the population, and practised the collection and use of aggregate statistics. This focus has largely been promoted by statisticians and demographers, and practised primarily in LMICs. These two trends have remained isolated from each other, yet evolved simultaneously.
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Klein, Daniel N., Sara J. Bufferd, Eunyoe Ro, and Lee Anna Clark. Depression and Comorbidity. Edited by C. Steven Richards and Michael W. O'Hara. Oxford University Press, 2014. http://dx.doi.org/10.1093/oxfordhb/9780199797004.013.025.

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This chapter examines the relation between personality disorder (PD) and depression, disorders that are commonly comorbid in clinical and community populations. This comorbidity presents both clinical and conceptual challenges. In anticipation of the upcoming introduction of theDiagnostic and Statistical Manual of Mental Disorders(fifth edition;DSM-5), we review research on the associations of depression with both PD and traits in order to help bridge the current and future literatures. Issues distinguishing PD and depression are reviewed, including conceptual concerns, the nature of the associations between depression and PD and traits, and current evidence on associations between depression and PD and chief personality trait dimensions. Data are presented from an ongoing study examining associations between depressive symptoms, maladaptive-range personality, and psychosocial functioning using proposedDSM-5criteria for depression and PD trait domains and facets. Depressive disorders exhibit large associations with negative affect and more moderate links with positive affect and conscientiousness/disinhibition, though there appear to be even more differentiated patterns of associations at the facet level. However, our understanding of the processes responsible for the associations of PD and depression is still limited. Despite this lack of clarity, the links between depression and PD and traits have important clinical implications for assessment and treatment of both disorders. Assessment approaches and challenges are discussed, as well as the implications of co-occurring PD and traits for the treatment of depressive disorders. Finally, future research directions are summarized.
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Popescu, Bogdan A., Shantanu P. Sengupta, Niloufar Samiei, and Anca D. Mateescu. Heart valve disease (mitral valve disease): mitral stenosis. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198726012.003.0035.

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The most common cause of mitral stenosis (MS) is rheumatic fever followed by degenerative MS. Echocardiography is the key method to diagnose and evaluate MS. Echocardiographic findings are closely related to aetiology. In rheumatic disease echocardiography shows thickening of leaflet tips with restricted opening caused by commissural fusion resulting in ‘doming’ of the mitral valve in diastole. Quantitation of MS severity includes measuring mitral valve area (MVA) by planimetry (anatomical area, by two-/three-dimensional echo), or by the pressure half-time (PHT) method (functional area, by Doppler), and the mean pressure gradient. Planimetry is considered the reference method to determine MVA as it is relatively load independent. The PHT method is widely used due to its simplicity, but different factors influence the relationship between PHT and MVA. Other indices of MS severity are rarely used in clinical practice. Echocardiography also helps in the assessment of consequences of MS, and of associated valvular lesions. Exercise Doppler is recommended when there is discrepancy between the resting echocardiography findings and the clinical picture. Echocardiography is crucial in determining the timing and type of intervention in patients with MS. When considering percutaneous mitral commissurotomy (PMC) valve morphology should be comprehensively evaluated for mobility, thickness, calcifications, and subvalvular apparatus. The echo findings may determine the suitability for PMC, guide the procedure, and assess its results.
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Sahay, Sundeep, T. Sundararaman, and Jørn Braa. Public Health Informatics. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198758778.001.0001.

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Rapid and unpredictable developments in health policies, technologies, disease profiles, institutional environments, and their inter-connections have significant implications on how we design, develop, implement, and use health information systems (HIS) in low and middle-income countries (LMICs). Our current systems have heightened expectations but have proven largely incapable of meeting these new challenges. Nor have they been able to effectively leverage upon the new opportunities that are emerging, such as through the cloud, big data, the proliferation of mobile devices and the Internet of Things, and also the increasing array of new open source software solutions being made available through global development communities. What is required to try and address these challenges and opportunities? This book proposes the ‘Expanded PHI’ (public health informatics) perspective as a way forward, and through the various chapters first seeks to define it, and then apply it to analyse the following key problematics facing public health informatics in the domains of research, practice, and policy: use of information; integration of systems; leveraging cloud computing and big data; design and building of institutions that facilitate; managing complexity; evolving governance mechanisms and standards; responding to the new challenges thrown up by universal health coverage and Sustainable Development Goals; and building synergies between health systems strengthening and health information strengthening efforts. In defining the scope of Expanded PHI, the field of public health informatics is first situated within an informatics context, and then within public health and finally within the context of changing global health policies. Drawing from these contextualizations, the design principles for Expanded PHI are elucidated, based primarily on a social systems perspective, where the health of populations is kept as the central purpose and a participatory and incremental nature of change as the primary strategy.
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Steinberg, Martin, and Paul B. Rosenberg. The Office Assessment of Depression and Cognitive Impairment. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199959549.003.0002.

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Changes in mood and/or cognition are common complaints in the elderly population. This chapter uses case studies to illustrate insights to make clinical assessment more efficient. These include assessing for cognitive impairment when depression is present and vice versa, being mindful of assuming that patients reporting cognitive difficulties are “worried well,” avoiding overreaction to very mild symptoms, assessing the four key cortical cognitive domains (amnesia, aphasia, apraxia, agnosia), assessing for subcortical dysfunction, assessing Activities of Daily Living (ADLs) and Instrumental Activities of Daily Living (IADLs), and understanding that depression in the elderly often presents with atypical symptoms. Brief cognitive instruments which can improve assessment include the Mini Mental State Exam (MMSE), Montreal Cognitive Assessment (MoCA), Patient Health Questionnaire (PHQ), Clock Drawing Test (CDT), and the Mini Cog. Brief depression instruments include the Geriatric Depression Scale (GDSS), and Cornell Scale for Depression in Dementia (CSDD).
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Steinberg, Martin, Antonio N. Puente, and Cynthia A. Munro. The Role of Neuropsychological Examination. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199959549.003.0004.

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Changes in mood and/or cognition are common complaints in the elderly population. This chapter uses case studies to illustrate insights to make clinical assessment more efficient. These include assessing for cognitive impairment when depression is present and vice versa, being mindful of assuming that patients reporting cognitive difficulties are “worried well,” avoiding overreaction to very mild symptoms, assessing the four key cortical cognitive domains (amnesia, aphasia, apraxia, agnosia), assessing for subcortical dysfunction, assessing Activities of Daily Living (ADLs) and Instrumental Activities of Daily Living (IADLs), and understanding that depression in the elderly often presents with atypical symptoms. Brief cognitive instruments which can improve assessment include the Mini Mental State Exam (MMSE), Montreal Cognitive Assessment (MoCA), Patient Health Questionnaire (PHQ), Clock Drawing Test (CDT), and the Mini Cog. Brief depression instruments include the Geriatric Depression Scale (GDSS), and Cornell Scale for Depression in Dementia (CSDD).
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Book chapters on the topic "PhD domain"

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Salajegheh, Ali. "Prolyl Hydroxylase Domain-2 (PHD-2)." In Angiogenesis in Health, Disease and Malignancy. Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-28140-7_36.

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Werewka, Jan, and Michał Turek. "Computer Science PhD Program Evaluation Proposal Based on Domain and Non-domain Characteristics." In Information Systems Architecture and Technology: Proceedings of 36th International Conference on Information Systems Architecture and Technology – ISAT 2015 – Part III. Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-28564-1_15.

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De Angelis, Guglielmo, Alfonso Pierantonio, Andrea Polini, Barbara Re, Barbara Thönssen, and Robert Woitsch. "Modeling for Learning in Public Administrations—The Learn PAd Approach." In Domain-Specific Conceptual Modeling. Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-39417-6_26.

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Sukhoivanov, Igor A., and Igor V. Guryev. "Finite-Difference Time-Domain Method for PhC Devices Modeling." In Photonic Crystals. Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-642-02646-1_6.

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Chinesta, Francisco, and Elías Cueto. "Parametric Models in Evolving Domains." In PGD-Based Modeling of Materials, Structures and Processes. Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-06182-5_5.

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Meitzler, Jennifer L. "Purification and Characterization of DUOX Peroxidase Homology Domains (PHDs)." In Methods in Molecular Biology. Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-9424-3_4.

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Balech, Bachir, Alfonso Monaco, Michele Perniola, et al. "DNA Multiple Sequence Alignment Guided by Protein Domains: The MSA-PAD 2.0 Method." In Methods in Molecular Biology. Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-7683-6_13.

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Boudinar, Ahmed Hamida, Azeddine Bendiabdellah, and Noureddine Benouzza. "Diagnosis of the Broken Rotor Bars Faults by Root-MUSIC Method." In Advances in Computer and Electrical Engineering. IGI Global, 2019. http://dx.doi.org/10.4018/978-1-5225-6989-3.ch003.

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This chapter describes a new diagnosis approach, the Root-MUSIC (RM) method, for identification of the progressive cracking in the rotor of induction motors. This method used initially in the domain of RADAR for localizing mobile targets is being applied to the domain of induction motors diagnosis. This approach has several advantages compared to the conventional power spectral density estimation (PSD) by periodogram technique. Indeed, the main advantage of this approach is its very good frequency resolution for a very short acquisition time, something impossible to achieve with the conventional method. However, in order to reduce the computation time which is the main drawback of the RM method, this method will be applied to only a specified frequency band: one that carries information about the sought fault.
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Vinković, Maja, Andrijana Kopić, and Tvrtka Benašić. "Anti-VEGF Treatment and Optical Coherence Tomography Biomarkers in Wet Age-Related Macular Degeneration." In Recent Advances and New Perspectives in Managing Macular Degeneration [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.97689.

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Age-related macular degeneration (AMD) is one of the most common causes of severe visual loss in middle and old-age population, and often leads to serious deterioration in quality of life. Currently, the first-line treatment for neovascular AMD (nAMD) are intravitreal injections of anti-vascular endothelial growth factor (VEGF) medications, including bevacizumab, ranibizumab, and aflibercept and also latest commercially available drug, brolucizumab. During initial examination and imaging and treatment follow-up for patients with nAMD, optical coherence tomography (OCT) is used to predict and assess the therapeutic response and guide the treatment. Several OCT-based biomarkers, including the central subfoveal thickness (CSFT), the presence of intraretinal cysts (IRCs) or subretinal fluid (SRF), and the presence of pigment epithelial detachment (PED), were found to influence baseline visual acuity or visual improvements. Recent analyses of large randomized control trials (RCTs) summarized the usefulness of these OCT-based biomarkers. However, many of these early studies relied on time-domain OCT to evaluate the retinal structures thus providing less precise evaluation of the retinal details. After introduction of spectral-domain OCT (SD-OCT) which provided high resolution images, recent studies offered new insights in specific morphological changes and their different impact on visual function in nAMD. For example, these advancement in resolution offered new classification of IRCs into degenerative and exudative which impacts treatment strategy and final outcome in the treatment of nAMD. Moreover, the recent data disclose a substantial difference between RCTs and real-world studies regarding the response to anti-VEGF therapy. In conclusions, IRCs and PED are associated with poor visual improvement in nAMD in a realworld setting. Both IRCs and SRF responded better than PED to anti-VEGF therapy. These observations mandate large longitudinal studies focusing on the usefulness of these high resolution SD-OCT biomarkers in real-world situations.
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Sen, Salil K., and Junya K. Pookayaporn. "Towards a SDG Compliant Framework for the Open Learning Modules." In Open and Distance Learning Initiatives for Sustainable Development. IGI Global, 2018. http://dx.doi.org/10.4018/978-1-5225-2621-6.ch014.

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The implement-ability of the Sustainable Development Goals (SDGs) depend on effective Project Planning, Development &amp; Management (PPD&amp;M). This applied research bases on the extensive possibilities for open learning modules via distance education. The two-fold research gap addressed are content and delivery. Participants need a SDG-embedded Project Planning, Development and Management offering. This curriculum redesign initiative is in line with the book's aim to disseminate, sustain and continuously improve content and practice incorporating new tools, insights, methods, necessary for proper implementation of the SDGs. The re-designed content emphasizes the ability to inter-relate through appropriate tool-sets on challenges, priorities, themes, sectors in the project development management domain. Complex developmental concerns are best served when the participant deploys the right combination of tools. Need for re-look at the evaluation system is highlighted with an interesting proposal to engage PPD&amp;M alumni for continuous improvement on SDG-led growth.
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Conference papers on the topic "PhD domain"

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Mehta, Gayatri, and Alex K. Jones. "An architectural space exploration tool for domain specific reconfigurable computing." In Distributed Processing, Workshops and Phd Forum (IPDPSW). IEEE, 2010. http://dx.doi.org/10.1109/ipdpsw.2010.5470735.

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Yuhua Liu, Yuling Li, Laurence T. Yang, Naixue Xiong, Longquan Zhu, and Kaihua Xu. "The resource locating strategy based on sub-domain hybrid P2P network model." In Distributed Processing, Workshops and Phd Forum (IPDPSW). IEEE, 2010. http://dx.doi.org/10.1109/ipdpsw.2010.5470710.

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Talbot, Nick P., Tammie Bishop, Lynn G. Nicholls, et al. "A Role For Prolyl Hydroxylase Domain (PHD) Proteins In Respiratory Control." In American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado. American Thoracic Society, 2011. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a6371.

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Jin, Guanghao, Toshio Endo, and Satoshi Matsuoka. "A Multi-Level Optimization Method for Stencil Computation on the Domain that is Bigger than Memory Capacity of GPU." In 2013 IEEE International Symposium on Parallel & Distributed Processing, Workshops and Phd Forum (IPDPSW). IEEE, 2013. http://dx.doi.org/10.1109/ipdpsw.2013.58.

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Maeda, Toshikatsu, Masatoshi Watanabe, Seiji Takeda, and Shinichi Nakayama. "An Empirical Model to Determine the Modes of Corrosion of Carbon Steel Under Near Field Environments of Geological Disposal." In ASME 2010 13th International Conference on Environmental Remediation and Radioactive Waste Management. ASMEDC, 2010. http://dx.doi.org/10.1115/icem2010-40113.

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Carbon steel is an alloy that can be passivated and be attacked by localized corrosion under certain water chemistries. For example, it is known that carbon steel is passivated in solutions above pHd; the pH at general corrosion/passivation transition. In this study, an empirical model was developed to determine whether near field environments fall in the passivation or non-passivation domain for carbon steel. Using the experimental data obtained by previous studies, the pHd was defined as a function of four factors, where the activity of proton ion ([H+]) for pHd is assumed to be a linear combination of the logarithms of the total carbonate concentration ([C]), the chloride ion concentration ([Cl−]), the limiting current density of dissolved oxygen diffusion (iO2), and the inverse of absolute temperature of contacting solution (T). The derived equation fitted well with experimental data from previous studies.
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Pomadere, Marie, Erwan Liberge, Aziz Hamdouni, Elisabeth Longatte, and Jean-François Sigrist. "Numerical Study of Fluid-Structure Interactions in Tube Bundles With Multiphase-POD Reduced-Order Approach." In ASME 2012 11th Biennial Conference on Engineering Systems Design and Analysis. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/esda2012-82462.

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Fluid-Structure Interactions are present in a large number of systems of nuclear power plants and nuclear on-board stoke-holds. Particularly in steam generators, where tube bundles are submitted to cross-flow which can lead to structure vibrations. We know that numerical studies of such a complex mechanism is very costly, that is why we propose the use of reduced-order methods in order to reduce calculation times and to make easier parametric studies for such problems. We use the multiphase-POD approach, initially proposed by Liberge (E. Liberge; POD-Galerkin Reduction Models for Fluid-Structure Interaction Problems, PhD Thesis, Universite de La Rochelle, 2008). This method is an adaptation of the classical POD approach to the case of a moving structure in a flow, considering the whole system (fluid and structure) as a multiphase domain. We are interested in the case of large displacements of a structure moving in a fluid, in order to observe the ability of the multiphase-POD technique to give a satisfying solution reconstruction. We obtain very interesting results for the case of a single circular cylinder in cross-flow (lock-in phenomenon). Then we present the application of the method to a case of confined cylinders in large displacements too. Here again, results are encouraging. Finally, we propose to go further presenting a first step in parametric studies with POD-Galerkin approach. We only consider a flowing-fluid around a fixed structure and the Burgers’ equation. A future work will consist in applications to fluid-structure interactions.
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Sollima, Calogero, Gianni Petrangeli, Francesco D’Auria, and Jozef Misˇa´k. "Framework and Strategies for the Introduction of Best Estimate Models Into the Licensing Process." In 17th International Conference on Nuclear Engineering. ASMEDC, 2009. http://dx.doi.org/10.1115/icone17-75956.

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The current efforts to assure stable, safe and competitive operation of nuclear power plants go together with advances made in accident analysis domain where the deterministic safety analysis is an important instrument for confirming the adequacy and efficiency of provisions for the safety of nuclear power plants. Recently made advances offer two acceptable options for demonstrating that the safety is ensured with sufficient margin: use of best estimate (BE) computer codes either combined with conservative input data or with realistic input data but associated with evaluation of uncertainty of results. The objective, proposed for the present work, is the implementation of the best estimate plus uncertainty (BEPU) method into the licensing process, as developed by the University of Pisa in a PhD thesis. In the thesis activity, more emphasis is given to the study of “input and method” of BE calculations than on “uncertainty evaluation”. In the present paper, a summary of the results achieved is reported.
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Nogueira, Keiller, William Robson Schwartz, and Jefersson Alex Dos Santos. "Going Deep into Remote Sensing Spatial Feature Learning." In Conference on Graphics, Patterns and Images. Sociedade Brasileira de Computação, 2020. http://dx.doi.org/10.5753/sibgrapi.est.2020.12990.

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A lot of information may be extracted from the Earth’s surface through aerial images. This information may assist in myriad applications, such as urban planning, crop and forest management, disaster relief, etc. However, the process of distilling this information is strongly based on efficiently encoding the spatial features, a challenging task. Facing this, Deep Learning is able to learn specific data-driven features. This PhD thesis1 introduces deep learning into the remote sensing domain. Specifically, we tackled two main tasks, scene and pixel classification, using Deep Learning to encode spatial features over high-resolution remote sensing images. First, we proposed an architecture and analyze different strategies to exploit Convolutional Networks for image classification. Second, we introduced a network and proposed a new strategy to better exploit multi-context information in order to improve pixelwise classification. Finally, we proposed a new network based on morphological operations towards better learning of some relevant visual features.
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Hsiao, Tesheng, and Chung-Chiang Cheng. "Frequency Constrained Adaptive PID Laws for Motion Control Systems." In ASME 2017 Dynamic Systems and Control Conference. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/dscc2017-5108.

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The proportional-integral-derivative (PID) controller is widely used in motion control systems due to its simplicity and effectiveness. To achieve satisfactory performance, the PID parameters must be properly tuned. Although numerous PID tuning methods were investigated in the past, most of them were based on either time-domain or frequency-domain responses, while integration of features in both domains for PID tuning was less addressed. However, many industrial practitioners still found it difficult to compromise multiple conflicting control objectives, such as fast responses, small overshoot and tracking errors, and good robustness, with PID controllers. Moreover, it is desirable to adjust PID parameters online such that plant variations and unexpected disturbances can be compensated for more efficiently. In view of these requirements, this paper proposes an adaptive PID control law that updates its parameters online by minimizing the time-domain tracking errors subject to frequency-domain constraints that are imposed for loop shaping. By combining optimization criteria in both time and frequency domains for online parameter adjustment, the proposed PID controller can achieve good tracking performance with adequate robustness margin. Then the proposed PID law is applied to control an XZ-table driven by AC servo motors. Experimental results show that the tracking performance of the proposed controller is superior to that of a constant-gain PID controller whose parameters were tuned by the commercial Matlab/Simulink PID tuner.
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Waedt, Karl, Yongjian Ding, Antonio Ciriello, and Xinxin Lou. "Development, Distribution and Maintenance of Application Security Controls for Nuclear." In 2017 25th International Conference on Nuclear Engineering. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/icone25-67499.

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The generic concept of Security Controls, as initially deployed in the information security domain, is gradually used in other business domains, including industrial security for critical infrastructure and cybersecurity of nuclear safety I&amp;C. A Security Control, or less formally, a security countermeasure can be any organizational, technical or administrative measure that helps in reducing the risk imposed by a cybersecurity threat. The new IAEA NST036 lists more than 200 such countermeasures. NIST SP800-53 Rev. 4 contains about 450 pages of security countermeasure descriptions, which are graded according to three levels of stringency. In order to facilitate and formalize the process of developing, precisely describing, distributing and maintaining more complex security controls, the Application Security Controls (ASC) concept is introduced by the new ISO/IEC 27034 multipart standard. An ASC is an extensible semi-formal representation of a security control (e.g. XML or JSON-based), which contains a set of mandatory and optional parts as well as possible links to other ASCs. A set of Application Security Controls may be developed by one company and shipped together with a product of another company. ISO/IEC 27034-6 assumes that ASCs are developed by an organization or team specialized in security and that the ASCs are forwarded to customers for direct use or for integration into their own products or services. The distribution of ASCs is supported and formalized by the Organization Normative Frameworks (ONF) and Application Normative Frameworks (ANF) deployed in the respective organizational units. The maintenance and continuous improvement of ASCs is facilitated by the ONF Process and ANF Process. This paper will explore the applicability of these industry standards based ASC lifecycle concepts for the nuclear domain in line with IEC 62645, IEC 62859 and the up-coming IEC 63096. It will include results from an ongoing bachelor thesis and master thesis, mentored by two of the authors, as well as nuclear specific deployment scenarios currently being evaluated by a team of cybersecurity PhD candidates.
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Reports on the topic "PhD domain"

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Keleti, David. Identification of Novel Molecular Targets for Pleckstrin Homology (PH) Domains Found in Oncogenes Implicated in Breast Cancer. Defense Technical Information Center, 2008. http://dx.doi.org/10.21236/ada485939.

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Keleti, David. Identification of Novel Molecular Targets for Pleckstrin Homology (PH) Domains Found in Oncogenes Implicated in Breast Cancer. Defense Technical Information Center, 2005. http://dx.doi.org/10.21236/ada435560.

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Keleti, David. Investigation of Novel Molecular Targets for Pleckstrin Homology (PH) Domains Found in Oncogenes Implicated in Breast Cancer. Defense Technical Information Center, 2006. http://dx.doi.org/10.21236/ada455267.

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Keleti, David, and Mark A. Lemmon. Investigation of Novel Molecular Targets for Pleckstrin Homology (PH) Domains Found in Oncogenes Implicated in Breast Cancer. Defense Technical Information Center, 2007. http://dx.doi.org/10.21236/ada469536.

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