Journal articles: 'Phenanthroline-1,10(bis-(methyl-4 phenyl)-2,9)'

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Li, Peng-Peng, Li Zhao, Ji-Xing Zhao, Zhao-Bin Zhu, Fei Wang, and Qin-Qin An. "Synthesis and crystal structure of bis{1-(((4-(1-(hydroxyimino)ethyl)phenyl)imino)methyl)naphthalen-2-olato-κ2O,N}copper(II), C38H30CuN4O4." Zeitschrift für Kristallographie - New Crystal Structures 232, no. 6 (November 27, 2017): 889–90. http://dx.doi.org/10.1515/ncrs-2017-0044.

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AbstractC38H30CuN4O4, triclinic, P1̅ (no. 2), a = 8.3882(7) Å, b = 8.5024(9) Å, c = 11.3649(15) Å, α = 89.960(10)°, β = 69.689(10)°, γ = 80.269(8)°, Z = 1, V = 747.73(15) Å3, Rgt(F) = 0.0701, wRref(F2) = 0.1308, T = 294.68(10) K.

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Zang, Kai-Kai, Xiao Xiao, Li-Qiang Chen, Yan Yang, Qi-Lai Cao, Yu-Long Tang, Su-Su Lv, Hong Cao, Ling Zhang, and Yu-Qiu Zhang. "Distinct Function of Estrogen Receptors in the Rodent Anterior Cingulate Cortex in Pain-related Aversion." Anesthesiology 133, no. 1 (April 22, 2020): 165–84. http://dx.doi.org/10.1097/aln.0000000000003324.

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Background Brain-derived estrogen is implicated in pain-related aversion; however, which estrogen receptors mediate this effect remains unclear. This study hypothesized that the different estrogen receptors in the rostral anterior cingulate cortex play distinct roles in pain-related aversion. Methods Formalin-induced conditioned place avoidance and place escape/avoidance paradigms were used to evaluate pain-related aversion in rodents. Immunohistochemistry and Western blotting were used to detect estrogen receptor expression. Patch-clamp recordings were used to examine N-methyl-d-aspartate–mediated excitatory postsynaptic currents in rostral anterior cingulate cortex slices. Results The administration of the estrogen receptor-β antagonist 4-(2-phenyl-5,7-bis [trifluoromethyl] pyrazolo [1,5-a] pyrimidin-3-yl) phenol (PHTPP) or the G protein–coupled estrogen receptor-1 antagonist (3aS*,4R*,9bR*)-4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta [c] quinolone (G15) but not the estrogen receptor-α antagonist 1,3-bis (4-hydroxyphenyl)-4-methyl-5-[4-(2-piperidinylethoxy) phenol]-1H-pyrazole dihydrochloride (MPP) into the rostral anterior cingulate cortex blocked pain-related aversion in rats (avoidance score, mean ± SD: 1,3-bis [4-hydroxyphenyl]-4-methyl-5-(4-[2-piperidinylethoxy] phenol)-1H-pyrazole dihydrochloride (MPP): 47.0 ± 18.9%, 4-(2-phenyl-5,7-bis [trifluoromethyl] pyrazolo [1,5-a] pyrimidin-3-yl) phenol (PHTPP): −7.4 ± 20.6%, and [3aS*,4R*,9bR*]-4-[6-bromo-1,3-benzodioxol-5-yl]-3a,4,5,9b-3H-cyclopenta [c] quinolone (G15): −4.6 ± 17.0% vs. vehicle: 46.5 ± 12.2%; n = 7 to 9; P < 0.0001). Consistently, estrogen receptor-β knockdown but not estrogen receptor-α knockdown by short-hairpin RNA also inhibited pain-related aversion in mice (avoidance score, mean ± SD: estrogen receptor-α–short-hairpin RNA: 26.0 ± 7.1% and estrogen receptor-β–short-hairpin RNA: 6.3 ± 13.4% vs. control short-hairpin RNA: 29.1 ± 9.1%; n = 7 to 10; P < 0.0001). Furthermore, the direct administration of the estrogen receptor-β agonist 2,3-bis (4-hydroxyphenyl)-propionitrile (DPN) or the G protein–coupled estrogen receptor-1 agonist (±)-1-([3aR*,4S*,9bS*]-4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta [c]quinolin-8-yl)-ethanone (G1) into the rostral anterior cingulate cortex resulted in conditioned place avoidance (avoidance score, mean ± SD: 2,3-bis (4-hydroxyphenyl)-propionitrile (DPN): 35.3 ± 9.5% and (±)-1-([3aR*,4S*,9bS*]-4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta [c]quinolin-8-yl)-ethanone (G1): 43.5 ± 22.8% vs. vehicle: 0.3 ± 14.9%; n = 8; P < 0.0001) but did not affect mechanical or thermal sensitivity. The activation of the estrogen receptor-β/protein kinase A or G protein–coupled estrogen receptor-1/protein kinase B pathway elicited the long-term potentiation of N-methyl-d-aspartate–mediated excitatory postsynaptic currents. Conclusions These findings indicate that estrogen receptor-β and G protein–coupled estrogen receptor-1 but not estrogen receptor-α in the rostral anterior cingulate cortex contribute to pain-related aversion by modulating N-methyl-d-aspartate receptor–mediated excitatory synaptic transmission. Editor’s Perspective What We Already Know about This Topic What This Article Tells Us That Is New

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Ma, Jin-Xia, Qing-Lin Li, Peng-Peng Li, Ji-Xing Zhao, and Li Zhao. "Crystal structure of bis{5-methoxy-2-((E)-((4-((E)-1-(methoxyimino)ethyl)phenyl)imino)methyl)phenolato-κ2N,O}nickel(II), C34H34N4NiO6." Zeitschrift für Kristallographie - New Crystal Structures 233, no. 5 (August 28, 2018): 767–69. http://dx.doi.org/10.1515/ncrs-2017-0379.

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AbstractC34H34N4NiO6, monoclinic, P21/c (no. 14), a = 10.5538(5) Å, b = 6.1691(2) Å, c = 24.2831(9) Å, β = 100.519(4)°, Z = 2, V = 1554.43(11) Å3, Rgt(F) = 0.0402, wRref(F2) = 0.0973, T = 294.39(10) K.

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Zhang, Zi-Yang, Zhen-Zhong Huang, Yang Pan, and Cheng Song. "New transparent and thermally stable cardo poly(ether imide)s derived from 10,10-bis[4-(4-amino-2-pyridinoxy)phenyl]-9(10H)-anthrone." High Performance Polymers 32, no. 5 (October 23, 2019): 483–93. http://dx.doi.org/10.1177/0954008319883005.

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A new diamine bearing flexible ether, rigid pyridine, and bulky anthrone pendent group, 10,10-bis[4-(4-amino-2-pyridinoxy)phenyl]-9(10 H)-anthrone (BAPPA), was prepared in three steps from anthrone. BAPPA was reacted with six conventional aromatic dianhydrides in N, N-dimethylacetamide (DMAc) to form the corresponding new poly(ether imide)s (PEIs) via the poly(ether amic acid) (PEAA) precursors with inherent viscosities ranging from 0.85 dL g−1 to 1.26 dL g−1 and thermal imidization. All the PEAAs could be cast from DMAc solution and thermally converted into transparent, flexible, and tough PEI films with tensile strength of 72.2–112.4 MPa, tensile modulus of 1.8–2.1 GPa, and elongation at break of 10–18%. These PEIs were predominantly amorphous and displayed excellent thermal stability with the glass transition temperature of 290–388°C, the 5% weight loss temperature of 480–514°C, and the residue of 68–43% at 800°C in nitrogen. The PEIs derived from 1,4-bis(3,4-dicarboxyphenoxy)benzene dianhydride and 4,4′-hexafluoroisopropylidenediphathalic anhydride exhibited excellent solubility in organic solvents such as N-methyl-2-pyrrolidinone, DMAc, N, N-dimethylformamide, pyridine, and even in tetrahydrofuran. Meanwhile, these PEIs also exhibited high optical transparency with the ultraviolet cutoff wavelength in the 374–427 nm range and the wavelength of 80% transparency in the range of 468–493 nm.

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Krečmerová, Marcela, Hubert Hřebabecký, Milena Masojídková, and Antonín Holý. "Synthesis of 5-Phenyl-2(1H)-pyrimidinone Nucleosides." Collection of Czechoslovak Chemical Communications 61, no. 3 (1996): 458–77. http://dx.doi.org/10.1135/cccc19960458.

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Reaction of 2-phenyltrimethinium salt 1 with thiourea and subsequent reaction with chloroacetic acid afforded 5-phenyl-2(1H)-pyrimidinone (3). Its silyl derivative 4 was condensed with 1-O-acetyl-2,3,5-tri-O-benzoyl-D-ribofuranose under catalysis with tin tetrachloride or trimethylsilyl trifluoromethanesulfonate to give protected nucleoside 5 together with 5',O6-cyclo-5-phenyl-1,3-bis- (β-D-ribofuranosyl)-6-hydroxy-5,6-dihydro-2(1H,3H)-pyrimidinone (7). The greatest amounts of 7 were formed with the latter catalyst. Nucleosidation of the silyl derivative 4 with protected methyl 2-deoxy-D-ribofuranoside 8 or 2-deoxy-D-ribofuranosyl chloride 9 afforded 1-(2-deoxy-3,5-di-O-p-toluoyl-β-D-ribofuranosyl)-5-phenyl-2(1H)-pyrimidinone (10) and its α-anomer 11. Reaction of 10 and 11 with methanolic ammonia gave free 2'-deoxynucleosides 12 and 13. Compound 13 was converted into 5'-O-tert-butyldiphenylsilyl-3'-O-mesyl derivative 14 which on heating with 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) and subsequent cleavage with tetrabutylammonium fluoride afforded 2',3'-dideoxy-2',3'-didehydronucleoside 15. Reaction of the silyl derivative 4 with 1,2-di-O-acetyl-3,5-di-O-benzoylxylofuranose (18), catalyzed with tin tetrachloride, furnished 1-(2-O-acetyl-3,5-di-O-benzoyl-β-D-xylofuranosyl)-2(1H)-pyrimidinone (19) which was deprotected to give the β-D-xylofuranosyl derivative 22. As a side product, the nucleosidation afforded the β-D-xylopyranosyl derivative 23. Deacetylation of compound 19 gave 1-(3,5-di-O-benzoyl-β-D-xylofuranosyl)-5-phenyl-2(1H)-pyrimidinone (24) which on reaction with thionyl chloride afforded 2'-chloro-2'-deoxynucleoside 25 and 2',O6-cyclonucleoside 26. Heating of compound 25 with DBU in dimethylformamide furnished the lyxo-epoxide 27 which on reaction with methanolic ammonia was converted into free 1-(2,3-anhydro-β-D-lyxofuranosyl)-5-phenyl-2(1H)-pyrimidinone (28). Reaction of 1,2-di-O-acetyl-5-O-benzoyl-3-O-methanesulfonyl-D-xylofuranose (30) with silyl derivative 4 gave the nucleoside 31 which by treatment with DBU was converted into an equilibrium mixture of 5'-benzoylated arabinofuranoside 33a and its 2',6-anhydro derivative 33b.

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Zhou, Yu-Ting, Shou-Ri Sheng, Chuan-Chao Tang, Cheng Song, Zhen-Zhong Huang, and Xiao-Ling Liu. "Preparation and characterization of novel soluble polyarylates derived from 9,9-bis[4-(4-chloroformylphenoxy)phenyl]xanthene with various bisphenols." High Performance Polymers 30, no. 10 (November 30, 2017): 1203–9. http://dx.doi.org/10.1177/0954008317744869.

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A series of new polyarylates bearing cardo xanthene groups were synthesized by phase-transfer-catalyzed interfacial polycondensation of 9,9-bis[4-(4-chloroformylphenoxy)phenyl]xanthene with various bisphenols containing the isopropylidene, hexafluoroisopropylidene, 1-phenylethylidene, diphenylmethane, cyclohexane, and xanthene structures. High-molecular-weight polyarylates with number-average molecular weight and polydispersity index in the range of 30,100–35,300 and 1.82–2.17, respectively, exhibited high glass transition temperatures ranged from 226°C to 261°C, and their 10% weight loss temperatures were in the range of 421–452°C with char yields above 45% at 700°C in nitrogen. All the polyarylates were amorphous and readily soluble in organic solvents such as dichloromethane, chloroform, tetrahydrofuran, meta-cresol, pyridine, N,N-dimethylformamide, N,N-dimethylacetamide, and 1-methyl-2-pyrrolidinone at room temperature and could be cast into tough, transparent, and flexible films with tensile strengths of 85.6–108.3 MPa, elongations at break of 2–3%, and tensile moduli of 7–9 GPa.

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Luo, Yi-Sheng, Qiu-Ying Wang, Xue-Chun Mao, and Shou-Ri Sheng. "Synthesis and characterization of new cardo poly(ether amide)s containing 9(10H)-anthrone units." High Performance Polymers 32, no. 9 (May 11, 2020): 1001–9. http://dx.doi.org/10.1177/0954008320918922.

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A new aromatic diamine, 10,10-bis[4-(4-aminophenoxy)phenyl]-9(10 H)-anthrone (BAPA) has been synthesized from anthrone via three-step procedure. Direct phosphorylation polycondensation of BAPA with various aromatic dicarboxylic acids produced a series of cardo poly(ether amide)s with inherent viscosities of 0.97–1.29 dL g−1. All the polymers were readily soluble in polar solvents such as N-methyl-2-pyrrolidone, N, N-dimethylacetamide (DMAc), and pyridine at room temperature, and afforded transparent, strong, and flexible films upon casting from DMAc solvent. The resulting poly(ether amide)s had glass transition temperatures of 254–316°C, 10% weight loss temperatures of 495–524°C, and char yields of 55–70% at 800°C in nitrogen. These polymers were amorphous and their films exhibited tensile strengths of 81.6–104.7 MPa, tensile moduli of 1.8–2.4 GPa, and elongations at break of 8–15%.

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Ghorab, Mostafa M., Mansour S. Al-Said, and Reem K. Arafa. "Design, Synthesis and Potential Anti-Proliferative Activity of Some Novel 4-Aminoquinoline Derivatives." Acta Pharmaceutica 64, no. 3 (September 1, 2014): 285–97. http://dx.doi.org/10.2478/acph-2014-0030.

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Abstract Novel nineteen compounds based on a 4-aminoquinoline scaffold were designed and synthesized as potential antiproliferative agents. The new compounds were N-substituted at the 4-position by aryl or heteroaryl (1-9), quinolin- 3-yl (10), 2-methylquinolin-3-yl (11), thiazol-2-yl (12), and dapsone moieties (13, 14 and 18). Bis-compounds 15, 16 and 19 were also synthesized to assess their biological activity. All the newly synthesized comounds were tested for in vitro antiproliferative activity against the MCF-7 breast cancer cell line. Seventeen of the novel compounds showed higher activity than the reference drug doxorubicin. The corresponding 7-(trifluoromethyl)-N-(3,4,5-trimethoxyphenyl)quinolin-4- amine 1, N-(7-(trifluoromethyl)quinolin-4-yl)quinolin- 3- amine (10), 2-methyl-N-(7-trifluorome-thyl)quinolin-4-yl) quinolin-3-amine (11) and N-(4-(4-aminophenylsulfonyl) phenyl)-7-chloroquinolin-4-amine (13) were almost twice to thrice as potent as doxorubicin. Biological screening of the tested compounds could offer an encouraging framework in this field that may lead to the discovery of potent anticancer agents.

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Weni, Mustika, Mega Safithri, and Djarot Sasongko Hami Seno. "Molecular Docking of Active Compounds Piper crocatum on the A-Glucosidase Enzyme as Antidiabetic." Indonesian Journal of Pharmaceutical Science and Technology 7, no. 2 (July 11, 2020): 64. http://dx.doi.org/10.24198/ijpst.v7i2.21120.

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Ethanol extract of Piper crocatum leaves has inhibitory activity of α-glucosidase enzyme. Ethyl acetate fraction from Piper crocatum leaves has the highest antioxidant activity. Previous research has provided information that the ethyl acetate fraction of Piper crocatum leaves has an inhibition of α-glucosidase containing 6XO32ZSP1D, Ethyl L-serinate hydrochloride compound, Schisandrin B compound, Columbin compound, 4- (4-methoxy-phenylamino) -2 compound, 3-dihydro-1H-4a, 9-diazacyclopenta (b) fluorine-10-carbonitrile, compound 6-Amino-4- [3- (benzyloxy) phenyl] -3-tert-butyl-2,4-dihydropyrano [2, 3-c] pyrazole-5-carbonitrile, compound 4 - {{4.6-Bis [(3R, 5S) -3,5-diamino-1-piperydinyl] -1,3,5-triazine-2-yl} amino) benzenesulfonamide and compound 1.1 '- (1,4-butanediyl) bis {2,6-dimethyl-4 - [(3-methyl-1,3-benzothiazol-2 (3H) ylidene) methyl] pyridinium. This study aims to study the interaction between bioactive compounds contained in ethyl acetate fraction of Piper crocatum leaves with α-glucosidase enzyme in In Silico using AutoDock Vina, Columbin shows the lowest binding energy with binding sites with amino acids Ser240, Asp242, His280, Arg315, Glu411, Phe159, Arg442, Tyr158 and Phe303. Columbin has the stability and inhibits the α-glucosidase enzyme from S. cerevisiae better than the seven other compounds, because it has OH and CH3 groups which play a role in the interaction with around the active side of the α-glucosidase enzyme.Keywords: Columbin, In Silico, α-Glucosidase

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Bertolasi, V., P. Gilli, V. Ferretti, and G. Gilli. "Intermolecular N-H...O Hydrogen Bonding Assisted by Resonance. II. Self Assembly of Hydrogen-Bonded Secondary Enaminones in Supramolecular Catemers." Acta Crystallographica Section B Structural Science 54, no. 1 (February 1, 1998): 50–65. http://dx.doi.org/10.1107/s0108768197008677.

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The crystal structures of 15 compounds containing the 2-en-3-amino-1-one heterodienic system and forming intermolecular N—H...O hydrogen bonds assisted by resonance (RAHB) are reported: (1) 3-phenylamino-2-cyclohexen-1-one; (2) 3-(4-methoxyphenylamino)-2-cyclohexen-1-one; (3) 3-(4-chlorophenylamino)-2-cyclohexen-1-one; (4) 3-(4-methoxyphenylamino)-2-methyl-2-cyclohexen-1-one; (5) 3-(4-methoxyphenylamino)-5-methyl-2-cyclohexen-1-one; (6) 3-isopropylamino-5,5-dimethyl-2-cyclohexen-1-one; (7) 3-phenylamino-5,5-dimethyl-2-cyclohexen-1-one; (8) 3-(3-methoxyphenylamino)-5,5-dimethyl-2-cyclohexen-1-one; (9) N,N-3-aza-pentane-1,5-bis[1-(3-oxo-5,5-dimethyl-1-cyclohexenyl)]; (10) 3-phenylamino-6,6-dimethyl-2-cyclohexen-1-one; (11) 3-(2-methoxyphenylamino)-6,6-dimethyl-2-cyclohexen-1-one; (12) 3-(3-chlorophenylamino)-6,6-dimethyl-2-cyclohexen-1-one; (13) 3-(4-chlorophenylamino)-6,6-dimethyl-2-cyclohexen-1-one; (14) 1-(4-chlorophenyl)-4-(4-chlorophenylamino)-6-methyl-2-pyridone; (15) 3-(4-chlorophenylamino)-5-phenyl-2-cyclopenten-1,4-dione. All compounds form intermolecular N—H...O=C hydrogen bonds assisted by resonance connecting the heteroconjugated enaminonic groups in infinite chains. Chain morphologies are analyzed to find out crystal engineering rules able to predict and interpret the crystal packing. Simple secondary enaminones [i.e. (1)–(13) together with a number of structures retrieved from the Cambridge Structural Database] are found to form hydrogen bonds having π-delocalizations, as characterized by a C=O bond-length average of 1.239 ± 0.004 Å, and hydrogen-bond strengths, represented by the N...O average distance of 2.86 ± 0.05 Å, very similar to those previously found for amides. Enaminones, however, can be easily substituted by chemical groups able to influence both π-conjugations and N...O hydrogen-bond distances. Some substituted enaminones, retrieved from the literature, display, in fact, N...O hydrogen-bond distances as short as 2.627 Å and large π-delocalizations with C=O double-bond distances as long as 1.285 Å. These effects appear to be associated with (a) the presence of further π-conjugated systems involving the C=O and NH groups of the enaminone moiety or (b) the transformation of the enaminone carbonyl group in an amidic function.

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Herberhold, Max, Christian Köhler, Volker Tröbs, and Bernd Wrackmeyer. "Tri(Terf-Butyl)plumbyl-phosphanes, Synthesis and Multinuclear Magnetic Resonance." Zeitschrift für Naturforschung B 55, no. 10 (October 1, 2000): 939–45. http://dx.doi.org/10.1515/znb-2000-1008.

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AbstractThe reaction of tri(tert-butyl)plumbyl-lithium (1) with various phosphorus chlorides was studied. With diphenyl- and amino(phenyl)phosphorus chlorides the formation of hexa(tertbutyl) diplumbane (2) and tetraphenyldiphosphane (3) or the respective 1,2-bis(am ino)-1,2-diphenyl- diphosphanes [e. g. 5: amino = PhCH2(tBu)N] was dominant. The presence of at least one tert-butyl group at the phosphorus atom gave access to tri(tert-butyl)plumbyl-di(tert-butyl) phosphane (4) and to tri(tert-butyl)plumbyl-amino(tert-butyl)phosphanes [amino = tBu(H)N (6), Me(Ph)N (7), PhCH2(Me)N (8), PhCH2(tBu)N (9)] via the reaction of 1 with the corresponding phosphorus chlorides. Side products were again 2 and the corresponding diphosphanes, unidentified compounds, and in two cases, bis(phosphanyl)-di(tert-butyl)plumbanes [phosphanyl = tBu(H)N(tBu)P (10), Me(Ph)N(tBu)P (11)]. Trimethylplumbyl-benzyl(methyl)- amino(tert-butyl)phosphane (12) was prepared for comparison. All compounds were characterized by their 1H , 13C, 15N (9 ),31P and 207Pb NMR data. The coupling constants 1J(207Pb,31P) are large and negative, whereas the coupling constants 1J(207Pb, 13C) are small and can be of either sign. The coupling constants 2J(31P-N-13C) of 6 - 12 indicate a preferred conformation of the substituents at phosphorus and nitrogen

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McGlinchey, Michael J., and Kirill Nikitin. "Palladium-Catalysed Coupling Reactions En Route to Molecular Machines: Sterically Hindered Indenyl and Ferrocenyl Anthracenes and Triptycenes, and Biindenyls." Molecules 25, no. 8 (April 22, 2020): 1950. http://dx.doi.org/10.3390/molecules25081950.

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Pd-catalysed Stille and Suzuki cross-couplings were used to prepare 9-(3-indenyl)-, 6, and 9-(2-indenyl)-anthracene, 7; addition of benzyne led to the 9-Indenyl-triptycenes, 8 and 9. In 6, [4 + 2] addition also occurred to the indenyl substituent. Reaction of 6 through 9 with Cr(CO)6 or Re2(CO)10 gave their M(CO)3 derivatives, where the Cr or Re was complexed to a six- or five-membered ring, respectively. In the 9-(2-indenyl)triptycene complexes, slowed rotation of the paddlewheel on the NMR time-scale was apparent in the η5-Re(CO)3 case and, when the η6-Cr(CO)3 was deprotonated, the resulting haptotropic shift of the metal tripod onto the five-membered ring also blocked paddlewheel rotation, thus functioning as an organometallic molecular brake. Suzuki coupling of ferrocenylboronic acid to mono- or dibromoanthracene yielded the ferrocenyl anthracenes en route to the corresponding triptycenes in which stepwise hindered rotations of the ferrocenyl groups behaved like molecular dials. CuCl2-mediated coupling of methyl- and phenyl-indenes yielded their rac and meso 2,2′-biindenyls; surprisingly, however, the apparently sterically crowded rac 2,2′-Bis(9-triptycyl)biindenyl functioned as a freely rotating set of molecular gears. The predicted high rotation barrier in 9-phenylanthracene was experimentally validated via the Pd-catalysed syntheses of di(3-fluorophenyl)anthracene and 9-(1-naphthyl)-10-phenylanthracene.

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Duarte, Mônica Oliveira, Soraia Lunardelli, Cíntia Janine Kiekow, Ana Cristina Stein, Liz Müller, Eveline Stolz, Stela Maris Kuze Rates, and Grace Gosmann. "Phloroglucinol Derivatives Present an Antidepressant-like Effect in the Mice Tail Suspension Test (TST)." Natural Product Communications 9, no. 5 (May 2014): 1934578X1400900. http://dx.doi.org/10.1177/1934578x1400900522.

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The antidepressant-like effects of phloroglucinol and seven synthetic related derivatives were investigated using the tail suspension test (TST) in mice. Compounds 2-methyl-1-[2,4,6-trihydroxy-3-(2-methylpropanoyl)phenyl] propan-1-one (5), 1-(2,4,6-trihydroxyphenyl)ethan-1-one (6), 1-(3-acetyl-2,4,6-trihydroxyphenyl)ethan-1-one (7), 2-methyl-1-[2,4,6-trihydroxy-3-(2-methylpropanoyl)-5-{[2,4,6-trihydroxy-3,5-bis(2-methylpropanoyl)phenyl]methyl} phenyl] propan-1-one (9) and 1-{3-acetyl-5-[(3,5-diacetyl-2,4,6-trihydroxyphenyl)methyl]-2,4,6-trihydroxyphenyl}ethan-1-one (10), containing acyl groups, decreased the immobile behavior of mice treated orally with equimolar doses of imipramine 20 mg/kg, with no alterations in locomotor activity as assessed by the open-field test. These results suggest that these phloroglucinol derivatives could represent a new molecular model in the search for antidepressant drugs.

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Heuer, Lutz, Ulrike K. Bode, Peter G. Jones, and Reinhard Schmutzler. "Cyclopentadienyldifluorphosphin und Homologe als Liganden in cis-Dichloroplatin(II)-Komplexen — Struktur von cis-(C5Me5PF2)2PtCl2 und cis-(C9H7PF2)[(C9H7)3P]PtCl2 (C5Me5 = Pentamethylcyclopentadienyl, C9H7 = Indenyl) / Cyclopentadienyldifluorophosphine and its Homologues as Ligands in cis-Dichloroplatinum(II) Complexes — Structure of cis-(C5Me5PF2)2PtCl2 and cis-(C9H7PF2)[(C9H7)3P]PtCl2 (C5Me5 = Pentamethylcyclopentadienyl, C9H7 = Indenyl)." Zeitschrift für Naturforschung B 44, no. 9 (September 1, 1989): 1082–92. http://dx.doi.org/10.1515/znb-1989-0915.

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Derivatives of cyclopentadienyldifluorophosphine. e. g. CpPF2 (1), Cp*PF2 (Cp* = C5Me5) (2),1-(indenyl)PF2 (3), 9-(fluorenyl)PF2 (4), 1-(ferrocenyl)PF2 (5), 1,1′-(ferrocenyl)(PF2)2 (6) and also 1-N-phenyl-2-difluorophosphinopyrrole (7) were prepared using the reaction of the appropriate organolithium compound and PF2Cl. Their reactivity towards cis-dichloro-(η4-cyclooctadiene)-platinum(II) and tetracyanoethylene was investigated. The complexes poly-dichloro-bis-(cyclopentadienyldifluorophosphine)platinum(II) (8), cis-dichloro-bis-(pentamethylcyclopentadienyldifluorophosphine)platinum(II) (9), cis-dichloro-(3-indenyldifluorophosphine)(di(1-indenyl)-3-indenylphosphine)platinum(II) (10), cis-dichloro-bis-(9-fluorenyldifluorophosphine)platinum(II) (11) and cis-dichloro-bis-(1-N-phenyl-2-difluorophosphinopyrrole)platinum(II) (12) were prepared. 10 is the first mixed organodifluorophosphine-triarylphosphine-platinum(II)-complex. The structures of 9 and 10 were determined by X-ray crystal structure analyses. 9 crystallizes in the monoclinic space group, P21/c with cell constants a = 835.3(2), b = 1479.0(3), c = 2071.7(4) pm, β = 99.67(2)° and Z = 4; R = 0.038 for 4760 unique observed reflections. The bonds to platinum are all short; Pt—P 220.3, 219.8(1), Pt—Cl 231.7, 231.9(2) pm. 10 crystallizes as a toluene hemisolvate in the monoclinic space group, P21/n, with cell constants a = 1225.7(5), b = 995.0(3), c = 2886.3(10) pm, β = 90.83° and Z = 4; R = 0.074 for 2664 unique observed reflections. The precision was poor, but the unexpected presence of both 1- and 3-indenyl groups was unambiguously demonstrated.

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15

Lamač, Martin, Ivana Císařová, and Petr Štěpnička. "Stereoselective Methylation of 1-(Diphenylphosphanyl)-2-[(methoxycarbonyl)methyl]ferrocene. The Crystal Structures of the Methylated Ester and Its Palladium(II) Complex with an Auxiliary 2-[(Dimethylamino)methyl]phenyl Ligand." Collection of Czechoslovak Chemical Communications 72, no. 8 (2007): 985–95. http://dx.doi.org/10.1135/cccc20070985.

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Treatment of racemic 1-(diphenylphosphanyl)-2-[(methoxycarbonyl)methyl]ferrocene successively with NaN(SiMe3)2 and methyl iodide affords the C-alkylated product, 1-(diphenylphosphanyl)-2-[1-(methoxycarbonyl)ethyl]ferrocene (6), as a mixture of diastereoisomers in ca. 10:1 ratio, from which the major (S,Rp/R,Sp)-diastereoisomer is easily isolated by crystallisation. (S,Rp/R,Sp)-6 reacts with [Pd(LNC)(MeCN)2]ClO4 (LNC = 2-[(dimethylamino-κN)- methyl]phenyl-κC1) to give the cationic bis-chelate complex (S,Rp/R,Sp)-[Pd(LNC)(6-κ2O,P)]- ClO4 (9). The structures of (S,Rp/R,Sp)-6 and 9 have been determined by single-crystal X-ray diffraction. Hydrolysis of ester 6 to the corresponding carboxylic acid proved to be difficult, being complicated by racemisation at the chiral carbon atom and oxidation of the phosphanyl group.

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16

Gross, Thoralf, Helmut Reinke, and Hartmut Oehme. "Geminal bis(hypersilyl) compounds the synthesis and structure of bis[tris(trimethylsilyl)silyl]silanes." Canadian Journal of Chemistry 78, no. 11 (November 1, 2000): 1399–404. http://dx.doi.org/10.1139/v00-136.

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Protodesilylation of diphenylsilane with trifluoromethanesulfonic acid and subsequent reaction of the obtained bis(trifluoromethanesulfonyloxy)silane with tris(trimethylsilyl)silyllithium (1) (molar ratio 1:2) afforded bis[tris(trimethylsilyl)silyl]silane (8). Methyl-bis[tris(trimethylsilyl)silyl]silane (3) and phenyl-bis[tris(trimethylsilyl)silyl]silane (10) were obtained by coupling reactions of 1 with MeHSiCl2 or PhHSiCl2, respectively, (2:1). By treatment with HCBr3, the H-silanes 3, 8, and10 were converted into the bromosilanes [(Me3Si)3Si]2SiR1R2 (9: R1 = R2 = Br; 11: R1 = Me, R2 = Br; 12: R1 = Ph, R2 = Br). X-ray crystal structure analyses, performed for 3, 10 and 12, confirmed the expected distortions of the molecular skeletons of the compounds. Thus, e.g., in 10, the spatial demand of the two extended hemispherical hypersilyl groups forces a widening of the Si-Si-Si angle at the central Si atom to a value of 128.3°.Key words: silanes, sterically congested, bis(hypersilyl)silanes, hypersilylsilanes, bis(hypersilyl)germanes, tris(trimethylsilyl)silylsilanes.

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17

Son, Kyung-sun, Jeong Oh Woo, Daeyoung Kim, and Sung Kwon Kang. "Crystal structure of dichlorido{2,6-bis[(3-phenyl-1H-pyrazol-1-yl)methyl]pyridine}cobalt(II)." Acta Crystallographica Section E Crystallographic Communications 71, no. 4 (March 4, 2015): m75—m76. http://dx.doi.org/10.1107/s2056989015003862.

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In the title complex, [CoCl2(C25H21N5)], the CoIIatom is coordinated by two Cl atoms and two N atoms, provided by a tridentate pyrazolylpyridyl ligand, forming a slightly distorted tetrahedral geometry [range of angles: 96.51 (10) (chelate ring) to 118.60 (9)°]. The dihedral angle between Cl/Co/Cl and N/Co/N planes is 86.83 (7)°. The chelate ring has the conformation of a distorted boat. The dihedral angle between pyridyl ring and the coordinated pyrazolyl ring is 56.16 (12)°. The uncoordinated pyrazolyl ring is almost perpendicular to the pyridyl ring with the dihedral angle of 87.49 (10)°. In the crystal packing, intermolecular phenyl-C—H ...π(pyridyl) interactions generate dimeric aggregates. These are connected into a zigzag supramolecular chain along thec-axis directionviaπ–π interactions [inter-centroid distance between pyridyl and phenyl rings = 3.664 (2) Å].

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18

Wang, Boyang, and Jian Wang. "Crystal structure of poly[bis(μ2-bis(4-(1H-imidazol-1-yl)phenyl)amine-κ2N:N′)-bis(nitrato-κO)cadmium(II)], C36H30CdN12O6." Zeitschrift für Kristallographie - New Crystal Structures 234, no. 5 (September 25, 2019): 927–28. http://dx.doi.org/10.1515/ncrs-2019-0150.

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19

Ghani, Nurunajah Ab, Nor Hadiani Ismail, Yoshiaki Noma, and Yoshinori Asakawa. "Microbial Transformation of Some Natural and Synthetic Aromatic Compounds by Fungi: Aspergillus and Neurospora Strains." Natural Product Communications 12, no. 8 (August 2017): 1934578X1701200. http://dx.doi.org/10.1177/1934578x1701200822.

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Microbial transformation of chalcone (1), 4-hydroxychalcone (2) and 4′-hydroxychalcone (3), 1,1-diphenylmethane (4), 1,3-diphenylacetone (5), 1,3-diphenylpropane (6), bibenzyl (7), ( E)-stilbene (8a)- and ( Z)-stilbenes (8b), and phenylcyclohexane (9), (1 R,2 S)-1-phenyl-2-hydroxycyclohexane (9a) and (1 S,2 R)-1-phenyl-2-hydroxycyclohexane (9b), and a naturally occurring bis-bibenzyl, marchantin A (10) were performed by using Aspergillus niger TBUYN-2 and the other Aspergillus strains, and Neurospora crassa which were capable to hydrogenation and epoxidation of a conjugated double bond, and direct hydroxylation and hydroperoxidation on benzene ring, and hydroxylation and carbonization on cyclohexane ring. Aspergillus species converted chalcone (1) to dihydrochalcone (1a) almost quantitatively.

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20

Park, Jinho, Beomsu Jang, Yu Ji Moon, Hakjun Lee, Young Kwan Kim, and Seung Soo Yoon. "Deep Blue Organic Light-Emitting Diodes Based on [7,7-Dimethyl-9-(10-phenylanthracen-9-yl)-7H-Indeno[1,2-f] Isoquinoline] Derivatives." Journal of Nanoscience and Nanotechnology 20, no. 11 (November 1, 2020): 6648–52. http://dx.doi.org/10.1166/jnn.2020.18759.

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In this study, we synthesized and characterized two novel deep blue emitting materials based on indenoquinoline-substituted phenylanthracene derivatives. Multilayer organic light-emitting diodes were fabricated with the following sequence: indium-tin-oxide (ITO)/4,4′,4″-tris[2-naphthyl(phenyl)amino (2-TNATA)/4,4′-bis(N-N-naphthyl)-N-phenylamino) biphenyl (NPB)/Blue emitting material (1 or 2)/Bathophenanthroline (Bphen)/lithium quinolate (Liq)/Al. A device B using ‘7,7-dimethyl-9-(10-phenylanthracen-9-yl)-7H-indeno[1,2-f] isoquinoline (2)’ as an emitter showed the efficient emission with the luminous efficiency, power efficiency, and external quantum efficiency of 2.30 cd/A, 1.02 lm/W, 2.94% at 20 mA/cm2, respectively. This device exhibited deep-blue emission with the Commission Internationale De LÉnclairage (CIE) coordinates of (0.16, 0.08) and λmax = 436 nm at 8.0 V.

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21

Deacon, GB, MJ Oconnor, and GN Stretton. "Organomercury Compounds .XXVIII. The Synthesis and 199Hg N.M.R-Spectra of Some Unsymmetrically Dimercurated Arenes." Australian Journal of Chemistry 39, no. 7 (1986): 953. http://dx.doi.org/10.1071/ch9860953.

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Mercuration of 1-methoxy-2-nitrobenzene (1) with mercuric trifluoroacetate (mole ratio 1 : 1) in trifluoroacetic acid yields 1- methoxy-2-nitro-4-(trifluoroacetatomercurio)benzene (2). With a 1 : 2 mole ratio, (2) and 1-methoxy-2-nitro-4,6- bis(trifluoroacetatomercurio)benzene (3) are obtained, and, with a 1:4 ratio, (3) and a little 1-methoxy-2-nitro-3,4- bis(trifluoroacetatomercurio)benzene (4). are obtained. 2-Nitrophenol (5) with mercuric trifluoroacetate (mole ratio 1 : 2) gives 2-nitro- 4,6-bis(trifluoroacetatomercurio)phenol (6), and vanillin (7) yields 5,6-bis(trifluoroacetatomercurio)vanillin (8). Compound (8) has been converted into 5,6-di(chloromercurio)- and 5,6- di(bromomercurio)vanillin [(9) and (10)]. 199Hg,199Hg spin-spin coupling constants have been determined s 6500-8200 Hz for 3JHg,Hg of (8)- (10), 2100-2200 Hz for 4JHg,Hg of (3) and (6), and 858 Hz for 5JHg,Hg of 4- methoxy-2,5-bis(trifluoroacetatomercurio)benzoic acid (11).

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22

Thokchom, Herojit S., Anita D. Nongmeikapam, and Warjeet S. Laitonjam. "Synthesis of fused pyrazolo-, isoxazolo-, pyrimido-, and pyridopyrimidines." Canadian Journal of Chemistry 83, no. 8 (August 1, 2005): 1056–62. http://dx.doi.org/10.1139/v05-054.

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A systematic study of the synthesis of the 5,7-diaryl-4-oxo-pyrazolo[3,4-d]pyrimidin-6-thiones (3), 2-phenyl-5,7-bis(2′-methylphenyl)-4-oxo-pyrazolo[3,4-d]pyrimidin-6-thiones (4b), 2(3H)-3-phenyl-5,7-diaryl-4-oxo-pyrazolo[3,4-d]pyrimidin-6-thiones (5), 5,7-diaryl-4-oxo-isoxazolo[5,4-d]pyrimidin-6-thiones (7), 3,5,7-triaryl-2,3-dihydro-4-oxo-isoxazalo[5,4-d]pyrimidin-6-thiones (8), 2-amino-6,8-diaryl-5-oxo-pyrimido[4,5-d]pyrimidin-7-thiones (9), 3,4-dihydro-2-amino-4-phenyl-6,8-diaryl-5-oxo-pyrimido[4,5-d]pyrimidin-7-thiones (10), 3-cyano-6,8-diaryl-2,5-dioxo-pyrido[2,3-d]pyrimidin-7-thiones (11) from the condensation products 1 and 2, derived from 1,3-diaryl-2-thiobarbituric acids is described.Key words: synthesis, fused, pyrazole, isoxazole, pyrimidines.

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23

Siddiqui, Bina Shaheen, Munawwer Rasheed, Firdous Ilyas, Tahsin Gulzar, Rajput Mohammad Tariq, and Syed Naim-ul-Hassan Naqvi. "Analysis of Insecticidal Azadirachta indica A. Juss. Fractions." Zeitschrift für Naturforschung C 59, no. 1-2 (February 1, 2004): 104–12. http://dx.doi.org/10.1515/znc-2004-1-221.

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As a result of chemical investigation on the ethanolic extract of fresh fruit coatings of Azadirachta indica A. Juss. (neem), twenty-seven compounds were identified in non-polar to less polar fractions which showed pesticidal activity determined by WHO method against Anopheles stephensi Liston. These identifications were basically made through GC-EIMS and were further supported by other spectroscopic techniques, including 13C NMR, UV and FTIR as well as retention indices. Thus sixteen n-alkanes, 1-16; three aromatics 2,6-bis-(1,1- dimethylethyl)-4-methyl phenol (17), 2-(phenylmethylene)-octanal (20), 1,2,4-trimethoxy-5- (1Z-propenyl)-benzene (27); three benzopyranoids 3,4-dihydro-4,4,5,8-tetramethylcoumarin (18), 3,4-dihydro-4,4,7,8-tetramethylcoumarin-6-ol (19), 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethyl- cyclopenta[g]-2-benzopyran (22); one sesquiterpene methyl-3,7,11-trimethyl-2E,- 6E,10-dodecatrienoate (21); three esters of fatty acids methyl 14-methyl-pentadecanoate (23), ethyl hexadecanoate (24), ethyl 9Z-octadecenoate (25) and one monoterpene 3,7-dimethyl- 1-octen-7-ol (26) were identified. Except 6, 8, 24 and 25 all these compounds were identified for the first time from the pericarp and fifteen of these, 1-3, 7, 9, 10, 17-23, 26, 27, are hitherto unreported previously from any part of the tree. Although this tree is a rich source of various natural products, it is the first report of identification of mono- and sesquiterpenes 26 and 21 and a potent antioxidant, 17.

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24

Mao, Meng-Xi, Fang-Ling Li, Yan Shen, Qi-Ming Liu, Shuai Xing, Xu-Feng Luo, Zhen-Long Tu, Xue-Jun Wu, and You-Xuan Zheng. "Simple Synthesis of Red Iridium(III) Complexes with Sulfur-Contained Four-Membered Ancillary Ligands for OLEDs." Molecules 26, no. 9 (April 29, 2021): 2599. http://dx.doi.org/10.3390/molecules26092599.

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Phosphorescent iridium(III) complexes have been widely researched for the fabrication of efficient organic light-emitting diodes (OLEDs). In this work, three red Ir(III) complexes named Ir-1, Ir-2, and Ir-3, with Ir-S-C-S four-membered framework rings, were synthesized efficiently at room temperature within 5 min using sulfur-containing ancillary ligands with electron-donating groups of 9,10-dihydro-9,9-dimethylacridine, phenoxazine, and phenothiazine, respectively. Due to the same main ligand of 4-(4-(trifluoromethyl)phenyl)quinazoline, all Ir(III) complexes showed similar photoluminescence emissions at 622, 619, and 622 nm with phosphorescence quantum yields of 35.4%, 50.4%, and 52.8%, respectively. OLEDs employing these complexes as emitters with the structure of ITO (indium tin oxide)/HAT-CN (dipyra-zino[2,3-f,2′,3′-h]quinoxaline-2,3,6,7,10,11-hexacarbonitrile, 5 nm)/TAPC (4,4′-cyclohexylidenebis[N,N-bis-(4-methylphenyl)aniline], 40 nm)/TCTA (4,4″,4″-tris(carbazol-9-yl)triphenylamine, 10 nm)/Ir(III) complex (10 wt%): 2,6DCzPPy (2,6-bis-(3-(carbazol-9-yl)phenyl)pyridine, 10 nm)/TmPyPB (1,3,5-tri(mpyrid-3-yl-phenyl)benzene, 50 nm)/LiF (1 nm)/Al (100 nm) achieved good performance. In particular, the device based on complex Ir-3 with the phenothiazine unit showed the best performance with a maximum brightness of 22,480 cd m−2, a maximum current efficiency of 23.71 cd A−1, and a maximum external quantum efficiency of 18.1%. The research results suggest the Ir(III) complexes with a four-membered ring Ir-S-C-S backbone provide ideas for the rapid preparation of Ir(III) complexes for OLEDs.

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25

Arnold, Donald R., Brian J. Fahie, Laurie J. Lamont, Jacek Wierzchowski, and Kent M. Young. "1,n-Radical ions. The photosensitized (electron transfer) formation of 1,5-radical cations." Canadian Journal of Chemistry 65, no. 12 (December 1, 1987): 2734–43. http://dx.doi.org/10.1139/v87-455.

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The photosensitized (electron transfer) reactions of 3-phenyl-2,3-dihydrobenzofuran (8a), 5-methyl-3-phenyl-2,3-dihydrobenzofuran (8b), cis and trans-2-methoxy-1-phenylindane (9, cis and trans), 3,3-diphenyltetrahydrofuran (10), and 2,2-diphenyl-1-methoxycyclopentane (11) have been studied using 1,4-dicyanobenzene as an electron-accepting photosensitizer and acetonitrile–methanol (3:1) as solvent. These reaction conditions cause carbon–carbon bond cleavage of analogous acyclic β,β-diphenylethyl ethers to give products derived from the diphenylmethyl radical and the α-oxycarbocation intermediates. The purpose of this study was to determine if this reaction could be applied to five-membered cyclic derivatives to give 1,5-radical cations.The primary products from 8a and 8b were the dehydrogenated, aromatized 3-phenylbenzofurans 14a and 14b. These products react further; continued irradiation gave the methanol adducts, cis and trans-2-methoxy-3-phenyl-2,3-dihydrobenzofuran (15a and 15b, cis and trans). The only observed reaction of the indanes (9, cis and trans) was cis-trans isomerization. Deuterium was incorporated at the bis-benzylic position of 8 and 9 when the irradiation was carried out in acetonitrilemethanol-O-d. These results are consistent with reversible deprotonation from the radical cations. There was no evidence for carbon–carbon bond cleavage with either 8 or 9. The relative rate, deprotonation faster than carbon–carbon bond cleavage, is explained in terms of the conformation of the bond that cleaves in relation to the singly occupied molecular orbital (SOMO) of the radical cation. Oxidation potential measurements support the conclusion that the SOMO of 8 and 9 is largely associated with the fused phenyl ring and is therefore orthogonal to the benzylic carbon–carbon bond. Irradiation of cis or trans-2-methoxy-3-phenyl-2,3-dihydrobenzofuran (15a, cis or trans), under these conditions, leads to cis–trans isomerization. The mechanism in this case involves the reversible loss of methanol. There is evidence that the addition of methanol to 14 involves the sensitizer radical anion – 14 radical cation pair.In contrast with the fused bicyclic systems, the monocyclic tetrahydrofuran 10 and the methoxycyclopentane 11 both cleave under these conditions; the products are the expected acetals 22 and 29 formed from the intermediate 1,5-radical cations. In 10 and 11 the SOMO, which is largely associated with the diphenylmethyl moiety, can overlap with the adjacent carbon–carbon bond and cleavage occurs as in analogous acyclic systems. Both 10 and 11 are relatively stable to irradiation under conditions that are identical except with acetonitrile as solvent (without methanol). We found no evidence for cyclization of the intermediates (1,5-radical cation or 1,5-diradical) into the terminal phenyl ring.

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26

Feklicheva (Okul), Ekaterina M., Victor B. Rybakov, Evgeny V. Babaev, and Evgeny N. Ofitserov. "Synthesis and X-ray diffraction of derivatives 2,4-dimethyl-6-oxo-1,6-dihydropyridin-3-carboxamide." Butlerov Communications 60, no. 10 (October 31, 2019): 1–23. http://dx.doi.org/10.37952/roi-jbc-01/19-60-10-1.

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Based on the synthesized starting 2,4-dimethyl-6-oxo-1,6-dihydropyridin-3-carboxamide crystallizing as a dihydrate, 9 derivatives of it including O- and N-phenacyl substituted products were obtained through original rearrangements and cyclizations. The corresponding oxazolopyridinium perchlorate was obtained from the latter preparation in the presence of acid, from which indolysin was obtained under the action of a nitrogenous base. The obtained molecular and crystal structures of all the compounds were studied by single crystal diffraction: 2,4-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxamide dihydrate, 6-hydroxy-2,4-dimethyl-3-carbamoyl-pyridinium chloride monohydrate, 2,4-dimethyl-6-methoxypyridine-3-carboxamide, 1-[2-(4-methylphenyl)-2-oxoethyl]-2,4-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxamide, 2,4-dimethyl-6-oxo-1-[2- (4-[chlorophenyl)-2-oxoethyl]-1,6-dihydropyridine-3-carboxamide, 2,4-dimethyl-6-[2-(4-methylphenyl)-2-oxo-ethoxy]pyridin-3-carbox-amide, 2,4-dimethyl-6-[2-(4-chlorophenyl)-2-oxoethoxy] pyridin-3-carb xamide, 6-carbamoyl-2-(4-chlorophenyl)-5,7-dimethyl[1,3]oxazolo[3,2-a]pyridin-4 perchlorate, 7-methyl-5-morpholin-4 -yl-2-(4-chlorophenyl) indolysin-8-carboxamide. A structural analysis of the by-products of 1,4-bis (4-methylphenyl) butane-1,4-dione and 1,4-bis(4-chlorophenyl) butane-1,4-dione was also carried out. The synthesis methods of each of them are given. A comparative analysis of bond lengths, valence and torsion angles in similar fragments of molecules is carried out. Hydrogen bonds were revealed in the structures and their influence on the strength of molecular packing in crystals was shown. All structures of the studied compounds, in addition to XRD, are characterized by 1H NMR spectra.

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27

Wang, Bilin, Jing Shi, Yan Jun Hou, Wen Yi Chu, and Zhi Zhong Sun. "The crystal structure of tris(μ2-1,3-bis(4,4,4-Trifluoro-3-oxido-1-(oxo)but-2-en-1-yl)phenyl-/κ4O,O′:O′′,O′′′)-bis(1,2-dimethoxyethane-O,O′)-diterbium(III)." Zeitschrift für Kristallographie - New Crystal Structures 230, no. 4 (December 1, 2015): 371–73. http://dx.doi.org/10.1515/ncrs-2015-0035.

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AbstractC50H38F18O16Tb2, monoclinic, C2/c (No. 15), a = 15.6505(13) Å, b = 12.8157(10) Å, c = 29.4494(24) Å, α = 90.0(0)°, β = 91.9581(9)°, γ = 90.0(0)°, V = 91.9581(9) Å3, Z = 4, Rgt(F) = 0.0262, wRref(F2) = 0.0612, T = 293 K.

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28

Woo, Jeongkyu, Soo Kyung Kang, Ju Hee Han, Ki Ju Kim, Yu Ji Moon, Young Kwan Kim, and Seung Soo Yoon. "Red Phosphorescent Platinum(II) Complexes with Tetradentate Pyridine-Containing Ligands for Organic Light Emitting Diodes." Journal of Nanoscience and Nanotechnology 20, no. 11 (November 1, 2020): 6669–74. http://dx.doi.org/10.1166/jnn.2020.18758.

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Here, red phosphorescent platinum(II) complexes based on tetradentate pyridine-containing lig-ands are studied. To investigate their electroluminescent properties, multilayer devices were fabricated in the following sequence; ITO (180 nm)/4,4′,4″-Tris[2-naphthyl(phenyl)amino]triphenylamine (2-TNATA) (30 nm)/N, N′-di(1-naphthyl)-N,N′-diphenyl-1,1′-biphenyl)4,4′-diamine (NPB) (20 nm)/ Tris(4-carbazoyl-9-ylphenyl)amine (TCTA) (10 nm)/4,4′-Bis(N-carbazolyl)-1,1′-biphenyl (CBP) (20 nm)/Platinum(II) complex (20 nm)/1,3,5-Tris(1-Phenyl-1H-benzimidazol-2-yl)benzene) (TPBi) (40 nm)/Liq (2 nm)/Al (100 nm). In particularly, a device using platinum(II) complex based on N-(3,5-di-tert-butylphenyl)-3-(pyridin-2-yl)-N-(3-(pyridin-2-yl)phenyl)benzenamineligand showed the efficient red emission, with a luminous efficiency, power efficiency, and external quantum efficiency of, and the Commission International de LEclairge (CIE) coordinates of 27.26 cd/A, 10.54 lm/W, 8.50% at 20 mA/cm2, and (0.65, 0.33) at 11.0 V, respectively.

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29

Kang, Soo Kyung, Jeongkyu Woo, Ju Hee Han, Ki Ju Kim, Hakjun Lee, Young Kwan Kim, and Seung Soo Yoon. "Platinum (II) Complexes Based on Tetradentate Pyridine-Containing Ligands for Phosphorescent Organic Light-Emitting Diodes." Journal of Nanoscience and Nanotechnology 20, no. 11 (November 1, 2020): 6683–87. http://dx.doi.org/10.1166/jnn.2020.18774.

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In this study, we designed and synthesized two phosphorescent emitting materials based on tetradentate pyridine-containing ligands. Their photophysical properties were examined for OLEDs and multilayer devices using these materials were fabricated in the following sequence; ITO (180 nm)/4,4′,4″-Tris[2-naphthyl(phenyl)amino]triphenylamine (2-TNATA) (30 nm)/N,N′-di(1-naphthyl)-N,N′-diphenyl-1,1′-biphenyl)4,4′-diamine (NPB) (20 nm)/Tris(4-carbazoyl-9-ylphenyl)amine (TCTA) (10 nm)/4,4′-Bis(N-carbazolyl)-1,1′-biphenyl(CBP): 5, 8, 15% Platinum (II) complexes (20 nm)/1,3,5-Tris(1-Phenyl-1H-benzimidazol-2-yl)benzene) (TPBi) (40 nm)/Liq (2 nm)/Al (100 nm). In particularly, a device using Platinum (II) complex based on A/-(3,5-di-tert-butylphenyl)-6-phenyl-N-(6-phenylpyridin-2-yl)pyridin-2-amine ligand showed the efficient emission, with luminous efficiency, power efficiency, and external quantum efficiency, and the Commission International de LEclairge (CIE) coordinates of 29.29 cd/A, 9.37 lm/W, 8.66% at 20 mA/cm2, and (0.32, 0.62) at 8.0 V, respectively.

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30

Cho, Ching-Sheng, Wen-Bin Liau, and Leo-Wang Chen. "Single-crystal structure analysis of a novel aryl phosphinate diglycidyl ether." Acta Crystallographica Section B Structural Science 55, no. 4 (August 1, 1999): 525–29. http://dx.doi.org/10.1107/s010876819900018x.

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The crystal structure of 10-[2,5-bis(2,3-epoxy-1-propoxy)phenyl]-9-oxa-10-phosphaphenanthren-10-one has been studied by single-crystal X-ray diffraction. The unit cell of C24H21O6P, M r = 436.4, is triclinic, P1¯, with a = 8.507 (3), b = 10.613 (4), c = 12.457 (3) Å, α = 80.05 (3), β = 71.38 (2), γ = 76.69 (3)°, V = 1031.1 (6) Å3, Z = 2, D x = 1.406 Mg m−3 and μ(Mo Kα) = 0.17 mm−1. The final R (wR) is 0.063 (0.057) {w = 1/[σ2(F) + 0.0004F 2]} for 3619 unique reflections measured at 295 K. The aryl phosphinate group bonded to the central phenyl ring comes close to one of the two glycidyl ether groups, the epoxide ring of which is ordered. The epoxide ring far from the aryl phosphinate group is disordered. The NMR chemical shifts of the protons of the glycidyl ether group close to the aryl phosphinate group are reduced by the `ring-current effect'.

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31

Soman, Anjaly, and K. N. Narayanan Unni. "Enhancement in electron transport and exciton confinement in OLEDs: role of n-type doping and electron blocking layers." European Physical Journal Applied Physics 86, no. 1 (April 2019): 10201. http://dx.doi.org/10.1051/epjap/2019190020.

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Doped transport layers are essential for achieving high efficiency in organic light emitting diodes (OLEDs). We have studied the effect of doping the electron transport layer (ETL), tris-(8-hydroxyquinoline) aluminum (Alq3) with different percentages of lithium fluoride (LiF). We have also studied the effect of different electron blocking layers (EBLs) such as Tris (4-carbazoyl-9-ylphenyl)amine (TCTA), N,N'-Bis (naphthalen-1-yl)-N,N'-bis(phenyl)-benzidine(NPB), and Di-[4-(N,N-di-p-tolyl-amino)-phenyl]cyclohexane (TAPC) in an Alq3:2,3,6,7-Tetrahydro-1,1,7,7,-tetramethyl-1H, 5H, 11H −10-(2-benzothiazolyl)quinolizino[9,9a, 1gh] coumarin (C545T) based organic light emitting diode (OLED) with optimized ETL doping. TCTA was found to effectively block the electrons and influence the recombination region in the process. At a brightness of 1000 cd/m2, an improvement of 27.8% was observed in external quantum efficiency (EQE) for the device with TCTA as the EBL and doped Alq3 as the ETL, compared to the one with just NPB as both EBL and HTL.

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32

Beckmann, Jens, Jens Bolsinger, and Andrew Duthie. "The Reactivity of Diorganotellurium Oxides Towards Phenol and o-Nitrophenol. Hypervalent and Secondary Bonding of Four Different Product Classes." Australian Journal of Chemistry 61, no. 3 (2008): 172. http://dx.doi.org/10.1071/ch07329.

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The reaction of the diorganotellurium oxides R2TeO (R = Ph, p-MeOC6H4, p-Me2NC6H4) with phenol and o-nitrophenol produces diorganotellurium hydroxy phenolates, R2Te(OH)OPh (1, R = Ph; 2, R = p-MeOC6H4; 3, R = p-Me2NC6H4), diorganotellurium bis(phenolates) R2Te(OPh)2 (4, R = Ph; 5, R = p-MeOC6H4; 6, R = p-Me2NC6H4), tetraorganoditelluroxane bis(o-nitrophenolates), (R′O)R2TeOTeR2(OR′) (7, R = p-MeOC6H4; 8, R = p-Me2NC6H4; R′ = o-NO2C6H4), and a hexaphenyltritelluroxane bis(o-nitrophenolate) (R′O)Ph2TeOTePh2OTePh2(OR′) (9, R′ = o-NO2C6H4), respectively. The redistribution reactions of R2Te(OPh)2 (4, R = Ph; 5, R = p-MeOC6H4; 6, R = p-Me2NC6H4) with the corresponding diorganotellurium oxides R2TeO and diorganotellurium dichlorides R2TeCl2 (R = Ph, p-MeOC6H4, p-Me2NC6H4) give rise to the formation of moisture sensitive tetraorganoditelluroxane bis(phenolates) (PhO)R2TeOTeR2(OPh) (10, R = Ph; 11, R = p-MeOC6H4; 12, R = p-Me2NC6H4) and diorganotellurium chloro phenolates, R2Te(Cl)OPh (13, R = Ph; 14, R = p-MeOC6H4; 15, R = p-Me2NC6H4), respectively. The reaction of the diorganotellurium oxides R2TeO with the corresponding diorganotellurium dichlorides R2TeCl2 (R = Ph, p-MeOC6H4, p-Me2NC6H4) affords tetraorganoditelluroxane dichlorides ClR2TeOTeR2Cl (16, R = Ph; 17, R = p-MeOC6H4; 18, R = p-Me2NC6H4) as air-stable solid materials. The reactivity of 1–18 can be rationalized by the kinetic lability of the Te–O and Te–Cl bonds. Compounds 1–18 have been characterized by solution and solid-state 125Te NMR spectroscopy and 2, 4, 6, 7, 9, 17, and 18 have also been analyzed by X-ray crystallography.

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33

Amr, Abdel-Galil E. "Synthesis of Some New Linear and Chiral Macrocyclic Pyridine Carbazides as Analgesic and Anticonvulsant Agents." Zeitschrift für Naturforschung B 60, no. 9 (September 1, 2005): 990–98. http://dx.doi.org/10.1515/znb-2005-0914.

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A series of 2,6-disubstituted pyridine derivatives were prepared from 2,6-diacetylpyridine or 2,6- dicarbonyl pyridine dichloride as starting materials. Reaction of 2,6-diacetylpyridine 1 with hydroxylamine hydrochloride or different aromatic aldehydes afforded the corresponding 2,6-diacetylpyridine dioxime and 2,6-bis-[β -(2-thienyl)acryloyl]pyridine derivatives 2 and 3, respectively. Additionally, N2,N2‘-(pyridine-2,6-dicarbonyl)-L-amino acid hydrazides 5 were prepared starting from 2,6- dicarbonyl pyridine dichloride via the corresponding esters 4. Compound 3 was reacted with hydroxylamine hydrochloride to afford the 2,6-bis-[β -(2-thienyl)acryloyl-oxime]-pyridine derivative 6. Treatment of compounds 2 or 6 with phenyl isocyanate or phenyl isothiocyanate in refluxing dioxane gave the corresponding semicarbazide or thiosemicarbazide derivatives 7 and 8, respectively. Their treatment with toluene-3,5-diisocyanate afforded the macrocyclic semicarbzides 9 and 10, respectively. The chiral thiosemicarbazides 11a,b were however, prepared by treating compounds 5a,b with phenyl isothiocyanate followed by cyclization with sodium hydroxide (2N) yielding the triazoles 12a,b. Finally, the hydrazides 5a,b were treated with toluene-3,5-diisocyanate to afford the chiral macrocyclic tetrapeptide semicarbazides 13a,b in reasonable yields, while the expected cyclic dipeptide 14 was not formed. The structure assignments of the new compounds were based on chemical and spectroscopic evidence. The pharmacological screening showed that many of these compounds have good analgesic and anticonvulsant activities comparable to Voltarine® and Carbamazapine® used as reference drugs.

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34

Hintermaier, Frank, Sylvia Helding, Leonid B. Volodarsky, Karlheinz Sünkel, Kurt Polbom, and Wolfgang Beck. "Übergangsmetallkomplexe mit Nitroxidradikalen: Palladium-, Platin-, Pentamethylcyclopentadienyl-rhodium- und -iridium-Komplexe sowie α-Aminocarboxylatkomplexe mit Donor-haltigen Derivaten des 2,5-Dihydroimidazol-l-oxyls / Transition Metal Complexes of Nitroxide Radicals, Palladium, Platinum, Pentamethylcyclopentadienyl Rhodium and Iridium Complexes, and α-Aminocarboxylate Complexes with Derivatives of 2,5-Dihydroimidazole-l-oxyls." Zeitschrift für Naturforschung B 53, no. 1 (January 1, 1998): 101–9. http://dx.doi.org/10.1515/znb-1998-0118.

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2,5-Dihydroimidazoline-l-oxyl radicals I, II with imino substituents coordinate to Pd(II) and Pt(II) complexes with formation of the N,N chelate complexes 1-6. With oxygen containing substituents either monodentate N-coordination to give 8 or N ,O chelate formation to give 9 takes place, depending on the position of the oxygen atom relative to the ring nitrogen atom. With radicals III that also have the second ring nitrogen atom oxidized and the Rh(III) or Ir(III) complexes [Cp*MCl2]2 the O , O chelates 11 -13 could be obtained, while with Na2PdCl4 the heterocycle was destroyed with formation of a N,N chelate complex 10 of an α-nitrosooxime ligand. The orthopalladated 2,2,5,5 tetramethyl-4-phenyl-2,5-dihydroimidazoline-l-oxyl complex 7a reacts with several a-amino acidates under splitting of the dichloro bridge with formation of the C,N/N,O-bis-chelate complexes 7b-f. The molecular structures of 2 and 10 were determined by X-ray diffraction.

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35

Robertson, Katherine N., Pradip K. Bakshi, Susanne D. Lantos, T. Stanley Cameron, and Osvald Knop. "Crystal chemistry of tetraradial species. Part 9. The versatile BPh4- anion, or how organoammonium H(N) atoms compete for hydrogen bonding." Canadian Journal of Chemistry 76, no. 5 (May 1, 1998): 583–611. http://dx.doi.org/10.1139/v98-077.

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In organoammonium cations containing two or more N atoms, the H(N) atom introduced by the protonation may engage in an N→H(N)...Y bond to an external acceptor (anion or solvent molecule); in an intra-cation (intra-annular) N→H(N)...N' bond; or in a branched N→H(N)...N',Y bond(s), simultaneously intra-cation and to one or more external acceptors. The outcome of the competition for these bond types is determined by various factors, e.g., the size of the ring to be closed by insertion of the H(N) atom, steric accessibility of H(N), and the H-bond-forming strength of Y. Some of these are discussed in considerable detail and are exemplified by the hitherto unreported crystal structures of the tetraphenylborates (solvated or unsolvated) of the 2,2':6',2"-terpyridinium (1), 2,3-bis(2-pyridyl)pyrazinium (2), 2,2'-dipyridylammonium (3), 6,7-dihydro[b,j][1,10]phenanthrolinium (9), 2,4,7-triamino-6-pteridinium (triamterenium, 10), proton-sponge (1-Me2N-8-Me2NH-naphthalene, 11, 12), and 9-amino-1,2,3,4-tetrahydroacridinium (tacrinium, 13) cations. The crystal structures of the comparison compounds 2,3-bis(2-pyridyl)pyrazine (4) and its mono- (2A) and diprotonated (3) chlorides, and of 2-phenylpyridinium (6) and 7,8-benzoquinolinium (7, 8) tetraphenylborates, have also been determined. The many interesting features of these crystal structures, such as the X→H(X)...phenyl bonding (X = N, O, C), are commented upon and crystallographic comparisons with numerous literature compounds are offered. Included in the discussion are the monoprotonated intrabridgehead cations of the bicyclic diamines of Alder et al., the N-H(N)-N' angle of which has been shown, analytically, to be dominated by the size of the smallest of the rings in these tricyclic systems.Key words: crystal structures, hydrogen bonding, intrabridgehead cations, proton sponges, tetraphenylborates.

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36

Farkens, Michael, Thomas G. Meyer, Ion Neda, Ralf Sonnenburg, Christian Müller, Axel K. Fischer, Peter G. Jones, and Reinhard Schmutzler. "Zur Chemie der l,3,5-Triaza-2-phosphinan-4,6-dione. Teil VI. Darstellung von 1,3,5-Triaza-2 λ3-, 1,3,5-Triaza-2 λ4- und 1,3,5-Triaza-2 λ5-phosphinan-4,6-dionen / Chemistry of the 1,3,5-Triaza-2-phosphinane-4,6-diones. Part VI. Synthesis of 1,3,5-Triaza-2λ3-, 1,3,5-Triaza-2λ4- and 1,3,5-Triaza-2λ5-phosphinane-4,6-diones." Zeitschrift für Naturforschung B 49, no. 2 (February 1, 1994): 145–64. http://dx.doi.org/10.1515/znb-1994-0201.

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The reactions of 1,3,5-trimethylbiuret with dicyclohexylaminodichlorophosphine and with pyrrolidinodichlorophosphine furnished the triazaphosphinane-diones 1 and 2. Oxidation reactions of the 2-diorganoam ino-1,3,5-triorgano-1,3,5-triaza-2 λ3-phosphinane-4,6-diones 1, 2, and 4-9, as well as 2-fluoro-1,3,5-trimethyl-1,3,5-triaza-2λ3-phosphinane-4,6-dione 10 with hydrogen peroxide, elemental sulphur, phenyl azide, 1-adamantyl azide,p-nitrobenzoyl azide, tetrachloro-orthobenzoquinone, tetrabromo-orthobenzoquinone, 3,5-di-t-butyl-orthobenzoquinone, and hexafluoroacetone led to the respective oxidation products, 12-32, involving either λ4P or λ5P. In the reaction o f the P(III)C1 derivative 11 with 3-m ethyl-l,5-diphenyl-l,5- bis(trimethylsilyl)biuret the bifunctional compound 33 was produced. The new com pounds 1,2 and 12-33 were characterized via their 1H, 13C and 31P and, where appropriate, 19F NMR spectra. In the case o f the four compounds, 3 (previously described in the literature [2]), 13, 31, and 33, single crystal X-ray diffraction studies were conducted. Unusually for this type of heterocycle 3 displays a 1,4-diplanar ring conformation because o f the bulky aromatic substituents. 13 shows an envelope conformation. The hydrogen peroxide solvent molecule has crystallographic inversion symmetry, but may be disordered. In 31 the coordination geometry at phosphorus is trigonal bipyramidal. The five-membered ring shows a twist conform ation associated with the bulky trifluoromethyl groups. The exocyclic P-N bonds in 33 are unusually long.

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37

Klein, Hans-Friedrich, Xiaoyan Li, Ulrich Flörke, and Hans-Jürgen Haupt. "Hydrido(acylenolato)cobalt(III)-Verbindungen mit Trimethylphosphan- Liganden: Insertionsreaktionen mit Alkinen und die ersten Carbonylcobalt(III)-Komplexe / Hydrido(acylenolato)cobalt(III) Compounds Containing Trimethylphosphane Ligands: Insertion Reactions with Alkynes and the First Carbonylcobalt(III) Complexes." Zeitschrift für Naturforschung B 55, no. 8 (August 1, 2000): 707–17. http://dx.doi.org/10.1515/znb-2000-0807.

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Abstract Formal insertion of phenylethyne into Co-H functions of mer-octahedral acyl(enolato)-cobalt(III) hydrides 1-3 proceeds under ambient conditions affording η1-vinylcobalt(III) compounds where the dianionic acyl(enolato) ligands are derived from 2-formyl-4-phenyl-cyclohexanone (4), 1-formyl-cyclohexan-2-one (5), and 3-hydroxo-2,3-diphenyl-propenal (6). Dissociation and association of trimethylphosphane results in a reversible transformation of penta-coordinate complexes 4 -6 into hexa-coordinate ones 7 -9, respectively, involving different tautomeric vinyl species. In toluene solution 9 rearranges by reductive C,C coupling into a 5,6-η2-olefin(enolato)cobalt(I) complex 10. Trimethylsilylethyne undergoes a hydrolytic desilylation reaction which is followed by reductive C,C-coupling reactions of acyl and vinyl functions selectively producing chelating η1-enolato-5,6-η2-olefin ligands in cobalt(I) com pounds 13 -16 where the (ax,eq)chelating ligands are derived from 1-formyl-cyclohexan-2-one (13), 3-hydroxo-2,3-diphenyl-propenal (14), 2-formyl-α-tetralone (15), and 2-formyl-4-tert-butyl-cyclohexanone (16). An axial position of the enolato-O donor in the trigonal bipyramidal configuration of complex 15 has been confirmed by X-ray diffraction analysis. With 1,4-bis(trimethylsilyl)buta-diyne 1,2-addition in cobalt(III) hydrides 2, 3, 11 (as deriverd from 2-formyl-α-tetralone), and 12 (as derived from 2-formyl-4-tert-butyl-cyclohexanone) produces 2-metalated vinyl groups in compounds 17 -20. Dissociation of trimethylphosphane from 17 and 19 does not activate C,C coupling at the cobalt(III) centre of penta-coordinate 21 and 22. Steric congestion in compounds 17, 18, and 20 favours exchange of trimethylphosphine for carbon monoxide affording the first octahedral carbonyl complexes of cobalt (d6) (23 -25). In the crystal and in solution a meridional configuration is adopted by complex 23 with the CO group in a position opposite to the acyl function.

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38

Loh, Claas, Carsten Glock, Steffen Ziemann, Helmar Görls, Sven Krieck, and Matthias Westerhausen. "Synthesis and Characterization of Strontium Bis(N-isopropylanilide) and Comparison with the Lighter Magnesium and Calcium Congeners." Zeitschrift für Naturforschung B 68, no. 5-6 (June 1, 2013): 518–32. http://dx.doi.org/10.5560/znb.2013-3044.

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The metathesis reaction of strontium diiodide [(thf)5SrI2] with K[N(Ph)iPr] in THF yields [(thf)4Sr{N(Ph)iPr}2] (1). Ligand exchange reactions with 1,2-dimethoxyethane (DME), tetramethylethylenediamine (TMEDA), and pentamethyldiethylenetriamine (PMDETA) allow the isolation of the corresponding adducts [(dme)2Sr{N(Ph)iPr}2] (2), [(tmeda)(thf)Sr{N(Ph)iPr}2] (3) and [(pmdeta)Sr{N(Ph)iPr}2] (4), respectively. Magnesiation of N-isopropylaniline with dibutylmagnesium in THF leads to the formation of [(thf)2Mg{N(Ph)iPr}2] (5). A similar reaction in TMEDA gives nearly insoluble crystalline [(tmeda)Mg{N(Ph)iPr}2] (7), whereas the mother liquor contains heteroleptic [(tmeda)(nBu)Mg{N(Ph)iPr}] (6). Magnesiation of N-isopropylaniline in 2,2,5,5-tetramethyltetrahydrofuran (Me4thf) yields [(Me4thf)Mg{N(Ph)iPr}2] (8) with a threecoordinate metal center. In hydrocarbons this complex loses the bulky ether base, and the solvent-free dimer [Mg{N(Ph)iPr}2]2 (9) can be isolated. Reaction of this complex with 1,2- dimethoxyethane or metalation of N-isopropylaniline with dibutylmagnesium in DME yield the dme adduct, [(dme)Mg{N(Ph)iPr}2] (10). The crystal structures show that the nitrogen atoms of the magnesium-bound N-isopropylanilide ions are in planar environments whereas strontium-bound N-isopropylanilide ions show rather short contacts between the alkaline earth metal and the ipsocarbon atoms of the phenyl groups leading to a pyramidalization of the coordination of the nitrogen atoms

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39

Koradecka, Danuta, and Jolanta Skowroń. "The activity of the Interdepartmental Commission for Maximum Admissible Concentrations and Intensities for Agents Harmful to Health in the Working Environment in 2017 and the work plan in 2018." Podstawy i Metody Oceny Środowiska Pracy 34, no. 1(95) (March 27, 2018): 111–29. http://dx.doi.org/10.5604/01.3001.0011.5835.

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In 2017, the Commission met at three sessions, in which 16 documentations for recommended exposure limits of chemical substances were discussed. Moreover, the Commission discussed: − the positions of the Interdepartmental Commission for MAC and MAI regarding: smog, limit value of nitric oxide in the underground mining and tunnels sector and binding value for 1,2-dichloroethane − introduction of the "skin" notation (substances absorption through the skin may be important as in the case of inhalation) for chemical substances included in the regulation of the Minister of Labour and Social Policy of 6 June 2014. The Commission suggested to the Minister of Family, Labour and Social Policy the following changes in the list of MAC values: − adding five new chemical substances to the list of MAC values: qinoline (CAS: 91-22-5, Carc. 1B, skin), cisplatin (CAS: 15663-27-1, Carc. 1B, skin), N-hydroxyurea (CAS: 127-07-1, Carc. 1B), potassium bromate (CAS: 7758-01-2, Carc. 1B, skin) oraz 3,3’-dimethylbenzidene (CAS: 119-903-7) and salts: 3,3’ dimethylbenzidene dihydrochloride (CAS: 612-82-2, Carc. 1B) − changing MAC values for 10 chemicals: bis-phenol A (CAS: 80-05-7), acrylic acid (CAS: 79-10-7, skin), nitrogen oxide (CAS: 10102-43-9 ), dichloromethane (CAS: 75-09-2, skin), 1,1-dichloroethylene (CAS: 75-35-4), hydrogenated terphenyls (CAS: 61788-32-7), 2-nitropropane (CAS: 79-46-9, skin), 1,2-epoxypropane (CAS: 75-56-9), 1,2-dichloroethane (CAS: 107-06-2, skin), phenylhydrazine (CAS: 100-63-0, skin) as phenylhydrazine) and its salts: phenylhydrazine hydrochloride (CAS: 59-88-1; 27140-08-5, skin), phenylhydrazine sulphate (CAS: 52033-74-6, skin) − adding to Annex 1 the "skin" notation (substances absorption through the skin may be important as in the case of inhalation) for chemical substances included in the regulation of the Minister of Labour and Social Policy (Journal of Laws of 2014, item 817 with amended). The Interdepartmental Commission for MAC and MAI adopted the MAC value for inhalable fraction of urea at the level of 10 mg/m3 as the value recommended for manufacturers and plants. The documentation of the proposed occupational exposure limit values for urea with the recommended value of 10 mg/m3 and with the method of determining it concentrations in the working environment will be published in "Principles and Methods of Assessing the Working Environment". Four issues of the "Principles and Methods of Assessing the Working Environment " were published in 2017. The following were published: 12 documentation of occupational exposure limit, 12 methods of determining chemical concentrations in the working environment, two articles, a procedure for measuring electromagnetic field, a report on the activities of the Interdepartmental Commission for MACs and MAIs in 2017 and indexes of documentations, methods and articles published between 2000–2017. Three sessions of the Commission are planned for 2018. MAC values for 15 chemicals substances will be discussed at those meetings. The Commission and the Group of Experts will continue working on adapting the Polish list of maximum admissible concentrations to proposals for binding values for carcinogenic or mutagenic substances, proposed concentration limit values developed by the Committee for Risk Assessment (RAC) and on work being done at SCOEL.

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40

Ibraheam, Israa Adnan, Imad Hadi Hameed S., and Haider Mashkoor Hussein. "Cyclamen persicum: Methanolic Extract Using Gas Chromatography-Mass Spectrometry (GC-MS) Technique." International Journal of Pharmaceutical Quality Assurance 8, no. 04 (December 25, 2017). http://dx.doi.org/10.25258/ijpqa.v8i04.10546.

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Cyclamen was traditionally classified in the family Primulaceae, was reclassified in the subfamily Myrsinoideae within the family Primulaceae. The objective of this study was analysis of the secondary metabolite products. Bioactives are chemical compounds often referred to as secondary metabolites. Thirty eight bioactive compounds were identified in the methanolic extract of Cyclamen persicum. The identification of bioactive chemical compounds is based on the peak area, retention time molecular weight and molecular formula. GC-MS analysis of Cyclamen persicum revealed the existence of the3-Oxo-androsta-1,4-dien-17β-spiro-2'-3'-oxo-oxetane, 3,5-Dithiahexanol 5,5-dioxide, 1-(2-Nitrophenyl)piperazine, Oxime-,methoxy-phenyl- , Cyclohexene, 1-methyl-4-(1-methylethenyl)-,(S)-, D-Limonene , Fumaric acid,3-methylbut-3-enyl undecyl ester, Geranyl vinyl ether, 3,6,9,12-Tetraoxatetradecan -1-ol,14-[4-(1-,1,3,3-tetramethylbu, Cis-5,8,11,14,17-Eicosapentaenoic acid, α-Terpineol, 3-Allyl-6-methoxyphenol, 3-Cyclohexene-1-methanol,α,α,4-trimethyl-,acetate, Orcinol, 4,5-di-epi-aristolochene, Trans-calamenene, 3-(N,N-Dimethyllaurylammonio)propanesulfonate, Deoxyqinghaosu, Atranorin , N-[4-(4-Chlorophenyl)isothiazol-5-yl)-1-methylpiperidin-2-imine, 10-Heptadecen-8-ynoic acid , methyl ester, (E)-, 2-Pentadecanone,6,10,14-trimethyl-, Caffeine, 4,4,8-Trimethyltricyclo[6.3.1.0(1.5)]dodecane-2,9-diol , Bufa-20,22-dienolide, 3,14-dihydroxy-,(3β,5β)-, 1-(3-methyl-2-butenyl)-3,6-diazahomoadamantan-9-ol , 9,12-Octadecadienoic acid (Z,Z)-, methyl ester, 9-Octadecenamide,(Z)-, 9,10-Secocholesta -5,7,10(19)-triene-3,24,25-triol,(3β,5Z,7E)-, Tributyl acetylcitrate, Cyproheptadine, 3,9-Epoxypregn-16-en-20-one , 3-methoxy-7,11,18-triacetoxy- , 17-Pentatriacontene, Phthalic acid , bis(7-methyloctyl) ester, Phthalic acid, di(6-ethyl-3-octyl) ester, Ergosterol, γ-Sitosterol and Friedelan-3-one.

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41

Percino, M., Maria Castro, Margarita Ceron, Guillermo Soriano-Moro, Victor Chapela, and Francisco Melendez. "X-ray molecular structure and theoretical study of 1,4-bis[2-cyano-2-(o-pyridyl)ethenyl]benzene." Chemical Papers 68, no. 2 (January 1, 2014). http://dx.doi.org/10.2478/s11696-013-0434-5.

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AbstractThe structural characterisation of the molecule 1,4-bis[2-cyano-2-(o-pyridyl)ethenyl] benzene obtained through Knoevenagel condensation is reported. The single crystals, as light brown rods, were cultured from a chloroform solution using a slow evaporation method at ambient temperature. The compound crystallised in the monoclinic system belonging to the C2/c space group with a = 26.4556(9) Å, b = 3.73562(10) Å, c = 18.4230(6) Å, β = 109.841(4)° and the asymmetric unit comprising Z = 4. The structure is ordered and the molecules of the title compound exhibited a lattice with water molecules located at sites of inversion and two-fold axial symmetries. Thus, only halves of the molecules are symmetrically independent. The lattice is reported and contrasted with X-ray single-crystal diffraction and theoretical calculations of 1,4-bis(1-cyano-2-phenylethenyl)benzene. By using density functional theory (DFT) and second order Moller-Plesset (MP2) theoretical calculations, the ground state geometry in the whole molecule at the B3LYP/6-31+G(d,p), and MP2/6-31+G(d,p) theory levels, respectively, were optimised. The DFT calculations showed a quasi-planar structure of the molecule, whereas the wave function-based MP2 method afforded a non-planar optimised structure with significant torsion angles between the pyridine and phenyl rings.

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Journal articles on the topic 'Phenanthroline-1,10(bis-(methyl-4 phenyl)-2,9)'

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