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Relevant bibliographies by topics / Phenothiazine drug structure

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Academic literature on the topic 'Phenothiazine drug structure'

Author: Grafiati

Published: 4 June 2021

Last updated: 15 February 2022

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Journal articles on the topic "Phenothiazine drug structure"

1

Poła, Andrzej, Anna Palko-Łabuz, and Kamila Środa-Pomianek. "Theoretical Study of 2-(Trifluoromethyl)phenothiazine Derivatives with Two Hydroxyl Groups in the Side Chain-DFT and QTAIM Computations." Molecules 26, no. 17 (August 29, 2021): 5242. http://dx.doi.org/10.3390/molecules26175242.

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Phenothiazines are known as synthetic antipsychotic drugs that exhibit a wide range of biological effects. Their properties result from the structure and variability of substituents in the heterocyclic system. It is known that different quantum chemical properties have a significant impact on drug behavior in the biological systems. Thus, due to the diversity in the chemical structure of phenothiazines as well as other drugs containing heterocyclic systems, quantum chemical calculations provide valuable methods in predicting their activity. In our study, DFT computations were applied to show some thermochemical parameters (bond dissociation enthalpy—BDE, ionization potential—IP, proton dissociation enthalpy—PDE, proton affinity—PA, and electrontransfer enthalpy—ETE) describing the process of releasing the hydrogen/proton from the hydroxyl group in the side chain of four 2-(trifluoromethyl)phenothiazine (TFMP) derivatives and fluphenazine (FLU). Additional theoretical analysis was carried out based on QTAIM theory. The results allowed theoretical determination of the ability of compounds to scavenge free radicals. In addition, the intramolecular hydrogen bond (H-bond) between the H-atom of the hydroxyl group and the N-atom located in the side chain of the investigated compounds has been identified and characterized.

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2

Berdyaev, S. Yu, A. I. Turilova, Z. P. Senova, A. N. Gritsenko, N. V. Kaverina, and A. P. Skoldinov. "Acyl derivatives of phenothiazine and their dibenzazepine analogs: Structure and antiarrhythmic activity." Pharmaceutical Chemistry Journal 25, no. 1 (January 1991): 1–4. http://dx.doi.org/10.1007/bf00766356.

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3

Mir, Shafia, Ayaz Mahmood Dar, and Bashir Ahmad Dar. "Synthetic Strategies of Benzothiazines: A Mini Review." Mini-Reviews in Organic Chemistry 17, no. 2 (February 28, 2020): 148–57. http://dx.doi.org/10.2174/1570193x16666181206101439.

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Benzothiazine is a heterocyclic compound consisting of a benzene ring attached to the 6- membered thiazine ring. The benzothiazines constitute the group of heterocyclic compounds as they have found a variety of industrial uses and show promise as herbicides. Besides this, benzothiazines play an important role in the field of drug discovery as they have the potential to act as drug candidates for the treatment of a large number of diseases including, cancer, vasorelaxant, diabetic, hypertension, mycotic infection and microbial infection. The presence of nitrogen-sulphur axis and similarity in the structure with phenothiazine drugs help the benzothiazines to act as drugs for the treatment of a number of diseases. Herein, we represent different synthetic strategies for the simple and multi-component synthesis of benzothiazine heterocyclic derivatives. The strategies mostly involve the use of 2-aminothiophenol, 1, 3-dicarbonyl compounds or α-haloketones. In almost all the strategies, the potential yields have been obtained.

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4

Pluta, Krystian, Małgorzata Jeleń, Beata Morak-Młodawska, Michał Zimecki, Jolanta Artym, Maja Kocięba, and Ewa Zaczyńska. "Azaphenothiazines – promising phenothiazine derivatives. An insight into nomenclature, synthesis, structure elucidation and biological properties." European Journal of Medicinal Chemistry 138 (September 2017): 774–806. http://dx.doi.org/10.1016/j.ejmech.2017.07.009.

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5

Shekhar, H., and Manoj Kumar. "Studies on phase diagram, thermodynamic stability and interfacial structure of solid dispersions of phenothiazine-adipic acid drug system." Molecular Crystals and Liquid Crystals 689, no. 1 (August 13, 2019): 60–71. http://dx.doi.org/10.1080/15421406.2019.1669294.

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6

Murray, Michael. "Inhibition of hepatic drug metabolism by phenothiazine tranquilizers: quantitative structure-activity relationships and selective inhibition of cytochrome P-450 isoform-specific activities." Chemical Research in Toxicology 2, no. 4 (July 1989): 240–46. http://dx.doi.org/10.1021/tx00010a005.

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7

Zarafiants, G. N., V. D. Isakov, and T. V. Gorbacheva. "QUESTIONS OF DYNAMICS, FORENSIC MEDICAL AND FORENSIC CHEMICAL DIAGNOSTICS OF METHADONE POISONING IN SAINT PETERSBURG IN 2009-2018." Toxicological Review, no. 1 (February 24, 2020): 2–7. http://dx.doi.org/10.36946/0869-7922-2020-1-2-7.

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Acute poisonings occupy one of the leading places in the structure of mortality due to external causes in the Russian Federation. In Saint Petersburg, there are consistently high rates of drug poisonings (especially methadone poisoning). Reports, statistical maps and other information of the Bureau of Forensic Medical Expertise for the period 2009 – 2018 were used for this study. The research methods were a selective copy of the data, including the results of a forensic chemical study, the calculation of statistical coefficients, descriptive. The analysis showed a decrease in mortality due to external causes in Saint Petersburg in 2009-2018, indicators (per 100 thousand of the population of Saint Petersburg) decreased gradually from 99,3 to 69,8. Acute poisoning of chemical etiology was in the 2nd place (24,9%) after mechanical injury. In the structure of acute poisoning of chemical etiology, the 1st place was occupied by fatal drug poisoning (45,1%). Their share was 28,7% in 2009-2011. It increased sharply up to 52,2% in the period 2012-2018 and began to change both qualitative and quantitative. In Saint Petersburg there were 19 fatal cases of methadone poisoning (0,04 per 100 thousand people) in 2009 and 599 cases (11,19 per 100 thousand people) in 2018. The number of forensic studies on the identification of methadone sharply increased (9 times). In almost half of the poisoning’s cases ethanol, other narcotic drugs (amphetamine derivatives, morphine, cocaine, etc.), as well as drugs and psychotropic substances (derivatives of barbituric acid, benzodiazepine, phenothiazine, etc.) were revealed along with methadone.Forensic medical diagnostics of methadone poisoning are based on the results of chromatography-mass spectrometry, morphological features (macro- and microscopic), analysis of the clinical picture (from medical documents), and consideration of the circumstances of the poisoning. The combined reception of methadone, ethanol and other narcotic and / or psychotropic drugs has a potentiating deprimative effect, aggravates the clinical and morphological picture of poisoning, which must be taken into account when diagnosing them.

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8

Mao, Meng-Xi, Fang-Ling Li, Yan Shen, Qi-Ming Liu, Shuai Xing, Xu-Feng Luo, Zhen-Long Tu, Xue-Jun Wu, and You-Xuan Zheng. "Simple Synthesis of Red Iridium(III) Complexes with Sulfur-Contained Four-Membered Ancillary Ligands for OLEDs." Molecules 26, no. 9 (April 29, 2021): 2599. http://dx.doi.org/10.3390/molecules26092599.

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Phosphorescent iridium(III) complexes have been widely researched for the fabrication of efficient organic light-emitting diodes (OLEDs). In this work, three red Ir(III) complexes named Ir-1, Ir-2, and Ir-3, with Ir-S-C-S four-membered framework rings, were synthesized efficiently at room temperature within 5 min using sulfur-containing ancillary ligands with electron-donating groups of 9,10-dihydro-9,9-dimethylacridine, phenoxazine, and phenothiazine, respectively. Due to the same main ligand of 4-(4-(trifluoromethyl)phenyl)quinazoline, all Ir(III) complexes showed similar photoluminescence emissions at 622, 619, and 622 nm with phosphorescence quantum yields of 35.4%, 50.4%, and 52.8%, respectively. OLEDs employing these complexes as emitters with the structure of ITO (indium tin oxide)/HAT-CN (dipyra-zino[2,3-f,2′,3′-h]quinoxaline-2,3,6,7,10,11-hexacarbonitrile, 5 nm)/TAPC (4,4′-cyclohexylidenebis[N,N-bis-(4-methylphenyl)aniline], 40 nm)/TCTA (4,4″,4″-tris(carbazol-9-yl)triphenylamine, 10 nm)/Ir(III) complex (10 wt%): 2,6DCzPPy (2,6-bis-(3-(carbazol-9-yl)phenyl)pyridine, 10 nm)/TmPyPB (1,3,5-tri(mpyrid-3-yl-phenyl)benzene, 50 nm)/LiF (1 nm)/Al (100 nm) achieved good performance. In particular, the device based on complex Ir-3 with the phenothiazine unit showed the best performance with a maximum brightness of 22,480 cd m−2, a maximum current efficiency of 23.71 cd A−1, and a maximum external quantum efficiency of 18.1%. The research results suggest the Ir(III) complexes with a four-membered ring Ir-S-C-S backbone provide ideas for the rapid preparation of Ir(III) complexes for OLEDs.

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9

Xia, Lin-Ying, Ya-Liang Zhang, Rong Yang, Zhong-Chang Wang, Ya-Dong Lu, Bao-Zhong Wang, and Hai-Liang Zhu. "Tubulin Inhibitors Binding to Colchicine-Site: A Review from 2015 to 2019." Current Medicinal Chemistry 27, no. 40 (November 26, 2020): 6787–814. http://dx.doi.org/10.2174/0929867326666191003154051.

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Due to the three domains of the colchicine-site which is conducive to the combination with small molecule compounds, colchicine-site on the tubulin has become a common target for antitumor drug development, and accordingly, a large number of tubulin inhibitors binding to the colchicine-site have been reported and evaluated over the past years. In this study, tubulin inhibitors targeting the colchicine-site and their application as antitumor agents were reviewed based on the literature from 2015 to 2019. Tubulin inhibitors were classified into ten categories according to the structural features, including colchicine derivatives, CA-4 analogs, chalcone analogs, coumarin analogs, indole hybrids, quinoline and quinazoline analogs, lignan and podophyllotoxin derivatives, phenothiazine analogs, N-heterocycle hybrids and others. Most of them displayed potent antitumor activity, including antiproliferative effects against Multi-Drug-Resistant (MDR) cell lines and antivascular properties, both in vitro and in vivo. In this review, the design, synthesis and the analysis of the structure-activity relationship of tubulin inhibitors targeting the colchicine-site were described in detail. In addition, multi-target inhibitors, anti-MDR compounds, and inhibitors bearing antitumor activity in vivo are further listed in tables to present a clear picture of potent tubulin inhibitors, which could be beneficial for medicinal chemistry researchers.

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10

Yang, Wei, Xiaolong Liu, Chunli Song, Sen Ji, Jianhong Yang, Yang Liu, Jing You, et al. "Structure-activity relationship studies of phenothiazine derivatives as a new class of ferroptosis inhibitors together with the therapeutic effect in an ischemic stroke model." European Journal of Medicinal Chemistry 209 (January 2021): 112842. http://dx.doi.org/10.1016/j.ejmech.2020.112842.

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Dissertations / Theses on the topic "Phenothiazine drug structure"

1

Jones, T. "Structure disposition relationships amongst phenothiazine drugs." Thesis, Cardiff University, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.379191.

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Book chapters on the topic "Phenothiazine drug structure"

1

Attwood, D., E. Boitard, J. P. Dubès, H. Tachoire, V. Mosquera, and V. Perez Villar. "Association Models for Phenothiazine Drugs in Aqueous Solution." In The Structure, Dynamics and Equilibrium Properties of Colloidal Systems, 103–29. Dordrecht: Springer Netherlands, 1990. http://dx.doi.org/10.1007/978-94-011-3746-1_8.

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