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Relevant bibliographies by topics / Phenothiazines

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Academic literature on the topic 'Phenothiazines'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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Journal articles on the topic "Phenothiazines"

1

K ymet Berkil Akar, K. ymet Berkil Akar, and O. uzhan Bebek and Bar Eran O uzhan Bebek and Bar Eran. "Synthesis and Characterization of 1,4-Dibromo-5H-benzo[a]phenothiazin-5-one and 8,13-Dibromo-7H-naphtho[2,3-a]phenothiazin-7-one for Use as Novel Fingermark Visualisation Reagents." Journal of the chemical society of pakistan 46, no. 3 (2024): 322. http://dx.doi.org/10.52568/001464/jcsp/46.03.2024.

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In the presented study, novel compounds bearing the benzo[a]phenothiazine or naphtho[a]phenothiazin skeletons were developed for the first time as fingermark detecting reagents on paper surfaces which were then investigated in detail. First, two phenothiazine derivatives, 1,4-dibromo-5H-benzo[a]phenothiazin-5-one and 8,13-dibromo-7H-naphtho[2,3-a]phenothiazin-7-one were synthesized and characterized by spectroscopic methods. The phenothiazines were tested as potential reagents for latent fingermarks on copier paper and were then compared with 1,8-diazofluoren-9-one (DFO). Both compounds reacte

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2

Durst, R., P. Rosca-Rebaudengo, and D. Admon. "Phenothiazine-Associated Supraventricular Tachycardia." Australian & New Zealand Journal of Psychiatry 28, no. 2 (1994): 333–36. http://dx.doi.org/10.1080/00048679409075649.

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Psychotropic medications, mainly phenothiazines, are known to be associated with cardiac insult. The case report presented here describes nearly fatal arrhythmia (sustained supraventricular tachycardia) consequent to phenothiazine treatment. The authors aim to alert psychiatrists to the possible adverse, and even fatal, effects of phenothiazines.

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Dixit, Yogesh, Rahul Dixit, Naveen Gautam, and D. C. Gautam. "Synthesis of Bioactive Fluorinated 10H-Phenothiazines and their Sulfone Derivatives." E-Journal of Chemistry 5, s1 (2008): 1063–68. http://dx.doi.org/10.1155/2008/809419.

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The present communication deals with the synthesis of a series of fluorinated 10H-phenothiazines. 10H-phenothiazines is prepared by Smiles rearrangement of substituted 2-foramido-2´-nitrodiphenylsulfide. Substituted 2-foramido-2´-nitrodiphenylsulfide were obtained by the reaction of 2-amino-3-fluorobenzenethiol witho-halonitrobenzenes followed by formylation and 1-nitro/1-halo-10H-phenothiazines have been prepared by the reaction of substituted 2-aminobenzenethiols with reactiveo-halonitrobenzene containing a nitro group or halogen atom ato-position to the reactive halogen atom directly yielde

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4

Chan, Ying Ying, Yong Mei Ong, and Kim Lee Chua. "Synergistic Interaction between Phenothiazines and Antimicrobial Agents against Burkholderia pseudomallei." Antimicrobial Agents and Chemotherapy 51, no. 2 (2006): 623–30. http://dx.doi.org/10.1128/aac.01033-06.

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ABSTRACT The gram-negative soil bacillus Burkholderia pseudomallei is the causative agent of melioidosis, a severe and potentially fatal septicemic disease that is endemic to Southeast Asia and northern Australia. Its intrinsic resistance to many antibiotics is attributed mainly to the presence of several drug efflux pumps, and therefore, inhibitors of such pumps are expected to restore the activities of many clinically important antimicrobial agents that are the substrates of these pumps. The phenothiazine antipsychotic and antihistaminic drugs prochlorperazine, chlorpromazine, and promazine

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5

Young, Allan, and Robert Kehoe. "Two Cases of Agranulocytosis on Addition of a Butyrophenone to a Long-Standing Course of Phenothiazine Treatment." British Journal of Psychiatry 154, no. 5 (1989): 710–12. http://dx.doi.org/10.1192/bjp.154.5.710.

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Two cases of agranulocytosis occurring after addition of a butyrophenone to a course of phenothiazine treatment are reported and possible mechanisms for this interaction are discussed. Agranulocytosis is a well-documented adverse effect of phenothiazine administration (Vincent, 1986). Important factors are the total amount of drug given and the duration of administration. Agranulocytosis usually occurs within the first three months of therapy (Pisciotta, 1971; Marcus & Mulvihill, 1978) and the relationship with the cumulative dose has been emphasised (Ananth et al, 1973). Agranulocytosis f

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6

Khadieva, Alena I., Vladimir V. Gorbachuk, and Ivan I. Stoikov. "Oligomerization of phenothiazin-5-ium tetraiodide in the presence of bases." Butlerov Communications 62, no. 6 (2020): 34–39. http://dx.doi.org/10.37952/roi-jbc-01/20-62-6-34.

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Methylene blue and its structural analogs (phenothiazine derivatives) are well known photodynamically and photochemically active agents, which are used in modern medicine, biology, and industry due to their low toxicity, high absorption in the therapeutic window region (600-660 nm). Methylene blue being one of the most studied phenothiazine derivative is employed as an antibacterial agent and also as an antidote to cyanide, carbon monoxide and hydrogen sulfide. Phenothiazin-5-ium tetraiodide is one of the most convenient precursors for the synthesis of structural analogues of methylene blue am

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7

SANDYK, R. "Phenothiazine-Induced Sleep Apneas and the Opioid System." Pediatrics 77, no. 2 (1986): 261–62. http://dx.doi.org/10.1542/peds.77.2.261a.

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To the Editor.— I was interested in the report by Kahn et al.1 demonstrating an increase in the number of central apneas following phenothiazine administration to infants. Administration of phenothiazines to infants less than 1 year of age could precipitate sudden death in apnea-prone subjects. Although the authors suggested several possible mechanisms linking the effects of phenothiazines with sudden infant death syndrome (SIDS), an apparent role of the opioid system has not been mentioned. The endogenous opioid system has been implicated in the central control of respiration.2

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8

Xia, Wang, Zi-An Zhou, Jie Lv, Shao-Hua Xiang, Yong-Bin Wang, and Bin Tan. "Facile synthesis of N-aryl phenothiazines and phenoxazines via Brønsted acid catalyzed C–H amination of arenes." Chemical Communications 58, no. 10 (2022): 1613–16. http://dx.doi.org/10.1039/d1cc06730c.

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An organocatalytic C–H amination of azonaphthalenes with phenothiazines and phenoxazines has been established. N-naphthyl phenothiazine and phenoxazine structures which are of significance in various fields could now be accessed in high efficiency.

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Wu, San, Wei-Ye Hu, and Song-Lin Zhang. "Potassium carbonate-mediated tandem C–S and C–N coupling reaction for the synthesis of phenothiazines under transition-metal-free and ligand-free conditions." RSC Advances 6, no. 29 (2016): 24257–60. http://dx.doi.org/10.1039/c6ra01295g.

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A potassium carbonate-mediated tandem coupling reaction for the synthesis of phenothiazines is described. This protocol affords an efficient approach for the construction of phenothiazine derivatives without the need for addition of transition-metal catalyst or ligand.

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(Miss), A. M. DAVE, N. BHATT K., K. UNDAVIA N., and B. TRIVEDl P. "Studies on Synthesis of Haloginated Phenothiazine Derivatives." Journal of Chemical Indian Society Vol. 65, May 1988 (1988): 365–66. https://doi.org/10.5281/zenodo.6279483.

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University Department of Chemistry, Bhavnagar University Bhavnagar-.364-002 <em>Manuscript received 12 October 1987, revised 4 February 1988, accepted 21 March 1988</em> 1,3,7,9-Tetrachloro-10-(substituted-benzthiazol-2<em>'</em>-ylaminoacetyl)phenothiazines have been synthesised by condensation of the chloroacetyl derivative of phenothiazine with substituted-2-aminobenzthiazoles. The haloginated derivatives of phenothiazine were screened for their antibacterial efficacy.

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Dissertations / Theses on the topic "Phenothiazines"

1

Ahmed, A. M. S. "Micellization of phenothiazines and their interaction with liposomes." Thesis, Cardiff University, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.372325.

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Drummond, Patricia Mary. "A comparative photostability study of four propyl piperzine-substituted phenothiazines." Thesis, Rhodes University, 1997. http://hdl.handle.net/10962/d1003234.

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Four structurally related phenothiazines available in South Africa in a variety of dosage forms and as fine chemicals were investigated to ascertain whether their structural differences in terms of the 2-chloro-/ trifluoromethyl-substituents on the phenothiazine nucleus and the methyl-/ ß-hydroxethyl groups on the piperazine ring accouning for the differences in pharmacological activity can be correlated with their photostability².The four propyl piperazine-substituted derivatives are ranked in the following decreasing order of neuroleptic activity: fluphenazine> trifluoperazine> perphenazine

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Dunbar, Philip Gordon. "Approaches to the synthesis of pentacyclic dibenzazepines and phenothiazines." Diss., The University of Arizona, 1987. http://hdl.handle.net/10150/184295.

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Rigid analogues of the tricyclic antidepressant imipramine and the phenothiazine tranquilizer promazine were designed and their syntheses were attempted. Conformational rigidity was expected to reduce the side effects of these drugs by limiting their binding to multiple receptors. Ortho-directed metalation followed by acylation provided synthetic intermediates for the formation of the desired pentacyclic congeners. The known dilithiation of phenothiazine and iminodibenzyl and n-butyllithium, followed by acylation with dimethylformamide, gave carboxaldehydes at the 1 and 4 positions respectivel

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Ferrara, Daro 1961. "DETECTION OF PHENOTHIAZINES USING COATED WIRE ION-SELECTIVE ELECTRODES." Thesis, The University of Arizona, 1986. http://hdl.handle.net/10150/276493.

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Omoruyi, Sylvester Ifeanyi. "Investigating the anti-cancer activity of novel phenothiazines in glioblastoma." University of the Western Cape, 2018. http://hdl.handle.net/11394/6329.

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Philosophiae Doctor - PhD<br>Glioblastoma multiforme (GBM) remains the most malignant of all primary adult brain tumours. It is a highly invasive and vascularized neoplasm with limited treatment options and very low survival rate. GBM tumours are heterogeneous in nature with cellular hierarchy and at the apex of this hierarchy are the glioblastoma stem cells, known to promote tumourigenesis and resistance to chemotherapeutic agents and tumour recurrence. Currently, the standard care for GBM involves surgical resection, radiation, and chemotherapy treatment with temozolomide. Unfortunately, med

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GUEVARA, ELMER AUGUSTO CUEVA. "FOTODEGRADATION OF PHENOTHIAZINES AND THEIR STRUCTURAL EFFECTS ON NA(+)K(+) - ATPASE: A FLUORESCENCE STUDY." PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 2010. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=15952@1.

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CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO<br>Clorpromazina (CPZ), flufenazina (FPZ) e trifluperazina (TFP) são derivados de fenotiazinas que, sob irradiação UV, geram fotoprodutos. Observouse que CPZ desenvolve três fotoprodutos fluorescentes em diferentes condições. A promazina (PZ) se forma da fotólise de CPZ pela quebra da ligação com o cloro. A saída do cloro é um dos principais caminhos para a formação de outros fotoprodutos, sendo também um requisito para formação de dímeros e trímeros de CPZ. O segundo produto fluorescente é a espécie sulfóxida, que se desenvolve em

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7

Fenart, Naud Dominique. "La photosensibilite au neuriplege : a propos de 8 observations, photo-allergie croisee entre la chlorproethazine et les autres phenothiazines." Lille 2, 1988. http://www.theses.fr/1988LIL2M103.

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Semenya, Manare Molahlegi Dorothy. "Non-Neuroleptic Antitubercular and Anticancer Therapeutics through Rational Drug Remodelling of Phenothiazines and Related Antipsychotics." Thesis, Faculty of Science, 2021. http://hdl.handle.net/11427/33391.

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In light of shrinking pharmaceutical drug pipelines and drug resistance, innovative drug discovery strategies are of imperative need. Drug repurposing and related strategies such as drug rescue and drug remodelling have garnered significant research interest. Various clinically approved non-antibiotics including phenothiazines hold promise as novel classes of therapeutics in other indications. However, in addition to inherent neuroleptic properties, phenothiazines and related antipsychotics elicit adverse side effects at clinically relevant doses thus precluding their extensive clinical applic

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Abouamer, Karima Massaud. "Application of natural dyes in textile industry and the treatment of dye solutions using electrolytic techniques." Thesis, Brunel University, 2008. http://bura.brunel.ac.uk/handle/2438/5088.

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Anodic oxidation of a commercial dye, methylene blue (MB), from aqueous solutions using an electrochemical cell is reported. Data are provided on the effects of eight different types of supporting electrolytes, concentration of electrolytes, initial dye concentration, current and electrolytic time on the percentage removal of methylene blue. Anodic oxidation was found to be effective in achieving the removal of methylene blue from aqueous solutions. The optimised electrolytic conditions, for the removal of methylene blue (MB), were applied to the removal of azure A (AA), azure B (AB), azure C

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10

LAASSIS, BELKACEM. "Etude de la fluorescence photoinduite d'une serie de phenothiazines en solution aqueuse et en presence de cyclodextrines - applications analytiques et pharmaceutiques." Paris 7, 1997. http://www.theses.fr/1997PA077047.

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Un groupe de phenothiazines a ete quantifie par application des methodes analytiques basees sur la fluorescence. Les mesures directes de la fluorescence native de ces composes n'ont donne que des performances analytiques mediocres avec des limites de detection de l'ordre de 10 a 110 ng/ml, mais leur photooxydation sous l'effet d'irradiation uv provoque une augmentation importante du signal de fluorescence, ce qui permet de developper une methode fluorimetrique photoinduite (pif) sensible, dans les conditions optimales de solvant (eau), ph et de temps d'irradiation. Les phenothiazines ont ete a

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Books on the topic "Phenothiazines"

1

1941-, Gupta R. R., ed. Phenothiazines and 1,4-benzothiazines: Chemical and biomedical aspects. Elsevier, 1988.

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2

International Conference on Phenothiazines and Structurally Related Psychotropic Compounds (6th 1990 Pasadena, Calif.). Thiazines and structurally related compounds: Proceedings of the Sixth International Conference on Phenothiazines and Structurally Related Psychotropic Compounds, Pasadena, California, September 11-14, 1990. Edited by Keyzer Hendrik and Eckert George M. Krieger Pub. Co., 1992.

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3

Ghuwar, Ramadan. Aspects of the analytical chemistry of phenothiazine drugs. University of Salford, 1995.

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Keyzer, Hendrik. Thiazines and Structurally Related Compounds: Proceedings of the Sixth International Conference on Phenothiazines and Structually Related Psychotrop. Krieger Pub Co, 1992.

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5

Allenby, Gordon Micheal. Binding of Phenothiazine Derivatives by Proteins and Nucleic Acid, and the Effect of Phenothiazine and Phenothiazine Derivatives on Some Respiratory Enzymes. Creative Media Partners, LLC, 2021.

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6

The 2006-2011 World Outlook for Psychotherapeutic Tranquilizing Agents Excluding Phenothiazine Derivatives. Icon Group International, Inc., 2005.

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Parker, Philip M. The 2007-2012 World Outlook for Psychotherapeutic Tranquilizing Agents Excluding Phenothiazine Derivatives. ICON Group International, Inc., 2006.

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Amma, Manju Thankamoni. Mechanistic investigations on the reactivity of 10-methyl phenothiazine with singlet oxygen. 2006.

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9

Parker, Philip M. The 2007-2012 Outlook for Psychotherapeutic Tranquilizing Agents Excluding Phenothiazine Derivatives in India. ICON Group International, Inc., 2006.

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Parker, Philip M. The 2007-2012 Outlook for Psychotherapeutic Tranquilizing Agents Excluding Phenothiazine Derivatives in Japan. ICON Group International, Inc., 2006.

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Book chapters on the topic "Phenothiazines"

1

McAllister-Williams, R. Hamish, Daniel Bertrand, Hans Rollema, et al. "Phenothiazines." In Encyclopedia of Psychopharmacology. Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-68706-1_1053.

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2

Kurihara, Teruo, Kazumi Shinohara, Makoto Inabe, et al. "Theoretical Studies on Phenothiazines, Benzo[a]phenothiazines, and Benz[c]acridines." In Topics in Heterocyclic Chemistry. Springer Berlin Heidelberg, 2008. http://dx.doi.org/10.1007/7081_2007_090.

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3

Laux, Gerd. "Piperazine Phenothiazines: Fluphenazine and Perphenazine." In NeuroPsychopharmacotherapy. Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-62059-2_474.

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Laux, Gerd. "Piperazine Phenothiazines: Fluphenazine and Perphenazine." In NeuroPsychopharmacotherapy. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-319-56015-1_474-1.

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Aaron, J. J., M. D. Gaye Seye, S. Trajkovska, and N. Motohashi. "Bioactive Phenothiazines and Benzo[a]phenothiazines: Spectroscopic Studies, and Biological and Biomedical Properties and Applications." In Topics in Heterocyclic Chemistry. Springer Berlin Heidelberg, 2008. http://dx.doi.org/10.1007/7081_2008_125.

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McKay, G., S. F. Cooper, and K. K. Midha. "Determination of Phenothiazines: The Present-Day Scene." In BIOACTIVE ANALYTES, Including CNS Drugs, Peptides, and Enantiomers. Springer US, 1986. http://dx.doi.org/10.1007/978-1-4757-1892-8_14.

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Beckett, A. H. "Separation and Detection of Unstable Metabolites of Amphetamines, Analgesics and Phenothiazines." In Ciba Foundation Symposium 26 - The Poisoned Patient: The Role of the Laboratory. John Wiley & Sons, Ltd., 2008. http://dx.doi.org/10.1002/9780470720080.ch5.

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Rao, M. L., M. Bagli, J. Fritze, G. Laux, and P. König. "Phenothiazine." In Neuro-Psychopharmaka Ein Therapie-Handbuch. Springer Vienna, 1998. http://dx.doi.org/10.1007/978-3-7091-6458-7_5.

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Scahill, Lawrence David. "Phenothiazine." In Encyclopedia of Autism Spectrum Disorders. Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4419-1698-3_1254.

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Scahill, Lawrence David. "Phenothiazine." In Encyclopedia of Autism Spectrum Disorders. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-319-91280-6_1254.

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Conference papers on the topic "Phenothiazines"

1

Blaja, Svetlana, Lidia Lungu, Kaleria Kuchkova, Alexandru Ciocarlan, and Aculina Aricu. "Synthesis of new molecular hybrids with phenothiazine fragment from norambreinolide." In Scientific seminar with international participation "New frontiers in natural product chemistry". Institute of Chemistry, Republic of Moldova, 2023. http://dx.doi.org/10.19261/nfnpc.2023.ab10.

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The known phenothiazine derivatives exhibit a wide spectrum of biological activities, including such as antiparasitic, antioxidant, anticancer, antiproliferative, antineoplastic, antimicrobial, etc. [1]. For this reason, terpeno-phenothiazine molecular hybrids represent one of the priority strategies of organic synthesis in the design of new bioactive compounds. Here are reported the results of the synthesis of new homodrimane hybrids with a phenothiazine fragment. Starting from (+)-sclareolide 1 the Δ8,13-bicyclohomofarnesoic acid 2 and 11-homodrim-6(8)-dien-12-oic acid 3 were synthesized in

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2

Müller, Thomas, and Christa Kramer. "Syntheses of Functionalized Alkynylated Phenothiazines." In The 4th International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2000. http://dx.doi.org/10.3390/ecsoc-4-01856.

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Sharma, Sadhna, and Amandeep Singh. "Chemotherapeutic Implications Of Phenothiazines Against Experimental Tuberculosis." In American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California. American Thoracic Society, 2012. http://dx.doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a4255.

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Tasi, Gyula, István Pálinko, Levente Nyerges, István Farkas, and Imre Labádi. "Similarity study of phenothiazines using molecular electrostatic potential maps." In The first European conference on computational chemistry (E.C.C.C.1). AIP, 1995. http://dx.doi.org/10.1063/1.47822.

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Cibotaru, Sandu, Andreea-Isabela Sandu, Dalila Belei, and Luminita Marin. "Water Soluble PEGylated phenothiazines. Synthesis, Characterization and Antitumor Properties." In The First International Conference on “Green” Polymer Materials 2020. MDPI, 2020. http://dx.doi.org/10.3390/cgpm2020-07215.

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Oliveira, Susana C. P. S., Gustavo M. P. Santos, Juliana S. C. Monteiro, et al. "Photodynamic antimicrobial chemotherapy (PACT) using phenothiazines derivatives associated with the red laser againststaphylococcus aureus." In SPIE BiOS, edited by Michael R. Hamblin, James D. Carroll, and Praveen R. Arany. SPIE, 2013. http://dx.doi.org/10.1117/12.2005560.

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Monteiro, Juliana S. C., Susana C. P. S. Oliveira, Gustavo M. P. Santos, et al. "Photodynamic antimicrobial chemotherapy (PACT) using phenothiazines derivatives associated with the red-orange LED againststaphylococcus aureus." In SPIE BiOS, edited by Michael R. Hamblin, James D. Carroll, and Praveen R. Arany. SPIE, 2013. http://dx.doi.org/10.1117/12.2005591.

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Haag, Petra, Katarzyna Zielinska-Chomej, Therese Juntti, et al. "Abstract B19: Phenothiazines induce cytotoxicity and enhance chemotherapy-induced cell death signaling in acute myeloid leukemia." In Abstracts: AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics--Oct 19-23, 2013; Boston, MA. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1535-7163.targ-13-b19.

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de Oliveira, Susana C. P. S., Juliana S. C. Monteiro, Gustavo M. Pires-Santos, et al. "In vitro influence of photodynamic antimicrobial chemotherapy onstaphylococcus aureusby using phenothiazines derivatives associated with laser/LED light." In SPIE BiOS, edited by Michael R. Hamblin, James D. Carroll, and Praveen Arany. SPIE, 2014. http://dx.doi.org/10.1117/12.2038576.

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Vesenbeckh, Silvan, David Krieger, Gudrun Bettermann, et al. "Neuroleptic drugs as potential adjuvants in the treatment of MDR-TB: Minimal inhibitory concentrations (MICs) of different phenothiazines againstM. tuberculosis." In Annual Congress 2015. European Respiratory Society, 2015. http://dx.doi.org/10.1183/13993003.congress-2015.pa3329.

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