Log in

Relevant bibliographies by topics / Phenyl Coumarin / Journal articles

To see the other types of publications on this topic, follow the link: Phenyl Coumarin.

Journal articles on the topic 'Phenyl Coumarin'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Phenyl Coumarin.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Bhila, Varun G., Yogita L. Chovatiya, Chirag V. Patel, Rakesh R. Giri, and Dinkar I. Brahmbhatt. "A Convergent Approach for the Synthesis of New Pyrazolyl Bipyridinyl Substituted Coumarin Derivatives as Antimicrobials." International Letters of Chemistry, Physics and Astronomy 40 (October 2014): 1–16. http://dx.doi.org/10.18052/www.scipress.com/ilcpa.40.1.

Full text

Abstract:

Some new 3-[3-(1-phenyl-3-aryl-1H-pyrazol-4-yl) acryloyl] coumarins 3a-f were synthesized (coumarin chalcones) by the condensation of various 3-acetyl coumarins 1 and appropriate 1-phenyl-3-aryl-1H-pyrazole-4-carbaldehyde 2. These coumarin chalcones 3a-f were then employed for the synthesis of pyrazolyl bipyridinyl substituted coumarins 7a-f, 8a-f, and 9a-f under Krohnke’s reaction condition. The characterization of all the synthesized compounds was carried out by elemental analysis, IR, 1H-NMR, 13C-NMR, DEPT-135 and mass spectral analysis. In addition to that, in vitro antimicrobial competenc

APA, Harvard, Vancouver, ISO, and other styles

2

Bhila, Varun G., Yogita L. Chovatiya, Chirag V. Patel, Rakesh R. Giri, and Dinkar I. Brahmbhatt. "A Convergent Approach for the Synthesis of New Pyrazolyl Bipyridinyl Substituted Coumarin Derivatives as Antimicrobials." International Letters of Chemistry, Physics and Astronomy 40 (October 23, 2014): 1–16. http://dx.doi.org/10.56431/p-y6404d.

Full text

Abstract:

Some new 3-[3-(1-phenyl-3-aryl-1H-pyrazol-4-yl) acryloyl] coumarins 3a-f were synthesized (coumarin chalcones) by the condensation of various 3-acetyl coumarins 1 and appropriate 1-phenyl-3-aryl-1H-pyrazole-4-carbaldehyde 2. These coumarin chalcones 3a-f were then employed for the synthesis of pyrazolyl bipyridinyl substituted coumarins 7a-f, 8a-f, and 9a-f under Krohnke’s reaction condition. The characterization of all the synthesized compounds was carried out by elemental analysis, IR, 1H-NMR, 13C-NMR, DEPT-135 and mass spectral analysis. In addition to that, in vitro antimicrobial competenc

APA, Harvard, Vancouver, ISO, and other styles

3

Mahajan, Jaswant R., and Hugo C. Araújo. "Attempted novel preparation of dihydrocoumarin and coumarin; obtention of aryl acrylates and 3-chloropropionates." Canadian Journal of Chemistry 65, no. 1 (1987): 224–25. http://dx.doi.org/10.1139/v87-035.

Full text

Abstract:

It has been found that, contrary to the published report, there is no noticeable reaction between phenol and methyl acrylate in the presence of aluminum chloride to produce phenyl acrylate (1) and dihydrocoumarin (2). Although products having the reported spectral data can be obtained by the reaction of phenol with acrylyl chloride, these products are actually phenyl acrylate and phenyl 3-chloropropionate (4), there being detected no dihydrocoumarin. This reaction has now been extended to several substituted phenols and some naphthols. Attempts at cyclization of phenyl acrylate, phenyl 3-chlor

APA, Harvard, Vancouver, ISO, and other styles

4

Sharapov, A. D., R. F. Fatykhov, I. A. Khalymbadzha, A. P. Potapova, P. A. Slepukhin, and O. N. Chupakhin. "Unusual nicotinoylation of 4-phenyl-5,7-dihydroxycoumarin." Chimica Techno Acta 9, no. 1 (2022): 20229105. http://dx.doi.org/10.15826/chimtech.2022.9.1.05.

Full text

Abstract:

In the present work, we report a convenient synthesis of 5- and 7-substituted-4-phenyl coumarins. In contrast to previous results obtained with 4-alkylcoumarins, nicotinoylation of 5,7-dihydroxy-4-phenylcoumarin with nicotinoyl benzotriazole or nicotinoyl azide selectively provides 5-O protected ester. The combination of the nicotinoylation reaction followed by tosylation-denicotinoylation yields 5-hydroxy-7-tosyloxy-coumarin derivative, which may be useful in the synthesis of inophyllum, a tetracyclic HIV reverse transcriptase inhibitor, as well as its analogues.

APA, Harvard, Vancouver, ISO, and other styles

5

Quezada, Elías, Fernanda Rodríguez-Enríquez, Reyes Laguna, et al. "Curcumin–Coumarin Hybrid Analogues as Multitarget Agents in Neurodegenerative Disorders." Molecules 26, no. 15 (2021): 4550. http://dx.doi.org/10.3390/molecules26154550.

Full text

Abstract:

Neurodegenerative diseases have a complex nature which highlights the need for multitarget ligands to address the complementary pathways involved in these diseases. Over the last decade, many innovative curcumin-based compounds have been designed and synthesized, searching for new derivatives having anti-amyloidogenic, inhibitory of tau formation, as well as anti-neuroinflammation, antioxidative, and AChE inhibitory activities. Regarding our experience studying 3-substituted coumarins with interesting properties for neurodegenerative diseases, our aim was to synthesize a new series of curcumin

APA, Harvard, Vancouver, ISO, and other styles

6

ADSULE, PRAJAKTA, Dishank Purandare, S. KULKARNI, R. JOSHI, and A. CHABUKSWAR. "Synthesis and Evaluation of Analgesic and Antioxidant Activity of 3-Phenyl Coumarin Derivatives." Asian Journal of Chemistry 35, no. 9 (2023): 2109–14. http://dx.doi.org/10.14233/ajchem.2023.28059.

Full text

Abstract:

A series of 3- phenyl substituted coumarin derivatives prepared by reacting substituted aromatic aldehyde with phenylacetic acid. The chemical composition of substituted coumarin derivatives was confirmed by FT-IR, 1H NMR spectra and elemental analysis. Designed 3-phenyl coumarin derivatives were docked with Cyclooxygenase-2 (COX-2) enzyme (PDB CODE: 3Q7D). Compounds were synthesized and evaluated for in-vivo analgesic and in-vitro antioxidant activities depending upon the highest binding affinity. Compounds 02, 10, and 11 exhibited significant analgesic activity. Compounds 09, 04, 01, and 03

APA, Harvard, Vancouver, ISO, and other styles

7

Lipeeva, Alla V., Danila O. Zakharov, Liubov G. Burova, et al. "Design, Synthesis and Antibacterial Activity of Coumarin-1,2,3-triazole Hybrids Obtained from Natural Furocoumarin Peucedanin." Molecules 24, no. 11 (2019): 2126. http://dx.doi.org/10.3390/molecules24112126.

Full text

Abstract:

Synthesis of 1,2,3-triazole-substituted coumarins and also 1,2,3-triazolyl or 1,2,3-triazolylalk-1-inyl-linked coumarin-2,3-furocoumarin hybrids was performed by employing the cross-coupling and copper catalyzed azide-alkyne cycloaddition reaction approaches. The synthesized compounds were evaluated for their in vitro antibacterial activity against Staphylococcus aureus, Bacillius subtilis, Actinomyces viscosus and Escherichia coli bacterial strains. Coumarin-benzoic acid hybrids 4с, 42с and 3-((4-acetylamino-3-(methoxycarbonyl)phenyl)ethynyl)coumarin (29) showed promising activity against S.

APA, Harvard, Vancouver, ISO, and other styles

8

Guan, Ai-Ying, Chang-Ling Liu, Miao Li, Zhi-Nian Li, Ming-Xing Zhang, and Hong Zhang. "Synthesis and Bioactivity of Novel Coumarin Derivatives." Natural Product Communications 6, no. 12 (2011): 1934578X1100601. http://dx.doi.org/10.1177/1934578x1100601232.

Full text

Abstract:

A series of coumarin derivatives (6-8) containing ( E)-methyl 2-(methoxyimino)-2-phenylacetate, ( E)-2-(methoxyimino )-N-methyl-2-phenylacetamide and methyl methoxy(phenyl)carbamate were synthesized from substituted resorcinols (1) and substituted β-keto esters (2) as starting material via cyclization and condensation reactions. The test results indicated that ( E)-methyl 2-{2-[(3-hexyl-4-methyl-coumarin-7-yloxy)methyl]phenyl}-2-(methoxyimino)acetate (6f) was the optimal structure with good fungicidal activity against cucumber grey mold (CGM) giving 100% control at 100 mg L−1 concentration, mu

APA, Harvard, Vancouver, ISO, and other styles

9

Kothavale, Shantaram, and Nagaiyan Sekar. "A new type of triphenylamine based coumarin–rhodamine hybrid compound: synthesis, photophysical properties, viscosity sensitivity and energy transfer." RSC Advances 6, no. 107 (2016): 105387–97. http://dx.doi.org/10.1039/c6ra24485h.

Full text

Abstract:

A series of novel core modified triphenylamine coumarin–rhodamine systems (compounds MCMR, MCDR and DCMR) was designed and synthesized by incorporating a coumarin moiety on one and a rhodamine moiety on the other phenyl ring of the triphenylamine molecular skeleton.

APA, Harvard, Vancouver, ISO, and other styles

10

Dr., Neha N. Gohil, and D. I. Brahmbhatt Dr. "Synthesis, Characterization and In Vitro Antimicrobial Screening of Some PyrazolylPyridyl Substituted Dicoumarins." International Journal of Trend in Scientific Research and Development 2, no. 4 (2018): 1692–705. https://doi.org/10.31142/ijtsrd14420.

Full text

Abstract:

In the present study, a series of pyrazolyl pyridyl substituted dicoumarins has been synthesized. The synthesis of various 3,3 4 1 phenyl 3 pyridin 3 yl 1H pyrazol 4 yl pyridine 2,6 diyl dicoumarins and 3,3 4 1 phenyl 3 pyridin 4 yl 1H pyrazol 4 yl pyridine 2,6 diyl dicoumarins has been carried out by the reaction of various 3 coumarinoyl methyl pyridinium bromide salts with 3 3 1 phenyl 3 pyridin 3 yl 1H pyrazol 4 yl acryloyl coumarins and 3 3 1 phenyl 3 pyridin 4 yl 1H pyrazol 4 yl acryloyl coumarins coumarin chalcones respectively under Krohnke's reaction condition. Structural assignmen

APA, Harvard, Vancouver, ISO, and other styles

11

Bedernichek, Tymur, Natalia Zaimenko, Roman Ivannikov, et al. "Content of low-molecular-weight organic compounds in soils under Deschampsia antarctica and D. cespitosa (Poaceae)." Ukrainian Antarctic Journal 16 (December 3, 2018): 123–28. https://doi.org/10.5281/zenodo.2532072.

Full text

Abstract:

Antarctic hairgrass <em>Desсhampsia antarctica</em> (<em>Poaceae</em>) is an important ecosystem engineer in coastal Antarctica and significantly affects properties and composition of soil organic matter. The objective of this study was to determine content and composition of low-molecular-weight organic compounds in humus-turf horizon of leptosol under <em>D. antarctica</em> and in alfisol under <em>D. cespitosa</em>. Comparison of soil organic matter under these closely related species is important to find the markers typical for Antarctic soils only. Methods of high-performance liquid chrom

APA, Harvard, Vancouver, ISO, and other styles

12

Shahi, Akbar Massoumi, Mohammad Nikpassand, and Leila Zare Fekri. "Acidic Ionic Liquid-catalyzed Synthesis of Pyrano[4,3-b]pyran-5(4H)-ones using 4,4,4-trifluoro-1-phenylbutane-1,3-dione as a Building Block." Current Organic Synthesis 17, no. 8 (2020): 648–53. http://dx.doi.org/10.2174/1570179417666200520111536.

Full text

Abstract:

Aims: synthesis of pyrano[c-2,3]chromens with Ionic Liquid catalyst with simple method. Background: Synthesis of pyrano[c]coumarins has a special place in the structure due to two bioactive compounds in its structure and attracts a great deal of attention in this research work, it has been attempted to attach chromatically valuable skeletons to them and synthesize the pyrano [c] coumarines, which can potentially have high biological properties. For this purpose, electrophilic β-ketoester ringing in the presence of ionic liquid catalysts was used. While optimizing the catalyst recovery, it is p

APA, Harvard, Vancouver, ISO, and other styles

13

Yılmaz, Fatih, and Emre Menteşe. "Synthesis and Characterisation of Some Coumarin-1,2,4-Triazol-3-Thioether Hybrid Molecules." Journal of Chemical Research 41, no. 1 (2017): 4–6. http://dx.doi.org/10.3184/174751917x14815427219040.

Full text

Abstract:

A new series of N′-{[(4-methyl/phenyl-5-phenyl-4 H-1,2,4-triazol-3-yl)thio]acetyl}-2-oxo-2 H-chromene-3-carbohydrazides was synthesised via the reaction of 2-[(4-methyl/phenyl-5-phenyl-4 H-1,2,4-triazol-3-yl)thio]acetohydrazides and 3-(1 H-benzotriazol-1-ylcarbonyl)-2 H-chromen-2-ones in good yields.

APA, Harvard, Vancouver, ISO, and other styles

14

Arumugam, S., and C. L. Khetrapal. "Nuclear magnetic resonance spectra of oriented bicyclic systems containing heteroatom(s): the spectrum of 2-thiocoumarin." Canadian Journal of Chemistry 64, no. 4 (1986): 714–16. http://dx.doi.org/10.1139/v86-114.

Full text

Abstract:

From the proton nmr studies of 2-thiocoumarin and coumarin, it is concluded that the relative interproton distances in the two oxygen heteroatom bicyclic systems are similar. The values for the phenyl ring protons do not deviate significantly from the regular hexagonal geometry, unlike bicyclic systems with nitrogens as the heteroatoms, such as diazanaphthalenes. Larger values of the indirect spin–spin couplings within the protons of the ring containing the oxygen heteroatom, compared to the values between the ortho protons in the phenyl rings in coumarin and 2-thiocoumarin, correspond to the

APA, Harvard, Vancouver, ISO, and other styles

15

Gaber, Ahmed, Walaa F. Alsanie, Majid Alhomrani, Abdulhakeem S. Alamri, Ibrahim M. El-Deen, and Moamen S. Refat. "Synthesis and Characterization of Some New Coumarin Derivatives as Probable Breast Anticancer MCF-7 Drugs." Crystals 11, no. 5 (2021): 565. http://dx.doi.org/10.3390/cryst11050565.

Full text

Abstract:

This study aimed to synthesize quinolinone derivatives and investigate their cytotoxic activity. The compound 1-azacoumarin-3-carboxylic acid (2-oxo-1H-quinoline-3-carboxylic acid) was obtained via the cyclocondensation of 2-hydroxybenzaldehyde with diethyl malonate in base catalyst to give ethyl coumarin-3-carboxylate, followed by the ammonolysis of ester (ethyl coumarin-3-carboxylate) with ammonia in the presence of anhydrous potassium carbonate. Treatment of 2-oxo-1H-quinoline-3-carboxylic acid with acetic anhydride, cinnamaldehyde, cinnamic acid and methyl 5-phenyl-2-cyano-2,4-pentadienoat

APA, Harvard, Vancouver, ISO, and other styles

16

Katopodi, Annita, Evangelia Tsotsou, Triantafylia Iliou, et al. "Synthesis, Bioactivity, Pharmacokinetic and Biomimetic Properties of Multi-Substituted Coumarin Derivatives." Molecules 26, no. 19 (2021): 5999. http://dx.doi.org/10.3390/molecules26195999.

Full text

Abstract:

A series of novel multi-substituted coumarin derivatives were synthesized, spectroscopically characterized, and evaluated for their antioxidant activity, soybean lipoxygenase (LOX) inhibitory ability, their influence on cell viability in immortalized human keratinocytes (HaCaT), and cytotoxicity in adenocarcinomic human alveolar basal epithelial cells (A549) and human melanoma (A375) cells, in vitro. Coumarin analogues 4a–4f, bearing a hydroxyl group at position 5 of the coumarin scaffold and halogen substituents at the 3-phenyl ring, were the most promising ABTS•+ scavengers. 6,8-Dibromo-3-(4

APA, Harvard, Vancouver, ISO, and other styles

17

Lu, Ping-Hsun, Tzu-Hsien Liao, Yau-Hung Chen, et al. "Coumarin Derivatives Inhibit ADP-Induced Platelet Activation and Aggregation." Molecules 27, no. 13 (2022): 4054. http://dx.doi.org/10.3390/molecules27134054.

Full text

Abstract:

Coumarin was first discovered in Tonka bean and then widely in other plants. Coumarin has an anticoagulant effect, and its derivative, warfarin, is a vitamin K analogue that inhibits the synthesis of clotting factors and is more widely used in the clinical treatment of endovascular embolism. At present, many artificial chemical synthesis methods can be used to modify the structure of coumarin to develop many effective drugs with low toxicity. In this study, we investigated the effects of six coumarin derivatives on the platelet aggregation induced by adenosine diphosphate (ADP). We found that

APA, Harvard, Vancouver, ISO, and other styles

18

Safakish, Mahdieh, Zahra Hajimahdi, Mohammad R. Aghasadeghi, Rouhollah Vahabpour, and Afshin Zarghi. "Design, Synthesis, Molecular Modeling and Anti-HIV Assay of Novel Quinazolinone Incorporated Coumarin Derivatives." Current HIV Research 18, no. 1 (2020): 41–51. http://dx.doi.org/10.2174/1570162x17666191210105809.

Full text

Abstract:

Background: The emergence of drug-resistant viral strains has created the need for the development of novel anti-HIV agents with a diverse structure that targets key enzymes in the HIV lifecycle. Objective: Considering the pharmacophore of integrase inhibitors, one of the validated targets for anti-HIV therapy, we designed a quinazolinone incorporated coumarin scaffold to affect HIV. Method: Coumarin is a beta enol ester and also a well-known drug scaffold. Designed structures were prepared using a one-pot three-compo Results: In vitro anti-HIV and cytotoxicity assay indicated that more than h

APA, Harvard, Vancouver, ISO, and other styles

19

Devi, Sarika, Pooja Singh, Vaibhav Rathi, and Praveen Kumar. "In vitro Evaluation (Antioxidant Activity) of coumarin derivatives." Research Journal of Chemistry and Environment 26, no. 7 (2022): 145–52. http://dx.doi.org/10.25303/2607rjce145152.

Full text

Abstract:

Coumarin is a heterocyclic molecule associated with beneficial human health effects such as to reduce the risk of cancer, diabetes, cardiovascular and brain disease. These effects are thought to be related to free radical scavenging due to their antioxidant properties. Coumarin is a substance that has been synthesized in many of its derivatives in recent years. This entity is a major source of interest for many medicinal chemists to explore its various pharmacological possibilities, especially anticoagulant activity. The antioxidant activities of two synthesized coumarin derivatives namely 2-(

APA, Harvard, Vancouver, ISO, and other styles

20

Abbas, Jamilah, and Syafruddin Syafruddin. "Antiplasmodial Evaluation of One Compound from Calophyllum flavoranulum." Indonesian Journal of Chemistry 14, no. 2 (2014): 185–91. http://dx.doi.org/10.22146/ijc.21257.

Full text

Abstract:

Calophyllum flavoranulum (Clusiaceae family) is a big tree and medical plants from the tropical rain forest of the Indonesian continent. The organic extracts from stem bark yielded phenyl coumarin. The structure was elucidated with the aid of spectroscopic technique. Antiplasmodial activities of isolated compound was tested in vivo against Plasmodium berghei parasite and showed the best antiplasmodial activity. New flavoranulum coumarin compound showed activity against P. berghei parasite with inhibition growth 0, 31.33, 40, 30.67, 46 and 34% at dosage 1.1x10-10, 1.1x10-9, 1.1x10-8, 1.1x10-7,

APA, Harvard, Vancouver, ISO, and other styles

21

Walki, Shashikanth, S. Naveen, S. Kenchanna, K. M. Mahadevan, M. N. Kumara, and N. K. Lokanath. "Crystal structure of 8-ethoxy-3-(4-nitrophenyl)-2H-chromen-2-one." Acta Crystallographica Section E Crystallographic Communications 71, no. 11 (2015): o860—o861. http://dx.doi.org/10.1107/s2056989015019325.

Full text

Abstract:

In the title compound, C17H13NO5, the coumarin ring system is essentially planar (r.m.s. deviation = 0.008 Å). The nitrophenyl ring makes a dihedral angle of 25.27 (9)° with the coumarin ring plane. The nitro group is almost coplanar with the phenyl ring to which it is attached, making a dihedral angle of 4.3 (3)°. The ethoxy group is inclined to the coumarin ring plane by 4.1 (2)°. Electron delocalization was found at the short bridging C—C bond with a bond length of 1.354 (2) Å. In the crystal, molecules are linkedviaC—H...O hydrogen bonds, forming sheets in thebcplane. The sheets are linked

APA, Harvard, Vancouver, ISO, and other styles

22

Danis, Ozkan, Basak Yuce-Dursun, Cihan Gunduz, et al. "Synthesis of 3-amino-4-hydroxy coumarin and dihydroxy-phenyl coumarins as novel anticoagulants." Arzneimittelforschung 60, no. 10 (2011): 617–20. http://dx.doi.org/10.1055/s-0031-1296335.

Full text

APA, Harvard, Vancouver, ISO, and other styles

23

Bylov, I. E. "Synthesis of phenyl esters 2-oxo-2H-1-benzopyran-3-carboxylic acids as promising antimicrobial agents." Voprosy Khimii i Khimicheskoi Tekhnologii, no. 3 (July 2024): 30–36. http://dx.doi.org/10.32434/0321-4095-2024-154-3-30-36.

Full text

Abstract:

Corresponding chloroanhydrides were synthesized by the interaction of coumarin-3-carboxylic and 6-methoxycoumarin-3-carboxylic acids with an excess of thionyl chloride under heating. Due to the quantitative yields and the formation of volatile products within the reaction, chloroanhydrides were used without additional purification in acylation of substituted phenols for the synthesis of phenyl esters of 2-oxo-2H-1-benzopyran-3-carboxylic acids. The reaction was carried out by heating in anhydrous dioxane environment in the presence of pyridine as a catalyst. The structure of the obtained ester

APA, Harvard, Vancouver, ISO, and other styles

24

Veselinović, Jovana, Aleksandar Veselinović, Andrey Toropov, Alla Toropova, Ivana Damnjanović, and Goran Nikolić. "Monte Carlo Method Based QSAR Modeling of Coumarin Derivates as Potent HIV‐1 Integrase Inhibitors and Molecular Docking Studies of Selected 4‐phenyl Hydroxycoumarins." Acta Facultatis Medicae Naissensis 31, no. 2 (2014): 95–103. http://dx.doi.org/10.2478/afmnai-2014-0011.

Full text

Abstract:

Summary In search for new and promising coumarin compounds as HIV-1 integrase inhibitors, chemoinformatic methods like quantitative structure-activity relationships (QSAR) modeling and molecular docking have an important role since they can predict desired activity and propose molecule binding to enzyme. The aim of this study was building of QSAR models for coumarin derivatives as HIV-1 integrase inhibitors with the application of Monte Carlo method. SMILES notation was used to represent the molecular structure and for defining optimal SMILES-based descriptors. Molecular docking into rigid enz

APA, Harvard, Vancouver, ISO, and other styles

25

Liu, Chang-Ling, Miao Li, Ai-Ying Guan, Hong Zhang, and Zheng-Ming Li. "Design, Synthesis and Fungicidal Activity of Novel (E)-Methyl 2-{2-[(coumarin-7-yloxy)methyl]phenyl}-3-methoxyacrylates." Natural Product Communications 2, no. 8 (2007): 1934578X0700200. http://dx.doi.org/10.1177/1934578x0700200811.

Full text

Abstract:

A number of 7-hydroxycoumarins (5), on treatment with one equivalent of ( E)-methyl 2-{2-[(chloromethyl)phenyl]}-3-methoxyacrylate (6) at 80°C for 6–8 h, afforded ( E)-methyl 2-{2-[(coumarin-7-yloxy)methyl]phenyl}-3-methoxyacrylates (2) in 80–85% yields. The 7-hydroxycoumarins (5) were in turn prepared from resorcinols (3) and substituted ethyl 3-oxopropanoate (4). Subsequently, results of biological activities evaluated in the greenhouse indicated that several of these compounds have good fungicidal activity against cucumber downy mildew (CDM) at 25g ai/ha.

APA, Harvard, Vancouver, ISO, and other styles

26

Tahir, Tehreem, Muhammad Ashfaq, Humna Asghar, Mirza I. Shahzad, Rukhsana Tabassum, and Areeba Ashfaq. "Medicinal Importance of Azo and Hippuric Acid Derivatives." Mini-Reviews in Medicinal Chemistry 19, no. 9 (2019): 708–19. http://dx.doi.org/10.2174/1389557518666180727162018.

Full text

Abstract:

In this review, specific therapeutic and medicinal advantages including antiviral, antibacterial, antifungal and antitumor, strategies for drug designing, structure-activity relationship, advances in the syntheses of azo and hippuric acid derivatives of more than 50 compounds have been discussed since 2009-2018. It is found that phenyl-diazenyl azo derivatives and pyridinyl substituted hippuric acid derivatives showed promising antiretroviral potential. The incorporation of azo functionality to the respective quinolones and coumarin moieties and the insertion of thiocarbazone to hippuric acid

APA, Harvard, Vancouver, ISO, and other styles

27

Slimani, Ichraf, Naceur Hamdi, Sadeq M. Al-Hazmy, Ibrahim A. Alhagri, El-Zeiny M. Ebeid, and Ehab A. Okba. "Synthesis and Spectral Characterisation of (E)-3-(3-(4 (Dimethylamino)Phenyl)Acrylo-yl)-4-Hydroxy-2H-Chromen-2-One and Their Antibacterial Activity and Acetylcholinesterase Inhibition." Journal of Chemistry 2021 (December 7, 2021): 1–15. http://dx.doi.org/10.1155/2021/6101359.

Full text

Abstract:

A new coumarin derivative, (E)-3-(3-(4-(dimethylamino) phenyl) acrylo-yl)-4-hydroxy-2H-chromen-2-one (3), was synthesized by the condensation of 3-acetyl-4-hydroxycoumarin (1) with 4-N,N-dimethylaminobenzaldehyde (2) in the presence of piperidine in ethanol. The structure of the synthesized compound was characterized using spectroscopic data (IR and 1H NMR) and elemental analysis. The antimicrobial properties and acetylcholinesterase inhibition activity (AChEI) of coumarin 3 were investigated, with the highest observed AChEI activity providing 48.25% inhibition. The electronic absorption and e

APA, Harvard, Vancouver, ISO, and other styles

28

Mbaba, Mziyanda, Laura M. K. Dingle, Ayanda I. Zulu, et al. "Coumarin-Annulated Ferrocenyl 1,3-Oxazine Derivatives Possessing In Vitro Antimalarial and Antitrypanosomal Potency." Molecules 26, no. 5 (2021): 1333. http://dx.doi.org/10.3390/molecules26051333.

Full text

Abstract:

A tailored series of coumarin-based ferrocenyl 1,3-oxazine hybrid compounds was synthesized and investigated for potential antiparasitic activity, drawing inspiration from the established biological efficacy of the constituent chemical motifs. The structural identity of the synthesized compounds was confirmed by common spectroscopic techniques: NMR, HRMS and IR. Biological evaluation studies reveal that the compounds exhibit higher in vitro antiparasitic potency against the chemosensitive malarial strain (3D7 P. falciparum) over the investigated trypanosomiasis causal agent (T. b. brucei 427)

APA, Harvard, Vancouver, ISO, and other styles

29

Koszelewski, Dominik, Paweł Kowalczyk, Anna Brodzka, Anastasiia Hrunyk, Karol Kramkowski, and Ryszard Ostaszewski. "Enzymatic Synthesis of a Novel Coumarin Aminophosphonates: Antibacterial Effects and Oxidative Stress Modulation on Selected E. coli Strains." International Journal of Molecular Sciences 24, no. 8 (2023): 7609. http://dx.doi.org/10.3390/ijms24087609.

Full text

Abstract:

The objective of the present study was to evaluate the synergistic effect of two important pharmacophores, coumarin and α-amino dimethyl phosphonate moieties, on antimicrobial activity toward selected LPS-varied E. coli strains. Studied antimicrobial agents were prepared via a Kabachnik–Fields reaction promoted by lipases. The products were provided with an excellent yield (up to 92%) under mild, solvent- and metal-free conditions. A preliminary exploration of coumarin α-amino dimethyl phosphonate analogs as novel antimicrobial agents was carried out to determine the basic features of the stru

APA, Harvard, Vancouver, ISO, and other styles

30

A., S. A. YOUSSEF, A. KANDEEL K., and M. F. MADKOUR HASSAN. "Reactions of Carbon-Nucleophiles with Acetylenic Esters and Ketones." Journal of Indian Chemical Society Vol. 72, Feb 1995 (1995): 103–5. https://doi.org/10.5281/zenodo.5900950.

Full text

Abstract:

Chemistry Department, Faculty of Science, Ain Shams University, Abbassia, Cairo, Egypt <em>Manuscript received 27 April 1992, revised 29 September 1993, accepted 9 November 1993</em> Cyanoacetanilide (1) reacted with 3-phenyl-1-aryl-prop-2-yn-1-ones (2a-c) in the presence of sodium pellets in dry benzene to give the corresponding 3-cyanopyrid-2-ones (3a-c) and the aminopyrid-2-ones (4a,b). Similarly 1 reacted with methyl 3-arylprop-2-ynoates (2d,e) to give the 5-cyanopyrid-2-ones (7a,b) and the pyran-2-ones (8). On the other hand, 6-chloro-3-cyano-4-methylcoumarin (9) reacted with 2a-c,e to gi

APA, Harvard, Vancouver, ISO, and other styles

31

Chabukswar, Anuruddha, Prajakta V. Adsule, Swati Jagdale, Dishank V. Purandare, Kunal Raut, and Yash Kale. "Synthesis, Molecular Modeling and Cytotoxicity Study of New 3-Phenyl Coumarin Derivatives against in vitro Cell Lines." Asian Journal of Chemistry 36, no. 5 (2024): 1061–66. http://dx.doi.org/10.14233/ajchem.2024.31269.

Full text

Abstract:

In pursuit of more effective cancer treatments, researchers embarked on a study to enhance the coumarin derivative’s therapeutic potential. These compounds, known for their anticancer properties, have faced challenges such as increased toxicity and drug resistance. The research aimed to design, synthesize and assess new 3-phenyl coumarin derivatives specifically for breast and lung cancer treatment. Utilizing 3-oxoacyl-reductase (1T8I), a series of compounds were synthesized from aromatic aldehydes and phenylacetic acid. Among the synthesized 11 compounds that were examined, compounds C01, C04

APA, Harvard, Vancouver, ISO, and other styles

32

Chelamalla, Radhika, and Ajitha Makula. "Development of New IDO Inhibitors with Coumarin Pyrimidine Scaffolds as the Potential Anti Cancer Agents." Current Bioactive Compounds 16, no. 8 (2020): 1172–80. http://dx.doi.org/10.2174/1573407216666191216154856.

Full text

Abstract:

Background: Progress in the developments of pyrimidine-coumarin moiety as an IDO inhibitor is still continuing with an outcome of the good scaffold as pyrimidine as well as coumarin individually for anticancer activity. Hence we proposed a suitable approach for the synthesis of pyrimidinecoumarin moieties in a combined form from the results of docking studies. Objective: As part of our ongoing research towards the development of novel cytotoxic agents, the synthesis and cytotoxic activity of a series of N'-(1-(6-methyl-2-oxo/thioxo-4-sub phenyl-1,2,3,4- tetrahydropyrimidin-5-yl)vinyl)-2-oxo-2H

APA, Harvard, Vancouver, ISO, and other styles

33

Schaal, Janina, Nico Kotzur, Brigitte Dekowski, et al. "A novel photorearrangement of (coumarin-4-yl)methyl phenyl ethers." Journal of Photochemistry and Photobiology A: Chemistry 208, no. 2-3 (2009): 171–79. http://dx.doi.org/10.1016/j.jphotochem.2009.09.012.

Full text

APA, Harvard, Vancouver, ISO, and other styles

34

Vanam, Rateesh, Prasanna Bethanamudi, Ravinder M, and Amarnath Velidandi. "Synthesis Of Phenyl Tetrazolyl Hexa Hydropyranochromene Derivatives." Der Pharma Chemica 13, no. 2 (2021): 8. https://doi.org/10.5281/zenodo.14718250.

Full text

Abstract:

Novel series of bis-pyranotetrazole derivatives have been developed by using resorcinol as starting compound with involvement of substituted aromatic aldehydes (a-e), malononitrile in pot condensation. During the reaction 2,8-diamino-4,6-bis (substituted phenyl)-4,6-dihydropyrano[3,2- g] chromene-3,7-dicarbonitrile 1(a-e) and 2,8-dioxo-4,6-bis (substituted phenyl)-2,3,4,6,7,8-hexahydropyrano [3,2-g] chromene-3,7-dicarbonitrile 2(a-e) formed as intermediates. The synthesized compounds were confirmed by their IR, NMR and Mass spectral data.

APA, Harvard, Vancouver, ISO, and other styles

35

Kim, Youngsam, Sandip V. Mulay, Minsuk Choi, Seungyoon B. Yu, Sangyong Jon, and David G. Churchill. "Exceptional time response, stability and selectivity in doubly-activated phenyl selenium-based glutathione-selective platform." Chemical Science 6, no. 10 (2015): 5435–39. http://dx.doi.org/10.1039/c5sc02090e.

Full text

Abstract:

Outstanding glutathione chemosensing selectivity with a new coumarin-based probe is reported and discussed in the context of live cell experiments; the point of attack is flanked by two proximal carbonyl groups.

APA, Harvard, Vancouver, ISO, and other styles

36

Asbara, P. K. "Synthesis, In Silico, and In Vitro Evaluation of a Coumarin-Based Schiff Base as a Potential Anti-Alzheimer's Agent." International Journal of Pharmacy and Biological Sciences (IJPBS) 14, no. 4 (2024): 101–18. https://doi.org/10.5281/zenodo.14746407.

Full text

Abstract:

AbstractThis study investigates the anti-Alzheimer’s potential of coumarin-based Schiff bases. Among the series of synthesized compounds, the phenyl hydrazine derivative of 3-Acetyl coumarin (PHC) was selected based on its high docking score. Given the limited treatment options for Alzheimer’s disease (AD), this research aims to explore novel therapeutic approaches using coumarin derivatives. In silico studies demonstrated strong binding interactions of PHC with acetylcholinesterase (AChE), with a binding affinity of -10.7 kcal/mol, supporting its role as a multi-target directed li

APA, Harvard, Vancouver, ISO, and other styles

37

Zhang, Hui, Haifang Chai, Tianzhi Yu, Yuling Zhao, and Duowang Fan. "High-Efficiency Blue Electroluminescence Based on Coumarin Derivative 3-(4-(anthracen-10-yl)phenyl)-benzo[5,6]coumarin." Journal of Fluorescence 22, no. 6 (2012): 1509–12. http://dx.doi.org/10.1007/s10895-012-1088-3.

Full text

APA, Harvard, Vancouver, ISO, and other styles

38

Sati, Bhawana, Alka Tyagi, and Anurag. "Newer Coumarin-linked Heterocyclic Hybrids: Design, Synthesis and Biological Assessment as Possible Anti-Alzheimer Drugs." Asian Journal of Chemistry 37, no. 3 (2025): 552–60. https://doi.org/10.14233/ajchem.2025.33211.

Full text

Abstract:

As newer acetyl cholinesterase antagonists which could be effective in Alzheimer’s disease management, derivatives of 4-hydroxycoumarin were prepared. The 2-((2-oxo-2H-chromen-4-yl)oxy)-N-(pyridin-3-yl)acetamide derivative (4c) and 2-((2-oxo-2H-chromen-4-yl)oxy)-N-(pyridin-4-yl)acetamide (4d) showed the maximum AChE inhibition effect (IC50 = 0.957 ± 0.014 and 1.377 ± 0.018 mM, respectively) among the 16 coumarin-derived compounds evaluated against human acetylcholinesterase (hAChE). PHE 338 and HID 447 are responsible for ligand identification and trafficking by creating a polar π-π interactio

APA, Harvard, Vancouver, ISO, and other styles

39

Peddaboina, Usha Rani, ANITHA SADHULA, and Ravinder Nath Anisetti. "Coumarin Imidazolone Hybrid as Inhibitor of Topoisomerase Type II and Hsp90 and as Potent Antimicrobials." Asian Journal of Chemistry 35, no. 11 (2023): 2689–702. http://dx.doi.org/10.14233/ajchem.2023.28004.

Full text

Abstract:

In present study, coumarin imidazolone hybrids were synthesized on the basis of the molecular docking analysis of the compounds (11a-h) by using PyRx 0.8 software. The molecules docking studies were performed against the targets Hsp90 and human type IIA DNA topoisomerase and compared the same with standard drugs fluconazole and doxorubicin. Among all the compounds 11d (-12.7 kcal/mol) and 11f (-12.4 kcal/mol) showed good binding affinity towards human Hsp90 and 11d (-11.5 kcal/mol) and 11e (-11.4 kcal/mol) showed good binding affinity against human type IIA DNA topoisomerase. Based on the posi

APA, Harvard, Vancouver, ISO, and other styles

40

Kudale, Sayali D., and Meenakshi N. Deodhar. "Synthesis and Evaluation of Some Coumarin Containing Potential Antimicrobial Agents." E-Journal of Chemistry 9, no. 4 (2012): 2493–500. http://dx.doi.org/10.1155/2012/953564.

Full text

Abstract:

A series of the Schiff’s bases incorporating coumarin and chalcone moeities, 3-(4-(4-(substituted phenyl)prop-1-ene-3-one) phenylimino) methyl)-4-chloro-2h-chromen-2-one 4(a-g) were synthesized as potential antimicrobial agents. These compounds were characterized on the basis of their spectral (IR,1H NMR) data and evaluated for antimicrobial activity in vitro against gram positive and gram negative bacteria and fungi. Compound 4b was found to be most active with an MIC of 20 µg/mL against all the tested organisms.

APA, Harvard, Vancouver, ISO, and other styles

41

S., S. MADHAVA RAO, and N. TRIVEDI K. "Studies on the Synthesis of Furocoumarins. Part-XXX. A Reinvestigation of Claisen Rearrangement of 7-Cinnamyloxy-4-methylcoumarin." Journal of Indian Chemical Society Vol. 69, Apr 1992 (1992): 203–6. https://doi.org/10.5281/zenodo.6002891.

Full text

Abstract:

Department of Chemistry, Faculty of Science, M. S. University of Baroda, Baroda-390 002 <em>Manuscript received 24 October 1991, accepted 23 March 1992</em> 7-annamylozy. 8-methylcoumarin on Claisen migration gave three products. <em>trans</em>-3, 7-dimethyl 2-phenyl-2 3- dihydrofurel-[2,3-b]Abenzopyran 5[<em>H</em>]-one (la), 7 hydroxy 4-methyl 8-(1'-phenylprop-1'-ene)coumarin (1e) and 7 by drozy 4 methyl 6 (1' phenyiprop 2 -ene)coumariu (if) le and If on cyclisation with H<sub>2</sub>SO<sub>4</sub> gave 2b and 3a respectively 2a 2b and 3a on dehydrogenation with either DDQ in dry

APA, Harvard, Vancouver, ISO, and other styles

42

Tsitrina, Alexandra A., Igor V. Krasylov, Dmitry I. Maltsev, et al. "Inhibition of hyaluronan secretion by novel coumarin compounds and chitin synthesis inhibitors." Glycobiology 31, no. 8 (2021): 959–74. http://dx.doi.org/10.1093/glycob/cwab038.

Full text

Abstract:

Abstract Elevated plasma levels of hyaluronic acid (HA) is a disease marker in liver pathology and other inflammatory disorders. Inhibition of HA synthesis with coumarin 4-methylumbelliferone (4MU) has a beneficial effect in animal models of fibrosis, inflammation, cancer and metabolic syndrome. 4MU is an active compound of approved choleretic drug hymecromone with low bioavailability and a broad spectrum of action. New, more specific and efficient inhibitors of hyaluronan synthases (HAS) are required. We have tested several newly synthesized coumarin compounds and commercial chitin synthesis

APA, Harvard, Vancouver, ISO, and other styles

43

Çamur, Meryem, Ali Rıza Özkaya, and Mustafa Bulut. "Synthesis, characterization and spectroscopic properties of new fluorescent 7,8-dihexyloxy-3-(4-oxyphenyl)coumarin substituted phthalocyanines." Journal of Porphyrins and Phthalocyanines 13, no. 06 (2009): 691–701. http://dx.doi.org/10.1142/s1088424609000905.

Full text

Abstract:

The synthesis of metal-free and metallophthalocyanines ( M = Zn , Co ) obtained from 7,8-dihexyloxy-3-[p-(3',4'-dicyanophenoxy)phenyl]coumarin are described. The newly prepared compounds have been characterized by elemental analysis, IR, NMR, mass and UV-vis spectral data. Their electronic absorption and fluorescence spectral properties are reported. Cyclic voltammetry of the compounds have also been studied. In situ spectroelectrochemistry of the Co(II) complex in THF and DCM is included to identify the difference in its redox behavior, as compared with other complexes.

APA, Harvard, Vancouver, ISO, and other styles

44

Zhang, Caimei, Wenjuan Zhang, Yiran Wu, et al. "Sensitive and Facile HCOOH Fluorescence Sensor Based on Highly Active Ir Complexes’ Catalytic Transfer Hydrogen Reaction." Molecules 27, no. 21 (2022): 7431. http://dx.doi.org/10.3390/molecules27217431.

Full text

Abstract:

With several major polarity and weak optical properties, the sensitive detection of HCOOH remains a major challenge. Given the special role of HCOOH in assisting in the catalytic hydrogenation process of Ir complexes, HCOOH (as a hydrogen source) could rapidly activate Ir complexes as catalysts and further reduce the substrates. This work developed a facile and sensitive HCOOH fluorescence sensor utilizing an optimal catalytic fluorescence generation system, which consists of the phenyl-pyrazole-type Ir-complex PP-Ir-Cl and the coumarin-type fluorescence probe P-coumarin. The sensor demonstrat

APA, Harvard, Vancouver, ISO, and other styles

45

Singh, Dileep Kumar, and Mahendra Nath. "meso-Phenyl-triazole bridged porphyrin-coumarin dyads: Synthesis, characterization and photophysical properties." Dyes and Pigments 121 (October 2015): 256–64. http://dx.doi.org/10.1016/j.dyepig.2015.05.027.

Full text

APA, Harvard, Vancouver, ISO, and other styles

46

Yang, Wenchao, Shuai Yang, Pinhua Li, and Lei Wang. "Visible-light initiated oxidative cyclization of phenyl propiolates with sulfinic acids to coumarin derivatives under metal-free conditions." Chemical Communications 51, no. 35 (2015): 7520–23. http://dx.doi.org/10.1039/c5cc00878f.

Full text

APA, Harvard, Vancouver, ISO, and other styles

47

Thabet, Hamdy Khamees, Mustafa Turki Ubeid, Mohamed Yousef Abu Shuheil, and Mohd Imran. "p-Toluene-sulfonic Acid-catalyzed One-pot, Three-component Synthesis of 4-(4-(Piperidin-1-yl)phenyl)-2-Thioxo-1,2,3,4Tetrahydro-5H-Chromeno[4,3-d]Pyrimidin-5-One." Oriental Journal Of Chemistry 38, no. 2 (2022): 406–9. http://dx.doi.org/10.13005/ojc/380223.

Full text

Abstract:

Here we communicate a method for the synthesis of 4-(4-(piperidin-1-yl)phenyl)-2-thioxo-1,2,3,4-tetrahydro-5H-chromeno[4,3-d]pyrimidin-5-one in one step. The compound was prepared by reacting 4-hydroxy-coumarin, 4-piperidinobenzaldehye, and thiourea in a catalytic quantity of p-toluenesulfonic acid. The novelty of the compound was checked by Sci-finder. The compound was analyzed by NMR spectroscopy (1H, 13C), and mass spectrometry. The computational studies indicate that the synthesized compound possesses suitable physicochemical properties, drug-likeliness features, and good oral bioavailabil

APA, Harvard, Vancouver, ISO, and other styles

48

DWIVEDI, PARMESH K., ASHUTOSH PATHAK, P. MALAIRAJAN, and DEVDUTT CHATURVEDI. "Design, Synthesis and Antimicrobial Evaluations of Novel 3,7-Disubstituted 2H-1-Benzopyran-2-ones." Asian Journal of Chemistry 32, no. 9 (2020): 2397–402. http://dx.doi.org/10.14233/ajchem.2020.22659.

Full text

Abstract:

In present study, a novel class of 3,7-disubstituted 2H-1-benzopyran-2-one derivatives (3xa-3zc) bearing a basic ether side chain at C-7 and a substituted phenyl ring at C-3 of the coumarin ring is synthesized. These compounds have been evaluated for antimicrobial (antibacterial/antifungal) activities. Some of the compounds viz. 3xc, 3xe, 3xf, 3yb, 3yc and 3yf have shown significant antifungal activities against selective strains. Compounds 3xe, 3yb and 3yc with the MIC values of 1.56 μg/mL displayed better antifungal activity than fluconazole against Trichophyton mentagrophytes

APA, Harvard, Vancouver, ISO, and other styles

49

Chinta, Bhargavi, K. Aparna Seetharam, and T. N. V. S. S. Satyade. "Sulphated tin oxide (STO)-catalyzed synthesis of arylated vinyl ethers." Current Chemistry Letters 14, no. 3 (2025): 659–66. https://doi.org/10.5267/j.ccl.2025.2.001.

Full text

Abstract:

The C3 or O-alkylation of 4-hydroxycoumarin (formation of new C-C and C-O bond) is undoubtedly one of the most important and challenging reactions in synthetic chemistry due to its pharmaceutical utility. In this communication, we report sulfated tin oxide (STO)-catalyzed synthesis of arylated vinyl ethers in moderate to good isolated yields (68-93%) from the reaction of substituted phenyl acetylenes (terminal alkynes) with 4-hydroxy coumarin in polyethylene glycol (PEG 400) as solvent at 110 oC. The catalyst can be recycled up to 5 times without losing the significant yield.

APA, Harvard, Vancouver, ISO, and other styles

50

Li, Yan, Shi-Wei Sun, Xiao-Yi Zhang, et al. "Separation of New Coumarin Glycosides from Toddalia asiatica Using Offline Two-Dimensional High-Performance Liquid Chromatography." Plants 9, no. 4 (2020): 428. http://dx.doi.org/10.3390/plants9040428.

Full text

Abstract:

Coumarins and flavonoids are the major constituents of Toddalia asiatica. The separation and purification of ingredients from T. asiatica is an important procedure to acquire high-purity compounds for subsequent pharmacological investigation to discover leading compounds. In the present work, an offline two-dimensional high-performance liquid chromatography (HPLC) method was successfully established for the separation of high-purity glycosides from T. asiatica. Based on the separation results obtained with two different chromatographic stationary phases, a phenyl-bonded silica-based reversed-p

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!