Relevant bibliographies by topics / Phenyl Tetralones

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Academic literature on the topic 'Phenyl Tetralones'

Author: Grafiati
Published: 3 June 2025
Last updated: 31 July 2025

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Journal articles on the topic "Phenyl Tetralones"

1

Yao, Xudong, and Ralph M. Pollack. "Electronic effects on enol acidity and keto-enol equilibrium constants for ring-substituted 2-tetralones." Canadian Journal of Chemistry 77, no. 5-6 (1999): 634–38. http://dx.doi.org/10.1139/v99-006.

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Equilibrium constants for the ionization of a variety of phenyl-substituted 2-tetralones (pKaK), for the ionization of their enols (pKaE), and for keto-enol tautomerization (pKE) were determined. Hammett plots of pKaK and pKaE vs. σ- are linear with slopes (-ρ) of -1.66 ± 0.06 and -0.90 ± 0.03, respectively, except for deviations of the points corresponding to 6-nitro-2-tetralone (1b) and its enol. We have previously attributed the negative deviation of 1b from the correlation for the acidities of the ketones obtained with the more limited set of data to the lack of a free electron pair on C-1
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2

Chaitramallu, M1 Devaraju Kesagodu1 Dakshayini Chandrashekarachar2. "SYNTHESIS AND BIOLOGICAL SCREENING OF ANALOGS OF ARYL TETRALONE." INDO AMERICAN JOURNAL OF PHARMACEUTICAL RESEARCH 07, no. 01 (2017): 7392–98. https://doi.org/10.5281/zenodo.1006777.

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The aryl tetralone as potential antimitotic agents were synthesized in four step reactions using Grignard reagent. The first step is the synthesis of trimethoxy phenyl naphthol (2a-f) by the reaction of substituted tetralone with 3, 4, 5-trimethoxy 1-bromobenzene in magnesium metal using tetrahydrofuran as a solvent. The resulted phenyl naphthol was hydrogenated to give phenyl tetralin 3(a-f). The substituted phenyl tetralone were prepared by the oxidation of trimethoxy phenyl tetralin 4(a-f). The structures of the synthesized compounds were confirmed by spectral and elemental analysis data. T
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3

Amakali, Klaudia, Lesetja Legoabe, Anél Petzer, and Jacobus Petzer. "Synthesis and in vitro Evaluation of 2-heteroarylidene-1-tetralone Derivatives as Monoamine Oxidase Inhibitors." Drug Research 68, no. 12 (2018): 687–95. http://dx.doi.org/10.1055/a-0620-8309.

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AbstractThe present study investigates the human monoamine oxidase (MAO) inhibition properties of a series of twelve 2-heteroarylidene-1-tetralone derivatives. Also included are related cyclohexylmethylidene, cyclopentylmethylidene and benzylidene substituted 1-tetralones. These compounds are related to the 2-benzylidene-1-indanone class of compounds which has previously been shown to inhibit the MAOs, with specificity for the MAO-B isoform. The target compounds were synthesised by the Claisen-Schmidt condensation between 7-methoxy-1-tetralone or 1-tetralone, and various aldehydes, under acid
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4

Yao, Xudong, Mark A. Gold, and Ralph M. Pollack. "Transition State Imbalance in Proton Transfer from Phenyl Ring-Substituted 2-Tetralones to Acetate Ion." Journal of the American Chemical Society 121, no. 26 (1999): 6220–25. http://dx.doi.org/10.1021/ja990070+.

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5

Koltunov, Konstantin Yu. "Condensation of naphthalenediols with benzene in the presence of aluminum bromide: an efficient synthesis of 5-, 6-, and 7-hydroxy-4-phenyl-1- and 2-tetralones." Tetrahedron Letters 49, no. 24 (2008): 3891–94. http://dx.doi.org/10.1016/j.tetlet.2008.04.062.

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6

Wang, Daniel Zerong, Yeong-Joon Kim та Andrew Streitwieser. "Aggregation and Alkylation of Enolates of 2-Phenyl-α-tetralone and 2,6-Diphenyl-α-tetralone1". Journal of the American Chemical Society 122, № 44 (2000): 10754–60. http://dx.doi.org/10.1021/ja0010002.

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7

Curley, Regina K., Andrew W. Macfarlane, and Clodagh M. King. "Contact dermatitis to 2, phenyl tetralone tosylhydrazone." Contact Dermatitis 14, no. 4 (1986): 257–58. http://dx.doi.org/10.1111/j.1600-0536.1986.tb01245.x.

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8

Oliveira, Adriano Bof de, Bárbara Regina Santos Feitosa, Christian Näther, and Inke Jess. "N-Phenyl-2-(1,2,3,4-tetrahydronaphthalen-1-ylidene)hydrazinecarbothioamide." Acta Crystallographica Section E Structure Reports Online 70, no. 2 (2014): o205. http://dx.doi.org/10.1107/s1600536814001585.

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The conformation of the title molecule, C17H17N3S, is stabilized by an intramolecular N—H...N hydrogen bond involving the azometinic group. The dihedral angle between the two aromatic rings is 36.49 (06)°. The non-aromatic ring of the tetralone substituent adopts a sofa conformation. In the crystal, molecules are linked by pairs of N—H...S hydrogen bonds relatedviacentres of symmetry, forming dimers.
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9

F., G. BADDAR, N. BASYOUNI M., F. EI-NEWAIRY M. та H. GHALY E. "ᵧ.ᵧ-Disubstituted Itaconic Acids. Part Vll.1 The Stobbe Condensation of Benzyl-, p-Chlorobenzyl-, and p-Methoxybenzylphenyl Ketones with Diethyl Succinate". Journal of Indian Chemical Society Vol. 51, Jul 1974 (2022): 698–704. https://doi.org/10.5281/zenodo.6417065.

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Department of <em>Chemistry, </em>Faculty of Science, A&#39; in Shams <em>University, Cairo, Egypt.</em> <em>Manuscript received 22 October 1973 ; acepted 23 May 1974.</em> <em>\(Cis \)</em>(Ph/Ar)-5-Aryl-3-ethoxycarbonyl-4-phenyl-pent-4-enoic acids were converted into ethyl <em>\(trans\)-</em>(Ph/Ar)<em><sup>-</sup> 5-aryl-3-</em>carboxy-4-phenyl-pent-4-enoute (14), (15) and (16), which have been cyclised<em> </em>to 1-acetoxy-naphthalenes (17), (18) <em>and </em>(19). <em>\(Cis\) </em>(Ph/ Ar)<em>-4, </em>5-Diphenyl- <em>and </em>cis (Ph/Ar)-4-phenyl-5-p-tolyl-pent-4-enoic acid anhydrides<em
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10

Hauer, Bernhard, Jamie F. Bickley, Julien Massue, Paula CA Pena, Stanley M. Roberts, and John Skidmore. "Biomimetic reactions in organic synthesis: Semi-pinacol rearrangements of some spirocyclic epoxyalcohols derived from Juliá-Colonna asymmetric epoxidations." Canadian Journal of Chemistry 80, no. 6 (2002): 546–50. http://dx.doi.org/10.1139/v02-061.

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Epoxy tert-alcohols have been prepared from (E)-enones in a two-step approach consisting of Juliá–Colonna asymmetric epoxidation followed by Grignard alkylation of the epoxyketone. On treatment with sub-stoichiometric amounts of Yb(OTf)3 these trans-epoxyalcohols underwent efficient stereoselective semi-pinacol rearrangement to afford anti-α-phenyl-β-hydroxy-ketones (aldols). Under the same conditions, spirocyclic epoxyalcohols derived from 1-tetralone and 1-benzosuberone undergo either ring contraction (via semi-pinacol rearrangement) or fragmentation. A mechanistic rationale is presented to
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Conference papers on the topic "Phenyl Tetralones"

1

Lazić, Anita, Ivana Đorđević, Kristina Gak Simić та ін. "Correlation of structure and potential pharmacological activity of spirohidantoins derived from α-Tetralone". У 37th International Congress on Process Industry. SMEITS, 2024. http://dx.doi.org/10.24094/ptk.024.279.

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Hydantoin is a nonaromatic five-membered heterocycle, which is considered a valuable, privileged scaffold in medicinal chemistry. The importance of the hydantoin scaffold in drug dis-covery has been reinforced by several medicines in clinical use, such as anticonvulsants (phenyto-in), antibiotics (nitrofurantoin), anticancer drugs (enzalutamide) and keratolytics (allantoin). To design new potentially pharmacologically active compounds, six spirohydantoin derivatives were synthetized and fully characterized by determination of the melting points, elemental analysis, FT-IR, 1H and 13C NMR spectr
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