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Relevant bibliographies by topics / Phenylpyrido[4,3-d]pyrimidin-2-amine derivatives

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Academic literature on the topic 'Phenylpyrido[4,3-d]pyrimidin-2-amine derivatives'

Author: Grafiati

Published: 28 May 2022

Last updated: 31 July 2025

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Journal articles on the topic "Phenylpyrido[4,3-d]pyrimidin-2-amine derivatives"

1

CHAITANYA, G. DAVE, R. SHAH P., S. PANDYA P., and K. SHAH G. "Pyridopyrimidines. Part-VII. Synthesis and Antibacterial Activity of 4-lminopyrido[2, 3 - d] pyrimidin- 2( 1 H)-thiones, 2-Thioxopyrido[2, 3 - d]pyrimidin-4(3H)-ones and related Compounds." Journal of Indian Chemical Society Vol. 66, Nov 1989 (1989): 810–12. https://doi.org/10.5281/zenodo.6106035.

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Department of Chemistry, St. Xavier's College, Navarangpura, Ahmedabad-380 009 <em>Manuscript received 27 December 1988, revised 23 June 1989, accepted 26 June 1989</em> 2-Amino-3-cyano-4-(4-chlorophenyl)-6-phenylpyridine (I) and 2-amino·3·carboxamido-4-(4-chlorophenyl)·6-phenylpyridine (3) when reacted with various isothiocyanates, 4-amino-3·substituted-5-(4·chlorophenyl)-7·phenylpyrido[2,3-<em>d</em>]pyrimidin-2(1<em>H</em>)-thiones(2) and 2·thioxo-3-substituted-5-(4-chlorophenyl)-7-phenylpyrido[2,3-<em>d</em>]pyrimidin-4(3<em>H</em>)-ones

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2

Zong, Chaoyang, Huiwen Gu, Lijie Zhang, Yudong Jin, and Yaquan Sun. "Microwave-Accelerated Dimroth Rearrangement for the Synthesis of Pyrido [2, 3-d]pyrimidin-4-amine Derivatives." Chinese Journal of Organic Chemistry 38, no. 5 (2018): 1165. http://dx.doi.org/10.6023/cjoc201711028.

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3

Gong, Tang, Liu та Liu. "Synthesis and Evaluation of Novel 2H-Benzo[e]-[1,2,4]thiadiazine 1,1-Dioxide Derivatives as PI3Kδ Inhibitors". Molecules 24, № 23 (2019): 4299. http://dx.doi.org/10.3390/molecules24234299.

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In previous work, we applied the rotation-limiting strategy and introduced a substituent at the 3-position of the pyrazolo [3,4-d]pyrimidin-4-amine as the affinity element to interact with the deeper hydrophobic pocket, discovered a series of novel quinazolinones as potent PI3Kδ inhibitors. Among them, the indole derivative 3 is one of the most selective PI3Kδ inhibitors and the 3,4-dimethoxyphenyl derivative 4 is a potent and selective dual PI3Kδ/γ inhibitor. In this study, we replaced the carbonyl group in the quinazolinone core with a sulfonyl group, designed a series of novel 2H-benzo[e][1

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4

Mohamed, Hany M., and Ashraf H. F. Abd El-Wahab. "Heteroaromatization with 4-Phenyldiazenyl-1-naphthol. Part IV: Synthesis of Some New Heterocyclic Compounds with Potential Biological Activity." Current Organic Synthesis 16, no. 6 (2019): 931–38. http://dx.doi.org/10.2174/1570179416666190719101727.

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Background: Synthetic azo compounds and their derivatives have been studied extensively due to their biological and pharmacological activities. Pyranopyridines, pyranopyrimidines and tetrazoles derivatives have emerged as a promising and attractive scaffold in the development of potent biological and pharmacological agents. Objectives: To design a series of new benzochromeno(pyridine/pyrimidine/tetrazole) derivatives and evaluate their antimicrobial activity against some bacterial strains (Gram-positive and Gram-negative) and some fungal strains. Materials and Methods: The (E)-7-(4-chloropheny

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5

Abdel Aziz, Yasmine M., Mohamed M. Said, Hosam A. El Shihawy, and Khaled A. M. Abouzid. "Discovery of novel tricyclic pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-4-amine derivatives as VEGFR-2 inhibitors." Bioorganic Chemistry 60 (June 2015): 1–12. http://dx.doi.org/10.1016/j.bioorg.2015.03.004.

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6

Solomyannyi, Roman, Sergii Slivchuk, Donald Smee, et al. "In vitro Activity of the Novel Pyrimidines and Their Condensed Derivatives Against Poliovirus." Current Bioactive Compounds 15, no. 5 (2019): 582–91. http://dx.doi.org/10.2174/1573407214666180720120509.

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Background: Substituted pyrimidine derivatives (non-nucleoside) are found to be associated with various biological activities. The various substituted pyrimidines are also having significant in vitro activity against different DNA and RNA viruses. The present study focuses on the anti-PV activity of new pyrimidines and their condensed derivatives. Methods: A series of novel pyrimidines and their condensed derivatives were synthesized and their structures were confirmed by spectral data. Their antiviral activities against poliovirus type 3 (PV-3) were evaluated in vitro. In cell culture, morpho

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7

Bandaru, Praveen Kumar, Satya Kameswara Rao N, and Shyamala P. "Amide Functionalized Novel Pyrrolo-pyrimidine Derivative as Anticancer Agents: Synthesis, Characterization and Molecular Docking Studies." Anti-Cancer Agents in Medicinal Chemistry 25 (November 6, 2024). http://dx.doi.org/10.2174/0118715206333935241004070350.

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Background: The development of new therapies targeting crucial kinases involved in cancer progression is a promising area of research. Pyrazolo pyrimidine derivatives have emerged as potential candidates for this purpose. Objective: This study aims to synthesize pyrazolo pyrimidine derivatives (5a-5r), evaluate their molecular docking against key kinases, and assess their anticancer activity. Methods: The synthesis involved a multi-step procedure starting with the cyclization of 6-amino-2- methylpyrimidin-4(3H)-one (1) to form 2-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-4-ol (2). This was

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8

Shablykin, Oleh V., Volodymyr S. Brovarets, and Olga V. Shablykina. "Recyclization of 5‐Amino‐ oxazoles as a Route to new Functionalized Heterocycles (Developments of V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine)." Chemical Record, October 26, 2023. http://dx.doi.org/10.1002/tcr.202300264.

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AbstractThe recyclizations of 5‐amino‐ and 5‐hydrazine‐1,3‐oxazoles mainly with electron‐withdrawing group in 4th position are considered. The chemical behavior of these heterocycles is due to the presence of two hidden amide fragments; therefore, the recyclization processes include a stage of nucleophile attack on 2nd or 5th position of the oxazole cycle. When the nitrile group is present in 4th position, it is often involved in the recyclization forming α‐aminoazoles. 5‐Amino/hydrazine‐1,3‐oxazoles undergo recyclization both in nucleophilic (amines, hydrazine, thionating agents) and electrop

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