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Journal articles on the topic 'Phloroglucinol compound'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Bare, Yohanes. "Interaction Phloroglucinol as inflammation therapy through Cyclooxygenase-2 (COX-2) gene inhibition." Jurnal Ilmiah Medicamento 8, no. 1 (2022): 14–21. http://dx.doi.org/10.36733/medicamento.v8i1.3162.

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Exploration of natural compounds is one of the projects in the context of curving disease, one of which is inflammatory therapy in the body, one of the natural ingredients used is Phloroglucinol which has anti-inflammatory properties but there is no information on molecular studies related to its activity. The purpose of this study was to explore the potential of Phloroglucinol as an anti-inflammatory mechanism. Phloroglucinol compound (CID 359) was downloaded from the PubChem Protein COX-2 database (PDB ID 6cox) downloaded from the Protein Data Bank database. The compound Phloroglucinol inter

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2

Catarino, Marcelo D., Beatriz S. Baía Costa, Ana Rita Circuncisão, Artur M. S. Silva, Susana M. Cardoso та Susana Santos Braga. "γ-Cyclodextrin Inclusion of Phloroglucinol: Solid State Studies and Antioxidant Activity throughout the Digestive Tract". Applied Sciences 12, № 5 (2022): 2340. http://dx.doi.org/10.3390/app12052340.

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Phloroglucinol is a powerful antioxidant compound and an active pharmaceutical ingredient used in the management of intestinal spasms. In this report, we describe the interaction of γ-cyclodextrin with phloroglucinol to readily form a solid inclusion compound with 1:1 by co-dissolution and freeze-drying. Solid-state characterisation using FT-IR, thermal analyses (TGA and DTA) and X-ray powder diffraction confirmed the formation of a true inclusion compound (γ-CD·PG) in which the molecules of γ-CD are stacked into channels. This spatial arrangement is typical of γ-CD inclusion compounds, and it

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3

Teng, Xingxing, Yuanyuan Wang, Jinhua Gu, Peiqi Shi, Zhibin Shen, and Lianbao Ye. "Antifungal Agents: Design, Synthesis, Antifungal Activity and Molecular Docking of Phloroglucinol Derivatives." Molecules 23, no. 12 (2018): 3116. http://dx.doi.org/10.3390/molecules23123116.

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Pseudoaspidinol is a phloroglucinol derivative with Antifungal activity and is a major active component of Dryopteris fragrans. In our previous work, we studied the total synthesis of pseudoaspidinol belonging to a phloroglucinol derivative and investigated its antifungal activity as well as its intermediates. However, the results showed these compounds have low antifungal activity. In this study, in order to increase antifungal activities of phloroglucinol derivatives, we introduced antifungal pharmacophore allylamine into the methylphloroglucinol. Meanwhile, we remained C1–C4 acyl group in C

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4

Park, Cheol, Hee-Jae Cha, Hyun Hwangbo, et al. "Phloroglucinol Inhibits Oxidative-Stress-Induced Cytotoxicity in C2C12 Murine Myoblasts through Nrf-2-Mediated Activation of HO-1." International Journal of Molecular Sciences 24, no. 5 (2023): 4637. http://dx.doi.org/10.3390/ijms24054637.

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Phloroglucinol is a class of polyphenolic compounds containing aromatic phenyl rings and is known to have various pharmacological activities. Recently, we reported that this compound isolated from Ecklonia cava, a brown alga belonging to the family Laminariaceae, has potent antioxidant activity in human dermal keratinocytes. In this study, we evaluated whether phloroglucinol could protect against hydrogen peroxide (H2O2)-induced oxidative damage in murine-derived C2C12 myoblasts. Our results revealed that phloroglucinol suppressed H2O2-induced cytotoxicity and DNA damage while blocking the pro

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5

Li, Ning, Shabana Khan, Shi Qiu, and Xing-Cong Li. "Synthesis and Anti-Inflammatory Activities of Phloroglucinol-Based Derivatives." Molecules 23, no. 12 (2018): 3232. http://dx.doi.org/10.3390/molecules23123232.

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The natural product phloroglucinol-based derivatives representing monoacyl-, diacyl-, dimeric acyl-, alkylated monoacyl-, and the nitrogen-containing alkylated monoacylphloro- glucinols were synthesized and evaluated for inhibitory activities against the inflammatory mediators such as inducible nitric oxide synthase (iNOS) and nuclear factor kappaB (NF-κB). The diacylphloroglucinol compound 2 and the alkylated acylphloroglucinol compound 4 inhibited iNOS with IC50 values of 19.0 and 19.5 µM, respectively, and NF-κB with IC50 values of 34.0 and 37.5 µM, respectively. These compounds may serve a

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6

Paumann-Page, Martina, Christian Obinger, Christine C. Winterbourn, and Paul G. Furtmüller. "Peroxidasin Inhibition by Phloroglucinol and Other Peroxidase Inhibitors." Antioxidants 13, no. 1 (2023): 23. http://dx.doi.org/10.3390/antiox13010023.

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Human peroxidasin (PXDN) is a ubiquitous peroxidase enzyme expressed in most tissues in the body. PXDN represents an interesting therapeutic target for inhibition, as it plays a role in numerous pathologies, including cardiovascular disease, cancer and fibrosis. Like other peroxidases, PXDN generates hypohalous acids and free radical species, thereby facilitating oxidative modifications of numerous biomolecules. We have studied the inhibition of PXDN halogenation and peroxidase activity by phloroglucinol and 14 other peroxidase inhibitors. Although a number of compounds on their own potently i

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7

Alexanyan, Karina G., Olga A. Stokolos, Samir Yu Salmanov, et al. "SYNTHESIS AND STUDY OF PROPERTIES OF DERIVATIVES OF PHLOROGLUCINOLMETHYLVIOLOGEN AS ANTIOXIDANT ADDITIVES TO OILS." IZVESTIYA VYSSHIKH UCHEBNYKH ZAVEDENII KHIMIYA KHIMICHESKAYA TEKHNOLOGIYA 62, no. 8 (2019): 132–38. http://dx.doi.org/10.6060/ivkkt.20196208.5993.

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At the present time there is a need to search for new organic compounds with pronounced antioxidant activity. In this work, we studied indicators of antioxidant stability of the compounds obtained by the modification of the phloroglucinol and methylviologen, and identified the basic principles of the synthesis of antioxidant additives. Moreover, the synthesized compounds can act as metal deactivator. These deactivators are phenolic compounds containing functional groups, for example, the iminogroup, which lead to the deactivation of the metal ion through the formation of stable complexes. A li

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8

Park, Cheol, Hee-Jae Cha, Min Yeong Kim, et al. "Phloroglucinol Attenuates DNA Damage and Apoptosis Induced by Oxidative Stress in Human Retinal Pigment Epithelium ARPE-19 Cells by Blocking the Production of Mitochondrial ROS." Antioxidants 11, no. 12 (2022): 2353. http://dx.doi.org/10.3390/antiox11122353.

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Phloroglucinol, a phenolic compound, is known to possess a potent antioxidant ability. However, its role in retinal cells susceptible to oxidative stress has not been well elucidated yet. Thus, the objective of this study was to evaluate whether phloroglucinol could protect against oxidative damage in cultured human retinal pigment epithelium ARPE-19 cells. For this purpose, ARPE-19 cells were stimula ted with hydrogen peroxide (H2O2) to mimic oxidative stress. Cell viability, cytotoxicity, apoptosis, reactive oxygen species (ROS) generation, mitochondrial function, DNA damage, and autophagy w

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9

Abdulrashid, Nasirudeen Idowu, Suleiman Aminu, Rahma Muhammad Adamu, et al. "Phloroglucinol as a Potential Candidate against Trypanosoma congolense Infection: Insights from In Vivo, In Vitro, Molecular Docking and Molecular Dynamic Simulation Analyses." Molecules 27, no. 2 (2022): 469. http://dx.doi.org/10.3390/molecules27020469.

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Sub-Saharan Africa is profoundly challenged with African Animal Trypanosomiasis and the available trypanocides are faced with drawbacks, necessitating the search for novel agents. Herein, the chemotherapeutic potential of phloroglucinol on T. congolense infection and its inhibitory effects on the partially purified T. congolense sialidase and phospholipase A2 (PLA2) were investigated. Treatment with phloroglucinol for 14 days significantly (p < 0.05) suppressed T. congolense proliferation, increased animal survival and ameliorated anemia induced by the parasite. Using biochemical and histop

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10

Kurnia, Dikdik, Dadan Sumiarsa, Hendra D. A. Dharsono, and Mieke H. Satari. "Bioactive Compounds Isolated from Indonesian Epiphytic Plant of Sarang Semut and Their Antibacterial Activity against Pathogenic Oral Bacteria." Natural Product Communications 12, no. 8 (2017): 1934578X1701200. http://dx.doi.org/10.1177/1934578x1701200814.

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A new phenolic compound (1), a steroid (2), a new steroid glycoside (4), two triterpenoids (3 & 6) and a new phloroglucinol-sesquiterpene (5) have been isolated from the ethyl acetate extract of Sarang Semut ( Myrmecodia pendans) and their structures were determined on the basis of the spectral data. The bioactivity evaluation was conducted with the inhibition zone of compounds (mm) using Kirby-Bauer method at concentrations of 1000 and 5000 ppm for compound 1 against pathogenic oral bacteria Enterococcus faecalis, was 8.55 and 8.05 mm, respectively. Compounds 2–3 against Streptococcus mut

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11

Nguyen, Anh Van, Anh Thi Ngoc Vu, Liya V. Bazan, et al. "Synthesis, characterization, and sorption activity of novel azo-colorants derived from phloroglucinol and antipyrine and their metal complexes." RSC Advances 12, no. 2 (2022): 888–98. http://dx.doi.org/10.1039/d1ra07254d.

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Two novel azo-colorants derived from phloroglucinol and antipyrine, and 10 metal complexes were studied. Both the ligands and their metal complexes show coloristic activity, while the H3L2 compound possesses good sorption activity.

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12

Kiehlmann, E., and R. W. Lauener. "Bromophloroglucinols and their methyl ethers." Canadian Journal of Chemistry 67, no. 2 (1989): 335–44. http://dx.doi.org/10.1139/v89-055.

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All 16 bromination products of phloroglucinol and its methyl ethers, as well as five bromoresorcinols and three of their dimethyl ethers, were synthesized and analyzed by nuclear magnetic resonance spectroscopy. Two or three equivalents of bromine convert phloroglucinol to di- and tribromophloroglucinol, 5-methoxyresorcinol to the tri- and 2,4-dibromo, 3,5-dimethoxyphenol to the tri- and 2,6-dibromo, and 1,3,5-trimethoxybenzene to the dibromo compound. With one equivalent of bromine, 3,5-dimethoxyphenol reacts preferentially at C-2 while 5-methoxyresorcinol gives both monobromo isomers. Partia

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13

Touafek, Ouassila, Zahia Kabouche, Joël Boustie, and Christian Bruneau. "A New Long-Chain Unsaturated Ester and Other Constituents of Hypericum tomentosum." Natural Product Communications 7, no. 1 (2012): 1934578X1200700. http://dx.doi.org/10.1177/1934578x1200700123.

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Three long-chain unsaturated esters (1-3), a fatty acid (4), a fatty ester (5), phytone (6) and a phloroglucinol (hyperfoliatin) (7) were isolated from the light petroleum extract of the endemic species Hypericum tomentosum L. (Clusiaceae). Compound 2, 8,10,13-trimethyltetradecanoic acid (2E)-3-methylhexadec-2-enyl ester, which we named tomentosate, is reported for the first time. The structures of the identified compounds were established on the basis of physical and spectroscopic analysis, and by comparison with literature data.

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14

Honda, Ichiro, Makoto Sibagaki, Koichi Yoneyama, et al. "Photosystem II Inhibition by Phloroglucinol Derivatives Having Both Phenol and Urea Functionalities." Zeitschrift für Naturforschung C 48, no. 3-4 (1993): 159–62. http://dx.doi.org/10.1515/znc-1993-3-408.

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Abstract Esters of 3-nitrophloroglucinecarboxylic acid were found to be active photosystem II (PS II) inhibitors, as were the amides, indicating that, in their structures, the substituted phloroglucinol nuclei themselves plays a major roles in PS II inhibition. Among the phenylureidoalkyl esters tested, 3,4-dichlorophenylurea compound having two amino hydrogen atoms showed high activities. Optimal activity was associated with compounds in which the oxygen atom and the urea structure in the ester side chain were connected via an ethylene group.

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15

Ma, Yonghui, Xiaoyu Liu, Bo Liu, et al. "Hyperacmosin R, a New Decarbonyl Prenylphloroglucinol with Unusual Spiroketal Subunit from Hypericum acmosepalum." Molecules 27, no. 18 (2022): 5932. http://dx.doi.org/10.3390/molecules27185932.

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Two previously undescribed polycyclic polyprenylated acylphloroglucinols, hyperacmosins R-S (1–2), were obtained from the aerial parts of Hypericum acmosepalum. Their structures were elucidated by extensive spectroscopic analysis and electronic circular dichroism calculation (ECD). Compound 1 featured an unprecedented 5,8-spiroketal subunit as well as the loss of C-2′ carbonyl in the phloroglucinol ring. In addition, compounds 1 and 4 showed weak hepatoprotective activity against paracetamol-induced HepG2 cell damage at 10 μm. The plausible biosynthetic pathway of 1 was proposed via a retro-Cl

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16

Yang, Zuomiao, Xueting Li, Meiqi Yu, Shan Jiang, and Hang Qi. "Effects of Different Processing Methods on the Quality and Physicochemical Characteristics of Laminaria japonica." Foods 12, no. 8 (2023): 1619. http://dx.doi.org/10.3390/foods12081619.

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The effects of four domestic cooking methods, including blanching, steaming, boiling, and baking treatments, on processing properties, bioactive compound, pigments, flavor components, and tissue structure of Laminaria japonica were investigated. The results showed that the color and structure of kelp changed most obviously after baking; steaming was most beneficial in reducing the color change of the kelp (ΔE < 1), while boiling was most effective in maintaining the texture of the kelp (its hardness and chewiness were close to that of raw kelp); eight volatile compounds were detected in raw

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17

Nuzzo, Assunta, Pierluigi Mazzei, Davide Savy, Vincenzo Di Meo, and Alessandro Piccolo. "Bio-Based Hydrogels Composed of Humic Matter and Pectins of Different Degree of Methyl-Esterification." Molecules 25, no. 12 (2020): 2936. http://dx.doi.org/10.3390/molecules25122936.

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We prepared humo-pectic hydrogels through ionotropic gelation by crosslinking natural pectins of different degree of methyl-esterification with either humic substances (HS) extracted from cow manure compost or humic-like substances (HULIS) from depolymerized lignocellulose biorefinery waste. The hydrogels were characterized by solid-state 13C-NMR spectroscopy, scanning electron microscopy, spectroscopic magnetic resonance imaging and rheological analyses. Their ability to work as controlled release systems was tested by following the release kinetics of a previously incorporated model phenolic

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18

Murata, Naoki, Saki Keitoku, Hideo Miyake, Reiji Tanaka, and Toshiyuki Shibata. "Evaluation on Intestinal Permeability of Phlorotannins Using Caco-2 Cell Monolayers." Natural Product Communications 17, no. 1 (2022): 1934578X2110704. http://dx.doi.org/10.1177/1934578x211070415.

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Among the phlorotannins of seaweed polyphenols, eckols which have a dibenzodioxin linkage are known to have various physiological functions. The purpose of this study was to investigate the intestinal epithelial absorption of eckols using Caco-2 cell monolayers of the small intestinal membrane model. Each compound permeated from the apical (AP) side to the basolateral (BL) side in the monolayers was identified and quantitated by liquid chromatography-mass spectrometry with electrospray ionization. In the transport assays using five types of eckols (eckol, fucofuroeckol A, phlorofucofuroeckol A

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19

Bhausaheb Dhamak, Kiran, Umadevi A, V. Sekar, et al. "Invitro Evaluation of the Anti-Inflammatory Activity of Phloroglucinol and Alpha-lipoic acid." Journal of Neonatal Surgery 14, no. 4S (2025): 1176–83. https://doi.org/10.52783/jns.v14.1928.

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It was decided to test the anti-inflammatory activity of phloroglucinol and alpha-lipoic acid combined in order to evaluate the possibility of a synergistic effect in the battle against inflammation. Both the antioxidant alpha-lipoic acid and the naturally occurring phenolic compound phloroglucinol were investigated by researchers in order to ascertain whether or not they were capable of modulating inflammatory pathways and pathways in vitro. The effects of the combination on numerous inflammatory mediators, including cytokines (TNF-α, IL-1β, and IL-6), prostaglandin E2 (PGE2), and nitric oxid

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Mendes, Vanda, Rita Vilaça, Victor de Freitas, Pedro Moradas Ferreira, Nuno Mateus, and Vítor Costa. "Effect of Myricetin, Pyrogallol, and Phloroglucinol on Yeast Resistance to Oxidative Stress." Oxidative Medicine and Cellular Longevity 2015 (2015): 1–10. http://dx.doi.org/10.1155/2015/782504.

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The health beneficial effects of dietary polyphenols have been attributed to their intrinsic antioxidant activity, which depends on the structure of the compound and number of hydroxyl groups. In this study, the protective effects of pyrogallol, phloroglucinol, and myricetin on the yeastSaccharomyces cerevisiaewere investigated. Pyrogallol and myricetin, which have a pyrogallol structure in the B ring, increased H2O2resistance associated with a reduction in intracellular oxidation and protein carbonylation, whereas phloroglucinol did not exert protective effects. The acquisition of oxidative s

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Tawaha, Khaled, Rasha Sadi, Fadi Qa’dan, Khalid Z. Matalka, and Adolf Nahrstedt. "A Bioactive Prodelphinidin from Mangifera indica Leaf Extract." Zeitschrift für Naturforschung C 65, no. 5-6 (2010): 322–26. http://dx.doi.org/10.1515/znc-2010-5-603.

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A new trimeric proanthocyanidin, epigallocatechin-3-O-gallat-(4β→8)-epigallocatechin- (4β→8)-catechin (1), was isolated together with three known flavan-3-ols, catechin (2), epicatechin (3), and epigallocatechin (4), and three dimeric proanthocyanidins, 5 - 7, from the air-dried leaves of Mangifera indica. Their chemical structures were determined on the basis of 1D- and 2D-NMR spectra (HSQC, HMBC) of their peracetylated derivatives, MALDITOF- mass spectra, and by acid-catalyzed degradation with phloroglucinol. The isolated compounds 1 - 7 were in vitro tested for their inhibitory activities a

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Diego-González, Lara, Milena Álvarez-Viñas, Rosana Simón-Vázquez, Herminia Domínguez, Maria Dolores Torres, and Noelia Flórez-Fernández. "Characterization of the Antiproliferative Activity of Sargassum muticum Low and High Molecular Weight Polysaccharide Fractions." Marine Drugs 22, no. 1 (2023): 16. http://dx.doi.org/10.3390/md22010016.

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The extract obtained by pressurized hot water extraction from Sargassum muticum, to recover the bioactive compound known as fucoidan, was fractionated using membranes of 100, 50, 30, 10, and 5 kDa, obtaining five retentates and the final permeate. These fractions were characterized for phloroglucinol content, protein content, sulfate content, and trolox equivalent antioxidant capacity (TEAC); apart from oligosaccharides, FTIR and molar mass distribution were also evaluated. Retentates of 100 and 50 kDa showed higher values for phloroglucinol, TEAC, and sulfate content. The rheology of the algi

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23

Lim, Chan-Kiang, Subramaniam Hemaroopini, Yee-How Say, and Vivien Yi-Mian Jong. "Cytotoxic Compounds from the Stem Bark of Calophyllum soulattri." Natural Product Communications 12, no. 9 (2017): 1934578X1701200. http://dx.doi.org/10.1177/1934578x1701200922.

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Chemical investigation of the stem bark of Calophyllum soulattri resulted in the isolation of a new phloroglucinol, namely calosubellinone (1) along with two known compounds, garsubellin B (2) and soulattrone A (3). The structures of these compounds were established on the basis of spectroscopic methods. Compounds 1 and 2 displayed growth inhibitory activities against HeLa cancer cells comparable to the positive control cisplatin, with IC50 values of 19.3 and 16.5 μM, respectively. In addition, compound 2 also showed antiproliferative activity against a MDA-MB-231 cancer cell line with an IC50

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24

Kiss, László, Péter Szabó, and Sándor Kunsági-Máté. "Comparison between Electrooxidation of 1-Naphthol and 2-Naphthol in Different Non-Aqueous Solvents and Suppression of Layer Growth of Polymers." Surfaces 7, no. 1 (2024): 164–80. http://dx.doi.org/10.3390/surfaces7010011.

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The two naphthol isomers were investigated in different organic solvents by taking cyclic voltammograms, and fouling took place on a platinum electrode surface, except for dimethyl sulfoxide and dimethyl formamide. Studies in allyl alcohol rarely used in electrochemical investigations pointed to the importance of the carbon–carbon double bond as electrode deactivation was remarkably faster compared with its saturated analog solvent. Similarly, the use of the other unsaturated solvent mesityl oxide in the electropolymerization of naphthols resulted in different findings compared with methyl iso

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Ramana, L. V., M. Suri Appa Rao, K. M. Ch Apparao, and B. Nageswara Rao. "Enantio Selective Synthesis of New Phenylpropanoid: Isolated from Walsura trifoliata." Asian Journal of Chemistry 31, no. 9 (2019): 2042–46. http://dx.doi.org/10.14233/ajchem.2019.22064.

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A new phenylpropanoid containing flavon-3-ol has been isolated from the leaves of traditional medicinal plant, Walsura trifoliata. The structure of the compound was established on the basis of spectroscopic evidence [2D NMR, HREIMS] and by its alternative synthesis. The synthesis of this natural product was achieved from inexpensive and readily available starting materials of phloroglucinol dihydrate. Key reaction sequence includes Grubbs-II RCM reaction, Wittig reaction and sharpless dihydroxylation using AD-mix α.

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Ménard, Raphaël, Claire Negrell-Guirao, Laurent Ferry, Rodolphe Sonnier, and Ghislain David. "Synthesis of biobased phosphate flame retardants." Pure and Applied Chemistry 86, no. 11 (2014): 1637–50. http://dx.doi.org/10.1515/pac-2014-0703.

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Abstract An approach to prepare some biobased flame retardant (FR) compounds is presented. The adopted strategy consists in functionalizing an aromatic biobased phenolic compound, the phloroglucinol, with different phosphate groups in order to promote a charring effect. Different chlorophosphates were grafted onto phloroglucinol hydroxy groups and the functionalization of the hydroxy groups was quantitative. The synthesized biobased FR were incorporated into an epoxy matrix as additive to estimate their flame retardant properties. The influence of different parameters was studied such as the p

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Vothi, Hai, Congtranh Nguyen, Kyunghoon Lee, and Jinhwan Kim. "Thermal stability and flame retardancy of novel phloroglucinol based organo phosphorus compound." Polymer Degradation and Stability 95, no. 6 (2010): 1092–98. http://dx.doi.org/10.1016/j.polymdegradstab.2010.02.024.

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Oziminski, Wojciech P., and Agata Wójtowicz. "New theoretical insights on tautomerism of hyperforin—a prenylated phloroglucinol derivative which may be responsible for St. John’s wort ( Hypericum perforatum ) antidepressant activity." Structural Chemistry 31, no. 2 (2019): 657–66. http://dx.doi.org/10.1007/s11224-019-01434-6.

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AbstractThe thermodynamic aspects of keto-enol tautomerism of hyperforin were investigated theoretically using density functional theory methods. At the B3LYP/aug-cc-pVTZ//B3LYP/aug-cc-pVDZ level of theory the enol tautomer dominates the tautomeric mixture and the second enol tautomer 1OH-HB has Gibbs free energy higher by 1.2 kcal/mol, despite possessing an intramolecular hydrogen bond. The purely keto tautomer is less stable by 3.3 kcal/mol compared with the 1OH tautomer, which means that the percentage of the keto tautomer in the tautomeric mixture is only about 0.4%. This is a different pi

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Murata, Naoki, Mitsuhiro Azuma, Kousuke Yamauchi, Hideo Miyake, Reiji Tanaka та Toshiyuki Shibata. "Phlorotannins Remarkably Suppress the Formation of Nε-(Carboxymethyl)lysine in a Collagen-Glyoxal Environment". Natural Product Communications 15, № 7 (2020): 1934578X2094165. http://dx.doi.org/10.1177/1934578x20941655.

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N ε-(Carboxymethyl)lysine (CML), which is formed by the glycation of collagen, is a skin-accumulating advanced glycation end product and has been shown to be deeply involved in diabetic osteopenia and skin aging. In this study, we prepared the phlorotannins of marine algal polyphenols from Japanese Lessoniaceae ( Ecklonia cava, Ecklonia kurome, cultured E. kurome, Ecklonia stolonifera, Eisenia nipponica, and Eisenia bicyclis) and evaluated their inhibitory activities against CML formation in a collagen-glyoxal environment. The level of CML formed from the glycation of collagen by glyoxal was d

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Sui, Xinyue, Likun Guo, Zixian Bao, Mo Xian, and Guang Zhao. "Efflux Pumps and Porins Enhance Bacterial Tolerance to Phenolic Compounds by Inhibiting Hydroxyl Radical Generation." Microorganisms 13, no. 1 (2025): 202. https://doi.org/10.3390/microorganisms13010202.

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Phenolic compounds are industrially versatile chemicals that have been successfully produced in microbial cell factories. Unfortunately, most phenolic compounds are highly toxic to cells in specific cellular environments or above a particular concentration because they form a complex with iron and promote hydroxyl radical production in Fenton reactions, resulting in the ferroptosis of cells. Here, we demonstrated that overexpression of efflux pumps and porins, including porins LamB and OmpN, and efflux pumps EmrAB, MdtABC, and SrpB, can enhance Escherichia coli phloroglucinol (PG) tolerance by

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Lams, Yusuf Y., P. O. Nkeonye, K. A. Bello, M. K. Yakubu, and A. O. Lawal. "Synthesis of Malononitrile-Condensed Disperse Dyes and Application on Polyester and Nylon Fabrics." Journal of Textiles 2014 (December 8, 2014): 1–8. http://dx.doi.org/10.1155/2014/460794.

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An active methylene compound, malononitrile, was introduced into the structures of a series of disperse dyes previously prepared by coupling phloroglucinol, barbituric acid, and α and β-naphtho to 4-amino-3-nitrobenzaldehyde. The dyes were purified by recrystallization from ethanol. The purity of the dyes was examined by thin-layer chromatography (TLC) and the dyes were characterized by visible absorption and Fourier transform infrared spectroscopy (FTIR). The malononitrile-condensed dyes produced deeper colours and shades with better fastness to wash, light, and perspiration on application to

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Xu, Wenliang, Danxia Shi, Kuanmin Chen, and David G. Popovich. "TLC-Bioautography-Guided Isolation and Assessment of Antibacterial Compounds from Manuka (Leptospermum scoparium) Leaf and Branch Extracts." Molecules 29, no. 3 (2024): 717. http://dx.doi.org/10.3390/molecules29030717.

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A rapid procedure for the targeted isolation of antibacterial compounds from Manuka (Leptospermum scoparium) leaf and branch extracts was described in this paper. Antibacterial compounds from three different Manuka samples collected from New Zealand and China were compared. The active compounds were targeted by TLC-bioautography against S. aureus and were identified by HR-ESI-MS, and -MS/MS analysis in conjunction with Compound Discoverer 3.3. The major antibacterial component, grandiflorone, was identified, along with 20 β-triketones, flavonoids, and phloroglucinol derivatives. To verify the

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Gupta, Payal, Prasanta K. Dash, Tenkabailu Dharmanna Sanjay, Sharat Kumar Pradhan, Rohini Sreevathsa, and Rhitu Rai. "Cloning and Molecular Characterization of the phlD Gene Involved in the Biosynthesis of “Phloroglucinol”, a Compound with Antibiotic Properties from Plant Growth Promoting Bacteria Pseudomonas spp." Antibiotics 12, no. 2 (2023): 260. http://dx.doi.org/10.3390/antibiotics12020260.

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phlD is a novel kind of polyketide synthase involved in the biosynthesis of non-volatile metabolite phloroglucinol by iteratively condensing and cyclizing three molecules of malonyl-CoA as substrate. Phloroglucinol or 2,4-diacetylphloroglucinol (DAPG) is an ecologically important rhizospheric antibiotic produced by pseudomonads; it exhibits broad spectrum anti-bacterial and anti-fungal properties, leading to disease suppression in the rhizosphere. Additionally, DAPG triggers systemic resistance in plants, stimulates root exudation, as well as induces phyto-enhancing activities in other rhizoba

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Rahimmalek, Mehdi, Antoni Szumny, Shima Gharibi, Natalia Pachura, Mehran Miroliaei, and Jacek Łyczko. "Chemical Investigations in Kelussia odoratissima Mozaff. Leaves Based on Comprehensive Analytical Methods: LC-MS, SPME, and GC-MS Analyses." Molecules 28, no. 16 (2023): 6140. http://dx.doi.org/10.3390/molecules28166140.

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Kelussia odoratissima Mozaff. is a species of Apiaceae endemic to the Zagros Mountains in Iran. In the present investigation, for the first time, the polyphenolic compounds and flavonoids of its leaves were determined by liquid chromatography-mass spectrometry (LC-MS). As a result, p-coumaric acid, ferulic acid, caffeic acid, chlorogenic acid, acetyl phloroglucinol, vanillic acid, m-coumaric acid, and 4-methylsiringol were determined as the main phenolic compounds, while 3-hydroxyflavone, flavone, quercetin, rutin, neohesperidin, polydatin, and diosmin were the main flavonoid components, of wh

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Rizzo, Paride, Lothar Altschmied, Beena M. Ravindran, Twan Rutten, and John C. D’Auria. "The Biochemical and Genetic Basis for the Biosynthesis of Bioactive Compounds in Hypericum perforatum L., One of the Largest Medicinal Crops in Europe." Genes 11, no. 10 (2020): 1210. http://dx.doi.org/10.3390/genes11101210.

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Hypericum perforatum L. commonly known as Saint John’s Wort (SJW), is an important medicinal plant that has been used for more than 2000 years. Although H. perforatum produces several bioactive compounds, its importance is mainly linked to two molecules highly relevant for the pharmaceutical industry: the prenylated phloroglucinol hyperforin and the naphtodianthrone hypericin. The first functions as a natural antidepressant while the second is regarded as a powerful anticancer drug and as a useful compound for the treatment of Alzheimer’s disease. While the antidepressant activity of SJW extra

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Janceva, Sarmīte, Aleksandr Arshanica, Līga Lauberte, et al. "Microwave Based Pretreatment for Efficient Extraction of Biologically Active Compounds from Fucus vesiculosus." Key Engineering Materials 850 (June 2020): 190–95. http://dx.doi.org/10.4028/www.scientific.net/kem.850.190.

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Fucus V e s i culosus (F. Vesiculosus ) by its composition is a unique raw for obtaining of variety substances with a wide range of consumer properties. The composition of the polyphenolic fraction of F.Vesiculosus is characterized by a predominant content of phloroglucinol polymers - phlorotannins, which are the target compound of this study. Microwave assisted pre-treatments of algae were carried out in order to intensify the extraction of target compound. The pre-treatment efficiency was evaluated by determining the yield of extractives, polyphenols and phlorotannins. The chemical compositi

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Drygalski, Krzysztof, Katarzyna Siewko, Andrzej Chomentowski, et al. "Phloroglucinol Strengthens the Antioxidant Barrier and Reduces Oxidative/Nitrosative Stress in Nonalcoholic Fatty Liver Disease (NAFLD)." Oxidative Medicine and Cellular Longevity 2021 (January 14, 2021): 1–18. http://dx.doi.org/10.1155/2021/8872702.

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Nonalcoholic fatty liver disease (NAFLD) is one of the most commonly occurring diseases within western dietary patterns. Usually untreated, it may lead to type 2 diabetes mellitus (T2DM), steatohepatitis (NASH), and hepatocellular carcinoma (HCC). Besides its severe aftermath, up to now, there is no known therapeutic approach to this disease in everyday clinical practice. Most NAFLD patients are encouraged to do physical activities or diet change and remain without pharmacological treatment. In this study, we present phloroglucinol (PHG) as a novel and promising compound in NAFLD treatment. PH

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Corfield, Peter W. R., and Amy M. Balija. "Benzene-1,3,5-triyl tribenzoate." Acta Crystallographica Section E Structure Reports Online 69, no. 12 (2013): o1822—o1823. http://dx.doi.org/10.1107/s1600536813031462.

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The title compound, C27H18O6, commonly known as phloroglucinol tribenzoate, is a standard unit for the family of benzyl ether dendrimers. The central phloroglucinol residue is close to planar, with out-of-plane distances for the three oxygen atoms of up to 0.095 (3) Å, while the three attached benzoate groups are approximately planar. One benzoate group is twisted [C—C—O—C torsion angle = 98.2 (3)°] from the central plane, with its carbonyl O atom 2.226 (4) Å above that plane, while the other two benzoate groups are twisted in the opposite direction [C—C—O—C torsion angles = 24.7 (2) and 54.8

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Roy, Sandipan, and Kumar Biradha. "Coordination Polymers of Silver(I) with the Flexible Tritopic Ligand 1,3,5-Tri(4-cyanophenoxy)benzene: Guest Inclusion and Luminescent Properties." Australian Journal of Chemistry 66, no. 4 (2013): 436. http://dx.doi.org/10.1071/ch12476.

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A new flexible tritopic ligand, 1,3,5-tri(4-cyanophenoxy)benzene (1), was synthesised by the reaction of phloroglucinol and para-fluorobenzonitrile. Compound 1 crystallises in the non-centrosymmetric space group Pna21. The reaction of ligand 1 with AgBF4 in the presence of different aromatic guest molecules was found to result in coordination polymers, namely, {[Ag3(1)2(BF4)3(H2O)2]·2C7H8·2CH2Cl2}n (2), {[Ag3(1)2(BF4)3(H2O)2]·2C6H6·2CH2Cl2}n (3). The crystal structures of 2 and 3 reveal that ligand 1 is linked by AgI ions into three-dimensional networks containing channels that are occupied by

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Zhao, Zhe, Xiu-qi Bao, Zihong Zhang, Hui Liu, and Dan Zhang. "Phloroglucinol derivative compound 21 attenuates cuprizone-induced multiple sclerosis mice through promoting remyelination and inhibiting neuroinflammation." Science China Life Sciences 63, no. 6 (2019): 905–14. http://dx.doi.org/10.1007/s11427-019-9821-2.

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Zhao, Zhe, Xiu-qi Bao, Zihong Zhang, Fangyuan Li, Hui Liu, and Dan Zhang. "Novel phloroglucinol derivative Compound 21 protects experimental autoimmune encephalomyelitis rats via inhibiting Th1/Th17 cell infiltration." Brain, Behavior, and Immunity 87 (July 2020): 751–64. http://dx.doi.org/10.1016/j.bbi.2020.03.009.

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Muthu, Sakthivel, Mythileeswari Lakshmikanthan, Edwin Edward-Sam, et al. "Encapsulation of Phloroglucinol from Rosenvingea intricata Macroalgae with Zinc Oxide Nanoparticles against A549 Lung Cancer Cells." Pharmaceutics 16, no. 10 (2024): 1300. http://dx.doi.org/10.3390/pharmaceutics16101300.

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Background/Objectives: Phloroglucinol (PHL), a phenolic compound extracted from the brown alga Rosenvingea intricata, exhibits potent antioxidant and anticancer properties. This study aims to extract, purify, and characterize PHL, and further develop functionalized zinc oxide nanoparticles (ZnO NPs) loaded with PHL to enhance its therapeutic potential. Methods: PHL was extracted using acetone and purified through Sephadex LH-20 column chromatography, yielding a highly enriched fraction (F-3). The purified compound was characterized by FTIR, HPLC, NMR, and LC-MS. ZnO NPs were synthesized, PEGyl

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Lei, Gaoming, Chaoying Song, Xinyue Wen, Guoyu Gao, and Yanjie Qi. "Chemical Diversity and Potential Target Network of Woody Peony Flower Essential Oil from Eleven Representative Cultivars (Paeonia × suffruticosa Andr.)." Molecules 27, no. 9 (2022): 2829. http://dx.doi.org/10.3390/molecules27092829.

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Woody peony (Paeonia × suffruticosa Andr.) has many cultivars with genetic variances. The flower essential oil is valued in cosmetics and fragrances. This study was to investigate the chemical diversity of essential oils of eleven representative cultivars and their potential target network. Hydro-distillation afforded yields of 0.11–0.25%. Essential oils were analyzed by GC-MS and GC-FID which identified 105 compounds. Three clusters emerged from multivariate analysis, representative of phloroglucinol trimethyl ether (‘Caihui’), citronellol (‘Jingyu’, ‘Zhaofen’ and ‘Baiyuan Zhenghui’) and mixe

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Khaliullina, Alyona Sergeevna, Dilyara Khabilevna Shakirova, Leysan Airatovna Khairullina та ін. "EUCALYPTUS VIMINАLIS: CHEMICAL COMPOSITION, BIOLOGICAL ACTIVITY, STANDARDIZATION". Chemistry of plant raw material, № 1 (12 лютого 2024): 5–30. https://doi.org/10.14258/jcprm.20240112698.

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The review summarizes current literature data on the chemical composition diversity of Eucalyptus viminalis leaves, the biological activity of medicinal plant materials and the range of drugs they are based on. Eucalyptus metabolites belong to terpenoids, prenylated derivatives of phloroglucinol (acifloroglucinols), flavonoids, phenylpropanoids, coumarins, organic acids, vitamins, and other natural compounds. The phytochemical profile of the Eucalyptus viminalis terpene fraction is considered in the context of the chemical structure of the compound - the range of terpene content. Studies of re

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Malhão, Fernanda, Alice Abreu Ramos, Ana Catarina Macedo, and Eduardo Rocha. "Cytotoxicity of Seaweed Compounds, Alone or Combined to Reference Drugs, against Breast Cell Lines Cultured in 2D and 3D." Toxics 9, no. 2 (2021): 24. http://dx.doi.org/10.3390/toxics9020024.

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Seaweed bioactive compounds have shown anticancer activities in in vitro and in vivo studies. However, tests remain limited, with conflicting results, and effects in combination with anticancer drugs are even scarcer. Here, the cytotoxic effects of five seaweed compounds (astaxanthin, fucoidan, fucosterol, laminarin, and phloroglucinol) were tested alone and in combination with anticancer drugs (cisplatin—Cis; and doxorubicin—Dox), in breast cell lines (three breast cancer (BC) subtypes and one non-tumoral). The combinations revealed situations where seaweed compounds presented potentiation or

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Jagan, Enthai Ganeshan, Parth Sharma, Senthuran Sureshkumar, and Mohan Pandi. "Isolation of Taxol and Flavin-like fluorochrome from Endophytic Fungi of Mangifera indica." Journal of Pure and Applied Microbiology 15, no. 4 (2021): 2195–208. http://dx.doi.org/10.22207/jpam.15.4.43.

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Scouting for novel and plant-derived biomolecules from endophytic microbial sources draws greater focus on the discovery of novel bioactive metabolites. With this rationale, we scouted the endophytic fungi for taxol, an anticancer diterpenoid and fluorescent biomolecules. In the present study, about 31 endophytic fungal isolates recovered from the Mangifera indica leaves were screened for taxol production in M1D medium. About five isolates were shortlisted based on the thin layer chromatographic analysis of the fungal extracts. Among them Colletotrichum sp. MIP-5 has been identified as a produ

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Hoenigsberger, Michaela, Alexey Kopchinskiy, Christoph Bueschl, et al. "Volatiles from the Mandibular Gland Reservoir Content of Colobopsis explodens Laciny and Zettel, 2018, Worker Ants (Hymenoptera: Formicidae)." Molecules 24, no. 19 (2019): 3468. http://dx.doi.org/10.3390/molecules24193468.

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Forty-five volatile organic compounds (VOCs) were identified or annotated in the mandibular gland reservoir content (MGRC) of the Southeast Asian ant Colobopsis explodens Laciny and Zettel, 2018 (Hymenoptera: Formicidae), using headspace solid-phase microextraction (HS-SPME) coupled to gas chromatography mass spectrometry (GC-MS) and liquid extraction combined with GC-MS. In extension of previous reports on VOCs of C. explodens, members of different compound classes, such as alkanes, aliphatic and aromatic carboxylic acids, and phenolics, were detected. The ketone 2-heptanone and the biochemic

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Ghani, Mohmad Asri Abd, Dalia Abdallah, Peter M. Kazmaier, Barkev Keoshkerian, and Erwin Buncel. "Multi-armed, TEMPO-functionalized unimolecular initiators for starburst dendrimer synthesis via stable free radical polymerisation. 2. Tris (1,3,5)benzyloxy unimers." Canadian Journal of Chemistry 82, no. 9 (2004): 1403–12. http://dx.doi.org/10.1139/v04-106.

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The synthesis of the trifunctionalized TEMPO-modified unimolecular initiators, unimers I, II, and III is described. Unimer I was prepared via an SN2 type Williamson ether coupling of 1,3,5-tris(iodomethyl)benzene with a TEMPO-containing ethylbenzene hydroxy derivative. The synthesis of unimer II, however, was accomplished through SN1 reaction of 1,3,5-tris(bromomethyl)benzene with the hydroxy-ethylbenzene TEMPO derivative in the presence of silver triflate. Synthesis of unimer III started from phloroglucinol and an SNAr reaction with 1-fluoro-4-nitrobenzene, followed by reduction to the amino

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Kang, Sung-Myung, Seung-Hong Lee, Soo-Jin Heo, Kil-Nam Kim, and You-Jin Jeon. "Evaluation of antioxidant properties of a new compound, pyrogallol-phloroglucinol-6,6'-bieckol isolated from brown algae,Ecklonia cava." Nutrition Research and Practice 5, no. 6 (2011): 495. http://dx.doi.org/10.4162/nrp.2011.5.6.495.

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Abdel-Rahman, A. H., A. M. Khalil, S. I. El-Desoky, and E. M. Keshk. "ChemInform Abstract: Synthesis of Benzopyran-4-one and Phloroglucinol Monomethyl Ether Derivatives from the Naturally Occurring Compound (Visnagin)." ChemInform 31, no. 20 (2010): no. http://dx.doi.org/10.1002/chin.200020113.

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