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Journal articles on the topic 'Phlyctenular'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Khan, Shawn, Khushi Saigal, and Arash Maleki. "Conjunctival Phlyctenule and Nodular Scleritis in a Patient with Previous Herpes Simplex Virus-2 Exposure: Causative Agent or Innocent Bystander?" Case Reports in Ophthalmology 15, no. 1 (2024): 777–83. http://dx.doi.org/10.1159/000542076.

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Introduction: Phlyctenular keratoconjunctivitis is an inflammatory condition arising from a type IV hypersensitivity reaction, presenting with inflamed nodules on the conjunctiva and cornea. Scleritis is a severe ocular inflammation linked to systemic diseases, potentially vision threatening, and involving immune responses similar to phlyctenular keratoconjunctivitis. This case report discusses a patient with a history of herpes simplex virus (HSV)-2 infection who primarily developed phlyctenular conjunctivitis and later progressed to nodular scleritis. Case Presentation: A 66-year-old female

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2

Mondal, Dr Indrani. "Phlyctenular Keratoconjuctivitis and Tuberculosis." Journal of Medical Science And clinical Research 05, no. 06 (2017): 23692–93. http://dx.doi.org/10.18535/jmscr/v5i6.147.

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3

Jo, Yeon Ji, Jae Hyun Kim, and Jong Soo Lee. "The Therapeutic Effects of a 0.03% Tacrolimus Ointment on Childhood Phlyctenular Keratitis." Journal of the Korean Ophthalmological Society 62, no. 7 (2021): 888–94. http://dx.doi.org/10.3341/jkos.2021.62.7.888.

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Purpose: We explored the therapeutic effects of a 0.03% tacrolimus ointment (Protopic) on steroid-resistant phlyctenular keratitis in children. Methods: We enrolled seven eyes of five children with recurrent phlyctenular keratitis despite 3 months of steroid treatment. The topical steroids were tapered and the patients treated with a combination of 0.03% tacrolimus and 0.3% ofloxacin ointment. The logarithm of minimal angle of resolution (logMAR) visual acuity, corneal neovascularization status, and changes in corneal opacity between the baseline and final visit were checked on anterior photog

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4

Lahiri, Keya, Amruta Landge, Pallavi Gahlowt, Anand Bhattar, and Rajesh Rai. "Phlyctenular Conjunctivitis and Tuberculosis." Pediatric Infectious Disease Journal 34, no. 6 (2015): 675. http://dx.doi.org/10.1097/inf.0000000000000628.

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5

Madan, Siddharth, Sarita Beri, Maansi Sethi, Taru Garg, and Anita Nangia. "Lichen scrofulosorum and phlyctenular conjunctivitis." National Medical Journal of India 34, no. 1 (2021): 58. http://dx.doi.org/10.4103/0970-258x.323451.

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6

Venkateswaran, Nandini, Carolyn M. Kalsow, and Holly B. Hindman. "Phlyctenular Keratoconjunctivitis Associated withDolosigranulum pigrum." Ocular Immunology and Inflammation 22, no. 3 (2013): 242–45. http://dx.doi.org/10.3109/09273948.2013.841484.

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7

Rohatgi, J. "Phlyctenular Eye Disease A Reappraisal." Japanese Journal of Ophthalmology 44, no. 2 (2000): 146–50. http://dx.doi.org/10.1016/s0021-5155(99)00185-9.

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8

Ahn, Yong Sun, Jin A. Lee, and Yang Kyung Cho. "Corneal Perforation in Phlyctenular Keratitis." Journal of the Korean Ophthalmological Society 55, no. 2 (2014): 298. http://dx.doi.org/10.3341/jkos.2014.55.2.298.

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9

Sho, Ishikawa MD PhD ** Yasuhito Narita MD and Kei Shinoda MD PhD. "Efficacy of Azithromycin Hydrate Ophthalmic Solution for Meibomitis Related Keratoconjunctivitis." Mega Journal of Case Reports 7, no. 7 (2024): 2001–10. https://doi.org/10.5281/zenodo.12807012.

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AbstractPurpose: Meibomitis related keratoconjunctivitis (MRKC) is generally treated with a combination of antibacterial eye drops and low concentration steroids. Azithromycin hydrate ophthalmic solution s exhibit antibacterial and anti inflammatory effects. In the present study, we investigated the efficacy of azithromycin hydrate ophthalmic solution monotherapy for MRKC.Methods: Based on their medical records, patients with MRKC who visited Saitama Medical University Hospital between January 2020 and August 2022 and were treated with azithromycin eye drops as a single agent we

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10

Juberias, J. Ramón, Margarita Calonge, Javier Montero, José M. Herreras, and M. Antonia Saornil. "Phlyctenular keratoconjunctivitis a potentially blinding disorder." Ocular Immunology and Inflammation 4, no. 2 (1996): 119–23. http://dx.doi.org/10.3109/09273949609079642.

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11

Zh, Isserkepova. "TUBERCULOUS PHLYCTENULAR KERATOCONJUNCTIVITIS OF BOTH EYES (CLINICAL CASE)." Научно — практический журнал Фтизиопульмонология, no. 1 (July 14, 2023): 25–27. http://dx.doi.org/10.26212/2227-1937.2023.21.13.004.

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This article describes a clinical case of tuberculous phlyctenular keratoconjunctivitis of both eyes, which developed against the background of a recurrence of infiltrative tuberculosis of the right lung. This case is notable for the active nature of the specific process in both the eyes and the lungs. Although ocular tuberculosis typically develops later, this case suggests that it can occur earlier in patients with slow blood flow in the eyeball.

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12

EL HADY, HANAA, S. HUSSEIN, ASHRAF MOHAMED, and BADAWY ABD ELRAHIM. "ASSOCIATION BETWEEN PHLYCTENULAR CONJUNCTIVITIS AND INTESTINAL PARASITES." Journal of the Egyptian Society of Parasitology 45, no. 2 (2015): 315–20. http://dx.doi.org/10.21608/jesp.2015.89906.

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13

El Hady, Hanaa Ahmed, S. M. M. Hussein, and Ashraf Mustafa Mohamed. "Association between Phlyctenular Conjunctivitis and Intestinal Parasites." Journal of the Egyptian Society of Parasitology 45, no. 2 (2015): 315–20. http://dx.doi.org/10.12816/0017574.

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14

Katayama, Taiichiro, Yukari Yagi-Yaguchi, Osama Ibrahim, Jun Shimazaki, and Takefumi Yamaguchi. "Corneal higher-order aberrations in phlyctenular keratitis." Japanese Journal of Ophthalmology 64, no. 5 (2020): 478–84. http://dx.doi.org/10.1007/s10384-020-00759-8.

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15

Malhotra, Chintan, Monika Balyan, and ArunKumar Jain. "Multifocal phlyctenular conjunctivitis in association with pulmonary tuberculosis." Indian Journal of Ophthalmology 67, no. 7 (2019): 1177. http://dx.doi.org/10.4103/ijo.ijo_1657_18.

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16

Pandhi, Deepika, Jolly Rohatgi, Archana Singal, and Puneet Aggarwal. "Cutaneous tuberculosis and phlyctenular keratoconjunctivitis: A forgotten association." Indian Journal of Dermatology, Venereology and Leprology 72, no. 4 (2006): 290. http://dx.doi.org/10.4103/0378-6323.26726.

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17

Sathye, Sandeep Sudhakar. "Phlyctenular Conjunctivitis Treated with Homoeopathy: A Case Report." Homœopathic Links 34, no. 03 (2021): 235–40. http://dx.doi.org/10.1055/s-0041-1736385.

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AbstractPhlyctenular conjunctivitis (PC) is characterised by formation of a whitish nodule on bulbar conjunctiva near or at the limbus with a localised conjunctival congestion. It is considered as an allergic reaction to endogenous bacterial protein. Conventional treatment includes use of topical steroids in simple PC, but if there is some degree of secondary infection or corneal involvement then combined steroid-antibiotics are used though there are high chances of recurrence. Homoeopathic literature has medicines listed for PC. The case reported was a female aged 60 years suffering from PC i

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18

Culbertson, William W., Andrew J. W. Huang, Sid H. Mandelbaum, Stephen C. Pflugfelder, George T. Boozalis, and Darlene Miller. "Effective Treatment of Phlyctenular Keratoconjunctivitis with Oral Tetracycline." Ophthalmology 100, no. 9 (1993): 1358–66. http://dx.doi.org/10.1016/s0161-6420(93)31475-2.

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19

Suzuki, Tomo, Yoko Mitsuishi, Yoichiro Sano, Norihiko Yokoi, and Shigeru Kinoshita. "Phlyctenular Keratitis Associated With Meibomitis in Young Patients." American Journal of Ophthalmology 140, no. 1 (2005): 77.e1–77.e7. http://dx.doi.org/10.1016/j.ajo.2005.02.039.

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20

CAPUTO, ANTHONY R., KEVIN J. MICKEY, and SUQUIN GUO. "A Varicella-Induced Pupil Abnormality." Pediatrics 89, no. 4 (1992): 685–86. http://dx.doi.org/10.1542/peds.89.4.685a.

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To the Editor.— The varicella virus is a well known cause of ophthalmologic complications in its classic recurrent form of herpes zoster ophthalmicus. Ocular complications may also accompany the primary infection, however, and have been well documented. These conditions include vesicular lid lesions with corresponding irritation, phlyctenular keratoconjunctivitis, superficial punctate keratitis, uveitis, optic neuritis, and external ophthalmoplegia from encephalitic cranial nerve palsies.1,2 Internal ophthalmoplegia, a rare complication affecting pupillary constriction and accommodation, has a

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21

Bhandari, A., H. Bhandari, R. Shukla, and P. Giri. "Phlyctenular conjunctivitis: a rare association with spinal intramedullary tuberculoma." Case Reports 2014, mar18 1 (2014): bcr2013202010. http://dx.doi.org/10.1136/bcr-2013-202010.

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22

Oworu, Olugbemisola, Pouya Alaghband, and Colin Hutchinson. "Successful treatment of phlyctenular keratoconjunctivitis with topical cyclosporin A." Contact Lens and Anterior Eye 36, no. 5 (2013): 265–66. http://dx.doi.org/10.1016/j.clae.2013.02.008.

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23

El-Asrar, Ahmed M. Abu, J. J. Van Den Oord, K. Geboes, et al. "Phenotypic characterization of inflammatory cells in phlyctenular eye disease." Documenta Ophthalmologica 70, no. 4 (1988): 353–62. http://dx.doi.org/10.1007/bf00157065.

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24

Kang, Dong Hyun, Sang Wroul Song, Byung Yeop Kim, Kyu Yeon Hwang, and Kook Young Kim. "Clinical Aspects of Phlyctenular Keratoconjunctivitis Using a Tear Film Interferometer." Journal of the Korean Ophthalmological Society 61, no. 1 (2020): 1. http://dx.doi.org/10.3341/jkos.2020.61.1.1.

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25

Kumar, Pradeep, Taru Garg, Suparna Das, Smita Singh, and Siddhart Madan. "Lichen scrofulosorum coexisting with phlyctenular keratoconjuctivitis: Dermoscopy and ocular findings." Indian Dermatology Online Journal 12, no. 6 (2021): 941. http://dx.doi.org/10.4103/idoj.idoj_689_20.

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26

Kymionis, George D., Vardhaman P. Kankariya, and Georgios A. Kontadakis. "Tacrolimus Ointment 0.03% for Treatment of Refractory Childhood Phlyctenular Keratoconjunctivitis." Cornea 31, no. 8 (2012): 950–52. http://dx.doi.org/10.1097/ico.0b013e318243f69d.

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27

Thierry, Jean H. "CONTRIBUTION TOWARDS THE ELUCIDATION OF THE AETIOLOGY OF PHLYCTENULAR AFFECTIONS." Acta Ophthalmologica 15, no. 3 (2009): 355–58. http://dx.doi.org/10.1111/j.1755-3768.1937.tb04474.x.

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28

Hammersmith, K. M. "Topical Cyclosporine A in Severe Steroid-Dependent Childhood Phlyctenular Keratoconjunctivitis." Yearbook of Ophthalmology 2007 (January 2007): 103. http://dx.doi.org/10.1016/s0084-392x(08)70079-0.

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29

Doan, Serge, Eric Gabison, Damien Gatinel, Minh-Hanh Duong, Olivia Abitbol, and Thanh Hoang-Xuan. "Topical Cyclosporine A in Severe Steroid-Dependent Childhood Phlyctenular Keratoconjunctivitis." American Journal of Ophthalmology 141, no. 1 (2006): 62–66. http://dx.doi.org/10.1016/j.ajo.2005.08.035.

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30

Neiberg, Maryke N., and Joseph Sowka. "Phlyctenular keratoconjunctivitis in a patient with Staphylococcal blepharitis and ocular rosacea." Optometry - Journal of the American Optometric Association 79, no. 3 (2008): 133–37. http://dx.doi.org/10.1016/j.optm.2007.09.015.

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31

Jo, Dong Hyun, Mee Kum Kim, Won Ryang Wee, and Jin Hak Lee. "Analysis of Clinical Characteristics in Phlyctenular Keratoconjunctivitis at a Tertiary Center." Journal of the Korean Ophthalmological Society 52, no. 1 (2011): 7. http://dx.doi.org/10.3341/jkos.2011.52.1.7.

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32

Shrestha, GauriShankar, Pragati Gautam, and AnandaKumar Sharma. "Phlyctenular keratoconjunctivitis among children in the tertiary eye hospital of Kathmandu, Nepal." Oman Journal of Ophthalmology 8, no. 3 (2015): 147. http://dx.doi.org/10.4103/0974-620x.169884.

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33

Yoon, Chang Ho, Mee Kum Kim, and Joo Youn Oh. "Topical Tacrolimus 0.03% for Maintenance Therapy in Steroid-Dependent, Recurrent Phlyctenular Keratoconjunctivitis." Cornea 37, no. 2 (2018): 168–71. http://dx.doi.org/10.1097/ico.0000000000001440.

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34

Doan, Serge, Eric Gabison, Frédéric Chiambaretta, Melissa Touati, and Isabelle Cochereau. "Efficacy of azithromycin 1.5% eye drops in childhood ocular rosacea with phlyctenular blepharokeratoconjunctivitis." Journal of Ophthalmic Inflammation and Infection 3, no. 1 (2013): 38. http://dx.doi.org/10.1186/1869-5760-3-38.

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35

Kaur, Amanjot, Sujata Das, and Smruti Rekha Priyadarshini. "Case Report: Managing a case of Tubercular Phlycten presenting as Sterile Corneal Perforation." F1000Research 13 (January 3, 2024): 10. http://dx.doi.org/10.12688/f1000research.138371.1.

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A 22-year-old Indian male presented with a sterile perforation at 5 o’clock in the left eye, and a visual acuity of 20/80. A month prior to presentation, he had nodular lesion in lower part of left cornea and was undergoing medical management from a local ophthalmologist. After ocular and systemic examination, probable diagnosis of phlyctenular keratoconjunctivitis (PKC) was established. Since the perforation was large and not amenable to application of tissue adhesives, it was managed with a corneal patch graft. After investigations, we found that this was a case of latent tuberculosis infect

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36

Wiriyachai, Thakoon, Sophida Boonsathorn, Nopporn Apiwattanakul, and Surapat Assawawiroonhakarn. "A rare case of primary sinonasal tuberculosis presented with phlyctenular keratoconjunctivitis in a pediatric patient." Medicine 100, no. 7 (2021): e24787. http://dx.doi.org/10.1097/md.0000000000024787.

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37

Dr, K. Priyanka, Y. M. S. Prasad Dr, P. R. Siva Sankar Dr, and Hari Hara Prasad Dr. "A Case Series of Ocular Manifestations in Tuberculosis." A Case Series of Ocular Manifestations in Tuberculosis 9, no. 1 (2024): 4. https://doi.org/10.5281/zenodo.10628906.

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To evaluate and understand the clinical manifestation and prevalence of ocular morbidity in Pulmonary tuberculosis patients. Lungs are primarily affected by Tuberculosis. Secondary involvement may occur in any organ including eye. Any part of the eye could potentially be affected by TB and its clinical manifestations can vary. Materials & Methods : A hospital based observational study was conducted in government general hospital, Ananthapuramu for a period of 6 months from December 2022 to May 2023.Patients who were diagnosed as systemic tuberculosis on ATT were evaluated for ophthalmic in

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38

Sonomura, Yukiko, Norihiko Yokoi, Aoi Komuro, Hiroaki Kato, and Chie Sotozono. "The Features and Treatment Effects on Keratoepitheliopathy for Meibomitis-Related Keratoconjunctivitis." Diagnostics 14, no. 5 (2024): 487. http://dx.doi.org/10.3390/diagnostics14050487.

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Meibomitis-related keratoconjunctivitis (MRKC) is characterized by meibomitis with corneal epithelial abnormalities, and can be divided into two types: MRKC accompanied with phlyctenular keratitis, and MRKC accompanied with keratoepitheliopathy that is similar to superficial punctate keratopathy (SPK). The purpose of this retrospective study was to investigate the characteristic features of keratoepitheliopathy and treatment outcomes for MRKC. This study involved 27 eyes of 18 MRKC patients (3 males and 15 females). National Eye Institute (NEI) scores and visual acuity were compared at pre and

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39

Stavros, Sofoklis, Anastasios Potiris, Angeliki Gerede, et al. "Methotrexate-Induced Toxicity After Ultrasound-Guided Intragestational Injection in a Patient with Caesarean Scar Pregnancy—A Case Report." Medicina 60, no. 11 (2024): 1900. http://dx.doi.org/10.3390/medicina60111900.

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Background and Objectives: Caesarean scar pregnancy (CSP) is a rare form of ectopic pregnancy in which the early pregnancy implants at the site of the uterine scar. Methotrexate (MTX) in lower doses can be used to treat CSPs. However, MTX administration is associated with a spectrum of side effects that include hematological toxicities. This case report presents a CSP treated with an intragestational injection of MTX and subsequently developed pancytopenia. Materials and Methods: A 23-year-old woman at six weeks and six days of pregnancy was referred as a potential case of CSP. After establish

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40

Doll, Tracy. "Cryopreserved Amniotic Membrane, Autologous Serum Eye Drops, and Tea-Tree Oil Lid Scrubs in combination for the treatment of Keratoconjunctivitis in a Staphylococcus Hypersensitive Teenager." Journal of Dry Eye Disease 1, no. 1 (2017): e1-e10. http://dx.doi.org/10.22374/jded.v1i1.1.

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Abstract Background and Objective: The purpose is to present an interventional case report detailing recurrent bilateral keratoconjunctivitis secondary to Staphylococcus hypersensitivity in a teenage female. At least three times yearly, for five years, the patient has experienced episodes of severe bilateral catarrhal infiltrative or phlyctenular keratoconjunctivitis. Comprehensive corneal and conjunctival cultures had been historically performed, twice, yielding only growth of Staphylococcus aureus and epidermidis. Prior short-term treatment regimens of topical steroids and antibiotics

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41

Alkaissi, Hussam R., Alaa Kubbar, and MaryAnn Banerji. "Pachydermoperiostosis: A Rare Masquerader of Acromegaly and Thyroid Acropachy." Journal of the Endocrine Society 5, Supplement_1 (2021): A595—A596. http://dx.doi.org/10.1210/jendso/bvab048.1214.

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Abstract Background: Pachydermoperiostoasis is a rare disease of prostaglandin metabolism that presents with extensive clubbing, skin thickening, and enlargement of hands and feet, often misdiagnosed as acromegaly or thyroid acropachy. Clinical Case: A 29-year-old male presented with progressive enlargement of hands and feet for the past three years, with increased sweating, seborrhea, acne, arthralgia, and photophobia. On examination, facial furrowing and severe clubbing in all fingers and toes was noticed, with palmoplantar hyperhidrosis, tenderness and widening around distal forearms, and i

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42

Suzuki, Tomo, and Shigeru Kinoshita. "Dual Role of Cutibacterium acnes: Commensal Bacterium and Pathogen in Ocular Diseases." Microorganisms 12, no. 8 (2024): 1649. http://dx.doi.org/10.3390/microorganisms12081649.

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Microbiota present around the ocular surface, encompassing the eyelid skin, the conjunctival sac, and the meibomian glands, play a significant role in various inflammatory conditions associated with the ocular surface. Cutibacterium acnes (C. acnes), formerly, Propionibacterium acnes, is one of the most predominant commensal bacteria and its relative abundance declines with aging. However, it can act as both an infectious and an immunogenic pathogen. As an infectious pathogen, C. acnes has been reported to cause late onset endophthalmitis post-cataract surgery and infectious keratitis. On the

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43

Hsieh, Chen-Hsi, Pei-Wei Shueng, Shih-Chiang Lin, et al. "Helical Irradiation of the Total Skin with Dose Painting to Replace Total Skin Electron Beam Therapy for Therapy-Refractory Cutaneous CD4+ T-Cell Lymphoma." BioMed Research International 2013 (2013): 1–11. http://dx.doi.org/10.1155/2013/717589.

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A 36-year-old woman was diagnosed with a therapy-refractory cutaneous CD4+ T-cell lymphoma, T3N0M0B0, and stage IIB. Helical irradiation of the total skin (HITS) and dose painting techniques, with 30 Gy in 40 fractions interrupted at 20 fractions with one week resting, 4 times per week were prescribed. The diving suit was dressed whole body to increase the superficial dose and using central core complete block (CCCB) technique for reducing the internal organ dose. The mean doses of critical organs of head, chest, and abdomen were 2.1 to 29.9 Gy, 2.9 to 8.1 Gy, and 3.6 to 15.7 Gy, respectively.

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44

Björkenheim, Barbro. "THE PATHOGENESIS OF EYE PHLYCTENULES WITH SPECIAL REFERENCE TO THE ROLE OF β-HEMOLYTIC STREPTOCOCCI". Acta Ophthalmologica 27, № 3 (2009): 437–54. http://dx.doi.org/10.1111/j.1755-3768.1949.tb05851.x.

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45

M, Tomar, Sharma G, and Sood T. "Phlyctenular Conjunctivitis and Tuberculosis." International Journal of Ophthalmology & Eye Science, July 7, 2016, 233–36. http://dx.doi.org/10.19070/2332-290x-1600048.

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46

"CHAPTER XXII: Phlyctenular Ophthalmia." Acta Ophthalmologica 43, S85 (2009): 151–54. http://dx.doi.org/10.1111/j.1755-3768.1965.tb06416.x.

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47

Tomar, M., G. Sharma, and T. Sood. "Phlyctenular Conjunctivitis and Tuberculosis." July 7, 2016. https://doi.org/10.19070/2332-290X-1600048.

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Introduction: Phlyctenular keratoconjunctivitis is a nodular affliction characterized by the formation of a small, circumscribed lesion at the corneal limbus and now accepted as a morphologic expression of delayed hypersensitivity to diverse antigens. The condition is one of several corneal disorders that arise as an expression of altered immune mechanisms [4]. Materials and Methods: A 2.5 years old male child presented with a history of watering and redness from his left eye since 3-4 days. On ocular examination, an elevated nodule of approximately 2x1 mm in size with central erosion at 1‘0 c

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48

Abu El Asrar, AhmedM, Karel Geboes, PrabhatC Maudgal, MohamedH Emarah, Luc Missotten, and Valeer Desmet. "Immunocytological study of phlyctenular eye disease." International Ophthalmology 10, no. 1 (1987). http://dx.doi.org/10.1007/bf00202779.

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49

Chen, Ying-Yi, Yi-Chen Sun, Chia-Ying Tsai, et al. "Spectral-domain optical coherence tomography for evaluating palisades of Vogt in ocular surface disorders with limbal involvement." Scientific Reports 11, no. 1 (2021). http://dx.doi.org/10.1038/s41598-021-91999-2.

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AbstractSpectral-domain optical coherence tomography (SD-OCT) has been used to observe the morphology of the palisades of Vogt (POV) with satisfactory resolutions. In this study, we used SD-OCT to examine the microstructure of the POV in ocular surface disorders with limbal involvement. We detect subclinical limbal pathologies based on five parameters, including (1) decreased epithelial thickness, (2) loss of the sharp stromal tip, (3) loss of the smooth epithelial-stromal interface, (4) dilated stromal vessels, and (5) decreased POV density. Eighteen eyes of 10 patients with advancing wavelik

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50

Eleiwa, Taher K., Ayman Elmaghrabi, Hend G. Helal, Samar N. Abdelrahman, Reem H. ElSheikh, and Abdelrahman M. Elhusseiny. "Phlyctenular Keratoconjunctivitis in a Patient With COVID-19 Infection." Cornea Publish Ahead of Print (July 28, 2021). http://dx.doi.org/10.1097/ico.0000000000002789.

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