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Dissertations / Theses on the topic 'Phosphatidic acid'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 May 2024

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1

Lee, Sue Chin. "Spatial signalling of phosphatidic acid." Thesis, University of Strathclyde, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.510804.

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2

Fleming, Ian Neil. "Purification and properties of phosphatidic acid phosphohydrolase." Thesis, University of Newcastle Upon Tyne, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.260059.

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3

Stace, Catherine Lucy. "Functional studies of phosphatidic acid production by phospholipase D1." Thesis, University of Cambridge, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.612984.

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4

Jakobson, Katherine. "The role of phosphatidic acid in astrocyte intracellular signalling." Thesis, Open University, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.293615.

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5

Han, Eun Hyang. "Phosphatidic Acid Mediation of Environmentally Induced Adaptive Growth Responses." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1492678342062212.

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6

Buckland, Andrew G. "Anionic phospholipids, annexins and the activity of phospholipases A2." Thesis, University of Southampton, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.246259.

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7

Heyward, Catherine Anne. "Investigation of potential phosphatidic acid target proteins in intracellular signalling pathways." Thesis, Birmingham City University, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.479113.

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8

Williams, David. "Phosphatidic Acid Increases Lean Body Tissue and Strength In Resistance Trained Men." Master's thesis, University of Central Florida, 2012. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/5575.

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Phosphatidic Acid (PA) is a natural phospholipid compound derived from lecithin which is commonly found in egg yolk, grains, fish, soybeans, peanuts and yeast. It has been suggested that PA is involved in several intracellular processes associated with muscle hypertrophy. Specifically, PA has been reported to activate protein synthesis through the mammalian target of rapamycin (mTOR) signaling pathway and thereby may enhance the anabolic effects of resistance training. To our knowledge, no one has examined the effect of PA supplementation in humans while undergoing a progressive resistance t

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9

Yu, Changhua. "Phospholipase D/phosphatidic acid phosphatase signal transduction pathway in post-infarction congestive heart failure." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp04/mq23565.pdf.

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10

Urs, Aarti N. "Reciprocal binding of sphingosine and phosphatidic acid to steroidogenic factor 1 regulates the transcription of CYP17." Thesis, Available online, Georgia Institute of Technology, 2005, 2005. http://etd.gatech.edu/theses/available/etd-11212005-102620/.

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Thesis (M. S.)--Biology, Georgia Institute of Technology, 2006.<br>Donald Doyle, Committee Member ; Harish Radhakrishna, Committee Member ; Alfred Merrill, Committee Member ; Marion Sewer, Committee Chair Includes bibliographical references.

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11

Lucas, Andrew Thomas. "Structural Basis for Dishevelled-2 Association to the Plasma Membrane." Thesis, Virginia Tech, 2010. http://hdl.handle.net/10919/76974.

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The Wingless (Wnt) signaling pathway is one of the critical developmental pathways for control of cell differentiation, proliferation, and cell growth. The DEP domain, located on the C-terminus of Dishevelled (Dvl), plays a role in cytoplasm-membrane association, which branches the canonical and non-canonical Wnt signaling pathway within the cell. It has been suggested that the DEP domain requires the recruitment of ionic lipids, such as phosphatidic acid, to regulate its localization to the plasma membrane and association to the frizzle receptor. However, the physical mechanism for DEP associ

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Cazzolli, Rosanna St Vincents Campus UNSW. "The effects of linoleate on insulin action in skeletal muscle cells." Awarded by:University of New South Wales. St Vincents Campus, 2005. http://handle.unsw.edu.au/1959.4/22925.

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Emerging evidence suggests that an important mechanism for the negative feedback control of insulin signalling involves the inhibition of tyrosine phosphorylation of IRS-1 by its prior serine/threonine (ser/thr) phosphorylation. IRS-1 ser/thr phosphorylation has been linked to the dissociation of IRS-1 from the insulin receptor and PI3K, and its degradation via a proteasome-dependent pathway. Studies in animal models have shown that increases in plasma free fatty acids (FFAs) are associated with reduced IRS-1-signalling, and so it has been postulated that elevated FFA cause insulin resistance

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13

Grkovich, Andrej. "The function, activation and inhibition of phosphatidic acid phosphohydrolase-1 and group IVA phospholipase A2 in toll-like receptor-4 activated macrophages." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2008. http://wwwlib.umi.com/cr/ucsd/fullcit?p3300700.

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Thesis (Ph. D.)--University of California, San Diego, 2008.<br>Title from first page of PDF file (viewed April 7, 2008). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 174-187).

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14

Ishida, Takeshi. "The expression of phosphatidic acid phosphatase 2a, which hydrolyzes lipids to generate diacylglycerol, is regulated by p73, a member of the p53 family." Kyoto University, 2007. http://hdl.handle.net/2433/135691.

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15

Wattelet, Valérie. "Rôle des acide lysophosphatidique acyltransférases dans la voie sécrétoire chez les plantes." Thesis, Bordeaux, 2019. http://www.theses.fr/2019BORD0333.

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Chez les eucaryotes, les lipides membranaires sont essentiels à la compartimentation et la régulation des voies de sécrétion. Par leurs propriétés physiques, ils sont essentiels aux courbures membranaires et à la régulation de la morphodynamique des endomembranes, de la morphologie des organites et de la formation des vésicules de transport. Chez l’animal, les acide lysophosphatidique acyltransférases (LPAATs) sont impliquées dans la régulation du trafic endomembranaire, mais rien n’est connu sur leur rôle chez la plante. Chez Arabidopsis thaliana, cinq LPAATs ont été identifiées. Nous avons d

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Djafi, Nabila. "Etude des rôles des diacylglycérol kinases chez Arabidopsis thaliana par des approches pharmacologiques et par génétique inverse." Thesis, Paris 6, 2014. http://www.theses.fr/2014PA066021.

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Les diacylglycerol kinases catalysent la phosphorylation du diacylglycérol en acide phosphatidique. Nous avons montré que la PLC spécifique des phosphoinositide (PI-PLC) et la diacylglycérol kinase (DGK) régulent négativement l'expression basale de la plupart des gènes DREB2 dans les cellules en suspension d'Arabidopsis thaliana. Les gènes DREB2 codent pour des facteurs de transcription qui se lient aux motifs DRE (Drought Responsive Elements). Ces éléments sont également liés par les facteurs DREB1. Alors que les facteurs DREB2 sont principalement impliqués dans les réponses à la sécheresse e

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17

Arana-Ceballos, Fernando Alberto. "Biochemical and physiological studies of Arabidopsis thaliana Diacylglycerol Kinase 7 (AtDGK7)." Phd thesis, kostenfrei, 2006. http://opus.kobv.de/ubp/volltexte/2007/1372/.

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18

Platre, Matthieu. "Localisation et fonction des lipides anioniques dans l'organisation cellulaire et le développement des plantes." Thesis, Lyon, 2017. http://www.theses.fr/2017LYSEN098.

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Les cellules eucaryotes possèdent un territoire membranaire dit « électrostatique » qui est définit par la présence de phospholipides négativement chargés sur la face cytosolique des membranes. Cette propriété permet le recrutement de protéine cytosolique contenant des motifs/domaines positivement chargés au niveau des membranes via des interactions électrostatiques. Nous nous sommes demandés si le territoire électrostatique est présent chez les cellules végétales et quel est son organisation ? Quels sont le(s) lipide(s) anionique(s) impliqués dans son maintien ? Et quel est son (ces) rôle(s)

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19

Putta, Priya. "The Tale/ Head of Two Membrane Lipids Through Protein Interactions." Kent State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=kent1524311387080992.

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20

Kassas, Nawal. "DIfférentes espèces d'acide phosphatidique : localisations subcellulaires et fonctions biologiques spécifiques." Thesis, Strasbourg, 2014. http://www.theses.fr/2014STRAJ069.

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L’acide phosphatidique (PA) est un lipide simple qui peut exister sous différentes formes. A partir des sondes que j’ai préparé en se basant sur des domaines de liaison au PA : PDE4A1, Spo20p, et OpiQ2, j’ai pu étudier la localisation subcellulaire du PA dans les cellules PC12 et les macrophages RAW264.7. Ces sondes lient différents formes de PA dans les membranes de différents compartiments subcellulaires. De plus, j’ai pu montrer qu’il y a une néosynthèse de PA et de certaines espèces de PA mono- ou bi-insaturé à la membrane plasmique lors de la stimulation de l’exocytose. Nous avons ainsi o

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21

Orive, Milla Nuria. "Design of a new biological platform for the production of glycoglycerolipids." Doctoral thesis, Universitat Ramon Llull, 2020. http://hdl.handle.net/10803/669862.

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Els glicolípids són producte d’alt valor degut a les seves propietats amfipàtiques que els doten d’un ampli rang d’aplicacions en els sectors químic (ex., biosurfactants) o biomèdic (ex., adjuvant de vacunes). Depenent de la unitat lipídica que els forma aquests compostos poden ser classificats en diferents famílies. Si la unitat lpídica és una ceramida o diacilglicerol, el glicolípid resultant es coneixerà com a glicoesfingolípid o glicoglicerolípid (GGL) respectivament. Mentre que els glicoesfingolípids han demostrat jugar un paper clau en diversos processos biològics, els glicoglicerolípids

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22

Djafi, Nabila. "Etude des rôles des diacylglycérol kinases chez Arabidopsis thaliana par des approches pharmacologiques et par génétique inverse." Electronic Thesis or Diss., Paris 6, 2014. http://www.theses.fr/2014PA066021.

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Les diacylglycerol kinases catalysent la phosphorylation du diacylglycérol en acide phosphatidique. Nous avons montré que la PLC spécifique des phosphoinositide (PI-PLC) et la diacylglycérol kinase (DGK) régulent négativement l'expression basale de la plupart des gènes DREB2 dans les cellules en suspension d'Arabidopsis thaliana. Les gènes DREB2 codent pour des facteurs de transcription qui se lient aux motifs DRE (Drought Responsive Elements). Ces éléments sont également liés par les facteurs DREB1. Alors que les facteurs DREB2 sont principalement impliqués dans les réponses à la sécheresse e

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23

Napoli, Andrea. "Glycerophospholipid fluorescence imaging during vaccinia virus replication." Thesis, Sorbonne Paris Cité, 2019. https://theses.md.univ-paris-diderot.fr/NAPOLI_Andrea_1_va_20190415.pdf.

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Le virus de la vaccine (VACV) est l'organisme modèle pour l'étude des Poxviridae. Son cycle de réplication dans le cytoplasme de la cellule hôte a été largement étudié par microscopie optique et microscopie électronique. Grâce à des études génétiques approfondies, le rôle de certaines des 250 protéines du virus a été élucidé. Cependant, les mécanismes d’acquisition de la membrane du virus, notamment le rôle des lipides cellulaires impliqués, restent mal connus. L’étude de la composition des membranes de VACV purifiés par spectrométrie de masse a montré qu’elles présentent un enrichissement en

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24

Repová, Romana. "Studium interakce záporně nabitých vezikulárních systémů s polykationty." Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2020. http://www.nusl.cz/ntk/nusl-414178.

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This diploma thesis deals with the preparation and characterization of negatively charged catanionic vesicular systems and their combination with selected polycations. The catanionic vesicular system was prepared by mixing of two oppositely charged surfactants SDS and CTAB. The negative charge as well as the stability of the vesicular system was provided by the incorporation of phosphatidic acid. Polycations, DEAE and TMC, have been selected for use in a pharmaceutical applications. Characterization of the prepared systems was performed by measuring DLS and ELS. The results indicate that we we

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25

Tanguy, Emeline. "Implication de l’acide phosphatidique dans le trafic membranaire : rôle et régulation de la phospholipase D au cours de la phagocytose et de l’exocytose régulée." Thesis, Strasbourg, 2019. http://www.theses.fr/2019STRAJ112.

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La mise en évidence du rôle des lipides dans le trafic membranaire fait partie des avancées majeures de ces dernières années. Mes travaux de thèse se sont focalisés sur le plus simple des phospholipides, l’acide phosphatidique (PA). La production de PA par la phospholipase D (PLD) joue un rôle crucial au cours de la phagocytose et l’exocytose régulée, mais la dynamique de sa formation, tout comme les mécanismes d’action des différentes formes de PA, restent à ce jour totalement inconnus. Durant mon doctorat, j’ai contribué à la caractérisation de trois domaines de liaison peptidique au PA, qui

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26

Violet, Pierre-Christian. "Rôle des lipides-phosphate phosphatases dans la modulation des voies de signalisation impliquées dans les léiomyomes utérins." Phd thesis, Université Paris Sud - Paris XI, 2012. http://tel.archives-ouvertes.fr/tel-00788479.

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Le léiomyome utérin est la pathologie utérine la plus fréquente chez les femmes en âges de procréer. Des résultats précédent obtenus avec les cellules ELT3, une lignée de cellules de léiomyomes de rat, ont montré que l'acide lysophosphatidique (LPA) activait les MAP kinases ERK1/2 via le récepteur LPA1 couplé à la protéine Gi et l'activation de Raf, Ras et de MEK. Durant ce travail, nous avons caractérisé l'activité phosphatase responsable de la dégradation du LPA dans cette lignée de cellules ELT3. Nous avons montré que le LPA était dégradé exclusivement par la lipide-phosphate phosphatase 1

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27

Szabová, Jana. "Příprava a charakterizace komplexních liposomálních systémů pro distribuci léčiv." Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2019. http://www.nusl.cz/ntk/nusl-401880.

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This diploma thesis deals with the preparation and characterization of stealth liposomes and their combination with trimethylchitosan (TMC). This complex could find application in the field of inhalation administration. Stealth liposomes were prepared from neutral phophatidylcholine, negatively charged fosfatidic acid and polyethyleneglycol bounded to phosphatidylethanolamine. We have managed to prepare stealth liposomes with suitable properties that should guarantee passive targeting without evocation an immune response, despite the content of the negative component. We also found a suitable

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28

Ammar, Mohamed Raafet. "Rôle de la phospholipase D1 dans le trafic membranaire : implication dans le développement neuronal et l'exocytose régulée." Phd thesis, Université de Strasbourg, 2013. http://tel.archives-ouvertes.fr/tel-00998047.

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La croissance neuritique est un mécanisme complexe qui fait toujours l'objet d'intenses investigations. Les donnés actuelles ont permis de mettre en évidence l'implication de trois mécanismes principaux dans la croissance neuritique : i) la dynamique du cytosquelette, ii) le trafic intracellulaire et l'apport membranaire au niveau du cône de croissance et iii) la signalisation cellulaire, principalement via la voie MAPK-ERK1/2, qui abouti à la régulation de la transcription.La PLD1 et son produit l'acide phosphatidique semblent être au centre de voies majeures impliquées dans le développement

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Wang, Qili. "Interaction entre la sous unité V0 de la V-ATPase et le facteur d'échange ARNO et son implication fonctionnelle dans l'exocytose régulée." Thesis, Strasbourg, 2019. http://www.theses.fr/2019STRAJ049.

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Alors que s’accumulent des données épidémiologiques qui suggèrent une importance fondamentale des lipides de l’alimentation dans l’homéostasie cellulaire et le développement de nombreuses pathologies humaines, peu d’informations sur leurs fonctions spécifiques sont disponibles à ce jour. Ceci est particulièrement le cas pour la neurosecrétion qui dépend de la fusion d’organites vésiculaires avec la membrane plasmique. Des études récentes ont montré le rôle clé de la compartimentalisation lipidique au niveau des sites d’exocytose et par ailleurs validées la notion de lipides fusogéniques, comme

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30

Gutiérrez, Martínez Enric. "Función de la fosfatasa de fosfolípidos 3 (LPP3) en las etapas tempranas de la vía secretora." Doctoral thesis, Universitat de Barcelona, 2013. http://hdl.handle.net/10803/134353.

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El complejo de Golgi participa en el procesamiento, la distribución y el transporte de lípidos y proteínas hacia su destino final dentro de la célula. El transporte desde el Golgi está mediado por intermediarios de transporte (ITs), principalmente vesículas y túbulos. La formación de ITs se inicia con la gemación de la vesícula o el túbulo, a continuación se produce su elongación y finalmente tiene lugar su fisión. Este proceso requiere de una compleja maquinaria molecular en la que intervienen las llamadas proteínas de cubierta, proteínas motoras asociadas al citoesqueleto, y los lípidos de l

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31

Ragon, Mélanie. "La phytase de Debaryomyces castellii CBS 2923 : surexpression, propriétés catalytiques et structure." Montpellier 2, 2006. http://www.theses.fr/2006MON20130.

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32

Wagh, Purnima Kamlakar. "EPOXYGENASE EXPRESSION IN SOYBEAN AND BIOLOGICAL EFFECTS OF EPOXY FATTY ACIDS." UKnowledge, 2006. http://uknowledge.uky.edu/gradschool_theses/384.

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Epoxy fatty acids (EXA) are valuable to industry as they are used in synthesizing plasticizers such as of poly vinyl chloride, resins, adhesives, coating materials such as paint, lubricant, lubricant additives, insecticides, insect repellants, crop oil concentrates and formulations of carriers for slow release pesticides and herbicides. There is interest in developing commercial oilseeds accumulating epoxy fatty acids to at least 50% of the seed oil. Soybeans are the most widely cultivated oilseed and its oil has high levels of linoleic acid which can be a substrate for epoxygenase enzymes. Ca

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33

Wang, Hua. "PART I: FORMATION, PROTEIN MODIFICATION, AND CELLULAR METABOLISM OF 4-HYDROXY-7-OXOHEPT-5-ENOIC ACID LACTONE (HOHA-LACTONE)PART II: DETECTION AND BIOLOGICAL ACTIVITIES OF CARBOXYETHYLPYRROLE (CEP)-PHOSPHATIDYL-ETHANOLAMINE AND METABOLISM OF CEP-LYSINE." Case Western Reserve University School of Graduate Studies / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=case1386252158.

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34

Williams, Sean Angela. "Divergent changes in cardiac phospholipase D-phosphatidic acid phosphatase activities during insulin-dependent diabetes." 1995. http://hdl.handle.net/1993/19039.

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35

CHENG, SHIH-CHUEH, та 鄭士珏. "Using quercetin and rosmarinic acid encapsulated into phosphatidic acid liposomes grafted with apolipoprotein E for inhibition of SK-N-MC cells against β-amyloid induced phosphorylation of mitogen-activated protein kinases and deposit". Thesis, 2016. http://ndltd.ncl.edu.tw/handle/67ght3.

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碩士<br>國立中正大學<br>化學工程研究所<br>104<br>Liposomes containing phosphatidic acid (PA) and with a modified ApoE peptide encapsulate quercetin (QU) and rosmarinic acid (RA) as drug carrier to explore PA on protein phosphorylation targeting treatment. In this study, we used β-Amyloid (Aβ) to induce phosphorylation of protein in SK-N-MC cells for simulating Alzheimer’s disease (AD) in vitro model. In AD vitro model, the experimental results show that Aβ-induced SK-N-MC cells, JNK and ERK and p38 protein phosphorylation (p-JNK: 0.98; p-ERK: 0.89; p-p38: 0.89) was significantly higher than the control group

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Tzu-Yu, Hung, та 洪紫瑜. "Quercetin and Rosmarinic Acid Encapsulated Into Phosphatidic Acid Liposomes Grafted With Apolipoprotein E for Transporting across the In Vitro Blood–Brain Barrier and Protection of SK-N-MC Cells Against β-amyloid Peptide-Induced Degeneration". Thesis, 2014. http://ndltd.ncl.edu.tw/handle/9qmjju.

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碩士<br>國立中正大學<br>化學工程研究所<br>102<br>Liposomes containing phosphatidic acid and with a modified ApoE peptide encapsulate quercetin and rosmarinic acid (RA) as drug carrier. Comparing the cellular uptake enhance effect of Tween 80 to ApoE. The cell co-culture model was established by consisting of human brain-microvascular endothelial cells (HBMECs), human brain vascular pericytes (HBVPs) and human astrocytes (HAs) to investigate quercetin and RA permeability of the in vitro blood–brain barrier (BBB) model, and then the protective effect of quercetin and RA against the in vitro Alzheimer’s disease

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WANG, YI-XIN, and 王奕心. "Resveratrol and Epigallocatechin Gallate Encapsulated into Phosphatidic Acid Liposomes Grafted with Leptin Across the Blood‒Brain Barrier to Protect SH-SY5Y Cells Against 1-Methyl-4-Phenylpyridinium Induced for Parkinson’s Disease Therapy." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/4n74qv.

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碩士<br>國立中正大學<br>化學工程研究所<br>105<br>Liposomes containing 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC), cholesterol, dihexadecyl phosphate (DHDP) and 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphate (PA) surface was modified with leptin as drug carriers for hydrophobic, resveratrol (RES) and hydrophilic, epigallocatechin gallate (EGCG) to across the blood‒brain barrier. The cellular uptake of the liposomes has been enhanced by the incorporation of PA and leptin (lep). The protective effect of RES and EGCG against the in vitro Parkinson’s disease (PD) neurodegenerative model was established by SH-

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Rajpal, Ashdeep Kaur. "Design and Synthesis of Metabolically Stabilized Lipid Probes for the Investigation of Protein–Lipid Binding Interactions." 2011. http://trace.tennessee.edu/utk_gradthes/905.

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Protein–lipid binding interactions play crucial roles in various physiological and pathological processes, making it very important to study these interactions at the molecular level. However, investigation of these interactions is complicated by several issues, including the inherent complexity of membranes as well as the diverse mechanisms by which proteins interact with the membrane surfaces. As a result, many of these interactions remain poorly characterized. Synthetic probes are useful tools employed for studying protein–lipid binding interactions. This thesis will detail the design and

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Bezvoda, Radek. "Úloha fosfolipáz D a lipid fosfát fosfatáz v regulaci buněčné morfogeneze rostlin." Doctoral thesis, 2014. http://www.nusl.cz/ntk/nusl-338035.

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of the thesis The presented work explores the function and regulation of intracellular signaling that utilizes phospholipase D (PLD) and phosphatidic acid (PA), especially in the context of cellular morphogenesis of plants. PLDs cleave membrane phospholipids to phosphatidic acid, which has important biophysical and signaling role in many contexts, such as stress response, regulation of cytoskeletal dynamics and vesicular transport. Vesicular transport is essential in focused tip growth of plant pollen tubes and root hairs. Part of the work deals with NADPH oxidases, that are an emerging counte

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De, Jager P. C. (Pieter Christiaan). "A phosphate sorption and desorption study on an acid sandy clay soil." Diss., 2002. http://hdl.handle.net/2263/29024.

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