Relevant bibliographies by topics / Phosphatidylinositol-4-phosphate 5-kinase de type 1

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Academic literature on the topic 'Phosphatidylinositol-4-phosphate 5-kinase de type 1'

Author: Grafiati
Published: 7 October 2023
Last updated: 31 July 2025

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Journal articles on the topic "Phosphatidylinositol-4-phosphate 5-kinase de type 1"

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van Horck, Francis P. G., Emmanuelle Lavazais, Britta J. Eickholt, Wouter H. Moolenaar та Nullin Divecha. "Essential Role of Type Iα Phosphatidylinositol 4-Phosphate 5-Kinase in Neurite Remodeling". Current Biology 12, № 3 (2002): 241–45. http://dx.doi.org/10.1016/s0960-9822(01)00660-1.

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Shim, Hyeseok, Chuan Wu, Shivan Ramsamooj, et al. "Deletion of the gene Pip4k2c, a novel phosphatidylinositol kinase, results in hyperactivation of the immune system." Proceedings of the National Academy of Sciences 113, no. 27 (2016): 7596–601. http://dx.doi.org/10.1073/pnas.1600934113.

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Type 2 phosphatidylinositol-5-phosphate 4-kinase (PI5P4K) converts phosphatidylinositol-5-phosphate to phosphatidylinositol-4,5-bisphosphate. Mammals have three enzymes PI5P4Kα, PI5P4Kβ, and PI5P4Kγ, and these enzymes have been implicated in metabolic control, growth control, and a variety of stress responses. Here, we show that mice with germline deletion of type 2 phosphatidylinositol-5-phosphate 4-kinase gamma (Pip4k2c), the gene encoding PI5P4Kγ, appear normal in regard to growth and viability but have increased inflammation and T-cell activation as they age. Immune cell infiltrates increa
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Bridges, Dave, Jing-Tyan Ma, Sujin Park, Ken Inoki, Lois S. Weisman, and Alan R. Saltiel. "Phosphatidylinositol 3,5-bisphosphate plays a role in the activation and subcellular localization of mechanistic target of rapamycin 1." Molecular Biology of the Cell 23, no. 15 (2012): 2955–62. http://dx.doi.org/10.1091/mbc.e11-12-1034.

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The kinase complex mechanistic target of rapamycin 1 (mTORC1) plays an important role in controlling growth and metabolism. We report here that the stepwise formation of phosphatidylinositol 3-phosphate (PI(3)P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) regulates the cell type–specific activation and localization of mTORC1. PI(3)P formation depends on the class II phosphatidylinositol 3-kinase (PI3K) PI3K-C2α, as well as the class III PI3K Vps34, while PI(3,5)P2 requires the phosphatidylinositol-3-phosphate-5-kinase PIKFYVE. In this paper, we show that PIKFYVE and PI3K-C2α are nece
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Prasad, K. V., R. Kapeller, O. Janssen, et al. "Phosphatidylinositol (PI) 3-kinase and PI 4-kinase binding to the CD4-p56lck complex: the p56lck SH3 domain binds to PI 3-kinase but not PI 4-kinase." Molecular and Cellular Biology 13, no. 12 (1993): 7708–17. http://dx.doi.org/10.1128/mcb.13.12.7708-7717.1993.

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CD4 serves as a receptor for major histocompatibility complex class II antigens and as a receptor for the human immunodeficiency virus type 1 (HIV-1) viral coat protein gp120. It is coupled to the protein-tyrosine kinase p56lck, an interaction necessary for an optimal response of certain T cells to antigen. In addition to the protein-tyrosine kinase domain, p56lck possesses Src homology 2 and 3 (SH2 and SH3) domains as well as a unique N-terminal region. The mechanism by which p56lck generates intracellular signals is unclear, although it has the potential to interact with various downstream m
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Prasad, K. V., R. Kapeller, O. Janssen, et al. "Phosphatidylinositol (PI) 3-kinase and PI 4-kinase binding to the CD4-p56lck complex: the p56lck SH3 domain binds to PI 3-kinase but not PI 4-kinase." Molecular and Cellular Biology 13, no. 12 (1993): 7708–17. http://dx.doi.org/10.1128/mcb.13.12.7708.

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CD4 serves as a receptor for major histocompatibility complex class II antigens and as a receptor for the human immunodeficiency virus type 1 (HIV-1) viral coat protein gp120. It is coupled to the protein-tyrosine kinase p56lck, an interaction necessary for an optimal response of certain T cells to antigen. In addition to the protein-tyrosine kinase domain, p56lck possesses Src homology 2 and 3 (SH2 and SH3) domains as well as a unique N-terminal region. The mechanism by which p56lck generates intracellular signals is unclear, although it has the potential to interact with various downstream m
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Davis, J. N., C. O. Rock, M. Cheng, et al. "Complementation of growth factor receptor-dependent mitogenic signaling by a truncated type I phosphatidylinositol 4-phosphate 5-kinase." Molecular and Cellular Biology 17, no. 12 (1997): 7398–406. http://dx.doi.org/10.1128/mcb.17.12.7398.

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Substitution of phenylalanine for tyrosine at codon 809 (Y809F) of the human colony-stimulating factor 1 (CSF-1) receptor (CSF-1R) impairs ligand-stimulated tyrosine kinase activity, prevents induction of c-MYC and cyclin D1 genes, and blocks CSF-1-dependent progression through the G1 phase of the cell cycle. We devised an unbiased genetic screen to isolate genes that restore the ability of CSF-1 to stimulate growth in cells that express mutant CSF-1R (Y809F). This screen led us to identify a truncated form of the murine type Ibeta phosphatidylinositol 4-phosphate 5-kinase (mPIP5K-Ibeta). This
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Demian, Douglas J., Susan L. Clugston, Meta M. Foster, et al. "High-Throughput, Cell-Free, Liposome-Based Approach for Assessing In Vitro Activity of Lipid Kinases." Journal of Biomolecular Screening 14, no. 7 (2009): 838–44. http://dx.doi.org/10.1177/1087057109339205.

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Lipid kinases are central players in lipid signaling pathways involved in inflammation, tumorigenesis, and metabolic syndrome. A number of these kinase targets have proven difficult to investigate in higher throughput cell-free assay systems. This challenge is partially due to specific substrate interaction requirements for several of the lipid kinase family members and the resulting incompatibility of these substrates with most established, homogeneous assay formats. Traditional, cell-free in vitro investigational methods for members of the lipid kinase family typically involve substrate inco
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Huang, Luofei, Han Li, and Quanzhi Lin. "Identification of key genes and diagnostic biomarkers for peripheral atherosclerosis: A multi-omics approach." Medicine 104, no. 21 (2025): e42437. https://doi.org/10.1097/md.0000000000042437.

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Peripheral atherosclerosis (PAS), characterized by lipid plaque accumulation in arterial walls, significantly increases cardiovascular risk. This study aimed to identify molecular biomarkers and elucidate underlying mechanisms of PAS progression. We analyzed 2 gene expression omnibus datasets (GSE28829, GSE100927) to identify differentially expressed genes (P < .05, |log2FC| ≥ 0.585). Functional enrichment (Gene Ontology/Kyoto Encyclopedia of Genes and Genomes) and Mendelian randomization analyses were performed using genome-wide association study and expression quantitative trait loci data
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Yamamoto, Masaya, Mark Z. Chen, Ying-Jie Wang та ін. "Hypertonic Stress Increases Phosphatidylinositol 4,5-Bisphosphate Levels by Activating PIP5KIβ". Journal of Biological Chemistry 281, № 43 (2006): 32630–38. http://dx.doi.org/10.1074/jbc.m605928200.

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Hyperosmotic stress increases phosphoinositide levels, reorganizes the actin cytoskeleton, and induces multiple acute and adaptive physiological responses. Here we showed that phosphatidylinositol 4,5-bisphosphate (PIP2) level increased rapidly in HeLa cells during hypertonic treatment. Depletion of the human type I phosphatidylinositol 4-phosphate 5-kinase β isoform (PIP5KIβ) by RNA interference impaired both the PIP2 and actin cytoskeletal responses. PIP5KIβ was recruited to membranes and was activated by hypertonic stress through Ser/Thr dephosphorylation. Calyculin A, a protein phosphatase
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Gerber, Pehuén Pereyra, Mercedes Cabrini, Carolina Jancic, et al. "Rab27a controls HIV-1 assembly by regulating plasma membrane levels of phosphatidylinositol 4,5-bisphosphate." Journal of Cell Biology 209, no. 3 (2015): 435–52. http://dx.doi.org/10.1083/jcb.201409082.

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During the late stages of the HIV-1 replication cycle, the viral polyprotein Pr55Gag is recruited to the plasma membrane (PM), where it binds phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) and directs HIV-1 assembly. We show that Rab27a controls the trafficking of late endosomes carrying phosphatidylinositol 4-kinase type 2 α (PI4KIIα) toward the PM of CD4+ T cells. Hence, Rab27a promotes high levels of PM phosphatidylinositol 4-phosphate and the localized production of PI(4,5)P2, therefore controlling Pr55Gag membrane association. Rab27a also controls PI(4,5)P2 levels at the virus-containi
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Dissertations / Theses on the topic "Phosphatidylinositol-4-phosphate 5-kinase de type 1"

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Gonzales, Baptiste. "Etudes des facteurs cellulaires et lipidiques déterminant la localisation du site d'assemblage et de bourgeonnement du VIH-1." Electronic Thesis or Diss., Tours, 2019. http://www.theses.fr/2019TOUR3811.

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La formation des particules du VIH-1 résulte de l'assemblage des précurseurs Gag sur le feuillet interne de la membrane plasmique (MP) des cellules infectées. Les protéines Gag sont spécifiquement adressées à la MP grâce à des interactions entre le domaine MA et le PI(4,5)P2. Cette étude décrit le rôle des phosphadidylinosito1-4-phosphate 5-kinase de type 1 (PIP5K1alpha, beta et sigma) au cours des étapes tardives du VIH-1 dans le modèle celllulaire HeLa. Nous avons démontré que la PIP5K1alpha est l'enzyme principalement impliquée dans la production du PI(4,5P2. En suivant le trafic de Gag à l
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Shim, Hyeseok. "Biology of Type 2 Phosphatidylinositol-5-Phosphate 4-Kinase." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:23845419.

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Type 2 phosphatidylinositol-5-phosphate 4-kinase (PI5P4K) converts phosphatidylinositol-5-phosphate to phosphatidylinositol-4,5-bisphosphate. Mammals have three genes, PIP4K2A, PIP4K2B and PIP4K2C that encode the enzymes PI5P4Kα, PI5P4Kβ and PI5P4Kγ respectively. Studies in mice showed that PI5P4Kβ is a negative regulator of insulin signaling (Lamia et al., 2004) and that co-deletion of Pip4k2b and Trp53 resulted in synthetic embryonic lethality (Emerling et al., 2013). Also, deletion of two alleles of Pip4k2a and one allele of Pip4k2b suppressed the appearance of tumors in Trp53-/- mice. Thes
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Xia, Yang. "The localisation and regulation of phosphatidylinositol-4-phosphate 5-Kinase gamma splice variants and the discovery of a new mammalian splice variant, PIP5KIγ_v6". Thesis, University of Cambridge, 2011. https://www.repository.cam.ac.uk/handle/1810/240633.

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Type I PIP kinases (phosphatidylinositol 4-phosphate 5-kinases, PIP5Ks) catalyse the majority of cellular synthesis of PI(4,5)P2. To date, three mammalian isoforms (r1, r2, r3) have been found. PIP5KIr is subject to complex C-terminal splice variation, enhancing its transcriptional diversity through evolution and producing at least 5 known spliceoforms in the mammals. This study addresses several important questions. (1) Several remarkable differences have been discovered between the neuronal splice variant PIP5KIr_i3 and its close variant, Ir_i2, whose peptide lacks a 26-AA insert near its C-
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Carbonara, Chateen. "Type I phosphatidylinositol-4-phosphate 5-kinase I[gamma] interacts with E-cadherin to regulate cell-cell contact assembly." 2005. http://catalog.hathitrust.org/api/volumes/oclc/62206794.html.

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Thesis (M.S.)--University of Wisconsin--Madison, 2005.<br>Typescript. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 81-86).
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Burgess, Jason. "The Clathrin Adaptor AP-1 and Type II Phosphatidylinositol 4-Kinase are Required for Glue Granule Biogenesis in Drosophila." Thesis, 2012. http://hdl.handle.net/1807/33847.

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Regulated secretion of hormones, digestive enzymes and other biologically active molecules requires formation of secretory granules. However, the molecular machinery required for secretory granule biogenesis is incompletely understood. I used powerful genetic approaches available in the fruit fly Drosophila melanogaster to investigate the factors required for biogenesis of mucin-containing ‘glue granules,’ which form within epithelial cells of the third-instar larval salivary gland. I discovered that clathrin and the clathrin adaptor protein complex (AP-1), as well the enzyme type II phosphati
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Books on the topic "Phosphatidylinositol-4-phosphate 5-kinase de type 1"

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Bardin, Thomas, and Tilman Drüeke. Renal osteodystrophy. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0149.

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Renal osteodystrophy (ROD) is a term that encompasses the various consequences of chronic kidney disease (CKD) for the bone. It has been divided into several entities based on bone histomorphometry observations. ROD is accompanied by several abnormalities of mineral metabolism: abnormal levels of serum calcium, phosphorus, parathyroid hormone (PTH), vitamin D metabolites, alkaline phosphatases, fibroblast growth factor-23 (FGF-23) and klotho, which all have been identified as cardiovascular risk factors in patients with CKD. ROD can presently be schematically divided into three main types by h
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Book chapters on the topic "Phosphatidylinositol-4-phosphate 5-kinase de type 1"

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Clarke, Jonathan H., and Robin F. Irvine. "Phosphatidylinositol 5-Phosphate 4-Kinase." In Encyclopedia of Signaling Molecules. Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4614-6438-9_418-1.

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Donato, Dominique M., Steven K. Hanks, Kenneth A. Jacobson, et al. "Phosphatidylinositol 5-phosphate 4-kinase." In Encyclopedia of Signaling Molecules. Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4419-0461-4_418.

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Im, Yang Ju, Irena Brglez, Catherine Dieck, Imara Y. Perera, and Wendy F. Boss. "Phosphatidylinositol 4-Kinase and Phosphatidylinositol 4-Phosphate 5-Kinase Assays." In Methods in Molecular Biology. Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-401-2_15.

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Schomburg, Dietmar, and Dörte Stephan. "1-Phosphatidylinositol-4-phosphate 5-kinase." In Enzyme Handbook 13. Springer Berlin Heidelberg, 1997. http://dx.doi.org/10.1007/978-3-642-59176-1_178.

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Radif, Yassmeen, and Mark G. Waugh. "Phosphatidylinositol 4-Kinase Type II Alpha." In Encyclopedia of Signaling Molecules. Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4614-6438-9_101785-1.

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Halstead, Jonathan R., Mireille H. Snel, Sarah Meeuws, David R. Jones, and Nullin Divecha. "Assaying Endogenous Phosphatidylinositol-4-Phosphate 5-Kinase (PIP5K) Activities." In Methods in Molecular Biology. Humana Press, 2008. http://dx.doi.org/10.1007/978-1-60327-115-8_25.

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Nishimura, Taki. "A Real-Time Phosphatidylinositol 4-Phosphate 5-Kinase Assay Using Fluorescence Spectroscopy." In Methods in Molecular Biology. Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-1142-5_8.

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Davis, Mindy I., Atsuo T. Sasaki, and Anton Simeonov. "Method for Assaying the Lipid Kinase Phosphatidylinositol-5-phosphate 4-kinase α in Quantitative High-Throughput Screening (qHTS) Bioluminescent Format." In Methods in Molecular Biology. Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-3170-5_1.

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Gokhale, Avanti, Pearl V. Ryder, Stephanie A. Zlatic, and Victor Faundez. "Identification of the Interactome of a Palmitoylated Membrane Protein, Phosphatidylinositol 4-Kinase Type II Alpha." In Methods in Molecular Biology. Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-3170-5_4.

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Anderson, K. E., L. R. Stephens,, and P. T. Hawkins. "Phosphoinositide 3-kinases." In Signal Transduction. Oxford University PressOxford, 1999. http://dx.doi.org/10.1093/oso/9780199637218.003.0011.

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Abstract Phosphoinositide 3OH-kinases (PI3Ks) are enzymes which can phosphorylate one or more membrane inositol lipids in the 3-position of the inositol ring; in vitro they can make phosphoinositide(3)phosphate (PtdIns(3)P), phospho- inositide(3,4)bisphosphate (PtdIns(3,4)P2), and phosphoinositide(3,4,5)triphos- phate (PtdIns(3,4,5)P3) from phosphoinositide (Ptdlns), phosphoinositide(4) phosphate (PtdIns(4)P), and phosphoinositide(4,5)bisphosphate (Ptdlns(4,5) P2), respectively. The substrate specificity of PI3Ks in the intact cell is a matter of current debate, but most evidence suggests that
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Conference papers on the topic "Phosphatidylinositol-4-phosphate 5-kinase de type 1"

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Chang, Tallis Y., M. D. Ewbank, R. A. Vazquez, L. F. Warren, and P. R. Newman. "Nonlinear optical studies of semiorganic crystals." In OSA Annual Meeting. Optica Publishing Group, 1989. http://dx.doi.org/10.1364/oam.1989.mw1.

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We invoke the term semiorganic to describe a new class of nonlinear optical compounds composed of part organic and part inorganic constituents. The recently reported crystal 1-arginine phosphate (LAP) is one such material where organic 1-arginine molecules form cations and crystallize with inorganic phosphate anions.1 We present another type of semiorganic crystal where organic molecules attach as ligands to the inorganic metal salt. We have grown two semiorganic crystals: zinc tris (thiourea) sulfate [Zn(TU)3SO4]2 and (4-nitropyri- dine-N-oxide) mercury chloride [(NPO)HgCl2]. Good optical qua
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Visileanu, Emilia, Elena Perdum, Laurentiu Dinca, Adrian Salistean, Felicia Dondea, and Razvan Scarlat. "Advanced materials with infrared camouflage properties." In 15th International Conference on Applied Human Factors and Ergonomics (AHFE 2024). AHFE International, 2024. http://dx.doi.org/10.54941/ahfe1004910.

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Nowadays, textile materials with a protective role must ensure the body's defence against a multitude of threats and fulfil a variety of functional requirements. In particular, textile products intended for military applications require durability, resistance to ballistic threats and environmental conditions (eg, ultraviolet (UV) light, moisture, fire, heat and wind), comfort, etc. In addition, these materials must provide camouflage in various ambient conditions at a wide range of wavelengths in the electromagnetic spectrum such as the near-infrared (NIR) region (750–1200 nm) and far infrared
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Elbashir, Israa, Aisha Aisha Nasser J. M. Al-Saei, Paul Thornalley, and Naila Rabbani. "Evaluation of antiviral activity of Manuka honey against SARS-CoV-2." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2021. http://dx.doi.org/10.29117/quarfe.2021.0113.

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Background and aims: In 2020 a global pandemic was declared caused by the severe acute respiratory syndrome coronavirus (SARS-CoV-2). The pandemic is still ongoing and continues to cause considerable mortality and morbidity world-wide and new variants of the virus are emerging. Rapid development and rollout of vaccines for SARS-CoV-2 is in progress to counter the pandemic but has been tempered by the emergence of new SARS-CoV-2 variants, many of which exhibit reduced vaccine effectiveness. To date there is no approved antiviral treatment for coronavirus disease 2019 (COVID-19). Several studies
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Selby, K., M. Urbanak, D. Colbourne, et al. "Meeting the Lubrication Challenges of Heavy Duty Low Emission Diesel Engines." In World Tribology Congress III. ASMEDC, 2005. http://dx.doi.org/10.1115/wtc2005-63983.

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In recent years, legislative authorities in the US, Europe and Japan have steadily reduced engine exhaust emissions, i.e., carbon monoxide (CO), hydrocarbons (HC), sulphur, particulate matter (PM) and nitrogen oxides (NOx) to improve air quality. To meet these requirements engine manufacturers have had to make significant design changes and as a consequence new engine lubricant specifications from Industry bodies (ACEA, EMA, JAMA) and individual OEMs have had to be introduced to ensure adequate lubrication of these new engines. This has led to significant changes to heavy-duty diesel engine oi
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