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Journal articles on the topic 'Phosphine pyridine derivatives'

Author: Grafiati

Published: 24 April 2022

Last updated: 30 July 2025

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1

Telezhkin, A. A., P. A. Volkov, and K. O. Khrapova. "Nucleophilic substitution of hydrogen in pyridine and its derivatives by organophosphorus nucleophiles in the presence of electron-deficient acetylenes." Журнал органической химии 59, no. 10 (2023): 1269–300. http://dx.doi.org/10.31857/s0514749223100026.

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The review considers publications on a new easy functionalization of pyridinoids (pyridines, quinolines, isoquinolines, acridine, phenanthridine) by the electron-deficient acetylene (esters of acetylenecarboxylic acids, acylacetylenes, cyanoacetylenes)/P-nucleophile (phosphine chalcogenides, H -phosphonates) system. Particular attention is paid to the SN H reaction of regioselective cross-coupling of pyridines with secondary phosphine chalcogenides, initiated by acylacetylenes and leading to the formation of 4-chalcogenophosphorylpyridines. In these processes, acetylenes act as trimodal adjuva

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2

Radhakrishna, Latchupatula, Basvaraj S. Kote, Harish S. Kunchur, Madhusudan K. Pandey, Dipanjan Mondal, and Maravanji S. Balakrishna. "1,2,3-Triazole based ligands with phosphine and pyridine functionalities: synthesis, Pd^II and Pt^II chemistry and catalytic studies." Dalton Transactions 51, no. 14 (2022): 5480–93. http://dx.doi.org/10.1039/d2dt00112h.

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This paper describes the synthesis of pyridine- and phosphine appended triazole ligands and their PdII and PtII complexes. Palladium complexes showed excellent catalytic efficiency in the α-alkylation reaction of acetophenone derivatives with alcohols.

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3

Sharif, Muhammad, Khurram Shoaib, Shahzad Ahmed, et al. "Synthesis of functionalised fluorinated pyridine derivatives by site-selective Suzuki-Miyaura cross-coupling reactions of halogenated pyridines." Zeitschrift für Naturforschung B 72, no. 4 (2017): 263–79. http://dx.doi.org/10.1515/znb-2016-0213.

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AbstractThe Suzuki-Miyaura reaction of 2,6-dichloro-3-(trifluoromethyl)pyridine with 1 equiv of arylboronic acids resulted in site-selective formation of 2-aryl-6-chloro-3-(trifluoromethyl)pyridine. Due to electronic reasons, the reaction takes place at the sterically more hindered position. The selectivity was rationalised by DFT calculations. The one-pot reaction with two different arylboronic acids afforded 2,6-diaryl-3-(trifluoromethyl)pyridine containing two different aryl substituents. The reactions proceeded smoothly in the absence of phosphine ligands. In addition, Suzuki-Miyaura react

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4

El Abbouchi, Abdelmoula, Jamal Koubachi, Nabil El Brahmi, and Said El Kazzouli. "Direct arylation and Suzuki-Miyaura coupling of imidazo[1,2-a]pyridines catalyzed by (SIPr)Pd(allyl)Cl complex under microwave-irradiation." Mediterranean Journal of Chemistry 9, no. 5 (2019): 347–54. http://dx.doi.org/10.13171/mjc1911271124sek.

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A short and practical arylation of imidazo[1,2-a]pyridine and imidazole derivatives with aryl halides or aryl boronic acids as coupling partners was successfully carried out using phosphine-free (SIPr)Pd(allyl)Cl as the catalyst [SIPr: (N,N’-bis(2,6-diisopropylphenyl)-4,5-dihydroimidazol-2-ylidene)] ((SIPr)Pd(allyl)Cl complex). 3,6-disubstituted imidazo[1,2-a]pyridine and 5-substituted imidazole compounds were obtained in good to excellent yields in only 1h under microwave-assisted C-H arylation and Suzuki-Miyaura coupling reaction conditions.

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5

Volkov, Pavel A., Nina I. Ivanova, Anton A. Telezhkin, et al. "Synthesis and antimicrobial activity of new phosphorus-containing pyridine derivatives." Butlerov Communications 57, no. 1 (2019): 50–56. http://dx.doi.org/10.37952/roi-jbc-01/19-57-1-50.

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The directed synthesis of new pharmacophoric molecules is one of the urgent tasks of organic chemistry. A special place in this area is occupied by vital nitrogen-containing heterocycles and their derivatives, on the basis of which new promising precursors of drugs are created. For example, pyridinium salts are part of such well-known drugs as pyridoxine, mexidol and metadoxine. Phosphorus-containing pyridine derivatives, among which compounds with cytotoxic and antimicrobial properties have been identified, are also being actively studied now. Thus, the development of convenient approaches fo

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6

Oestreich, Martin, Dou Hong, Wenbin Mao, and Elisabeth Irran. "Enantioselective, Copper-Catalyzed Addition of Nucleophilic Silicon to Alkenyl-Substituted Phosphine Oxides." Synthesis 54, no. 08 (2021): 2049–56. http://dx.doi.org/10.1055/a-1701-7500.

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AbstractAn enantioselective β-silylation of α,β-unsaturated phosphine oxide derivatives using a silylboronic ester as the silicon pronucleophile is reported. The reaction is catalyzed by copper salts in the presence of chiral pyridine–oxazoline (PyOx) ligands. Good to high enantioselectivities (≤95% ee) are obtained for β-aryl-substituted acceptors whereas alkyl residues in the β-position led to a lower ee value for 1° and no reaction for 2° and 3°. The new method represents another way of accessing α-chiral silanes and complements the known β-borylation.

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7

Sánchez López, Nicolás, Erick Nuñez Bahena, Alexander D. Ryabov, Pierre Sutra, Alain Igau, and Ronan Le Lagadec. "Synthesis, Properties, and Electrochemistry of bis(iminophosphorane)pyridine Iron(II) Pincer Complexes." Inorganics 12, no. 4 (2024): 115. http://dx.doi.org/10.3390/inorganics12040115.

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Iron derivatives have emerged as valuable catalysts for a variety of transformations, as well as for biological and photophysical applications, and iminophosphorane can be considered an ideal ligand scaffold for modulating electronic and steric parameters in transition metal complexes. In this report, we aimed to synthesize dichloride and dibromide iron(II) complexes supported by symmetric bis(iminophosphorane)pyridine ligands, starting from readily available ferrous halides. The ease of synthesis of this class of ligands served to access several derivatives with distinct electronic and steric

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8

Poater, Albert, and Luigi Cavallo. "A comprehensive study of olefin metathesis catalyzed by Ru-based catalysts." Beilstein Journal of Organic Chemistry 11 (September 29, 2015): 1767–80. http://dx.doi.org/10.3762/bjoc.11.192.

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During a Ru-catalyzed reaction of an olefin with an alkylidene moiety that leads to a metallacycle intermediate, the cis insertion of the olefin can occur from two different directions, namely side and bottom with respect to the phosphine or N-heterocyclic ligand (NHC), depending on the first or second generation Grubbs catalyst. Here, DFT calculations unravel to which extent the bottom coordination of olefins with respect is favored over the side coordination through screening a wide range of catalysts, including first and second generation Grubbs catalysts as well as the subsequent Hoveyda d

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9

Nogueira, Thais Cristina Mendonça, Lucas dos Santos Cruz, Maria Cristina Lourenço, and Marcus Vinicius Nora de Souza. "Design, Synthesis and Anti-tuberculosis Activity of Hydrazones and N-acylhydrazones Containing Vitamin B6 and Different Heteroaromatic Nucleus." Letters in Drug Design & Discovery 16, no. 7 (2019): 792–98. http://dx.doi.org/10.2174/1570180815666180627122055.

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Background: The term vitamin B6 refers to a set of six compounds, pyridoxine,pyridoxal ,and pyridoxamine and their phosphorylated forms, among which pyridoxal 5´-phosphate (PLP) is the most important and active form acting as a critical cofactor. These compounds are very useful in medicinal chemistry because of their structure and functionalities and are also used in bioinorganic chemistry as ligands for complexation with metals. Methods: In this study, a series of hydrazones 1a-g and N-acylhydrazones 2a-f containing vitamin B6 have been synthesized from commercial pyridoxal hydrochloride and

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10

Holý, Antonín, and Ivan Rosenberg. "Synthesis of isomeric and enantiomeric O-phosphonylmethyl derivatives of 9-(2,3-dihydroxypropyl)adenine." Collection of Czechoslovak Chemical Communications 52, no. 11 (1987): 2775–91. http://dx.doi.org/10.1135/cccc19872775.

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Reaction of 9-(S)-(2,3-dihydroxypropyl)adenine (I) with chloromethanephosphonyl chloride (VII) in pyridine or triethyl phosphate, or with chloromethyl(pyridinio)phosphonate (IX) in pyridine, afforded a mixture of 2'-(IV) and 3'-O-chloromethanephosphonate (V) which were separated on anion exchange resin or alkylsilica gel. Treatment of compounds IV and V with aqueous alkaline hydroxide, followed by deionization, gave 9-(S)-(2-hydroxy-3-phosphonylmethoxypropyl)adenine (VI) and 9-(S)-(3-hydroxy-2-phosphonylmethoxypropyl)adenine (III) (HPMPA), respectively. The (R)- and (RS)-forms of III and VI we

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11

Perich, JW, PF Alewood, and RB Johns. "Synthesis of Casein-Related Peptides and Phosphopeptides. VIII. The Synthesis of Ser(P)-Containing Peptides by the Use of Z-Ser(PO3R2)-OH Derivatives." Australian Journal of Chemistry 44, no. 2 (1991): 253. http://dx.doi.org/10.1071/ch9910253.

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.The synthesis of five Z-Ser(PO3R2)-OH (R = phenyl, ethyl, methyl, benzyl, t-butyl) derivatives is described by a simple three-step synthetic procedure which features the use of either (A) diphenyl or dialkyl phosphorochloridate /pyridine or (B) dialkyl N,N-diethylphosphoramidite/1H-tetrazole-m-chloroperoxybenzoic acid for the phosphorylation of the serine hydroxy group. The benzyl phosphate derivative, Z-Ser(PO3Bzl2)-OH, was used in the benzyloxycarbonyl mode of peptide synthesis for the preparation of Z-Ser(PO3Bzl2)-Leu-OBzl and Z-Ser(PO3Bzl2)-Ser(PO3Bzl2)- OBzl which were deprotected by pal

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12

Mani, J. Arul Martin, M. Mercina, S. Antony Inglebert, P. Narayanan, V. Joseph та P. Sagayaraj. "Crystal structure determination of two pyridine derivatives: 4-[(E)-2-(4-methoxyphenyl)ethenyl]-1-methylpyridin-1-ium hexafluoro-λ6-phosphane and 4-[(E)-2-[4-(dimethylamino)phenyl]ethenyl]-1-phenyl-1λ5-pyridin-1-ylium hexafluoro-λ6-phosphane". Acta Crystallographica Section E Crystallographic Communications 75, № 2 (2019): 288–91. http://dx.doi.org/10.1107/s2056989019001403.

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The title molecular salts, C16H16NO+·PF6 −, (I), and C21H21N2 +·PF6 −, (II), are pyridine derivatives. In compound (I), the cation comprises a methyl N-substituted pyridine ring and a methoxy-substituted benzene ring connected by a C=C double bond. The F atoms of the PF6 − anion are disordered over two sets of sites with refined occupancy factors of 0.614 (7):0.386 (7). In compound (II), the cation comprises a pyridine ring attached to unsubstituted phenyl ring and a dimethylaniline ring, which are connected by a C=C double bond. The anion is PF6 −. In both salts, the cation adopts an E config

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13

Perich, JW, PF Alewood, and RB Johns. "Synthesis of Casein-Related Peptides and Phosphopeptides. VII. The Efficient Synthesis of Ser(P)-Containing Peptides by the Use of Boc-Ser(PO3R2)-OH Derivatives." Australian Journal of Chemistry 44, no. 2 (1991): 233. http://dx.doi.org/10.1071/ch9910233.

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A new approach to the synthesis of Ser(PO3R2)-containing peptides by using five protected Boc-Ser(PO3R2)-OH (R=phenyl, ethyl, methyl, benzyl, t-butyl) derivatives is described. The five Boc-protected derivatives are prepared by a simple three-step synthetic procedure which features the use of either (A) diphenyl or dialkyl phosphorochloridate/pyridine, or (B) dialkyl N,N-diethylphosphoramidite/1H-tetrazole-m-chloroperoxybenzoic acid for the phosphorylation of the serine hydroxy group. The five derivatives were utilized in the Boc mode of peptide synthesis with the use of the mixed-anhydride co

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14

Çaylı, Gökhan, Cengiz Kahraman, and Mustafa Güler. "Synthesis, Characterization, and Evaluation of Anion Removal Properties of Cationic Derivatives of Waste Triglycerides." EJONS International Journal on Mathematic, Engineering and Natural Sciences 8, no. 4 (2024): 504–15. https://doi.org/10.5281/zenodo.14327108.

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Waste cooking oils (WCO) exert a detrimental effect on the environment. It is crucial for our future to either reuse or eliminate those materials. This study assesses the cationic derivatives of triglycerides derived from plant oils. Furthermore, the research also examines the potential of the synthesized materials to remove anions. The process of creating cationic derivatives involves three distinct phases. The initial procedure involves the epoxidation of the utilized cooking oil (WCO). The next procedure involves the amalgamation of epoxidized waste cooking oil (EWO) with monochloroacetic a

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15

Tyunina, Elena Yu, Olga N. Krutova, and Alexandr I. Lytkin. "COMPARISON OF L-ASPARAGINE INTERACTIONS WITH PYRIDINE DERIVATIVES, PYRIDOXAL- 5'-PHOSPHATE AND PYRIDOXINE, IN AQUEOUS SOLUTIONS: THERMODYNAMIC ASPECTS." IZVESTIYA VYSSHIKH UCHEBNYKH ZAVEDENII KHIMIYA KHIMICHESKAYA TEKHNOLOGIYA 64, no. 5 (2021): 12–18. http://dx.doi.org/10.6060/ivkkt.20216405.6373.

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Interactions of proteins with various biologically active substances (hormones, drugs, enzymes, etc.) underlie many biochemical processes in the body. As part of the long-term task to studying various aspects of the interaction between model protein compounds and heterocyclic compounds that are into the structure of many enzymes and drugs, the thermochemical study of aqueous solutions containing aspartic acid amide (L-asparagine) and peridoxal-5¢-phosphate was carried out. Calorimetric measurements of the enthalpy of L-asparagine dissolution in an aqueous solution with pyridoxal-5¢-phosphate a

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16

Herberhold, Max, Gudrun Frohmader, Jürgen Peukert та Wolfgang Milius. "Monosubstituierte Derivate des Halbsandwich-Komplexes Cp*Ta(CO)4 - Vergleich mit den analogen Vanadiumverbindungen Cp*V(CO)3L und Röntgenstrukturanalyse des γ-Picolin-Komplexes Cp*V(CO)3(NC5H4-Me(4)) / Monosubstituted Derivatives of the Halfsandwich Complex Cp*Ta(CO)4 - Comparison with the Analogous Vanadium Compounds Cp*V(CO)3L and X-Ray Structural Analysis of the γ-Picoline Complex Cp*V(CO)3(NC5H4-Me(4))". Zeitschrift für Naturforschung B 55, № 12 (2000): 1188–94. http://dx.doi.org/10.1515/znb-2000-1212.

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The photo-induced substitution of a CO ligand in Cp*Ta(CO)4 (1) has been used to prepare a series of Cp*Ta(CO)3L (2) complexes, in which the two-electron ligand L includes, e.g., isonitriles, sulfanes, cyclic ethers, phosphanes and pyridines. The complexes (2a-y) were characterized by their v(CO) frequencies and their 1H and 13C NMR spectra, and were compared - if possible - with the corresponding vanadium complex, Cp*V(CO)4 (3) and its derivatives, Cp*V(CO)3L (4). The molecular structure of the 4-picoline complex Cp*V(CO)3(NC5H4-Me(4)) (4r) has been determined by X-ray crystal structure analy

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17

Sharif, Shasad, Douglas R. Powell, David Schagen, et al. "X-ray crystallographic structures of enamine and amine Schiff bases of pyridoxal and its 1:1 hydrogen-bonded complexes with benzoic acid derivatives: evidence for coupled inter- and intramolecular proton transfer." Acta Crystallographica Section B Structural Science 62, no. 3 (2006): 480–87. http://dx.doi.org/10.1107/s0108768105040590.

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Crystal structures of Schiff bases containing pyridoxal (PL), N-(pyridoxylidene)-tolylamine, C15H16N2O2 (I), N-(pyridoxylidene)-methylamine, C9H12N2O2 (III), and their 1:1 adduct with 2-nitrobenzoic acid, (I)+ C7H4NO_4^- (II), and 4-nitrobenzoic acid, (III)+ C7H4NO_4^- (IV), serve as models for the coenzyme pyridoxal-5′-phosphate (PLP) in its PLP-dependent enzymes. These models allow the study of the intramolecular OHN hydrogen bond of PL/PLP Schiff bases and the H-acceptor properties of their pyridine rings. The free base (I) forms hydrogen-bonded chains involving the hydroxyl side groups and

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18

Roustan, Jean-Louis, Nasrin Ansari, Yvon Le Page, and Jean-Pierre Charland. "Molecular geometry of M(NO)2 complexes: single crystal X-ray structure of Co(NO)2(C5H5N)2+BF4−, lability of the pyridine ligands of Co(NO)2(C5H5N)2+, and its relevance to the formation of the Co2(NO)3+ bimetallic core." Canadian Journal of Chemistry 70, no. 6 (1992): 1650–57. http://dx.doi.org/10.1139/v92-206.

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The BPh4− and BF4− derivatives of Co(NO)2(Py)2+3 (Py = pyridine) have been prepared. In solution, whereas Co(NO)2(L)2+BPh4− (L = phosphane) and 3-BF4− are inert, 3-BPh4− decomposes rapidly in the absence of an excess of Py. Complex 3-BF4− crystallizes in the monoclinic system with two independent molecules, A and B, in the asymmetric unit, space group P21/a, a = 14.7633(6) Å, b = 13.9739(5) Å, c = 15.1667(6) Å, β = 109.334(4)°, 2225 reflections, R = 0.054, Rw = 0.023. The cobalt coordination polyhedron is a distorted tetrahedron. The comparison of the (O)N—Co—N(O) angles of 115.6(3)° (molecule

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19

Minakov, Denis Viktorovich, Elena Yur'yevna Egorova, Vadim Ivanovich Markin, and Natal'ya Grigor'yevna Bazarnova. "PROSPECTS FOR MODIFYING THE STRUCTURE OF CHITIN AND CHITOSAN OF HIGHER FUNGI TO EXPAND THE POTENTIAL OF THEIR APPLIED USE." chemistry of plant raw material, no. 4 (December 15, 2023): 29–52. http://dx.doi.org/10.14258/jcprm.20230413381.

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The review is devoted to summarizing scientific data in the field of the chemical structure and properties of chitin and chitosan obtained from fungal biomass, and to analyzing directions for their modification for use in medicine and the food industry as substances with antibacterial, antiviral, wound-healing and anticoagulant activity. The features of chitin biosynthesis by fungi of the Basidiomycota, Ascomycota, Deuteromycota departments and chitosan biosynthesis by fungi of the Zygomycota department are covered. It has been shown that higher fungi contain chitin in their cell walls in the

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20

Desantis, Jenny, Serena Massari, Alice Sosic, et al. "Design and Synthesis of WM5 Analogues as HIV-1 TAR RNA Binders." Open Medicinal Chemistry Journal 13, no. 1 (2019): 16–28. http://dx.doi.org/10.2174/1874104501913010016.

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Background: The 6-aminoquinolone WM5, previously identified by us, is among the most selective small molecules known as TAR RNA binders to show anti-HIV activity. Methods: Starting from WM5, a series of analogues modified at N-1, C-6 or C-7 position was prepared by inserting guanidine or amidine groups as well as other protonable moieties intended to electrostatically bind the phosphate backbone of TAR. All the compounds were tested for their ability to inhibit HIV-1 replication in MT-4 cells and in parallel for their cytotoxicity. The active compounds were also evaluated for their ability to

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21

Pavaloiu, Ramona-Daniela, Fawzia Sha At, Mihaela Eremia, et al. "Formulation and Characterisation of Pullulan Acetate Nanoparticles Loaded with 5-Fluorouracil." Materiale Plastice 59, no. 2 (2022): 138–44. http://dx.doi.org/10.37358/mp.22.2.5593.

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This study was geared to analyze the preparation methods of pullulan acetate-based nanoparticles loaded with 5-fluorouracil, as well as the potential of pullulan as a biopolymer matrix for obtaining nanoparticles applied in the delivery of anticancer drugs (5-FU). Various methods were used to produce pullulan acetate-based nanoparticles loaded with 5-FU, including nanoprecipitation, modified nanoprecipitation, and double emulsion. Pullulan was previously chemically modified with acetic anhydride, dimethylformamide and pyridine, and yielded pullulan acetate. Pullulan was made using the Aureobas

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22

Kufelnicki, Aleksander, Mirosława Świątek, Magdalena Woźniczka, Urszula Kalinowska-Lis, Julia Jezierska, and Justyn Ochocki. "Complexing Properties of Pyridine-4-methylene Derivatives: Diethyl(pyridine-4-ylmethyl)phosphate, 4-Pyridylmethylphosphonic Acid and 4-Hydroxymethylpyridine with Cu(II) in Aqueous Solution." Journal of Solution Chemistry 45, no. 1 (2016): 28–41. http://dx.doi.org/10.1007/s10953-015-0424-z.

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23

Yang, Da, Huan Liu, Dong-Liang Wang, Yong Lu, Xiao-Li Zhao, and Ye Liu. "Au-complex containing phosphino and imidazolyl moieties as a bi-functional catalyst for one-pot synthesis of pyridine derivatives." Journal of Molecular Catalysis A: Chemical 424 (December 2016): 323–30. http://dx.doi.org/10.1016/j.molcata.2016.09.008.

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24

Wang, Xudong, Gail J. Mick, Edmund Maser та Kenneth McCormick. "Manifold effects of palmitoylcarnitine on endoplasmic reticulum metabolism: 11β-hydroxysteroid dehydrogenase 1, flux through hexose-6-phosphate dehydrogenase and NADPH concentration". Biochemical Journal 437, № 1 (2011): 109–15. http://dx.doi.org/10.1042/bj20102069.

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With the exception of the oxidation of G6P (glucose 6-phosphate) by H6PDH (hexose-6-phosphate dehydrogenase), scant information is available about other endogenous substrates affecting the redox state or the regulation of key enzymes which govern the ratio of the pyridine nucleotide NADPH/NADP. In isolated rat liver microsomes, NADPH production was increased, as anticipated, by G6P; however, this was strikingly amplified by palmitoylcarnitine. Subsequent experiments revealed that the latter compound, well within its physiological concentration range, inhibited 11β-HSD1 (11β-hydroxysteroid dehy

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Rabe, Gerd W., Ilia A. Guzei, and Arnold L. Rheingold. "Monomeric versus dimeric arrangement in the solid-state structures of pyridine adducts of lithium derivatives of two primary phosphanes." Inorganica Chimica Acta 315, no. 2 (2001): 254–57. http://dx.doi.org/10.1016/s0020-1693(01)00359-0.

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Kalinowska-Lis, Urszula, Eligia M. Szewczyk, Lilianna Chęcińska, Jakub M. Wojciechowski, Wojciech M. Wolf, and Justyn Ochocki. "Synthesis, Characterization, and Antimicrobial Activity of Silver(I) and Copper(II) Complexes of Phosphate Derivatives of Pyridine And Benzimidazole." ChemMedChem 9, no. 1 (2013): 169–76. http://dx.doi.org/10.1002/cmdc.201300333.

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VURAL, Derya, and Selbi KESKİN. "Synthesis and Spectroscopic Characterization of Novel Pyridine-based N-acyl Hydrazone Derivatives and Molecular Docking Studies on Glucosamine-6-Phosphate." Karadeniz Fen Bilimleri Dergisi 13, no. 1 (2023): 135–52. http://dx.doi.org/10.31466/kfbd.1184337.

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Antimicrobial resistance in infectious diseases caused by organisms such as bacteria, fungi, viruses, and parasites has led to an increase in studies and demands for new antimicrobial drug development. The compounds including pyridine and N-acylhydrazone skeletons in their structures have a large application area in drug discovery due to their anticancer, anti-tubercular, anti-bacterial and anti-fungal activities. Here, the novel N-acyl-hydrazone derivatives, (E)-2-oxo-N'-(2,3,4-trimethoxybenzylidene)-1,2-dihydropyridine-3-carbohydrazide and (E)-N'-(1-(4-bromophenyl) ethylidene)-2-oxo-1,2-dihy

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Nguyen, Dinh Luyen, Van Giang Nguyen, Thi Bich Van Nong, Thi Hien Pham, and Van Hai Nguyen. "ID1056 Synthesis and biological evaluation of novel curcumin derivative with water-soluble phosphate group as potential antitumor agent." Biomedical Research and Therapy 4, S (2017): 138. http://dx.doi.org/10.15419/bmrat.v4is.331.

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Background: Curcumin (diferuloylmethane) is the main natural active polyphenol from the rhizome of Curcuma longa (turmeric) and in others Curcuma spp. The main pharmacological effects include anti-tumor, anti-inflammatory, anti-oxidation, anti-fungal and anti-bacterial activities. However, the clinical application of curcumin is limited by its main drawbacks such as low solubility, poor bioavailability and rapid excretion from the body. In this study, the chemical modification approach was performed to improve the solubility of curcumin in water, at the same time increase the anti-tumor activi

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Grewal, Ajmer S., Viney Lather, Neha Charaya, Neelam Sharma, Sukhbir Singh, and Visvaldas Kairys. "Recent Developments in Medicinal Chemistry of Allosteric Activators of Human Glucokinase for Type 2 Diabetes Mellitus Therapeutics." Current Pharmaceutical Design 26, no. 21 (2020): 2510–52. http://dx.doi.org/10.2174/1381612826666200414163148.

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Background: Glucokinase (GK), a cytoplasmic enzyme catalyzes the metabolism of glucose to glucose- 6-phosphate with the help of ATP and aids in the controlling of blood glucose levels within the normal range in humans. In pancreatic β-cells, it plays a chief role by controlling the glucose-stimulated secretion of insulin and in liver hepatocyte cells, it controls the metabolism of carbohydrates. GK acts as a promising drug target for the pharmacological treatment of patients with type 2 diabetes mellitus (T2DM) as it plays an important role in the control of carbohydrate metabolism. Methods: D

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Palacios, Francisco, Domitila Aparicio, Jesús García, Javier Vicario та José María Ezpeleta. "Regioselective Alkylation Reactions of Enamines Derived from Phosphane Oxides − Synthesis of Phosphorus Substituted Enamino Esters, δ-Amino-phosphonates, Pyridone Derivatives and Pyrroles". European Journal of Organic Chemistry 2001, № 17 (2001): 3357. http://dx.doi.org/10.1002/1099-0690(200109)2001:17<3357::aid-ejoc3357>3.0.co;2-j.

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Granifo, Juan, Mois�s E. Vargas, Elaine S. Dodsworth, David H. Farrar, Scott S. Fielder, and A. B. P. Lever. "Mono- and di-nuclear complexes of molybdenum carbonyl derivatives with pyridine-2-carbaldehyde azine and phosphines: syntheses, structure, spectroscopic and electrochemical characterisation and solvatochromic effects." Journal of the Chemical Society, Dalton Transactions, no. 23 (1996): 4369. http://dx.doi.org/10.1039/dt9960004369.

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32

Wang, Yixuan, Yun Chen, Hongxu Du, et al. "Comparison of the anti-duck hepatitis A virus activities of phosphorylated and sulfated Astragalus polysaccharides." Experimental Biology and Medicine 242, no. 3 (2016): 344–53. http://dx.doi.org/10.1177/1535370216672750.

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Duck hepatitis A virus (DHAV) (Picornaviridae) causes an infectious disease in ducks which results in severe losses in duck industry. However, the proper antiviral supportive drugs for this disease have not been discovered. Polysaccharide is the main ingredient of Astragalus that has been demonstrated to directly and indirectly inhibit RNA of viruses replication. In this study, the antiviral activities of Astragalus polysaccharide (APS) and its derivatives against DHAV were evaluated and compared. APS was modified via the sodium trimetaphosphate and sodium tripolyphosphate (STMP-STPP) method a

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33

Palacios, Francisco, Domitila Aparicio, Jesus Garcia, Javier Vicario та Jose Maria Ezpeleta. "ChemInform Abstract: Regioselective Alkylation Reactions of Enamines Derived from Phosphane Oxides - Synthesis of Phosphorus Substituted Enamino Esters, δ-Amino-phosphonates, Pyridone Derivatives and Pyrroles." ChemInform 33, № 17 (2010): no. http://dx.doi.org/10.1002/chin.200217172.

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34

Krechl, Jiří, Daniela Mižaninová, Jiří Volke, and Josef Kuthan. "Polarographic reduction of p–substituted 1-phenyl-3-aminocarbonylpyridinium salts." Collection of Czechoslovak Chemical Communications 52, no. 6 (1987): 1550–60. http://dx.doi.org/10.1135/cccc19871550.

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The substitution effect of different groups (H, NO2, COOH, Br, Cl, NHCOCH3, CH3, OCH3, OH, and N(C2H5)2) on the polarographic behaviour of p–substituted 1-phenyl-3-aminocarbonylpyridinium cations has been investigated, in particular on their half-wave potentials in aqueous phosphate buffers pH 6·65 (10% DMF) and in anhydrous solutions of dimethylformamide with 0·05 mol l-1 (n-C4H9)4N+BF4- as supporting electrolyte. The half-wave potentials of the reduction wave which corresponds to the uptake of a single electron (wave B) and to the formation of the primary radical, obey a Hammett correlation

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35

De Wolf, Marc J. S., Guido A. F. Van Dessel, Albert R. Lagrou, Herwig J. J. Hilderson, and Wilfried S. H. Dierick. "Topography, purification and characterization of thyroidal NAD+ glycohydrolase." Biochemical Journal 226, no. 2 (1985): 415–27. http://dx.doi.org/10.1042/bj2260415.

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Subcellular fractionation of bovine thyroid tissue by differential pelleting and isopycnic gradient centrifugation in a zonal rotor indicated that NAD+ glycohydrolase is predominantly located and rather uniformly distributed in the plasma membrane. Comparison of NAD+ glycohydrolase activities of intact thyroid tissue slices, functional rat thyroid cells in culture (FRTl) and their respective homogenates indicated that most if not all of the enzyme (catalytic site) is accessible to extracellular NAD+. The reaction product nicotinamide was predominantly recovered from the extracellular medium. T

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Oluwalana, Damilola, Kelli Hartman, Raisa Krutilina, et al. "Abstract PO3-06-13: A novel stable 6-aryl-2-benzoyl-pyridine colchicine-binding site inhibitor targeting microtubules (60c) is effective against taxane-resistant, metastatic breast cancer." Cancer Research 84, no. 9_Supplement (2024): PO3–06–13—PO3–06–13. http://dx.doi.org/10.1158/1538-7445.sabcs23-po3-06-13.

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Abstract Background: Improving survival for patients diagnosed with metastatic disease and treating spontaneous chemoresistance remain major clinical challenges in treating breast cancer. Triple negative breast cancer (TNBC), characterized by a lack of therapeutically targetable receptors (ER/PR/HER2), is an aggressive subtype of breast cancer. TNBC therapy relies on a combination of systemically administered chemotherapies, including microtubule-targeting agents (MTAs) like paclitaxel (taxane class) or eribulin (vinca class); however, there are currently no FDA approved MTAs that bind to the

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del Rı́o, Ignacio, Robert A. Gossage, Martin Lutz, Anthony L. Spek та Gerard van Koten. "Reactivity of a binuclear Ru(II) N2-bridged complex towards phosphines: facile access to novel mono and binuclear phosphorous derivatives. X-ray structural characterization of two unusual binuclear complexes containing ‘pincer’ ligands: [{RuCl2(η3-NN′N)}2(μ-η2-P2)] (NN′N=2,6-bis[(dimethylamino)methyl]pyridine; P2=1,3-bis[(diphenylphosphino)methyl]benzene or 1,3-bis(diphenylphosphino)propane)". Journal of Organometallic Chemistry 583, № 1-2 (1999): 69–79. http://dx.doi.org/10.1016/s0022-328x(99)00105-9.

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Mohite, Manali, Sonu Sheokand, Dipanjan Mondal, and Maravanji Shivaramaiah Balakrishna. "Catalytic utility of PNN based MnI pincer complexes in the synthesis of quinolines and transfer hydrogenation of carbonyl derivatives." Dalton Transactions, 2024. http://dx.doi.org/10.1039/d4dt00001c.

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This manuscript describes the synthesis of a triazolyl-pyridine based phosphine, N-((diphenylphosphaneyl)methyl)-N-methyl-6-(1-phenyl-1H-1,2,3-triazol-4-yl)pyridin-2-amine, [2,6-{(PPh2)CH2N(Me)(C5H3N)(C2HN3C6H5)}] (1) (here onwards referred to as PNN) and its cationic and neutral MnI complexes and catalytic applications. The...

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Sakamoto, Kana, and Takahiro Nishimura. "Asymmetric addition of an N-methyl C(sp³)–H bond to cyclic alkenes enabled by an iridium/phosphine-olefin catalyst." Chemical Communications, 2022. http://dx.doi.org/10.1039/d2cc04642c.

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Iridium-catalyzed asymmetric C–H addition of an N-methy group on 3-trifluoromethyl-2-(N-methylamino)pyridine to cyclic alkenes was realized by using a phosphine-olefin ligand. Indene and its 7-substituted derivatives, acenaphthylene, and some bicyclic alkenes...

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Canac, Yves, Jérémy Willot, Sana Fatima, Carine Duhayon, Noël Lugan, and Dmitry A. Valyaev. "Manganese‐Mediated Synthesis of NHC‐Phosphine Ligand Precursors." Helvetica Chimica Acta, March 5, 2024. http://dx.doi.org/10.1002/hlca.202400009.

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Alkylation of N‐substituted imidazoles ImR’ (R’ = 2,4,6‐trimethylphenyl, 2,6‐diisopropylphenyl, 1‐adamantyl) with Mn(I) methylenephosphonium complexes [Cp(CO)2Mn(η2‐P,C‐R2P=C(H)Ph)](BF4) (PR2 = PPh2, PCy2, trans‐PC(H)PhCH2CH2C(H)Ph) followed by photochemical demetallation afforded a series of bidentate NHC‐phosphine ligand precursors [R2PC(H)PhImR’](BF4) in moderate to good yield. The same strategy was successfully applied to N‐functionalized imidazoles ImL (L = 2‐pyridyl, CH2SMe, CH2ImMe) to afford selectively NHC core pincer pre‐ligands featuring phosphine/thioether, phosphine/NHC and phosph

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Jaeger, Ruben, Simon Rachor, Mike Ahrens, and Thomas Braun. "Activation of SO2F2 at a Rhodium PNP Pincer Complex: Ligand Supported S‐F Bond Cleavage to Generate NSO2F Derivatives." Chemistry – A European Journal, May 17, 2024. http://dx.doi.org/10.1002/chem.202401571.

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The κ2‐(P,N)‐phosphine ligand precursor NH(CH2CH2PCy2)2 can be used for the synthesis of the rhodium(I) complex [Rh(CO){ĸ3‐(P,N,P)‐Cy2PC2H4NHC2H4PCy2}][Cl] (1). The deprotonated complex [Rh(CO){ĸ3‐(P,N,P)‐Cy2PC2H4NC2H4PCy2}] (2) shows a cooperative reactivity of the PNP ligand in the activation reaction of SO2F2 to yield the rhodium fluorido complex trans‐[Rh(F)(CO){ĸ2‐(P,P)‐Cy2PC2H4N(SO2F)C2H4PCy2}]2 (3) by S‐F bond cleavage. It is remarkable that no reaction was observed when 3 was treated with hydrogen sources e.g. dihydrogen, organosilicon compounds such as triethylsilane or TMS‐CF3 and di

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Wani, Aabid, Juan José Gamboa Carballo, Harikrishnan Jayaprakash, et al. "A Simple Manganese(I) Catalyst for the Efficient and Selective Hydrophosphination of Olefins with PH3, Primary, and Secondary Phosphanes." Chemistry – A European Journal, February 5, 2024. http://dx.doi.org/10.1002/chem.202303848.

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A tridentate ligand L with a P,NH,N donor motif was synthesized in few steps from commercially available precursors. Upon reaction with [MnBr(CO)5], an octahedral 18‐electron complex [Mn(CO)3(L)]Br (1) is obtained in which L adopts a facial arrangement. Deprotonation of the NH group leads under loss of CO to a neutral Mn(I) amide complex [Mn(CO)2(L‐H)] (2), which has a trigonal bipyramidal structure with the P and N donor centers are in trans position. Further deprotonation of 2 gives the deep‐blue anion [Mn(CO)2(L‐2H)]‐ (3). DFT calculations and QTAIM analyses show that 2 contains a Mn–N bond

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"Novel diphenylphosphine derivatives of 2,2′-bithiophene, 2,2′:5′,2″-terthiophene, 2-(2′-thienyl)pyridine and 2,6-di-2′-thienylpyridine. Crystal structures of 5,5′-bis(diphenylphosphino)-2,2′-bithiophene, diphenyl{5-[6′-(diphenylphosphino)-2′-pyridyl]-2-thienyl}phosphine and 2,6-bis[5′-(diphenylphosphino)-2′-thienyl]pyridine." Journal of the Chemical Society, Perkin Transactions 1, no. 24 (November 19, 2001): 3352–60. http://dx.doi.org/10.1039/b107389n.

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44

Wang, Zhan-Yong, Qi Guo, Shaohong Xu, and Kai-Kai Wang. "Nucleophilic H-phosphites, H-phosphinates and H-phosphine oxides in organic reactions." Synthesis, May 18, 2021. http://dx.doi.org/10.1055/a-1511-0382.

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P(O)-H compounds like H-phosphites, H-phosphinates and H-phosphine oxides are widely used as nucleophiles. Herein, reactions with unsaturated compounds, C-H activation, Hiro reaction, P-C, P-S, P-O, P-N and P-F couplings were thoroughly discussed and summarized. This review will focus on their reactions with alkenes, alkynes, enamides, propiolic acids, epoxide, arynes, arenes, quinones, isothiocyanates, diazo compounds, aldehydes, ketones, imines, pyridines, acid derivatives, carbocations, aryl halides, dibromoalkenes, disulfides, thiosulfates, sulfonyl chlorides, iodonium salts, amines, alcoh

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EL HALLAOUI, Achraf, Youssef Merroun, Soukaina CHEHAB, et al. "Efficient Synthesis of Symmetrically Substituted Pyridines and Substituted Alkene through Green and Heterogeneous Catalysis with Zinc Phosphate." Organic & Biomolecular Chemistry, 2023. http://dx.doi.org/10.1039/d3ob00634d.

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This study presents a new environmentally sustainable catalytic method for the synthesis of symmetrically substituted pyridine derivatives and substituted alkenes, using zinc phosphate (Zn3(PO4)2.4H2O) as a non-toxic and green heterogeneous...

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46

Zhang, Juan, Haiyan Zhang, Zhen Wang, and Weijun Yao. "Concise Synthesis of Tetra-substituted 1,6-Dihydropyridazine and Pyridazine derivatives." Synthesis, October 17, 2024. http://dx.doi.org/10.1055/a-2445-1338.

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We have developed a novel one pot three steps process, including phosphine catalyzed Rauhut−Currier reaction of γ-alkyl allenoate, Diels-Alder reaction with di-tert-butyl azodicarboxylate and followed by deprotection of Boc group, to prepared tetra-substituted 1,6-dihydropyridazine in good yield. The 1,6-dihydropyridazine was easily converted to pyridazine derivatives via oxidative aromatization by DDQ.

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47

Ibragimova, Regina, Qiu-Lin Lu, Mei-Xiang Wang, Jieping Zhu, and Shuo Tong. "Asymmetric Synthesis of Inherently Chiral Tetraoxacalix[2]arene[2]pyridines via SNAr‐based Cross‐cyclotetramerization." Chemistry – An Asian Journal, January 29, 2025. https://doi.org/10.1002/asia.202401621.

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Potassium phosphate‐promoted cross‐cyclotetramerization of 2,6‐dichloro‐3‐nitropyridine 1 with resorcinol derivatives 2 gave rise to thermodynamically favored 1,3‐alternate tetraoxacalix[2]arene[2]pyridines and kinetically controlled 1,2‐alternate isomers. The kinetic product could convert into its 1,3‐alternate conformational isomer by a macrocycle to macrocycle conversion pathway. Enantiomerically enriched C2‐symmetric inherently chiral tetraoxacalix[2]arene[2]pyridines were synthesized via a Cinchonine‐derived chiral phase‐transfer catalyst (PTC). This synthesis involved the cross‐cyclotetr

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Wang, Haixia, Xiaoyu Wang, Hao Ren, Xuejun Wang, and Zhenmei Lu. "3-Hydroxypyridine Dehydrogenase HpdA Is Encoded by a Novel Four-Component Gene Cluster and Catalyzes the First Step of 3-Hydroxypyridine Catabolism in Ensifer adhaerens HP1." Applied and Environmental Microbiology 86, no. 19 (2020). http://dx.doi.org/10.1128/aem.01313-20.

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ABSTRACT 3-Hydroxypyridine (3HP) is an important natural pyridine derivative. Ensifer adhaerens HP1 can utilize 3HP as its sole sources of carbon, nitrogen, and energy to grow, but the genes responsible for the degradation of 3HP remain unknown. In this study, we predicted that a gene cluster, designated 3hpd, might be responsible for the degradation of 3HP. The analysis showed that the initial hydroxylation of 3HP in E. adhaerens HP1 was catalyzed by a four-component dehydrogenase (HpdA1A2A3A4) and led to the formation of 2,5-dihydroxypyridine (2,5-DHP). In addition, the SRPBCC component in H

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Schneider, Tobias, Kai Schwedtmann, Jannis Fidelius, Rosa M. Gomila, Antonio Frontera, and Jan J. Weigand. "Synthesis of Diaryl‐ and Dialkynylphosphinates From Ubiquitous P^V Sources via a Redox‐Neutral Approach." Advanced Science, July 2, 2025. https://doi.org/10.1002/advs.202509922.

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AbstractOrganophosphinic acids, R2P(O)(OH), and their derivatives are versatile compounds with applications in catalysis, material chemistry, biomolecular bridging, metal extraction, and flame retardancy. Current synthetic methods primarily rely on white phosphorus (P4) as a precursor, which is converted into nucleophilic or electrophilic P‐synthons through acid‐/base‐induced disproportionation (e.g., PH3, [H2PO2]–) or chlorination (PCl3). However, P4 poses significant drawbacks due to its highly pyrophoric nature, environmental hazards, and the energy‐intensive production process from phospha

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Prasetyanto, Eko Adi, Youssef Atoini, Loic Donato, Chien-Wei Hsu, and Luisa De Cola. "The Role of a Confined Space on the Reactivity and Emission Properties of Copper(I) Clusters." Frontiers in Chemistry 10 (May 5, 2022). http://dx.doi.org/10.3389/fchem.2022.829538.

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Metal clusters have gained a lot of interest for their remarkable photoluminescence and catalytic properties. However, a major drawback of such materials is their poor stability in air and humidity conditions. Herein we describe a versatile method to synthesize luminescent Cu(I) clusters inside the pores of zeolites, using a sublimation technique with the help of high vacuum and high temperature. The porous materials play an essential role as a protecting media against the undesirable and easy oxidation of Cu(I). The obtained clusters show fascinating luminescence properties, and their reactiv

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