Academic literature on the topic 'Phospholipase C'

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Journal articles on the topic "Phospholipase C"

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Bollag, Wendy B. "Role of phospholipases in adrenal steroidogenesis." Journal of Endocrinology 229, no. 1 (2016): R29—R41. http://dx.doi.org/10.1530/joe-16-0007.

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Phospholipases are lipid-metabolizing enzymes that hydrolyze phospholipids. In some cases, their activity results in remodeling of lipids and/or allows the synthesis of other lipids. In other cases, however, and of interest to the topic of adrenal steroidogenesis, phospholipases produce second messengers that modify the function of a cell. In this review, the enzymatic reactions, products, and effectors of three phospholipases, phospholipase C, phospholipase D, and phospholipase A2, are discussed. Although much data have been obtained concerning the role of phospholipases C and D in regulating
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Hawrylak, K., and R. A. Stinson. "Phospholipase C and phosphatidylinositol phospholipase C." Clinical Chemistry 33, no. 2 (1987): 337. http://dx.doi.org/10.1093/clinchem/33.2.337.

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Dhand, Rajiv, Jared Young, Andelle Teng, Subbiah Krishnasamy, and Nicholas J. Gross. "Is dipalmitoylphosphatidylcholine a substrate for convertase?" American Journal of Physiology-Lung Cellular and Molecular Physiology 278, no. 1 (2000): L19—L24. http://dx.doi.org/10.1152/ajplung.2000.278.1.l19.

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Convertase has homology with carboxylesterases, but its substrate(s) is not known. Accordingly, we determined whether dipalmitoylphosphatidylcholine (DPPC), the major phospholipid in surfactant, was a substrate for convertase. We measured [3H]choline release during cycling of the heavy subtype containing [3H]choline-labeled DPPC with convertase, phospholipases A2, B, C, and D, liver esterase, and elastase. Cycling with liver esterase or peanut or cabbage phospholipase D produced the characteristic profile of heavy and light peaks observed on cycling with convertase. In contrast, phospholipases
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Karasawa, Tadahiro, Xingmin Wang, Tsuneo Maegawa, et al. "Clostridium sordellii Phospholipase C: Gene Cloning and Comparison of Enzymatic and Biological Activities with Those of Clostridium perfringens and Clostridium bifermentans Phospholipase C." Infection and Immunity 71, no. 2 (2003): 641–46. http://dx.doi.org/10.1128/iai.71.2.641-646.2003.

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ABSTRACT The gene encoding Clostridium sordellii phospholipase C (Csp) was cloned and expressed as a histidine-tagged (His-tag) protein, and the protein was purified to compare its enzymatic and biological activities with those of Clostridium perfringens phospholipase C (Cpa) and Clostridium bifermentans phospholipase C (Cbp). Csp was found to consist of 371 amino acid residues in the mature form and to be more homologous to Cbp than to Cpa. The egg yolk phospholipid hydrolysis activity of the His-tag Csp was about one-third of that of His-tag Cpa, but the hemolytic activity was less than 1% o
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Teitelbaum, I. "Hormone signaling systems in inner medullary collecting ducts." American Journal of Physiology-Renal Physiology 263, no. 6 (1992): F985—F990. http://dx.doi.org/10.1152/ajprenal.1992.263.6.f985.

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The inner medullary collecting duct is a complex tissue that exhibits a variety of hormone signaling systems. These include the following: adenylyl cyclase activity stimulated by vasopressin (AVP), beta-adrenergic agonists, or prostanoids and inhibited by alpha 2-adrenergic agents or adenosine; guanylate cyclase activity in response to atrial natriuretic peptide (ANP); phospholipase C activity stimulated by ANP, AVP, bradykinin, endothelin, epidermal growth factor (EGF), and muscarinic cholinergic agents; and phospholipase A2 activity stimulated by AVP, bradykinin, EGF, and endothelin. The sig
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Ghannoum, Mahmoud A. "Potential Role of Phospholipases in Virulence and Fungal Pathogenesis." Clinical Microbiology Reviews 13, no. 1 (2000): 122–43. http://dx.doi.org/10.1128/cmr.13.1.122.

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SUMMARY Microbial pathogens use a number of genetic strategies to invade the host and cause infection. These common themes are found throughout microbial systems. Secretion of enzymes, such as phospholipase, has been proposed as one of these themes that are used by bacteria, parasites, and pathogenic fungi. The role of extracellular phospholipase as a potential virulence factor in pathogenic fungi, including Candida albicans, Cryptococcus neoformans, and Aspergillus, has gained credence recently. In this review, data implicating phospholipase as a virulence factor in C. albicans, Candida glabr
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LITTLE, CLIVE. "Phospholipase C." Biochemical Society Transactions 17, no. 2 (1989): 271–73. http://dx.doi.org/10.1042/bst0170271.

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Heo, Yunseok, Inhwan Lee, Sunjin Moon, et al. "Crystal Structures of the Plant Phospholipase A1 Proteins Reveal a Unique Dimerization Domain." Molecules 27, no. 7 (2022): 2317. http://dx.doi.org/10.3390/molecules27072317.

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Phospholipase is an enzyme that hydrolyzes various phospholipid substrates at specific ester bonds and plays important roles such as membrane remodeling, as digestive enzymes, and the regulation of cellular mechanism. Phospholipase proteins are divided into following the four major groups according to the ester bonds they cleave off: phospholipase A1 (PLA1), phospholipase A2 (PLA2), phospholipase C (PLC), and phospholipase D (PLD). Among the four phospholipase groups, PLA1 has been less studied than the other phospholipases. Here, we report the first molecular structures of plant PLA1s: AtDSEL
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Tanabe, Kumiko, Osamu Kozawa, Hiroyuki Matsuno, Masayuki Niwa, Shuji Dohi, and Toshihiko Uematsu. "Effect of Propofol on Arachidonate Cascade by Vasopressin in Aortic Smooth Muscle Cells." Anesthesiology 90, no. 1 (1999): 215–24. http://dx.doi.org/10.1097/00000542-199901000-00028.

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Background The mechanisms underlying the vascular effects of propofol are not fully understood. Vasopressin, a potent vasoactive peptide, stimulates the arachidonate cascade and the synthesis of prostacyclin (PGI2; the main metabolite of the cascade in vascular smooth muscle cells). Arachidonic acid (AA) release by phospholipases is the rate-limiting step in the cascade. We investigated the mechanisms underlying vasopressin-induced AA release and the effect of propofol on PGI2 synthesis in a rat aortic smooth muscle cell line: A10 cells. Methods In cultured A10 cells pretreated with propofol,
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Inamori, K., N. Sagawa, M. Hasegawa, H. Itoh, J. Yano, and T. Mori. "Activation of phospholipase D in cultured human amnion cells." Reproduction, Fertility and Development 7, no. 6 (1995): 1591. http://dx.doi.org/10.1071/rd9951591.

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The regulation of phospholipase D (PLD) activity in the human amniotic membrane was examined using primary cultures of amnion cells. Cultured amnion cells were labelled with [3H]oleic acid, and PLD activity was determined as the amount of [3H]phosphatidylethanol (PEt) produced during incubation in the presence of 0.1% ethanol. PLD activity in cultured amnion cells was activated by addition of arginine vasopressin and oxytocin. PLD activity was also stimulated by treatment was arachidonic acid, the product of phospholipase A2 (PLA2), and phospholipase C (PLC). These results indicate that PLD in
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Dissertations / Theses on the topic "Phospholipase C"

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Zhou, Yixing Harden T. Kendall. "Cloning and characterization of a novel phospholipase C enzyme, human phospholipase C eta2." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2007. http://dc.lib.unc.edu/u?/etd,1271.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2007.<br>Title from electronic title page (viewed Mar. 26, 2008). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Pharmacology." Discipline: Pharmacology; Department/School: Medicine.
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Lin, Gialih Hoffmann. "Stereochemistry and mechanism of phospholipase A2 and phosphatidylinositide-specific phospholipase C /." The Ohio State University, 1989. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487672245900381.

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Tong, Yun. "Phosphoinositide-phospholipase C in diabetic cardiomyopathy." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0001/MQ32268.pdf.

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Zhao, Li. "Mechanistic studies on phosphatidylinositol-specific phospholipase C." Connect to this title online, 2003. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1047485476.

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Thesis (Ph. D.)--Ohio State University, 2003.<br>Title from first page of PDF file. Document formatted into pages; contains xix, 135 p.; also includes graphics (some col.) Includes bibliographical references (p. 128-135). Available online via OhioLINK's ETD Center
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Donahue, Vicki S. "Phospholipase c activity in retinal pigment epithelium." Virtual Press, 1997. http://liblink.bsu.edu/uhtbin/catkey/1041916.

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The role of the retinal pigment epithelial cells on the viability and renewal of photoreceptors has been well demonstrated in the Royal College of Surgeons (RCS) strain of rat. These rats are characterized by an inherited time-dependent degeneration of their photoreceptors. This degeneration is apparently due to the inability of the retinal pigment epithelial cells to adequately ingest fragments of photoreceptor membrane that are shed during the course of photoreceptor membrane renewal. The buildup of photoreceptor material in the interphotoreceptor space ultimately leads to the degeneration o
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Clark, Graeme Christopher. "Characterisation and exploitation of clostridial phospholipase C." Thesis, Birkbeck (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406120.

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Blank, Jonathan Louis. "The phospholipase C specific for the phosphoinositides." Thesis, University of Nottingham, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.252943.

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Meldrum, Eric. "Isolation and characterization of mammalian phospholipase C." Thesis, Open University, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.258438.

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Chrétien, Louise. "Régulation de l'activité de la phospholipase C par les récepteurs AT [indice] 1 de l'angiotensine II et B [indice] 2 de la bradykinine." Sherbrooke : Université de Sherbrooke, 1998.

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Nazih, Hassan. "Hdl3, plaquettes et seconds messagers : caracterisation et regulation du systeme de transduction." Lille 2, 1993. http://www.theses.fr/1993LIL2P261.

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Books on the topic "Phospholipase C"

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Tobin, A. B. The Phospholipase C pathway: Its regulation and desenisitization. R.G. Landes, 1996.

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Seib, Christine. Isolierung und Charakterisierung von Phospholipase C aus Schweinehirn. [s.n.], 1991.

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Brazil, Derek P. Regulation of phospholipase C-[beta]2 by G protein [beta] [gamma] subunits. University College Dublin, 1996.

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Pfaffmann, Helmut. Nachweis, Isolierung und Kompartimentierung einer Phosphatidylinositol-spezifischen Phospholipase C in Pflanzen. [s.n.], 1988.

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Perera, Nevin Martin. Phospholipase C activation is implicated in the responses of yeast to several stresses. University of Birmingham, 2002.

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Brind, Robert Ian. The characterisation of Plc1: A phospholipase C enzyme identified in the fission yeast Schizosaccharomyces pombe. typescript, 2000.

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Idestrup, Chris. P2Y-and P2U-purinoceptor activation cause intracellualr CA2+ release in dorsal spinal astrocytes via the phospholipase C[BETA]/IP3 pathway. National Library of Canada, 1996.

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Slaaby, Rita. Cloning and characterisation of a phosphoinositide-specific phospholipase C in Schizosaccharomyces pombe and isolation and characterisation of pheromone induced cell cycle arrest mutants in Schizosaccharomyces pombe. University of Birmingham, 1996.

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N, Fain John, ed. Lipid metabolism in signaling systems. Academic Press, 1993.

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N, Fain John, ed. Lipid metabolism in signalling systems. Academic Press, Inc., 1993.

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Book chapters on the topic "Phospholipase C"

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Lackner, K. J., and D. Peetz. "Phospholipase C." In Lexikon der Medizinischen Laboratoriumsdiagnostik. Springer Berlin Heidelberg, 2018. http://dx.doi.org/10.1007/978-3-662-49054-9_2425-1.

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Lackner, K. J., and D. Peetz. "Phospholipase C." In Springer Reference Medizin. Springer Berlin Heidelberg, 2019. http://dx.doi.org/10.1007/978-3-662-48986-4_2425.

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Vines, Charlotte M. "Phospholipase C." In Advances in Experimental Medicine and Biology. Springer Netherlands, 2012. http://dx.doi.org/10.1007/978-94-007-2888-2_10.

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Schomburg, Dietmar, and Margit Salzmann. "Phospholipase C." In Enzyme Handbook 3. Springer Berlin Heidelberg, 1991. http://dx.doi.org/10.1007/978-3-642-76463-9_115.

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Bill, Colin A., and Charlotte M. Vines. "Phospholipase C." In Advances in Experimental Medicine and Biology. Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-12457-1_9.

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Cuatrecasas, Pedro. "Some Novel Phospholipase C Activities." In Cellular and Molecular Aspects of Inflammation. Springer US, 1988. http://dx.doi.org/10.1007/978-1-4684-5487-1_20.

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Rhee, Sue Goo, and Yun Soo Bae. "Regulation of Phospholipase C isozymes." In Interacting Protein Domains. Springer Berlin Heidelberg, 1997. http://dx.doi.org/10.1007/978-3-642-60848-3_14.

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Schomburg, Dietmar, and Dörte Stephan. "Variant-surface-glycoprotein phospholipase C." In Enzyme Handbook 15. Springer Berlin Heidelberg, 1998. http://dx.doi.org/10.1007/978-3-642-58948-5_39.

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Pejchar, Přemysl, Günther F. E. Scherer, and Jan Martinec. "Assaying Nonspecific Phospholipase C Activity." In Methods in Molecular Biology. Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-401-2_18.

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Schinner, Franz, Richard Öhlinger, and Ellen Kandeler. "Bestimmung der Phospholipase C-Aktivität." In Bodenbiologische Arbeitsmethoden. Springer Berlin Heidelberg, 1991. http://dx.doi.org/10.1007/978-3-642-97284-3_39.

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Conference papers on the topic "Phospholipase C"

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Deykin, D., and R. M. Karmer. "DIRECT STIMULATIONOF CA2+-ACTIVATED HUMAN PLATELET PHOSPHOLIPASE A2 BY DIACYLGLYCEROL." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644673.

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These studies examined the effect of diacylglycerol on Ca2+-dependent phospholipase A2 from human platelets. Phospholipase A2 was solubilized and partially purified to a stable form in the presence of octylglucoside and its enzymatic activity determined using sonicated arachidonoyl phosphatidylcholine (PC) as substrate. (Kramer RM, et al: BBA 878:394, 1986) Phospholipase A2 activity was increased when dioleoylglycerc_ was incorporated into the substrate arachidonoyl-PC. In the presence of 1 uM (29 mol %) sn-1,2-dioleoylglycerol the enzymatic activity was stimulated 4.1-fold. Exogenously added
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Lapetina, Eduardo G. "THE ROLE OF INOSITIDES, PHOSPHOLIPASE C AND G-PROTEINS IN RECEPTOR TRANSDUCTION." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644775.

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It is now widely recognized that the activation of phospholipase C by specific agonists leads to the formation of two second messengers: (1) inositol trisphosphate, which releases Ca2+ from the endoplasmic reticulum to the cytosol and (2) 1,2- diacylglycerol, which stimulates protein kinase C. In the past few years, GTP-binding proteins have been associated with the regulation of phospholipase C. However, the identity of the GTP-binding protein involved and the type of association with phospholipase C is not yet known. It is now recognized that there are two types of phospholipase C enzymes: (
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Outlaw, Kennedy, Isaac J. Fisher, Kaushik Muralidharan та Angeline Lyon. "Structural and Functional Characterization of Phospholipase C β3". У ASPET 2023 Annual Meeting Abstracts. American Society for Pharmacology and Experimental Therapeutics, 2023. http://dx.doi.org/10.1124/jpet.122.249970.

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Nakashima, S., T. Tohmatsu, H. Hattori, A. Suganuma, and Y. Nozawa. "EVIDENCE FOR INVOLVEMENT OF GTP-BINDING PROTEIN IN ARACKIDONIC ACID RELEASE BY PHOSPHOLIPASE A2 IN PERMEABILIZED HUMAN PLATELETS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644631.

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Platelet activation is accompanied by the active metabolism of membrane phospholipids. Phosphoinositide breakdown by phospholipase C generates second messengers; inositol trisphosphate and diacylglycerol. Recently, it is suggested that GTP-binding protein is linked to the activation of phospholipase C as is true for adenylate cyclase. Although it is known that the receptor stimulation by agonists leads to generation of arachidonic acid, its molecular mechanism has not yet been clear. However, several studies in neutrophils and mast cells using pertussis toxin, have shown the possibility that a
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Crouch, Michael F., and Eduardo G. Lapetina. "PHOSPHOLIPASE A2 ACTIVATION BY A MECHANISM SEPARATE TO THAT RESPONSIBLE FOR PHOSPHOLIPASE C STIMULATION IN ALPHA-THROMBIN-STIMULATED HUMAN PLATELETS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644470.

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The ability of cell surface receptor occupation to increase the activity of phospholipase A2 has been thought to be due to the prior activation of phospholipase C and an increase in the intracellular Ca2+ concentration. However, recent evidence from our and other laboratories has suggested that this may not be the case, but rather stimulation of phospholipase A2 may be under the control of separate receptor-activated events. We have investigated this further by comparing the ability of prostacyclin (PGI2) and epinephrine to alter platelet responses to thrombin and examining the resulting phosp
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Merkuleva, Iu A., D. N. Shcherbakov, and A. A. Bondar. "Development of recombinant phosphatidylcholine-specific phospholipase C from Bacillus thuringiensis." In ACTUAL PROBLEMS OF ORGANIC CHEMISTRY AND BIOTECHNOLOGY (OCBT2020): Proceedings of the International Scientific Conference. AIP Publishing, 2022. http://dx.doi.org/10.1063/5.0069626.

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Zhou, Mingjie, Cailan Zhang, and Richard P. Haugland. "Choline oxidase: a useful tool for high-throughput assays of acetylcholinesterase, phospholipase D, phosphatidylcholine-specific phospholipase C, and sphingomyelinase." In BiOS 2000 The International Symposium on Biomedical Optics, edited by Patrick A. Limbach, John C. Owicki, Ramesh Raghavachari, and Weihong Tan. SPIE, 2000. http://dx.doi.org/10.1117/12.380507.

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Chirkova, V. Yu, D. N. Shcherbakov, and I. Yu Evdokimov. "DAILY DYNAMICS OF THE ACTIVITY OF RECOMBINANT PHOSPHOLIPASE C OBTAINED IN THE BACILLUS MOJAVENSIS SYSTEM DURING SUBMERGED CULTIVATION IN A SEMI-INDUSTRIAL FERMENTER." In X Международная конференция молодых ученых: биоинформатиков, биотехнологов, биофизиков, вирусологов и молекулярных биологов — 2023. Novosibirsk State University, 2023. http://dx.doi.org/10.25205/978-5-4437-1526-1-146.

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As a result of experimental deep cultivation of a new strain-producer of recombinant phospholipase C in the Bacillus mojavensis system in a semi-industrial 250-liter bioreactor, an enzyme preparation was obtained with a maximum phospholipase activity of 307.35 units/ml after 8 h of operation at 37 ºС.
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Scarlata, Suzanne, Loren Runnels та Mario Rebecchi. "Detection of phospholipase C-β 2 activation by G-protein subunits". У BiOS '98 International Biomedical Optics Symposium, редактори Joseph R. Lakowicz та J. B. Alexander Ross. SPIE, 1998. http://dx.doi.org/10.1117/12.307051.

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Bijli, Kaiser M., Fabeha Fazal, Alan Smrcka, and Arshad Rahman. "Critical Role Of Phospholipase C Epsilon In Lipopolysaccharide-Induced Lung Inflammation." In American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado. American Thoracic Society, 2011. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a4189.

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Reports on the topic "Phospholipase C"

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Luberto, Chiara. Identification of the Elusive Mammalian Enzyme Phosphatidylcholine-Specific Phospholipase C. Defense Technical Information Center, 2014. http://dx.doi.org/10.21236/ada611640.

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