Relevant bibliographies by topics / PHOSPHOLIPASES A/analysis

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'PHOSPHOLIPASES A/analysis'

Author: Grafiati
Published: 4 June 2021
Last updated: 11 February 2022

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Journal articles on the topic "PHOSPHOLIPASES A/analysis"

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Emiliani, Yuliana, Andrés Sánchez, Marlon Munera, Jorge Sánchez, and Dilia Aparicio. "In silico analysis of cross reactivity among phospholipases from Hymenoptera species." F1000Research 10 (January 5, 2021): 2. http://dx.doi.org/10.12688/f1000research.27089.1.

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Background: Phospholipases are enzymes with the capacity to hydrolyze membrane lipids and have been characterized in several allergenic sources, such as hymenoptera species. However, cross-reactivity among phospholipases allergens are little understood. The objective of this study was to determine potential antigenic regions involved in cross-reactivity among allergens of phospholipases using an in silico approach. Methods: In total, 18 amino acids sequences belonging to phospholipase family derived from species of the order hymenoptera were retrieved from the UniProt database to perform phylo
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Emiliani, Yuliana, Andrés Sánchez, Marlon Munera, Jorge Sánchez, and Dilia Aparicio. "In silico analysis of cross reactivity among phospholipases from Hymenoptera species." F1000Research 10 (March 29, 2021): 2. http://dx.doi.org/10.12688/f1000research.27089.2.

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Background: Phospholipases are enzymes with the capacity to hydrolyze membrane lipids and have been characterized in several allergenic sources, such as hymenoptera species. However, cross-reactivity among phospholipases allergens are little understood. The objective of this study was to determine potential antigenic regions involved in cross-reactivity among allergens of phospholipases using an in silico approach. Methods: In total, 18 amino acids sequences belonging to phospholipase family derived from species of the order hymenoptera were retrieved from the UniProt database to perform phylo
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Kunze, Donika, Inga Melzer, Désirée Bennett, et al. "Functional analysis of the phospholipase C gene CaPLC1 and two unusual phospholipase C genes, CaPLC2 and CaPLC3, of Candida albicans." Microbiology 151, no. 10 (2005): 3381–94. http://dx.doi.org/10.1099/mic.0.28353-0.

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Phospholipases C are known to be important regulators of cellular processes but may also act as virulence factors of pathogenic microbes. At least three genes in the genome of the human-pathogenic fungus Candida albicans encode phospholipases with conserved phospholipase C (Plc) motifs. None of the deduced protein sequences contain N-terminal signal peptides, suggesting that these phospholipases are not secreted. In contrast to its orthologue in Sacharomyces cerevisiae, CaPLC1 seems to be an essential gene. However, a conditional mutant with reduced transcript levels of CaPLC1 had phenotypes s
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Rice, K. L., P. G. Duane, G. Mielke, A. A. Sinha, and D. E. Niewoehner. "Calcium ionophores injure alveolar epithelial cells: relation to phospholipase activity." American Journal of Physiology-Lung Cellular and Molecular Physiology 259, no. 6 (1990): L439—L450. http://dx.doi.org/10.1152/ajplung.1990.259.6.l439.

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Phospholipases and certain of their hydrolytic products are toxic to alveolar epithelial cells. Since many intracellular phospholipases are Ca2+ dependent, we postulated that elevating cytosolic Ca2+ with ionophores might cause epithelial injury via phospholipase activation. Isolated perfused hamster lungs exposed to an Ca2+ ionophore A23187 develop functional evidence of severe epithelial injury. Ultrastructural studies show widespread lysis of type I epithelial cells, with only minimal abnormalities in other lung cells, including the microvascular endothelium. Analysis of whole lung lipid ex
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Navas, Laura Emilce, Mónica Florin-Christensen, Graciela Beatriz Benintende, Rubén Oreste Zandomeni, and Marcelo Facundo Berretta. "Characterization of a Novel Thermostable Enzyme from Thermus sp. 2.9 with Phospholipase and Acyltransferase Activities." Journal of Molecular Microbiology and Biotechnology 28, no. 3 (2018): 99–106. http://dx.doi.org/10.1159/000491698.

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Phospholipases are classified in different enzyme families according to the ester bond they cleave within phospholipids. The use of phospholipases in industrial processes has prompted the search for new enzymes with differential properties. A gene encoding a novel phospholipase (PLP_2.9) was identified in the genome of the thermophilic strain <i>Thermus</i> sp. 2.9. The analysis of the primary sequence unveiled a patatin-like domain. The alignment of the amino acid sequence of PLP_2.9 to other bacterial patatin-related proteins showed that the four blocks characteristic of this typ
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Karasawa, Tadahiro, Xingmin Wang, Tsuneo Maegawa, et al. "Clostridium sordellii Phospholipase C: Gene Cloning and Comparison of Enzymatic and Biological Activities with Those of Clostridium perfringens and Clostridium bifermentans Phospholipase C." Infection and Immunity 71, no. 2 (2003): 641–46. http://dx.doi.org/10.1128/iai.71.2.641-646.2003.

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ABSTRACT The gene encoding Clostridium sordellii phospholipase C (Csp) was cloned and expressed as a histidine-tagged (His-tag) protein, and the protein was purified to compare its enzymatic and biological activities with those of Clostridium perfringens phospholipase C (Cpa) and Clostridium bifermentans phospholipase C (Cbp). Csp was found to consist of 371 amino acid residues in the mature form and to be more homologous to Cbp than to Cpa. The egg yolk phospholipid hydrolysis activity of the His-tag Csp was about one-third of that of His-tag Cpa, but the hemolytic activity was less than 1% o
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Anderson, David M., Hiromi Sato, Aaron T. Dirck, Jimmy B. Feix, and Dara W. Frank. "Ubiquitin Activates Patatin-Like Phospholipases from Multiple Bacterial Species." Journal of Bacteriology 197, no. 3 (2014): 529–41. http://dx.doi.org/10.1128/jb.02402-14.

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Phospholipase A2enzymes are ubiquitously distributed throughout the prokaryotic and eukaryotic kingdoms and are utilized in a wide array of cellular processes and physiological and immunological responses. Several patatin-like phospholipase homologs of ExoU fromPseudomonas aeruginosawere selected on the premise that ubiquitin activation of this class of bacterial enzymes was a conserved process. We found that ubiquitin activated all phospholipases tested in bothin vitroandin vivoassays via a conserved serine-aspartate catalytic dyad. Ubiquitin chains versus monomeric ubiquitin were superior in
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Chandra, Vikas, Akanksha Nagpal, A. Srinivasan, and T. P. Singh. "Purification, crystallization and preliminary X-ray crystallographic analysis of a phospholipase A2 from Daboia russelli pulchella." Acta Crystallographica Section D Biological Crystallography 55, no. 4 (1999): 925–26. http://dx.doi.org/10.1107/s090744499900058x.

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Phospholipases are esterolytic enzymes which hydrolyze glycerophospholipids. The pharmacological efficiency of phospholipase A2 (PLA2) enzymes is reflected by their specificity towards a tissue or organ. The Russell's viper has been classified into two classes. Class 1 contains Viper russelli russelli, Viper russelli siamensis and Viper russelli formosensis, whereas class 2 contains Daboia russelli pulchella. The sequence identity between the PLA2s from these two classes is 47%. The novel PLA2 from Daboia russelli pulchella has been crystallized using the hanging-drop vapour-diffusion method w
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STANTON, Julie D., Mohammad B. RASHID, and Kojo MENSA-WILMOT. "Cysteine-less glycosylphosphatidylinositol-specific phospholipase C is inhibited competitively by a thiol reagent: evidence for glyco-mimicry by p-chloromercuriphenylsulphonate." Biochemical Journal 366, no. 1 (2002): 281–88. http://dx.doi.org/10.1042/bj20020367.

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Glycosylphosphatidylinositol (GPI)-specific phospholipases are highly valuable for studying the structure and function of GPIs. GPI-specific phospholipase C (GPI-PLC) from Trypanosoma brucei and phosphatidylinositol-specific phospholipase C (PI-PLC) from Bacillus cereus are the most widely studied of this class of phospholipases C. Inhibition of protein activity by thiol reagents is indicative of the participation of cysteine residues in biochemical events. The thiol reagent p-chloromercuriphenylsulphonate (pCMPS) inhibits T. brucei GPI-PLC, which has eight cysteine residues. Surprisingly, we
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Lee, Mi-Hwa, Ki-Hoon Oh, Chul-Hyung Kang, et al. "Novel Metagenome-Derived, Cold-Adapted Alkaline Phospholipase with Superior Lipase Activity as an Intermediate between Phospholipase and Lipase." Applied and Environmental Microbiology 78, no. 14 (2012): 4959–66. http://dx.doi.org/10.1128/aem.00260-12.

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ABSTRACTA novel lipolytic enzyme was isolated from a metagenomic library obtained from tidal flat sediments on the Korean west coast. Its putative functional domain, designated MPlaG, showed the highest similarity to phospholipase A fromGrimontia hollisaeCIP 101886, though it was screened from an emulsified tricaprylin plate. Phylogenetic analysis showed that MPlaG is far from family I.6 lipases, includingStaphylococcus hyicuslipase, a unique lipase which can hydrolyze phospholipids, and is more evolutionarily related to the bacterial phospholipase A1family. The specific activities of MPlaG ag
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Dissertations / Theses on the topic "PHOSPHOLIPASES A/analysis"

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Bayburt, Timothy. "Kinetic analysis of the 85 kDa cytosolic phospholipase A2 on anionic phospholipid vesicles /." Thesis, Connect to this title online; UW restricted, 1996. http://hdl.handle.net/1773/9220.

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Jardim, Luciana Souza Alcântara. ""Efeitos da atividade da fosfolipase A2 nos receptores dopaminérgicos: implicações para a esquizofrenia"." Universidade de São Paulo, 2005. http://www.teses.usp.br/teses/disponiveis/5/5160/tde-03012006-093632/.

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Um aumento da atividade da PLA2 e alterações do sistema dopaminérgico tem sido descrito em esquizofrenia. No presente estudo, foram investigados os efeitos da atividade da PLA2 sobre os receptores D1 e D2 em cérebro post mortem de 10 sujeitos. Foi encontrado que a PLA2GVI é responsável por 85% do total de atividade da PLA2 no cérebro. A estimulação da PLA2GVI (por EDTA) aumentou a afinidade de D1 em estriado e em CPF e diminuiu a afinidade de D2 em estriado. A inibição da PLA2GVI (por BEL) diminuiu a afinidade de D1 em estriado, e em CPF e CT. A estimulação da PLA2GVI resultou em aumento na de
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Leslie, Dario Lyall. "Genetic analysis of alpha toxin (phospholipase C) from Clostridium perfringens." Thesis, University of Newcastle Upon Tyne, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.346420.

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Boukli-Hacène, Latifa. "Inhibiteurs de la phospholipase A2 recombinante humaine : synthèse, analyses spectroscopiques : relations structure-activité." Paris 7, 2001. http://www.theses.fr/2001PA077266.

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Suite à une lésion, l'organisme s'adapte puis se défend, il s'agit de la réaction inflammatoire. Ce processus est donc bénéfique mais peut générer des complications sévères et incontrôlables; c'est le cas des pathologies inflammatoires. Nous citerons l'asthme, l'allergie et le choc septique. Bien que l'on ne connaisse pas entièrement son rôle dans le processus inflammatoire, la snpPLA₂ apparaît comme une cible certaine puisqu'elle est présente à des taux très élevés dans les liquides biologiques issus de foyers inflammatoires. De ce fait son inhibition représente une alternative thérapeutique
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Olson, Erin Dalene. "A comparative analysis of hydrolysis kinetics by sPLA₂ isoforms during adoptosis in S49 cells /." Diss., CLICK HERE for online access, 2008. http://contentdm.lib.byu.edu/ETD/image/etd2539.pdf.

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Gonzalez, Adriana [Verfasser]. "Biochemical characterization and functional analysis of phospholipase D3 (PLD3) / Adriana Gonzalez." Kiel : Universitätsbibliothek Kiel, 2019. http://d-nb.info/1184274894/34.

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Valentin, Emmanuel. "Diversité structurale des phospholipases A2 sécrétées : clonage et étude fonctionnelle de nouvelles enzymes." Nice, 2000. http://www.theses.fr/2000NICE5473.

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Les phospholipases A2 hydrolysent la liaison ester en position 2 des phospholipides, libérant un acide gras et un lysophospholipide. Ces enzymes jouent un rôle dans la libération d'acide arachidonique et de ses métabolites. Elles interviennent dans des fonctions telles que la digestion, l'inflammation, la défense antibactérienne, le cancer ou l'athérosclérose. Au moins quinze gènes de phospholipases A2 intracellulaires et sécrétées (sPLA2) sont connus. Trois nouvelles sPLA2 de groupe II ont été clonées au cours de cette thèse. Une sPLA2 humaine de groupe III a aussi été clonée. Une sPLA2 de gr
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Hyvönen, M. (Marja). "Molecular dynamics simulations on phospholipid membranes." Doctoral thesis, University of Oulu, 2001. http://urn.fi/urn:isbn:9514259432.

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Abstract Phospholipids are the main components of cell membranes, lipoproteins and other membrane structures in living organisms. Properties of lipid molecules are important to the overall behaviour and interactions of membranes. Furthermore, characteristics of the biological membranes act as important regulators of membrane functions. Molecular dynamics (MD) simulations were applied in this thesis to study properties of biological membranes. A certain degree of acyl chain polyunsaturation is essential for the proper functioning of membranes, but earlier MD simulations had not addressed
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Millard, Alexander. "Analysis of PI-PLC Binding to PC and PMe Vesicle Surfaces Using EPR and NMR." Thesis, Boston College, 2005. http://hdl.handle.net/2345/361.

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Thesis advisor: Mary F. Roberts<br>Phosphatidylinositol-specific phospholipase C (PI-PLC) is an enzyme important in membrane-associated signal transduction in eukaryotes, and pathogenic factors in bacteria. It catalyzes the conversion of PI to DAG and cIP, which is further converted to I-1-P. The phospholipid PC has been shown to activate cIP hydrolysis. EPR and NMR were used to examine PI-PLC binding to PC and PMe vesicles through the use of spin labels attached to cysteine mutants. It was concluded that the spin label interacted more significantly with the phosphorus of PC than that of PMe.
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Touaibia, Mohamed. "Inhibiteurs de la phospholipase A2 de groupe II : synthèse, analyses spectroscopiques : relations structure-activité." Paris 7, 2002. http://www.theses.fr/2002PA077247.

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Books on the topic "PHOSPHOLIPASES A/analysis"

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N, Fain John, ed. Lipid metabolism in signalling systems. Academic Press, Inc., 1993.

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Methods in Neurosciences: Lipid Metabolism in Signaling Systems (Methods in Neurosciences). Academic Press, 1993.

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N, Fain John, ed. Lipid metabolism in signaling systems. Academic Press, 1993.

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Book chapters on the topic "PHOSPHOLIPASES A/analysis"

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Grossman, Shlomo, Guillermo Oestreicher, and Thomas P. Singer. "Determination of the Activity of Phospholipases A, C, and D." In Methods of Biochemical Analysis. John Wiley & Sons, Inc., 2006. http://dx.doi.org/10.1002/9780470110423.ch4.

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Pazzini, Fabiano, Fernanda Oliveira, Jorge A. Guimarães, and Hermes Luís Neubauer de Amorim. "Prediction of Myotoxic and Neurotoxic Activities in Phospholipases A2 from Primary Sequence Analysis." In Advances in Bioinformatics and Computational Biology. Springer Berlin Heidelberg, 2005. http://dx.doi.org/10.1007/11532323_21.

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Carlier, M. B., R. Brasseur, J. M. Ruysschaert, and P. M. Tulkens. "In Vitro Study and Conformational Analysis of 1-N-Aminohydroxybutyryl Derivatives of Aminoglycosides in Correlation with Their Inhibitory Potency Towards Lysosomal Phospholipases." In Archives of Toxicology. Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-73113-6_30.

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Novotná, Z., O. Valentová, J. Daussant, and J. Káš. "Purification and Immunological Analysis of Phospholipase D from Brassica Napus (Rape Seed)." In Physiology, Biochemistry and Molecular Biology of Plant Lipids. Springer Netherlands, 1997. http://dx.doi.org/10.1007/978-94-017-2662-7_128.

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Zhao, Jian, and Xuemin Wang. "Biochemical Analysis of the Interaction Between Phospholipase Dα1 and GTP-Binding Protein α-Subunit from Arabidopsis thaliana." In Methods in Molecular Biology. Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-532-3_3.

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Collins, A. Bernard, and R. Neal Smith. "Western Blot Analysis for the Detection of Anti-Glomerular Basement Membrane Antibodies and Anti-Phospholipase A2 Receptor Antibodies." In Manual of Molecular and Clinical Laboratory Immunology. ASM Press, 2016. http://dx.doi.org/10.1128/9781555818722.ch42.

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Heinrikson, Robert L. "[18] Dissection and sequence analysis of phospholipases A2." In Methods in Enzymology. Elsevier, 1991. http://dx.doi.org/10.1016/0076-6879(91)97146-p.

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G., Rodrigo, Rodrigo Simoes-Silva, Anderson M., et al. "Purification of Phospholipases A2 from American Snake Venoms." In Chromatography - The Most Versatile Method of Chemical Analysis. InTech, 2012. http://dx.doi.org/10.5772/53052.

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Brown, H. Alex, Lee G. Henage, Anita M. Preininger, Yun Xiang, and John H. Exton. "Biochemical Analysis of Phospholipase D." In Methods in Enzymology. Elsevier, 2007. http://dx.doi.org/10.1016/s0076-6879(07)34004-4.

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Blank, Merle L., and Fred Snyder. "[14] Chromatographic analysis of phospholipase reaction products." In Methods in Enzymology. Elsevier, 1991. http://dx.doi.org/10.1016/0076-6879(91)97142-l.

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Conference papers on the topic "PHOSPHOLIPASES A/analysis"

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Tonello, Fiorella, and Caterina Peggion. "<em>In silico</em> analysis of short linear motifs present in snake venom phospholipases A2." In 1st International Electronic Conference on Toxins. MDPI, 2021. http://dx.doi.org/10.3390/iect2021-09137.

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Hattori, A., R. Nagayama, I. Fuse, T. Takeshige, S. Takizawa, and A. Shibata. "FURTHER CHARACTERIZATION OF PLATELET RELEASE MECHANISM DEFECT WITH DEFECTIVE A23187 AGGREGATION." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644878.

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In order to clarify the basic abnormality of patients with release mechanism abnormality with defective response to A23187 (A23) (Hattori et al. Acta Haematol. Jap. 44:969, 1981), the proband (female) showing a life long mild hemorrhagic tendency was further examined. Her platelet (pit) count, morphology, storage pool was normal. Bleeding time (Duke) was more than 15 min.PRP-aggregation (Ag) was normal when induced by PMA, whereas decreased (only primary Ag) by ADP, adrenalin, arachidonate (AA) (−2mM), Tx analog STA2 (−4μM), PAF (−10μM). Ag was defective in response to A23 (−40μM), Ag using wa
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Sekararum, Woro Ayu, Nurfitri Bustamam, Hikmah Muktamiroh, and Harli Amir Mahmudji. "The Correlation between Secretory Phospholipase A2 Type IIA Levels and Mean Platelet Volume among Type 2 Diabetes Mellitus Patients." In The 7th International Conference on Public Health 2020. Masters Program in Public Health, Universitas Sebelas Maret, 2020. http://dx.doi.org/10.26911/the7thicph.01.09.

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Background: Platelet activity plays a role in the occurrence of diabetic angiopathy with an increase in mean platelet volume (MPV) as a marker of platelet activity. Platelet activity is influenced by phospholipase A2 type IIA (sPLA2 type IIA), which is a lipid-mediating enzyme that connects the pathogenesis of Diabetes Mellitus (DM) with complications of diabetic angiopathy. This study aimed to examine the relationship between levels of type IIA sPLA2 and MPV among type II DM patients. Subjects and Method: This was a cross-sectional study. A total of 63 patients with type II DM was selected fo
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De Chaffoy de Courcells, D., and F. De Clerck. "THE EFFECT OF A COMBINED TXA2SYNTHETASE AND TXA2/PROSTAGLANDIN ENDOPEROXIDE RECEPTOR BLOCKER(R 68 070)ON THE ACTIVATION OF EXCITATORY RECEPTOR-COUPLEDPHOSPHOLIPASE C IN HUMAN PLATELETS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643758.

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Prostaglandin endoperoxides (PGEND) and thromboxane A2 (TxA2)contribute to the activation of platelets, involving inositol-containing phospholipids as a signal transducing system. A primary step in this signal transduction consists of the activation of phospholipase C, which then yields diacylglycerol and inositol phosphates;diacylglycerol is subsequently phosphorylated to phosphatidic acid (PA). In platelets prelabelled with [32P] orthophosphate,receptor activation is quantitatively reflected by an increased formation of [32P]-PA.Using this assay, the relativeimportance of endogenously genera
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Akkerman, JW N. "INTRACELLULAR PH CHANGES AND PLATELET ACTIVATION." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644774.

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It is long known that platelet aggregation and secretion are accompanied by acidification of the extracellular medium. Much of the proton extrusion results from hydrolysis of ATP generated in the glycolytic pathway and liberation of secretion granules, which are slightly acidic. Recent eyidence points at a third source for extracellular protons.Following early observations (1) that epinephrine-induced platelet functions depended on extracellular Na+ (Na+ o ), it became evident that platelets possess a Na+ /H+ antiport, which regulates the cytosolic pH (pH.) via stochiometric exchange of intrac
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