Relevant bibliographies by topics / Phosphoribosyltransferase

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Phosphoribosyltransferase'

Author: Grafiati
Published: 4 June 2021
Last updated: 4 February 2022

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Journal articles on the topic "Phosphoribosyltransferase"

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Fateev, Ilja V., Ekaterina V. Sinitsina, Aiguzel U. Bikanasova, Maria A. Kostromina, Elena S. Tuzova, Larisa V. Esipova, Tatiana I. Muravyova, Alexei L. Kayushin, Irina D. Konstantinova, and Roman S. Esipov. "Thermophilic phosphoribosyltransferases Thermus thermophilus HB27 in nucleotide synthesis." Beilstein Journal of Organic Chemistry 14 (December 21, 2018): 3098–105. http://dx.doi.org/10.3762/bjoc.14.289.

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Phosphoribosyltransferases are the tools that allow the synthesis of nucleotide analogues using multi-enzymatic cascades. The recombinant adenine phosphoribosyltransferase (TthAPRT) and hypoxanthine phosphoribosyltransferase (TthHPRT) from Thermus thermophilus HB27 were expressed in E.coli strains and purified by chromatographic methods with yields of 10–13 mg per liter of culture. The activity dependence of TthAPRT and TthHPRT on different factors was investigated along with the substrate specificity towards different heterocyclic bases. The kinetic parameters for TthHPRT with natural substra
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Aklujkar, Muktak. "Two ATP phosphoribosyltransferase isozymes of Geobacter sulfurreducens contribute to growth in the presence or absence of histidine and under nitrogen fixation conditions." Canadian Journal of Microbiology 57, no. 7 (July 2011): 547–58. http://dx.doi.org/10.1139/w11-047.

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Bacteria of the Geobacter clade possess two distinct ATP phosphoribosyltransferases encoded by hisGL and hisGS+hisZ to catalyze the first reaction of histidine biosynthesis. This very unusual redundancy was investigated by mutational analysis. The hisGL, hisGS, and hisZ genes of Geobacter sulfurreducens were deleted, effects on growth and histidine biosynthesis gene expression were evaluated, and deficiencies were complemented with plasmid-borne genes. Both hisGL and hisGS+hisZ encode functional ATP phosphoribosyltransferases. However, deletion of hisGL resulted in no growth defect, whereas de
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Sauer, Jørgen, and Per Nygaard. "Expression of the Methanobacterium thermoautotrophicum hpt Gene, Encoding Hypoxanthine (Guanine) Phosphoribosyltransferase, in Escherichia coli." Journal of Bacteriology 181, no. 6 (March 15, 1999): 1958–62. http://dx.doi.org/10.1128/jb.181.6.1958-1962.1999.

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ABSTRACT The hpt gene from the archaeon Methanobacterium thermoautotrophicum, encoding hypoxanthine (guanine) phosphoribosyltransferase, was cloned by functional complementation into Escherichia coli. The hpt-encoded amino acid sequence is most similar to adenine phosphoribosyltransferases, but the encoded enzyme has activity only with hypoxanthine and guanine. The synthesis of the recombinant enzyme is apparently limited by the presence of the rare arginine codons AGA and AGG and the rare isoleucine AUA codon on the hpt gene. The recombinant enzyme was purified to apparent homogeneity.
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Bollée, Guillaume, Jérôme Harambat, Albert Bensman, Bertrand Knebelmann, Michel Daudon, and Irène Ceballos-Picot. "Adenine Phosphoribosyltransferase Deficiency." Clinical Journal of the American Society of Nephrology 7, no. 9 (June 14, 2012): 1521–27. http://dx.doi.org/10.2215/cjn.02320312.

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Kadziola, A., K. S. Jensen, A. Mølgaard, J. C. N. Poulsen, and K. F. Jensen. "Sulfolobus solfataricusadenine phosphoribosyltransferase." Acta Crystallographica Section A Foundations of Crystallography 67, a1 (August 22, 2011): C786—C787. http://dx.doi.org/10.1107/s0108767311080093.

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Munagala, Narsimha, Anne E. Sarver, and Ching C. Wang. "Converting the Guanine Phosphoribosyltransferase fromGiardia lambliato a Hypoxanthine-guanine Phosphoribosyltransferase." Journal of Biological Chemistry 275, no. 47 (September 6, 2000): 37072–77. http://dx.doi.org/10.1074/jbc.m007239200.

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OLIVEIRA, DENILSON F., HELVÉCIO M. DOS SANTOS JÚNIOR, ALEXANDRO S. NUNES, VICENTE P. CAMPOS, RENATA S. C. DE PINHO, and GIOVANNA C. GAJO. "Purification and identification of metabolites produced by Bacillus cereus and B. subtilis active against Meloidogyne exigua, and their in silico interaction with a putative phosphoribosyltransferase fromM. incognita." Anais da Academia Brasileira de Ciências 86, no. 2 (June 2014): 525–38. http://dx.doi.org/10.1590/0001-3765201402412.

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To contribute to the development of products to controlMeloidogyne exigua, the bacteria Bacillus cereus and B. subtilis were cultivated in liquid medium to produce metabolites active against this plant-parasitic nematode. Fractionation of the crude dichloromethane extracts obtained from the cultures afforded uracil, 9H-purine and dihydrouracil. All compounds were active against M. exigua, the latter being the most efficient. This substance presented a LC50 of 204 µg/mL against the nematode, while a LC50 of 260 µg/mL was observed for the commercial nematicide carbofuran. A search for protein-li
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Jardim, Armando, Susan E. Bergeson, Sarah Shih, Nicola Carter, Randall W. Lucas, Gilles Merlin, Peter J. Myler, Kenneth Stuart, and Buddy Ullman. "Xanthine Phosphoribosyltransferase fromLeishmania donovani." Journal of Biological Chemistry 274, no. 48 (November 26, 1999): 34403–10. http://dx.doi.org/10.1074/jbc.274.48.34403.

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Pittelli, Maria, Laura Formentini, Giuseppe Faraco, Andrea Lapucci, Elena Rapizzi, Francesca Cialdai, Giovanni Romano, Gloriano Moneti, Flavio Moroni, and Alberto Chiarugi. "Inhibition of Nicotinamide Phosphoribosyltransferase." Journal of Biological Chemistry 285, no. 44 (August 19, 2010): 34106–14. http://dx.doi.org/10.1074/jbc.m110.136739.

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OLESEN, UFFE HØGH, NINA HASTRUP, and MAXWELL SEHESTED. "Expression patterns of nicotinamide phosphoribosyltransferase and nicotinic acid phosphoribosyltransferase in human malignant lymphomas." APMIS 119, no. 4-5 (March 25, 2011): 296–303. http://dx.doi.org/10.1111/j.1600-0463.2011.02733.x.

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Dissertations / Theses on the topic "Phosphoribosyltransferase"

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Catton, Gemma R. "Mechanistic studies on quinolinate phosphoribosyltransferase /." St Andrews, 2007. http://hdl.handle.net/10023/485.

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Catton, Gemma Rachel. "Mechanistic studies on quinolinate phosphoribosyltransferase." Thesis, University of St Andrews, 2008. http://hdl.handle.net/10023/485.

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Quinolinate phosphoribosyltransferase (QPRTase, EC 2.4.2.19) is an intriguing enzyme which appears to catalyse two distinct chemical reactions; transfer of a phosphoribosyl moiety from 5-phosphoribosyl-1-pyrophosphate to the nitrogen of quinolinic acid and decarboxylation at the 2-position to give nicotinic acid mononucleotide. The chemical mechanism of QPRTase is not fully understood. In particular, enzymatic involvement in the decarboxylation step is yet to be conclusively proven. QPRTase is neurologically important as it degrades the potent neurotoxin, quinolinic acid, implicated in disease
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Marinaki, Anthony Marin. "The biochemical and molecular basis of Hypoxanthine-guanine phosphoribosyltransferase deficiency." Doctoral thesis, University of Cape Town, 1996. http://hdl.handle.net/11427/26969.

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Hypoxanthine-guanine phosphoribosyltransferase (HPRT) catalyses the first step in purine salvage. A complete deficiency of the enzyme results in the devastating neurological symptoms of the Lesch-Nyhan syndrome. The Lesch-Nyhan syndrome is characterised by purine overproduction leading to, hyperuricemia and gout and a central nervous system disorder characterised by severe, spasticity, choreoathetosis, mental retardation and compulsive self-mutilatory behaviour, A partial deficiency of the enzyme results in purine overproduction, gout and occasionally, mild neurological symptoms. Patients are
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Murungi, Edwin Kimathi. "Purification and characterisation of plasmodium falciparum Hypoxanthine phosphoribosyltransferase." Thesis, University of the Western Cape, 2007. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_9199_1257245819.

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<p>Malaria remains the most important parasitic disease worldwide. It is estimated that over 500 million infections and more that 2.7 million deaths arising from malaria occur each year. Most (90%) of the infections occur in Africa with the most affected groups being children of less than five years of age and women. this dire situation is exacerbated by the emrggence of drug resistant strains of Plasmodium falciparum. The work reported in this thesis focuses on improving the purification of PfHPRT by investigating the characteristics of anion exchange DE-52 chromatography (the first stage of
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Ford, Barry Noel. "Structure-function relationships in Chinese hamster adenine phosphoribosyltransferase." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ34263.pdf.

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Shahabuddin, Mohammed. "Molecular studies on the hypoxanthine phosphoribosyltransferase of Plasmodium falciparum." Thesis, University of Edinburgh, 1990. http://hdl.handle.net/1842/14382.

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Hypoxanthine phosphoribosyltransferase (EC 2.7.2.8) of P.falciparum has been studied for its biological properties and cellular location. The enzyme plays an important role in the parasite's life, and therefore is a putative target for chemotherapy against malaria. Due to the difficulty in obtaining large amounts of the enzyme from the parasite, it was over-expressed in E.coli, first as a fusion protein with E.co/i-j8-galactosidase. This facilitated the one step purification of the protein, using /3-galactosidase substrate affinity chromatography, for making antibodies against the enzyme. The
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Mittelstädt, Gerd Horst. "Allosteric regulation of the adenosine triphosphate phosphoribosyltransferase from campylobacter jejuni." Thesis, University of Canterbury. Chemistry, 2015. http://hdl.handle.net/10092/10799.

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The enzyme adenosine triphosphate phosphoribosyltransferase (ATP-PRT) catalyses the first reaction of the histidine biosynthetic pathway. ATP-PRT also represents a metabolic control point, directing the flux of metabolites through this energetically expensive pathway. Two distinctly different forms of ATP-PRT exist, the long form and the short form, which differ in the presence of a C-terminal regulatory domain. In the short form, where this domain is absent, it is functionally replaced by a regulatory protein, called HisZ. ATP-PRT activity is modulated by two layers of regulation: active site
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Evans, Laura. "Investigating the role of nicotinamide phosphoribosyltransferase (NAMPT) in cartilage catabolism." Thesis, Cardiff University, 2013. http://orca.cf.ac.uk/58335/.

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NAMPT (nicotinamide phosphoribosyltransferase) is a universally expressed protein elevated in the serum and synovial fluid of rheumatoid arthritis (RA) sufferers. NAMPT is a rate-limiting enzyme in the biosynthesis of (nicotinamide adenine dinucleotide) NAD+, an essential cellular coenzyme, and has also been shown to exert cytokine-like activities as a mediator of innate immunity. However little is currently known of the role of NAMPT in cartilage metabolism. In this thesis, the role and regulation of NAMPT was studied in a variety of model systems. Addition of exogenous (e)NAMPT to fibroblast
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Duckworth, Megan Jane Medical Sciences Faculty of Medicine UNSW. "Characterisation of the xanthineguanine phosphoribosyltransferase of helicobacter pylori as a potential therapeutic target." Publisher:University of New South Wales. Medical Sciences, 2008. http://handle.unsw.edu.au/1959.4/43418.

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Helicobacter pylori infects more than half of the global population and causes gastric disorders. The increasing development of antibiotic resistance by the bacterium continues to limit treatment options. The identification and characterisation of novel therapeutic targets are necessary for successful future treatment of the infection. One potential target for therapeutic intervention is the gpt gene encoded by hp0735 (jhp0672) in H. pylori strain 26695 (J99). This gene produces a putative xanthine-guanine phosphoribosyltransferase (XGPRTase), an enzyme of the purine salvage synthesis pathway
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Phehane, Vuyisile Ntosi. "The expression and drug targeting of parasitic hypoxanthine-guanine phosphoribosyltransferase (HGPRT)." Doctoral thesis, University of Cape Town, 2002. http://hdl.handle.net/11427/2701.

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Bibliography: leaves 231-243.<br>We have expressed and purified human, two forms of P. falciparum, and Toxoplasma gondii hypoxanthine-guanine phosphoribosyltransferase (HPRT) in E. coli using the pET expression system. The cDNA encoding the ORF of HPRT was amplified by PCR and transformed into E. coli cells using standard methods. Expression was induced by IPTG and reached about 13% of the total cell protein for all four proteins. The HPRTs were purified by nickel affinity chromatography most of the expressed protein could be isolated from the crude supernatant fraction in a soluble form. Huma
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Books on the topic "Phosphoribosyltransferase"

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Nelson, Aileen A. The significance of adenine phosphoribosyltransferase for DNA excision repair processes in friend erythrdeukaemia cells. [S.l: The Author], 1996.

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Renwick, Pamela Jean. Inter-individual variation in the molecular genetic architecture of the hypoxanthine phosphoribosyltransferase encoding region of man. Birmingham: University of Birmingham, 1996.

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Ceballos-Picot, Irène, and H. A. Jinnah. Disorders of Purine Metabolism Affecting Adults. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199972135.003.0042.

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Defects in some of the enzymes of purine metabolism are known to be associated with specific clinical disorders that may manifest at any age. Some of these disorders first present in adulthood, while many present earlier but go undiagnosed until adulthood. This chapter describes the disorders for which the metabolic basis is well characterized, in particular Lesch-Nyhan disease caused by a deficiency of hypoxanthine-guanine phosphoribosyltransferase (HPRT) and characterized by hyperuricemia, and variable motor and cognitive disability. Adenine phosphoribosyltransferase (APRT) deficiency is a n
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Book chapters on the topic "Phosphoribosyltransferase"

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Haubeck, H. D. "Adenin-Phosphoribosyltransferase." In Lexikon der Medizinischen Laboratoriumsdiagnostik, 1. Berlin, Heidelberg: Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-49054-9_94-1.

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Haubeck, H. D. "Adenin-Phosphoribosyltransferase." In Springer Reference Medizin, 25. Berlin, Heidelberg: Springer Berlin Heidelberg, 2019. http://dx.doi.org/10.1007/978-3-662-48986-4_94.

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Schomburg, Dietmar, and Dörte Stephan. "Adenine phosphoribosyltransferase." In Enzyme Handbook 12, 969–75. Berlin, Heidelberg: Springer Berlin Heidelberg, 1996. http://dx.doi.org/10.1007/978-3-642-61117-9_213.

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Schomburg, Dietmar, and Dörte Stephan. "Hypoxanthine phosphoribosyltransferase." In Enzyme Handbook 12, 977–83. Berlin, Heidelberg: Springer Berlin Heidelberg, 1996. http://dx.doi.org/10.1007/978-3-642-61117-9_214.

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Schomburg, Dietmar, and Dörte Stephan. "Uracil phosphoribosyltransferase." In Enzyme Handbook 12, 985–89. Berlin, Heidelberg: Springer Berlin Heidelberg, 1996. http://dx.doi.org/10.1007/978-3-642-61117-9_215.

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Schomburg, Dietmar, and Dörte Stephan. "Orotate phosphoribosyltransferase." In Enzyme Handbook 12, 991–96. Berlin, Heidelberg: Springer Berlin Heidelberg, 1996. http://dx.doi.org/10.1007/978-3-642-61117-9_216.

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Schomburg, Dietmar, and Dörte Stephan. "Nicotinate phosphoribosyltransferase." In Enzyme Handbook 12, 997–1001. Berlin, Heidelberg: Springer Berlin Heidelberg, 1996. http://dx.doi.org/10.1007/978-3-642-61117-9_217.

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Schomburg, Dietmar, and Dörte Stephan. "Nicotinamide phosphoribosyltransferase." In Enzyme Handbook 12, 1003–6. Berlin, Heidelberg: Springer Berlin Heidelberg, 1996. http://dx.doi.org/10.1007/978-3-642-61117-9_218.

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Schomburg, Dietmar, and Dörte Stephan. "ATP phosphoribosyltransferase." In Enzyme Handbook 12, 1023–27. Berlin, Heidelberg: Springer Berlin Heidelberg, 1996. http://dx.doi.org/10.1007/978-3-642-61117-9_222.

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Schomburg, Dietmar, and Dörte Stephan. "Anthranilate phosphoribosyltransferase." In Enzyme Handbook 12, 1029–33. Berlin, Heidelberg: Springer Berlin Heidelberg, 1996. http://dx.doi.org/10.1007/978-3-642-61117-9_223.

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Conference papers on the topic "Phosphoribosyltransferase"

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Travelli, Cristina, Sara Morlacchi, Antonio Caldarelli, Antonio Sica, and Armando A. Genazzani. "Abstract 1871: Targeting nicotinamide phosphoribosyltransferase (NAMPT) in cancer therapy." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-1871.

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Sivordova, L., J. Polyakova, Y. Akhverdyan, V. Kravtsov, N. Fofanova, and B. Zavodovsky. "AB1326 Nicotinamide phosphoribosyltransferase may be new factors contributing to osteoarthritis." In Annual European Congress of Rheumatology, EULAR 2018, Amsterdam, 13–16 June 2018. BMJ Publishing Group Ltd and European League Against Rheumatism, 2018. http://dx.doi.org/10.1136/annrheumdis-2018-eular.3064.

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Moreno-Vinasco, L., J. Messana, T. Mirzapoiazova, E. Chiang, M. Brown, P. Singleton, S. Sammani, J. Moitra, and J. Garcia. "Intracellular PBEF-Nicotinamide Phosphoribosyltransferase (NamPT) Activity Is Protective in VILI." In American Thoracic Society 2009 International Conference, May 15-20, 2009 • San Diego, California. American Thoracic Society, 2009. http://dx.doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a5564.

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Grolla, Ambra, Simone Torretta, Angela Amoruso, Giuseppe Orsomando, and Armando Genazzani. "Abstract 440: Nicotinamide phosphoribosyltransferase (NAMPT): a new cytokine in tumor progression." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-440.

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Gibson, Anna E., Arnulfo Mendoza, Lioubov Korotchkina, Olga Chernova, and Christine M. Heske. "Abstract 5477: Targeting nicotinamide phosphoribosyltransferase (NAMPT) with OT-82 in Ewing sarcoma." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-5477.

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Akhverdyan, Y., B. Zavodovsky, J. Polyakova, L. Seewordova, I. Zborovskaya, and T. Rogatkina. "AB0288 Laboratory markers of inflammation and serum nicotinamide phosphoribosyltransferase level in rheumatoid arthritis patients." In Annual European Congress of Rheumatology, 14–17 June, 2017. BMJ Publishing Group Ltd and European League Against Rheumatism, 2017. http://dx.doi.org/10.1136/annrheumdis-2017-eular.1958.

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Hocková, Dana, Antonín Holý, Michal Česnek, Ondřej Baszczyňski, Tomáš Tichý, Marcela Krečmerová, Zlatko Janeba, et al. "Acyclic nucleoside phosphonates as inhibitors of hypoxanthine-guanine-xanthine phosphoribosyltransferase: new anti-malarial chemotherapy leads." In XVth Symposium on Chemistry of Nucleic Acid Components. Prague: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2011. http://dx.doi.org/10.1135/css201112171.

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Baumgart, Joshua T., Christine Heske, Mindy I. Davis, Kelli Wilson, Xiaoha Zhang, Rajarshi Guha, Marc Ferrer, Arnulfo Mendoza, Craig J. Thomas, and Lee J. Helman. "Abstract 1930: Evaluating the effect of PARP inhibitors in combination with nicotinamide phosphoribosyltransferase inhibitors in Ewing sarcoma." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-1930.

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Okumura, Shunsuke, Takaaki Sasaki, and Yoshinobu Ohsaki. "Abstract 1770: A role of nicotinamide phosphoribosyltransferase in growth of KRAS mutant non-small cell lung cancer." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-1770.

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Okumura, Shunsuke, Yoshinori Minami, Satoshi Endoh, Takaaki Sasaki, Kazuhiro Satoh, Masahiro Kitada, and Yoshinobu Ohsaki. "Abstract 964: Nicotinamide phosphoribosyltransferase (Nampt) regulates growth of non-small cell lung cancer cells with c-Met overexpression." In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-964.

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Reports on the topic "Phosphoribosyltransferase"

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Sivordova, L. E., J. V. Polyakova, Y. R. Akhverdyan, E. V. Papichev, and B. V. Zavodovsky. LEVEL OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE AS PATHOGENETIC FACTORS CONTRIBUTING TO OSTEOARTHRITIS PROGRESSION. Планета, 2018. http://dx.doi.org/10.18411/978-5-907109-24-7-2018-xxxv-247-251.

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Jett, J. Pre-thymic somatic mutation leads to high mutant frequency at hypoxanthine-guanine phosphoribosyltransferase gene. Office of Scientific and Technical Information (OSTI), December 1994. http://dx.doi.org/10.2172/98640.

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Akhverdyan, Y. R., B. V. Zavodovsky, J. V. Polyakova, L. E. Seewordova, and O. D. Korolik. COMPARISON OF THE CONCENTRATION OF NICOTINAMIDE-PHOSPHORIBOSYLTRANSFERASE IN THE SERUM OF HEALTHY SUBJECTS AND PATIENTS WITH RHEUMATOID ARTHRITIS. Планета, 2018. http://dx.doi.org/10.18411/978-5-907109-24-7-2018-xxxiv-46-48.

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