Relevant bibliographies by topics / Phosphoscan

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  1. Journal articles
  2. Dissertations / Theses

Academic literature on the topic 'Phosphoscan'

Author: Grafiati
Published: 11 March 2023
Last updated: 31 July 2025

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Journal articles on the topic "Phosphoscan"

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Wan, Yunhu, Diane Cripps, Stefani Thomas, et al. "PhosphoScan: A Probability-Based Method for Phosphorylation Site Prediction Using MS2/MS3 Pair Information." Journal of Proteome Research 7, no. 7 (2008): 2803–11. http://dx.doi.org/10.1021/pr700773p.

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Marcondes, A. Mario Q., Li Xiang, Brian P. Milless та H. Joachim Deeg. "Identification of DJ-1/Park-7 as a Determinant of Tnfα-Induced and Stroma-Dependent Apoptosis in Leukemia Using Mass Spectometry and Phosphopetide Analysis." Blood 112, № 11 (2008): 1796. http://dx.doi.org/10.1182/blood.v112.11.1796.1796.

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Abstract The bone marrow microenvironment provides essential signals for the fate of normal hematopoietic and for leukemic cells. Contact with marrow stroma, which is part of the microenvironment, is generally thought to convey anti-apoptotic signals to (clonal) leukemia cells. Patients with low-grade myelodysplastic syndrome (MDS) early in the disease course show high rates of apoptosis in normal and clonal marrow cells, mediated by tumor necrosis factor alpha (TNFα) and other cytokines. As MDS advances and evolves to leukemia, clonal cells tend to become apoptosis resistant. We showed previo
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Marcondes, A. Mario, Xiang Li, Ted A. Gooley, Brian Milless та H. Joachim Deeg. "Identification of DJ-1/PARK-7 as a determinant of stroma-dependent and TNF-α–induced apoptosis in MDS using mass spectrometry and phosphopeptide analysis". Blood 115, № 10 (2010): 1993–2002. http://dx.doi.org/10.1182/blood-2009-08-236992.

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AbstractIn patients with myelodysplastic syndromes (MDS), apoptosis in hematopoietic cells is up-regulated in low-grade disease, whereas advanced disease is characterized by apoptosis resistance. We have shown that marrow stroma–derived signals convey sensitivity to tumor-necrosis-factor alpha (TNF-α)–mediated apoptosis in otherwise-resistant KG1a myeloid cells and CD34+ cells from MDS marrow. Here, we used a PhosphoScan proteomic liquid chromatography–mass spectrometry method to identify signals relevant for this effect. The transcription factor DJ-1/PARK-7 (DJ-1) was highly phosphorylated in
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Zorro Manrique, Soraya, Christopher Spencer, Ana Dominguez, et al. "Global targeting of MDSC escape mechanisms cures advanced 4T1 breast tumors (P2062)." Journal of Immunology 190, no. 1_Supplement (2013): 132.21. http://dx.doi.org/10.4049/jimmunol.190.supp.132.21.

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Abstract 4T1 is a metastatic breast cancer model with fulminant accumulation of MDSCs. Survival and function of MDSCs is often reported as STAT3-dependent, and STAT3 inhibitors such as sunitinib dramatically deplete 4T1 splenic MDSCs. Paradoxically, sunitinib fails to eradicate 4T1 intratumoral MDSCs or prevent tumor progression. We hypothesized that STAT3 activation is a consistent feature of splenic but not intratumoral MDSCs. PhosphoSTAT analyses of 4T1-bearers confirmed that splenic MDSCs of all Gr1 intensities were solely pSTAT3pos. In remarkable contrast, intratumoral Gr1high MDSCs large
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Prasad, Narayan, Brijesh Yadav, and Vinita Agrawal. "Higher Intragraft Granzyme-B+ and PhosphoSMAD-3+ Cell Staining Are Associated with Inflammatory Interstitial Fibrosis and Tubular Atrophy in Renal Allograft Recipients." Journal of the American Society of Nephrology 34, no. 11S (2023): 1152. http://dx.doi.org/10.1681/asn.20233411s11152b.

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Yadav, B., N. Prasad, V. Agrawal, M. Jain, and V. Agarwal. "WCN23-0779 Inflammatory interstitial fibrosis and tubular atrophy is associated with intragraft Granzyme-B+ immune cell infiltration and phosphoSMAD-3+ mediated signaling in renal transplant recipients." Kidney International Reports 8, no. 3 (2023): S402—S403. http://dx.doi.org/10.1016/j.ekir.2023.02.903.

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7

Dispenzieri, Angela, Keith C. Bible, Martha Q. Lacy, et al. "The Lack of Clinical Efficacy of Flavopiridol in Patients with Relapsed Refractory Myeloma." Blood 104, no. 11 (2004): 3461. http://dx.doi.org/10.1182/blood.v104.11.3461.3461.

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Abstract Purpose: Flavopiridol is a cyclin-dependent kinase inhibitor with preclinical activity against multiple myeloma cells in vitro and ex vivo. It can induce apoptosis in non-cycling human cell lines, including RPMI-8226, a myeloma cell line. Suggested mechanisms of cytotoxicity include down regulation of anti-apoptotic regulators, direct binding to duplex DNA, disruption of transcription factor/DNA binding, upregulation of p53, inhibition of transcription, and inhibition of angiogenesis. A Phase II multicenter trial was conducted to determine the activity of flavopiridol in patients with
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Hall, Anthony Peter, Annick Cauvin, Sherri Dudal, James Raymond, Petrina Rogerson та Jacquelin Jolette. "Case Studies Discussing the Pathology, Immunogenicity, and Proposed Mechanism of Toxicity of an Inhaled Anti-TGFβ Humanized Fab Antibody in Non-Human Primates and Mice". Toxicologic Pathology, 10 листопада 2020, 019262332096002. http://dx.doi.org/10.1177/0192623320960023.

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Treatment of nonhuman primates and mice with a humanized antigen-binding fragment (Fab) antibody (UCBFab) inhibiting transforming growth factor β via daily inhalation for up to 13 weeks resulted in low systemic exposure but high local exposure in the lung. Target engagement was demonstrated by reduced levels of signal transducers, phosphoSMAD and plasminogen activator inhibitor-1 in the bronchoalveolar lavage fluid (BALF). Treatment was associated with a high frequency and titer of antidrug antibodies, indicating high local immunogenicity, and local pathology within the lung and draining lymph
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9

Yadav, Brijesh, Narayan Prasad, Vinita Agrawal, Vikas Agarwal, and Manoj Jain. "#6727 INFLAMMATORY INTERSTITIAL FIBROSIS AND TUBULAR ATROPHY ARE ASSOCIATED WITH HIGHER EXPRESSION OF INTRAGRAFT GRANZYME-B+ AND PHOSPHOSMAD-3+ PROTEIN." Nephrology Dialysis Transplantation 38, Supplement_1 (2023). http://dx.doi.org/10.1093/ndt/gfad063c_6727.

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Abstract Background and Aims Inflammatory Interstitial fibrosis and tubular atrophy (i-IF/TA) is a prominent histological lesion reported in late biopsy and poorly associated with graft survival. Cytotoxic T cell secrets Granzyme-B, which cleaves cytoskeleton protein, and activates pro-IL-1β, and TGF-β into their active form, leading to inflammation, fibrosis, and the apoptosis in target cell. The association of Granzyme-B+ cytotoxic T cell and phospho-SMAD-3 expression has been not explored in i-IF/TA in depth. Therefore, in this study, we aimed to determine the circulating and intragraft pro
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Dissertations / Theses on the topic "Phosphoscan"

1

PIGHI, Chiara. "An integrated approach to the study of mantle cell lymphoma." Doctoral thesis, 2013. http://hdl.handle.net/11562/546350.

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La comprensione dei meccanismi molecolari delle malattie sta alla base della medicina moderna. Questo campo di ricerca è divenuto sempre più interdisciplinare negli anni, sfruttando tecniche sviluppate inizialmente in chimica, biologia sperimentale, immunologia, matematica, informatica etc.. e proprio recentemente, con l'avvento di tecnologie high-throughput, questo tipo di approccio è diventato più una necessità che un lusso. In questo progetto abbiamo utilizzato un approccio integrato per lo studio del linfoma a cellule del mantello (MCL). Nel tentativo di ottenere un quadro più completo, e
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