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Journal articles on the topic 'Photoacoustic Imaging (PAI)'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Yang, Xuanjin, and Liangzhong Xiang. "Photoacoustic imaging of prostate cancer." Journal of Innovative Optical Health Sciences 10, no. 04 (2017): 1730008. http://dx.doi.org/10.1142/s1793545817300087.

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Photoacoustic imaging (PAI), also known as optoacoustic imaging, is a rapidly growing imaging modality with potential in medical diagnosis and therapy monitoring. This paper focuses on the techniques of prostate PAI and its potential applications in prostate cancer detection. Transurethral light delivery combined with transrectal ultrasound detection overcomes light scattering in the surrounding tissue and provides optimal photoacoustic signals while minimizing invasiveness. While label-free PAI based on endogenous contrast has promising potential for prostate cancer detection, exogenous contr

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Liu, Yu Bin, Zhi Fang Li, Wen Ming Xie, Hui Li, Wei R. Chen, and Hai Yu Chen. "Feasibility Study of Photoacoustic Imaging for Monitoring Temperature in Photothermal Therapy." Advanced Materials Research 760-762 (September 2013): 872–75. http://dx.doi.org/10.4028/www.scientific.net/amr.760-762.872.

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Photothermal therapy relies on the principle of converting light energy into heat causing localized lesion destruction. For safe and effective treatment, it is necessary to monitor temperature diffusion in the boundaries of the irradiated region, to minimize damage to surrounding normal tissues. This paper gives a pilot study of the feasibility of photoacoustic imaging for monitoring temperature changes during photothermal therapy. The results showed that our system of photoacoustic imaging (PAI) can play the role of biosensor, for the photoacoustics signal amplitude depend on temperature of t

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Wang, Haoran, Yifei Ma, Hao Yang, Huabei Jiang, Yingtao Ding, and Huikai Xie. "MEMS Ultrasound Transducers for Endoscopic Photoacoustic Imaging Applications." Micromachines 11, no. 10 (2020): 928. http://dx.doi.org/10.3390/mi11100928.

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Photoacoustic imaging (PAI) is drawing extensive attention and gaining rapid development as an emerging biomedical imaging technology because of its high spatial resolution, large imaging depth, and rich optical contrast. PAI has great potential applications in endoscopy, but the progress of endoscopic PAI was hindered by the challenges of manufacturing and assembling miniature imaging components. Over the last decade, microelectromechanical systems (MEMS) technology has greatly facilitated the development of photoacoustic endoscopes and extended the realm of applicability of the PAI. As the k

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Jung, Doyoung, Suhyeon Park, Changho Lee, and Hyungwoo Kim. "Recent Progress on Near-Infrared Photoacoustic Imaging: Imaging Modality and Organic Semiconducting Agents." Polymers 11, no. 10 (2019): 1693. http://dx.doi.org/10.3390/polym11101693.

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Over the past few decades, the photoacoustic (PA) effect has been widely investigated, opening up diverse applications, such as photoacoustic spectroscopy, estimation of chemical energies, or point-of-care detection. Notably, photoacoustic imaging (PAI) has also been developed and has recently received considerable attention in bio-related or clinical imaging fields, as it now facilitates an imaging platform in the near-infrared (NIR) region by taking advantage of the significant advancement of exogenous imaging agents. The NIR PAI platform now paves the way for high-resolution, deep-tissue im

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Yoo, Su, Doyoung Jung, Jung-Joon Min, Hyungwoo Kim, and Changho Lee. "Biodegradable Contrast Agents for Photoacoustic Imaging." Applied Sciences 8, no. 9 (2018): 1567. http://dx.doi.org/10.3390/app8091567.

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Over the past twenty years, photoacoustics—also called optoacoustics—have been widely investigated and, in particular, extensively applied in biomedical imaging as an emerging modality. Photoacoustic imaging (PAI) detects an ultrasound wave that is generated via photoexcitation and thermoelastic expansion by a short nanosecond laser pulse, which significantly reduces light and acoustic scattering, more than in other typical optical imaging and renders high-resolution tomographic images with preserving high absorption contrast with deep penetration depth. In addition, PAI provides anatomical an

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Wang, Yuanmao, Yang Chen, Yongjian Zhao, and Siyu Liu. "Compressed Sensing for Biomedical Photoacoustic Imaging: A Review." Sensors 24, no. 9 (2024): 2670. http://dx.doi.org/10.3390/s24092670.

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Photoacoustic imaging (PAI) is a rapidly developing emerging non-invasive biomedical imaging technique that combines the strong contrast from optical absorption imaging and the high resolution from acoustic imaging. Abnormal biological tissues (such as tumors and inflammation) generate different levels of thermal expansion after absorbing optical energy, producing distinct acoustic signals from normal tissues. This technique can detect small tissue lesions in biological tissues and has demonstrated significant potential for applications in tumor research, melanoma detection, and cardiovascular

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Zhao, Zuomin, and Teemu Myllylä. "Recent Technical Progression in Photoacoustic Imaging—Towards Using Contrast Agents and Multimodal Techniques." Applied Sciences 11, no. 21 (2021): 9804. http://dx.doi.org/10.3390/app11219804.

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For combining optical and ultrasonic imaging methodologies, photoacoustic imaging (PAI) is the most important and successful hybrid technique, which has greatly contributed to biomedical research and applications. Its theoretical background is based on the photoacoustic effect, whereby a modulated or pulsed light is emitted into tissue, which selectively absorbs the optical energy of the light at optical wavelengths. This energy produces a fast thermal expansion in the illuminated tissue, generating pressure waves (or photoacoustic waves) that can be detected by ultrasonic transducers. Researc

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He, Cailing, Jiayuan Zhu, Huayue Zhang, Ruirui Qiao, and Run Zhang. "Photoacoustic Imaging Probes for Theranostic Applications." Biosensors 12, no. 11 (2022): 947. http://dx.doi.org/10.3390/bios12110947.

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Photoacoustic imaging (PAI), an emerging biomedical imaging technology, capitalizes on a wide range of endogenous chromophores and exogenous contrast agents to offer detailed information related to the functional and molecular content of diseased biological tissues. Compared with traditional imaging technologies, PAI offers outstanding advantages, such as a higher spatial resolution, deeper penetrability in biological tissues, and improved imaging contrast. Based on nanomaterials and small molecular organic dyes, a huge number of contrast agents have recently been developed as PAI probes for d

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Das, Avishek, Arthur C. M. V. Pereira, Anton A. Popov, et al. "Plasmonically enhanced two-photon absorption induced photoacoustic microscopy with laser-synthesized TiN nanoparticles." Applied Physics Letters 121, no. 8 (2022): 083701. http://dx.doi.org/10.1063/5.0101658.

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Combining photonic excitation and acoustic detection, photoacoustic imaging (PAI) presents one of the most promising noninvasive biomedical diagnostic modalities, but this technique still lacks efficient nano-sized contrast agents absorbing light in the region of relative tissue transparency (630–900 nm). Here, we explore the use of titanium nitride (TiN) nanoparticles (NPs) fabricated by methods of pulsed laser ablation in liquids as a contrast agent in PAI. When prepared in acetone, the NPs are spherical, have an average size of 25 nm, and exhibit a broad plasmonic absorption peak around 700

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Liu, Liming, and Huan Qin. "Photoacoustic molecular imaging with functional nanoparticles." Journal of Innovative Optical Health Sciences 10, no. 04 (2017): 1730004. http://dx.doi.org/10.1142/s179354581730004x.

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Photoacoustic imaging (PAI) breaks through the optical diffusion limit by making use of the PA effect. By converting incident photons into ultrasonic waves, PAI combines high contrast of optical imaging and high spatial resolution in depth tissue of ultrasound imaging in a single imaging modality. This imaging modality has now shown potential for molecular imaging, which enables visualization of biological processes with systemically introduced functional nanoparticles. In the current review, the potentials of different optical nanoprobes as PAI contrast agents were elucidated and discussed.

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Kim, Jiwoong, Seongwook Choi, Chulhong Kim, Jeesu Kim, and Byullee Park. "Review on Photoacoustic Monitoring after Drug Delivery: From Label-Free Biomarkers to Pharmacokinetics Agents." Pharmaceutics 16, no. 10 (2024): 1240. http://dx.doi.org/10.3390/pharmaceutics16101240.

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Photoacoustic imaging (PAI) is an emerging noninvasive and label-free method for capturing the vasculature, hemodynamics, and physiological responses following drug delivery. PAI combines the advantages of optical and acoustic imaging to provide high-resolution images with multiparametric information. In recent decades, PAI’s abilities have been used to determine reactivity after the administration of various drugs. This study investigates photoacoustic imaging as a label-free method of monitoring drug delivery responses by observing changes in the vascular system and oxygen saturation levels

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Liu, Huibin, Xiangyu Teng, Shuxuan Yu, Wenguang Yang, Tiantian Kong, and Tangying Liu. "Recent Advances in Photoacoustic Imaging: Current Status and Future Perspectives." Micromachines 15, no. 8 (2024): 1007. http://dx.doi.org/10.3390/mi15081007.

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Photoacoustic imaging (PAI) is an emerging hybrid imaging modality that combines high-contrast optical imaging with high-spatial-resolution ultrasound imaging. PAI can provide a high spatial resolution and significant imaging depth by utilizing the distinctive spectroscopic characteristics of tissue, which gives it a wide variety of applications in biomedicine and preclinical research. In addition, it is non-ionizing and non-invasive, and photoacoustic (PA) signals are generated by a short-pulse laser under thermal expansion. In this study, we describe the basic principles of PAI, recent advan

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Lei, Zhao, Yun Zeng, Xiaofen Zhang, Xiaoyong Wang, and Gang Liu. "Photoacoustic reporter genes for noninvasive molecular imaging and theranostics." Journal of Innovative Optical Health Sciences 13, no. 03 (2020): 2030005. http://dx.doi.org/10.1142/s1793545820300050.

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Noninvasive molecular imaging makes the observation and comprehensive understanding of complex biological processes possible. Photoacoustic imaging (PAI) is a fast evolving hybrid imaging technology enabling in vivo imaging with high sensitivity and spatial resolution in deep tissue. Among the various probes developed for PAI, genetically encoded reporters attracted increasing attention of researchers, which provide improved performance by acquiring images of a PAI reporter gene’s expression driven by disease-specific enhancers/promoters. Here, we present a brief overview of recent studies abo

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Yang, Xinmai, and Xueding Wang. "Photoacoustic non-human primate brain imaging." Journal of the Acoustical Society of America 152, no. 4 (2022): A226. http://dx.doi.org/10.1121/10.0016091.

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Non-human primates (NHPs) play significant roles in brain research because of the physiological similarities between humans and NHPs. Current functional brain imaging techniques for NHPs are difficult to meet the required high spatiotemporal resolution for behavior active NHPs. In this presentation, we review our initial study on evaluating the feasibility of photoacoustic imaging (PAI) for monitoring hemodynamic responses in the NHP brains due to various functional activities. PAI systems, including array-based photoacoustic computed tomography (PACT) system and photoacoustic microscopy (PAM)

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Manwar, Rayyan, Mohsin Zafar, and Qiuyun Xu. "Signal and Image Processing in Biomedical Photoacoustic Imaging: A Review." Optics 2, no. 1 (2020): 1–24. http://dx.doi.org/10.3390/opt2010001.

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Photoacoustic imaging (PAI) is a powerful imaging modality that relies on the PA effect. PAI works on the principle of electromagnetic energy absorption by the exogenous contrast agents and/or endogenous molecules present in the biological tissue, consequently generating ultrasound waves. PAI combines a high optical contrast with a high acoustic spatiotemporal resolution, allowing the non-invasive visualization of absorbers in deep structures. However, due to the optical diffusion and ultrasound attenuation in heterogeneous turbid biological tissue, the quality of the PA images deteriorates. T

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Rajab Bolookat, Eftekhar, Laurie J. Rich, Gyorgy Paragh, Oscar R. Colegio, Anurag K. Singh, and Mukund Seshadri. "Photoacoustic Imaging of Tattoo Inks: Phantom and Clinical Evaluation." Applied Sciences 10, no. 3 (2020): 1024. http://dx.doi.org/10.3390/app10031024.

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Photoacoustic imaging (PAI) is a novel hybrid imaging modality that provides excellent optical contrast with the spatial resolution of ultrasound in vivo. The method is widely being investigated in the clinical setting for diagnostic applications in dermatology. In this report, we illustrate the utility of PAI as a non-invasive tool for imaging tattoos. Ten different samples of commercially available tattoo inks were examined for their optoacoustic properties in vitro. In vivo PAI of an intradermal tattoo on the wrist was performed in a healthy human volunteer. Black/gray, green, violet, and b

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Windra Sari, Atika, Rini Widyaningrum, and Mitra yana. "Photoacoustic Imaging for Periodontal Disease Examination." Journal of Lasers in Medical Sciences 13 (September 11, 2022): e37. http://dx.doi.org/10.34172/jlms.2022.37.

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Introduction: After caries, periodontal tissue inflammation (periodontitis) is the most common oral health problem. Photoacoustic imaging (PAI) is a new technique that uses simple components such as a diode laser and a condenser microphone. This study aimed to evaluate the performance of a simple PAI system in periodontal disease imaging by using an animal model. Methods: Normal periodontal and periodontitis tissues were obtained from Sprague–Dawley rats categorized as the control group, treatment group 1 (7 days of periodontitis induction), treatment group 2 (11 days of periodontitis inductio

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Wang, Xueding, Xinmai Yang, and Xose Luis Dean-Ben. "Special Issue on Photoacoustic Tomography." Applied Sciences 9, no. 19 (2019): 4186. http://dx.doi.org/10.3390/app9194186.

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Zhang, Yuqian, Zerui Li, Ziqing Du, Jianming Pan, and Yanan Huang. "Multifunctional Upconversion Nanoparticles Transforming Photoacoustic Imaging: A Review." Nanomaterials 15, no. 14 (2025): 1074. https://doi.org/10.3390/nano15141074.

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Photoacoustic imaging (PAI) merges the high spatial resolution of optical methods with the deep tissue penetration provided by ultrasound, making it a valuable tool in biomedical imaging. In recent years, a diverse array of photoacoustic contrast agents, spanning both organic and inorganic materials, has been developed. Among them, upconversion nanoparticles (UCNPs) stand out as promising candidates due to their unique optical features, tunable absorption in the near-infrared I (NIR-I, 750–1350 nm) region, and strong potential for both imaging and treatment-related uses. This review discusses

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Merkes, Jean Michel, Leiming Zhu, Srishti Ballabh Bahukhandi, Magnus Rueping, Fabian Kiessling, and Srinivas Banala. "Photoacoustic Imaging Probes Based on Tetrapyrroles and Related Compounds." International Journal of Molecular Sciences 21, no. 9 (2020): 3082. http://dx.doi.org/10.3390/ijms21093082.

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Photoacoustic imaging (PAI) is a rapidly evolving field in molecular imaging that enables imaging in the depths of ultrasound and with the sensitivity of optical modalities. PAI bases on the photoexcitation of a chromophore, which converts the absorbed light into thermal energy, causing an acoustic pressure wave that can be captured with ultrasound transducers, in generating an image. For in vivo imaging, chromophores strongly absorbing in the near-infrared range (NIR; > 680 nm) are required. As tetrapyrroles have a long history in biomedical applications, novel tetrapyrroles and inspired m

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Chan, Jasmine, Zhou Zheng, Kevan Bell, Martin Le, Parsin Haji Reza, and John T. W. Yeow. "Photoacoustic Imaging with Capacitive Micromachined Ultrasound Transducers: Principles and Developments." Sensors 19, no. 16 (2019): 3617. http://dx.doi.org/10.3390/s19163617.

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Photoacoustic imaging (PAI) is an emerging imaging technique that bridges the gap between pure optical and acoustic techniques to provide images with optical contrast at the acoustic penetration depth. The two key components that have allowed PAI to attain high-resolution images at deeper penetration depths are the photoacoustic signal generator, which is typically implemented as a pulsed laser and the detector to receive the generated acoustic signals. Many types of acoustic sensors have been explored as a detector for the PAI including Fabry–Perot interferometers (FPIs), micro ring resonator

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Zafar, Mohsin, Amanda P. Siegel, Kamran Avanaki, and Rayyan Manwar. "Skin Imaging Using Optical Coherence Tomography and Photoacoustic Imaging: A Mini-Review." Optics 5, no. 2 (2024): 248–66. http://dx.doi.org/10.3390/opt5020018.

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This article provides an overview of the progress made in skin imaging using two emerging imaging modalities, optical coherence tomography (OCT) and photoacoustic imaging (PAI). Over recent years, these technologies have significantly advanced our understanding of skin structure and function, offering non-invasive and high-resolution insights previously unattainable. The review begins by briefly describing the fundamental principles of how OCT and PAI capture images. It then explores the evolving applications of OCT in dermatology, ranging from diagnosing skin disorders to monitoring treatment

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Wu, Yun, Dan Wu, Yanting Wen, et al. "Photoacoustic Imaging in Visualization of Acupuncture Mechanisms." Photonics 12, no. 4 (2025): 365. https://doi.org/10.3390/photonics12040365.

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Photoacoustic imaging (PAI) has emerged as a transformative modality for bridging traditional Chinese medicine (TCM) theory and contemporary biomedical research in acupuncture mechanism studies. This review assesses PAI’s capacity to decode acupuncture-induced neuromodulatory and hemodynamic effects, with dual focus on the central nervous system (CNS) responses and acupoint-specific microcirculatory dynamics. Leveraging the photoacoustic effect coupled with ultrasonic detection, PAI enables non-invasive, high-resolution mapping of cerebral hemodynamic parameters, including blood flow, oxygen s

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Jeong, Songah, Su Woong Yoo, Hea Ji Kim, et al. "Recent Progress on Molecular Photoacoustic Imaging with Carbon-Based Nanocomposites." Materials 14, no. 19 (2021): 5643. http://dx.doi.org/10.3390/ma14195643.

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For biomedical imaging, the interest in noninvasive imaging methods is ever increasing. Among many modalities, photoacoustic imaging (PAI), which is a combination of optical and ultrasound imaging techniques, has received attention because of its unique advantages such as high spatial resolution, deep penetration, and safety. Incorporation of exogenous imaging agents further amplifies the effective value of PAI, since they can deliver other specified functions in addition to imaging. For these agents, carbon-based materials can show a large specific surface area and interesting optoelectronic

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Kothapalli, Sri-Rajasekhar, Geoffrey A. Sonn, Jung Woo Choe, et al. "Simultaneous transrectal ultrasound and photoacoustic human prostate imaging." Science Translational Medicine 11, no. 507 (2019): eaav2169. http://dx.doi.org/10.1126/scitranslmed.aav2169.

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Imaging technologies that simultaneously provide anatomical, functional, and molecular information are emerging as an attractive choice for disease screening and management. Since the 1980s, transrectal ultrasound (TRUS) has been routinely used to visualize prostatic anatomy and guide needle biopsy, despite limited specificity. Photoacoustic imaging (PAI) provides functional and molecular information at ultrasonic resolution based on optical absorption. Combining the strengths of TRUS and PAI approaches, we report the development and bench-to-bedside translation of an integrated TRUS and photo

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Liu, Yijing, Pravin Bhattarai, Zhifei Dai, and Xiaoyuan Chen. "Photothermal therapy and photoacoustic imaging via nanotheranostics in fighting cancer." Chemical Society Reviews 48, no. 7 (2019): 2053–108. http://dx.doi.org/10.1039/c8cs00618k.

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Fang, Yousong, Ting Feng, Chenyin Ni, Chengcheng Liu, and Qian Cheng. "The Feasibility Study of Bone Fracture Assessment Based on Photoacoustic Time-of-Flight Method." Journal of Physics: Conference Series 2822, no. 1 (2024): 012038. http://dx.doi.org/10.1088/1742-6596/2822/1/012038.

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Abstract Photoacoustic imaging (PAI) technology combines the advantages of acoustic resolution and optical contrast imaging within deep tissue. The commonly clinically used bone fracture detection and evaluation method is X-ray based imaging techniques. In order to study the feasibility of human radius fractures detection in non-radiation and non-invasive way, this study combined the time-of-flight (TOF) method commonly used in industrial nondestructive testing with photoacoustic technology for the detection and location of bone fractures. Firstly, the bone fracture information carried by PA s

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Prud’homme, Alberto, and Frederic Nabki. "Cost-Effective Photoacoustic Imaging Using High-Power Light-Emitting Diodes Driven by an Avalanche Oscillator." Sensors 25, no. 6 (2025): 1643. https://doi.org/10.3390/s25061643.

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Photoacoustic imaging (PAI) is an emerging modality that merges optical and ultrasound imaging to provide high-resolution and functional insights into biological tissues. This technique leverages the photoacoustic effect, where tissue absorbs pulsed laser light, generating acoustic waves that are captured to reconstruct images. While lasers have traditionally been the light source for PAI, their high cost and complexity drive interest towards alternative sources like light-emitting diodes (LEDs). This study evaluates the feasibility of using an avalanche oscillator to drive high-power LEDs in

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Yang, Huan, Xili Jing, Zhiyong Yin, Shuoyu Chen, and Chun Wang. "A Method to Obtain the Transducers Impulse Response (TIR) in Photoacoustic Imaging." Applied Sciences 14, no. 2 (2024): 920. http://dx.doi.org/10.3390/app14020920.

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Photoacoustic tomography (PAT) is an emerging imaging technique with great potential for a wide range of biomedical imaging applications. The transducers impulse response (TIR) is a key factor affecting the performance of photoacoustic imaging (PAI). It is customary in PAI to assume that TIR is known or obtain it from experiments. In this paper, we investigate the possibility of obtaining TIR in another way. A new method is proposed to extract TIR from observed optoacoustic signal (OPAS) data, without prior knowledge, as a known condition. It is based on the relation between the OPAS data and

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Men, Xiaoju, and Zhen Yuan. "Multifunctional conjugated polymer nanoparticles for photoacoustic-based multimodal imaging and cancer photothermal therapy." Journal of Innovative Optical Health Sciences 12, no. 03 (2019): 1930001. http://dx.doi.org/10.1142/s1793545819300015.

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Photoacoustic imaging (PAI) is a hybrid imaging method based on photoacoustic (PA) effects, which is able to capture the structure, function, and molecular information of biological tissues with high resolution. To date, therapeutic techniques under the guidance of PAI have provided new strategies for accurate diagnosis and precise treatment of tumors. In particular, conjugated polymer nanoparticles have been extensively inspected for PA-based cancer theranostics largely due to their superior optical properties such as tunable spectrum and large absorption coefficient and their good biocompati

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Ying, Yue, Hong Zhang, and Li Lin. "Photoacoustic Imaging of Human Skin for Accurate Diagnosis and Treatment Guidance." Optics 5, no. 1 (2024): 133–50. http://dx.doi.org/10.3390/opt5010010.

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Photoacoustic imaging (PAI) is a cutting-edge biomedical imaging modality, providing detailed anatomical and functional information about the area beneath the skin surface. Its light energy deposition is such that PAI typically provides clear images of the skin with high signal-to-noise ratios. Specifically, the rich optical contrast of PAI allows biological information related to lesion growth, malignancy, treatment response, and prognosis to be seen. Given its significant advantages and emerging role in imaging skin lesions, we summarize and comment on representative studies of skin PAI, suc

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Zhang, Ying, Ning Zhao, Yeshan Qin, et al. "Affibody-functionalized Ag2S quantum dots for photoacoustic imaging of epidermal growth factor receptor overexpressed tumors." Nanoscale 10, no. 35 (2018): 16581–90. http://dx.doi.org/10.1039/c8nr02556h.

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Photoacoustic imaging (PAI) is a new and attractive imaging modality, and it has strong potential for application in the early detection of tumors through the use of optically absorbing targeted contrast agents.

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Wang, Fei, Xiaoju Men, Haobin Chen, et al. "Second near-infrared photoactivatable biocompatible polymer nanoparticles for effective in vitro and in vivo cancer theranostics." Nanoscale 13, no. 31 (2021): 13410–20. http://dx.doi.org/10.1039/d1nr03156b.

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Dai, Yeneng, Wenyu Du, Diya Gao, et al. "Near-infrared-II light excitation thermosensitive liposomes for photoacoustic imaging-guided enhanced photothermal-chemo synergistic tumor therapy." Biomaterials Science 10, no. 2 (2022): 435–43. http://dx.doi.org/10.1039/d1bm01669e.

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Gargiulo, Sara, Sandra Albanese, and Marcello Mancini. "State-of-the-Art Preclinical Photoacoustic Imaging in Oncology: Recent Advances in Cancer Theranostics." Contrast Media & Molecular Imaging 2019 (April 30, 2019): 1–24. http://dx.doi.org/10.1155/2019/5080267.

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The optical imaging plays an increasing role in preclinical studies, particularly in cancer biology. The combined ultrasound and optical imaging, named photoacoustic imaging (PAI), is an emerging hybrid technique for real-time molecular imaging in preclinical research and recently expanding into clinical setting. PAI can be performed using endogenous contrast, particularly from oxygenated and deoxygenated hemoglobin and melanin, or exogenous contrast agents, sometimes targeted for specific biomarkers, providing comprehensive morphofunctional and molecular information on tumor microenvironment.

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Lee, Changho, Jin Kim, and Chulhong Kim. "Recent Progress on Photoacoustic Imaging Enhanced with Microelectromechanical Systems (MEMS) Technologies." Micromachines 9, no. 11 (2018): 584. http://dx.doi.org/10.3390/mi9110584.

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Photoacoustic imaging (PAI) is a new biomedical imaging technology currently in the spotlight providing a hybrid contrast mechanism and excellent spatial resolution in the biological tissues. It has been extensively studied for preclinical and clinical applications taking advantage of its ability to provide anatomical and functional information of live bodies noninvasively. Recently, microelectromechanical systems (MEMS) technologies, particularly actuators and sensors, have contributed to improving the PAI system performance, further expanding the research fields. This review introduces cutti

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Seong, Daewoon, Sangyeob Han, Jaeyul Lee, et al. "Waterproof Galvanometer Scanner-Based Handheld Photoacoustic Microscopy Probe for Wide-Field Vasculature Imaging In Vivo." Photonics 8, no. 8 (2021): 305. http://dx.doi.org/10.3390/photonics8080305.

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Photoacoustic imaging (PAI) is a hybrid non-invasive imaging technique used to merge high optical contrast and high acoustic resolution in deep tissue. PAI has been extensively developed by utilizing its advantages that include deep imaging depth, high resolution, and label-free imaging. As a representative implementation of PAI, photoacoustic microscopy (PAM) has been used in preclinical and clinical studies for its micron-scale spatial resolution capability with high optical absorption contrast. Several handheld and portable PAM systems have been developed that improve its applicability to s

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Bolookat, Eftekhar Rajab, Vui King Vincent-Chong, Laurie J. Rich, Anurag K. Singh, and Mukund Seshadri. "Ultrasound-Guided Photoacoustic Imaging of Salivary Gland Hemodynamics in Rabbits." Photonics 11, no. 3 (2024): 273. http://dx.doi.org/10.3390/photonics11030273.

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Xerostomia (severe dry mouth) is a debilitating and often permanent side effect experienced by head and neck cancer patients due to radiation injury to salivary glands. In this study, we evaluated the potential of ultrasound (US)-guided photoacoustic imaging (PAI) to non-invasively assess early changes in salivary gland hemodynamics following radiation therapy (RT). US-guided PAI was performed in New Zealand white rabbits to visualize and quantify the hemoglobin concentration (HbT) and oxygen saturation (%sO2) of parotid glands before and after RT. The imaging findings were validated with hist

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Sivasubramanian, Maharajan, and Leu-Wei Lo. "Assessment of Nanoparticle-Mediated Tumor Oxygen Modulation by Photoacoustic Imaging." Biosensors 12, no. 5 (2022): 336. http://dx.doi.org/10.3390/bios12050336.

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Photoacoustic imaging (PAI) is an invaluable tool in biomedical imaging, as it provides anatomical and functional information in real time. Its ability to image at clinically relevant depths with high spatial resolution using endogenous tissues as contrast agents constitutes its major advantage. One of the most important applications of PAI is to quantify tissue oxygen saturation by measuring the differential absorption characteristics of oxy and deoxy Hb. Consequently, PAI can be utilized to monitor tumor-related hypoxia, which is a crucial factor in tumor microenvironments that has a strong

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Godefroy, Guillaume, Bastien Arnal, and Emmanuel Bossy. "Multispectral photoacoustic fluctuation imaging for full visibility SO₂ imaging." Journal of the Acoustical Society of America 152, no. 4 (2022): A225. http://dx.doi.org/10.1121/10.0016088.

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Photoacoustic (PA) imaging (PAI) images blood vessels through the hemoglobin contrast. However, conventional images are affected by visibility artefacts which prevents seeing all the blood vessels morphology. We introduced PA fluctuation imaging (PAFI) exploiting the absorption fluctuations due to blood flow. Here, we demonstrate how PAFI enhances the image quality and elaborate if it can be used for quantitative multispectral (MS) imaging for 3D blood oxygenation (SO2) imaging. A spherical array (256 elements, 8 MHz, Imasonic) connected to a Verasonics Vantage scanner, was coupled to the lase

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Suzuki, Yushi, Hiroki Kajita, Marika Otaki, et al. "Comparison of the Quality of Lymphatic Vessel Images Obtained Using Two Photoacoustic Imaging Systems." Plastic and Reconstructive Surgery - Global Open 12, no. 12 (2024): e6388. https://doi.org/10.1097/gox.0000000000006388.

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Summary: Photoacoustic imaging (PAI) can evaluate lymphatic vessels with a high resolution (0.2 mm) compared with other methods. LUB0, a new PAI device that is smaller than the PAI-05 used since 2020 (both from Luxonus, Inc.), has been introduced. We aimed to determine the imaging capability of LUB0 by comparing it with that of PAI-05. Two healthy individuals and 4 patients with lymphedema underwent PAI using PAI-05 and LUB0. Each participant was subcutaneously injected with indocyanine green to visualize the lymphatic vessels. PAI was performed after confirming that the lymphatic flow had mov

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Liu, Xueyan, Dong Peng, Wei Guo, Xibo Ma, Xin Yang, and Jie Tian. "Compressed Sensing Photoacoustic Imaging Based on Fast Alternating Direction Algorithm." International Journal of Biomedical Imaging 2012 (2012): 1–7. http://dx.doi.org/10.1155/2012/206214.

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Photoacoustic imaging (PAI) has been employed to reconstruct endogenous optical contrast present in tissues. At the cost of longer calculations, a compressive sensing reconstruction scheme can achieve artifact-free imaging with fewer measurements. In this paper, an effective acceleration framework using the alternating direction method (ADM) was proposed for recovering images from limited-view and noisy observations. Results of the simulation demonstrated that the proposed algorithm could perform favorably in comparison to two recently introduced algorithms in computational efficiency and data

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Vaiyapuri, Thavavel, Ashit Kumar Dutta, Mohamed Yacin Sikkandar, et al. "Design of Metaheuristic Optimization-Based Vascular Segmentation Techniques for Photoacoustic Images." Contrast Media & Molecular Imaging 2022 (January 30, 2022): 1–12. http://dx.doi.org/10.1155/2022/4736113.

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Biomedical imaging technologies are designed to offer functional, anatomical, and molecular details related to the internal organs. Photoacoustic imaging (PAI) is becoming familiar among researchers and industrialists. The PAI is found useful in several applications of brain and cancer imaging such as prostate cancer, breast cancer, and ovarian cancer. At the same time, the vessel images hold important medical details which offer strategies for a qualified diagnosis. Recently developed image processing techniques can be employed to segment vessels. Since vessel segmentation on PAI is a difficu

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Han, Moongyu, Wonseok Choi, Joongho Ahn, Hanyoung Ryu, Youngseok Seo, and Chulhong Kim. "In Vivo Dual-Modal Photoacoustic and Ultrasound Imaging of Sentinel Lymph Nodes Using a Solid-State Dye Laser System." Sensors 20, no. 13 (2020): 3714. http://dx.doi.org/10.3390/s20133714.

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Photoacoustic imaging (PAI) is being actively investigated as a non-invasive and non-radioactive imaging technique for sentinel lymph node (SLN) biopsy. By taking advantage of optical and ultrasound imaging, PAI probes SLNs non-invasively with methylene blue (MB) in both live animals and breast cancer patients. However, these PAI systems have limitations for widespread use in clinics and commercial marketplaces because the lasers used by the PAI systems, e.g., tunable liquid dye laser systems and optical parametric oscillator (OPO) lasers, are bulky in size, not economical, and use risky flamm

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SUN, MINGJIAN, NAIZHANG FENG, YI SHEN, XIANGLI SHEN, and JIANGANG LI. "PHOTOACOUSTIC SIGNALS DENOISING BASED ON EMPIRICAL MODE DECOMPOSITION AND ENERGY-WINDOW METHOD." Advances in Adaptive Data Analysis 04, no. 01n02 (2012): 1250004. http://dx.doi.org/10.1142/s1793536912500045.

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In the process of photoacoustic imaging (PAI), the photoacoustic signals are polluted by a strong background white noise, which is caused by many factors such as the system thermal noise or short noise, the tissue reflecting or scattering interference, and the impedance match lack between the transducer and tissue. The inevitable noise can degrade the contrast sensitivity of photoacoustic images seriously. In this paper, based on the energy window, a CMSE-EMD denoising method is employed to photoacoustic image reconstruction. Results of the simulation demonstrate that it can eliminate the imag

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Zhao, Chenyang, Rui Zhang, Qinli Zhu, Ming Wang, Meng Yang, and Yuxin Jiang. "The potential of photoacoustic techniques in inflammatory arthritis: what can it do to assist conventional imaging methods?" Chinese Journal of Academic Radiology 4, no. 2 (2021): 79–87. http://dx.doi.org/10.1007/s42058-021-00066-2.

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AbstractTo make comprehensive assessments of some rheumatoid diseases, a more reliable imaging method for evaluating joint lesions is required. Photoacoustic imaging (PAI) is a state-of-the-art imaging technique, providing new options for diagnosing joint disease. In light of the recent preclinical studies, detailed morphological structures and micro-vessels of small joints, especially the finger joints, could be visualized by PAI with high spatial resolution and optical contrast using different PA implementations. By measuring the signals of oxygenated and deoxygenated hemoglobin through dual

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Maturi, Mirko, Erica Locatelli, Ilaria Monaco, and Mauro Comes Franchini. "Current concepts in nanostructured contrast media development for in vivo photoacoustic imaging." Biomaterials Science 7, no. 5 (2019): 1746–75. http://dx.doi.org/10.1039/c8bm01444b.

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To overcome the endogenous photoacoustic contrast arising from endogenous species, specific contrast agents need to be developed, allowing PAI to successfully identify targeted contrast in the range of wavelength in which the interference from the biomatrix is minimized.

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Zhou, Gaoxin, Ying Shuai Wang, Zhaokui Jin, et al. "Porphyrin–palladium hydride MOF nanoparticles for tumor-targeting photoacoustic imaging-guided hydrogenothermal cancer therapy." Nanoscale Horizons 4, no. 5 (2019): 1185–93. http://dx.doi.org/10.1039/c9nh00021f.

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A nanoscale porphyrin–palladium metal–organic framework (Pd-MOF) with highly dispersive Pd atoms as hydrogen carrier was developed to efficiently load highly reductive hydrogen for the tumor-targeted photoacoustic imaging (PAI)-guided hydrogenothermal therapy of cancer.

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Chen, Yi, Yufei Jiang, Ruonan He, et al. "Adaptive Detection and Classification of Brain Tumour Images Based on Photoacoustic Imaging." Applied Sciences 14, no. 12 (2024): 5270. http://dx.doi.org/10.3390/app14125270.

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A new imaging technique called photoacoustic imaging (PAI) combines the advantages of ultrasound imaging and optical absorption to provide structural and functional details of tissues. It has broad application prospects in the accurate diagnosis and treatment monitoring of brain tumours. However, the existing photoacoustic image classification algorithms cannot effectively distinguish benign tumours from malignant tumours. To address this problem, the YoLov8-MedSAM model is proposed in this research to provide precise and adaptable brain tumour identification and detection segmentation. Additi

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Kratkiewicz, Karl, Rayyan Manwar, Mohsin Zafar, et al. "Development of a Stationary 3D Photoacoustic Imaging System Using Sparse Single-Element Transducers: Phantom Study." Applied Sciences 9, no. 21 (2019): 4505. http://dx.doi.org/10.3390/app9214505.

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Photoacoustic imaging (PAI) is an emerging label-free and non-invasive modality for imaging biological tissues. PAI has been implemented in different configurations, one of which is photoacoustic computed tomography (PACT) with a potential wide range of applications, including brain and breast imaging. Hemispherical Array PACT (HA-PACT) is a variation of PACT that has solved the limited detection-view problem. Here, we designed an HA-PACT system consisting of 50 single element transducers. For implementation, we initially performed a simulation study, with parameters close to those in practice

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