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Journal articles on the topic 'Photodynamic treatment'

Author: Grafiati

Published: 4 June 2021

Last updated: 21 February 2023

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1

Poljacki, Mirjana, Marina Jovanovic, Ljubinka Matovic, Branislava Lugonja, Branislava Gajic, and Tatjana Ros. "Topical photodynamic therapy." Archive of Oncology 14, no. 1-2 (2006): 39–44. http://dx.doi.org/10.2298/aoo0602039p.

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Topical photodynamic therapy is a therapeutic modality in development, thus arises grate interest among dermatologists worldwide. It is an effective therapy for actinic keratosis, superficial BCC and Bowenos disease. Treatment efficacy, good cosmetics, low risk of skin cancer, low invasiveness, low rate of adverse events, facility for treating multiple or large lesions, especially in poor healing sites and, for penile, digital and facial involvement, low general toxicity and possibility of repeating the treatments with the same efficiency, enable topical photodynamic therapy to become increasingly practiced treatment modality. Researching aimed topical photodynamic therapy to prove as a treatment modality for clinical use in other dermatoses, is in experimental phase. To answer the question when dermatologist should consider using topical photodynamic therapy treatment modatility, we are present available date.

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Sazhnev, Dmitrii Igorevich, Alexandr Alexeevich Andreev, and Alexandr Anatol'evich Glukhov. "Photodynamic therapy." Journal of Experimental and Clinical Surgery 12, no. 2 (March 29, 2019): 141–46. http://dx.doi.org/10.18499/2070-478x-2019-12-2-141-146.

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The article presents data on the high-tech method of treatment-photodynamic therapy (PDT). An overview of the history of the use of photochemical reaction in the treatment of patients is given. The mechanisms of therapeutic action of PDT, the advantages of the method in comparison with other methods of antimicrobial action are described in detail; the indications and contraindications for this method of treatment are given. The article lists used for PDT photosensitizers of different generations and laser devices capable of emitting laser radiation of the required wavelength. The overview contains information about the efficiency of the method of PDT with certain diseases. Based on the literature review, it is concluded that PDT is a modern and promising method of treatment that can significantly improve the quality of care for patients with various diseases, which are based on cell proliferation. The proven effectiveness of the method of photodynamic therapy and its advantage over other antimicrobial treatments demonstrate the relevance of its wider introduction into clinical practice.

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3

Manyak, M. J., A. Russo, P. D. Smith, and E. Glatstein. "Photodynamic therapy." Journal of Clinical Oncology 6, no. 2 (February 1988): 380–91. http://dx.doi.org/10.1200/jco.1988.6.2.380.

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Photodynamic therapy (PDT) is an experimental cancer treatment modality that selectively destroys cancer cells by an interaction between absorbed light and a retained photosensitizing agent. This review discusses the basic components of photodynamic activity and examines the clinical applications of photodynamic therapy in cancer treatment. Treatment of superficial and early-stage malignancies is encouraging. Technologic advancement and further elucidation of the fundamental basis of photodynamic action should permit treatment of more advanced malignancies.

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4

Huang, Zheng. "A Review of Progress in Clinical Photodynamic Therapy." Technology in Cancer Research & Treatment 4, no. 3 (June 2005): 283–93. http://dx.doi.org/10.1177/153303460500400308.

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Photodynamic therapy (PDT) has received increased attention since the regulatory approvals have been granted to several photosensitizing drugs and light applicators worldwide. Much progress has been seen in basic sciences and clinical photodynamics in recent years. This review will focus on new developments of clinical investigation and discuss the usefulness of various forms of PDT techniques for curative or palliative treatment of malignant and non-malignant diseases.

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Hasan Zeynalova, Jala, Gulnara Salam Mammedova, Gunel Mammad Sultanova, İrada Arif Mammedxanova, Sevda Tariyel Huseynova, and Shahla Rafael Yusubova. "TREATMENT OF ORAL LICHEN PLANUS LICHEN PLANUS WITH PHOTODYNAMIC THERAPY." NATURE AND SCIENCE 14, no. 09 (November 23, 2021): 10–13. http://dx.doi.org/10.36719/2707-1146/14/10-13.

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Ağız boşluğunda yastı dəmirovun meydana gəlməsi ilə bağlı irəli sürülən bir sıra nəzəriyyələrə baxmayaraq, bu növ allergiya polietioloji hesab olunur.Ağız boşluğunun qırmızı yastı dəmirovu bir insandan digərinə keçə bilməz. Xəstəlik immun sisteminin naməlum səbəblərdən ağızın selikli qişasında hüceyrələrin strukturunun pozulması nəticəsində baş verir. Simptomlar adətən müalicə olunur, lakin ağızda qırmızı yastı dəmirovu olan insanlar mütəmadi həkim konsultasiyasına ehtiyac duyurlar. Açar sözlər: ağız boşluğunun qırmızı yastı dəmirovu, fotodinamik terapiya, metilen abısı

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Giovannini, A., P. Neri, L. Mercanti, and C. Brue. "Photodynamic treatment versus photodynamic treatment associated with systemic steroids for idiopathic choroidal neovascularisation." British Journal of Ophthalmology 91, no. 5 (January 3, 2007): 620–23. http://dx.doi.org/10.1136/bjo.2006.103135.

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7

Zhao, Tianyuan, Jungyul Song, Yuzhuo Ping, and Meihua Li. "The Application of Antimicrobial Photodynamic Therapy (aPDT) in the Treatment of Peri-Implantitis." Computational and Mathematical Methods in Medicine 2022 (May 12, 2022): 1–8. http://dx.doi.org/10.1155/2022/3547398.

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Background. This literature review evaluates the mechanisms and efficacy of different types of antimicrobial photodynamic therapy (aPDT) for treating peri-implantitis by reviewing existing experimental studies to provide guidance for the clinical application of antibacterial photodynamic therapy (aPDT) in oral implants. Materials and Methods. From February 2001 to February 2021, we have collected 152 randomized controlled trials of aPDT for peri-implantitis by searching the experimental studies and clinical trials published in PubMed, Embase, Web of Science, and Google Scholar databases via online search. After screening the retrieved literature, we finally selected 10 statistically significant literature for evaluation and review. Results. Compared with the traditional nonsurgical treatment of peri-implantitis, the aPDT was superior to the traditional mechanical irrigation treatment group in terms of periodontal indexes PD, BOP, PLI, and postoperative effect, and the difference was statistically significant ( P < 0.05 ). Furthermore, the combination of the aPDT and other treatments shows the synergistic antibacterial effect, signifying better clinical effect in many aspects ( P < 0.05 ). In these 10 papers, by comparing the probe depth (PD), bleeding on probing (BOP), synosteosis, and periodontal pathogenic bacteria detection, etc., obtained after treating peri-implantitis by application of the antimicrobial photodynamic therapy, and using the SPSS data analysis software for statistical data processing, we found that the antimicrobial photodynamic therapy combined with other periodontal treatments has a more prominent postoperative effect. Meanwhile, the antibacterial photodynamic therapy with targeted action of photosensitizer has strong specificity to some bacteria, while the synthetic photosensitize for antibacterial photodynamic therapy can show good inactivation effect on broad-spectrum periodontal anaerobes without side effect. Conclusion. The experimental studies and clinical data of antibacterial photodynamic therapy for treating peri-implantitis show a good postoperative treatment effect. In addition, it did not develop resistance due to the use of antibiotic drugs. Owing to multiple advantages from combining antibacterial photodynamic therapy and other treatments, it is applicable for clinical treatment.

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Warloe, Trond, and Sigrid I. Kvaal. "Photodynamic Treatment of Oral Lesions." Journal of Environmental Pathology, Toxicology and Oncology 26, no. 2 (2007): 127–33. http://dx.doi.org/10.1615/jenvironpatholtoxicoloncol.v26.i2.70.

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9

Gümüs, Pinar, and Nurcan Buduneli. "Photodynamic Therapy and Periodontal Treatment." Clinical Anti-Inflammatory & Anti-Allergy Drugs 2, no. 1 (May 17, 2016): 38–42. http://dx.doi.org/10.2174/221270380201160517190017.

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ÖZCAN, Erkan. "Periodontitis and Photodynamic Treatment: Review." Turkiye Klinikleri Journal of Dental Sciences 21, no. 3 (2015): 229–34. http://dx.doi.org/10.5336/dentalsci.2011-25591.

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Sohl, Sirius, Friederike Kauer, Uwe Paasch, and Jan C. Simon. "Photodynamic treatment of cutaneous leishmaniasis." JDDG 5, no. 2 (February 2007): 128–30. http://dx.doi.org/10.1111/j.1610-0387.2007.06177.x.

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Morris, Tanya. "PHOTODYNAMIC THERAPY TREATMENT IN CHOLANGIOCARCINOMA." Gastroenterology Nursing 32, no. 2 (March 2009): 146. http://dx.doi.org/10.1097/01.sga.0000349583.51321.ff.

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Mazur, Anna, Katarzyna Koziorowska, Klaudia Dynarowicz, David Aebisher, and Dorota Bartusik-Aebisher. "Photodynamic Therapy for Treatment of Disease in Children—A Review of the Literature." Children 9, no. 5 (May 10, 2022): 695. http://dx.doi.org/10.3390/children9050695.

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Photodynamic therapy is a mode of treatment whereby local irradiation of an administered photosensitizer with light of a specific wavelength generates cytotoxic reactive oxygen species. Despite the upward trend in the popularity of this method in adults, it is not yet commonly used in the treatment of children. Due to certain limitations, underdeveloped treatment regimens and potential side effects, the use of photodynamic therapy in the pediatric population is still in the initial phases of evaluation in clinical trials. Method: This study is a review of articles in English from the databases PubMed and Web of Science retrieved by applying the search term “photodynamic therapy in children” from 2000–2020. Results: Based on the literature review, we analyze selected pediatric clinical cases in which photodynamic therapy was used for treatment in children. Examples of photodynamic therapy for treatment of dermatological diseases, diseases of the mucosa of the upper respiratory tract, halitosis, eye diseases and brain tumors are described. The paper describes the effectiveness of anti-cancer photodynamic therapy, including its use in antibacterial therapy. Conclusions: The results of the analysis suggest the potential of photodynamic therapy for the treatment of various diseases in children.

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Glowacka-Sobotta, Arleta, Maciej Wrotynski, Michal Kryjewski, Lukasz Sobotta, and Jadwiga Mielcarek. "Porphyrinoids in photodynamic diagnosis and therapy of oral diseases." Journal of Porphyrins and Phthalocyanines 23, no. 01n02 (January 2019): 1–10. http://dx.doi.org/10.1142/s108842461850116x.

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Photodynamic methods have found application not only in the treatment process as photodynamic therapy but also for the early detection of neoplastic lesions and tumors as photodynamic diagnosis. Early detection of the disease allows not only to avoid the patient’s lifetime risk but also significantly reduce the costs of anticancer therapy, which are increasing every year. There is a constant search for new and more effective photosensitizers which will provide safety in therapy while maintaining efficiency. This paper summarizes recent reports focused on the photodynamic diagnosis of oral cancers. Moreover, it shows methods of the photodynamic treatment of oral verrucous hyperplasia, erythroleukoplakia, and oral leukoplakia. The treatment of choice for these diseases is a surgical excision, which always leads to scar formation. Photodynamic therapy provides a new scar-less tool for the treatment.

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Panaseykin, Y. A., V. N. Kapinus, E. V. Filonenko, V. V. Polkin, F. E. Sevrukov, P. A. Isaev, S. A. Ivanov, and A. D. Kaprin. "Photodynamic therapy treatment of oral cavity cancer in patients with comorbidities." Biomedical Photonics 11, no. 4 (January 31, 2023): 19–24. http://dx.doi.org/10.24931/2413-9432-2022-11-4-19-24.

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We report the experience of radical treatment by photodynamic therapy of patients with squamous cell carcinoma of oral cavity with serious side diseases. Completed treatment of two patients with serious side diseases (HIV infection with associated pulmonary hypertension of high degree and cardiac pathology) suffered from cancer of oral cavity. Extensive surgical treatment and/or aggressive course of chemoradiation therapy were not indicated to them due to concomitant pathology. Both patients were diagnosed with squamous cell carcinoma of oral cavity, with appropriate stage Ist. сT1N0M0. Patients received treatment by photodynamic therapy with chorine photosensitizer in dose 1 mg/kg. Options of photodynamic were: output power – 1.5W, power density – 0.31 W/cm2, light dose – 300 J/cm2. After one time session of photodynamic therapy, in both cases full response was diagnosed (according to RECIST 1.1). In one case the second session of photodynamic therapy was performed due to concomitant disease of oral cavity – multiply lesions of leukoplakia and after was diagnosed full remission of all lesions. Major adverse event was pain during the first 5-7 days after treatment, curable by painkillers. Follow-up (IQR) was 12 and 18 month respectively with no evidence of progression. It is available to avoid extensive surgical treatment and aggressive course of chemoradiation therapy (as an alternative) with the use of photodynamic therapy. Photodynamic therapy is minimally invasive method of radical treatment of localized squamous cell carcinoma of oral cavity with minimal adverse events, and could be especially relevant in patients with serious concomitant diseases.

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KAWASE, Yuki, Hiroshi ISEKI, Soko IKUTA, and Yoshihiro MURAGAKI. "Minimally Invasive Laser Treatment and Diagnosis : Photodynamic Therapy and Photodynamic Diagnosis." Journal of the Japan Society for Precision Engineering 81, no. 4 (2015): 298–302. http://dx.doi.org/10.2493/jjspe.81.298.

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Cordey, Helen, Ronan Valentine, Andrea Lesar, Harry Moseley, Ewan Eadie, and Sally Ibbotson. "Daylight photodynamic therapy in Scotland." Scottish Medical Journal 62, no. 2 (May 2017): 48–53. http://dx.doi.org/10.1177/0036933017695156.

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Chronic sun-induced dysplastic skin changes (actinic keratoses) are extremely common in fair-skinned people in Scotland. These changes are a major cause of morbidity and may develop into skin cancer. Actinic keratoses are often extensive and pose a therapeutic challenge as field-directed treatment is required for chronic disease management. One such treatment approach is hospital-based photodynamic therapy, which is a well-established treatment in Scotland for actinic keratoses, using a photosensitiser pro-drug and red LED light irradiation. However, photodynamic therapy using daylight as the activating light source is increasingly and effectively used in continental Europe, but had not been explored in Scotland until we initiated this in 2013. We report our experience of daylight photodynamic therapy in 64 patient-treatment courses and demonstrate that this can be an effective, well-tolerated treatment, which is liked by patients. Our most recent data show that most patients (73%) achieved clearance or at least a good response to treatment and had high levels of satisfaction with daylight photodynamic therapy. Daylight exposure measurements indicated that treatment is feasible in Scotland between April to September. Daylight photodynamic therapy is an important advancement in treatment options for Scottish patients with extensive pre-cancerous field changes and provides opportunities for home-based treatment and increased efficiency of photodynamic therapy services.

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Osuchowski, Michał, David Aebisher, Dorota Bartusik-Aebisher, Magdalena Krupka-Olek, Klaudia Dynarowicz, Maria Przygoda, and Aleksandra Kawczyk-Krupka. "Photodynamic Therapy-Adjunctive Therapy in the Treatment of Prostate Cancer." Diagnostics 12, no. 5 (April 28, 2022): 1113. http://dx.doi.org/10.3390/diagnostics12051113.

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The alarming increase in the number of advanced-stage prostate cancer cases with poor prognosis has led to a search for innovative methods of treatment. In response to the need for implementation of new and innovative methods of cancer tissue therapy, we studied photodynamic action in excised prostate tissue in vitro as a model for photodynamic therapy. To ascertain the effects of photodynamic action in prostate tissue, Rose Bengal (0.01 to 0.05 mM) was used as a photosensitizer in the presence of oxygen and light to generate singlet oxygen in tissues in vitro. Five preset concentrations of Rose Bengal were chosen and injected into prostate tissue samples (60 samples with 12 replications for each RB concentration) that were subsequently exposed to 532 nm light. The effects of irradiation of the Rose Bengal infused tissue samples were determined by histopathological analysis. Histopathological examination of prostate samples subjected to photodynamic action revealed numerous changes in the morphology of the neoplastic cells and the surrounding tissues. We conclude that the morphological changes observed in the prostate cancer tissues were a result of the photogeneration of cytotoxic singlet oxygen. The tissue damage observed post photodynamic action offers an incentive for continued in vitro investigations and future in vivo clinical trials.

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Prinsze, C., T. M. A. R. Dubbelman, and J. Van Steveninck. "Potentiation of thermal inactivation of glyceraldehyde-3-phosphate dehydrogenase by photodynamic treatment. A possible model for the synergistic interaction between photodynamic therapy and hyperthermia." Biochemical Journal 276, no. 2 (June 1, 1991): 357–62. http://dx.doi.org/10.1042/bj2760357.

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Thermal inactivation of glyceraldehyde-3-phosphate dehydrogenase appeared to be caused by a conformational mechanism, without involvement of covalent reactions. On the other hand, photodynamic inactivation of the enzyme (induced by illumination in the presence of Photofrin II) was caused by photo-oxidation of the essential thiol group in the active centre. A short photodynamic treatment of the enzyme, leading to only a limited inactivation, caused a pronounced potentiation of subsequent thermal inactivation, as measured over the temperature range 40-50 degrees C. Analysis of the experimental results according to the Arrhenius equation revealed that both the activation energy of thermal inactivation and the frequency factor (the proportionality constant) were significantly decreased by the preceding photodynamic treatment. The experimental results indicate a mechanism in which limited photodynamic treatment induced a conformational change of the protein molecule. This conformational change did not contribute to photodynamic enzyme inhibition, but was responsible for the decreased frequency factor and activation energy of subsequent thermal inactivation of the enzyme. The opposing effects of decreased activation energy and decreased frequency factor resulted in potentiation of thermal inactivation of the enzyme over the temperature range 40-50 degrees C. With other proteins, different results were obtained. With amylase the combined photodynamic and thermal effects were not synergistic, but additive, and photodynamic treatment had no effect on the frequency factor and the activation energy of thermal inactivation. With respect to myoglobin denaturation, the photodynamic and thermal effects were antagonistic over the whole practically applicable temperature range. Limited photodynamic treatment protected the protein against heat-induced precipitation, concomitantly increasing both the frequency factor and the activation energy of the process. These results offer a model for one of the possible mechanisms of synergistic interaction between photodynamic therapy and hyperthermia in cancer treatment.

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Yoneda, Ai, Harumi Wakiyama, Junko Kurihara, and Takashi Kitaoka. "Initial treatment for polypoidal choroidal vasculopathy: Ranibizumab combined with photodynamic therapy or fixed-dosing aflibercept monotherapy." European Journal of Ophthalmology 30, no. 6 (September 2, 2019): 1473–79. http://dx.doi.org/10.1177/1120672119871886.

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Purpose: To compare the 2-year outcomes of combination therapy using intravitreal ranibizumab and photodynamic therapy with those of fixed-dosing intravitreal aflibercept monotherapy as initial treatment for treatment-naïve polypoidal choroidal vasculopathy. Methods: We retrospectively reviewed 63 eyes of 61 patients with treatment-naïve polypoidal choroidal vasculopathy who had undergone at least 24 months of follow-up. In total, 43 eyes underwent intravitreal ranibizumab–photodynamic therapy combination therapy and 20 eyes underwent fixed-dosing intravitreal aflibercept monotherapy. Visual outcomes and the number of treatments were compared between the two groups. Results: The mean logarithm of minimal angle of resolution best-corrected visual acuity significantly improved from 0.48 ± 0.41 at baseline to 0.30 ± 0.47 at 24 months in the intravitreal ranibizumab–photodynamic therapy group ( p = .0002) and from 0.30 ± 0.18 at baseline to 0.16 ± 0.18 at 24 months in the intravitreal aflibercept group ( p = .004), with no significant intergroup differences. The mean number of intravitreal ranibizumab or intravitreal aflibercept injections over 24 months was 5.7 ± 4.5 in the intravitreal ranibizumab–photodynamic therapy group and 12.2 ± 3.8 in the intravitreal aflibercept group ( p < .0001). Conclusion: The intravitreal ranibizumab–photodynamic therapy combination therapy was noninferior to fixed-dosing intravitreal aflibercept monotherapy in improving visual acuity and required fewer injections.

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Samusenkov, V. O., V. N. Tsarev, and M. S. Podporin. "Comparative evaluation of the effectiveness of light activation of photosensitizers in photodynamic therapy of periodontitis using different wavelengths." Stomatology for All / International Dental review, no. 2019 3 (88) (September 2019): 4–9. http://dx.doi.org/10.35556/idr-2019-3(88)4-9.

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Dentists are always in quest of new methods for the treatment of periodontal diseases, and photodynamic therapy (PDT) is considered one of the most effective methods. A significant improvement in the clinical pic-ture was obtained in all patients throughout the control period of observation of the patients as a result of the treatment with the use of PDT. According to the data from research study it can be said that photodynamic therapy is an effective and gentle method of antibacterial treatment of inflammatory periodontal diseases, which can be effectively used to prevent exacerbations of chronic inflammatory periodontal diseases, to achieve a long-term positive effect and to refuse, in some cases, from surgical methods of treatment. There is a signifi-cant increase in the duration of remission of the disease, improvement of microcirculatory blood circulation in per-iodontal tissues and a small microbial contamination of periodontal pockets of patients treated with photodynam-ic therapy in the long term compared with groups of pa-tients treated with only antiseptic and antibacterial drugs.

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Tseimakh, A. Е., S. G. Shtofin, V. А. Kurtukov, V. N. Teplukhin, Ia N. Shoykhet, and M. E. Tseimakh. "Prediction of the effect of the photodynamic therapy on survival in patients with stage IV of pancreatic cancer." Biomedical Photonics 11, no. 4 (January 31, 2023): 25–31. http://dx.doi.org/10.24931/2413-9432-2022-11-4-25-31.

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The article presents the results of a study of survival after complex palliative treatment of patients with malignant tumors of the pancreas stage IV in two comparable groups of patients. The aim of the study is to determine the prognostic factors affecting survival in patients with stage IV pancreatic cancer who received local and systemic photodynamic therapy. In the main group, which consisted of 19 patients with histologically veried stage IV pancreatic maligant tumor, palliative treatment was performed using photodynamic therapy. In the comparison group, consisting of 28 patients with histologically veried malignant tumor of the pancreas stage IV, palliative treatment was performed without the use of photodynamic therapy. On the background of the use of local and systemic photodynamic therapy in the main group it was observed a statistically significant increase in life expectancy compared with the comparison group. The three-month survival of patients who received local and systemic photodynamic therapy is affected by the level of brinogen before treatment. The level of brinogen above 3.4 g/l makes it possible to predict a decrease in the probability of three-month survival after photodynamic therapy. Thus, complex treatment with the use of photodynamic therapy for stage IV malignant tumors of the pancreas can increase the survival rate of patients.

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Zheng‡, Rongrong, Xiayun Chen‡, Linping Zhao, Ni Yang, Runtian Guan, Ali Chen, Xiyong Yu, Hong Cheng, Chang Wang, and Shiying Li. "A porphysome-based photodynamic O2 economizer for hypoxic tumor treatment by inhibiting mitochondrial respiration." Chemical Communications 57, no. 34 (2021): 4134–37. http://dx.doi.org/10.1039/d1cc00544h.

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V, Dunaevskaya, and Tzerkovsky DA. "Photodynamic Therapy in Vulvar Dystrophy Treatment." Archives of Clinical and Biomedical Research 02, no. 02 (2018): 42–51. http://dx.doi.org/10.26502/acbr.5017040.

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HAYASHI, Junichi, Takashi SAITO, Akira KANEDA, and Katsuo AIZAWA. "Photodynamic Diagnosis and Treatment of Atheroma." JOURNAL OF JAPAN SOCIETY FOR LASER SURGERY AND MEDICINE 18, no. 4 (1997): 61–65. http://dx.doi.org/10.2530/jslsm1980.18.4_61.

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Hayashi, Junichi, Takashi Saito, and Katsuo Aizawa. "Photodynamic Diagnosis and Treatment for Atherosclerosis." Review of Laser Engineering 27, Supplement (1999): 173. http://dx.doi.org/10.2184/lsj.27.supplement_173.

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Nseyo, U. O., T. J. Dougherty, D. Boyle, W. Potter, L. S. Englander, R. P. Huben, and J. E. Pontes. "Experimental Photodynamic Treatment of Canine Bladder." Journal of Urology 133, no. 2 (February 1985): 311–15. http://dx.doi.org/10.1016/s0022-5347(17)48929-4.

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David, Olivier, Ludovic Bourré, Youcef Krika, Moïse Durand, and Thierry Patrice. "DNA damages after SIM01 photodynamic treatment." Photodiagnosis and Photodynamic Therapy 2, no. 1 (March 2005): 25–33. http://dx.doi.org/10.1016/s1572-1000(05)00011-6.

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Sadykov, R. R., and K. R. Kasimova. "60 Hemangioma treatment with photodynamic therapy." Photodiagnosis and Photodynamic Therapy 9 (August 2012): S20—S21. http://dx.doi.org/10.1016/s1572-1000(12)70061-3.

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Kvaal, Sigrid I., Even Angell-Petersen, and Trond Warloe. "Photodynamic treatment of oral lichen planus." Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 115, no. 1 (January 2013): 62–70. http://dx.doi.org/10.1016/j.oooo.2012.08.448.

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Agha-hosseini, Farzaneh, and Nada Mohammad Pour. "Photodynamic treatment of oral lichen planus." Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 117, no. 2 (February 2014): 257. http://dx.doi.org/10.1016/j.oooo.2013.03.022.

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LIANG, YI, LI-MING LU, YONG CHEN, and YOU-KUN LIN. "Photodynamic therapy as an antifungal treatment." Experimental and Therapeutic Medicine 12, no. 1 (May 11, 2016): 23–27. http://dx.doi.org/10.3892/etm.2016.3336.

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Samusenkov, V. O., V. N. Tsarev, E. V. Ippolitov, A. V. Yumashev, and I. A. Yudin. "Photodynamic therapy in the treatment of periodontal diseases." Stomatology for All / International Dental review, no. 2020 4 (93) (December 2020): 12–14. http://dx.doi.org/10.35556/idr-2020-4(93)12-14.

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The article presents an overview of the use of photodynamic therapy in modern dentistry based on the literature sources. Various types of photosensitizers are presented, the action of which has a good effect on the course of the process in periodontal pockets. The conclusion is made about the vantages of using this method in the treatment of inflammatory periodontal diseases, as well as the effect of photodynamic therapy on the periodontal microbiota, which has a positive effect on the treatment of patients.

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Malina, Lukáš, Kateřina Bartoň Tománková, Barbora Hošíková, Jana Jiravová, Jakub Hošík, Jana Zapletalová, and Hana Kolářová. "XANTHENE DYES-MEDIATED IN VITRO PHOTODYNAMIC TREATMENT OF CANCER AND NON-CANCER CELL LINES." Lékař a technika - Clinician and Technology 50, no. 3 (March 19, 2021): 114–21. http://dx.doi.org/10.14311/ctj.2020.3.05.

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Rose bengal and erythrosin B are xanthene dyes mainly known and used as antimicrobial agents, but due to their photodynamic activity they are also potential photosensitizers for cancer photodynamic therapy. The aim of this work is to study a photodynamic efficacy of rose bengal and erythrosin B against human skin melanoma and mouse fibroblast cell lines, compare them with each other and find out their photodynamic properties induced by light emitting diodes with total light dose of 5 J/cm2. To fully identify and understand photodynamic properties of both potentially effective photosensitizers, a set of complex in vitro tests such as cell cytotoxic assay, measurement of reactive oxygen species production, mitochondrial membrane potential change assay, mode of cell death determination or comet assay were made. Although both photosensitizers proved to have similar properties such as increasing production of reactive oxygen species with the higher concentration, predominance of necrotic mode of death or genotoxicity, the more effective photosensitizer was rose bengal because its EC50 was over 20 times lower for both cell lines than in case of erythrosin B.

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Astuti, S. D., N. D. Drantantiyas, A. P. Putra, P. S. Puspita, A. Syahrom, and S. Suhariningsih. "Photodynamic effectiveness of laser diode combined with ozone to reduce STaphylicoccus aureus biofilm with exogenous chlorophyll of Dracaena angustifolia leaves." Biomedical Photonics 8, no. 2 (July 10, 2019): 4–13. http://dx.doi.org/10.24931/2413-9432-2019-8-2-4-13.

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Photodynamic inactivation is an effective treatment that uses light irradiation, photosensitizer and oxygen. The aim of this study was to determine photodynamic effectiveness of laser diode combined with ozone to reduce Staphylococcus aureus biofilm using exogenous chlorophyll (Chlo). The chlorophyll was extracted from leave of Dracaena angustifolia. To determine the antibacterial effect of S. aureus biofilm treatments, samples were separated into Chlo, Laser, Chlo+Laser, Ozone, Ozone+Laser, Chlo+Ozone+Laser categories. The data were analyzed using ANOVA test. The result of this study showed that Chlo+Ozone+Laser combine treatment at 20 s exposure of ozone with 4 min of irradiation time lead to 80.26 % reduction of biofilm activity, which was the highest efficacy of all the treatment groups. The combination of laser, chlorophyll and lower ozone concentration increases the effectiveness of photodynamic inactivation.

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Shivanna, Vasundhara, and Rucha Nilegaonkar. "Photodynamics in Dentistry - A Review." CODS Journal of Dentistry 7, no. 1 (2015): 13–18. http://dx.doi.org/10.5005/cods-7-1-13.

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Abstract To overcome limitations of antibiotics like microbial resistance, systemic side effects and limitation of spectrum of microorganisms affected, an effective and alternative therapy needs to replace the conventional treatment. Photodynamic therapy (PDT) consists of a photoactive dye (photosensitizer) that is activated by specific wavelength light in the presence of oxygen. PDT has shown potential in the treatment of oral leukoplakia, oral lichen planus, and head and neck cancer, treatment of bacterial, fungal, parasitic, and viral infections. The absence of mutagenic effects of PDT is an important factor for safety during treatment. How to cite this article Shivanna V, Nilegaonkar R. Photodynamics in Dentistry – A Review. CODS J Dent 2015;7:13-18

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Romeo, Umberto, Gianna Maria Nardi, Fabrizio Libotte, Silvia Sabatini, Gaspare Palaia, and Felice Roberto Grassi. "The Antimicrobial Photodynamic Therapy in the Treatment of Peri-Implantitis." International Journal of Dentistry 2016 (2016): 1–5. http://dx.doi.org/10.1155/2016/7692387.

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Introduction. The aim of this study is to demonstrate the effectiveness of addition of the antimicrobial photodynamic therapy to the conventional approach in the treatment of peri-implantitis.Materials and Methods. Forty patients were randomly assigned to test or control groups. Patients were assessed at baseline and at six (T1), twelve (T2), and twenty-four (T3) weeks recording plaque index (PlI), probing pocket depth (PPD), and bleeding on probing (BOP); control group received conventional periodontal therapy, while test group received photodynamic therapy in addition to it.Result. Test group showed a 70% reduction in the plaque index values and a 60% reduction in PD values compared to the baseline. BOP and suppuration were not detectable. Control group showed a significative reduction in plaque index and PD.Discussion. Laser therapy has some advantages in comparison to traditional therapy, with faster and greater healing of the wound.Conclusion. Test group showed after 24 weeks a better value in terms of PPD, BOP, and PlI, with an average pocket depth value of 2 mm, if compared with control group (3 mm). Our results suggest that antimicrobial photodynamic therapy with diode laser and phenothiazine chloride represents a reliable adjunctive treatment to conventional therapy. Photodynamic therapy should, however, be considered a coadjuvant in the treatment of peri-implantitis associated with mechanical (scaling) and surgical (grafts) treatments.

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Dailton Guedes de Oliveira Moraes, Carlos, Bruno Henrique Godoi, Isabel Chaves Silva Carvalho, Jessica Cristina Pinto, Rafaella Carvalho Rossato, Newton Soares da Silva, and Cristina Pacheco Soares. "Genotoxic effects of photodynamic therapy in laryngeal cancer cells – An in vitro study." Experimental Biology and Medicine 244, no. 3 (January 23, 2019): 262–71. http://dx.doi.org/10.1177/1535370219826544.

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Photodynamic therapy provides the formation of reactive oxygen species that are capable of inducing cell death. Human laryngeal carcinoma (HEp-2) cells have been evaluated in this study under PDT treatment. Cells were treated with photosensitizer aluminum phthalocyanine tetrasulfonate (AlPcS4) and irradiated with a Biopdi/Irrad-Led5 660 LED with 660 nm wavelength, intensity of delivered light of 25 mW/cm2, power of 70 mW, fluence of 5 J/cm2 for 24 h and 48 h, and then evaluated. Cell population was not increased by PDT treatment after the tested period. The apoptosis assay demonstrated that control groups exhibit approximately 60% of living cells in the 24 h and 48 h periods, however. A significant increase in apoptotic cells was observed after the photodynamic therapy treatments, for both 24 and 48 h groups. Over 50% of cells were under apoptosis after photodynamic therapy, evidencing a death process generated from the oxidative damage of the treatment. Comet assay and micronucleus assessments, both of which evaluate genotoxicity, demonstrated favorable results to damages caused by the photodynamic therapy treatment. Thus, photodynamic therapy is proposed to damage nuclear cells and the subcellular structure of carcinogenic cells. Impact statement Recently, the use of photodynamic therapy grows as an alternative treatment for cancer, since it has a noninvasive characteristic and affinity to the tumor tissue. Accordingly, understanding the therapy’s foci of action is important for the technique improvement. This work aims to understand the genotoxic effect triggered by the therapy action, thus evidencing the permanent changes caused to the genetic material of the tumor cell after the treatment. Therefore, to increase the knowledge in this study field, the methodology of the comet assay and count of micronucleus formed after the therapy was adopted in order to understand if the damage caused to the DNA of tumor cell makes its replication process unfeasible in future generations. The study allows a better therapeutic approach to the cancer treatment, making the process of association between therapies a more effective option during the disease treatment.

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Gossner, L. "Photodynamic Therapy: Esophagus." Canadian Journal of Gastroenterology 16, no. 9 (2002): 642–44. http://dx.doi.org/10.1155/2002/918694.

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Photodynamic therapy (PDT) is a minimally invasive, organ-preserving therapeutic modality, involving three separate components - light, oxygen and a photosensitizing drug. The principles of PDT are described, and the indications for its use are reviewed. Although a widespread clinical application for PDT has not yet emerged, PDT may establish itself as an endoscopic procedure with few or no side effects in the treatment of Barrett’s esophagus (high-grade dysplasia and early carcinoma) and, in selected cases, for the treatment of early squamous cell carcinoma.

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Kubanov, A. A., I. N. Kondrakhina, and N. V. Gribanov. "Photodynamic therapy with methyl aminolevulinate in the treatment of basal cell carcinoma." Vestnik dermatologii i venerologii 91, no. 1 (February 24, 2015): 32–40. http://dx.doi.org/10.25208/0042-4609-2015-91-1-32-40.

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The article presents the results of the studies on the effectiveness of treatment basal cell carcinoma of the skin with photodynamic therapy with 5-aminolevulinic acid and methyl aminolevulinate. The results of the comparing trials between photodynamic therapy with methyl aminolevulinate and different other treatment modalities are presented.

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Prinsze, C., K. Tijssen, T. M. A. R. Dubbelman, and J. Van Steveninck. "Potentiation of hyperthermia-induced haemolysis of human erythrocytes by photodynamic treatment. Evidence for the involvement of the anion transporter in this synergistic interaction." Biochemical Journal 277, no. 1 (July 1, 1991): 183–88. http://dx.doi.org/10.1042/bj2770183.

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Heat treatment of human erythrocytes led to increased passive cation permeability, followed by haemolysis. K+ leakage was linear up to a loss of about 80% in the temperature range 46-54 degrees C. Kinetic analysis of the results revealed an activation energy of 246 kJ/mol, implicating a transition in the membrane as critical step. Pretreatment of erythrocytes with 4,4′-di-isothiocyano-2,2′-stilbenedisulphonate, chymotrypsin or chlorpromazine caused a potentiation of subsequent heat-induced K+ leakage. Photodynamic treatment of erythrocytes with Photofrin II, eosin isothiocyanate or a porphyrin-Cu2+ complex as sensitizer also induced an increase in passive cation permeability, ultimately resulting in colloid osmotic haemolysis. The combination of photodynamic treatment immediately followed by hyperthermia had a synergistic effect on K+ leakage. Analysis of the results by the Arrhenius equation revealed that both the activation energy and the frequency factor of heat-induced K+ leakage were decreased significantly by preceding photodynamic treatment, suggesting that hyperthermia and photodynamic treatment have a common target for the induction of K+ leakage. Several lines of reasoning indicate that this common target is band 3. A model is thus proposed for the observed potentiation of hyperthermically induced K+ leakage by photodynamic treatment, in which photo-oxidation of band 3 results in increased sensitivity to subsequent thermal denaturation. These phenomena may be of more general significance, as photodynamic treatment and hyperthermia interacted synergistically with respect to K+ leakage with L929 fibroblasts also.

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Genske, Rodrigo Daniel, Eduardo Alexandre Loth, Vanessa Cecatto, Rinaldo Ferreira Gandra, Cleverson Marcelo Pilatti, and Maricília Silva Costa. "Terapia fotodinâmica na artrite experimental induzida por Paracoccidioides brasiliensis." Scientia Medica 29, no. 2 (August 22, 2019): 32705. http://dx.doi.org/10.15448/1980-6108.2019.2.32705.

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AIMS: To evaluate the effectiveness of photodynamic therapy with Brilliant Blue G in the treatment of an experimental model of arthritis by Paracoccidioides brasiliensis (P. brasiliensis). METHODS: After the induction of experimental arthritis with isolated from P. brasiliensis of lineage Pb18 in the knees of Wistar rats, the animals were divided into groups and submitted to photodynamic therapy with intra-articular Brilliant Blue G photosensitizer and laser therapy only, without Brilliant Blue G. All groups received their respective treatments from the seventh to the 11th day. For edema analysis, the knee lateral-lateral diameter of each animal was measured daily and after the treatment period the animals were sacrificed for experimental knee dissection and blood collection for analysis by ELISA, in order to quantify levels of anti-P. brasiliensis antibodies. RESULTS: The results showed that the application of photodynamic therapy was able to prevent the formation of edema when compared to the control (p>0.005), as well as the production of anti-Gp-43 antibodies from P. brasiliensis (p=0.001). In the anatomopathological examination it was possible to observe a higher degree of synovitis and a greater presence of granulomas with the fungus inside the group that did not receive treatment when compared to the groups that received the photodynamic therapy. CONCLUSIONS: Photodynamic therapy was effective in attenuating the experimental arthritis induced by P. brasiliensis in the proposed joint model.

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Weiss, Alan A., Holly AR Wiesinger, and David Owen. "Photodynamic Therapy in Barrett’s Esophagus: Results of Treatment of 17 Patients." Canadian Journal of Gastroenterology 20, no. 4 (2006): 261–64. http://dx.doi.org/10.1155/2006/954153.

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BACKGROUND: Barrett’s esophagus (BE) with dysplasia may progress to esophageal adenocarcinoma. Photodynamic therapy is a promising treatment for BE.OBJECTIVE: To determine if photodynamic therapy is an acceptable alternative to esophagectomy in BE patients with high-grade dysplasia or early adenocarcinoma.METHODS: Seventeen patients were treated with photodynamic therapy for BE and high-grade dysplasia or early esophageal adenocarcinoma. Patients with residual Barrett’s epithelium were treated with supplemental argon plasma coagulation or potassium titanyl phosphate laser. Patients underwent follow-up endoscopy three, six, nine and 12 months post-treatment, then every six to 12 months. Mean follow-up was 21 months.RESULTS: High-grade dysplasia or early adenocarcinoma was completely eliminated in nine of 15 (60%) patients. High-grade dysplasia was downgraded in one patient, persisted in one patient and progressed in four patients. Two patients with early esophageal adenocarcinoma were nonresponders. Complications included stricture, sunburn, urticaria, small pleural effusions, esophageal spasm and transient atrial fibrillation.CONCLUSIONS: Photodynamic therapy with supplemental ablation is a good, noninvasive therapy for elimination of high-grade dysplasia and early adenocarcinoma in BE. Failure to eliminate dysplastic epithelium occurred in 40% of the patients, thereby necessitating careful follow-up.

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Zavadskaya, T. S. "PHOTODYNAMIC THERAPY IN THE TREATMENT OF GLIOMA." Experimental Oncology 37, no. 4 (December 22, 2015): 234–41. http://dx.doi.org/10.31768/2312-8852.2015.37(4):234-241.

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The review presents the data on the use of photodynamic therapy (PDT) for the treatment of patients with malignant brain tumors. One and two-year survival rate and an increase in overall median survival of PDT-treated patients compared with standard treatment indicate a promising prospects for PDT in neurooncology.

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Kasymov, Bahtijar G., Nasrulla A. Shanazarov, Timur M. Muratov, Gulnur D. Daniyarova, Akylbek M. Zhumakayev, Pavel S. Kyzlasov, Anastasia A. Kazhera, Margarita N. Slesarevskaya, Igor V. Kuzmin, and Salman Kh Al-Shukri. "Photodynamic methods of treatment of nonmuscular-invasive bladder cancer." Urology reports (St. - Petersburg) 11, no. 4 (December 15, 2021): 355–63. http://dx.doi.org/10.17816/uroved90554.

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The review article is devoted to the application of photodynamic therapy for non-muscle invasive bladder cancer. The data on the mechanism and pathogenetic bases of the application of this method of treatment, the method of its implementation, the advantages and disadvantages of the photosensitizers and the results of clinical studies are presented. It has been shown that intraoperative photodynamic therapy significantly reduces the rate of recurrence of bladder cancer after transurethral resection, including in patients with carcinoma in situ and multifocal growth of urothelial tumors.

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Lonsdorf, Anke S., Aric Keller, Julia Hartmann, Alexander H. Enk, and Patrick Gholam. "Ablative Fractional Laser-assisted Low-irradiance Photodynamic Therapy for Treatment of Actinic Keratoses in Organ Transplant Recipients: A Prospective, Randomized, Intraindividual Controlled Trial." Acta Dermato-Venereologica 102 (April 13, 2022): adv00694. http://dx.doi.org/10.2340/actadv.v102.1057.

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Pain and inferior efficacy are major limiting factors of conventional photodynamic therapy for the field treatment of actinic keratoses in immunosuppressed organ transplant recipients. This prospective randomized controlled study evaluates the efficacy and tolerability of ablative fractional laser system pretreatment combined with low-irradiance photodynamic therapy (18.5 mW/cm2) compared with conventional photodynamic therapy (61.67 mW/cm2) in the treatment of actinic keratoses on the face and scalp in organ transplant recipients, using a red light-emitting diode lamp at a total light dose of 37 J/cm2. Low-irradiance photodynamic therapy combined with Er:YAG pretreatment achieved a significantly superior lesion response rate (mean ± standard deviation 77.3 ± 23.6%) compared with conventional photodynamic therapy (61.8 ± 21.4%; p = 0.025) in intra-individual fields at 3 months without negatively impacting pain (p = 0.777) or cosmetic outcome (p = 0.157).

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Mazur, Anna, Katarzyna Koziorowska, Klaudia Dynarowicz, David Aebisher, and Dorota Bartusik-Aebisher. "Vitamin D and Vitamin D3 Supplementation during Photodynamic Therapy: A Review." Nutrients 14, no. 18 (September 15, 2022): 3805. http://dx.doi.org/10.3390/nu14183805.

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Photodynamic therapy is an unconventional yet increasingly common method of treating dermatological diseases and cancer that is implemented more often in adults than in children. Current clinical uses include treatment of actinic keratosis, superficial basal cell carcinomas, and acne. Despite its high efficiency, photodynamic therapy support supplements have recently been reported in the literature, including calcitriol (1,25-dihydroxycholecalciferol), the active form of vitamin D, and vitamin D3 cholecalciferol. In clinical trials, photodynamic therapy enhanced with vitamin D or D3 supplementation has been reported for treatment of squamous cell skin cancers, actinic keratosis, and psoriasis. Experimental research on the effect of photodynamic therapy with vitamin D or D3 has also been carried out in breast cancer cell lines and in animal models. The aim of this review is to evaluate the usefulness and effectiveness of vitamin D and D3 as supports for photodynamic therapy. For this purpose, the Pubmed and Scopus literature databases were searched. The search keyword was: “vitamin D in photodynamic therapy”. In the analyzed articles (1979–2022), the authors found experimental evidence of a positive effect of vitamin D and D3 when used in conjunction with photodynamic therapy. An average of 6–30% (in one case, up to 10 times) increased response to photodynamic therapy was reported in combination with vitamin D and D3 as compared to photodynamic therapy alone. Implementing vitamin D and D3 as a supplement to photodynamic therapy is promising and may lead to further clinical trials and new clinical methodologies.

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Filonenko, Elena, Andrey Kaprin, Boris Alekseev, and Antonina Urlova. "Own Experience in Treatment of Patients with Penile Cancer Using Photodynamic Therapy." BioMed Research International 2015 (2015): 1–4. http://dx.doi.org/10.1155/2015/245080.

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Penile cancer is a rare pathology. For penile cancer surgical treatment, radiotherapy, chemotherapy, and combined modality treatment are available. Because of great importance of this organ for mental condition of patient, the development of organ-preserving methods allowing to minimize impact on patient’s quality of life without compromising of oncological results is desirable. In the Center of Laser and Photodynamic diagnosis and treatment of tumors in P.A. Herzen Moscow Cancer Research Institute the methods of photodynamic therapy in patients with penile cancer have been developed. From 2011 to 2013 the treatment was conducted in 11 patients with precancer and cancer of penile. The average age was 56.6. According to morphological diagnosis photodynamic therapy (PDT) was performed using two methods. One method included topical application of agent for PDT and the second intravenous administration of photosensitizer. For topical application alasens was used and for intravenous injection we applied radachlorine. All patients had no complications. Complete regression was achieved in 9 patients, and partial regression in 2. Thus, the results showed that photodynamic therapy for penile cancer stage Tis-1N0M0 permits performing organ-preserving treatment with satisfactory oncological results and no impairment of patient’s quality of life.

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Potapchuk, Anatoliy M., Vasyl M. Almashi, Igor Ya Lomnitsky, Vitaliy V. Rusyn, and Viktoria Hegedush. "THE USE OF PHOTODYNAMIC THERAPY IN THE TREATMENT OF DENTAL CARIES IN CHILDREN OF CONTAMINATED AREAS OF THE ECOSYSTEM OF THE UPPER TYSA REGION." Wiadomości Lekarskie 73, no. 3 (2020): 483–88. http://dx.doi.org/10.36740/wlek202003114.

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The aim: improving the effectiveness of treatment of dental caries in children using the method of photodynamic therapy. Materials and methods: The treatment of permanent tooth decay was performed in 35 children of the Upper Tysa region aged 12-15 years. Using the polymerase chain reaction method, the clinical efficacy of photodynamic therapy in the treatment of dentin caries was determined. Results: During the study, by PCR analysis, dentin caries most commonly revealed genetic markers of DNA of the five most virulent anaerobic bacteria: Prevotella intermedia, Fusobacterium spp., Enterococcus Faecalis, Veilonella spp., Candida albicans. After treatment of the carious cavity by the method of photodynamic therapy with exposure of 30 s – fusobacterium spp. were not detected, the detection rate of prevotella intermedia decreased 3-fold, enterococcus faecalis 3.5-fold, veilonella spp.- 5-fold, and candida albicans- 8-fold; after treatment with carious cavities with 60 s exposure – anaerobic microorganisms were not detected in the investigated samples. The effect of photodynamic therapy with laser exposure of 60 seconds on caries-causing streptococci resulted in their total death, and with exposure of 30 seconds – the frequency of isolated strains decreased several folds. Conclusions: The use of photodynamic therapy in the treatment of dentine caries is a highly effective and pathogenetically sound method of treatment that provides a significant reduction in the optional and obligate types of cariesogenic microorganisms.

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Naidoo, Channay, Cherie Ann Kruger, and Heidi Abrahamse. "Simultaneous Photodiagnosis and Photodynamic Treatment of Metastatic Melanoma." Molecules 24, no. 17 (August 29, 2019): 3153. http://dx.doi.org/10.3390/molecules24173153.

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Metastatic melanoma (MM) has a poor prognosis and is attributed to late diagnoses only when metastases has already occurred. Thus, early diagnosis is crucial to improve its overall treatment efficacy. The standard diagnostic tools for MM are incisional biopsies and/or fine needle aspiration biopsies, while standard treatments involve surgery, chemotherapy, or irradiation therapy. The combination of photodynamic diagnosis (PDD) and therapy (PDT) utilizes a photosensitizer (PS) that, when excited by light of a low wavelength, can be used for fluorescent non-destructive diagnosis. However, when the same PS is activated at a higher wavelength of light, it can be cytotoxic and induce tumor destruction. This paper focuses on PS drugs that have been used for PDD as well as PDT treatment of MM. Furthermore, it emphasizes the need for continued investigation into enhanced PS delivery via active biomarkers and passive nanoparticle systems. This should improve PS drug absorption in MM cells and increase effectiveness of combinative photodynamic methods for the enhanced diagnosis and treatment of MM can become a reality.

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