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Journal articles on the topic 'Photolon'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Shyla, R. S. "THE INTRODUCTION OF THE PHOTOSENSITIZER “FOTOLON” INTO THE COMMON BILE DUCT: INFLUENCE ON EXPERIMENTAL ANIMALS." Hepatology and Gastroenterology 4, no. 2 (2020): 189–95. http://dx.doi.org/10.25298/2616-5546-2020-4-2-189-195.

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Background. Photodynamic therapy of liver diseases involves the introduction of photosensitizers into the common bile duct. Objective – to evaluate the effect on animals of under pressure introduction of the photosensitizer “Photolon” into the common bile duct. Material and methods. The control group was injected with physiological solution under pressure, the experimental one – with “Photolon”. The vital signs of the animals, the laboratory data were studied, a histological examination of the liver and duct was carried out. Results. The blood parameters of the experimental animals and their p

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Kałas, Wojciech, Edyta Wysokińska, Magdalena Przybyło, et al. "Photoactive Liposomal Formulation of PVP-Conjugated Chlorin e6 for Photodynamic Reduction of Atherosclerotic Plaque." International Journal of Molecular Sciences 20, no. 16 (2019): 3852. http://dx.doi.org/10.3390/ijms20163852.

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Background: Liposomes serve as delivery systems for biologically active compounds. Existing technologies inefficiently encapsulate large hydrophilic macromolecules, such as PVP-conjugated chlorin e6 (Photolon). This photoactive drug has been widely tested for therapeutic applications, including photodynamic reduction of atherosclerotic plaque. Methods: A novel formulation of Photolon was produced using “gel hydration technology”. Its pharmacokinetics was tested in Sus scrofa f. domestica. Its cellular uptake, cytotoxicity, and ability to induce a phototoxic reaction were demonstrated in J774A.

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Istomin, Yu P., T. P. Artemyeva, and D. A. Tzerkovsky. "MULTIPLE-COURSE PHOTODYNAMIC THERAPY FOR VERRUCOUS LEUKOPLAKIA OF MUCOUS MEMBRANE OF BODY OF THE TONGUE (CASE REPORT)." Biomedical Photonics 5, no. 3 (2016): 41–42. http://dx.doi.org/10.24931/2413-9432-2016-5-3-41-42.

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The results of treatment of the patient with verrucous luekoplakia of mucous membrane of body of the tongue with photodynamic therapy are represented. In 2015 the patient underwent 4 courses of photodynamic therapy with photosensitizer photolon. Photolon was injected at dose of 2 mg/kg 3 h before irradiation (laser output power was 0.262 W, light dose – 50 and 100 J/cm2). The result of treatment was assessed as complete regression: 4 months after multiple-course photodynamic therapy there were no clinical and histological signs of luekoplakia.

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Tzerkovsky, D. A., and N. D. Adamenko. "Doxorubicin enhanced the antitumor efficacy of sonodynamic therapy with photosensitizer photolon in an in vivo experiment." Biomedical Photonics 13, no. 4 (2024): 22–32. https://doi.org/10.24931/2413-9432-2024-13-4-22-32.

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The antitumor effectiveness of sonodynamic therapy (SDT) with a chemotherapeutic drug and a photosensitizer (PS) of the chlorine series was studied in an in vivo experiment. The work was performed on 60 white nonlinear rats, divided into 2 series of 30 individuals each. Pliss lymphosarcoma, transplanted subcutaneously, was used as a tumor strain. Photolon was administered intravenously in a single dose of 2.5 mg/kg 2.5-3 hours before ultrasound exposure, and doxorubicin was administered intraperitoneally in a single dose of 5 mg/kg 0.5 hours before ultrasound exposure performed using the «Phya

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Mirkhalikov, F. R., A. F. Yusupov, and K. S. Ashirmatova. "Laser photodynamic therapy in the treatment of chronic central serous chorioretinopathy without choroidal neovascularization." Modern technologies in ophtalmology, no. 1 (March 25, 2022): 217–21. http://dx.doi.org/10.25276/2312-4911-2022-1-217-221.

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Purpose. To estimate preliminary results of photodynamic therapy in patients with chronic central serous chorioretinopathy (CSCRP) without choroidal neovascularization. Relevance. Central serous chorioretinopathy, especially the chronic form, remains an urgent problem in ophthalmology. To date, various methods of treating this pathology have been proposed, the main of which are conservative therapy and laser treatment. The latter includes Transpupillary Thermotherapy (TTT), Micropulse Laser Treatment and Photodynamic Therapy (PDT). Unfortunately, not one technique today can claim the title of

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Mirkhalikov, F. R., A. F. Yusupov, and K. S. Ashirmatova. "Laser photodynamic therapy in the treatment of chronic central serous chorioretinopathy without choroidal neovascularization." Modern technologies in ophtalmology, no. 1 (March 25, 2022): 217–21. http://dx.doi.org/10.25276/2312-4911-2022-1-217-221.

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Purpose. To estimate preliminary results of photodynamic therapy in patients with chronic central serous chorioretinopathy (CSCRP) without choroidal neovascularization. Relevance. Central serous chorioretinopathy, especially the chronic form, remains an urgent problem in ophthalmology. To date, various methods of treating this pathology have been proposed, the main of which are conservative therapy and laser treatment. The latter includes Transpupillary Thermotherapy (TTT), Micropulse Laser Treatment and Photodynamic Therapy (PDT). Unfortunately, not one technique today can claim the title of

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Mirkhalikov, F. R., A. F. Yusupov, and K. S. Ashirmatova. "Laser photodynamic therapy in the treatment of chronic central serous chorioretinopathy without choroidal neovascularization." Modern technologies in ophtalmology, no. 1 (March 25, 2022): 217–21. http://dx.doi.org/10.25276/2312-4911-2022-1-217-221.

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Purpose. To estimate preliminary results of photodynamic therapy in patients with chronic central serous chorioretinopathy (CSCRP) without choroidal neovascularization. Relevance. Central serous chorioretinopathy, especially the chronic form, remains an urgent problem in ophthalmology. To date, various methods of treating this pathology have been proposed, the main of which are conservative therapy and laser treatment. The latter includes Transpupillary Thermotherapy (TTT), Micropulse Laser Treatment and Photodynamic Therapy (PDT). Unfortunately, not one technique today can claim the title of

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Vasileuski, A. P., N. A. Artemova, T. M. Litvinova, I. A. Kosenko, and E. N. Alexandrova. "PHOTODYNAMIC THERAPY IN MULTIMODALITY TREATMENT OF PLISS LYMPHOSARCOMA AND UTERINE CERVIX CANCER-5." Journal of the Grodno State Medical University 18, no. 6 (2020): 676–80. http://dx.doi.org/10.25298/2221-8785-2020-18-6-676-680.

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Background. Malignant tumors management using conventional treatment modalities is associated with poor outcomes. Objective of the study. To assess photodynamic activity of Photolon as monotherapy, as well as in combination with radio- and chemotherapy in an experiment.Material and methods. The research was done on HeLa monolayer culture (human uterine cervix carcinoma), 97 white random-bred rats with Pliss lymphosarcoma and 42 mice (CBA) with uterine cervix cancer-5 (UCC-5). Results. The amplification factor in Photolon photoirradiation was 65.1 in terms of the cytostatic effect and 98.5 in t

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Шило, Р. С., Н. И. Батвинков, Э. В. Могилевец, Н. И. Прокопчик, К. С. Белюк, and О. С. Сорока. "Endocholedocheal Introduction of Photolonin the Experiment: Distribution along the Biliary System and Accumulation in the Duct Wall." Хирургия. Восточная Европа, no. 4 (February 2, 2021): 328–37. http://dx.doi.org/10.34883/pi.2020.9.4.014.

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Введение. Антимикробная фотодинамическая терапия воспалительных заболеваний желчевыводящей системы предполагает введение фотосенсибилизатора внутрь общего желчного протока. При таком пути введения препарата малоизученным является его накопление в стенке желчных протоков, дискутабельным остается вопрос о создаваемом давлении внутри протока и времени экспозиции фотосенсибилизатора.Цель. Оценить в эксперименте накопление в стенке желчных протоков фотосенсибилизатора Фотолон, введенного эндохоледохеально, и его распространение по желчевыводящей системе. Материалы и методы. Первой опытной группе жи

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Vasilev, L. A., N. S. Panov, V. N. Kapinus, M. A. Kaplan, I. P. Kostyuk, and A. D. Kaprin. "Intraoperative fluorescent spectroscopy and photodynamic therapy of recurrent pelvis minor tumors with local radiation damage." Biomedical Photonics 7, no. 3 (2018): 21–28. http://dx.doi.org/10.24931/2413-9432-2018-7-3-21-28.

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This work presents the results of performing intraoperative photodynamic therapy (IOPDT) on 22 patients with recurrent pelvic tumors(cervical cancer – in 18 patients, cancer of the corpus uteri – in 3 patients, cancer of the anal canal – in 1 patient). Prior to the PDT procedure, the patients were injected with photolon photosensitizer (PS) at a dose of 1.0–1.1 mg/kg. After the injection of PS, local fluorescence spectroscopy of tumor lesions was performed to determine the accumulation of drug in various areas of tumors and healthy tissue. Intraoperative laser irradiation was carried out 3–5 h

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Lavrenchuk, G. Y., V. V. Talko та A. V. Chernyshov. "EFFECTIVENESS OF THE PHOTON CAPTURE BEAM TECHNOLOGY AND PHOTODYNAMIC IMPACT ON MALIGNANT HUMAN CELLS ІN A RESTING STATE". Проблеми радіаційної медицини та радіобіології = Problems of Radiation Medicine and Radiobiology 28 (2023): 206–15. http://dx.doi.org/10.33145/2304-8336-2023-28-206-215.

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Objective: to investigate the structural and morphofunctional changes in test system of malignant (cell line A-549) human cells in a resting state exposed to X-rays in the presence of gadolinium-containing photon capture agent «Dotavist» and optical light (red spectrum) in combination with «Photolon» photosensitizer. Methods. Passaged malignant human cell culture technology, X-ray and red light exposure, cytological and statistical methods. Results. X-ray exposure at a dose of 10.0 Gy in the presence of photon capture agent «Dotavist» (at a 100 μg/ml nutrient medium concentration) led to death

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Kapinus, V. N., M. A. Kaplan, E. V. Yaroslavtseva-Isayeva, I. S. Spichenkova, and S. A. Ivanov. "Chlorin E6-photodynamic therapy basal cell carcinoma." Research and Practical Medicine Journal 8, no. 4 (2021): 33–43. http://dx.doi.org/10.17709/2410-1893-2021-8-4-3.

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Purpose of the study. Evaluation of the therapeutic efficacy of chlorin E6-photodynamic therapy (PDT) with photosensitizers (PS) photoditazine, photolone and photoran in patients suffering basal cell skin carcinoma.Materials and methods. The efficacy of chlorin E6-PDT was studied in 532 patients with basal cell skin cancer (BCC) aged 28 to 93 years. PhS Photoditazine was used in 72 (13,5 %) patients at a dose of 0.5-1.0 mg/kg, PhS Photolon - in 281 (52,8 %) patients at a dose of 1.1-1.6 mg/kg and PhS Photoran - in 179 (33,6 %) people at a dose of 1.1-1.6 mg/kg.Sessions of local irradiation of

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Pochapinskyi, O., G. Lavrenchuk, N. Atamaniuk, and A. Chernyshov. "SELECTION AND TESTING OF EXPERIMENTAL MODELS OF NORMAL AND MALIGNANT HUMAN CELLS IN VITRO AND EVALUATION OF THEIR SENSITIVITY RANGE TO THE NEUTRON/CAPTURE AND PHOTON-CAPTURE AGENTS AND PHOTOSENSITIZERS." Проблеми радіаційної медицини та радіобіології = Problems of Radiation Medicine and Radiobiology 26 (2021): 260–72. http://dx.doi.org/10.33145/2304-8336-2021-26-260-272.

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Objective: to investigate the structural and morpho-functional changes in test systems of malignant (A-549 cell line) and normal (fibroblasts of the 6th passage) human cells during incubation with gadolinium-containing photon-capture agent «Dotavist» and photosensitizer «Fotolon». Methods. The passaged (continuously interweaved) cell culture technique on normal human fibroblasts and malignant human cells; cytological, biophysical, statistical methods. Results. The cytotoxic properties of «Dotavist» gadolinium-containing photon-capturing agent and «Photolon» photosensitizer in a wide range of c

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Istomin, Yu P., T. P. Artemyeva, and D. A. Tzerkovsky. "Photodynamic therapy with photosensitizer photolon for oral leukoplakia." Biomedical Photonics 5, no. 2 (2016): 13–20. http://dx.doi.org/10.24931/2413-9432-2016-5-2-13-20.

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Dmitry, Tzerkovsky. "Photodynamic Therapy for Vulvar Carcinoma in situ (Case Report)." Journal of Cancer and Tumor International 5, no. 3 (2017): 1–5. https://doi.org/10.9734/JCTI/2017/33532.

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The article presents a clinical case of the successful application of photodynamic therapy with chlorine e6-based photosensitizer photolon in a patient with vulvar cancer in situ. The use of an exposure dose of light of 100 J/cm<sup>2</sup> made it possible to achieve complete clinical and morphological regression of the pathological focus, confirmed by control observations at 3 and 6 months.

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Buzalewicz, Igor, Iwona Hołowacz, Anna K. Matczuk, et al. "Photolon Nanoporous Photoactive Material with Antibacterial Activity and Label-Free Noncontact Method for Free Radical Detection." International Journal of Molecular Sciences 23, no. 1 (2021): 279. http://dx.doi.org/10.3390/ijms23010279.

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The worldwide increase in bacterial resistance and healthcare-associated bacterial infections pose a serious threat to human health. The antimicrobial photodynamic method reveals the opportunity for a new therapeutic approach that is based on the limited delivery of photosensitizer from the material surface. Nanoporous inorganic–organic composites were obtained by entrapment of photosensitizer Photolon in polysiloxanes that was prepared by the sol–gel method. The material was characterized by its porosity, optical properties (fluorescence and absorbance), and laser-induced antimicrobial activi

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Tzerkovsky, D. A., A. N. Mazurenko, N. A. Petrovskaya, and T. P. Artemyeva. "PHOTODYNAMIC THERAPY WITH PHOTOSENSITIZER PHOTOLON FOR BASAL CELL CARCINOMA." Biomedical Photonics 6, no. 1 (2017): 12–19. http://dx.doi.org/10.24931/2413-9432-2017-6-1-12-19.

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Shyla, R. S., E. М. Mahiliavets, K. S. Belyuk, N. I. Procopchik, and V. V. Vashchanka. "PHOTODYNAMIC THERAPY OF EXPERIMENTAL CHOLANGITIS." Journal of the Grodno State Medical University 19, no. 1 (2021): 96–105. http://dx.doi.org/10.25298/2221-8785-2021-19-1-96-105.

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Background. Photodynamic therapy of acute cholangitis involves the introduction of a photosensitizer into the common bile duct and subsequent laser irradiation of the liver. The study of combined laser action on the liver is promising. Purpose of the study. To evaluate in an experiment the effectiveness of photodynamic therapy of acute cholangitis with the introduction of a photosensitizer into the common bile duct and combined laser irradiation of the liver. Material and methods. Acute cholangitis was modeled in rabbits. In the first group, a saline solution was introduced into the common bil

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Tzerkovsky, P. "40 sonodynamic therapy with photolon for intracranial glioma C6 in rats." Photodiagnosis and Photodynamic Therapy 9 (August 2012): S14. http://dx.doi.org/10.1016/s1572-1000(12)70041-8.

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Cyboran-Mikołajczyk, Sylwia, Przemysław Sareło, Robert Pasławski, et al. "Impact of Liposomal Drug Formulations on the RBCs Shape, Transmembrane Potential, and Mechanical Properties." International Journal of Molecular Sciences 22, no. 4 (2021): 1710. http://dx.doi.org/10.3390/ijms22041710.

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Liposomal technologies are used in order to improve the effectiveness of current therapies or to reduce their negative side effects. However, the liposome–erythrocyte interaction during the intravenous administration of liposomal drug formulations may result in changes within the red blood cells (RBCs). In this study, it was shown that phosphatidylcholine-composed liposomal formulations of Photolon, used as a drug model, significantly influences the transmembrane potential, stiffness, as well as the shape of RBCs. These changes caused decreasing the number of stomatocytes and irregular shapes

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Istomin, Y. P., T. P. Lapzevich, V. N. Chalau, S. V. Shliakhtsin, and T. V. Trukhachova. "Photodynamic therapy of cervical intraepithelial neoplasia grades II and III with Photolon®." Photodiagnosis and Photodynamic Therapy 7, no. 3 (2010): 144–51. http://dx.doi.org/10.1016/j.pdpdt.2010.06.005.

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Zhang, Shuai, Xincheng Wang, Wenbin Jiang, Yizhu Zhang, Yuhai Jiang, and Zhiyuan Zhu. "Charge-encoded multi-photoion coincidence for three-body fragmentation of CO₂ in the strong laser fields." Journal of Chemical Physics 156, no. 13 (2022): 134302. http://dx.doi.org/10.1063/5.0085539.

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The photoion–photoion coincidence (PIPICO) is a simple and effective approach for the selection of correlated fragments in a specific dissociating channel in molecules. We propose here a charge-encoded multi-photoion coincidence (cMUPICO) method, in analogy to traditional PIPICO, however in which the charge of individual fragments is taken into account. The cMUPICO method allows for clearly displaying coincident channels for dissociation channels containing three more fragments with unequal charge states, invisible in the traditional PIPICO. As a demonstration, three-body fragmentation dynamic

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Shliakhtsin, S. V., T. V. Trukhachova, H. A. Isakau, and Y. P. Istomin. "Pharmacokinetics and biodistribution of Photolon® (Fotolon®) in intact and tumor-bearing rats." Photodiagnosis and Photodynamic Therapy 6, no. 2 (2009): 97–104. http://dx.doi.org/10.1016/j.pdpdt.2009.04.002.

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Tzerkovsky, D., E. Alexandrova, V. Chalau, and Y. Istomin. "Sonodynamic therapy enhance Photolon-mediated photodynamic therapy of rat brain tumor model glioma C6." Photodiagnosis and Photodynamic Therapy 8, no. 2 (2011): 164. http://dx.doi.org/10.1016/j.pdpdt.2011.03.135.

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Podbielska, Halina, Agnieszka Ulatowska-Jarza, Gerhard Müller, Iwona Holowacz, Joanna Bauer, and Uwe Bindig. "Silica sol–gel matrix doped with Photolon molecules for sensing and medical therapy purposes." Biomolecular Engineering 24, no. 5 (2007): 425–33. http://dx.doi.org/10.1016/j.bioeng.2007.07.005.

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Krochek, I. V., R. D. Ibatullin, A. V. Lappa, and A. E. Anchugova. "Outcomes after intraoperative photodynamic therapy in the combined treatment of locally advanced colon cancer." Laser Medicine 27, no. 2 (2023): 8–15. http://dx.doi.org/10.37895/2071-8004-2023-27-2-8-15.

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Purpose. To study outcomes after the combined treatment of locally advanced colon cancer with intraoperative photodynamic therapy. Materials and methods. 35 patients with locally advanced colon cancer were included in the trial. Patients from the main group (n = 17) had intraoperative photodynamic therapy in combination with elective surgery. Patients from the control group (n = 18) had only surgical treatment. For photodynamic therapy, photosensitizer Photolon and “Lakhta-Milon” diode laser with wavelength 662 nm and power up to 2.5 W were used. Laser light was delivered via a quartz polymer

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Shanazarov, N. A., B. G. Kassymov, T. M. Muratov, and S. V. Zinchenko. "Photodynamic therapy of penile leukoplakia: a case report." Laser Medicine 25, no. 3 (2022): 29–33. http://dx.doi.org/10.37895/2071-8004-2021-25-3-29-33.

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Purpose: to describe a clinical case of successful application of photodynamic therapy (PDT) in a patient with leukoplakia of the glans penis skin.Material and methods. For PDT, chlorin-type photosensitizer “Photolon” was used. The photosensitizer (lyophilized powder) was diluted in 200.0 ml of 0.9 % sodium chloride solution, administered intravenously at dosage 1.5 mg/kg of body weight. After 2.5 hours, intravenous laser blood irradiation was performed with “Lakhta-Milon” laser device (output power – 100 mW, exposure – 30 minutes). Before PDT, ﬂuorescence diagnostics in ultraviolet light with

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Polkin, V., M. Kaplan, V. Medvedev, et al. "Photodynamic therapy in the treatment of oral cancer with Photolon: An analysis of 51 cases." Photodiagnosis and Photodynamic Therapy 8, no. 2 (2011): 168. http://dx.doi.org/10.1016/j.pdpdt.2011.03.147.

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Samtsov, M. P., D. S. Tarasau, K. N. Kaplevsky, E. S. Voropay, P. T. Petrov, and Yu P. Istomin. "Fluorescence Diagnosis of Damage to Tumor Tissues During Photodynamic Therapy with the Photosensitizer Photolon®." Journal of Applied Spectroscopy 83, no. 1 (2016): 79–84. http://dx.doi.org/10.1007/s10812-016-0246-9.

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Ali Abd El-karem, Samir, Gihan Hosny Abd Elsamie, and Ghufran Abbas Isewid. "Laser and Ultrasound Activated Photolon Nanocomposite in Tumor-Bearing Mice: New Cancer Fighting Drug-Technique." Archives of Oncology and Cancer Therapy 2, no. 1 (2019): 1–15. http://dx.doi.org/10.22259/2638-5074.0201001.

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Dunaievska, V. V., and Ye O. Horkavyi. "An assessment of photodynamic therapy efficacy for the treatment of Bowen’s disease of the vulva." Zaporozhye Medical Journal 24, no. 1 (2022): 49–55. http://dx.doi.org/10.14739/2310-1210.2022.1.239492.

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Vulvar cancer occupied the 4th place (3–8 %) in the distribution of the malignant neoplasms of female genital organs, although this disease is considered to be rare. In the United States, about 4,000 new cases of vulvar cancer are diagnosed every year, and 850 women die from this cancer. An estimated 650 new cases of this disease are reported per year in Ukraine. One of the precancerous lesions of the vulva along with Paget’s disease is Bowen’s disease, which can progress to squamous cell carcinoma. Photodynamic therapy (PDT) is regarded as an effective method of this disease treatment in the

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Ivanova, Viktoria A., Ekaterina V. Verenikina, Vera P. Nikitina, Oksana E. Zhenilo, and Anna Yu Ardzha. "Photodynamic therapy for preinvasive vaginal cancer." Journal of Clinical Oncology 39, no. 15_suppl (2021): 5592. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.5592.

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5592 Background: Photodynamic therapy (PDT) is an effective method for the treatment of various cancers resulting in apoptosis, autophagy and ischemic necrosis of irradiated tissues. The purpose of the study was to analyze the efficacy of PDT for pre-invasive vaginal cancer treatment. Methods: PDT results were studied in 20 patients aged 32-65 years with verified pre-invasive vaginal cancer. All patients received PDT with the Latus diode laser and Photolon or Photolan photosensitizers. The effect was evaluated with extended colposcopy. The criteria for efficiency included normalization of the

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Ulatowska-Jarża, A., J. Pucińska, K. Wysocka-Król, I. Hołowacz, and H. Podbielska. "Nanotechnology for biomedical applications - enhancement of photodynamic activity by nanomaterials." Bulletin of the Polish Academy of Sciences: Technical Sciences 59, no. 3 (2011): 253–61. http://dx.doi.org/10.2478/v10175-011-0031-0.

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Nanotechnology for biomedical applications - enhancement of photodynamic activity by nanomaterialsOver the last two decades nanotechnology has become one of the most dynamically evolving field of research. The unique properties of nanomaterials, not disclosing at microscale, are examined and exploited to extend our understanding of the interactions taking place at atomic or molecular level. Those findings affect research in many areas, like e.g. alternative energy sources, electronics, physics and medicine. In this paper, the possibility of using nanomaterials for the enhancement of photodynam

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Bindig, U., A. Ulatowska-Jarza, M. Kopaczynska, G. Müller, and H. Podbielska. "Investigations on photolon-and porphyrin-doped sol-gel fiberoptic coatings for laser-assisted applications in medicine." Laser Physics 18, no. 1 (2008): 63–72. http://dx.doi.org/10.1134/s1054660x08010118.

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Bagrov, I. V., I. M. Belousova, A. V. Dadeko, et al. "Optical and photophysical properties of the chlorin-type photosensitizer photolon in aqueous solutions of different acidities." Optics and Spectroscopy 123, no. 3 (2017): 392–98. http://dx.doi.org/10.1134/s0030400x17090041.

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Parkhots, M. V., V. N. Knyukshto, G. A. Isakov, et al. "Spectral-Luminescent Studies of the “Photolon” Photosensitizer in Model Media and in Blood of Oncological Patients." Journal of Applied Spectroscopy 70, no. 6 (2003): 921–26. http://dx.doi.org/10.1023/b:japs.0000016312.04644.c7.

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Fedulov, A. S., S. V. Shliakhtsin, T. V. Trukhachova, et al. "Efficacy of the adjuvant intraoperative photodynamic therapy with Photolon® in patients with malignant brain tumors." Photodiagnosis and Photodynamic Therapy 8, no. 2 (2011): 164–65. http://dx.doi.org/10.1016/j.pdpdt.2011.03.137.

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Parkhats, M. V., V. A. Galievskii, E. S. Zharnikova, et al. "Dynamics of photosensitized singlet oxygen generation and photophysical characteristics of chlorin e 6 in photolon ointment." Journal of Applied Spectroscopy 78, no. 2 (2011): 278–85. http://dx.doi.org/10.1007/s10812-011-9459-0.

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Copley, Louise, Pauline van der Watt, Karel W. Wirtz, M. Iqbal Parker, and Virna D. Leaner. "Photolon™, a chlorin e6 derivative, triggers ROS production and light-dependent cell death via necrosis." International Journal of Biochemistry & Cell Biology 40, no. 2 (2008): 227–35. http://dx.doi.org/10.1016/j.biocel.2007.07.014.

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Chudnykh, S. M., V. S. Egorov, Kh A. Abduvosidov, A. V. Snitsar, I. A. Chekmareva, and A. Emaimo John. "Doxorubicin enhanced the antitumor efficacy of sonodynamic therapy with photosensitizer photolon in an in vivo experiment." Biomedical Photonics 14, no. 1 (2025): 29–35. https://doi.org/10.24931/2413-9432-2025-14-1-29-35.

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An experimental model of an infected wound was created in 90 Wistar rats using a mixture of cultures of Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Candida albicans. The animals are divided into 3 groups of 30 individuals. The first group consisted of animals treated with pulsed high-intensity broadband irradiation using an experimental apparatus with a pulsed xenon lamp operating in a pulsed periodic mode with an average UV-C (200-280 nm) radiation power of 3 W, and a pulsed UV-C power of 24 kW. In the second group, traditional ultraviolet irradiation of wounds w

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Kapinus, V. N., O. B. Karyakin, E. V. Yaroslavtseva-Isaeva, O. E. Popovkina, S. A. Ivanov, and А. D. Kaprin. "Experience of using photodynamic therapy in early stages of penile cancer." Cancer Urology 18, no. 3 (2022): 99–106. http://dx.doi.org/10.17650/1726-9776-2022-18-3-99-106.

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Background. Penile cancer is a rare oncological pathology. Due to the intimate nature of the affected area and high significance of the organ for psycho-emotional state of the patient, at the early stages of the disease organ-sparing operations are preferred allowing to minimize the effect on patient’s quality of life without affecting oncological results.Aim. To evaluate the effectiveness of treatment of early stages penile cancer using photodynamic therapy (PDT) with chlorin E6 derivatives.Materials and methods. Between 2017 and 2021, PDT with chlorin E6 derivatives to treat early-stage peni

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Sliakhtsin, S. V., A. V. Kuvshinov, T. V. Trukhachova, and S. A. Naumovich. "32 EXPERIMENTAL STUDY OF Photolon®/Fotolon® OINTMENT AS A REMEDY FOR PHOTODYNAMIC THERAPY IN STOMATOLOGY." Photodiagnosis and Photodynamic Therapy 5 (August 2008): S12. http://dx.doi.org/10.1016/s1572-1000(08)70034-6.

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Tzerkovsky, D. A., Yu P. Istomin, T. P. Artemieva, Yu N. Grachev, and F. F. Borichevsky. "Sono-Photodynamic Therapy with Photolon for Recurrence Glioblastoma Grade IV: Case Report and Review of Experimental Studies." Journal of Analytical Oncology 5, no. 2 (2016): 62–66. http://dx.doi.org/10.6000/1927-7229.2016.05.02.3.

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Parkhots, M. V., V. A. Lapina, D. N. Butorina, et al. "Spectral and photochemical characteristics of the photosensitizers chlorin e 6 and photolon in the presence of melanin." Optics and Spectroscopy 98, no. 3 (2005): 374–82. http://dx.doi.org/10.1134/1.1890515.

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Kosenko, I. A., Y. P. Istomin, T. P. Laptsevich, V. N. Chalov, and R. M. Smolyakova. "ANTITUMORAL AND ANTIVIRAL EFFECTIVENESS OF PHOTODYNAMIC THERAPY IN PATIENTS WITH CERVICAL INTRAEPITHELIAL NEOPLASIA II-III SUFFERED FROM PHOTOLON." Health and Ecology Issues, no. 1S (December 28, 2010): 27–30. http://dx.doi.org/10.51523/2708-6011.2010-7-1s-7.

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The method of photodynamic therapy has been elaborated, studied experimentally and tested in a clinic in 112 patients with CIN II-III. The method of photodynamic therapy included two stages: administration of photosensybilizator фотосенсибилизатора and radiation treatment with a laser of long length, corresponding to the peak of the absorption of the medicine. The following theses were established: photodynamic therapy of CIN contributes to the decrease of the number of HPV-positive patients (from 81,2 to 56 %), the clinical effectiveness photodynamic therapy of CIN corresponds to 92,8 % of th

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Fedulov, A. S., I. I. Sakovich, S. V. Sliakhtsin, and T. V. Trukhachova. "19 PHOTODYNAMIC THERAPY OF HIGH GRADE GLIOMAS WITH PHOTOLON®/FOTOLON®. RESULTS OF AN OPEN-LABEL CLINICAL TRIAL." Photodiagnosis and Photodynamic Therapy 5 (August 2008): S7. http://dx.doi.org/10.1016/s1572-1000(08)70021-8.

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Yevcheva, Anhelina, Serhii Pukhlik, and Dilyana Vicheva. "Fluorescent border diagnosis and surgical treatment of the malignant process of external nose skin." Romanian Journal of Rhinology 12, no. 45 (2022): 37–42. http://dx.doi.org/10.2478/rjr-2022-0006.

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Abstract OBJECTIVE. The purpose of the study was to find out the diagnostic value of the Photolon® as a fluorescent visualization of the borders of malignant lesions of the external nose, with the aim of radical surgical removal of the tumor. MATERIAL AND METHODS. During the period from 2016 until 2018, 30 patients with malignant neoplasms of the external nose were examined and operated on in the Otolaryngology-Head and Neck Department. During the study, patients underwent surgical removal of tumors by using a complex of anemic Klein’s solution and fluorescent imaging of the lesion in 15 patie

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Kapinus, V. N., M. A. Kaplan, E. V. Yaroslavtseva-Isayeva, I. S. Spichenkova, A. D. Kaprin, and S. A. Ivanov. "Photodynamic therapy as a treatment option for skin cancer, developed on scars." Laser Medicine 24, no. 4 (2021): 54–61. http://dx.doi.org/10.37895/2071-8004-2020-24-4-54-61.

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It is given a literature reference on the etiology, frequency and mechanisms of development, features of the clinical presentation and treatment options for skin cancer that has developed on scars. It is presented a detailed clinical observation of a patient with squamous cell skin cancer in the area of the right elbow joint, which occurred 67 years after the kerosene lamp burns of the skin of the right upper limb and the right half of the chest. The patient was initially treated with electron radiotherapy in the total focal dose 60 Gy with a partial effect, but after 10 months a relapse was d

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Artemyeva, T. Р., and D. A. Tzerkovsky. "Photodynamic therapy for vulvar leukoplakia." Biomedical Photonics 7, no. 4 (2019): 4–10. http://dx.doi.org/10.24931/2413-9432-2018-7-4-4-10.

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The aim of study is to evaluate the tolerability and eﬀectiveness of photodynamic therapy as an organ‑preserving treatment in patients with vulvar leukoplakia. 50 patients with a verifed diagnosis of «vulvar leukoplakia» were included in the study. The age varied from 27 to 74 years. The method of treatment assumed the use of the photosensitizer рhotolon (RUE «Belmedpreparaty», Belarus) administered intravenously in doses of 1.8–2.5 mg/kg. Photoirradiation of pathological foci was carried out 2.5–3 hours after intravenous injection of photolon® using a semiconductor laser «UPL PDT» (LEMT, Bela

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Kruczek-Kazibudzka, Anna, Barbara Lipka, Jakub Fiegler-Rudol, Marcin Tkaczyk, Dariusz Skaba, and Rafał Wiench. "Toluidine Blue and Chlorin-e6 Mediated Photodynamic Therapy in the Treatment of Oral Potentially Malignant Disorders: A Systematic Review." International Journal of Molecular Sciences 26, no. 6 (2025): 2528. https://doi.org/10.3390/ijms26062528.

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Oral potentially malignant disorders (OPMDs) are conditions that carry an increased risk of malignant transformation, including oral leukoplakia and oral lichen planus. Current management approaches differ based on each condition’s unique etiology and pathophysiology, but all available treatment methods have notable limitations. This has prompted continued efforts to identify more effective therapeutic options. Photodynamic therapy (PDT) has emerged as a minimally invasive yet potent alternative for treating OPMDs. This systematic review examines the efficacy of PDT mediated by toluidine blue

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