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Journal articles on the topic 'Phthalimidc'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Aly, A. A., H. M. Ammar, and A. A. Khalil. "Copolymerization Parameters of 2-(N-Phthalimido) ethyl Methacrylate with Different Vinyl Monomers." Material Science Research India 8, no. 1 (2011): 17–24. http://dx.doi.org/10.13005/msri/080103.

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2-(N-phthalimido)ethyl methacrylate was prepared by the reaction of methacrylic acid with N-(2-hydroxyethyl)phthalimide in presence of N,N?-dicyclohexylcarbodiimide. The monomer reactivity ratios for copolymerization reactions of 2-(N-phthalimido)ethyl methacrylate with methyl acrylate, ethyl acrylate, butyl acrylate and styrene, respectively, in solution with azobisisobutyronitrile (AIBN) as initiator, were estimated by nitrogen analysis. The structure of the copolymers was investigated by IR spectroscopy. The Q and e values for 2-(N-phthalimido)ethyl methacrylate were calculated. Some of the

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2

Basu, Souradeep, Alexander H. Sandtorv, and David R. Stuart. "Imide arylation with aryl(TMP)iodonium tosylates." Beilstein Journal of Organic Chemistry 14 (May 11, 2018): 1034–38. http://dx.doi.org/10.3762/bjoc.14.90.

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Herein, we describe the synthesis of N-aryl phthalimides by metal-free coupling of potassium phthalimide with unsymmetrical aryl(TMP)iodonium tosylate salts. The aryl transfer from the iodonium moiety occurs under electronic control with the electron-rich trimethoxyphenyl group acting as a competent dummy ligand. The yields of N-aryl phthalimides are moderate to high and the coupling reaction is compatible with electron-deficient and sterically encumbered aryl groups.

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3

Oksdath-Mansilla, Gabriela, Adrián A. Heredia, Juan E. Argüello, and Alicia B. Peñéñory. "Photochemistry of N-(selenoalkyl)-phthalimides. Formation of N, Se-heterocyclic systems." Photochemical & Photobiological Sciences 14, no. 4 (2015): 726–36. http://dx.doi.org/10.1039/c4pp00452c.

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A number of selenium heterocyclic derivatives are obtained upon direct or acetone-sensitized irradiation of a variety ofN-(selenomethyl)alkyl-phthalimides. The reaction proceeds by photoinduced intramolecular electron transfer between the Se atom and the phthalimide moiety.

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4

Chetna, Ameta, Ameta Rakshit, Tiwari Urvashi, B. Punjabi P., and C. Ameta Suresh. "Enviro-economic synthesis of some phthalimide derivatives using microwave irradiation." Journal of Indian Chemical Society Vol. 88, Jun 2011 (2011): 827–33. https://doi.org/10.5281/zenodo.5770152.

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Microwave Chemistry Laboratory, Department of Chemistry, Mohanlal Sukhadia University, Udaipur-313 001, Rajasthan, India <em>E-mail</em> : ameta_sc@yahoo.com Department of Pure and Applied Chemistry, University of Kota, Kota-324 005, Rajasthan. India <em>Manuscript received 14 June 2010, accepted 28 October 2010</em> An environmentally benign, efficient and facile route is developed for the preparation of phthalimide derhatives by using LiBr as a catalyst under solvent free condition and microwave exposure. In comparison to conventional synthesis involving tedious workup, excessive use of solv

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5

Hasaninejad, Alireza, Abdolkarim Zare, Ahmad Reza Moosavi-Zare, Fatemeh Khedri, Rahimeh Rahimi, and Ali Khalafi-Nezhad. "Cs2CO3/[bmim]Br as an Efficient, Green, and Reusable Catalytic System for the Synthesis of N-Alkyl Derivatives of Phthalimide under Mild Conditions." Research Letters in Organic Chemistry 2008 (December 18, 2008): 1–4. http://dx.doi.org/10.1155/2008/419054.

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Aza-conjugate addition of phthalimide to α,β-unsaturated esters efficiently achieves in the presence of catalytic amount of Cs2CO3 and ionic liquid 1-butyl-3-methylimidazolium bromide ([bmim]Br) under mild reaction conditions (70°C) to afford N-alkyl phthalimides in high yields and relatively short reaction times.

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6

Bogdan, Anca, Myroslav O. Vysotsky, and Volker Böhmer. "Selective Derivatization of Calix[4]arenes via Amino Groups Attached to the Wide Rim." Collection of Czechoslovak Chemical Communications 69, no. 5 (2004): 1009–26. http://dx.doi.org/10.1135/cccc20041009.

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A new strategy is proposed for the synthesis of tetraether derivatives of calix[4]arenes bearing at the wide rim nitro and phthalimido groups in well defined positions. Since both groups are precursors of amino functions, calix[4]arenes substituted by different N-acylamino residues are easily available in four steps. The essential steps during the synthesis of the precursor consist in the protection of amino groups by the formation of their phthalimides followed by ipso-nitration of the remaining tert-butylphenol ether units. This nitration occurs without side reactions at the phthalimido subs

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7

Gramage-Doria, Rafael, Yu-Chao Yuan, and Christian Bruneau. "Merging Transition-Metal Catalysis with Phthalimides: A New Entry to Useful Building Blocks." Synthesis 50, no. 21 (2018): 4216–28. http://dx.doi.org/10.1055/s-0037-1610282.

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Phthalimides have found their main application in organic synthesis as protecting groups for primary amines during the multistep synthesis of biologically relevant targets. On the other hand, phthalimide functionalization is rather challenging and it is traditionally associated with the use of over-stoichiometric amounts of environmentally hazardous reagents. In this short review, we describe and discuss how, in the last decades, transition-metal catalysts have provided useful organic building blocks after selective transformation of the phthalimide skeleton in a more efficient and sustainable

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8

Jourdain, Isabelle, Michael Knorr, Tom Charenton, Carsten Strohmann, Jan-Lukas Kirchhoff та Mohamed Othman. "(µ2-η4-N-(2-Butynyl)phthalimide)(hexacarbonyl)dicobalt". Molbank 2023, № 1 (2023): M1545. http://dx.doi.org/10.3390/m1545.

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The reaction of [Co2(CO)8] with an equimolar amount of the internal alkyne N-(2-butynyl)phthalimide (1-Phthalimido-2-butyne) 1 in heptane solution yields the title compound [Co2(CO)6(µ-phthalimidoCH2C≡CMe)] 2. Compound 2 has been characterized using IR, 1H and 13C NMR spectroscopy; the tetrahedrane-type cluster framework has been ascertained using a single-crystal X-ray diffraction study performed at 100 K.

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9

Le, Zhang Gao, Tao Zhong, Zong Bo Xie, and Jiang Ping Xu. "Solvent-Free N-Alkylation of Phthalimide Catalyzed by Basic Ionic Liquids." Advanced Materials Research 233-235 (May 2011): 1431–34. http://dx.doi.org/10.4028/www.scientific.net/amr.233-235.1431.

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Solvent-freeN-alkylation of phthalimide with alkyl halides catalyzed by basic ionic liquids was developed in this conmmunication. With a comparative study, [Bmim]OH (1-butyl-3-methyl imidazolium hydroxide) exhibited the highest catalytic activity among the selected basic ionic liquids, which afforded a convenient, efficient and general protocol forN-alkyl phthalimides exclusively.

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10

Zhao, Xue. "Synthesis and application of N-butyl substituted phthalimide disperse dyes." Textile Research Journal 89, no. 15 (2018): 3034–47. http://dx.doi.org/10.1177/0040517518805380.

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Three azo dyes were synthesized using N-butyl substituted phthalimides as diazo components. All of the synthesized intermediate derivatives and dyes were characterized by mass spectrometry, proton nuclear magnetic resonance, infrared (IR) and elemental analyses. Synthesized dyes were also evaluated for their dyeing behavior and fastness properties toward polyester fabric. The ultraviolet-visible absorption maxima of the dyes were observed in the range of 445–563 nm. Bromo and cyano substitutions at the 3- and/or 5- positions of the phthalimide ring resulted in hypsochromic and bathochromic shi

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11

Sayali Ulhas Vishe, Rahul Prakash Lokhande, Sayali Adinath Wagh, Saniya Dastagir Pathan, and Samrin Rafik Pathan. "An in-depth review of thalidomide's basic moieties." World Journal of Biology Pharmacy and Health Sciences 18, no. 2 (2024): 102–9. http://dx.doi.org/10.30574/wjbphs.2024.18.2.0250.

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Thalidomide, also referred to as N-phthalimido glutarimide, was initially made available as a sedative by Chemie Grunelthal GmbH in West Germany in 1957. Thalidomide's chemical structure primarily consists of two rings: the phthalimide ring and the glutarimide ring. Although small substitutions in one or both rings might be tolerated without a reduction in toxicity, both of these groups were necessary for embryopathic action. A cyclic chemical structure that is a component of thalidomide is the phthalimide ring. The phthalimide ring is thought to contribute to both the teratogenic (causes birt

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12

Sayali, Ulhas Vishe, Prakash Lokhande Rahul, Adinath Wagh Sayali, Dastagir Pathan Saniya, and Rafik Pathan Samrin. "An in-depth review of thalidomide's basic moieties." World Journal of Biology Pharmacy and Health Sciences 18, no. 2 (2024): 102–9. https://doi.org/10.5281/zenodo.13734152.

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Thalidomide, also referred to as N-phthalimido glutarimide, was initially made available as a sedative by Chemie Grunelthal GmbH in West Germany in 1957. Thalidomide's chemical structure primarily consists of two rings: the phthalimide ring and the glutarimide ring. Although small substitutions in one or both rings might be tolerated without a reduction in toxicity, both of these groups were necessary for embryopathic action. A cyclic chemical structure that is a component of thalidomide is the phthalimide ring. The phthalimide ring is thought to contribute to both the teratogenic (causes birt

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13

Journal, Baghdad Science. "Synthesis, Characterization and Antimicrobial Screening of New Schiff Bases Linked to Phthalimidyl Phenyl Sulfonate Moiety." Baghdad Science Journal 11, no. 2 (2014): 438–46. http://dx.doi.org/10.21123/bsj.11.2.438-446.

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A series of Schiff bases linked to phthalimidyl phenyl sulfonate moiety have been synthesized via multistep synthesis. The first step involved reaction of phthalic anhydride with aniline producing N-phenyl phthalamic acid which was subsequently dehydrated to the corresponding N-phenyl phthalimide via treatment with acetic anhydride and anhydrous sodium acetate. The synthesized imide was treated with chlorosulfonic acid in the third step producing 4-(N-phthalimidyl) phenyl sulfonyl chloride which was introduced in reaction with 4-hydroxy acetophenone in the fourth step producing 4-[4-(N-phthali

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14

Al-Azzawi, Ahlam M., and Marwa S. Abd Al-Razzak. "Synthesis, Characterization and Antimicrobial Screening of New Schiff Bases Linked to Phthalimidyl Phenyl Sulfonate Moiety." Baghdad Science Journal 11, no. 2 (2014): 438–46. http://dx.doi.org/10.21123/bsj.2014.11.2.438-446.

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A series of Schiff bases linked to phthalimidyl phenyl sulfonate moiety have been synthesized via multistep synthesis. The first step involved reaction of phthalic anhydride with aniline producing N-phenyl phthalamic acid which was subsequently dehydrated to the corresponding N-phenyl phthalimide via treatment with acetic anhydride and anhydrous sodium acetate. The synthesized imide was treated with chlorosulfonic acid in the third step producing 4-(N-phthalimidyl) phenyl sulfonyl chloride which was introduced in reaction with 4-hydroxy acetophenone in the fourth step producing 4-[4-(N-phthali

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15

Barbarossa, Alexia, Alessia Catalano, Jessica Ceramella, et al. "Simple Thalidomide Analogs in Melanoma: Synthesis and Biological Activity." Applied Sciences 11, no. 13 (2021): 5823. http://dx.doi.org/10.3390/app11135823.

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Thalidomide is an old well-known drug that is still of clinical interest, despite its teratogenic activities, due to its antiangiogenic and immunomodulatory properties. Therefore, efforts to design safer and effective thalidomide analogs are continually ongoing. Research studies on thalidomide analogs have revealed that the phthalimide ring system is an essential pharmacophoric fragment; thus, many phthalimidic compounds have been synthesized and evaluated as anticancer drug candidates. In this study, a panel of selected in vitro assays, performed on a small series of phthalimide derivatives,

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16

Perveen, Shagufta, and Raha Orfali. "L-Proline-Catalyzed Synthesis of Phthalimide Derivatives and Evaluation of Their Antioxidant, Anti-Inflammatory, and Lipoxygenase Inhibition Activities." Journal of Chemistry 2018 (August 1, 2018): 1–6. http://dx.doi.org/10.1155/2018/5198325.

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A study was planned to synthesize the phthalimide derivatives as phthalimides have versatile biological activities. To synthesize the phthalimide derivatives, initially the reaction was optimized with various catalysts, and L-proline was found to be the best catalyst as it provided excellent yield. A series of phthalimide derivatives was synthesized by facile one-top reaction of phthalic acid with aryl amines under mild reaction conditions in the presence of L-proline as catalyst. Products were obtained in excellent yields and structurally characterized by 1H, 13C NMR, and mass spectral data.

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17

Miranda, Alexandre, Paula Marcos, José Ascenso, et al. "Conventional vs. Microwave- or Mechanically-Assisted Synthesis of Dihomooxacalix[4]arene Phthalimides: NMR, X-ray and Photophysical Analysis." Molecules 26, no. 6 (2021): 1503. http://dx.doi.org/10.3390/molecules26061503.

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Direct O-alkylation of p-tert-butyldihomooxacalix[4]arene (1) with N-(bromopropyl)- or N-(bromoethyl)phthalimides and K2CO3 in acetonitrile was conducted under conventional heating (reflux) and using microwave irradiation and ball milling methodologies. The reactions afforded mono- and mainly distal di-substituted derivatives in the cone conformation, in a total of eight compounds. They were isolated by column chromatography, and their conformations and the substitution patterns were established by NMR spectroscopy (1H, 13C, COSY and NOESY experiments). The X-ray structures of four dihomooxaca

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18

Ahanj, Negin, Mehdi Taghavi, and Ayyub Mojaddami. "Evaluation of Cytotoxicity and Molecular Docking Studies of Phthalimide and Naphthalimide Derivatives as Potential Anticancer Agents." Jundishapur Journal of Medical Sciences 20, no. 4 (2021): 366–75. http://dx.doi.org/10.32598/jsmj.20.4.2456.

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Background and Objectives Cancer is the second leading cause of death in the world after cardiovascular disease, so the aim of the present study was to investigate phthalimide and naphthalimide derivatives in order to develop anticancer compounds. Subjects and Methods In this study, the cytotoxic activity of six phthalimed and naphthalamide derivatives was evaluated using MTT method on three cancerous cell lines, including breast cancer (MCF-7), ovarian cancer (SKOV3) and lung cancer (A549) cell line. Molecular Docking studies were also performed to determine the binding energy and the compoun

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19

McClelland, Robert A., N. Esther Seaman, James M. Duff, and R. E. Branston. "Kinetics and equilibrium in the ammonolysis of substituted phthalimides." Canadian Journal of Chemistry 63, no. 1 (1985): 121–28. http://dx.doi.org/10.1139/v85-020.

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Kinetic studies are reported for the base hydrolysis to phthalamic acid anions (H) and ammonolysis to phthalamides (A) for seven phthalimides (P): 1, unsubstituted; 2, 4-NO2; 3, 4-Cl; 4, 4-t Bu; 5, 3-NO2; 6, 3-Me; 7, 3-Me3Si. The hydrolysis kinetics require two mechanisms, one which is first order in neutral imide and first order in hydroxide ion, and a second, which is important only in quite concentrated NaOH, which is first order in neutral phthalimide and second order in hydroxide ion. Ammonolysis kinetics for 1–5 revealed the rate law: Rate = kN [Unionized phthalimide] [NH3][OH−]. A mecha

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20

Orzeszko, A., R. Gralewska, B. J. Starościak, and Z. Kazimierczuk. "Synthesis and antimicrobial activity of new adamantane derivatives I." Acta Biochimica Polonica 47, no. 1 (2000): 87–94. http://dx.doi.org/10.18388/abp.2000_4065.

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A series of fourteen derivatives of adamantane was synthesised. The new compound 4-(adamant-1-ylmethoxycarbonyl)phthalanhydride obtained from 1-adamantane-methanol and trimellitic anhydride chloride appeared very useful for preparation of a number of N-substituted phthalimides. Antimicrobial activity of the newly obtained derivatives such as, for example, 4-(adamant-1-ylmethoxycarbonyl)-N-(5-carboxypentamethylene)p hthalimide or 4-(adamant-1-ylmethoxycarbonyl)-N-(L-alanyl)phthalimide was tested against Staphylococcus aureus, Bacillus sp., Micrococcus flavus and Enterococcus faecium. The minima

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21

Ahmad, Homsi, and Kasideh Amer. "Synthesis of some N-phthalimide derivatives and Evaluation their Biological Activity." Pharmaceutical and Chemical Journal 2, no. 3 (2015): 33–41. https://doi.org/10.5281/zenodo.13730096.

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In this research six of N-phthalimides of amino acids (<strong>IIIa-f)</strong> have been synthesized, as a first step, through cyclocondensation of o-phthalic acid with amino acids (glycine, L-alanine, L-valine, L-leucine, L-phenylalanine, L-aspartic) in the presence of glacial acetic acid in bath oil (170-180 <sup>o</sup>C), the results of this step were compared with the results of traditional method. In the second step, (<strong>IIIa-b) </strong>were refluxed with <em>o</em>-phenylene diamine (I<strong>Va</strong>) in the present of (HCl, 4N) for 2 h to give <em>N</em>-(1<em>H</em>-benzimi

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22

Assis, Shalom Pôrto de Oliveira, Moara Targino da Silva, Ronaldo Nascimento de Oliveira, and Vera Lúcia de Menezes Lima. "Synthesis and Anti-Inflammatory Activity of New Alkyl-Substituted Phthalimide 1H-1,2,3-Triazole Derivatives." Scientific World Journal 2012 (2012): 1–7. http://dx.doi.org/10.1100/2012/925925.

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Four new 1,2,3-triazole phthalimide derivatives with a potent anti-inflammatory activity have been synthesized in the good yields by the 1,3-dipolar cycloaddition reaction fromN-(azido-alkyl)phthalimides and terminal alkynes. The anti-inflammatory activity was determined by injecting carrageenan through the plantar tissue of the right hind paw of Swiss white mice to produce inflammation. All the compounds3a–cand5a–cexhibited an important anti-inflammatory activity; the best activity was found for the compounds3band5c, which showed to be able to decrease by 69% and 56.2% carrageenan-induced ede

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23

Cho, Dae Won, Patrick S. Mariano, and Ung Chan Yoon. "Direct and indirect single electron transfer (SET)-photochemical approaches for the preparation of novel phthalimide and naphthalimide-based lariat-type crown ethers." Beilstein Journal of Organic Chemistry 10 (February 27, 2014): 514–27. http://dx.doi.org/10.3762/bjoc.10.47.

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In this review, we describe direct and indirect photochemical approaches that have been developed for the preparation of phthalimide- and naphthalimide-based, lariat-type crown ethers. The direct route utilizes a strategy in which nitrogen-linked side chains containing polyethoxy-tethered phthalimides and naphthalimides, possessing terminal α-trialkylsilyl groups, are synthesized utilizing concise routes and UV-irradiation to form macrocyclic ring systems. In contrast, the indirect route developed for the synthesis of lariat-type crown ethers employs sequences in which SET-promoted macrocycliz

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24

Alves, Francinara S., Abraão P. Sousa, Alexandre Almeida-Júnior, et al. "Antimicrobial Investigation of Phthalimide and N-Phthaloylglycine Esters: Activity, Mechanism of Action, Synergism and Ecotoxicity." Life 15, no. 4 (2025): 518. https://doi.org/10.3390/life15040518.

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Motivated by the search for novel antimicrobials against opportunistic resistant pathogens and based on the reported antimicrobial activity of phthalimides, two series of phthalimide and N-phthaloylglycine esters were designed to investigate whether the addition of butyl and aryl groups enhances their antimicrobial properties. Thus, in vitro antimicrobial activity, antifungal mechanism of action, effect combined with Chloramphenicol, in silico/vitro toxicity, and a docking molecular were studied. Phthalimide and N-phthaloylglycine aryl esters were obtained in yields of 75–98%. Phthalimide aryl

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25

Lange, Peter, Annette Schier, Jürgen Riede, and Hubert Schmidbaur. "Gold(I) Complexes of Organic Nitrogen Compounds: Synthesis and Structures of (Phthalimido)(triphenylphosphine)gold(I) in Crystals C6H4(CO)2N(AuPPh3) and C6H4(CO)2N( AuPPh3) · CHCl3." Zeitschrift für Naturforschung B 49, no. 5 (1994): 642–46. http://dx.doi.org/10.1515/znb-1994-0512.

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[O(AuPPh3)3]+BF4- has been found to be a powerful aurating reagent for phthalimide, to give (phthalimido)(triphenylphosphine)gold(I) (1) in high yield. Two different crystal systems, with or without CHC13 molecules in the unit cell, have been obtained. In both cases the monoaurated diacylamido complex C6H4(CO)2N(AuPPh3) (1) is present as a monomer with linear two-coordinate gold atoms. The N-Au(I) bond lengths (2.028(4), 2.040(4) Å) are similar to those found in other monoaurated complexes of the type R]R2N(AuPPh3) with strongly electron-withdrawing organic substituents R1, R2. Crystal data:

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26

Watts, Jonathan, Jesús Jiménez-Barbero, Ana Poveda та T. Bruce Grindley. "Control of disaccharide conformation by π-stacking". Canadian Journal of Chemistry 81, № 5 (2003): 364–75. http://dx.doi.org/10.1139/v03-062.

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The conformations of a series of derivatives of the disaccharide α-L-fucopyranosyl-(1[Formula: see text]3)-2-acetamido-2-deoxy-D-glucopyranoside, part of the Lex determinant, were studied by molecular modelling using the MM3* forcefield and by 1H NMR spectroscopy. Unusually shielded O-benzyl protons were observed in the 1H NMR spectrum of phenyl 2,3,4-tri-O-benzyl-α-L-fucopyranosyl-(1[Formula: see text]3)-2-deoxy-2-phthalimido-1-thio-α-D-glucopyranoside and assigned to the 2-O-benzyl group. This observation was explained by a shift in the population of the conformational mixture present about

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27

Campos-Rodríguez, Carolina, José G. Trujillo-Ferrara, Ameyali Alvarez-Guerra, et al. "Neuropharmacological Screening of Chiral and Non-chiral Phthalimide- Containing Compounds in Mice: in vivo and in silico Experiments." Medicinal Chemistry 15, no. 1 (2019): 102–18. http://dx.doi.org/10.2174/1573406414666180525082038.

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Background: Thalidomide, the first synthesized phthalimide, has demonstrated sedative- hypnotic and antiepileptic effects on the central nervous system. N-substituted phthalimides have an interesting chemical structure that confers important biological properties. Objective: Non-chiral (ortho and para bis-isoindoline-1,3-dione, phthaloylglycine) and chiral phthalimides (N-substituted with aspartate or glutamate) were synthesized and the sedative, anxiolytic and anticonvulsant effects were tested. Method: Homology modeling and molecular docking were employed to predict recognition of the analog

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Sato, Yasuhiko, Hideo Nakai, Masao Wada, et al. "Photochemistry of the Phthalimide System, 37. Thiazacycloalkanols by Photocyclization ofS-SubstitutedN-(Thioalkyl)phthalimides." Liebigs Annalen der Chemie 1985, no. 6 (1985): 1099–118. http://dx.doi.org/10.1002/jlac.198519850602.

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29

Azad, Leila, and Khadijeh Yadollahzadeh. "Synthesis of new functionalized maleimides and phthalimides from maleimide, phthalimide, acetylenicesters, and phosphorus nucleophiles." Phosphorus, Sulfur, and Silicon and the Related Elements 197, no. 2 (2021): 144–50. http://dx.doi.org/10.1080/10426507.2021.2012678.

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30

Ribeiro da Silva, M. A. V., C. P. F. Santos, M. J. S. Monte, and C. A. D. Sousa. "Thermochemical studies of phthalimide and two N-alkylsubstituted phthalimides (ALKYL=ETHYL AND n-PROPYL)." Journal of Thermal Analysis and Calorimetry 83, no. 3 (2006): 533–39. http://dx.doi.org/10.1007/s10973-005-7448-3.

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Gondolova, Gulnar H. "SYNTHESIS AND STUDY OF Zn COMPLEXES WITH N'-ACYL-SALICYLHYDRAZIDES." IZVESTIYA VYSSHIKH UCHEBNYKH ZAVEDENII KHIMIYA KHIMICHESKAYA TEKHNOLOGIYA 62, no. 9 (2019): 27–32. http://dx.doi.org/10.6060/ivkkt.20196209.5902.

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Zn complexes with potentially tridentate (carbonyl and hydroxyl oxygen atoms of the salicylic fragment and nitrogen atom of the amide group) were synthesized by the ligand N'-phthalimido-salicylamide (H2L) and potentially heptadentate (carbonyl and hydroxyl oxygen atoms of the salicylic fragment, two nitrogen atoms of the hydrazide moiety and two oxygen atoms of the carbonyl and carboxyl groups of the maleic fragment) with the ligand N'-maleoal-salicylhydrazide (H4L) with 78% and 86% yield, respectively. The structural features of the N'-phthalimido-salicylamide (H2L) and N'-maleoyl-salicylhyd

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32

TAKECHI, HARUKO, MINORU MACHIDA, and YUICHI KANAOKA. "Intramolecular photoreactions of phthalimide-alkene systems. Oxetane formation of N-(.OMEGA.-indol-3-ylalkyl)phthalimides." CHEMICAL & PHARMACEUTICAL BULLETIN 36, no. 8 (1988): 2853–63. http://dx.doi.org/10.1248/cpb.36.2853.

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33

Sawczenko, Aleksandra, Barbara Miroslaw, Tadeusz Lis та Anna E. Koziol. "Direct synthesis of novel polymeric bimetallic phthalimide complex: poly{catena-(bis(μ3-phthalimido-N,O,O')-bis(μ2-phthalimido-N,O) -aqua-dipropanol-copper(II)disodium}". Pure and Applied Chemical Sciences 2 (2014): 73–86. http://dx.doi.org/10.12988/pacs.2014.447.

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34

Yang, Er-Qun, Jun-Tao Zhang, Xiao-Ping Cao, and Jin-Zhong Gu. "N-[2-(2-Hydroxyethoxy)phenethyl]phthalimide." Acta Crystallographica Section E Structure Reports Online 68, no. 6 (2012): o1636. http://dx.doi.org/10.1107/s1600536812018429.

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The title compound, C18H17NO4, was obtained accidentally through acid-catalysed aromatization of a phthalimide-substituted 2-(1-hydroxyethyl)cyclohex-2-enone. It exhibits an intramolecular O—H...Oc (c = carbonyl) hydrogen bond and forms a three-dimensional network structure via π–π stacking interactions between adjacent benzene rings (phthalimide-to-phenylene and phthalimide-to-phthalimide), with centroid–centroid distances of 3.8262 (6) and 3.6245 (5) Å.

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Kramer, Wolfgang H., Donya Razinoubakht, Gurjit Kaur, et al. "Awakening a Molecular Mummy: The Inter-and Intramolecular Photochemistry of Pyromellitic Diimides with Alkyl Carboxylates." Photochem 2, no. 3 (2022): 717–32. http://dx.doi.org/10.3390/photochem2030046.

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Pyromellitic acid diimides are not as chemically unreactive as conjecturable (and presupposed) from their numerous applications as electron acceptor units or electron carriers in molecular donor–acceptor dyads or triads. Similar to the corresponding phthalimides, electronically excited pyromellitic diimides oxidize alkyl carboxylates in aqueous solution via intermolecular electron transfer (PET) processes, which eventually results in radical–radical combination products, e.g., the benzylation product 6 from N,N′-dimethyl pyromellitic diimide 5. The analogous product 7 was formed with pivalic a

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Almeida, Marcel L., Maria C. V. A. Oliveira, Ivan R. Pitta, and Marina G. R. Pitta. "Advances in Synthesis and Medicinal Applications of Compounds Derived from Phthalimide." Current Organic Synthesis 17, no. 4 (2020): 252–70. http://dx.doi.org/10.2174/1570179417666200325124712.

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Phthalimide derivatives have been presenting several promising biological activities in the literature, such as anti-inflammatory, analgesic, antitumor, antimicrobial and anticonvulsant. The most well-known and studied phthalimide derivative (isoindoline-1,3-dione) is thalidomide: this compound initially presented important sedative effects, but it is now known that thalidomide has effectiveness against a wide variety of diseases, including inflammation and cancer. This review approaches some of the recent and efficient chemical synthesis pathways to obtain phthalimide analogues and also prese

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Sosei, Saito, Kana Yoshikawa, Noriko Tabata, et al. "TC11, a Novel Phthalimide Derivative, Directly Binds to NPM1 and Induced Apoptosis of High-Risk Myeloma Cells Via Centrosomal Disruption." Blood 120, no. 21 (2012): 1841. http://dx.doi.org/10.1182/blood.v120.21.1841.1841.

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Abstract Abstract 1841 PURPOSE: Despite recent advances in the treatment of multiple myeloma (MM), patients with high-risk chromosomal changes such as del13q, t(4;14) or del17p revealed significantly shorter survival. In addition, bone disease markedly reduces quality of life of the patients with MM. To overcome these problems, we have designed and screened synthetic phthalimides which significantly inhibited the growth of MM cell lines with high-risk chromosomal abnormalities. The purposes of this study are to explore novel drugs which possess anti-tumor activity against high-risk MM cells an

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Keita, Hamidou. "Adamantane-Functionalized Phthalimide Scaffold: Pathways to Supramolecular Interactions and Drug Discovery." Organics 2, no. 4 (2021): 388–94. http://dx.doi.org/10.3390/org2040022.

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Herein, the synthesis of a novel adamantanyl-functionalized phthalimide scaffold is demonstrated. The novel compound could be used as a precursor for various synthetic pathways owing to the generic use of adamantane substituents as the driving force for supramolecular interactions with macrocycles and N-substituted phthalimide derivatives as a core structure in numerous drugs. The adamantanyl-functionalized phthalimide scaffold contains bromide groups on the C4 and C5 positions of the benzene ring, effectively allowing further facile modifications of the scaffold. The structure was fully chara

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39

Listyani, Tiara Ajeng, and Rina Herowati. "Analisis Docking Molekuler Senyawa Derivat Phthalimide sebagai Inhibitor Non-Nukleosida HIV-1 Reverse Transcriptase." Jurnal Farmasi Indonesia 15, no. 2 (2018): 123–34. http://dx.doi.org/10.31001/jfi.v15i2.445.

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Senyawa derivat phthalimide dilaporkan sebagai kelas baru inhibitor nonnukleosida reverse transcriptase. Analisis docking molekuler senyawa derivat phthalimide terhadap enzim reverse transcriptase diperlukan untuk mengetahui afinitas dan pola interaksi antara senyawa di atas dengan enzim reverse transcriptase. Senyawa derivat phthalimide dioptimasi geometri menggunakan perangkat lunak VegaZZ selanjutnya dilakukan dengan cara preparasi target, preparasi ligan, validasi metode docking, dan analisis docking menggunakan PyRx-Python 0.8 - AutoDock Vina sehingga didapatkan interaksi ligan deng

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40

Jiang, Zhou, Jun-Dong Wang, Mei-Jin Lin, Nai-Sheng Chen, and Jin-Ling Huang. "2,2′-Methylenebis(isoindoline-1,3-dione)." Acta Crystallographica Section E Structure Reports Online 63, no. 11 (2007): o4385. http://dx.doi.org/10.1107/s1600536807050738.

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The title compound, C17H10N2O4, consists of two phthalimide units connected by a methylene bridge. The N—C—N bond angle is 110.64 (12)°. In the crystal structure, the dihedral angle between the two phthalimide units in one molecule is 88.96 (2)°. The crystal packing is stabilized by the π–π overlap of neighboring phthalimide units, with closest interplanar packing distances of 3.470 (1) and 3.626 (7) Å, and by weak C—H...O interactions.

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Lv, Wei, Huijiao Liu, Wen Wang, E. Yang, Hongyu Zhen, and Qidan Ling. "Synthesis of new conjugated polymers with coordinated praseodymium complexes for polymer memory devices." RSC Advances 7, no. 30 (2017): 18384–91. http://dx.doi.org/10.1039/c6ra28757c.

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A series of novel praseodymium(Pr)-coordinated polymers with phthalimide moieties were synthesized. The effects of the phthalimide moiety and neutral Pr complex on the polymer memory device performance were investigated.

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42

Veselý, Jan, Miroslav Ledvina, Jindřich Jindřich, Tomáš Trnka та David Šaman. "Synthesis of 2-Amino-2-deoxy-β-D-galactopyranosyl-(1→4)-2-amino-2-deoxy-β-D-galactopyranosides: Using Various 2-Deoxy-2-phthalimido-D-galactopyranosyl Donors and Acceptors". Collection of Czechoslovak Chemical Communications 69, № 10 (2004): 1914–38. http://dx.doi.org/10.1135/cccc20041914.

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A systematic study is presented of the efficiency of the most common glycosylation methods using standard 2-deoxy-2-phthalimidogalactopyranosyl donors ethyl 4-O-acetyl-3,6-di-O- benzyl-2-deoxy-2-phthalimido-1-thio-β-D-galactopyranoside (3a), 4-O-Acetyl-3,6-di-O-benzyl- 2-deoxy-2-phthalimido-β-D-galactopyranosyl bromide (4), 4-O-acetyl-3,6-di-O-benzyl-2-deoxy-2-phthalimido-β-D-galactopyranosyl fluoride (5b), O-(4-O-acetyl-3,6-di-O-benzyl-2-deoxy-2-phthalimido-β-D-galactopyranosyl) trichloroacetimidate (7) and ethyl 3,6-di-O-benzyl-2-deoxy-2-phthalimido-1-thio-β-D-galactopyranoside (8), pent-4-e

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43

Listyani, Tiara Ajeng, Fazlin Fauzi, Ariyanti Ariyanti, and Tatiana Siska Wardani. "In Silico Adme and Toxicity Studies of Derivative Phthalimide Compounds as Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitor." Proceedings of the International Conference on Nursing and Health Sciences 3, no. 1 (2022): 17–26. http://dx.doi.org/10.37287/picnhs.v3i1.1109.

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Phthalimide derivate compounds was reported as a new class of nonnucleoside reverse tranckriptase inhibitors. The aim of this research is to determine the prediction of absorption, distribution, metabolism, and excretion (ADME) as well as the toxicity test of phthalimide-derived compounds which have the best potential as HIV-1 reverse transcriptase enzyme inhibitors. This study used an in silico approach to predict oral bioavailability and toxicity. The prediction of the ADME in this study using SwissADME which is run online where thirty-three phthalimide derivate compounds have molecular weig

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Nilesh, S. Pawar, and M. Zalte Sanjay. "STUDIES AN ANTIMICROBIAL ACTIVITY OF VARIOUS N-SUBSTITUTED PHTHALIMIDES DERIVATIVES." Biolife 2, no. 4 (2022): 1027–33. https://doi.org/10.5281/zenodo.7228920.

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<strong>ABSTRACT</strong> Structural modification of various <em>N</em>-substituted phthalimides compounds through such simple, rapid and environment-friendly approach polymer support method has been taken to study the bioassay and their structure-activity relationships (SAR). Derivatization of phthalimide and <em>N</em>-hydroxy phthalimide exhibits good antibacterial efficacy and very less antifungal potency even though parent phthalimide moiety oriented compounds are potent fungicides. <strong>Key words:</strong> <em>N</em>-alkyl, <em>N</em>-acyl, <em>N</em>-alkyloxy, <em>N</em>-acyloxy, pht

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45

Szkatuła, Dominika, Edward Krzyżak, Paulina Stanowska, Magdalena Duda, and Benita Wiatrak. "A New N-Substituted 1H-Isoindole-1,3(2H)-Dione Derivative—Synthesis, Structure and Affinity for Cyclooxygenase Based on In Vitro Studies and Molecular Docking." International Journal of Molecular Sciences 22, no. 14 (2021): 7678. http://dx.doi.org/10.3390/ijms22147678.

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Isoindoline-1,3-dione derivatives constitute an important group of medicinal substances. In this study, nine new 1H-isoindole-1,3(2H)-dione derivatives and five potential pharmacophores were obtained in good yield (47.24–92.91%). The structure of the new imides was confirmed by the methods of elemental and spectral analysis: FT–IR, H NMR, and MS. Based on the obtained results of ESI–MS the probable path of the molecules decay and the hypothetical structure of the resulting pseudo-molecular ions have been proposed. The physicochemical properties of the new phthalimides were determined on the ba

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Khushal, Aneela, Umar Farooq, Sara Khan та ін. "Bioactivity-Guided Synthesis: In Silico and In Vitro Studies of β-Glucosidase Inhibitors to Cope with Hepatic Cytotoxicity". Molecules 28, № 18 (2023): 6548. http://dx.doi.org/10.3390/molecules28186548.

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The major cause of hyperglycemia can generally be attributed to β-glucosidase as per its involvement in non-alcoholic fatty liver disease. This clinical condition leads to liver carcinoma (HepG2 cancer). The phthalimides and phthalamic acid classes possess inhibitory potential against glucosidase, forming the basis for designing new phthalimide and phthalamic acid analogs to test their ability as potent inhibitors of β-glucosidase. The study also covers in silico (molecular docking and MD simulations) and in vitro (β-glucosidase and HepG2 cancer cell line assays) analyses. The phthalimide and

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Lian, Fei, Caocao Sun, Kun Xu, and Chengchu Zeng. "Electrochemical Dehydrogenative Imidation of N-Methyl-Substituted Benzylamines with Phthalimides for the Direct Synthesis of Phthalimide-Protected gem-Diamines." Organic Letters 21, no. 1 (2018): 156–59. http://dx.doi.org/10.1021/acs.orglett.8b03624.

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Banarouei, Nasimossadat, Asghar Davood, Hamed Shafaroodi, Ghazaleh Saeedi, and Abbas Shafiee. "N-arylmethylideneaminophthalimide: Design, Synthesis and Evaluation as Analgesic and Anti-inflammatory Agents." Mini-Reviews in Medicinal Chemistry 19, no. 8 (2019): 679–87. http://dx.doi.org/10.2174/1389557518666180424101009.

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Background and Objective: N-aryl derivatives of phthalimide and 4-nitro phthalimide have demonstrated cyclooxygenase inhibitory activity. Also, they possess excellent analgesic and antiinflammatory activity. In this work, a new series of N-arylmethylideneamino derivatives of phthalimide and 4-nitro phthalimide were designed and synthesized. Methods: The designed compounds were synthesized by condensation of the appropriate aldehyde and N-aminophthalimide in ethanol at room temperature at PH around 3. Their analgesic and antiinflammatory activity were evaluated by acetic acid-induced pain test

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Gera, Ankur, Chander Mohan, and Sandeep Arora. "Synthesis of Phthaloylglycyl Hydrazide Derivatives: Selective Protection of Phthalimide Group from Hydrazinolysis." Current Organic Synthesis 15, no. 6 (2018): 839–45. http://dx.doi.org/10.2174/1570179415666180601083256.

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Background: N-phthalimide amino acid hydrazide is a class of compounds that have the potential therapeutic use. In general, hydrazinolysis of N-substituted amino acid(s) ester removes the ester group and yields the corresponding hydrazide. However, in case if N-substitution group is phthalimide, phthalimide group is cleaved and not the ester group. The resulted compound, therefore, is amino acid ester rather than Nphthalimide amino acid hydrazide. The above class of compounds, because of susceptibility of phthalimide group to hydrazinolysis, has previously been synthesized by a lengthy three-s

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Nagel, N., H. Bock, and J. W. Bats. "Potassium Phthalimide." Acta Crystallographica Section C Crystal Structure Communications 52, no. 6 (1996): 1344–46. http://dx.doi.org/10.1107/s0108270196002387.

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