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1

National Association of Emergency Medical Technicians (U.S.). PHTLS: Trauma first response. St. Louis, MO: Elsevier/Mosby Jems, 2011.

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2

National Association of Emergency Medical Technicians (U.S.). Pre-Hospital Trauma Life Support Committee. and American College of Surgeons. Committee on Trauma., eds. PHTLS prehospital trauma life support. 6th ed. St. Louis, Mo: Mosby Jems/Elsevier, 2007.

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3

National Association of Emergency Medical Technicians (U.S.). Pre-Hospital Trauma Life Support Committee. PHTLS: Prehospital trauma life support. 7th ed. St. Louis, MO: Mosby Jems/Elsevier, 2011.

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4

McSwain, Norman E. PHTLS: Secours et soins préhospitaliers aux traumatisés. Paris: Elsevier, 2005.

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5

PHTLS - Digital Access. Jones & Bartlett Learning, LLC, 2019.

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6

PHTLS 9e: Print PHTLS Textbook with Digital Access to Course Manual eBook. Jones & Bartlett Learning, 2018.

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7

NAEMT. PHTLS Prehospital Trauma Life Support (Phtls: Basic & Advanced Prehospital Trauma Life Support). 6th ed. Mosby/JEMS, 2006.

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8

PHTLS - Prehospital Trauma Life Support. Jones & Bartlett Learning, LLC, 2014.

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9

Staff, National Association of Emergency Medical Technicians. PHTLS - Primera Respuesta Al Trauma. Jones & Bartlett Learning, LLC, 2013.

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10

Staff, National Association of Emergency Medical Technicians (NAEMT). PHTLS: Prehospital Trauma Life Support. Jones & Bartlett Learning, LLC, 2016.

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11

PHTLS: Prehospital Trauma Life Support. Jones & Bartlett Learning, 2010.

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12

National Association of Emergency Medical Technicians (U.S.). Pre-Hospital Trauma Life Support Committee. and American College of Surgeons. Committee on Trauma., eds. PHTLS: Prehospital trauma life support. 6th ed. Edinburgh: Elsevier Mosby, 2006.

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13

National Association of Emergency Medical Technicians (U.S.). Pre-Hospital Trauma Life Support Committee. and American College of Surgeons. Committee on Trauma., eds. PHTLS--Pre-Hospital Trauma Life Support. Akron, Ohio: Emergency Training, 1986.

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14

National Association of Emergency Medical Technicians (Us). Phtls 9e: Prehosp Trauma Life Support. Jones & Bartlett Learning, LLC, 2018.

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15

PHTLS: Prehospital Trauma Life Support, Military Edition. Jones & Bartlett Learning, LLC, 2019.

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16

NAEMT. PHTLS Prehospital Trauma Life Support: Military Version. 6th ed. Mosby/JEMS, 2006.

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17

PHTLS: Secours et Soins Prehospitaliers aux Traumatises. Jones & Bartlett Learning, LLC, 2016.

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18

NAEMT. PHTLS (Asistencia traumatologica en las urgencias prehospitalarias). 5th ed. Elsevier Espana, 2004.

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19

PHTLS : prehospital trauma life support - 7. ed. Mosby Jems/Elsevier, 2011.

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20

Teach Yourself Visually Phts. Visual, 2011.

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21

National Association of Emergency Medical Technicians (U.S.). Pre-Hospital Trauma Life Support Committee. and American College of Surgeons. Committee on Trauma., eds. PHTLS: Basic and advanced prehospital trauma life support. 5th ed. St. Louis, Mo: Mosby, 2003.

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22

American College of Surgeons (Other Contributor), ed. PHTLS: Basic and Advanced Prehospital Trauma Life Support. 5th ed. C.V. Mosby, 2003.

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23

Pac : Uk Phtls: Prehosp Trauma Lif Supp 9. Jones & Bartlett Learning, LLC, 2019.

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24

National Association of Emergency Medical Technicians (U.S.). Pre-Hospital Trauma Life Support Committee. and American College of Surgeons. Committee on Trauma., eds. PHTLS--basic and advanced prehospital trauma life support. 4th ed. St. Louis: Mosby, 1999.

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25

National Association of Emergency Medical Technicians (NAEMT). PHTLS Spanish : Soporte Vital de Trauma Prehospitalario: Octava Edicion. Jones & Bartlett Learning, 2015.

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26

LOZEAU. Pac: Italian Phtls 9 W/Op2 Ebk Crs Manl. Jones & Bartlett Learning, LLC, 2019.

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27

McSwain, Norman E. Phtls: Basic and Advanced : Pre-Hospital Trauma Life Support. 3rd ed. Mosby-Year Book, 1994.

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28

NAEMT. De Nederlandse uitgave van PHTLS: Prehospital Trauma Life Support. Bohn Stafleu van Loghum, 2020.

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29

National Association of Emergency Medical Technicians (U.S.) Pre-Hospital Trauma Life Support Committee. and American College of Surgeons. Committee on Trauma., eds. PHTLS--pre-hospital trauma life support: Basic and advanced. 3rd ed. St. Louis: Mosby, 1994.

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30

NAEMT. De Nederlandse uitgave van PHTLS: Prehospital Trauma Life Support. Bohn Stafleu van Loghum, 2017.

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31

PHTLS: Basic and advanced pre-hospital trauma life support. 3rd ed. St.Louis: Mosby-Year Book, 1994.

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32

PHTLS basic and advanced pre-hospital trauma life support. 2nd ed. Akron, OH: Emergency Training, 1990.

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33

Technicians, National Association of Emergency Medical. PHTLS Basic and Advanced Prehospital Trauma Life Support: Military Version. 5th ed. Mosby, 2004.

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34

Naemt. PHTLS: Basic and Advanced Prehospital Trauma Life Support Instructor Manual. Elsevier Health Sciences, 2002.

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35

NAEMT. PHTLS Basic and Advanced Prehospital Trauma Life Support Revised Reprint. 5th ed. Mosby, 2003.

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36

PHTLS: Prehospital Trauma Life Support for First Responders Course Manual. Jones & Bartlett Learning, LLC, 2019.

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37

National Association of Emergency Medical Technicians (NAEMT). PHTLS 8e : Prehospital Trauma Life Support: Includes EBook with Interactive Tools. Jones & Bartlett Learning, LLC, 2014.

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38

PHTLS : soporte vital basico y avanzado en el trauma prehospitalario - 6. ed. Elsevier, 2008.

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39

PHTLS : soporte vital básico y avanzado en el trauma prehospitalario - 7. ed. Mosby Jems/Elsevier, 2012.

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40

Menon, Deepa U. Autism and Intellectual Disabilities. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199937837.003.0053.

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Abstract:
PTEN (phosphatase and tensin homologue) on chromosome 10q23.3 is a tumor suppressor gene that encodes for a dual specificity phosphatase that regulates the phosphatidylinositol 3- kinase pathway and has an important role in brain development by affecting neuronal survival, neurite outgrowth, synaptic plasticity, and learning memory. Germline mutations of the PTEN gene have been implicated in a group of related tumor syndromes with autosomal dominant inheritance and variable expression and include the Cowden syndrome, Bannayan-Riley-Ruvalcaba syndrome, Proteus syndrome, and Juvenile Polyposis syndrome. These syndromes are collectively called the PTEN hamartoma tumor syndromes (PHTS) because they have a predisposition to tumors and hamartomas. PTEN germ line mutations have also been recently linked to autism and macrocephaly and the prevalence of PTEN mutation in children with autism spectrum disorder, and macrocephaly is reported to range from 1.1% to 16.7%.
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