Journal articles: 'Phttps'

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Battour, Mohamed, Muhammad Khalilur Rahman, and Md Sohel Rana. "The impact of PHTPS on trip quality, trip value, satisfaction and word of mouth." Journal of Islamic Marketing 11, no. 6 (November 11, 2019): 1517–38. http://dx.doi.org/10.1108/jima-03-2019-0058.

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Purpose The study aims to determine the impact of non-Muslim tourists’ perception of halal tourism products and services (PHTPS) on trip quality, trip value, satisfaction and word of mouth (WOM) towards halal tourism destination. Design/methodology/approach A total of 375 non-Muslim tourists were surveyed in Malaysia using partial least square technique. Findings The findings showed that PHTPS has a significant impact on all four dimensions. The strongest relationship was found between PHTPS and trip quality, followed by PHTPS–WOM, PHTPS–satisfaction and PHTPS–trip value. Originality/value This study provides new insights into the theory and practice of non-Muslim tourists’ PHTPS and WOM towards halal tourism destination. The findings are valuable to tourism operators, managers and marketers with the understanding and responsibility to develop halal tourism products and services from non-Muslim tourists’ insights.

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Tskitishvili, Ekaterine, Christel Pequeux, Carine Munaut, Renaud Viellevoye, Michelle Nisolle, Agnes Noël, and Jean-Michel Foidart. "Estrogen receptors and estetrol-dependent neuroprotective actions: a pilot study." Journal of Endocrinology 232, no. 1 (January 2017): 85–95. http://dx.doi.org/10.1530/joe-16-0434.

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Estetrol (E4) has strong antioxidative, neurogenic and angiogenic effects in neural system resulting in the attenuation of neonatal hypoxic–ischemic encephalopathy. We aimed to define the role of estrogen receptors in E4-dependent actions in neuronal cell cultures and prove the promyelinating effect of E4. In vitro the antioxidative and cell survival/proliferating effects of E4 on H2O2-induced oxidative stress in primary hippocampal cell cultures were studied using different combinations of specific inhibitors for ERα (MPP dihydrochloride), ERβ (PHTTP), GPR30 (G15) and palmytoilation (2-BR). LDH activity and cell survival assays were performed. In vivo the promyelinating role of different concentrations of E4 (1 mg/kg/day, 5 mg/kg/day, 10 mg/kg/day, 50 mg/kg/day) was investigated using the hypoxic–ischemic brain damage model in the 7-day-old immature rats before/after the induction of hypoxic–ischemic insult. Myelin basic protein (MBP) immunostaining was performed on brain coronal sections. Our results show that LDH activity is significantly upregulated in cell cultures where the E4’s effect was completely blocked by concomitant treatment either with ERα and ERβ inhibitors (MPP and PHTPP, respectively), or ERα and ERβ inhibitors combined with 2-BR. Cell survival is significantly downregulated in cell cultures where the effect of E4 was blocked by ERβ inhibitor (PHTTP) alone. The blockage of GRP30 receptor did affect neither LDH activity nor cell survival. MBP immunostaining is significantly upregulated in E4-pretreated groups at a concentration of 5 mg/kg/day and 50 mg/kg/day E4, whereas the MBP-positive area OD ratio is significantly increased in all the E4-treated groups. E4’s antioxidative actions mostly depend on ERα and ERβ, whereas neurogenesis and possibly promyelinating activities might be realized through ERβ.

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Angle, William. "PHTLS." Shock 11, no. 4 (April 1999): 302. http://dx.doi.org/10.1097/00024382-199904000-00015.

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Davies, L. G., D. C. Thompson, R. Gillett, and M. B. Smith. "Prescribing in the prehospital environment: a review of the pharmaceutical Module 501 on UK Military Exercise SAIF SAREEA 3. Can such analysis assist with the scaling of healthcare assets?" BMJ Military Health 166, no. 6 (April 27, 2020): 387–90. http://dx.doi.org/10.1136/bmjmilitary-2019-001363.

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IntroductionModule 501 provides core medications which are fundamental to the capability of a prehospital treatment team (PHTT). The quantities of each medication in the module inventory undergo regular review, but these do not correspond to a population at risk (PAR) figure or deployment length for which they intend to be used. This article proposes how the quantities of Module 501 drugs can be scaled for a given deployment, in this example using statistics taken from static PHTTs on Exercise Saif Sareea 3 (SS3).MethodsThe statistics were gathered using a custom-built search of electronic records from the Deployed Defence Medical Information Capability Programme in addition to written record-keeping, which were aligned to the weekly PAR at each PHTT location throughout their full operational capability periods. A quotient was then derived for each module item using a formula.ResultsAmong the 10 most commonly prescribed drugs were four analgesics and three antimicrobials. 42 of the 110 studied drugs were not prescribed during SS3.DiscussionThe data from SS3 reflect the typical scope of disease encountered in the deployed land setting. Employing these data, the use of a formula to estimate the drug quantities needed to sustain a Strike Armoured Infantry Brigade over a 28-day period is demonstrated.RecommendationsFurther study of Module 501 across varied deployment environments would be valuable in evolving this approach to medicinal scaling if proven effective for the warm desert climate. It could then be applied to other modules to further inform future Strike medical planning.LimitationsSeveral considerations when drawing deductions from the data are mentioned, including the inaccuracy of predictor variables taken from the EpiNATO-2 reports.ConclusionThe proposed formula provides an evidence-based framework for scaling drug quantities for a deployment planning. This may improve patient safety and confer logistical, storage and fiscal benefits.

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Ngara, Zakarias Seba. "FLUORESCENCE AND RED SHIFT OF THE PHOTOPHYSICAL PROPERTIES FROM PROTONATED SMALL MOLECULE." Jurnal Fisika : Fisika Sains dan Aplikasinya 5, no. 1 (April 15, 2020): 25–29. http://dx.doi.org/10.35508/fisa.v5i1.1514.

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In this work, the fluorescence (FL) and bathochromic of the photophysical properties from protonated small molecule in cast film state have been investigated. To realize these purposes, the material of 4’,4’’’’-(1,4-phenylene bis (2,2’:6’,2”-terpyridine) (Phtpy) as a small molecule and camphorsulfonic acid (CSA) as an acid for protonation was selected. For Phtpy, its maxima absorption is 300 nm and no FL color emission. After CSA solution was added in chlorofom solution of Phtpy, the absorption spectrum of protonated Phtpy is broaden to longer wavelength with two new peaks appear at around 350 and 370 nm. Upon direct excitation at wavelength of 300 nm, the range of FL spectrum of original and protonated Phtpy is from 320 to 580 nm and from 370 to 580 with their maxima FL intensities at 360 and 460 nm. Interestingly, protonated Phtpy emits blue FL color emission. In addition, energy gap of protonated Phtpy is smaller than that of pristine Phtpy. Finally, the FL and remarkable red shift of absorption and FL spectra of protonated Phtpy will pave the way to develop sensor and other photonic devices with high performances in the ultaviolet region.

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Benavides, Paola A., Tiago A. Matias, and Koiti Araki. "Unexpected lability of the [RuIII(phtpy)Cl3] complex." Dalton Transactions 46, no. 44 (2017): 15567–72. http://dx.doi.org/10.1039/c7dt03658b.

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[Ruⁱⁱⁱ(phtpy)Cl₃] complex is labile and releases terdentate phtpy ligand in solution leading to the formation of the homoleptic [Ruⁱⁱ(phtpy)₂] complex as main product instead of the desired [Ru(phtpy)(LL)Cl] complex upon reaction with bidentated LL ligands.

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Frenzel, Christoph, Fernando Somoza Jr., Steffen Blaurock, and Evamarie Hey-Hawkins. "Syntheses and solid-state structures of [{K(THF)2(PHTipp)K(THF)(µ-THF)(PHTipp)}x]2 and [Rb(THF)(PHTipp)]x (Tipp = 2,4,6-Pri3C6H2)." Journal of the Chemical Society, Dalton Transactions, no. 20 (2001): 3115. http://dx.doi.org/10.1039/b104576h.

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Deacon, Glen B., Peter C. Junk, and Aron Urbatsch. "Lanthanoid and Alkaline Earth Complexes Involving New Substituted Pyrazolates." Australian Journal of Chemistry 65, no. 7 (2012): 802. http://dx.doi.org/10.1071/ch12069.

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From the pyrazoles 3,5-di-(2′-furanyl)pyrazole (fu2pzH), 3-phenyl-5-(2′-thienyl)pyrazole (PhtpzH) and 3-(2′-furanyl)-5-(2′′-naphthyl)pyrazole (funappzH), a range of alkaline earth and lanthanoid pyrazolate complexes has been prepared by redox transmetallation/protolysis reactions between free metals, Hg(C6F5)2 and the pyrazoles, by reaction of I2‐activated metals with the pyrazoles, and in one case by a similar reaction of unactivated metal, in the donor solvents tetrahydrofuran (thf) and 1,2-dimethoxyethane (dme). Thus the divalent [Ca(Phtpz)2(thf)4], [Ba(Phtpz)2(thf)4] and [Ca(funappz)2(thf)4]·(thf) complexes, the heteroleptic [Yb(Phtpz)I(thf)4] and the trivalent [La(fu2pz)3(thf)3]·2thf complex have been prepared and structurally characterized, as well as the dme complexes [Yb(Phtpz)2(dme)2] and [Eu(Phtpz)3(dme)2]. Highlights include the first trans-[LnII(pz)I(thf)4] complex, a rare transoid [Ln(pz)2(dme)2] complex and a complex with both chelating and unidentate dme. In all cases, the Phtpz complexes exhibit pronounced positional disorder of the 2-thienyl and phenyl groups in the solid state, as do the two polymorphs of the parent pyrazole.

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Birks, Jonathan. "Prehospital trauma life support course (PHTLS)." BMJ 335, no. 7614 (August 11, 2007): gp59. http://dx.doi.org/10.1136/bmj.335.7614.sgp59.

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Woelfl, C. G., T. Guehring, A. Moghaddam, B. Gliwitzky, T. Schaedler, P. A. Gruetzner, M. Rieß, and C. B. Frank. "Der PHTLS-TEAM-Kurs – ein Pilotprojekt." Der Unfallchirurg 115, no. 3 (February 2, 2012): 243–50. http://dx.doi.org/10.1007/s00113-011-2124-5.

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Constable, Edwin C., Catherine E. Housecroft, Markéta Šmídková, and Jennifer A. Zampese. "Phosphonate-functionalized heteroleptic ruthenium(II) bis(2,2′:6′,2″-terpyridine) complexes." Canadian Journal of Chemistry 92, no. 8 (August 2014): 724–30. http://dx.doi.org/10.1139/cjc-2014-0065.

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The heteroleptic complexes [Ru(1)(4)][PF6]2, [Ru(2)(4)][PF6]2, [Ru(Phtpy)(4)][PF6]2, and [Ru(pytpy)(4)][PF6]2 (Phtpy = 4′-phenyl-2,2′:6′,2″-terpyridine, pytpy = 4′-(4-pyridyl)-2,2′:6′,2″-terpyridine, 1 and 2 = 4-methyl ester substituted derivatives of Phtpy and pytpy, 4 = ethyl 2,2′:6′,2″-terpyridine-4′-phosphonate) have been prepared. The single crystal structure of ligand 1 (1 = methyl 4-carboxy-4′-phenyl-2,2′:6′,2″-terpyridine) is reported. The introduction of the 4-methyl ester group causes a small red shift in the MLCT band of the ruthenium(II) complexes and a small shift to a more positive potential for the Ru2+/Ru3+ couple. The new complexes should serve as a useful starting point for development of ruthenium(II) dyes suited for sensitization of p-type semiconductors.

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Segerer, Ulrike, Joachim Sieler, and Evamarie Hey-Hawkins. "Insertions- und Substitutionsreaktion von Ameisensäuremethylester mit [Cp′2ZrCl(PHTipp)] - Molekülstruktur vonmeso-trans-[Cp′2ZrCl{OCH(PHTipp)2}] (Cp′ = η5-C5MeH4, Tipp = 2,4,6-Pri3C6H2)." Zeitschrift für anorganische und allgemeine Chemie 627, no. 6 (June 2001): 1259–63. http://dx.doi.org/10.1002/1521-3749(200106)627:6<1259::aid-zaac1259>3.0.co;2-s.

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Knigge, Verena. "PHTLS-Einteilung beim hypovolämischen Schock wirklich zuverlässig?" retten! 3, no. 01 (February 25, 2014): 66. http://dx.doi.org/10.1055/s-0034-1370402.

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Wölfl, C. G., B. Bouillon, C. K. Lackner, A. Wentzensen, B. Gliwitzky, B. Groß, J. Brokmann, and T. Hauer. "Prehospital Trauma Life Support® (PHTLS®)." Der Unfallchirurg 111, no. 9 (June 28, 2008): 688–94. http://dx.doi.org/10.1007/s00113-008-1466-0.

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Leal, Laura Andrian, Silvia Helena Henriques Camelo, Fernanda Ludmilla Rossi Rocha, Thamiris Cavazzani Vegro, and Fabiana Cristina Santos. "Health promotion of nursing staff in hospital environments." Revista da Rede de Enfermagem do Nordeste 16, no. 5 (November 10, 2015): 762. http://dx.doi.org/10.15253/2175-6783.2015000500019.

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Objective: To analyze the scientific evidence of the strategies adopted by hospitals aimed at promoting the health of nursing workers. Methods: integrative review with data collected in electronic databases: Medline, Lilacs, Scielo, BDENF, Scopus and CINAHL, with the descriptors: Strategies; hospitals; Nursing and Health Promotion Team. Results: there were 18 articles selected and the analysis allowed to find organizational strategies to promote the health of nursing workers as phttp://www.revistarene.ufc.br/revista/index.php/revista/article/view/2074/pdfrevention of biological risks, the use of personal protective equipment, among others. Conclusion: strategies for health promotion are possible as necessary and they should be reconsidered by managers and professionals working in hospitals in order to promote the quality of working life.

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Iyoku, Yoshitake, Masa-aki Kakimoto, and Yoshio Imai. "The preparation of new poly(phenylsilsesquioxane)-polyimide hybrid films by the sol-gel process and their properties." High Performance Polymers 6, no. 1 (February 1994): 53–62. http://dx.doi.org/10.1088/0954-0083/6/1/006.

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The preparation of poly(phenylsilsesquioxane)-polyimide hybrid films was successfully performed with phenyltriethoxysilane (PhTES) and the polyamic acid (polyimide precursor) prepared from 4.4'-oxydianiline (ODA) and pyromellitic dianhydride (PMDA). During the heating process at 300 C, the imidization of the polyamic acid and the sol-gel reaction, hydrolysis and condensation of PhTES, proceeded simultaneously. The IR spectrum and the t3C-NMR and 29Si-NmR spectra showed that the sol-gel reaction of PhTES proceeded in the polymer matrix with high conversion. The hybrid films with a silsesquioxane content up to 75 wt% were obtained as the self-standing form. The hybrid films having a silsesquioxane content of 45 wt% were yellow and transparent, and those having more silicone content were yellow and translucent. The therma] properties of the hybrid films were improved to some extent by the introduction of the silsesquioxane component into the polyimide matrix. With respect to the tensile properties. the tensile strength remained around 85 MPa up to a silicone content of 45 wt%. This value was twice that of the hybrid films based on methyltriethoxysilane. The tensile modulus decreased with increasing silsesquioxane content.

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Jonker, L. A., C. A. Lebbink, M. C. J. Jongmans, R. A. J. Nievelstein, J. H. M. Merks, E. J. M. Nieveen van Dijkum, T. P. Links, N. Hoogerbrugge, A. S. P. van Trotsenburg, and H. M. van Santen. "Recommendations on Surveillance for Differentiated Thyroid Carcinoma in Children with PTEN Hamartoma Tumor Syndrome." European Thyroid Journal 9, no. 5 (2020): 234–42. http://dx.doi.org/10.1159/000508872.

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Background: PTEN hamartoma tumor syndrome (PHTS) represents a group of syndromes caused by a mutation in the PTEN gene. Children with a germline PTEN mutation have an increased risk of developing differentiated thyroid carcinoma (DTC). Several guidelines have focused on thyroid surveillance in these children, but studies substantiating these recommendations are lacking. Objective: The present study intends to provide the available evidence for a thyroid carcinoma surveillance program in children with PHTS. Methods: An extensive literature search was performed to identify all studies on DTC in pediatric PHTS patients. Two pediatric cases are presented to illustrate the pros and cons of thyroid carcinoma surveillance. Recommendations for other patient groups at risk for DTC were evaluated. Consensus within the study team on recommendations for children with PHTS was reached by balancing the incidence and behavior of DTC with the pros and cons of thyroid surveillance, and the different surveillance methods. Results: In 5 cohort studies the incidence of DTC in childhood ranged from 4 to 12%. In total 57 cases of DTC and/or benign nodular disease in pediatric PHTS patients were identified, of which 27 had proven DTC, with a median age of 12 years (range 4–17). Follicular thyroid carcinoma (FTC) was diagnosed in 52% of the pediatric DTC patients. No evidence was found for a different clinical behavior of DTC in PHTS patients compared to sporadic DTC. Conclusions: Children with PHTS are at increased risk for developing DTC, with 4 years being the youngest age reported at presentation and FTC being overrepresented. DTC in pediatric PHTS patients does not seem to be more aggressive than sporadic DTC. Recommendations: Surveillance for DTC in pediatric PHTS patients seems justified, as early diagnosis may decrease morbidity. Consensus within the study team was reached to recommend surveillance from the age of 10 years onwards, since at that age the incidence of DTC seems to reach 5%. Surveillance for DTC should consist of yearly neck palpation and triennial thyroid ultrasound. Surveillance in children with PHTS should be performed in a center of excellence for pediatric thyroid disease or PHTS.

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Kuniyoshi, Minoru, Masahide Takahashi, Yomei Tokuda, and Toshinobu Yoko. "Hydrolysis and polycondensation of acid-catalyzed Phenyltriethoxysilane (PhTES)." Journal of Sol-Gel Science and Technology 39, no. 2 (June 27, 2006): 175–83. http://dx.doi.org/10.1007/s10971-006-7465-0.

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Wang, Peng, Glenn P. A. Yap, and Charles G. Riordan. "Iron(II)–alkoxide and –aryloxide complexes of a tris(thioether)borate ligand: synthesis, molecular structures, and implications on the origin of instability of their iron(II)–catecholate counterpart." Acta Crystallographica Section C Structural Chemistry 77, no. 9 (August 23, 2021): 544–50. http://dx.doi.org/10.1107/s2053229621008500.

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The phenyltris[(tert-butylthio)methyl]borate ligand, [PhTt tBu], has been studied extensively as a platform for coordination, organometallic, and bioinorganic chemistry, especially with 3d metals. While [PhTt tBu]Co(3,5-DBCatH) (3,5-DBCatH is 3,5-di-tert-butylcatecholate), a CoII–monoanionic catecholate complex, was successfully isolated to model the active site of cobalt(II)-substituted homoprotocatechuate 2,3-dioxygenase (Co-HPCD) [Wang et al. (2019). Inorg. Chim. Acta, 488, 49–55], its iron(II) counterpart, [PhTt tBu]Fe(3,5-DBCatH), was not accessible via similar synthetic routes. Switching the nucleophile from catecholate to alkoxide or aryloxide, however, led to the successful isolation of three highly air-sensitive FeII–alkoxide and –aryloxide complexes, namely, (triphenylmethoxo){tris[(tert-butylsulfanyl)methyl]phenylborato-κ3 S,S′,S′′}iron(II), [Fe(C21H38BS3)(C19H15O)], (2), (2,6-dimethylphenolato){tris[(tert-butylsulfanyl)methyl]phenylborato-κ3 S,S′,S′′}iron(II), [Fe(C21H38BS3)(C8H9O)], (3), and bis{μ-tris[(tert-butylsulfanyl)methyl]phenylborato-κ3 S,S′:S′′}bis[(phenolato-κO)iron(II)] toluene disolvate, [Fe2(C21H38BS3)2(C6H5O)2]·2C7H8, (4). In the solid state, compounds (2) and (3) are monomeric, with [PhTt tBu] acting as a tridentate ligand. In contrast, compound (4) crystallizes as a dimeric complex, wherein each [PhTt tBu] ligand binds to an iron centre with two thioethers and binds to the other iron centre with the third thioether. The molecular structures of (2)–(4) demonstrate a diversity in the binding modes of [PhTt tBu] and highlight its potential use for assembling multinuclear complexes. In addition, the successful isolation of (2)–(4), as well as the structural information of a [PhTt tBu] modification product, namely, bis{μ-tris[(tert-butylsulfanyl)methyl](2-oxidophenolato)borato-κO,O′,S,S′:O′}dicobalt(II), [Co2(C21H37BO2S3)2], (5), obtained from the reaction of [PhTt tBu]CoCl with potassium monoanionic catecholate, shed light on the origin of the instability of [PhTt tBu]Fe(3,5-DBCatH).

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Shokouhi Mehr, Hamideh, Natalie C. Romano, Rashid Altamimi, Jody M. Modarelli, and David A. Modarelli. "Core substituted naphthalene diimide – metallo bisterpyridine supramolecular polymers: synthesis, photophysics and morphology." Dalton Transactions 44, no. 7 (2015): 3176–84. http://dx.doi.org/10.1039/c4dt02719a.

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A series of metallo Ru(ii), Fe(ii), Co(ii) bisterpyridine polymers were prepared with core-substituted naphthalene diimide (NDI) groups inserted between two 4′-phenyl-2,2:6′,2′′-terpyridine (phtpy) groups.

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Zhang, Lin, Yu Xiao, Ying Gao, Na Zhao, Yajuan An, Wenxiang Yang, Qingfang Meng, Hongfei Yan, and Daqun Liu. "Race and Virulence Analysis of Puccinia triticina in China During 2011 to 2013." Plant Disease 104, no. 8 (August 2020): 2095–101. http://dx.doi.org/10.1094/pdis-01-20-0047-re.

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Wheat leaf rust, caused by Puccinia triticina, is a common fungal disease of wheat in China. In order to identify races and determine the individual virulence of isolates in different wheat-growing regions in China, leaf rust samples collected from 18 provinces in 2011 to 2013 were tested on 37 Thatcher near-isogenic lines each carrying a different single leaf rust resistance gene. A total of 158 races were identified. Races THTT (19.5%), THTS (16.9%), PHTT (7.7%), THJS (5.0%), THJT (4.2%), and PHTS (4.0%) were the most predominant races in 2011 to 2013. All of these races were avirulent to resistance genes Lr9 and Lr24. The two most frequent races, THTT and THTS, were widely distributed. The frequencies of the isolates with virulence to Lr1, Lr2c, Lr3, Lr16, Lr26, Lr17, LrB, Lr10, Lr14a, Lr3bg, Lr14b, Lr33, Lr37, and Lr50 exceeded 90%. Frequencies of virulence to Lr2a, Lr3ka, Lr11, Lr30, Lr2b, and Lr32 exceeded 70% but were less than 90%. Frequencies of virulence to Lr18, Lr21, Lr15, Lr23, Lr33+34, Lr36, Lr39, and Lr44 were below 70%, whereas the frequency of virulence to Lr25 was less than 1%. All isolates were avirulent to Lr9, Lr19, Lr24, Lr28, Lr42, Lr29, Lr38, and Lr47. The identified races and individual virulence frequencies provide a basis for selection of effective leaf rust resistance genes for use in breeding programs and can also provide information for the study of race evolution of P. triticina.

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Byrd, Victoria, Ted Getz, Roshan Padmanabhan, Hans Arora, and Charis Eng. "The microbiome in PTEN hamartoma tumor syndrome." Endocrine-Related Cancer 25, no. 3 (March 2018): 233–43. http://dx.doi.org/10.1530/erc-17-0442.

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Germline PTEN mutations defining PTEN hamartoma tumor syndrome (PHTS) confer heritable predisposition to breast, endometrial, thyroid and other cancers with known age-related risks, but it remains impossible to predict if any individual will develop cancer. In the general population, gut microbial dysbiosis has been linked to cancer, yet is unclear whether these are associated in PHTS patients. In this pilot study, we aimed to characterize microbial composition of stool, urine, and oral wash from 32 PTEN mutation-positive individuals using 16S rRNA gene sequencing. PCoA revealed clustering of the fecal microbiome by cancer history (P = 0.03, R 2 = 0.04). Fecal samples from PHTS cancer patients had relatively more abundant operational taxonomic units (OTUs) from family Rikenellaceae and unclassified members of Clostridia compared to those from non-cancer patients, whereas families Peptostreptococcaceae, Enterobacteriaceae, and Bifidobacteriaceae represented relatively more abundant OTUs among fecal samples from PHTS non-cancer patients. Functional metagenomic prediction revealed enrichment of the folate biosynthesis, genetic information processing and cell growth and death pathways among fecal samples from PHTS cancer patients compared to non-cancer patients. We found no major shifts in overall diversity and no clustering by cancer history among oral wash or urine samples. Our observations suggest the utility of an expanded study to interrogate gut dysbiosis as a potential cancer risk modifier in PHTS patients.

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Ciurluini, Cristiano, Fabio Giannetti, Alessandro Del Nevo, and Gianfranco Caruso. "Study of the EU-DEMO WCLL Breeding Blanket Primary Cooling Circuits Thermal-Hydraulic Performances during Transients Belonging to LOFA Category." Energies 14, no. 6 (March 11, 2021): 1541. http://dx.doi.org/10.3390/en14061541.

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The Breeding Blanket (BB) is one of the key components of the European Demonstration (EU-DEMO) fusion reactor. Its main subsystems, the Breeder Zone (BZ) and the First Wall (FW), are cooled by two independent cooling circuits, called Primary Heat Transfer Systems (PHTS). Evaluating the BB PHTS performances in anticipated transient and accident conditions is a relevant issue for the design of these cooling systems. Within the framework of the EUROfusion Work Package Breeding Blanket, it was performed a thermal-hydraulic analysis of the PHTS during transient conditions belonging to the category of “Decrease in Coolant System Flow Rate”, by using Reactor Excursion Leak Analysis Program (RELAP5) Mod3.3. The BB, the PHTS circuits, the BZ Once Through Steam Generators and the FW Heat Exchangers were included in the study. Selected transients consist in partial and complete Loss of Flow Accident (LOFA) involving either the BZ or the FW PHTS Main Coolant Pumps (MCPs). The influence of the loss of off-site power, combined with the accident occurrence, was also investigated. The transient analysis was performed with the aim of design improvement. The current practice of a standard Pressurized Water Reactor (PWR) was adopted to propose and study actuation logics related to each accidental scenario. The appropriateness of the current PHTS design was demonstrated by simulation outcomes.

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Echeverría, Jesús C., Ignacio Calleja, Paula Moriones, and Julián J. Garrido. "Fiber optic sensors based on hybrid phenyl-silica xerogel films to detect n-hexane: determination of the isosteric enthalpy of adsorption." Beilstein Journal of Nanotechnology 8 (February 21, 2017): 475–84. http://dx.doi.org/10.3762/bjnano.8.51.

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We investigated the response of three fiber optic sensing elements prepared at pH 10 from phenyltriethoxysilane (PhTEOS) and tetraethylsilane (TEOS) mixtures with 30, 40, and 50% PhTEOS in the silicon precursor mixture. The sensing elements are referred to as Ph30, Ph40 and Ph50, respectively. The films were synthesized by the sol–gel method and affixed to the end of optical fibers by the dip-coating technique. Fourier transform infrared spectroscopy, N2 adsorption–desorption at 77 K and X-ray diffraction analysis were used to characterize the xerogels. At a given pressure of n-hexane, the response of each sensing element decreased with temperature, indicating an exothermic process that confirmed the role of adsorption in the overall performance of the sensing elements. The isosteric adsorption enthalpies were obtained from the calibration curves at different temperatures. The magnitude of the isosteric enthalpy of n-hexane increased with the relative response and reached a plateau that stabilized at approximately −31 kJ mol−1 for Ph40 and Ph50 and at approximately −37 kJ mol−1 for Ph30. This indicates that the adsorbate–adsorbent interaction was dominant at lower relative pressure and condensation of the adsorbate on the mesopores was dominant at higher relative pressure.

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Shen, Weidan, Kangning Xiong, Yang Gao, Mingying Quan, Haijun Peng, Ting Yang, Linfeng He, and Kunshan Bao. "Distribution of Potential Harmful Trace Elements and Potential Ecological Risk in the Jiulongchi Wetland of Fanjing Mountain, Southwest China." International Journal of Environmental Research and Public Health 17, no. 5 (March 6, 2020): 1731. http://dx.doi.org/10.3390/ijerph17051731.

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In order to understand the distribution and ecological risk of potential harmful trace elements (PHTEs) in the high altitude areas of the Fanjing Mountain World Natural Heritage Property, 30 surface samples including soil and plants were collected in April, 2019 in the Jiulongchi wetland which lies in the saddle between the New Jinding Peak of Fanjing Mountain and Fenghuang Peak. The contents of 23 major and trace elements were determined, and the pollution characteristics and potential ecological risk of 11 PHTEs (Mn, V, Zn, Cr, Co, Ni, Cu, As, Cd, Sb and Pb) were discussed. The element contents showed significant differences in plant and soil samples. Enrichment factor and single-factor pollution index demonstrated that Mn, Zn, Co, As and Cd in the soil were in a clean state. The potential ecological risk index and pollution load index indicated an overall good ecological condition of Jiulongchi wetland, with a weak pollution degree. Comparisons of relevant studies showed the anthropogenic activities have considerable impacts on the pollution status of PHTEs with significant spatial differences in Fanjing Mountain. Multivariate statistical analysis proved that Pb and Sb were main pollutants of the soil in the Jiulongchi wetland, and the mining and smelting of minerals such as mercury, manganese and lead-zinc ore in the adjacent areas could be the main pollution sources through atmospheric deposition. This study could provide targeted strategies for the environmental protection and management of the Property and give scientific evidence for the pollution prevention in southwest China.

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Harper, Peter Nicholas, N. Taylor, P. Royal, and MB Smith. "Role of the pre-hospital treatment team on the UK military exercise SAIF SAREEA 3." BMJ Military Health 166, no. 6 (April 28, 2020): 421–24. http://dx.doi.org/10.1136/bmjmilitary-2019-001366.

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The prehospital treatment team (PHTT) involves a small team working under the clinical supervision of a clinical lead. The clinical lead can be a general duties medical officer (Post Foundation Years Doctor), military nurse practitioner or more senior clinician. The team is mounted in vehicles appropriate to the environment they expect to operate in. A PHTT is closely located to the front line reducing transportation timelines from the point of wounding to more definitive care. The PHTT can provide medical support on the move or when time is available; a more permanent fully erected treatment facility can be established. Either configuration can provide both trauma and primary care. The size of the team allows for multiple trauma subteams enabling care to casualties that arrive simultaneously. The PHTT can move independently which could leave the team vulnerable as there is no integral force protection within the current structure. In such a small team, the right balance of medical and soldiering skills among team members is essential to success. Exercise SAIF SAREEA 3 represented a large-scale battlegroup exercise to the Middle East in the austere desert of Oman. This provided an ideal environment for employing the PHTT concept is a large deployed force undertaking dynamic activity.

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Liu, Lang, David Elwood, Derek Martin, and Rick Chalaturnyk. "Determination of permeability of overconsolidated clay from pressuremeter pressure hold tests." Canadian Geotechnical Journal 55, no. 4 (April 2018): 514–27. http://dx.doi.org/10.1139/cgj-2017-0279.

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A method was developed to interpret the horizontal permeability (kh) from pressuremeter pressure hold tests (PHTs) of approximately 3 min duration. The method relies on a regression analysis of the numerical analysis simulating the consolidation of clay under a constant pressure boundary during undrained expansion. The method was applied to a series of PHTs performed in deep clay formations in the Seattle area. The interpreted permeabilities are thought to be more representative of in situ conditions than those determined by laboratory testing by virtue of reduced disturbance during sample recovery and preparation. Results could be improved with a further exclusion of the creep effect on PHTs.

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Smpokou, Patroula, Victor L. Fox, and Wen-Hann Tan. "PTEN hamartoma tumour syndrome: early tumour development in children." Archives of Disease in Childhood 100, no. 1 (August 11, 2014): 34–37. http://dx.doi.org/10.1136/archdischild-2014-305997.

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ObjectiveThe aim of this study was to report the earliest age of diagnosis of common clinical findings in children with PTEN hamartoma tumour syndrome (PHTS).DesignMedical records of children with PHTS were reviewed; data included growth measurements, presence or absence of specific clinical manifestations and tumours, and documented ages of diagnosis.SettingChildren with PHTS evaluated at Boston Children's Hospital from 1996 to 2011.PatientsThe cohort included 34 children diagnosed with PHTS via genetic testing, under the age of 21 years. Of these, 23 were male and 11 female. The mean age at their last documented clinical evaluation was 13.6 years. The mean follow-up time was 7.5 years.ResultsMacrocephaly and developmental/intellectual disability were consistent findings. Pigmented penile macules were noted in all males examined for this finding. Thyroid nodules, found in half the children screened with ultrasound, were diagnosed as early as at 5 years of age. Thyroid carcinoma, identified in 12% of the children in this cohort, was diagnosed as early as at 7 years of age. Other tumours included renal cell carcinoma diagnosed at 11 years of age and granulosa cell tumour of the ovary and colonic ganglioneuroma, each diagnosed at 16 years of age.ConclusionsSpecific clinical findings and tumours are characteristic in children with PHTS. Tumour development occurs in young children with this condition, which necessitates early surveillance, especially of the thyroid.

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Zhou, Yang, Xupeng Lou, Jialin Zhao, Zhe Chen, Fuhuan Le, and Yousheng Fang. "Preparation of Absorbable Suture Biomaterial Formed by Glycolide/Lactide and Its Application in the Congenital Thumb Deformity Surgery." Science of Advanced Materials 13, no. 4 (April 1, 2021): 683–93. http://dx.doi.org/10.1166/sam.2021.3961.

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Conducting polymers (CPs) can regulate cell behavior and promote the regeneration of damaged tissues, which are widely applied in tissue engineering. In this study, poly(3-hexylthiophene) (PHTP) was first obtained by the catalyst + transfer poly-condensation method, and then, it was mixed with poly(lactide-co-glycolide) (PLGA) to obtain a composite material with superconductivity (PHTP/PLGA). Besides, ferric chloride (FeCl3) was selected as the dopant, and the doping time was changed, so as to obtain 5 PHTP/PLGA materials with different conductivity (10-7 S/cm, 10-6 S/cm, 10-5 S/cm, 10-4 S/cm, and 10-3 S/cm). While PHTP/PLGA was physically characterized, the cell proliferation ability and blood compatibility of this series of materials were further analyzed, and the materials were made into medical sutures for the treatment of congenital thumb deformities. In the experiment, the surface morphology, hydrophilicity, and hydrophobicity of materials with different conductivity would not affect the difference in cell behavior. Using mouse embryonic osteoblasts (MC3T3-E1) as the research objects, increasing PHTP/PLGA conductivity could promote MC3T3-E1 alkaline phosphatase activity cell mineralization, and collagen type I expression. PHTP/PLGA series materials had a low hemolysis rate and were not easily affected by platelet adhesion and activation, meaning that they would not cause coagulation. The material was applied in the direct suture method of hammer deformity, and the results showed that the patient’s deformed thumb had a knot reaction and local skin edge necrosis. After dressing change, it gradually improved. Moreover, the excellent and good rate of deformed thumb based on this material was higher than that of wire extraction method and Kirschner wire fixation method (P < 0.05).

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McLean, Allen. "mHealth Apps as Effective Persuasive Health Technology: Contextualizing the “Necessary” Functionalities." JMIR Nursing 3, no. 1 (July 15, 2020): e19302. http://dx.doi.org/10.2196/19302.

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Persuasive health technology (PHT) is any technology purposely designed to influence, reinforce, change, or shape health-related attitudes or behaviors. Behavioral interventions can be developed for the purpose of maintaining or improving a person’s health status. Delivering behavioral interventions via PHTs is a promising approach for encouraging healthy behaviors among individuals and populations. Important attributes of all PHTs include their functionalities. A functionality refers to any useful features, functions, capabilities, or technologies associated with computer hardware or software. Creating effective PHTs requires a deliberate selection of appropriate functionalities for supporting specific behavioral interventions. The number and types of functionalities necessary to create an effective PHT will be specific to the context of each project, influenced by project objectives, stakeholder goals, behavioral interventions, and a variety of real-world constraints. Selecting appropriate functionalities can be challenging. Fortunately, there are frameworks and models developed specifically for guiding the design of PHTs. The Persuasive Systems Design model describes 4 categories, and 28 design principles for creating effective persuasive interventions. These same design principles could also be useful for guiding the selection of appropriate functionalities.

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Cannarella, Rossella, Beniamino Scilletta, Roberto Scilletta, Gaetano Magro, and Aldo E. Calogero. "Resolution of primary hyperparathyroidism following surgical removal of cervical thymus." Case Reports in Internal Medicine 4, no. 2 (February 8, 2017): 5. http://dx.doi.org/10.5430/crim.v4n2p5.

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Recent research has emphasized the capacity of thymus cells of producing parathyroid hormone (PTH) if adequately stimulated, and have investigated the role of the so-called “thymic PTH”, produced by the medullary thymic epithelial cells (m-TECs). To the best of our knowledge, only a single case of well-documented PTH secretion from a thymoma causing primary hyperparathyroidism (PHTP) has been reported in the literature so far. We report here the case of a female patient with PHTP who underwent neck exploration for a suspected parathyroid adenoma. After surgery, a normalization of serum PTH concentration was observed, but the histological examination of the surgically excised mass revealed exclusively normal thymus tissue. The present case provides additional evidence of PHTP caused by an ectopic thymus.

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Plamper, Michaela, Bettina Gohlke, Felix Schreiner, and Joachim Woelfle. "Phenotype-Driven Diagnostic of PTEN Hamartoma Tumor Syndrome: Macrocephaly, But Neither Height nor Weight Development, Is the Important Trait in Children." Cancers 11, no. 7 (July 11, 2019): 975. http://dx.doi.org/10.3390/cancers11070975.

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PTEN hamartoma tumor syndrome (PHTS) encompasses different syndromic disorders which are associated with autosomal-dominant mutations of the tumor suppressor gene PTEN. Patients are at high risk to develop benign and malignant tumors. Macrocephaly is a diagnostic feature, but there is a paucity of data on auxological development during childhood. Growth charts for height, weight and head circumference for PHTS do not exist yet. In this study, patient data for height, weight and head circumferences (HC) were collected from repeated medical exams or prevention check-up visits starting at birth. Growth charts were generated and compared to German reference data. Standard deviation scores (SDS) of HC, height and body mass index (BMI) were calculated. We included 23 pediatric patients (8 female, 15 male) with molecular proven PTEN gene mutation. Most male patients already demonstrated macrocephaly at birth (73%), whereas only one female patient had documented congenital macrocephaly. By the age of two years all patients exhibited a head circumference above the 97th percentile. Stratified for different age groups the median HC-SDSs were between +3.3 and +5.5 in male patients and between +2.9 and +4.1 in female patients. Height, weight and BMI measurements for both sexes were mostly within the normal range. We conclude that macrocephaly, but not height, weight or BMI, is useful in the identification of PHTS patients. The increased HC in PHTS patients develops early in life and is more pronounced in males than in females, which might explain the finding of a higher percentage of male PHTS patients diagnosed during childhood.

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Geszke-Moritz, Małgorzata. "Modeling of boldine adsorption onto PHTS mesoporous silica Modelowanie procesu adsorpcji boldyny na mezoporowatej krzemionce PHTS." PRZEMYSŁ CHEMICZNY 1, no. 7 (July 5, 2016): 119–22. http://dx.doi.org/10.15199/62.2016.7.16.

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Walkner, Laurie, Tanya M. Uden-Holman, Jeneane Moody, and Joy Harris. "The Role of the Public Health Training Centers in Advancing Public Health Department Accreditation." Pedagogy in Health Promotion 3, no. 1_suppl (May 11, 2017): 64S—66S. http://dx.doi.org/10.1177/2373379917691980.

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In the past few years, the drive for public health department accreditation has continued to build momentum. As the Centers for Disease Control and Prevention notes, “Engaging in accreditation catalyzes quality and performance improvement within all public health programs and can help health departments be better prepared to proactively respond to emerging and reemerging health challenges”. Many organizations support accreditation efforts, including the Public Health Training Centers (PHTCs), which have been providing workforce development support since 1999. This article describes how one PHTC, the Midwestern Public Health Training Center, has supported capacity building for accreditation in partnership with other state-based organizations through the development of three major accreditation readiness activities: accreditation workshops, informational videos on Public Health Accreditation Board standards and measures, and competency-based workforce development assessments. Given the current and emerging public health challenges, the need for a well-prepared workforce is more important than ever to strengthen the public health system, and by engaging in activities to meet the accreditation standards, public health departments will be better positioned to respond to these challenges. PHTCs will continue to have a critical role in capacity building for accreditation.

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Noblet, Thomas, Laurent Dreesen, Abderrahmane Tadjeddine, and Christophe Humbert. "Spatial Dependence of the Dipolar Interaction between Quantum Dots and Organic Molecules Probed by Two-Color Sum-Frequency Generation Spectroscopy." Symmetry 13, no. 2 (February 9, 2021): 294. http://dx.doi.org/10.3390/sym13020294.

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Given the tunability of their optical properties over the UV–Visible–Near IR spectral range, ligand-capped quantum dots (QDs) are employed for the design of optical biosensors with low detection threshold. Thanks to non-linear optical spectroscopies, the absorption properties of QDs are indeed used to selectively enhance the local vibrational response of molecules located in their vicinity. Previous studies led to assume the existence of a vibroelectronic QD–molecule coupling based on dipolar interaction. However, no systematic study on the strength of this coupling has been performed to date. In order to address this issue, we use non-linear optical Two-Color Sum-Frequency Generation (2C-SFG) spectroscopy to probe thick QD layers deposited on calcium fluoride (CaF2) prisms previously functionalized by a self-assembled monolayer of phenyltriethoxysilane (PhTES) molecules. Here, 2C-SFG is performed in Attenuated Total Reflection (ATR) configuration. By comparing the molecular vibrational enhancement measured for QD–ligand coupling and QD–PhTES coupling, we show that the spatial dependence of the QD–molecule interactions (∼1/r3, with r the QD–molecule distance) is in agreement with the hypothesis of a dipole–dipole interaction.

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Shan, Wei Jun, Wei Wang, and Hong Qiang Ru. "Synthesis of Plugged Mesoporous SBA-15-Type Silicas from Sodium Silicate." Key Engineering Materials 512-515 (June 2012): 568–74. http://dx.doi.org/10.4028/www.scientific.net/kem.512-515.568.

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Nonionic triblock copolymers (P123) templated SBA-15 silicas since 1998 have attracted great interests due to their larger pores, thicker pore walls, etc. Following that, extensive works were devoted to tailor the textural and morphological properties of SBA-15s, among which the SBA-15 with plugs formed in mesoschannels, called plugged hexagonal templated silica (PHTS), was one of famous examples. This work presents a simple but effective method to prepare PHTS-type SBA-15s based on the partitioned cooperative self-assembly process using P123 as template and cheap sodium silicate as silica precursor, which is in contrast with most other works using TEOS as silica precursor. Various techniques, including XRD, TEM and N2 sorption, have been employed to characterize the resultant PHTS-type SBA-15s. For this method, synthetic parameters, especially the interval time and aging temperatures, were found to have great influence on the plugged mesostructures.

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Eufrazino, Cátia, Andreia Veras, and Francisco Bandeira. "Epidemiology of Primary Hyperparathyroidism and its Non-classical Manifestations in the City of Recife, Brazil." Clinical Medicine Insights: Endocrinology and Diabetes 6 (January 2013): CMED.S13147. http://dx.doi.org/10.4137/cmed.s13147.

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Before the introduction of routine measurements of serum calcium in ambulatory services, PHTP (primary hyperparathyroidism) was symptomatic with classic bone disease (known as osteitis fibrosa cystica) nephrolithiasis, and acute neuropsychiatric syndrome with severe hypercalcemia. Currently, PHPT presents few unspecific symptoms. This cross-sectional study was conducted from December 1, 2007, through August 31, 2008 to estimate the prevalence of primary hyperparathyroidism and to describe the clinical and laboratory characteristics of patients receiving ambulatory care. From 4207 patients, we found a prevalence of PHTP of 0.78 (95% confidence interval [CI], 0.52–1.04) of which 81.8% were asymptomatic and 18.2% symptomatic. The female:male ratio was 7.2:1, and 89.7% of the women were postmenopausal. Mean age was 61.12 ± 15.73 years, mean serum calcium was 10.63 ± 1.33 mg/dL, and mean serum parathyroid hormone (PTH) was 182.48 ± 326.51 pg/mL. We found a high prevalence of PHTP at reference centers and a high prevalence of hypertension and type 2 diabetes.

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Tischkowitz, Marc, Chrystelle Colas, Sjaak Pouwels, and Nicoline Hoogerbrugge. "Cancer Surveillance Guideline for individuals with PTEN hamartoma tumour syndrome." European Journal of Human Genetics 28, no. 10 (June 12, 2020): 1387–93. http://dx.doi.org/10.1038/s41431-020-0651-7.

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Abstract PTEN hamartoma tumour syndrome is a diverse multi-system disorder predisposing to the development of hamartomatous growths, increasing risk of breast, thyroid, renal cancer, and possibly increasing risk of endometrial cancer, colorectal cancer and melanoma. There is no international consensus on cancer surveillance in PHTS and all current guidelines are based on expert opinion. A comprehensive literature review was undertaken and guidelines were developed by clinicians with expertise from clinical genetics, gynaecology, endocrinology, dermatology, radiology, gastroenterology and general surgery, together with affected individuals and their representatives. Recommendations were put forward for surveillance for breast, thyroid and renal cancers. Limited recommendations were developed for other sites including endometrial, colon and skin. The proposed cancer surveillance recommendations for PHTS require a coordinated multidisciplinary approach and significant patient commitment. The evidence base for cancer surveillance in this guideline are limited, emphasising the need for prospective evaluation of the effectiveness of surveillance in the PHTS population.

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Baran, Julia A., Steven D. Tsai, Amber Isaza, Garrett M. Brodeur, Suzanne P. MacFarland, Kristin Zelley, Denise M. Adams, Aime T. Franco, and Andrew J. Bauer. "The Clinical Spectrum of PTEN Hamartoma Tumor Syndrome: Exploring the Value of Thyroid Surveillance." Hormone Research in Paediatrics 93, no. 11-12 (2020): 634–42. http://dx.doi.org/10.1159/000515731.

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Introduction: Phosphatase and tensin homolog (PTEN) hamartoma tumor syndrome (PHTS) comprises a collection of clinical features characterized by constitutional variants in PTEN. Several guidelines recommend thyroid screening, beginning at the pediatric age at the time of PHTS diagnosis; however, the benefits of early surveillance has not been well defined. Methods: We conducted a retrospective investigation of patients followed up at the Children’s Hospital of Philadelphia with a diagnosis of PHTS between January 2003 and June 2019. In total, 81 patients younger than 19 years were identified. Results: The most common clinical feature at presentation was macrocephaly (85.1%), followed by impaired development (42.0%), skin/oral lesions (30.9%), and autism spectrum disorder (27.2%). A total of 58 of 81 patients underwent thyroid surveillance, with 30 patients (51.7%) found to have a nodule(s). Ultimately, 16 patients underwent thyroidectomy, with 7.4% (6/81) diagnosed with thyroid cancer. All thyroid cancer patients were older than 10 years at diagnosis, and all displayed low-invasive behavior. Of the patients younger than 10 years at the time of thyroid ultrasound (US) surveillance, 71.4% (15/21) had a normal US. The remaining 6 patients had thyroid nodules, including 4 undergoing thyroid surgery with benign histology. Discussion/Conclusion: Patients with macrocephaly, impaired cognitive development and thyroid nodules, and/or early-onset gastrointestinal polyps should undergo constitutional testing for PHTS. There does not appear to be a clinical advantage to initiating thyroid US surveillance before 10 years of age. In PHTS patients with a normal physical examination, thyroid US surveillance can be delayed until 10 years of age.

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Zare, Davood, Alessandro Prescimone, Edwin C. Constable, and Catherine E. Housecroft. "Where Are the tpy Embraces in [Zn{4′-(EtO)2OPC6H4tpy}2][CF3SO3]2?" Crystals 8, no. 12 (December 10, 2018): 461. http://dx.doi.org/10.3390/cryst8120461.

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In this paper, the bromo- and phosphonate-ester-functionalized complexes [Zn(1)2][CF3SO3]2 and [Zn(2)2][CF3SO3]2 (1 = 4′-(4-bromophenyl)-2,2′:6′,2″-terpyridine, 2 = diethyl (4-([2,2′:6′,2″-terpyridin]-4′-yl)phenyl)phosphonate) are reported. The complexes have been characterized by electrospray mass spectrometry, IR and absorption spectroscopies, and multinuclear NMR spectroscopy. The single-crystal structures of [Zn(1)2][CF3SO3]2.MeCN.1/2Et2O and [Zn(2)2][CF3SO3]2 have been determined and they confirm {Zn(tpy)2}2+ cores (tpy = 2,2′:6′,2″-terpyridine). Ongoing from X = Br to P(O)(OEt)2, the {Zn(4′-XC6H4tpy)2}2+ unit exhibits significant “bowing” of the backbone, which is associated with changes in packing interactions. The [Zn(1)2]2+ cations engage in head-to-tail 4′-Phtpy...4′-Phtpy embraces with efficient pyridine...phenylene π-stacking interactions. The [Zn(2)2]2+ cations pack with one of the two ligands involved in pyridine...pyridine π-stacking; steric hindrance between one C6H4PO(OEt)2 group and an adjacent pair of π-stacked pyridine rings results in distortion of backbone of the ligand. This report is the first crystallographic determination of a salt of a homoleptic [M{4′-(RO)2OPC6H4tpy}2]n+ cation.

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Yehia, Lamis, and Charis Eng. "65 YEARS OF THE DOUBLE HELIX: One gene, many endocrine and metabolic syndromes: PTEN-opathies and precision medicine." Endocrine-Related Cancer 25, no. 8 (August 2018): T121—T140. http://dx.doi.org/10.1530/erc-18-0162.

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An average of 10% of all cancers (range 1–40%) are caused by heritable mutations and over the years have become powerful models for precision medicine practice. Furthermore, such cancer predisposition genes for seemingly rare syndromes have turned out to help explain mechanisms of sporadic carcinogenesis and often inform normal development. The tumor suppressor PTEN encodes a ubiquitously expressed phosphatase that counteracts the PI3K/AKT/mTOR cascade – one of the most critical growth-promoting signaling pathways. Clinically, individuals with germline PTEN mutations have diverse phenotypes and fall under the umbrella term PTEN hamartoma tumor syndrome (PHTS). PHTS encompasses four clinically distinct allelic overgrowth syndromes, namely Cowden, Bannayan-Riley-Ruvalcaba, Proteus and Proteus-like syndromes. Relatedly, mutations in other genes encoding components of the PI3K/AKT/mTOR pathway downstream of PTEN also predispose patients to partially overlapping clinical manifestations, with similar effects as PTEN malfunction. We refer to these syndromes as ‘PTEN-opathies.’ As a tumor suppressor and key regulator of normal development, PTEN dysfunction can cause a spectrum of phenotypes including benign overgrowths, malignancies, metabolic and neurodevelopmental disorders. Relevant to clinical practice, the identification of PTEN mutations in patients not only establishes a PHTS molecular diagnosis, but also informs on more accurate cancer risk assessment and medical management of those patients and affected family members. Importantly, timely diagnosis is key, as early recognition allows for preventative measures such as high-risk screening and surveillance even prior to cancer onset. This review highlights the translational impact that the discovery of PTEN has had on the diagnosis, management and treatment of PHTS.

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Vlad-Oros, B., G. Preda, Z. Dudas, M. Dragomirescu, and A. Chiriac. "Entrapment of glucoamylase by sol-gel technique in PhTES/TEOS hybrid matrixes." Processing and Application of Ceramics 1, no. 1-2 (2007): 63–67. http://dx.doi.org/10.2298/pac0702063v.

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Mesoporous silica particles were prepared by the sol-gel method from different alkoxysilane precursors and used as a host matrix for encapsulation of glucoamylase, an enzyme widely used in fermentative industry. The aim was to investigate the physico-chemical properties of the different silica powders and their effect on the enzyme kinetics. The encapsulated enzymes followed Michaelis-Menten kinetics. The Michaelis constant (KM) and the maximum rate of starch hydrolysis reaction (Vmax) were calculated according to the Michaelis-Menten and Lineweaver-Burke plots. The values of the Michaelis constant (KM) of the encapsulated enzymes were higher than those of the free enzyme. The temperature and pH influence on the activity of free and immobilized glucoamylase were also compared. The results of this study show that the enzymes immobilized in organic/inorganic hybrid silica matrixes (obtained by the sol-gel method), allowing the entrapped glucoamylase to retain its biological activity, are suitable for many different applications, (medicinal, clinical, analytical).

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Moritz, Michał, and Małgorzata Geszke-Moritz. "Sulfonic Acid Derivative-Modified SBA-15, PHTS and MCM-41 Mesoporous Silicas as Carriers for a New Antiplatelet Drug: Ticagrelor Adsorption and Release Studies." Materials 13, no. 13 (June 29, 2020): 2913. http://dx.doi.org/10.3390/ma13132913.

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Three mesoporous, siliceous materials, i.e., SBA-15 (Santa Barbara Amorphous), PHTS (Plugged Hexagonal Templated Silica) and MCM-41 (Mobil Composition of Matter), functionalized with a sulfonic acid derivative, were successfully prepared and applied as the carriers for the poorly water-soluble drug, ticagrelor. The siliceous carriers were characterized using nitrogen sorption analysis, X-ray diffraction (XRD), transmission electron microscopy (TEM) and elemental analysis. The adsorption studies were conducted in acetonitrile. At the highest equilibrium concentrations, the amount of ticagrelor Qe that adsorbed onto the examined silicas was in the range of 83 to 220 mg/g, increasing in the following order: PHTS-(CH2)3-SO3H < SBA-15-(CH2)3-SO3H < MCM-41-(CH2)3-SO3H. The equilibrium adsorption data were analyzed using the Freundlich, Jovanovich, Langmuir, Temkin, Dubinin-Radushkevich, Dubinin-Astakhov and Redlich-Peterson models. In order to find the best-fit isotherm for each model, a nonlinear fitting analysis was carried out. Based on the minimized values of the ARE function, the fit of the isotherms to the experimental points for ticagrelor adsorption onto the modified silicas can be ordered as follows: SBA-15-(CH2)3-SO3H (Redlich-Peterson > Dubinin-Astakhov > Temkin), PHTS-(CH2)3-SO3H (Redlich-Peterson > Temkin > Dubinin-Astakhov), MCM-41-(CH2)3-SO3H (Redlich-Peterson > Dubinin-Astakhov > Langmuir). The values of adsorption energy (above 8 kJ/mol) indicate the chemical nature of ticagrelor adsorption onto propyl-sulfonic acid-modified silicas. The results of release studies indicated that at pH 4.5, modified SBA-15 and MCM-41 carriers accelerate the drug dissolution process, compared to the dissolution rate of free crystalline ticagrelor. Intriguingly, modified PHTS silica provides prolonged drug release kinetics compared to other siliceous adsorbents and to the dissolution rate of crystalline ticagrelor. A Weibull release model was employed to describe the release profiles of ticagrelor from the prepared carriers. The time necessary to dissolve 50% and 90% of ticagrelor from mesoporous adsorbents at pH 4.5 increased in the following order: SBA-15-(CH2)3-SO3H < MCM-41-(CH2)3-SO3H < PHTS-(CH2)3-SO3H.

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Yoo, Raphael, Alex Chau, Daniel Ashton, Judith Margolin, Ionela Iacobas, and Sheena Pimpalwar. "Temporal Evolution and Management of Fast Flow Vascular Anomalies in PTEN Hamartoma Tumor Syndrome." International Journal of Angiology 27, no. 03 (June 28, 2018): 158–64. http://dx.doi.org/10.1055/s-0038-1661377.

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AbstractPhosphatase and tensin homolog (PTEN) hamartoma tumor syndrome (PHTS) is characterized by formation of recurrent benign tumors described as PTEN hamartoma of soft tissue that may contain fast flow vascular anomalies (FFVA). The purpose of this study is to review the temporal evolution and management of FFVA in PHTS. A retrospective review of 22 patients (9 males), age 1 to 18 (median 9) years diagnosed with PHTS at a tertiary care pediatric hospital between October 2002 and August 2017 revealed 4 patients with FFVA. Imaging, management, and treatment complications were reviewed. During median follow-up of 8 (range: 4–13) years, ultrasound and magnetic resonance imaging performed for recurrent pain, showed progressive increase in the size of hamartomas and development of new FFVA in three-fourth patients. Medical management included pain medications, oral sirolimus, and physical and psychiatric therapy. Surgical excision of hamartoma (n = 1) resulted in recurrence within 3 months. Between 4 and 24 (average 1.5/year) embolizations were performed per patient. Pain related to FFVA responded well to embolization. Pain secondary to PTEN hamartoma responded poorly to percutaneous sclerosant injection, but demonstrated improvement with sirolimus. There was no correlation between serum sirolimus levels and frequency/timing of recurrence of FFVA/hamartoma. Complications included sclerosant migration into digital arteries (n = 1), subclavian vein stenosis due to glue migration (n = 1), oral mucositis (n = 4), and elevated triglycerides (n = 4). Patients with PHTS present with recurrent pain requiring life-long management with a multi-disciplinary team. Pain due to FFVA responds to embolization, and pain due to hamartoma responds to sirolimus. This improves quality of life, but does not prevent disease progression.

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Wan, Yuanyuan, Zhen Wang, Jichun Xia, Shulin Shen, Mingwei Guan, Meichen Zhu, Cailin Qiao, et al. "Genome-Wide Analysis of Phosphorus Transporter Genes in Brassica and Their Roles in Heavy Metal Stress Tolerance." International Journal of Molecular Sciences 21, no. 6 (March 23, 2020): 2209. http://dx.doi.org/10.3390/ijms21062209.

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Phosphorus transporter (PHT) genes encode H2PO4−/H+ co-transporters that absorb and transport inorganic nutrient elements required for plant development and growth and protect plants from heavy metal stress. However, little is known about the roles of PHTs in Brassica compared to Arabidopsis thaliana. In this study, we identified and extensively analyzed 336 PHTs from three diploid (B. rapa, B. oleracea, and B. nigra) and two allotetraploid (B. juncea and B. napus) Brassica species. We categorized the PHTs into five phylogenetic clusters (PHT1–PHT5), including 201 PHT1 homologs, 15 PHT2 homologs, 40 PHT3 homologs, 54 PHT4 homologs, and 26 PHT5 homologs, which are unevenly distributed on the corresponding chromosomes of the five Brassica species. All PHT family genes from Brassica are more closely related to Arabidopsis PHTs in the same vs. other clusters, suggesting they are highly conserved and have similar functions. Duplication and synteny analysis revealed that segmental and tandem duplications led to the expansion of the PHT gene family during the process of polyploidization and that members of this family have undergone purifying selection during evolution based on Ka/Ks values. Finally, we explored the expression profiles of BnaPHT family genes in specific tissues, at various developmental stages, and under heavy metal stress via RNA-seq analysis and qRT-PCR. BnaPHTs that were induced by heavy metal treatment might mediate the response of rapeseed to this important stress. This study represents the first genome-wide analysis of PHT family genes in Brassica species. Our findings improve our understanding of PHT family genes and provide a basis for further studies of BnaPHTs in plant tolerance to heavy metal stress.

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Sapsford, W. "Should the ‘C’ in ‘ABCDE’ Be Altered to Reflect the Trend towards Hypotensive Resuscitation?" Scandinavian Journal of Surgery 97, no. 1 (March 2008): 4–11. http://dx.doi.org/10.1177/145749690809700102.

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Background: Fluid resuscitation of trauma victims currently differs, depending on whether the Advanced Trauma Life Support (ATLS), Prehospital Trauma Life Support (PHTLS) or Battlefield Advanced Trauma Life Support (BATLS) algorithm is utilised. Resuscitation protocol depends on the situation of the patient before definitive surgical control of the haemorrhage can be achieved, that is, in the prehospital phase (the urban, rural or battlefield setting) or in the emergency room. The principle difference is between hypotensive (PHTLS and BATLS, in the prehospital phase) and normotensive (ATLS, in the emergency room) resuscitation. The aim of this review was to determine if there is sufficient evidence to consider altering the ATLS resuscitation algorithm to a hypotensive model prior to definitive surgical control of haemorrhage. Method: A literature review was conducted of the experimental and clinical evidence for hypotensive resuscitation. Results: Uncontrolled haemorrhage models are too severe. They do not realistically mimic — And their results cannot easily be extrapolated into — Clinical scenarios. One important clinical trial, inspired by these experimental models, has rightly influenced resuscitation of shocked prehospital patients towards a ‘scoop and run’ approach and permissive hypotension but it is specific to patients with penetrating trauma alone. Conclusion: There is insufficient evidence to alter the current ATLS algorithm in the emergency room in favour of hypotensive resuscitation. The future of resuscitation is considered.

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Chatterjee, B., S. K. Gupta, H. S. Kushwaha, and V. Venkat Raj. "Analysis of the Thermal Hydraulic Consequences Following Common Mode Pump Seizure in a Nuclear Power Plant." Journal of Pressure Vessel Technology 124, no. 4 (November 1, 2002): 415–17. http://dx.doi.org/10.1115/1.1465437.

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In nuclear power plants, the primary heat transport system (PHTS) is designed according to ASME Section 3 Division 1. The PHTS together with Primary Coolant Pumps (PCPs) is designed so that the integrity under safe shutdown earthquake (SSE) is maintained. However, the operability under SSE may not be ensured. There might be a possibility of seizure of PCPs under SSE. The pump seizure has two thermal hydraulic effects. The flow sharply reduces and the kinetic energy of the fluid gets converted into pressure pulses. The magnitude of the pulse depends on the locked pump rotor flow resistance. The reduction in the flow affects the heat transfer in the core and the steam generator in different ways. This mismatch between the heat received and rejected by the PHTS results in high system pressure inspite of relief valves. This paper presents and discusses the aforementioned two effects for the case of a PHWR. The study shows that the peak pressure reached during the transient is much higher than the operating pressure. The system integrity may be affected if the peak pressure is significantly higher than the design pressure.

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Lai, Yi Qiang. "Rotation Moment Invariant Feature Extraction Techniques for Image Matching." Applied Mechanics and Materials 721 (December 2014): 775–78. http://dx.doi.org/10.4028/www.scientific.net/amm.721.775.

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In recently years, extracting images invariance features are gaining more attention in image matching field. Various types of methods have been used to match image successfully in a number of applications. But in mostly literatures, the rotation moment invariant properties of these invariants have not been studied widely. In this paper, we present a novel method based on Polar Harmonic Transforms (PHTs) which is consisted of a set of orthogonal projection bases to extract rotation moment invariant features. The experimental results show that the kernel computation of PHTs is simple and image features is extracted accurately in image matching. Hence polar harmonic transforms have provided a powerful tool for image matching.

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Quaytman, Jacob, Yuri E. Nikiforov, Marina Nikiforova, and Elena Morariu. "Clinicopathologic Characteristics of Thyroid Nodules Positive for PTEN Mutations on Preoperative Molecular Testing." Journal of the Endocrine Society 5, Supplement_1 (May 1, 2021): A1013—A1014. http://dx.doi.org/10.1210/jendso/bvab048.2073.

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Abstract Somatic and germline mutations of PTEN tumor suppressor gene are associated with follicular-pattern thyroid tumors and PTEN Hamartoma Tumor Syndrome (PHTS). The incidence of cancer in thyroid nodules positive for PTEN mutations on fine-needle aspiration (FNA) is not well defined. The aim of this study was to characterize diagnostic and phenotypic features of thyroid nodules with preoperatively detected PTEN mutations and their impact on management. Thyroid nodules with PTEN mutations on ThyroSeq v3 GC testing of FNA and core needle biopsy specimens from November 2017 to July 2020 were identified from the ThyroSeq Molecular Database. Demographic and clinicopathologic data were obtained through retrospective chart review. We identified 49 PTEN mutation-positive nodules from 48 patients. Patients were 57 years old on average (range 14-88) and 80% female. Cytology was predominantly indeterminate (73% atypia of undermined significance, 18% follicular neoplasm). There were 18 (29%) frameshift, 6 (10%) splice site, and 39 (62%) single nucleotide variant PTEN mutations. Fourteen (29%) nodules had two PTEN mutations, 5 (10%) had copy number alterations, and single cases had concurrent BRAF K601N, EZH1, and NRAS mutations. Surveillance was pursued for 27 (56%) and surgery for 21 (44%) patients (16 lobectomies, 5 total thyroidectomies). There were 14 follicular adenomas (FA), 4 oncocytic FA’s, 1 oncocytic hyperplastic nodule, and 1 encapsulated follicular variant papillary thyroid carcinoma (EFVPTC). The EFVPTC had two low-frequency PTEN mutations, PTEN locus loss, an NRAS mutation, and was a low-risk tumor with capsular but no angiolymphatic invasion. Four (8.3%) patients had confirmed or suspected PHTS, all with multiple nodules. Two had surgery finding no malignancies (2 FA). One PHTS patient had a prior thyroidectomy for a MET mutation-positive nodule that was follicular carcinoma. On US, the mean nodule size of patients who had surgery was larger than the surveillance group (3.2 cm vs. 2.3 cm, p=0.02) but there was no difference in TI-RADS level (p=0.54). There was no difference in mean nodule size (3.5 cm vs. 2.6 cm, p=0.35) or TI-RADS level (p=0.81) between PHTS and non-PHTS patients. Among surveillance patients, follow-up US was done at 1 year in 13/19 (68%) and 2 years in 3/6 (50%) of eligible cases. Only 1/19 (5%) underwent repeat FNA for increased nodule size. No thyroid malignancy was found with a mean of 1.75 years of follow-up (range 1.00-2.78). The EFVPTC patient had no recurrence after 1.05 years of follow-up. In summary, thyroid nodules with isolated somatic PTEN mutations are primarily benign and can be safely followed with serial imaging. Nodules with multiple PTEN mutations were only associated with malignancy when accompanied by an additional NRAS mutation. About 8% of patients with PTEN mutations may be PHTS patients who may be at greater risk for malignancy.

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Sorin, Evgeny S., Rose K. Baimuratova, Dmitry A. Chernyayev, Denis V. Korchagin, Igor E. Uflyand, and Gulzhian I. Dzhardimalieva. "New Mixed-Ligand Metal-Containing Monomer Based on Cobalt Acrylate and 4-Phenyl-2,2':6',2″-Terpyridine Ligand: Synthesis, Characteristics and Thermal Properties." Key Engineering Materials 899 (September 8, 2021): 37–44. http://dx.doi.org/10.4028/www.scientific.net/kem.899.37.

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New complex based on cobalt (II) acrylate and 4′-phenyl-2,2′:6′,2″-terpyridine (PhTpy) was synthesized and characterized using a number of analytical techniques including IR and UV- vis spectroscopy, elemental, X-Ray and TGA/DSC analysis. The complex has high thermal stability and crystallinity. It is found that decomposition of the complex is accompanied by thermal polymerization of acrylic fragments that is a potential way for the preparation nanoparticles of metals or their oxides stabilized by the polymer matrix.

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Journal articles on the topic 'Phttps'

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