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Journal articles on the topic 'Physical culture (PC)'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Denysova, L., and V. Lavrov. "SWOT Analysis of Organizational and Management Processes in the Field of Physical Culture and Sport under the conditions of digital transformation." Scientific Journal of National Pedagogical Dragomanov University. Series 15. Scientific and pedagogical problems of physical culture (physical culture and sports), no. 3(162) (March 30, 2023): 125–31. http://dx.doi.org/10.31392/npu-nc.series15.2023.3k(162).25.

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This article presents how a SWOT analysis can be used to identify possibilities for optimizing organizational and management processes in the field of physical culture and sport (PC&S) under conditions of digital transformation. The method of system analysis was used to study situations of interaction and the structure of relationships between the elements of the management system within the field of physical culture and sport. The authors attempted to evaluate the state of the organizational and management structure of PC&S within the state sector through use of a SWOT analysis. Macro

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Griffith, Niall J. L. "Is cognition plus technology an unbounded system?" Cognitive Technologies and the Pragmatics of Cognition 13, no. 3 (2005): 583–613. http://dx.doi.org/10.1075/pc.13.3.10gri.

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The relationship between cognition and culture is discussed in terms of technology and representation. The computational metaphor is discussed in relation to its providing an account of cognitive and technical development: the role of representation and self-modification through environmental manipulation and the development of open learning from stigmery. A rationalisation for the transformational effects of information and representation is sought in the physical and biological theories of Autokatakinetics and Autopoiesis. The conclusion drawn is that culture, rather than being an intrinsic

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Byshevets, Nataliia, Nataliia Goncharova, and Yuliia Lazakovych. "Peculiarities of the educational activity of higher education students in physical culture and sports during the use of distance forms of learning." Scientific Journal of National Pedagogical Dragomanov University. Series 15. Scientific and pedagogical problems of physical culture (physical culture and sports), no. 11(143) (November 30, 2021): 29–33. http://dx.doi.org/10.31392/npu-nc.series15.2021.11(143).07.

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In order to improve the educational process in the conditions of quarantine restrictions, it is important to assess the characteristics of students' reaction, depending on the specialty in which they receive education, to certain pedagogical methods and techniques characteristic of distance learning. The purpose of the work is to investigate the dynamics of students' attitude to distance learning and to identify the features of the educational process in the information and educational environment of higher education institutions depending on the field of study. The study from 2020 to 20

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Stafeeva, A. V., L. V. Zasukhina, and D. S. Kuryatnikov. "EVALUATION OF PROFESSIONAL COMPETENCIES OF TEACHER TRAINING UNDERGRADUATES IN THE CONTEXT OF IMPLEMENTING THE UPDATED STANDARDS." Scientific Notes of V.I. Vernadsky Crimean Federal University. Sociology. Pedagogy. Psychology 6(72), no. 3 (2020): 46–55. http://dx.doi.org/10.37279/2413-1709-2020-6-3-46-55.

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The article deals with the issues of training master’s students in the pedagogical direction of training in the context of updated standards of higher education. The authors propose forms and criteria for evaluating the professional competence of the PC-1 based on the Federal state educational standard Three plus plus training directions 44.04.01 «Pedagogical education», the profile «Educational technologies in the field of physical culture», and the professional standard. In the NSPU Kozma Minin (hereinafter referred to as Minin University) is currently implementing the main professional educ

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Byshevets, Nataliia, Vitalii Kashuba, Lubov Levandovska, et al. "Risk Factors for Posture Disorders of Esportsmen and Master Degree Students of Physical Education and Sports in the Specialty “Esports”." Sport i Turystyka. Środkowoeuropejskie Czasopismo Naukowe 5, no. 4 (2022): 97–118. http://dx.doi.org/10.16926/sit.2022.04.06.

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The purpose of this study was to investigate the risk factors for posture disorders in esportsmen and master’s degree students of physical culture and sports. The research involved 37 sportsmen and students. The research has found out that 32.4% of the respondents spend more than six hours a day on a computer. The research has proven that the posture of the respondents is most negatively affected by the reduced strength level of the lower extremities and torso, lack of active breaks during long work with a personal computer (PC), lack of awareness in the prevention of posture disorders when wo

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Bobkov, Vitaly V. "Features of the organization of the GTO festivals in universities of Moscow." Physical Education and University Sport 1, no. 2 (2022): 137–42. http://dx.doi.org/10.18500/2782-4594-2022-1-2-137-142.

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The relevance of this study is due to the high level of attention of the state policy in the field of physical culture and sports (PC&S), namely in the part of the All-Russian physical culture and sports complex “Ready for Labor and Defense” (VFSK GTO). According to the development strategy of PC&S for the period up to 2030 (the program “Priority – 2030”), the VFSK GTO is given an increasingly significant role in improving the level of physical activity and fitness level of the population. The purpose of the study is to determine the scheme of cooperation between educational institutio

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7

Fornara, Chiara, Eric Schultz, Daniele Lilleri, Fausto Baldanti, Brent Ryckman, and Giuseppe Gerna. "Fibroblast, Epithelial and Endothelial Cell-Derived Human Cytomegalovirus Strains Display Distinct Neutralizing Antibody Responses and Varying Levels of gH/gL Complexes." International Journal of Molecular Sciences 24, no. 5 (2023): 4417. http://dx.doi.org/10.3390/ijms24054417.

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In sequential sera from pregnant women with HCMV primary infection (PI), the serum neutralizing activity is higher against virions produced in epithelial and endothelial cells than in fibroblasts. Immunoblotting shows that the pentamer complex/trimer complex (PC/TC) ratio varies according to the producer cell culture type used for the virus preparation to be employed in the neutralizing antibody (NAb) assay, and is lower in fibroblasts and higher in epithelial, and especially endothelial cells. The blocking activity of TC- and PC-specific inhibitors varies according to the PC/TC ratio of virus

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Stremmel, Wolfgang, Simone Staffer, and Ralf Weiskirchen. "Phosphatidylcholine Passes by Paracellular Transport to the Apical Side of the Polarized Biliary Tumor Cell Line Mz-ChA-1." International Journal of Molecular Sciences 20, no. 16 (2019): 4034. http://dx.doi.org/10.3390/ijms20164034.

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Phosphatidylcholine (PC) translocation into mucus of the intestine was shown to occur via a paracellular transport across the apical/lateral tight junction (TJ) barrier. In case this could also be operative in biliary epithelial cells, this may have implication for the pathogenesis of primary sclerosing cholangitis (PSC). We here evaluated the transport of PC across polarized cholangiocytes. Therefore, the biliary tumor cell line Mz-ChA-1 was grown to confluency. In transwell culture systems the translocation of PC to the apical compartment was analyzed. After 21 days in culture, polarized Mz-

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Maurer, Julian, Thorsten Walles, and Cornelia Wiese-Rischke. "Optimization of Primary Human Bronchial Epithelial 3D Cell Culture with Donor-Matched Fibroblasts and Comparison of Two Different Culture Media." International Journal of Molecular Sciences 24, no. 4 (2023): 4113. http://dx.doi.org/10.3390/ijms24044113.

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In vitro airway models are increasingly important for pathomechanistic analyses of respiratory diseases. Existing models are limited in their validity by their incomplete cellular complexity. We therefore aimed to generate a more complex and meaningful three-dimensional (3D) airway model. Primary human bronchial epithelial cells (hbEC) were propagated in airway epithelial cell growth (AECG) or PneumaCult ExPlus medium. Generating 3D models, hbEC were airlifted and cultured on a collagen matrix with donor-matched bronchial fibroblasts for 21 days comparing two media (AECG or PneumaCult ALI (PC

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Shiv, Kumar Bunkar, Khalid Akhtar Syed, Meena Naresh, and Rakesh Saksham. "A Prospective Randomized Study of Comparison between Primary Vs Delayed Primary Skin Closure in Gastro Intestinal Perforation Peritonitis." International Journal of Pharmaceutical and Clinical Research 15, no. 6 (2023): 825–32. https://doi.org/10.5281/zenodo.12210076.

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<strong>Introduction:</strong> Peritonitis is one of the most common surgical emergencies encountered in day-to-day practice. <strong>Aim:</strong> comparison of primary skin closure technique and delayed primary skin closure technique. <strong>Methods:</strong> A prospective, randomized, single blinded trial of 60 patients was done in Department of General Surgery at the J.L.N. Medical College & Hospital, Ajmer from August 2021 to Dec 2022. In all the cases a detailed history, physical examination and investigation were done as per proforma. <strong>Results:<

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Hybel, Trine Engelbrecht, Dorothea Dietrichs, Jayashree Sahana, et al. "Simulated Microgravity Influences VEGF, MAPK, and PAM Signaling in Prostate Cancer Cells." International Journal of Molecular Sciences 21, no. 4 (2020): 1263. http://dx.doi.org/10.3390/ijms21041263.

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Prostate cancer is one of the leading causes of cancer mortality in men worldwide. An unusual but unique environment for studying tumor cell processes is provided by microgravity, either in space or simulated by ground-based devices like a random positioning machine (RPM). In this study, prostate adenocarcinoma-derived PC-3 cells were cultivated on an RPM for time periods of 3 and 5 days. We investigated the genes associated with the cytoskeleton, focal adhesions, extracellular matrix, growth, survival, angiogenesis, and metastasis. The gene expression of signaling factors of the vascular endo

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Pathan, Sumaiyya, Jeetu Narware, and Aniruddha G. Deshmukh. "Possibility of Evolving High Yielding Varieties of Oyster Mushroom through Anastomosis and Mutation." International Journal of Current Microbiology and Applied Sciences 12, no. 10 (2023): 111–20. http://dx.doi.org/10.20546/ijcmas.2023.1210.014.

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High production and good quality are always the principal goals for agriculturally important crop. Oyster mushroom is the choicest edible species cultivated in various region of the world. The yield performance improvement was carried out through hyphal anastomosis of four oyster mushroom viz., Pleurotus sajor-caju (Ps), P. citrinopleatus (Pc), P. florida (Pf) and Hypsizygus ulmaius (Hu) with each other and by physical mutation that comprised the exposure of mushroom culture to UV radiation and by chemical mutation by Ethyl Methyl Sulfonate (EMS). Date of spawning, days required for spawn run,

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13

Vendrell-Morancho, Mireia. "Pautas para mejorar la evaluación del pensamiento crítico en ciencias de la actividad física y del deporte en estudiantes universitarios (Guidelines for improving critical thinking assessment in physical activity and sports sciences among university students)." Retos 52 (January 21, 2024): 471–81. http://dx.doi.org/10.47197/retos.v52.101302.

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El Pensamiento Crítico (PC) se considera una competencia fundamental en la educación del siglo XXI debido a sus beneficios en los ámbitos académicos, personales, profesionales y sociales. Sin embargo, la evaluación del PC en estudiantes universitarios enfrenta desafíos en la conceptualización, diseño, criterios de enseñanza y evaluación, así como en el análisis de datos. Este artículo presenta pautas basadas en investigación para facilitar la promoción y evaluación efectiva del PC en el campo de las Ciencias de la Actividad Física y del Deporte. Las pautas abarcan cuatro fases: definición del

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14

Enfield, N. J., and Anna Wierzbicka. "Introduction." Pragmatics and Cognition 10, no. 1-2 (2002): 1–25. http://dx.doi.org/10.1075/pc.10.1-2.02enf.

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Anthropologists and linguists have long been aware that the body is explicitly referred to in conventional description of emotion in languages around the world. There is abundant linguistic data showing expression of emotions in terms of their imagined ‘locus’ in the physical body. The most important methodological issue in the study of emotions is language, for the ways people talk give us access to ‘folk descriptions’ of the emotions. ‘Technical terminology’, whether based on English or otherwise, is not excluded from this ‘folk’ status. It may appear to be safely ‘scientific’ and thus cultu

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15

Morady Moghaddam, Mostafa, and Fatemeh Mozafari. "Orientalist representation of Iranian women in three American newspapers." International Review of Pragmatics 15, no. 1 (2023): 117–33. http://dx.doi.org/10.1163/18773109-01501005.

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Abstract This article explores three famous American newspapers as an attempt to find out how Iranian women are depicted in these three American newspapers. Three national newspapers (The New York Times, Los Angeles Times, and The Washington Post) were consulted as authority to gain information about Iranian women. Two hundred and thirteen headlines about Iranian women were identified in these three newspapers published over a period of 10 years. Through qualitative corpus analysis, we noticed that Iranian women are represented with regard to five generic categories (patterns): Ethics and Dres

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ElGindi, Mei, Ibrahim Hamed Ibrahim, Jiranuwat Sapudom, Anna Garcia-Sabate, and Jeremy C. M. Teo. "Engineered Microvessel for Cell Culture in Simulated Microgravity." International Journal of Molecular Sciences 22, no. 12 (2021): 6331. http://dx.doi.org/10.3390/ijms22126331.

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As the number of manned space flights increase, studies on the effects of microgravity on the human body are becoming more important. Due to the high expense and complexity of sending samples into space, simulated microgravity platforms have become a popular way to study these effects on earth. In addition, simulated microgravity has recently drawn the attention of regenerative medicine by increasing cell differentiation capability. These platforms come with many advantages as well as limitations. A main limitation for usage of these platforms is the lack of high-throughput capability due to t

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Al-Bader, Salah M. "Characterization and evaluation Typha domingensis Pers.) of a fungal growth medium composed pollens powder of cattail (." Innovaciencia Facultad de Ciencias Exactas Físicas y Naturales 6, no. 2 (2019): 1–7. http://dx.doi.org/10.15649/2346075x.480.

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Introduction: A great progressing occurs in microbiology Ulocladium sp. after culture media have been used in culturing, isolation, identification, and reservation of microorganisms. According to their components, culture media were divided into natural, synthetic, and semisynthetic, the natural medium contain almost all the nutritional requirements but in non-defined quantities. In the current work, the validity of Typha domingensis pollens as a new substrate for fungal culture medium was tested. Several physical and chemical characteristics of medium were detected. The growth of nine fungal

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Liu, Chunlin, Shiqin Chen, Yingying Shan, et al. "Screening of Ionic Liquids against Bamboo Mildew and Its Inhibition Mechanism." Molecules 28, no. 8 (2023): 3432. http://dx.doi.org/10.3390/molecules28083432.

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Ionic liquids are a class of organic molten salts that consist entirely of cations and anions. They are characterized by their low vapor pressure, low viscosity, low toxicity, high thermal stability, and strong antifungal potential. In this study, the inhibitory performance of ionic liquid cations against Penicillium citrinum, Trichoderma viride, and Aspergillus niger was investigated, along with the mechanism of cell membrane disruption. The Oxford cup method, SEM, and TEM were employed to examine the extent of damage and the specific site of action of ionic liquids on the mycelium and cell s

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Shao, Surun, Xueni Wang, Jianglian She, et al. "Diversified Chaetoglobosins from the Marine-Derived Fungus Emericellopsis sp. SCSIO41202." Molecules 27, no. 6 (2022): 1823. http://dx.doi.org/10.3390/molecules27061823.

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Two undescribed cytochalasins, emeriglobosins A (1) and B (2), together with nine previously reported analogues (3–11) and two known tetramic acid derivatives (12, 13) were isolated from the solid culture of Emericellopsis sp. SCSIO41202. Their structures, including the absolute configurations of their stereogenic carbons, were fully elucidated based on spectroscopic analysis and the calculated ECD. Some of the isolated compounds were evaluated for their cytotoxicity and enzyme inhibitory activity against acetylcholinesterase (AChE) in vitro. Among them, 8 showed potent AChE inhibitory activit

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Lee, Jaewook, Ji-Heon Lee, Jagannath Mondal, et al. "Magnetofluoro-Immunosensing Platform Based on Binary Nanoparticle-Decorated Graphene for Detection of Cancer Cell-Derived Exosomes." International Journal of Molecular Sciences 23, no. 17 (2022): 9619. http://dx.doi.org/10.3390/ijms23179619.

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Multi-functionalized carbon nanomaterials have attracted interest owing to their excellent synergic properties, such as plasmon resonance energy transfer and surface-enhanced Raman scattering. Particularly, nanoparticle (NP)-decorated graphene (GRP) has been applied in various fields. In this study, silver NP (AgNP)- and magnetic iron oxide NP (IONP)-decorated GRP were prepared and utilized as biosensing platforms. In this case, AgNPs and GRP exhibit plasmonic properties, whereas IONPs exhibit magnetic properties; therefore, this hybrid nanomaterial could function as a magnetoplasmonic substra

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Pietrowska-Borek, Małgorzata, Jędrzej Dobrogojski, Anna Maria Wojdyła-Mamoń, et al. "Nucleoside 5′-Phosphoramidates Control the Phenylpropanoid Pathway in Vitis vinifera Suspension-Cultured Cells." International Journal of Molecular Sciences 22, no. 24 (2021): 13567. http://dx.doi.org/10.3390/ijms222413567.

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It is known that cells contain various uncommon nucleotides such as dinucleoside polyphosphates (NpnN’s) and adenosine 5′-phosphoramidate (NH2-pA) belonging to nucleoside 5′-phosphoramidates (NH2-pNs). Their cellular levels are enzymatically controlled. Some of them are accumulated in cells under stress, and therefore, they could act as signal molecules. Our previous research carried out in Arabidopsis thaliana and grape (Vitis vinifera) showed that NpnN’s induced the expression of genes in the phenylpropanoid pathway and favored the accumulation of their products, which protect plants against

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Ghasemi, Mahshid, Tyron Turnbull, Sonia Sebastian, and Ivan Kempson. "The MTT Assay: Utility, Limitations, Pitfalls, and Interpretation in Bulk and Single-Cell Analysis." International Journal of Molecular Sciences 22, no. 23 (2021): 12827. http://dx.doi.org/10.3390/ijms222312827.

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The MTT assay for cellular metabolic activity is almost ubiquitous to studies of cell toxicity; however, it is commonly applied and interpreted erroneously. We investigated the applicability and limitations of the MTT assay in representing treatment toxicity, cell viability, and metabolic activity. We evaluated the effect of potential confounding variables on the MTT assay measurements on a prostate cancer cell line (PC-3) including cell seeding number, MTT concentration, MTT incubation time, serum starvation, cell culture media composition, released intracellular contents (cell lysate and sec

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Yeo, Changhwan, Deok-Soo Han, Hyo-Jeong Lee, and Eun-Ok Lee. "Epigallocatechin-3-Gallate Suppresses Vasculogenic Mimicry through Inhibiting the Twist/VE-Cadherin/AKT Pathway in Human Prostate Cancer PC-3 Cells." International Journal of Molecular Sciences 21, no. 2 (2020): 439. http://dx.doi.org/10.3390/ijms21020439.

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Vasculogenic mimicry (VM) is the alternative process of forming vessel-like networks by aggressive tumor cells, and it has an important role in tumor survival, growth, and metastasis. Epigallocatechin-3-gallate (EGCG) is well known to have diverse bioactivities including anti-cancer effects. However, the efficacy of EGCG on VM is elusive. In this study, we explored whether and how EGCG affects VM in human prostate cancer (PCa) PC-3 cells. Cell viability was measured by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Invasive and VM formation abilities were assessed by

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Hassan, Khadija, Blondelle Matio Kemkuignou, Marco Kirchenwitz, et al. "Neurotrophic and Immunomodulatory Lanostane Triterpenoids from Wood-Inhabiting Basidiomycota." International Journal of Molecular Sciences 23, no. 21 (2022): 13593. http://dx.doi.org/10.3390/ijms232113593.

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Neurotrophins such as nerve growth factor (ngf) and brain-derived neurotrophic factor (bdnf) play important roles in the central nervous system. They are potential therapeutic drugs for the treatment of neurodegenerative diseases, including Alzheimer’s disease and Parkinson’s disease. In this study, we investigated the neurotrophic properties of triterpenes isolated from fruiting bodies of Laetiporus sulphureus and a mycelial culture of Antrodia sp. MUCL 56049. The structures of the isolated compounds were elucidated based on nuclear magnetic resonance (NMR) spectroscopy in combination with hi

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Raitanen, Julia, Bernadette Barta, Hermann Fuchs, et al. "Radiobiological Assessment of Targeted Radionuclide Therapy with [177Lu]Lu-PSMA-I&T in 2D vs. 3D Cell Culture Models." International Journal of Molecular Sciences 24, no. 23 (2023): 17015. http://dx.doi.org/10.3390/ijms242317015.

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In vitro therapeutic efficacy studies are commonly conducted in cell monolayers. However, three-dimensional (3D) tumor spheroids are known to better represent in vivo tumors. This study used [177Lu]Lu-PSMA-I&T, an already clinically applied radiopharmaceutical for targeted radionuclide therapy against metastatic castrate-resistant prostate cancer, to demonstrate the differences in the radiobiological response between 2D and 3D cell culture models of the prostate cancer cell lines PC-3 (PSMA negative) and LNCaP (PSMA positive). After assessing the target expression in both models via Wester

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Ezova, Svetlana A., and Ekaterina A. Kuchmurukova. "“Library Environment and Space” is New Academic Discipline at the East-Siberian State Institute of Culture." Bibliotekovedenie [Russian Journal of Library Science] 69, no. 5 (2020): 539–51. http://dx.doi.org/10.25281/0869-608x-2020-69-5-539-551.

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The article is devoted to the theoretical justification of the training course “Library environment and space” and the experience of teaching it at the Department of library and information resources of the East Siberian State Institute of Culture (VSGIK). Interaction of library, environment and space is studied using environmental, contextual and spatial approaches. In order to clarify the system of terminology, the authors analyse publications of well-known specialists in library science considering the features of library environment and space. The authors determine the contexts of library

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Szczepańska, Patrycja, Magdalena Rychlicka, Paweł Moroz, Tomasz Janek, Anna Gliszczyńska, and Zbigniew Lazar. "Elevating Phospholipids Production Yarrowia lipolytica from Crude Glycerol." International Journal of Molecular Sciences 23, no. 18 (2022): 10737. http://dx.doi.org/10.3390/ijms231810737.

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Phospholipids (PLs) are a class of lipids with many proven biological functions. They are commonly used in lipid replacement therapy to enrich cell membranes damaged in chronic neurodegenerative diseases, cancer, or aging processes. Due to their amphipathic nature, PLs have been widely used in food, cosmetic, and pharmaceutical products as natural emulsifiers and components of liposomes. In Yarrowia lipolytica, PLs are synthesized through a similar pathway like in higher eukaryotes. However, PL biosynthesis in this yeast is still poorly understood. The key intermediate in this pathway is phosp

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Simoncini, Stéphanie, Simon Toupance, Carlos Labat, et al. "Functional Impairment of Endothelial Colony Forming Cells (ECFC) in Patients with Severe Atherosclerotic Cardiovascular Disease (ASCVD)." International Journal of Molecular Sciences 23, no. 16 (2022): 8969. http://dx.doi.org/10.3390/ijms23168969.

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Endothelial dysfunction is a key factor in atherosclerosis. However, the link between endothelial repair and severity of atherosclerotic cardiovascular disease (ASCVD) is unclear. This study investigates the relationship between ASCVD, markers of inflammation, and circulating endothelial progenitor cells, namely hematopoietic cells with paracrine angiogenic activity and endothelial colony forming cells (ECFC). Two hundred and forty-three subjects from the TELARTA study were classified according to the presence of clinical atherosclerotic disease. ASCVD severity was assessed by the number of in

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Pelliccia, Andrea, Francesco Capradossi, Francesca Corsi, et al. "Androgen Deprivation Freezes Hormone-Sensitive Prostate Cancer Cells in a Reversible, Genetically Unstable Quasi-Apoptotic State, Bursting into Full Apoptosis upon Poly(ADP-ribose) Polymerase Inhibition." International Journal of Molecular Sciences 24, no. 3 (2023): 2040. http://dx.doi.org/10.3390/ijms24032040.

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Androgen deprivation therapy (ADT) is a powerful treatment for metastatic hormone-sensitive prostate cancer (mHSPC) patients, but eventually and inevitably, cancer relapses, progressing to the fatal castration-resistant (CR)PC stage. Progression implies the emergence of cells proliferating in the absence of androgen through still elusive mechanisms. We show here for the first time that ADT induces LNCaP mHSPC cells to collectively enter a metastable quasi-apoptotic state (QUAPS) consisting of partial mitochondrial permeabilization, limited BAX and caspase activation, and moderate induction of

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Lam, Yen T. H., Manuel G. Ricardo, Robert Rennert, et al. "Rare Glutamic Acid Methyl Ester Peptaibols from Sepedonium ampullosporum Damon KSH 534 Exhibit Promising Antifungal and Anticancer Activity." International Journal of Molecular Sciences 22, no. 23 (2021): 12718. http://dx.doi.org/10.3390/ijms222312718.

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Fungal species of genus Sepedonium are rich sources of diverse secondary metabolites (e.g., alkaloids, peptaibols), which exhibit variable biological activities. Herein, two new peptaibols, named ampullosporin F (1) and ampullosporin G (2), together with five known compounds, ampullosporin A (3), peptaibolin (4), chrysosporide (5), c(Trp-Ser) (6) and c(Trp-Ala) (7), have been isolated from the culture of Sepedonium ampullosporum Damon strain KSH534. The structures of 1 and 2 were elucidated based on ESI-HRMSn experiments and intense 1D and 2D NMR analyses. The sequence of ampullosporin F (1) w

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Suherman, Savira Febryanti, and Tangguh Dwi Pramono. "Analisis Risiko Ergonomi Lingkungan Kerja Fisik pada Karyawan Kantor Menggunakan Metode Rapid Office Strain Assessment (ROSA)." Applied Business and Administration Journal 2, no. 3 (2023): 58–68. http://dx.doi.org/10.62201/abaj.v2i3.68.

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The use of computers is now inseparable from office work completion activities. The place where routine business or commerce takes place is the office. Workers are required to spend nearly all of their time operating the computer while seated in front of the monitor due to the computerized system for office work. Long-term computer use combined with improper posture can result in eye fatigue as well as muscle and back injuries and fatigue. Work stances like sitting, composing, and gazing at a PC screen will influence the state of being of representatives. Employee performance will suffer as a

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Felczak, Aleksandra, Katarzyna Zawadzka, Przemysław Bernat, Marta Nowak-Lange, and Katarzyna Lisowska. "Effect of Quinoline on the Phospholipid Profile of Curvularia lunata and Its Microbial Detoxification." Molecules 27, no. 7 (2022): 2081. http://dx.doi.org/10.3390/molecules27072081.

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Quinoline is an N-heterocyclic compound commonly found in wastewater, especially that derived from coal processing, chemical, and pharmaceutical industries. In the present study, the microscopic fungus Curvularia lunata IM 4417, which is known to degrade various xenobiotics, was used. The aim of the research was to study the elimination of quinoline and its influence on fungal phospholipids, which are considered to be excellent indicators of environmental monitoring. Quinoline biodegradation products and phospholipid contents were analyzed using gas chromatography–mass spectrometry and liquid

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Pantoom, Supansa, Larissa Hules, Christopher Schöll та ін. "Mechanistic Insight into the Mode of Action of Acid β-Glucosidase Enhancer Ambroxol". International Journal of Molecular Sciences 23, № 7 (2022): 3536. http://dx.doi.org/10.3390/ijms23073536.

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Ambroxol (ABX) is a mucolytic agent used for the treatment of respiratory diseases. Bioactivity has been demonstrated as an enhancement effect on lysosomal acid β-glucosidase (β-Glu) activity in Gaucher disease (GD). The positive effects observed have been attributed to a mechanism of action similar to pharmacological chaperones (PCs), but an exact mechanistic description is still pending. The current study uses cell culture and in vitro assays to study the effects of ABX on β-Glu activity, processing, and stability upon ligand binding. Structural analogues bromohexine, 4-hydroxybromohexine, a

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Han, Deok-Soo, and Eun-Ok Lee. "Sp1 Plays a Key Role in Vasculogenic Mimicry of Human Prostate Cancer Cells." International Journal of Molecular Sciences 23, no. 3 (2022): 1321. http://dx.doi.org/10.3390/ijms23031321.

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Sp1 transcription factor regulates genes involved in various phenomena of tumor progression. Vasculogenic mimicry (VM) is the alternative neovascularization by aggressive tumor cells. However, there is no evidence of the relationship between Sp1 and VM. This study investigated whether and how Sp1 plays a crucial role in the process of VM in human prostate cancer (PCa) cell lines, PC-3 and DU145. A cell viability assay and three-dimensional culture VM tube formation assay were performed. Protein and mRNA expression levels were detected by Western blot and reverse transcriptase-polymerase chain

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Cheng, Chun-Yuan, Lassina Barro, Shang-Ting Tsai, et al. "Epigallocatechin-3-Gallate-Loaded Liposomes Favor Anti-Inflammation of Microglia Cells and Promote Neuroprotection." International Journal of Molecular Sciences 22, no. 6 (2021): 3037. http://dx.doi.org/10.3390/ijms22063037.

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Microglia-mediated neuroinflammation is recognized to mainly contribute to the progression of neurodegenerative diseases. Epigallocatechin-3-gallate (EGCG), known as a natural antioxidant in green tea, can inhibit microglia-mediated inflammation and protect neurons but has disadvantages such as high instability and low bioavailability. We developed an EGCG liposomal formulation to improve its bioavailability and evaluated the neuroprotective activity in in vitro and in vivo neuroinflammation models. EGCG-loaded liposomes have been prepared from phosphatidylcholine (PC) or phosphatidylserine (P

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Xu, Ya-Ming, E. M. Kithsiri Wijeratne, Manping X. Liu, Lijiang Xuan, Wenqiong Wang, and A. A. Leslie Gunatilaka. "Production and Structural Diversification of Withanolides by Aeroponic Cultivation of Plants of Solanaceae: Cytotoxic and Other Withanolides from Aeroponically Grown Physalis coztomatl." Molecules 27, no. 3 (2022): 909. http://dx.doi.org/10.3390/molecules27030909.

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Withanolides constitute one of the most interesting classes of natural products due to their diversity of structures and biological activities. Our recent studies on withanolides obtained from plants of Solanaceae including Withania somnifera and a number of Physalis species grown under environmentally controlled aeroponic conditions suggested that this technique is a convenient, reproducible, and superior method for their production and structural diversification. Investigation of aeroponically grown Physalis coztomatl afforded 29 withanolides compared to a total of 13 obtained previously fro

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Schwappacher, Raphaela, Walburga Dieterich, Dejan Reljic, et al. "Muscle-Derived Cytokines Reduce Growth, Viability and Migratory Activity of Pancreatic Cancer Cells." Cancers 13, no. 15 (2021): 3820. http://dx.doi.org/10.3390/cancers13153820.

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The evidence that regular physical exercise reduces the risk of developing cancer is well described. However, the interaction between physical exercise and cancer is not fully clarified yet. Several myokines released by skeletal muscle appear to have a direct anti-tumour function. There are few data on myokine secretion after exercise in patients with advanced tumours. Pancreatic cancer (PC) is a very aggressive and usually fatal cancer. To investigate the effects of exercise in PC, the blood of advanced-stage PC patients was analysed after 12 weeks of resistance training using whole-body elec

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Istadi, Aji, Inna Navarro, Silvia Lombardi, et al. "Abstract 3819: Modeling T cell and cancer cell interactions to examine immune checkpoint inhibition resistance in pancreatic cancer." Cancer Research 85, no. 8_Supplement_1 (2025): 3819. https://doi.org/10.1158/1538-7445.am2025-3819.

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Abstract Pancreatic cancer (PC) is a lethal cancer, with ∼90% of patients dying within 5 years. This dire statistic underscores the limitations of current treatments and the need for improved therapeutic approaches. Immune checkpoint inhibition (ICI) has shown promise in promoting long-term progression-free survival across various cancers by reactivating a patients’ latent anti-cancer immune response. However, PC is almost completely resistant to ICI, highlighting the incomplete understanding of immune-cancer interactions in this disease. The tumor microenvironment is a key factor in immunothe

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Walbert, Tobias, Vinay K. Puduvalli, Martin J. B. Taphoorn, Andrew R. Taylor, and Rakesh Jalali. "International patterns of palliative care in neuro-oncology: a survey of physician members of the Asian Society for Neuro-Oncology, the European Association of Neuro-Oncology, and the Society for Neuro-Oncology." Neuro-Oncology Practice 2, no. 2 (2015): 62–69. http://dx.doi.org/10.1093/nop/npu037.

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Abstract Background Brain tumor patients have limited survival and suffer from high morbidity requiring specific symptom management. Specialized palliative care (PC) services have been developed to address these symptoms and provide end-of-life treatment. Global utilization patterns of PC in neuro-oncology are unknown. Methods In a collaborative effort between the Society for Neuro-Oncology (SNO), the European Association of Neuro-Oncology (EANO), and the Asian Society for Neuro-Oncology (ASNO), a 22-question survey was distributed. Wilcoxon 2-sample and Kruskal-Wallis tests were used to asses

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Piovan, Anna, Raffaella Filippini, Carla Argentini, Stefano Moro, Pietro Giusti, and Morena Zusso. "The Effect of C-Phycocyanin on Microglia Activation Is Mediated by Toll-like Receptor 4." International Journal of Molecular Sciences 23, no. 3 (2022): 1440. http://dx.doi.org/10.3390/ijms23031440.

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The blue-green alga Spirulina platensis is rich in phycocyanins, that exhibit a wide range of pharmacological actions. C-phycocyanin (C-PC), in particular, possesses hepatoprotective, nephroprotective, antioxidant, and anticancer effects. Furthermore, several studies have reported both anti- and proinflammatory properties of this pigment. However, the precise mechanism(s) of action of C-PC in these processes remain largely unknown. Therefore, here we explored the C-PC effect in in vitro microglia activation. The effect of C-PC on the expression and release of IL-1β and TNF-α and the activation

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Lin, Hsiao-Chien, and Jin-Yuarn Lin. "Pharmacological Effects of Guava (Psidium guajava L.) Seed Polysaccharides: GSF3 Inhibits PC-3 Prostate Cancer Cell Growth through Immunotherapy In Vitro." International Journal of Molecular Sciences 22, no. 7 (2021): 3631. http://dx.doi.org/10.3390/ijms22073631.

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The inhibitory effects of purified fractions isolated from guava seed polysaccharides (GSPS) including guava seed polysaccharide fraction 1 (GSF1), GSF2, and GSF3 on prostate cancer cells remain unclear. To clarify the anti-prostate cancer potential, GSPS, GSF1, GSF2, and GSF3 were isolated using Sepharose 6B gel filtration chromatography to assay their inhibitory effects on prostate PC-3 cell growth with direct action or indirect immunotherapy using either splenocyte conditioned media (SCM) or macrophage conditioned media (MCM). Correlations between cytokine profiles in the conditioned media

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Palicelli, Andrea, Stefania Croci, Alessandra Bisagni, et al. "What Do We Have to Know about PD-L1 Expression in Prostate Cancer? A Systematic Literature Review. Part 4: Experimental Treatments in Pre-Clinical Studies (Cell Lines and Mouse Models)." International Journal of Molecular Sciences 22, no. 22 (2021): 12297. http://dx.doi.org/10.3390/ijms222212297.

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In prostate cancer (PC), the PD-1/PD-L1 axis regulates various signaling pathways and it is influenced by extracellular factors. Pre-clinical experimental studies investigating the effects of various treatments (alone or combined) may discover how to overcome the immunotherapy-resistance in PC-patients. We performed a systematic literature review (PRISMA guidelines) to delineate the landscape of pre-clinical studies (including cell lines and mouse models) that tested treatments with effects on PD-L1 signaling in PC. NF-kB, MEK, JAK, or STAT inhibitors on human/mouse, primary/metastatic PC-cell

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Horinokita, Ichiro, Hideki Hayashi, Takamasa Nagatomo, Yuna Fushiki, Yui Iwatani, and Norio Takagi. "Effect of Progranulin on Proliferation and Differentiation of Neural Stem/Progenitor Cells after Oxygen/Glucose Deprivation." International Journal of Molecular Sciences 23, no. 4 (2022): 1949. http://dx.doi.org/10.3390/ijms23041949.

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We previously demonstrated that sivelestat, a selective neutrophil elastase inhibitor, attenuates the cleavage of progranulin (PGRN) and ischemia-induced cell injury in the brain. To obtain further insight into the role of PGRN, in the present study we evaluated the direct effects of sivelestat and recombinant PGRN (rPGRN) on the proliferation and differentiation of neural stem cells in cultures of neural stem/progenitor cells (NS/PC) under the ischemic condition in vitro. We demonstrated that oxygen/glucose deprivation (OGD)-induced cell proliferation of NS/PC was increased by rPGRN treatment

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Gehmeyr, Julian, Abdelouahid Maghnouj, Jonas Tjaden, et al. "Disabling VEGF-Response of Purkinje Cells by Downregulation of KDR via miRNA-204-5p." International Journal of Molecular Sciences 22, no. 4 (2021): 2173. http://dx.doi.org/10.3390/ijms22042173.

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The vascular endothelial growth factor (VEGF) is well known for its wide-ranging functions, not only in the vascular system, but also in the central (CNS) and peripheral nervous system (PNS). To study the role of VEGF in neuronal protection, growth and maturation processes have recently attracted much interest. These effects are mainly mediated by VEGF receptor 2 (VEGFR-2). Current studies have shown the age-dependent expression of VEGFR-2 in Purkinje cells (PC), promoting dendritogenesis in neonatal, but not in mature stages. We hypothesize that microRNAs (miRNA/miR) might be involved in the

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Petrić, Tina, and Maja Sabol. "Let’s Go 3D! New Generation of Models for Evaluating Drug Response and Resistance in Prostate Cancer." International Journal of Molecular Sciences 24, no. 6 (2023): 5293. http://dx.doi.org/10.3390/ijms24065293.

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Prostate cancer (PC) is the third most frequently diagnosed cancer worldwide and the second most frequent in men. Several risk factors can contribute to the development of PC, and those include age, family history, and specific genetic mutations. So far, drug testing in PC, as well as in cancer research in general, has been performed on 2D cell cultures. This is mainly because of the vast benefits these models provide, including simplicity and cost effectiveness. However, it is now known that these models are exposed to much higher stiffness; lose physiological extracellular matrix on artifici

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Carmona, Andres, Fatima Guerrero, Juan R. Muñoz-Castañeda, et al. "Uremic Toxins Induce THP-1 Monocyte Endothelial Adhesion and Migration through Specific miRNA Expression." International Journal of Molecular Sciences 24, no. 16 (2023): 12938. http://dx.doi.org/10.3390/ijms241612938.

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Atherosclerosis is initiated by the activation of endothelial cells that allows monocyte adhesion and transmigration through the vascular wall. The accumulation of uremic toxins such as indoxyl sulphate (IS) and p-cresol (PC) has been associated with atherosclerosis. Currently, miRNAs play a crucial role in the regulation of monocyte activation, adhesion, and trans-endothelial migration. The aim of the present study is to evaluate the effect of IS and PC on monocyte adhesion and migration processes in monocytes co-cultured with endothelial cells as well as to determine the underlying mechanism

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Carastro, L. Michael, Ethan J. Vallebuona, Ricardo Cordova, et al. "Polyphenon E Effects on Gene Expression in PC-3 Prostate Cancer Cells." International Journal of Molecular Sciences 23, no. 22 (2022): 14328. http://dx.doi.org/10.3390/ijms232214328.

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Polyphenon E (Poly E) is a standardized, caffeine-free green tea extract with defined polyphenol content. Poly E is reported to confer chemoprotective activity against prostate cancer (PCa) progression in the TRAMP model of human PCa, and has shown limited activity against human PCa in human trials. The molecular mechanisms of the observed Poly E chemopreventive activity against PCa are not fully understood. We hypothesized that Poly E treatment of PCa cells induces gene expression changes, which could underpin the molecular mechanisms of the limited Poly E chemoprevention activity against PCa

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Picado-Arce, Karol, Stefani Matarrita-Muñoz, Olmer Núñez-Sosa, and Magaly Zúñiga-Céspedes. "Drivers for the development of computational thinking in Costa Rican students." Comunicar 29, no. 68 (2021): 85–96. http://dx.doi.org/10.3916/c68-2021-07.

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This study provides evidence about factors that facilitate the development of computational thinking (CT) in Costa Rican elementary school students, including the description of the contribution of the LIE++ proposal that addresses CT knowledge and practices through programming and physical computing projects. A quasi-experimental design was used to compare a group of students from the LIE++ educational proposal with a group of students from another proposal called LIE-Guides, which emphasizes learning with digital technologies. The study sample comprised 14,795 voluntary students, who answere

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Neuhaus, Jochen, Annett Weimann, and Mandy Berndt-Paetz. "Immunocytochemical Analysis of Endogenous Frizzled-(Co-)Receptor Interactions and Rapid Wnt Pathway Activation in Mammalian Cells." International Journal of Molecular Sciences 22, no. 21 (2021): 12057. http://dx.doi.org/10.3390/ijms222112057.

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The differential activation of Wnt pathways (canonical: Wnt/β-catenin; non-canonical: planar cell polarity (PCP), Wnt/Ca2+) depends on the cell-specific availability and regulation of Wnt receptors, called Frizzled (FZD). FZDs selectively recruit co-receptors to activate various downstream effectors. We established a proximity ligation assay (PLA) for the detection of endogenous FZD–co-receptor interactions and analyzed time-dependent Wnt pathway activation in cultured cells. Prostate cancer cells (PC-3) stimulated by Wnt ligands (Wnt5A, Wnt10B) were analyzed by Cy3-PLA for the co-localization

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Zhu, Na, Yong Li, and Meihong Xu. "Beneficial Effects of Small-Molecule Oligopeptides Isolated from Panax Ginseng C. A. Meyer on Cellular Fates in Oxidative Stress-Induced Damaged Human Umbilical Vein Endothelial Cells and PC-12." International Journal of Molecular Sciences 25, no. 5 (2024): 2906. http://dx.doi.org/10.3390/ijms25052906.

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Cell fate instability is a crucial characteristic of aging and appears to contribute to various age-related pathologies. Exploring the connection between bioactive substances and cell fate stability may offer valuable insights into longevity. Therefore, the objective of this study was to investigate the potential beneficial effects of ginseng oligopeptides (GOPs) isolated from Panax ginseng C. A. Meyer at the cellular level. Disruption of homeostasis of human umbilical vein endothelial cells (HUVECs) and PC-12 was achieved by culturing them in the growth medium supplemented with 200 µM of H2O2

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