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Journal articles on the topic 'Physical Properties of W. Somnifera'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Gaurav, Harshita, Divyanshu Yadav, Ankita Maurya, et al. "Biodiversity, Biochemical Profiling, and Pharmaco-Commercial Applications of Withania somnifera: A Review." Molecules 28, no. 3 (2023): 1208. http://dx.doi.org/10.3390/molecules28031208.

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Withania somnifera L. Dunal (Ashwagandha), a key medicinal plant native to India, is used globally to manage various ailments. This review focuses on the traditional uses, botany, phytochemistry, and pharmacological advances of its plant-derived constituents. It has been reported that at least 62 crucial and 48 inferior primary and secondary metabolites are present in the W. somnifera leaves, and 29 among these found in its roots and leaves are chiefly steroidal compounds, steroidal lactones, alkaloids, amino acids, etc. In addition, the whole shrub parts possess various medicinal activities s

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2

Pandey, Umesh Chandra, Karunakar Shukla, and Rakesh Kumar Jatav. "Pharmacognostical, Phytochemical Screening and Evaluation of Anxiolytic activity of Alcoholic Extract of Withania somnifera (L) Dunal Roots." Journal of Drug Delivery and Therapeutics 13, no. 5 (2023): 29–34. http://dx.doi.org/10.22270/jddt.v13i5.5806.

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The roots of Withania somnifera (L) Dunal (W. somnifera) are used extensively in Ayurveda, the classical Indian system of medicine, and W. somnifera is categorized as a rasayana, which are used to promote physical and mental health, to provide defense against disease and adverse environmental factors and to arrest the aging process. W. somnifera has been used to stabilize mood in patients with behavioural disturbances. The objective of this study was to investigate pharmacognostical, phytochemical features and anxiolytic activity of alcoholic extracts of W. somnifera roots. The various pharmac

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3

Nykvist, Cathryn Dawn, Mahendra Kumar Trivedi, Gopal Nayak, Alice Branton, and Dahryn Trivedi. "A Comprehensive Physical, Spectroscopic, and Thermal Characterization of Withania somnifera (Ashwagandha) Root Extract Treated with the Energy of Consciousness (The Trivedi Effect®)." International Journal of Biomedical Materials Research 5, no. 1 (2017): 5–14. https://doi.org/10.5281/zenodo.822549.

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Withania somnifera (Ashwagandha) root extract possesses a broad range of pharmacological activities. The aim of current study was to explore the impact of The Trivedi Effect® - Energy of Consciousness Healing Treatment (Biofield Energy Healing Treatment) on the physical, spectroscopic, and thermal properties of ashwagandha root extract using PXRD, PSD, FT-IR, UV-vis spectroscopy, TGA, and DSC analysis. Ashwagandha root extract was divided into two parts. One part was denoted as the control, while the other part was defined as The Trivedi Effect® - Biofield Energy Treated sample, which received

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4

Vincent, Dianne Heather, Mahendra Kumar Trivedi, Gopal Nayak, Alice Branton, and Dahryn Trivedi. "A Comprehensive Physical, Spectroscopic, and Thermal Characterization of Withania somnifera (Ashwagandha) Root Extract Treated with the Energy of Consciousness (The Trivedi Effect®)." International Journal of Biomedical Materials Research 5, no. 1 (2017): 5–14. https://doi.org/10.5281/zenodo.834415.

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Withania somnifera (Ashwagandha) root extract possesses a broad range of pharmacological activities. The aim of current study was to explore the impact of The Trivedi Effect® - Energy of Consciousness Healing Treatment (Biofield Energy Healing Treatment) on the physical, spectroscopic, and thermal properties of ashwagandha root extract using PXRD, PSD, FT-IR, UV-vis spectroscopy, TGA, and DSC analysis. Ashwagandha root extract was divided into two parts. One part was denoted as the control, while the other part was defined as The Trivedi Effect® - Biofield Energy Treated sample, which received

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5

Konersman, Douglas Jay, Mahendra Kumar Trivedi, Gopal Nayak, Alice Branton, and Dahryn Trivedi. "A Comprehensive Physical, Spectroscopic, and Thermal Characterization of Withania somnifera (Ashwagandha) Root Extract Treated with the Energy of Consciousness (The Trivedi Effect®)." International Journal of Biomedical Materials Research 5, no. 1 (2017): 5–14. https://doi.org/10.5281/zenodo.835640.

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Withania somnifera (Ashwagandha) root extract possesses a broad range of pharmacological activities. The aim of current study was to explore the impact of The Trivedi Effect® - Energy of Consciousness Healing Treatment (Biofield Energy Healing Treatment) on the physical, spectroscopic, and thermal properties of ashwagandha root extract using PXRD, PSD, FT-IR, UV-vis spectroscopy, TGA, and DSC analysis. Ashwagandha root extract was divided into two parts. One part was denoted as the control, while the other part was defined as The Trivedi Effect® - Biofield Energy Treated sample, which received

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6

Feeney, Elizabeth Ann, Mahendra Kumar Trivedi, Gopal Nayak, Alice Branton, and Dahryn Trivedi. "A Comprehensive Physical, Spectroscopic, and Thermal Characterization of Withania somnifera (Ashwagandha) Root Extract Treated with the Energy of Consciousness (The Trivedi Effect®)." International Journal of Biomedical Materials Research 5, no. 1 (2017): 5–14. https://doi.org/10.5281/zenodo.836593.

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Withania somnifera (Ashwagandha) root extract possesses a broad range of pharmacological activities. The aim of current study was to explore the impact of The Trivedi Effect® - Energy of Consciousness Healing Treatment (Biofield Energy Healing Treatment) on the physical, spectroscopic, and thermal properties of ashwagandha root extract using PXRD, PSD, FT-IR, UV-vis spectroscopy, TGA, and DSC analysis. Ashwagandha root extract was divided into two parts. One part was denoted as the control, while the other part was defined as The Trivedi Effect® - Biofield Energy Treated sample, which received

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7

Prague, Jay Anthony, Mahendra Kumar Trivedi, Gopal Nayak, Alice Branton, and Dahryn Trivedi. "A Comprehensive Physical, Spectroscopic, and Thermal Characterization of Withania somnifera (Ashwagandha) Root Extract Treated with the Energy of Consciousness (The Trivedi Effect®)." International Journal of Biomedical Materials Research 5, no. 1 (2017): 5–14. https://doi.org/10.5281/zenodo.838384.

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Withania somnifera (Ashwagandha) root extract possesses a broad range of pharmacological activities. The aim of current study was to explore the impact of The Trivedi Effect® - Energy of Consciousness Healing Treatment (Biofield Energy Healing Treatment) on the physical, spectroscopic, and thermal properties of ashwagandha root extract using PXRD, PSD, FT-IR, UV-vis spectroscopy, TGA, and DSC analysis. Ashwagandha root extract was divided into two parts. One part was denoted as the control, while the other part was defined as The Trivedi Effect® - Biofield Energy Treated sample, which received

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8

Starodub, Joanne Lydia, Mahendra Kumar Trivedi, Gopal Nayak, Alice Branton, and Dahryn Trivedi. "A Comprehensive Physical, Spectroscopic, and Thermal Characterization of Withania somnifera (Ashwagandha) Root Extract Treated with the Energy of Consciousness (The Trivedi Effect®)." International Journal of Biomedical Materials Research 5, no. 1 (2017): 5–14. https://doi.org/10.5281/zenodo.839093.

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Withania somnifera (Ashwagandha) root extract possesses a broad range of pharmacological activities. The aim of current study was to explore the impact of The Trivedi Effect® - Energy of Consciousness Healing Treatment (Biofield Energy Healing Treatment) on the physical, spectroscopic, and thermal properties of ashwagandha root extract using PXRD, PSD, FT-IR, UV-vis spectroscopy, TGA, and DSC analysis. Ashwagandha root extract was divided into two parts. One part was denoted as the control, while the other part was defined as The Trivedi Effect® - Biofield Energy Treated sample, which received

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9

Rasdan, Karan, Mahendra Kumar Trivedi, Gopal Nayak, Alice Branton, and Dahryn Trivedi. "A Comprehensive Physical, Spectroscopic, and Thermal Characterization of Withania somnifera (Ashwagandha) Root Extract Treated with the Energy of Consciousness (The Trivedi Effect®)." International Journal of Biomedical Materials Research 5, no. 1 (2017): 5–14. https://doi.org/10.5281/zenodo.840618.

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Withania somnifera (Ashwagandha) root extract possesses a broad range of pharmacological activities. The aim of current study was to explore the impact of The Trivedi Effect® - Energy of Consciousness Healing Treatment (Biofield Energy Healing Treatment) on the physical, spectroscopic, and thermal properties of ashwagandha root extract using PXRD, PSD, FT-IR, UV-vis spectroscopy, TGA, and DSC analysis. Ashwagandha root extract was divided into two parts. One part was denoted as the control, while the other part was defined as The Trivedi Effect® - Biofield Energy Treated sample, which received

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10

Mayne, Maire Anne, Mahendra Kumar Trivedi, Gopal Nayak, Alice Branton, and Dahryn Trivedi. "A Comprehensive Physical, Spectroscopic, and Thermal Characterization of Withania somnifera (Ashwagandha) Root Extract Treated with the Energy of Consciousness (The Trivedi Effect®)." International Journal of Biomedical Materials Research 5, no. 1 (2017): 5–14. https://doi.org/10.5281/zenodo.843623.

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Withania somnifera (Ashwagandha) root extract possesses a broad range of pharmacological activities. The aim of current study was to explore the impact of The Trivedi Effect® - Energy of Consciousness Healing Treatment (Biofield Energy Healing Treatment) on the physical, spectroscopic, and thermal properties of ashwagandha root extract using PXRD, PSD, FT-IR, UV-vis spectroscopy, TGA, and DSC analysis. Ashwagandha root extract was divided into two parts. One part was denoted as the control, while the other part was defined as The Trivedi Effect® - Biofield Energy Treated sample, which received

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11

Sodomora, Sharyn Marie, Mahendra Kumar Trivedi, Gopal Nayak, Alice Branton, and Dahryn Trivedi. "A Comprehensive Physical, Spectroscopic, and Thermal Characterization of Withania somnifera (Ashwagandha) Root Extract Treated with the Energy of Consciousness (The Trivedi Effect®)." International Journal of Biomedical Materials Research 5, no. 1 (2017): 5–14. https://doi.org/10.5281/zenodo.852382.

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Withania somnifera (Ashwagandha) root extract possesses a broad range of pharmacological activities. The aim of current study was to explore the impact of The Trivedi Effect® - Energy of Consciousness Healing Treatment (Biofield Energy Healing Treatment) on the physical, spectroscopic, and thermal properties of ashwagandha root extract using PXRD, PSD, FT-IR, UV-vis spectroscopy, TGA, and DSC analysis. Ashwagandha root extract was divided into two parts. One part was denoted as the control, while the other part was defined as The Trivedi Effect® - Biofield Energy Treated sample, which received

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12

Strassman, Karen Mie, Mahendra Kumar Trivedi, Gopal Nayak, Alice Branton, and Dahryn Trivedi. "A Comprehensive Physical, Spectroscopic, and Thermal Characterization of Withania somnifera (Ashwagandha) Root Extract Treated with the Energy of Consciousness (The Trivedi Effect®)." International Journal of Biomedical Materials Research 5, no. 1 (2017): 5–14. https://doi.org/10.5281/zenodo.841401.

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Withania somnifera (Ashwagandha) root extract possesses a broad range of pharmacological activities. The aim of current study was to explore the impact of The Trivedi Effect® - Energy of Consciousness Healing Treatment (Biofield Energy Healing Treatment) on the physical, spectroscopic, and thermal properties of ashwagandha root extract using PXRD, PSD, FT-IR, UV-vis spectroscopy, TGA, and DSC analysis. Ashwagandha root extract was divided into two parts. One part was denoted as the control, while the other part was defined as The Trivedi Effect® - Biofield Energy Treated sample, which received

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13

Keesee, Mary M., Mahendra Kumar Trivedi, Gopal Nayak, Alice Branton, and Dahryn Trivedi. "A Comprehensive Physical, Spectroscopic, and Thermal Characterization of Withania somnifera (Ashwagandha) Root Extract Treated with the Energy of Consciousness (The Trivedi Effect®)." International Journal of Biomedical Materials Research 5, no. 1 (2017): 5–14. https://doi.org/10.5281/zenodo.845038.

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Withania somnifera (Ashwagandha) root extract possesses a broad range of pharmacological activities. The aim of current study was to explore the impact of The Trivedi Effect® - Energy of Consciousness Healing Treatment (Biofield Energy Healing Treatment) on the physical, spectroscopic, and thermal properties of ashwagandha root extract using PXRD, PSD, FT-IR, UV-vis spectroscopy, TGA, and DSC analysis. Ashwagandha root extract was divided into two parts. One part was denoted as the control, while the other part was defined as The Trivedi Effect® - Biofield Energy Treated sample, which received

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14

Ansley, Pamela Clarkson, Mahendra Kumar Trivedi, Gopal Nayak, Alice Branton, and Dahryn Trivedi. "A Comprehensive Physical, Spectroscopic, and Thermal Characterization of Withania somnifera (Ashwagandha) Root Extract Treated with the Energy of Consciousness (The Trivedi Effect®)." International Journal of Biomedical Materials Research 5, no. 1 (2017): 5–14. https://doi.org/10.5281/zenodo.845545.

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Withania somnifera (Ashwagandha) root extract possesses a broad range of pharmacological activities. The aim of current study was to explore the impact of The Trivedi Effect® - Energy of Consciousness Healing Treatment (Biofield Energy Healing Treatment) on the physical, spectroscopic, and thermal properties of ashwagandha root extract using PXRD, PSD, FT-IR, UV-vis spectroscopy, TGA, and DSC analysis. Ashwagandha root extract was divided into two parts. One part was denoted as the control, while the other part was defined as The Trivedi Effect® - Biofield Energy Treated sample, which received

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15

Schmitz, Ronald David, Mahendra Kumar Trivedi, Gopal Nayak, Alice Branton, and Dahryn Trivedi. "A Comprehensive Physical, Spectroscopic, and Thermal Characterization of Withania somnifera (Ashwagandha) Root Extract Treated with the Energy of Consciousness (The Trivedi Effect®)." International Journal of Biomedical Materials Research 5, no. 1 (2017): 5–14. https://doi.org/10.5281/zenodo.848491.

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Withania somnifera (Ashwagandha) root extract possesses a broad range of pharmacological activities. The aim of current study was to explore the impact of The Trivedi Effect® - Energy of Consciousness Healing Treatment (Biofield Energy Healing Treatment) on the physical, spectroscopic, and thermal properties of ashwagandha root extract using PXRD, PSD, FT-IR, UV-vis spectroscopy, TGA, and DSC analysis. Ashwagandha root extract was divided into two parts. One part was denoted as the control, while the other part was defined as The Trivedi Effect® - Biofield Energy Treated sample, which received

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16

Deshpande, Sanjay H., Abdullatif Bin Muhsinah, Zabin K. Bagewadi, et al. "In Silico Study on the Interactions, Molecular Docking, Dynamics and Simulation of Potential Compounds from Withania somnifera (L.) Dunal Root against Cancer by Targeting KAT6A." Molecules 28, no. 3 (2023): 1117. http://dx.doi.org/10.3390/molecules28031117.

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Cancer is characterized by the abnormal development of cells that divide in an uncontrolled manner and further take over the body and destroy the normal cells of the body. Although several therapies are practiced, the demand and need for new therapeutic agents are ever-increasing because of issues with the safety, efficacy and efficiency of old drugs. Several plant-based therapeutics are being used for treatment, either as conjugates with existing drugs or as standalone formulations. Withania somnifera (L.) Dunal is a highly studied medicinal plant which is known to possess immunomodulatory ac

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17

Venkatachalapathy, Deepthi, Chandan Shivamallu, Shashanka K. Prasad, et al. "Assessment of Chemopreventive Potential of the Plant Extracts against Liver Cancer Using HepG2 Cell Line." Molecules 26, no. 15 (2021): 4593. http://dx.doi.org/10.3390/molecules26154593.

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The edible parts of the plants Camellia sinensis, Vitis vinifera and Withania somnifera were extensively used in ancient practices such as Ayurveda, owing to their potent biomedical significance. They are very rich in secondary metabolites such as polyphenols, which are very good antioxidants and exhibit anti-carcinogenic properties. This study aims to evaluate the anti-cancerous properties of these plant crude extracts on human liver cancer HepG2 cells. The leaves of Camellia sinensis, Withania somnifera and the seeds of Vitis vinifera were collected and methanolic extracts were prepared. The

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18

Wiciński, Michał, Anna Fajkiel-Madajczyk, Zuzanna Kurant, et al. "Can Ashwagandha Benefit the Endocrine System?—A Review." International Journal of Molecular Sciences 24, no. 22 (2023): 16513. http://dx.doi.org/10.3390/ijms242216513.

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Withania somnifera, also known as Ashwagandha, has been used in traditional medicine for thousands of years. Due to the wide range of its activities, there has been interest in its possible beneficial effects on the human body. It is proved that, among others, Ashwagandha has anti-stress, anti-inflammatory, antimicrobial, anti-cancer, anti-diabetic, anti-obesity, cardioprotective, and hypolipidemic properties. Particularly interesting are its properties reported in the field of psychiatry and neurology: in Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, depression, bipolar disord

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Jamalludin, Nurul Bariah, and Nurhuda Manshoor. "Ethnobotanical importance, phytochemical constituents, and pharmacological properties of Withania somnifera." Journal of Herbmed Pharmacology 11, no. 3 (2022): 320–29. http://dx.doi.org/10.34172/jhp.2022.37.

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Withania somnifera belongs to the family of Solanaceae. It is widely used by the locals, especially in India, as a medicinal plant. W. somnifera is rich in alkaloid and steroidal lactone that account for various pharmacological activities. The present study aimed to review all the evidence on the ethnobotanical perspective of W. somnifera in some countries. This review also analyses the bioactive compounds that account for the pharmacological activities. The online medical literature databases such as ScienceDirect, PubMed, and Google Scholar were used to search articles up to March 2022. W. s

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Adhikari, Lokesh, Rupali Kotiyal, Mukesh Pandey, Meenakshi Bharkatiya, Ajay Sematy, and Mona Semalty. "Effect of Geographical Location and Type of Extract on Total Phenol/Flavon Contents and Antioxidant Activity of Different Fruits Extracts of Withania somnifera." Current Drug Discovery Technologies 17, no. 1 (2020): 92–99. http://dx.doi.org/10.2174/1570163815666180807100456.

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Background:Withania somnifera (family solanaceae) is a well-investigated medicinal plant which is also called Indian ginseng due to its wide spectrum of medicinal properties. The contents and activity of the plant may vary depending on the habitat and part of the plant and the solvent used for extraction. The present study deals with the comparative chemical analysis and in vitro antioxidant activity of methanolic fruits extracts and its subfractions (in ethyl acetate, butanol and water) of W. somnifera collected from two different geographical locations.Methods:In the present study, Withania

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21

Hammood, Mahmood Neamah, Liqaa Hasson Saqban, and Nazar Jebar Metib. "Protective Role of Withania somnifera Against the Adverse Effects of Levofloxacin on Testes Tissue of Rats In Vivo." Medical Journal of Babylon 22, no. 1 (2025): 41–49. https://doi.org/10.4103/mjbl.mjbl_174_23.

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Abstract Background: Medicinal plants have many uses in traditional medicine in all cultures due to their unique therapeutic properties. Withania somnifera is considered an agent to improve sexual health, an antioxidant, anti-aging, and anti-inflammatory. Objective: This study aimed to determine the therapeutic effect of W. somnifera on the potential Levofloxacin-induced testicular injury in rats. Materials and Methods: Thirty adult male Wistar rats were randomly divided into five groups: control group (C), saline-treated for 60 days. Group (W) W. somnifera root extract was orally treated for

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22

R, Kundra, S. S. Samant, SK Nandi, and RK Sharma. "Investigation of antioxidant properties of Withania somnifera (L.) Dunal and influence of physico-chemical properties of soil along the topographic gradients in sub-tropical region of the Indian Himalaya." International Journal of Phytomedicine 9, no. 3 (2017): 407. http://dx.doi.org/10.5138/09750185.1986.

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<p>A high value medicinal plant <em>W. somnifera </em>L. Indian Ginseng; Ashwagandha investigated for the antioxidant and influence of physico-chemical properties of soil on antioxidant along the topographical gradients in Kullu Valley, North Western Indian Himalaya. Total phenolic and flavonoid contents in methanol extracts of fruits, leaves, stems and roots were quantified and their antioxidant activities were evaluated using the <em>in-vitro</em> assays such as DPPH, ABTS and FRAP. The study revealed that fruits, leaves, stems and roots of <em>W. somnifer

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23

Kumar, Ravi, Rajat Dhariwal, Anurag Kumar, and Miss Minata. "Effect of Withania Somnifera (L.) root extract\'s on PC12 induced by hydrogen peroxide, study." Journal of Pharmaceutical and Biological Sciences 10, no. 2 (2023): 79–82. http://dx.doi.org/10.18231/j.jpbs.2022.015.

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The L. is also used as a crude medicament that mostly effected in various neurological and immunological disorders. It is also known as Ashwagandha and “Indian ginseng” in Indian region. There is a lack of information on the possible neuroprotective properties of W. somnifera root against HO- and Ab(1-42)-induced cytotoxicity, which are now targeted for innovative treatments for dementia, particularly dementia of the Alzheimer's type (AD). According to this research, we prepared an aqueous extract of dried roots of W. somnifera that possess the protective effect against Ab- aggregated fibril a

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Thakur, Komal, Pankaj Verma, Isha Agrawal, Manish Vyas, and Sanjeev Kumar Sahu. "In-silico molecular docking for Potential herbal leads from Withaniasomnifera L. Dunal for the treatment of Alzheimer’s disease." BIO Web of Conferences 86 (2024): 01043. http://dx.doi.org/10.1051/bioconf/20248601043.

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Alzheimer's disease (AD) poses a significant global health challenge, necessitating novel therapeutic interventions. Withaniasomnifera L. Dunal, commonly known as Ashwagandha, has been historically utilized in traditional medicine for its neuroprotective properties. This study employs computational techniques to explore the potential of W. somnifera compounds in targeting key proteins associated with AD. The reported phytoconstituents of W. somnifera were identified and subjected to molecular docking studies against 5NUU (Torpedo californica acetylcholinesterase in complex with a chlorotacrine

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Nagappan, Arulkumar, Nithya Karunanithi, Sundareswaran Sentrayaperumal, et al. "Comparative Root Protein Profiles of Korean Ginseng (Panax ginseng) and Indian Ginseng (Withania somnifera)." American Journal of Chinese Medicine 40, no. 01 (2012): 203–18. http://dx.doi.org/10.1142/s0192415x12500164.

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Ginsenosides and withanolides are the secondary metabolites from Panax ginseng and Withania somnifera, respectively. These compounds have similar biological properties. Two-dimensional electrophoresis (2-DE) analysis was utilized to reveal the protein profile in the roots of both plants, with the aim of clarifying similarly- and differentially-expressed proteins. Total proteins of Korea ginseng (P. ginseng) and Indian ginseng (W. somnifera) roots were separated by 2-DE using a pH 4–7 immobilized pH gradient strip in the first dimension and 12% sodium dodecyl sulfate polyacrylamide gel electrop

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SHUKLA, A., S. SRIVASTAVA, and K. DEV. "Review on chemistry, pharmacology, toxicity and future prospectives of withaferin A." Journal of Medicinal and Aromatic Plant Sciences 45, no. 3 (2023): 108–22. http://dx.doi.org/10.62029/jmaps.v45i3.shukla.

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The medicinal plant Withania somnifera is widely researched for its antiinflammatory,cardioprotective, and anticancer effects. W. somnifera preparations are specifically used to treat menstruation issues and arthritis in Ayurveda, the main traditional Indian medical system. The bioactive substance withaferin A (WA), a steroidal lactone, was first isolated from the leaves of W. somnifera. Numerous studies showed that WA contains various pharmacological properties, making it a good choice for treating various diseases. Its structural modification targets several signal transduction pathways and

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Alsabaa, Zein Husam, Luay Abu-Qatouseh, Kenza Mansoor, et al. "Pharmacokinetic and pharmacodynamic effects of Withania somnifera (L.) Dunal (ashwagandha) and carbamazepine combination in rats." Journal of Pharmacy & Pharmacognosy Research 13, no. 3 (2025): 925–32. https://doi.org/10.56499/jppres24.2088_13.3.925.

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Context: Withania somnifera, also known as ashwagandha, has antibacterial, anti-inflammatory, anticonvulsant, and anti-diabetic properties and reduces stress. Carbamazepine is one of the most used antiepileptic medications for treating epilepsy. Aims: To investigate the pharmacokinetics and pharmacodynamics of carbamazepine versus W. somnifera extract combination in vivo in healthy rat plasma using high-performance liquid chromatography. Methods: The carbamazepine levels were analyzed using validated high-performance liquid chromatography. The gamma-aminobutyric acid in the serum was performed

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Munir, Naveed, Zahed Mahmood, Muhammad Shahid, et al. "Withania somnifera Chemical Constituents’ In Vitro Antioxidant Potential and Their Response on Spermatozoa Parameters." Dose-Response 20, no. 1 (2022): 155932582210749. http://dx.doi.org/10.1177/15593258221074936.

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Background: Phytomedicine is becoming more acceptable as an alternative medicinal approach in the modern era. Objectives: The current study examined the antioxidant capacity and in vitro response of phytochemical constituents of Withania somnifera (Ashwagandha) on standard parameters of healthy volunteer semen. Methods: The phytochemicals and their pharmacological response in a hydroethanolic (30:70 v/v) extract of W. somnifera roots were determined using standard protocols. Results: The constituents included flavonoids, phenolic acids, alkaloids, and terpenoids were reported. High-performance

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Kalpana, Kriti, Shen Yap, Moriya Tsuji, and Akira Kawamura. "Molecular Mechanism behind the Safe Immunostimulatory Effect of Withania somnifera." Biomolecules 13, no. 5 (2023): 828. http://dx.doi.org/10.3390/biom13050828.

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Withania somnifera (L.) Dunal (family Solanaceae) is a medicinal plant known for, among many pharmacological properties, an immune boosting effect. Our recent study revealed that its key immunostimulatory factor is lipopolysaccharide of plant-associated bacteria. This is peculiar, because, although LPS can elicit protective immunity, it is an extremely potent pro-inflammatory toxin (endotoxin). However, W. somnifera is not associated with such toxicity. In fact, despite the presence of LPS, it does not trigger massive inflammatory responses in macrophages. To gain insights into the safe immuno

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LİNGFA, Lali, Aravinda TİRUMALA, and Srinivas ANKANAGARİ. "GC-MS profiling of anticancer and antimicrobial phytochemicals in the vegetative leaf, root, and stem of Withania somnifera (L.) Dunal." International Journal of Secondary Metabolite 11, no. 1 (2023): 63–77. http://dx.doi.org/10.21448/ijsm.1256932.

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Withania somnifera has been used for a long time in traditional medicine. Its crude extract, dried powder, and purified metabolites from mature plants have shown promising therapeutic potential. To further investigate its potential, the detection of phytochemicals with anticancer and antimicrobial properties in the vegetative stage is essential. Hence, this study was done to identify phytochemical constituents using GC-MS analysis for anticancer and antimicrobial activities in the vegetative stage from methanolic extracts of stem, leaf, and root in W. somnifera. The air-dried plant parts were

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Ahmad, Muzamil, Sofiyan Saleem, Abdullah Shafique Ahmad, et al. "Neuroprotective effects of Withania somnifera on 6-hydroxydopamine induced Parkinsonism in rats." Human & Experimental Toxicology 24, no. 3 (2005): 137–47. http://dx.doi.org/10.1191/0960327105ht509oa.

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6-Hydroxydopamine (6-OHDA) is one of the most widely used rat models for Parkinson's disease. There is ample evidence in the literature that 6-OHDA elicits its toxic manifestations through oxidant stress. In the present study, we evaluated the anti-parkinsonian effects of Withania somnifera extract, which has been reported to have potent anti-oxidant, anti-peroxidative and free radical quenching properties in various diseased conditions. Rats were pretreated with 100, 200 and 300 mg/kg b.w. of the W. somnifera extract orally for 3 weeks. On day 21, 2 mL of 6-OHDA (10 mg in 0.1% in ascorbic aci

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Tancreda, Gabriele, Silvia Ravera, and Isabella Panfoli. "Preclinical Evidence of Withania somnifera and Cordyceps spp.: Neuroprotective Properties for the Management of Alzheimer’s Disease." International Journal of Molecular Sciences 26, no. 11 (2025): 5403. https://doi.org/10.3390/ijms26115403.

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Alzheimer’s disease (AD) is considered one of the main pathologies of our time, whose incidence and prevalence are suggested to be strongly underestimated. AD presents as a complex neurodegenerative condition characterized by marked neuroinflammation and a significant decline in the cognitive and mnemonic functions of affected patients. Recognized AD pathological hallmarks include amyloid beta plaque and neurofibrillary tangle formation, synaptic dysfunction with considerable apoptosis of cholinergic and dopaminergic neurons, and high levels of oxidative stress and neuroinflammation. The avail

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Parihar, Pratibha, and Madhumati Bora. "Effect of mycorrhiza (Glomus mosseae) on morphological and biochemical properties of Ashwagandha (Withania somnifera) (L.) Dunal." Journal of Applied and Natural Science 10, no. 4 (2018): 1115–23. http://dx.doi.org/10.31018/jans.v10i4.1797.

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Mycorrhizal inoculation in the plant causing increase in growth and production of phytochemicals is well reported, however little information is available related to the effect of mycorrhiza on morphological and biochemical properties of the medicinal plants like Ashwagandha. The present study is an attempt on diversity analysis in Withania somnifera with an aim to ascertain the nature and extent of genetic diversity present among different accessions in presence of mycorrhiza. The major biochemical constituents of Ashwaganda roots are with nolides which are well known for its medicinal proper

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POTOCKA, Zofia, Aleksandra BORYCKA, Barbara JĘDRZEJEWSKA, et al. "Potential clinical usage of ashwagandha root extract: A review." Journal of Education, Health and Sport 29, no. 1 (2023): 35–44. https://doi.org/10.12775/JEHS.2023.29.01.004.

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<strong>POTOCKA, Zofia, BORYCKA, Aleksandra, JĘDRZEJEWSKA, Barbara, KOTULSKA, Maria, LASKUS, Paulina, LICHMAN, Martyna, LUBCZYŃSKA, Zuzanna, PRZERADZKI, Jakub & RZĄD, Katarzyna. Potential clinical usage of ashwagandha root extract: A review</strong><strong>.</strong> <strong>Journal of Education, Health and Sport. 2023;</strong><strong>29</strong><strong>(1):</strong><strong>35</strong><strong>-</strong><strong>44</strong><strong>. eISSN 2391-8306. DOI </strong><strong>http://dx.doi.org/10.12775/JEHS.2023.29.01.00</strong><strong>4</strong> <strong>https://apcz.umk.pl/JEHS/articl

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Balkrishna, Acharya, Pradeep Nain, Anshul Chauhan та ін. "Super Critical Fluid Extracted Fatty Acids from Withania somnifera Seeds Repair Psoriasis-Like Skin Lesions and Attenuate Pro-Inflammatory Cytokines (TNF-α and IL-6) Release". Biomolecules 10, № 2 (2020): 185. http://dx.doi.org/10.3390/biom10020185.

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(1) Background: Withania somnifera Dunal (Ashwagandha) is a widely used medicinal herb in traditional medicinal systems with extensive research on various plant parts. Surprisingly, seeds of W. somnifera have never been investigated for their therapeutic potential. (2) Methods: W. somnifera seeds were extracted for fatty acids (WSSO) using super critical fluid extraction, and was analyzed by gas chromatography. Its therapeutic potential in psoriasis-like skin etiologies was investigated using a 12-O tetradecanoyl phorbol 13-acetate (TPA)-induced psoriatic mouse model. Psoriatic inflammation al

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Gupta, R., Sanjay Swami, and Z. Banoo. "Effect of soil incubation with organics on rhizosphere and bulk soil properties, root and alkaloid content of Withania somnifera L. Dunal and its performance in Jammu Division." Journal of Environmental Biology 41, no. 6 (2020): 1632–40. http://dx.doi.org/10.22438/jeb/41/6/si-230.

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Aim: To study the effect of soil incubation with organics on rhizosphere and bulk soil properties, biomass and alkaloid content of Withania somnifera as well as plant performance in soil of subtropical and intermediate zones of Jammu division. Methodology: The pot experiment of Withania somnifera consisted of 11 treatments laid in randomized block design in triplicate. Sampling was done at various days of soil incubation with organics viz. 30, 60, 120 and 180. The plant performance was studied at vegetative and seed maturity stages. In field experiment, the plant performance was studied in soi

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Negi, M. S., A. Singh, and M. Lakshmikumaran. "Genetic variation and relationship among and within Withania species as revealed by AFLP markers." Genome 43, no. 6 (2000): 975–80. http://dx.doi.org/10.1139/g00-073.

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Withania somnifera is an important medicinal plant, and its anticancerous properties have been attributed to various classes of withanolide compounds. The objective of the present study was to investigate the inter- and intraspecific genetic variation present in 35 individuals of W. somnifera and 5 individuals of W. coagulans using AFLP (amplified fragment length polymorphism) marker technique. The information about genetic variation determined from AFLP data for 40 individuals was employed to estimate similarity matrix value based on Jaccard's coefficient. The similarity values were further u

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Dubey, Sumit Kumar, Krishan Kumar Verma, Arifa Qureshi, and Neha Behar. "Assessment of Antimicrobial Activity of Commercially available Withania Somnifera (Ashwagandha) Powder against Pathogenic microorganisms." NewBioWorld 4, no. 2 (2023): 25–30. http://dx.doi.org/10.52228/nbw-jaab.2022-4-2-5.

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Withania somnifera L (or Ashwagandha or Indian ginseng) is a sub-tropical medicinal plant of Solanaceae family that is used by folk healers for multipurpose ailments in alternative system of treatment. It serves as bioactive ingredient in more than 100 ayurvedic formulations of Ayurveda, Siddha, and Unani medication. The ethnopharmacological application of Ashwagandha includes adaptogenic, anti-convulsion, anti-microbial anti-sedative, anti-stress, arthritis, geriatric debilities, mental disorders, and neurological disorders. The present study included validation of antimicrobial properties of

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Gomathi Periyasamy, Hima Bindu Kasyap, Bharathi Nayaka, Srikala Rajala, and Prathyusha Segu. "Chemical and pharmacological review of Withania somnifera." World Journal of Biology Pharmacy and Health Sciences 16, no. 2 (2023): 165–72. http://dx.doi.org/10.30574/wjbphs.2023.16.2.0487.

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The Solanaceae family is comprised of 84 genera that include about 3,000 species, scattered throughout the world. Members of this family are generally annual shrubs. The genera Withania and Physalis play an important role in the indigenous medicine of South East Asia, e.g. in the Unani and Ayurvedic systems. Withania somnifera (L.) Dunal, (Solanaceae), commonly known as ashwagandha, winter cherry, Indian ginseng, or poison gooseberry. Traditionally it is commonly used in emaciation of children, hindrance from old age, rheumatism, vitiated conditions of vata, leucoderma, constipation, insomnia,

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K.C., Binita, and Gandhiv Kafle. "Assessment of end products of Ashwagandha (Withania somnifera) and their marketing channel in Bharatpur, Chitwan, Nepal." Journal of Agriculture and Natural Resources 7, no. 1 (2024): 37–49. https://doi.org/10.3126/janr.v7i1.73123.

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This study was conducted for six month from February-July in 2019 to evaluate the end products, end uses, ingredients and marketing channel associated with Ashwagandha (Withania somnifera) in Bharatpur, Chitwan, Nepal. A 100% sampling intensity was employed encompassing all medicinal/herbal retailer shops and processing industries/companies identified within the study area. Data were collected through complete surveys of herbal/medicinal shops and industries located at Bharatpur city by using structured questionnaire which offered 41 end products containing W. somnifera as an ingredient. Addit

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NARGIS, K. M., RAHUL GAUR, AMRAPALI AMRAPALI, KANISHKA KANISHKA, and AJAY SINGH AND CHANDRA KANTA. "Exploring the Antioxidant, Antidiabetic, and Anticancer Potential of Withania somnifera and Withania coagulans: A Comparative Study." JOURNAL OF ENVIRONMENT AND BIO-SCIENCE 38, no. 02 (2024): 377. https://doi.org/10.59467/jebs.2024.38.377.

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Withania somnifera (Ashwagandha) and Withania coagulans (Indian Rennet), two prominent species of the Withania genus (Family: Solanaceae), are well-known for their widespread use in traditional medicine. These plants display various pharmacological properties, including antioxidant, antidiabetic, and anticancer activities. This review compares these pharmacological attributes, aiming at their underlying phytochemical profiles and therapeutic potentials. W. somnifera is rich in withanolides, alkaloids, and flavonoids, contributing to its potent antidiabetic and anticancer effects. Its bioactive

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Gomathi, Periyasamy, Bindu Kasyap Hima, Nayaka Bharathi, Rajala Srikala, and Segu Prathyusha. "Chemical and pharmacological review of Withania somnifera." World Journal of Biology Pharmacy and Health Sciences 16, no. 2 (2023): 165–72. https://doi.org/10.5281/zenodo.10792440.

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<em>The Solanaceae family is comprised of 84 genera that include about 3,000 species, scattered throughout the world. Members of this family are generally annual shrubs. The genera Withania and Physalis play an important role in the indigenous medicine of South East Asia, e.g. in the Unani and Ayurvedic systems. Withania somnifera</em> (L.) Dunal, (Solanaceae), commonly known as ashwagandha, winter cherry, Indian ginseng, or poison gooseberry. Traditionally it is commonly used in emaciation of children, hindrance from old age, rheumatism, vitiated conditions of vata, leucoderma, constipat

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Lingfa, Lali, Aravinda Tirumala, and Srinivas Ankanagari. "In Vitro Cytotoxicity of Reproductive Stage Withania somnifera Leaf and Stem on HepG2 Cell Line." Evidence-Based Complementary and Alternative Medicine 2023 (December 26, 2023): 1–10. http://dx.doi.org/10.1155/2023/8832166.

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Background. The ayurvedic plant Withania somnifera, a member of the Solanaceae family, has been used as a remedy for diverse health problems, including cancer. Objectives. The objective of this investigation was to conduct a comparative analysis of the in vitro cytotoxic properties of methanolic extracts derived from the leaf, stem, and root of W. somnifera on HepG2 and L929 cell lines. Methods. Methanolic extracts were obtained using the Soxhlet extraction method. To assess the in vitro anticancer action on the HepG2 and L929 cell lines, an MTT assay was performed. Changes in cell morphology

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Himanshi, Mukesh Kumar, and Raj Singh. "An in-vitro Evaluation of Antifungal Potential of Withania somnifera and Ageratum conyzoides weed plants against Alteneria solani." Bio Science Research Bulletin 39, no. 2 (2023): 69–74. http://dx.doi.org/10.48165/bpas.2023.39.2.4.

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The weed plants also known as ethnomedicinal plants due to their medicinal properties. These play a vital role as medicine due to their antibiotic compounds. Secondary metabolites contain structures which having activity against pathogen due to presence of phenolic, saponin, alkaloids, terpenoids and flavonoids which play a vital role to inhibit growth of pathogenic fungi. This study focused on common weeds viz. Ageratum conyzoides and Withania somnifera which found in bare area their no requirement of crop production. These exhibit antifungal, antimicrobial, anti-inflammatory, analgesic as we

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Wiciński, Michał, Anna Fajkiel-Madajczyk, Zuzanna Kurant, et al. "Ashwagandha’s Multifaceted Effects on Human Health: Impact on Vascular Endothelium, Inflammation, Lipid Metabolism, and Cardiovascular Outcomes—A Review." Nutrients 16, no. 15 (2024): 2481. http://dx.doi.org/10.3390/nu16152481.

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Withania somnifera, commonly known as Ashwagandha, has been popular for many years. Numerous studies have shown that the extract of this plant, due to its wealth of active substances, can induce anti-inflammatory, neuroprotective, immunomodulatory, hepatoprotective, cardioprotective, anti-diabetic, adaptogenic, anti-arthritic, anti-stress, and antimicrobial effects. This review examines the impact of Ashwagandha extract on the vascular endothelium, inflammation, lipid metabolism, and cardiovascular outcomes. Studies have shown that Ashwagandha extracts exhibit an anti-angiogenic effect by inhi

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Macharia, John M., Zsolt Káposztás, and Raposa L. Bence. "Medicinal Characteristics of Withania somnifera L. in Colorectal Cancer Management." Pharmaceuticals 16, no. 7 (2023): 915. http://dx.doi.org/10.3390/ph16070915.

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Research into tumorigenic pathways can aid in the development of more efficient cancer therapies and provide insight into the physiological regulatory mechanisms employed by rapidly proliferating cancer cells. Due to the severe side effects of cancer chemotherapeutic medications, plant chemicals and their analogues are now explored more frequently for the treatment and prevention of colorectal cancer (CRC), opening the stage for new phytotherapeutic strategies that are considered effective and safe substitutes. Our study aimed to evaluate the medicinal properties of Withania somnifera L. and i

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Ha, Ji Won, Jae Sik Yu, Bum Soo Lee, et al. "Structural Characterization of Withanolide Glycosides from the Roots of Withania somnifera and Their Potential Biological Activities." Plants 11, no. 6 (2022): 767. http://dx.doi.org/10.3390/plants11060767.

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Withania somnifera (Solanaceae), commonly known as “ashwagandha”, is an ayurvedic medicinal plant that has been used for promoting good health and longevity. As part of our ongoing natural product research for the discovery of bioactive phytochemicals with novel structures, we conducted a phytochemical analysis of W. somnifera root, commonly used as an herbal medicine part. The phytochemical investigation aided by liquid chromatography-mass spectrometry (LC/MS)-based analysis led to the isolation of four withanolide glycosides (1–4), including one new compound, withanoside XII (1), from the me

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Anandakumar, T. M., Devendra Kumar, B. Shivanna, and Rakesh Kumar. "Physical properties of Ashwagandha seeds (Withania somnifera L.) – A medicinal crop." Industrial Crops and Products 186 (October 2022): 115233. http://dx.doi.org/10.1016/j.indcrop.2022.115233.

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Yadav, Prerna, Ankita Lamba, Amit Meena, et al. "An Overview on Health Benefits of Withania somnifera (Ashwagandha) in Veterinary Medicine." Current Journal of Applied Science and Technology 42, no. 22 (2023): 10–16. http://dx.doi.org/10.9734/cjast/2023/v42i224166.

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Ayurvedic plants are now used more frequently in veterinary medications because they are organic and have lower toxicity and negative side effects. Withania somnifera is also known as “Ashwagandha”, and is well-known herbal plant cultivated in arid regions of India that is used in traditional medicine. Different plant components have medicinal capabilities, but the root offers the greatest number of advantages for health. Alkaloids, flavonoids, polyphenol, steroidal lactones (withanolides, withaferins), saponins containing an additional acyl group (sitoindoside VII and VIII), and withanolides

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Shivananjappa, Mahesh, K. M. Vani, R. Manasa, and D. U. Santosha. "Stress relieving activity of Withania Somnifera." IP Journal of Nutrition, Metabolism and Health Science 5, no. 4 (2022): 151–56. http://dx.doi.org/10.18231/j.ijnmhs.2022.029.

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is a valuable medicinal plant in the Solanaceae family. It is commonly known as Indian ginseng, Winter Cherry and is widely distributed around the globe. The plant is used traditional for its ameliorative properties against a human medical condition like cancer, diabetes, asthma, hypertension, stress, etc. Stress is a state of mental or emotional strain or tension, which can lead to underperformance and adverse clinical changes. is considered a potent adaptogen and anti-stress agent that could have some potential to improve physical and mental condition of a person. This review mainly focuses

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